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Category Archives: Transhuman News

Deregulation of new GMO crops: science or business? – EUobserver

Posted: October 2, 2022 at 4:42 pm

Academics and biotech research organisations with corporate interests have been leading the lobby campaign to deregulate new genomic techniques in the EU using 'climate-friendly' and 'science-based' narratives, a new report revealed on Thursday (29 September).

The findings come just a few days after the Czech EU Council presidency voiced support to loosen regulations for genetically-modified food and seed technologies in the EU.

"Advocacy is an acceptable part of democracy, but presenting stakeholders as neutral scientists is not," reads the report by the Greens in the European Parliament, which builds on Corporate Europe Observatory's (CEO) previous research.

Political pressure to change current rules for genetically-modified organisms (GMOs) has been mounting since 2018 when the European Court of Justice ruled that new techniques like CRISPR-Cas still fall under the current framework dealing with genetic-engineering products.

Current legislation imposes a pre-market authorisation on any GMO sold to consumers, following a risk assessment, as well as traceability, labelling, and monitoring obligations.

Following a request by EU member states, the commission published a study last year arguing that the current regulation is not "fit for purpose" and needs to be amended to contribute to sustainable food systems.

A legislative proposal on "plants produced by certain new genomic techniques" is due in spring 2023. What this will look like is still unclear.

But environmental groups and green MEPs fear that the upcoming commission proposal will lower standards for risk assessment and monitoring, or even forgo labelling requirements.

Industry players want to see GM plants that have no 'foreign DNA' intentionally added to their genome excluded from the EU GMO legislation. They argue that such DNA changes could also occur in nature and that gene-edited crops are key to achieving EU green goals.

The report shows how the lobby platform EU-SAGE, founded by the Flemish Biotech Institute (VIB), the European Plant Science Organisation (EPSO) working group and the European Federation of Academies of Sciences and Humanities (ALLEA) network have made similar claims.

It also notes that several academics involved in these three organisations have "strong links" with the seed industry and hold patents or patent applications in this area which are not publicly disclosed.

The debate about the deregulation of new genomic techniques has increased in recent months, due to fears over food security but the commission has acknowledged the risks of the hype.

In a briefing for a meeting between the commission's agricultural department and the lobby group Euroseed, representing companies like Syngenta and Bayer, the commission said that linking new genomic techniques to food security is "not helpful".

"This was done with GMOs in the past and ultimately the premises made were counterproductive. It is important not to promise more than what the technology can deliver," reads the briefing.

Meanwhile, many fear that the upcoming commission proposal will undermine consumers' rights.

Nina Holland, a researcher at CEO, warned that getting rid of labelling requirements would not only hinder consumers' rights but also organic farming as people will struggle to spot GMO-free products.

Green MEPs and environmentalists have urged the commission to implement the 2018 court ruling, voicing concerns over the influence that organisations with vested interests have on policy-making.

"Our decisions must be based on independent scientific advice. We cannot take scientific advice from scientists who have vested interests in the commercialisation of these products," said Green MEP Martin Husling.

Lobby groups, for their part, have slammed the 2018 court ruling for being a setback for the application of new genomic techniques which are already well-established in markets outside the EU, like the US.

"It [the ruling] created a situation in which the application of the GMO legislation would block many applications of genome-edited organisms, while at the same time the scientific community saw an enormous potential in this technology to contribute to a more sustainable agriculture and food production and help mitigate climate change," the chairman of EU-SAGE Dirk Inz told EUobserver.

Moreover, EU-SAGE and the Czech branch of ALLEA have managed to gain the support of the Czech EU Council presidency for one of their high-profile conferences on gene editing taking place in Prague on 13-14 October.

The conference, which features the logo of the EU presidency, will address "how the potential of genome-edited crops for more sustainable agriculture in Europe can be established with broader societal support".

EU agriculture commissioner Janusz Wojciechowski has been invited to take part in the programme.

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New Data Reveal Molecular Drivers of Thyroid Eye Disease (TED) May Remain Activated In Patients with Low Clinical Activity Score (CAS) – Business Wire

Posted: at 4:42 pm

DUBLIN--(BUSINESS WIRE)--Horizon Therapeutics plc (Nasdaq: HZNP) today announced the presentation of new data defining molecular patterns in TED and further implicating the role of insulin-like growth factor-1 (IGF-1) in patients with low CAS. These data were presented during the American Academy of Ophthalmology Annual Meeting (AAO 2022), Sept. 30 Oct. 3 in Chicago.

TED is a progressive and potentially vision-threatening rare autoimmune disease, which has been historically characterized as biphasic: acute, which is traditionally believed to be patients with high CAS and earlier in their TED journey; and chronic, traditionally believed to be patients with low CAS and later in the course of their disease.1 This analysis reveals that in patients with both high and low CAS, there is clear activation of IGF-1 and related pathways, as well as the extracellular matrix (ECM) organization, a structural network that supports cellular processes.2

By demonstrating that disease activity remains in patients with low CAS, this analysis may help explain why many patients who have lived with Thyroid Eye Disease for several years are still struggling with challenging symptoms that can be debilitating, said Shoaib Ugradar, M.D., The Jules Stein Eye Institute at University of California, Los Angeles (UCLA). It is important for physicians to be aware of the continued activation of IGF-1 throughout the course of the disease and its potential impact on treatment decisions.

The study analyzed genome ribonucleic acid (RNA) sequencing and pathway analysis in orbital tissue from patients with a CAS of 3 and patients with a CAS 2, as well as five control subjects. Though high CAS patients are often distinguished by activation of immune system pathways, which remain largely unaffected in low CAS patients, IGF-1 and its related pathways were found to be upregulated in both stages of disease. Additional analysis suggests that IGF-1 activity plays a central role in linking immune and ECM pathways in people with TED.2

The upregulation of IGF-1 found in low CAS patients with extended disease duration is further supported by a growing body of evidence that outlines the impact of TED on people who have lived with it for several years.3 One assessment published in the journal Ophthalmology and Therapy in 2021 found that disease burden continues well into the chronic phase, affecting daily lives with appearance and persistent visual changes, increasing risk for anxiety and depression.4

This study, which represents one of the first molecular analyses of the continuum of Thyroid Eye Disease, confirms this challenging disease may not simply subside after a few years of obvious symptoms, said Jeffrey W. Sherman, M.D., FACP, executive vice president, chief medical officer, Horizon. We are committed to pioneering research like this to better understand drivers of the evolution of this disease in order to better support patients living with Thyroid Eye Disease across the course of their lifetimes.

About Thyroid Eye Disease (TED)

TED is a serious, progressive and potentially vision-threatening rare autoimmune disease.1 TED often occurs in people living with Graves disease, but is a distinct disease that is caused by autoantibodies activating an IGF-1R-mediated signaling complex on cells within the retro-orbital space.5,6 This leads to a cascade of negative effects, which may cause long-term, irreversible damage, including blindness. Early signs and symptoms of TED may include dry eyes and grittiness; redness, swelling and excessive tearing; eyelid retraction; proptosis; pressure and/or pain behind the eyes; and diplopia.7,8

About Horizon

Horizon is a global biotechnology company focused on the discovery, development and commercialization of medicines that address critical needs for people impacted by rare, autoimmune and severe inflammatory diseases. Our pipeline is purposeful: We apply scientific expertise and courage to bring clinically meaningful therapies to patients. We believe science and compassion must work together to transform lives. For more information on how we go to incredible lengths to impact lives, visit http://www.horizontherapeutics.com and follow us on Twitter, LinkedIn, Instagram and Facebook.

References

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New Data Reveal Molecular Drivers of Thyroid Eye Disease (TED) May Remain Activated In Patients with Low Clinical Activity Score (CAS) - Business Wire

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Psoriasis Pathogenesis and Treatment – PubMed

Posted: at 4:40 pm

Review

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Adriana Rendonet al. Int J Mol Sci. 2019.

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Research on psoriasis pathogenesis has largely increased knowledge on skin biology in general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of psoriasis have been translated into targeted and highly effective therapies providing fundamental insights into the pathogenesis of chronic inflammatory diseases with a dominant IL-23/Th17 axis. This review discusses the mechanisms involved in the initiation and development of the disease, as well as the therapeutic options that have arisen from the dissection of the inflammatory psoriatic pathways. Our discussion begins by addressing the inflammatory pathways and key cell types initiating and perpetuating psoriatic inflammation. Next, we describe the role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis. Finally, we include a comprehensive review of well-established widely available therapies and novel targeted drugs.

Keywords: chronic skin disease; inflammation; psoriasis.

The authors declare no conflict of interest.

Figure 1

Clinical manifestations of psoriasis. (

Figure 1

Clinical manifestations of psoriasis. ( A , B ) Psoriasis vulgaris presents with

Clinical manifestations of psoriasis. (A,B) Psoriasis vulgaris presents with erythematous scaly plaques on the trunk and extensor surfaces of the limbs. (C) Generalized pustular psoriasis. (D) Pustular psoriasis localized to the soles of the feet. This variant typically affects the palms of the hands as well; hence, psoriasis pustulosa palmoplantaris. (E,F) Inverse psoriasis affects the folds of the skin (i.e., axillary, intergluteal, inframammary, and genital involvement).

Figure 1

Clinical manifestations of psoriasis. (

Figure 1

Clinical manifestations of psoriasis. ( A , B ) Psoriasis vulgaris presents with

Clinical manifestations of psoriasis. (A,B) Psoriasis vulgaris presents with erythematous scaly plaques on the trunk and extensor surfaces of the limbs. (C) Generalized pustular psoriasis. (D) Pustular psoriasis localized to the soles of the feet. This variant typically affects the palms of the hands as well; hence, psoriasis pustulosa palmoplantaris. (E,F) Inverse psoriasis affects the folds of the skin (i.e., axillary, intergluteal, inframammary, and genital involvement).

Erythrodermic psoriasis.

Figure 3

Onycholysis and oil drop changes

Figure 3

Onycholysis and oil drop changes on psoriatic nail involvement.

Onycholysis and oil drop changes on psoriatic nail involvement.

Figure 4

Histopathology of psoriasis. ( A

Figure 4

Histopathology of psoriasis. ( A ) Psoriasis vulgaris characteristically shows acanthosis, parakeratosis, and

Histopathology of psoriasis. (A) Psoriasis vulgaris characteristically shows acanthosis, parakeratosis, and dermal inflammatory infiltrates. (B) In pustular psoriasis, acanthotic changes are accompanied by epidermal predominantly neutrophilic infiltrates, which cause pustule formation.

Figure 5

The pathogenesis of psoriasis.

Figure 5

The pathogenesis of psoriasis.

The pathogenesis of psoriasis.

Boehncke WH, Brembilla NC. Boehncke WH, et al. Clin Rev Allergy Immunol. 2018 Dec;55(3):295-311. doi: 10.1007/s12016-017-8634-3. Clin Rev Allergy Immunol. 2018. PMID: 28780731 Review.

Schleicher SM. Schleicher SM. Clin Podiatr Med Surg. 2016 Jul;33(3):355-66. doi: 10.1016/j.cpm.2016.02.004. Epub 2016 Mar 25. Clin Podiatr Med Surg. 2016. PMID: 27215156 Review.

Ko JM, Qureshi AW. Ko JM, et al. G Ital Dermatol Venereol. 2010 Jun;145(3):393-406. G Ital Dermatol Venereol. 2010. PMID: 20461047 Review.

Blauvelt A, Chiricozzi A. Blauvelt A, et al. Clin Rev Allergy Immunol. 2018 Dec;55(3):379-390. doi: 10.1007/s12016-018-8702-3. Clin Rev Allergy Immunol. 2018. PMID: 30109481 Free PMC article. Review.

Mrowietz U, Reich K. Mrowietz U, et al. Dtsch Arztebl Int. 2009 Jan;106(1-2):11-8, quiz 19. doi: 10.3238/arztebl.2009.0011. Epub 2009 Jan 5. Dtsch Arztebl Int. 2009. PMID: 19564982 Free PMC article. Review.

Lu YW, Chen YJ, Shi N, Yang LH, Wang HM, Dong RJ, Kuang YQ, Li YY. Lu YW, et al. Front Immunol. 2022 Sep 12;13:971071. doi: 10.3389/fimmu.2022.971071. eCollection 2022. Front Immunol. 2022. PMID: 36172384 Free PMC article.

Wang Z, Zhang HM, Guo YR, Li LL. Wang Z, et al. World J Clin Cases. 2022 Jul 26;10(21):7224-7241. doi: 10.12998/wjcc.v10.i21.7224. World J Clin Cases. 2022. PMID: 36158000 Free PMC article.

Andjar I, Esplugues JV, Garca-Martnez P. Andjar I, et al. Pharmaceuticals (Basel). 2022 Sep 3;15(9):1101. doi: 10.3390/ph15091101. Pharmaceuticals (Basel). 2022. PMID: 36145322 Free PMC article. Review.

Olunoiki E, Rehner J, Bischoff M, Koshel E, Vogt T, Reichrath J, Becker SL. Olunoiki E, et al. Life (Basel). 2022 Sep 12;12(9):1420. doi: 10.3390/life12091420. Life (Basel). 2022. PMID: 36143456 Free PMC article. Review.

Nijakowski K, Gruszczyski D, Kolasiska J, Kopaa D, Surdacka A. Nijakowski K, et al. Int J Environ Res Public Health. 2022 Sep 8;19(18):11302. doi: 10.3390/ijerph191811302. Int J Environ Res Public Health. 2022. PMID: 36141573 Free PMC article. Review.

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Best and Worst Drinks for Psoriasis – Everyday Health

Posted: at 4:40 pm

It sounds plausible: If psoriasis is causing dry, scaly patches on your skin, couldnt drinking more water hydrating from the inside out improve symptoms or prevent a flare?

Dermatologists arent buying it.

Yes, psoriatic skin has hydration issues. Because the skin barrier in psoriasis is abnormal, you can lose water through the skin, saysSteven Feldman, MD, PhD, a dermatologist who specializes in psoriasis treatment at Atrium Health Wake Forest Baptist in Winston-Salem, North Carolina. Applying moisturizer to damp skin, he says, is important for hydrating psoriasis plaques.

But drinking water is a different kind of hydrating, Dr. Feldman says. There isnt any evidence that we know of that suggests drinking more water improves psoriasis.

By the way, there isnt much research to indicate that drinking extra water has any impact on skin hydration or appearance in individuals with healthy skin either, according to Mayo Clinic.

Certainly staying hydrated by drinking plenty of water is good for overall health, whether a person has psoriasis or not. Your cells, tissues, and organs need water to function properly its a key component in the regulation of body temperature and the removal of waste from the body, according to the American Academy of Family Physicians.

TheU.S. National Academies of Sciences, Engineering, and Medicine determined that women need about 11.5 cups of fluid a day and men need about 15.5 cups per day. That recommendation covers fluids obtained from water, other beverages, and food about 20 percent of daily fluid intake comes in the form of what you eat, not what you drink. If your urine is colorless or light yellow and you rarely feel thirsty, thats an indication that youre hydrating appropriately.

People with psoriasis can follow the same hydration guidelines as everyone else, says Feldman. They dont need to drink more water because of their condition, and there isnt any evidence that drinking more will improve psoriasis symptoms or prevent flares, he says.

RELATED: Hydration Calendar: How Much Water Do You Need to Drink a Day?

Topical ointments with vitamin D are sometimes used to treat psoriasis, but there isnt strong evidence to indicate that drinks fortified with vitamin D can help with psoriasis symptoms, according to theNational Psoriasis Foundation.

But people with psoriasis often have lower than normal levels of vitamin D, says the Mayo Clinic, a problem that can worsen as hours of daylight wane in the fall and winter. (Skin naturally produces vitamin D in response to sunlight.) Vitamin D is important to overall health for a host of reasons, including helping the body absorb calcium to build bone and maintaining immune function, says the National Institutes of Health.

If you do want to up your vitamin D intake through beverages, milk and orange juice fortified with vitamin D are good sources. Talk with your doctor before taking vitamin D supplements: Too much can be harmful.

Note: For people with psoriasis who are lactose intolerant or otherwise have trouble digesting dairy products, milk can be problematic because it can irritate the gut, worsening inflammation throughout the body. In some cases, people with psoriasis who cut out dairy see an improvement in their skin symptoms, according to Johns Hopkins Medicine.

Currently there isnt any evidence that antioxidants in black, green, or herbal teas will improve psoriasis symptoms, says Feldman.

Although laboratory studies suggest that antioxidants may be beneficial in lowering inflammation, the high amounts that a person would need to consume make it unlikely that antioxidants in ones diet would have any effect on psoriasis, according to a paper published in February 2021 in the journalAntioxidants.

Still, its worth remembering that people with psoriasis are at higher risk of heart disease and stroke. The antioxidants in tea can help reduce inflammation throughout the body, including the cardiovascular system, helping protect the heart and brain.

Drinking too much alcohol isnt a good idea it probably has a direct effect on psoriasis, says Feldman.

There isnt a lot of research on how drinking alcohol may impact psoriasis, but there is evidence to suggest that alcohol consumption may increase the risk of developing psoriasis and may worsen inflammation in people who already have the disease. This appears to be due at least in part to alcohols harmful effect on the gut microbiome.

Another concern is that high-calorie beverages like alcohol, juice, and sugary drinks like soda can contribute to weight gain. Evidence suggests that for people with psoriasis who are overweight or obese, treating the psoriasis and following a healthy and balanced diet that promotes weight loss could lead to fewer flare-ups and less severe disease, according to the American Academy of Dermatology.

Scientists have also linked overconsumption of sugar with chronic inflammation, which can make psoriasis worse.

Some people with psoriasis have a sensitivity to gluten, which is found in some types of alcohol, such as beer.Research suggests that for those who have the sensitivity, avoiding gluten can improve psoriasis symptoms, though it may not help much (if at all) in people without the sensitivity.

When it comes to hydration and psoriasis, you dont need to do anything special, says Feldman. Just make sure youre drinking enough water to support your overall health while limiting sweetened drinks or alcohol, he says.

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These Are the 10 Most Common Chronic Skin Conditionsand the Most Important Facts to Know About Them – Parade Magazine

Posted: at 4:40 pm

My skin is perfect, said no one ever. Real talk: By the time you hit adulthood, your skin has gone through growing pains of its own. Between the ages of 12 and 24, 85% of Americans have at least minor acne, according to the American Academy of Dermatology; another 10.7% will have eczema. Got dry skin? Youre among one in three people who deal with it every day, according to recent research.

In other words, weve all got skin issues. And just as no two people are alike, neither are the skin woes we face, meaning there is no one-treatment-fits-all plan. Each chronic skin condition has its own unique set of symptoms, causes and ways of being managed. Take a look at what the experts have to say about these 10 common skin disordersand how to keep your skin healthy now and in the future.

Leave it to the global pandemic to coin a new derm term: We seen a lot of maskne in the last two years, especially at the height of COVID, due to all the mask-wearing and how it affects the skin, saysDr. George Han, MD, PhD, an associate professor and director of research in the department of dermatology at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and Lenox Hill Hospital in New York City.

Pandemic or not, says Dr. Han, adult acne is on the rise. We have women who never had acne as kids coming in as new patients at 30 years old, he says, adding that the reason for this increase is not clear.

The condition occurs when hair follicles become clogged with oil and dead skin cells, leading to pimples, and to a lesser extent blackheads and whiteheads, according to the Mayo Clinic. Acne can occur on your face, chestand back, among other placesin the case of cystic acne, pimple-like bumps form under the skin surface.

We dont understand exactly why acne happens, however, we know that it is driven by hormones, diet and stress, saysDr. Joshua Zeichner, MD, an associate professor of dermatology and the director of cosmetic and clinical research at Mount Sinai Hospital in New York City.

Over-the-counter topical medications are the first line of defense with acne and can be effective in clearing your skin. Benzoyl peroxide is perhaps the most effective ingredient to treat angry pimples, Dr. Zeichner says. Look for formulations with 2.5% benzoyl peroxide, which studies show to be as effective as higher concentrations but with less skin irritation.

Meanwhile, topical retinoids act like pipe cleaners to keep the pores clear, Dr. Zeichner says. I use them in treating my adult acne patients because they also offer collagen-stimulating benefits to address aging skin. Products containing salicylic acid may also help, he says: This ingredient is a type of beta hydroxy acid that removes excess oil and dead cells from the surface of the skin to help dry out pimples.

If youve given these remedies a try and your acne stubbornly persists, its time to call in the reinforcements. If they are not doing the trick after one to two months, I recommend speaking to a dermatologist for professional recommendations and to consider an oral medication, says Dr. Zeichner. In adult women, we use hormonal therapies like birth control pills or spironolactone to address the hormonal impact on oil glands.

Related: Do Pimple Patches Actually Work?

If youre thinking, I didnt know dry skin was an actual condition, were with you. But theres the dish-soap-dried-out-my-hands dry skin, and then theres the clinical sort. Known as xerosis cutis, clinically dry skin can cause cracking, bleeding, itching and irritation. The condition frequently affects older people and is made worse by dry heat during winter months.

Dry skin can also be caused by another underlying condition, such as eczema or kidney disease, according to the American Academy of Dermatology (AAD). Certain medications can contribute to dry skin as well.

Treatment for dry skin starts with lifestyle changes. Follow these tips from the AAD:

In severe cases, your dermatologist might also prescribe a steroid for short-term use to calm any inflammation thats making itching or cracks in your skin worse.

Unless youve been living under a rock (pun intended), you know all about alopecia as it pertains to Jada Pinkett Smith, the Oscars and that infamous Chris Rock slap. In a nutshell, alopecia refers to hair loss. There are a few types of alopecia; alopecia areata is the most commonan autoimmune condition in which the immune system attacks hair follicles on the face, head and sometimes other areas of the body, causing hair to fall out.

Alopecia can occur in both men and women and people of any race and age, although it typically appears for the first time when people are in their 20s, 30s and 40s, per the National Institutes of Health. About 6.8 million Americans have alopecia areata, with a lifetime occurrence around 2%, according to the National Alopecia Areata Foundation.

Depending on your age, location of hair loss and extent of baldness, your doctor may talk with you about the following options to help stimulate hair growth, per the American Academy of Dermatology:

Other options include wigs, transplants or scalp prosthesis, or going the opposite route and shaving your head.

Related: Best Skincare Routine for Morning and Night

Even the word sounds itchyand with eczema, your skin usually is. We talk about eczema as the itch that rashespeople feel itchy and before their eyes, a rash starts to appear, says Dr. Han. That rash typically looks like tiny red bumps clustered together.

While the condition has no single cause, there is often a family history of asthma and allergies associated with the condition. (The condition itself is tied to genetics: If one of your parents has eczema, your risk of developing it jumps two- to three-fold, according to research in the Journal of Pediatrics.) Other triggers for the condition include smoking, stress, dry skin and hormonal fluctuations, among others.

Eczema is a condition where the skin barrier is not functioning as well as it should be, says Dr. Zeichner. In eczema, the microbiome, or collection of microorganisms that live on the skin surface, is disrupted. This leads to loss of hydration and inflammation in the skin.

Atopic dermatitis is the condition most people mean when they refer to eczemathe terms are used interchangeably. But there are several other types of the condition, according to the Cleveland Clinic, including contact dermatitis (caused by direct skin contact with an irritant); dyshidrotic eczema (blisters on hands and feet); hand eczema (symptoms are limited to your hands); neurodermatitis (patches on skin are thicker); nummular eczema (characterized by larger welts on your skin); and stasis dermatitis (caused by faulty veins that leak fluid).

The goal of treatment is to repair the skin barrier with moisturizers, says Dr. Zeichner. We also want to reduce inflammation in the skin with over-the-counter anti-inflammatories or topical or systemic medication by prescription. Treatments for eczema range from DIY therapies (warm baths, baking soda and thick moisturizers) to medical intervention. Your doctor may talk with you about calcineurin, Janus kinase and PDE4 inhibitors, or biologics, all of which work by blocking certain proteins in the body that turn on skin inflammation.

So that waseczema. The skin condition it is most commonly confused with is psoriasis. If you look at old medical textbooks, youll see that we used to distinguish between the two by saying that eczema means you have itchy skin and psoriasis doesnt itch, says Dr. Han. But in the past few decades that has been turned on its head and we now know psoriasis also itches.

In fact, he says, 80% to 90% of psoriasis patients cite itching as a primary symptom. So what makes psoriasis different than eczema? Mainly, how and where the disease appears on the body. The classic description of a psoriasis lesion is thick scaly skin on top of a plaque, says Dr. Han. It tends to be a red area thats relatively clearly cut off from the surrounding skin. Whereas with eczema, you have small red bumps in red patches on skin.

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While plaque psoriasis is the most common form of this condition, there are other types of psoriasis, including nail, scalp, guttate, inverse, pustular and erythrodermic psoriasis. In all cases, the psoriasis is caused by skin cell turnover that occurs too quickly. The process usually takes 30 days, but in people with psoriasis, cell turnover happens in three days, says Dr. Han. The dead skin cells pile up, leading to the conditions telltale plaques.

Treatments for psoriasis range from topical creams like retinoids to systemic medications, and which you use depends largely on the severity of your condition. In cases where your symptoms are very mild, you might even try home remedies for psoriasis, including moisturizers that contain salicylic acid to help exfoliate the plaques, essential oils (the benefits of these are questionable), mindfulness techniques and various foods to reduce skin inflammation. (Skip the processed foods, which make inflammation worse, according to research in the Journal of Investigative Dermatology.)

For moderate to severe psoriasis, your doctor will likely talk with you about drugs called biologics, which work by targeting the proteins in your body responsible for causing inflammation in your skin. Biologics are usually given as injections.

Related: Dermatologist-Approved Skincare Routine for Oily Skin

Rosacea can look a lot like acne but typically affects older patients as opposed to teens, says Alok Vij, M.D., a dermatologist at the Cleveland Clinic in Ohio. Rosacea can have a few components: broken blood vessels on the skin surface, pustules like acne but not blackheads and thickening of the sebaceous skin. (Picture W.C. Fields with thick skin on his nose, he suggests.)

So, how is rosacea treated? We start by classifying the severity of the disease, says Dr. Vij. If its mild, well use topical anti-inflammatory creams or antibiotics for pustular rosacea. Laser therapy may help reduce redness from blood vessels and there is some evidence that oral vitamin A therapy is helpful.

Rosacea treatment may take four weeks to see improvement because that's the length of a full skin cycle, he adds. In the meantime, many over-the-counter products and cosmetics can lessen the red appearance.

Unlike most of the common and chronic skin conditions that are marked by increased plaques, bumps or redness, the disorder vitiligo is characterized by whats missing: Namely, skin color. Vitiligo is an autoimmune condition in which your own antibodies attack cells called melanocytes in your body, says Nada Elbuluk, M.D., a clinical associate professor of dermatology at the Keck School of Medicine and director of the USC Skin of Color Center and Pigmentary Disorders Clinic at the University of Southern California in Los Angeles. These cells create melanin, which is what gives skin its color, so once they are affected, those areas of skin develop white patches.

Although scientists are still exploring the causes of vitiligo, the current thinking is that some people are genetically predisposed to the condition. There are two things that need to happen for vitiligo to occur, says Dr. Elbuluk. First, you have the genetics for it, and second, there is some sort of eventmaybe a sunburn or skin scrape or even stressthat triggers the onset of vitiligo.

The psychological impact of vitiligo can be severe: In a review of dozens of studies, a report in the American Journal of Clinical Dermatology found that 62% of people with vitiligo also suffer from depression while 68% struggle with anxiety. People with vitiligo start to self-isolate or feel uncomfortable in social situations, says Dr. Elbuluk. The emotional symptoms of the disease are very concerning.

Treatment for vitiligo varies depending on which parts and how much of the body is affected, and may include phototherapy, laser therapy, topical steroids, oral medication and surgery. Some people, though, may choose not to treat vitiligo at all. Celebrities like model Winnie Harlow have built their career celebrating their unique skin appearance.

If youve ever nicked yourself shaving, only to discover an inflamed red bump in the spot the following day, thats folliculitis. Sometimes referred to as fungal acne, the condition is marked by infected or inflamed bumps on the skin that can look like acne at first, according to the Cleveland Clinic. There are different types of folliculitis, named either for the type of bacteria that has caused the infection or the severity and location of the skin symptoms. (You can develop folliculitis anywhere and everywhere, including your butt, chestand chin.)

Folliculitis is a very common and benign condition that refers to little pimples that occur any place where there are hair follicles on your body, says Dr. Vij. You can get it on your face, thighs, back of armsjust about anywhere. Because symptoms (inflamed bumps) are typically mild, we tend to use fewer aggressive treatments, says Dr. Vij. These might include benzoyl peroxide washes and topical antibiotics, as well as warm compresses and anti-itch creams.

Related: Best Sunscreens for Sensitive Skin

Sweat much? If so, you might be among the one in 20 people in the U.S. who have hyperhidrosis, a skin condition characterized by excessive perspiration (the exact number of folks with hyperhidrosis is unknown and estimates range from one in 50 people to closer to one in 10, per the Cleveland Clinic.

We all sweat sometimesits how our body cools itself, after all. But in people with hyperhidrosis, not only is sweating excessive, it can happen at random times, for no apparent reason, when youre not even stressed. It is disruptive at best and a self-confidence crusher at its worst.

How can you tell the difference between a heavy sweater and one with a clinical disorder? The Cleveland Clinic list these symptoms of hyperhidrosis:

There are two types of hyperhidrosis: focal (also called primary) which results from a genetic mutation and generalized (also called secondary) which results from another condition or medication you may be taking.

Based on the severity of your sweating, your doctor may treat your hyperhidrosis with anything from clinical-grade antiperspirants to iontophoresisthis at-home device zaps your skin with a mild current to temporarily shut down your sweat glands, according to the American Academy of Dermatology. Other treatments include Botox injections, oral medication and even surgery to remove the sweat glands.

Hidradenitis is a condition where cysts, nodules and scars typically develop in areas like the underarms, groin and under the breasts, says Dr. Zeichner. We dont understand exactly why it happens, but we know that it is caused by blockages within sweat glands.

Risk factors for developing the condition (which can appear as bumps and blackheads on the skin surface) include family history, smoking and obesity.

Hidradenitis suppurativa is associated with other severe acne-like conditions, which are collectively known as the follicular occlusion tetrad, Dr. Zeichner says. Hidradenitis suppurativa goes through flares and remissions, but most lesions never completely clear, he adds. While medications can help keep symptoms under control, currently there is no cure.

Lifestyle modifications can help though. These include regular cleaning of the under-skin pimples with surgical-grade, antimicrobial cleansers; a healthy diet and exercise to maintain a proper body weight; and quitting smoking.

In mild cases, topical medications offer some help, says Dr. Zeichner. Cortisone injections to reduce inflammation are useful. Larger abscesses may be drained. In severe cases, plastic surgeons may remove the glands in the affected areas altogether and replace the skin with a graft.

As the disease progresses, systemic medications may be needed as well, including a biologic medication (Humira) that is FDA-approved to address the underlying inflammatory response that makes symptoms worse.

And there you have it: The main chronic skin conditions that can mess with your daily mojo. Theyre more common than most people realizeespecially when you add them all together. So if your skin is itching and you havent visited a patch of poison ivy lately, talk with your dermatologist about whats going on. If you do have one of these chronic skin disorders, treating it early will help you get back to your regularly scheduled life.

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These Are the 10 Most Common Chronic Skin Conditionsand the Most Important Facts to Know About Them - Parade Magazine

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Survey Addresses Concerns Regarding Reproductive Healthcare Communication in Women with RA, PsA – Rheumatology Network

Posted: at 4:40 pm

Holistic, collaborative, multidisciplinary, and integrated communication between physicians and women of childbearing age is lacking, according to a study published in Springer.1 Medical treatment and family planning, particularly among women of childbearing age with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), should be considered within this patient population. Patient-centered care including reproductive choices should be integrated as a part of routine clinical practice.

The proportion of women being treated with biologics is growing, investigators explained. However, data on treatment recommendation awareness among treating physicians and women who are considering pregnancy and family planning are limited.

An English-language, 55-question survey was developed to identify the current practices of physicians regarding the reproductive health needs of women with RA, PsA, and psoriasis in the Czech Republic, Slovakia, and Hungary. The questionnaire was designed to simultaneously elicit spontaneity of physicians while allowing for the processing of responses, mutual comparison, and overall assessment. The survey obtained information from 120 physicians, including 82 rheumatologists and 38 dermatologists.

Female patients of reproductive age (aged 18 to 45 years) with moderate-to-severe disease encompassed 10-30% of all respondents. Roughly two-thirds of physicians discussed family planning with their patients when making the diagnosis. Rheumatologists collaborated with other specialists more frequently when compared with dermatologists and gynecologist/obstetricians. Pregnancy effects were the top concern for female patients.

Approximately half of the rheumatologists revised treatment 6 months prior to when the patient planned on becoming pregnant (44% [n = 36/81]). However, dermatologists acted much sooner (26% [n = 10/38]), acting 2 to 3 years prior planned parenthood. While rheumatologists selected systemic glucocorticoids as firs-line treatment to counteract pregnancy flares, dermatologists preferred topical corticosteroids.

Although gender alone did not influence treatment choice in 11% of dermatologists and 39% of rheumatologists, all dermatologists and 96% of rheumatologists were influenced by the patients fertility and pregnancy. Disease severity and uncontrolled disease were the main risk factors linked to conception in this patient population. In fact, 53% of dermatologists and 79% of rheumatologists believed that poor disease control was associated with poor pregnancy outcomes. Of the most valuable sources of information as determined by physicians, congresses and interdisciplinary forums were the most highly rated. Patient education and collaboration were noted as key factors in reducing unplanned pregnancies.

A cross-border investigation, from the perspective of both rheumatologist and dermatologist, strengthened the study. However, investigators did not evaluate or categorize the individual physicians level of experience with biologics or reproductive health and instead based data on actual clinic experience. Investigators theorize that those who have had more exposure to this approach would be more willing to utilize it. The lack of formal survey validation, and the fact that the survey was provided in English, further limits the study.

To improve the reproductive health of sexually active women of childbearing age in Central Europe who have chronic inflammatory diseases (CID), rheumatologists and dermatologists must improve their education and work with other specialists, investigators concluded. More timely discussions with women of reproductive age and family planning are needed to educate them about the disease's effects on their childbearing potential and the selection of treatment options based on their reproductive goals. Best practices in patient-centered care must consider each patient's reproductive decisions in their treatment planning to give the best patient-centered care.

Reference:

Olejrov M, Macejov , Gkalpakiotis S, Prochzkov L, Tth Z, Prgr P. Reproductive Healthcare in Women with Rheumatoid Arthritis and Psoriatic Diseases in Routine Clinical Practice: Survey Results of Rheumatologists and Dermatologists [published online ahead of print, 2022 Sep 24]. Rheumatol Ther. 2022;10.1007/s40744-022-00488-z. doi:10.1007/s40744-022-00488-z

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Soma (drink) – Wikipedia

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Vedic ritual drink

In the Vedic tradition, sma (Devanagari: ) is a ritual drink[1][2] of importance among the early Vedic Indo-Aryans.[3] The Rigveda mentions it, particularly in the Soma Mandala. Gita mentions the drink in Chapter 9.[4] It is equivalent to the Iranian haoma.[5][6]

The texts describe the preparation of soma by means of extracting the juice from a plant, the identity of which is now unknown and debated among scholars. Both in the ancient religions of Historical Vedic religion and Zoroastrianism, the name of the drink and the plant are not exactly the same.[7]

There has been much speculation about the most likely identity of the original plant. Traditional Indian accounts, such as those from practitioners of Ayurveda, Siddha medicine, and Somayajna called Somayajis, identify the plant as "Somalata" (Sarcostemma acidum).[8]Non-Indian researchers have proposed candidates including the fly agaric, Amanita muscaria; Psilocybin mushrooms, Psilocybe cubensis; wild or Syrian rue, Peganum harmala; and ma huang, Ephedra sinica.

Soma is a Vedic Sanskrit word that literally means "distill, extract, sprinkle", often connected in the context of rituals.[9]

Soma's Avestan cognate is the haoma. According to Geldner (1951), the word is derived from Indo-Iranian roots *sav- (Sanskrit sav-/su) "to press", i.e. *sau-ma- is the drink prepared by pressing the stalks of a plant,[10] but the word and the related practices were borrowed by the Indo-Aryans from the BactriaMargiana culture (BMAC). Although the word is only attested in Indo-Iranian traditions, Manfred Mayrhofer has proposed a Proto-Indo-European origin from the root *sew(h)-.[13]

The Vedic religion was the religion of some of the Vedic Indo-Aryan tribes, the aryas, who migrated into the Indus River valley region of the Indian subcontinent. The Indo-Aryans were speakers of a branch of the Indo-European language family, which originated in the Sintashta culture and further developed into the Andronovo culture, which in turn developed out of the Kurgan culture of the Central Asian steppes. The Vedic beliefs and practices of the pre-classical era were closely related to the hypothesised Proto-Indo-European religion,[18][note 1] and show relations with rituals from the Andronovo culture, from which the Indo-Aryan people descended. According to Anthony, the Old Indic religion probably emerged among Indo-European immigrants in the contact zone between the Zeravshan River (present-day Uzbekistan) and (present-day) Iran. It was "a syncretic mixture of old Central Asian and new Indo-European elements" which borrowed "distinctive religious beliefs and practices" from the BactriaMargiana culture (BMAC). This syncretic influence is supported by at least 383non-Indo-European words that were borrowed from this culture, including the god Indra and the ritual drink Soma. According to Anthony,

Many of the qualities of Indo-Iranian god of might/victory, Verethraghna, were transferred to the adopted god Indra, who became the central deity of the developing Old Indic culture. Indra was the subject of 250hymns, a quarter of the Rig Veda. He was associated more than any other deity with Soma, a stimulant drug (perhaps derived from Ephedra) probably borrowed from the BMAC religion. His rise to prominence was a peculiar trait of the Old Indic speakers.

In the Vedas, the same word (soma) is used for the drink, the plant, and its deity. Drinking soma produces immortality (Amrita, Rigveda 8.48.3). Indra and Agni are portrayed as consuming soma in copious quantities. In the vedic ideology, Indra drank large amounts of soma while fighting the serpent demon Vritra. The consumption of soma by human beings is well attested in Vedic ritual. The Soma Mandala of the Rigveda is completely dedicated to Soma Pavamana, and is focused on a moment in the ritual when the soma is pressed, strained, mixed with water and milk, and poured into containers. These actions are described as a representation of a variety of things, including a king conquering territory, the Sun's journey through the cosmos, or a bull running to mate with cows (represented by the milk). The most important myth about Soma is about his theft. In it, Soma was originally held captive in a citadel in heaven by the archer Knu. A falcon stole Soma, successfully escaping Knu, and delivered Soma to Manu, the first sacrificer. Additionally, Soma is associated with the moon in the late Rigveda and Middle Vedic period. Sry, the daughter of the Sun, is sometimes stated to be the wife of Soma.[22]

The Rigveda (8.48.3) says:

pma smam amt abhmaganma jytir vidma devnk nnm asmn kravad rtikm u dhrtr amrta mrtiyasya[23]

Stephanie W. Jamison and Joel P. Brereton translates this as:

We have drunk the soma; we have become immortal; we have gone to the light; we have found the gods.What can hostility do to us now, and what the malice of a mortal, o immortal one?[24]

Swami Dayanand Saraswati explains this as:

Good fruit containing food not any intoxicating drink, we drink youYou are elixir of life, achieve physical strength or light of god,achieve control over senses;In this situation, what our enemy can do to me?God, what even violent people can do to me?

Also, consider Rigveda (8.79.2-6)[25] regarding the power of Soma:"...He covers the naked and heals all who are sick. The blind man sees; the lame man steps forth....Let those who seek find what they seek: let them receive the treasure....Let him find what was lost before; let him push forward the man of truth...."Such is indicative of an experience with an entheogen of some source...(Michael Wood (historian)).(The Story of India)

The finishing of haoma in Zoroastrianism may be glimpsed from the Avesta (particularly in the Hm Yast, Yasna 9), and Avestan language *hauma also survived as Middle Persian hm. The plant haoma yielded the essential ingredient for the ritual drink, parahaoma.

In Yasna 9.22, haoma grants "speed and strength to warriors, excellent and righteous sons to those giving birth, spiritual power and knowledge to those who apply themselves to the study of the nasks". As the religion's chief cult divinity he came to be perceived as its divine priest. In Yasna 9.26, Ahura Mazda is said to have invested him with the sacred girdle, and in Yasna 10.89, to have installed haoma as the "swiftly sacrificing zaotar" (Sanskrit hotar) for himself and the Amesha Spenta.

Soma has been mentioned in Chapter 9, verse 20 of Bhagavad Gita:

Those who perform actions (as described in the three Vedas), desiring fruit from these actions, and those who drink the juice of the pure Soma plant, are cleansed and purified of their past sins.Those who desire heaven, (the Abode of the Lord known as Indralok) [26] attain heaven and enjoy its divine pleasures by worshipping me through the offering of sacrifices.Thus, by performing good action (Karma, as outlined by the three Vedas, one will always undoubtedly receive a place in heaven where they will enjoy all of the divine pleasure that are enjoyed by the Deities.[citation needed][note 2]

The Maharishi Mahesh Yogi's Transcendental Meditation-Sidhi Program involves a notion of "soma", said to be based on the Rigveda.[27][28]

There has been much speculation as to the original Sauma plant. Candidates that have been suggested include honey, mushrooms, psychoactive and other herbal plants.[29]

When the ritual of somayajna is held today in South India by the traditional Srautas called Somayajis, the plant used is the somalatha (Sanskrit: soma creeper, Sarcostemma acidum)[8] which is procured as a leafless vine.

Since the late 18th century, when Abraham Hyacinthe Anquetil-Duperron and others made portions of the Avesta available to western scholars, several scholars have sought a representative botanical equivalent of the haoma as described in the texts and as used in living Zoroastrian practice. In the late 19th century, the highly conservative Zoroastrians of Yazd (Iran) were found to use ephedra, which was locally known as hum or homa and which they exported to the Indian Zoroastrians.[30]

During the colonial British era scholarship, cannabis was proposed as the soma candidate by Jogesh Chandra Ray, The Soma Plant (1939)[31] and by B. L. Mukherjee (1921).[32]

In the late 1960s, several studies attempted to establish soma as a psychoactive substance. A number of proposals were made, including one in 1968 by the American banker R. Gordon Wasson, an amateur ethnomycologist, who asserted that soma was an inebriant but not cannabis, and suggested fly-agaric mushroom, Amanita muscaria, as the likely candidate. Since its introduction in 1968, this theory has gained both detractors and followers in the anthropological literature.[33][34][35] Wasson and his co-author, Wendy Doniger O'Flaherty, drew parallels between Vedic descriptions and reports of Siberian uses of the fly-agaric in shamanic ritual.[36]

In 1989 Harry Falk noted that, in the texts, both haoma and soma were said to enhance alertness and awareness, did not coincide with the consciousness altering effects of an entheogen, and that "there is nothing shamanistic or visionary either in early Vedic or in Old Iranian texts", (Falk, 1989) Falk also asserted that the three varieties of ephedra that yield ephedrine (Ephedra gerardiana, E. major procera and E. intermedia) also have the properties attributed to haoma by the texts of the Avesta. (Falk, 1989) At the conclusion of the 1999 Haoma-Soma workshop in Leiden, Jan E. M. Houben writes: "despite strong attempts to do away with ephedra by those who are eager to see sauma as a hallucinogen, its status as a serious candidate for the Rigvedic Soma and Avestan Haoma still stands" (Houben, 2003).

The Soviet archeologist Viktor Sarianidi wrote that he had discovered vessels and mortars used to prepare soma in Zoroastrian temples in the BactriaMargiana Archaeological Complex. He said that the vessels have revealed residues and seed impressions left behind during the preparation of soma. This has not been sustained by subsequent investigations.[37] Alternatively Mark Merlin, who revisited the subject of the identity of soma more than thirty years after originally writing about it[38] stated that there is a need of further study on links between soma and Papaver somniferum. (Merlin, 2008).[39]

In his book Food of the Gods, ethnobotanist Terence McKenna postulates that the most likely candidate for soma is the mushroom Psilocybe cubensis, a hallucinogenic mushroom that grows in cow dung in certain climates. McKenna cites both Wasson's and his own unsuccessful attempts using Amanita muscaria to reach a psychedelic state as evidence that it could not have inspired the worship and praise of soma. McKenna further points out that the 9th mandala of the Rig Veda makes extensive references to the cow as the embodiment of soma.[citation needed]

According to Michael Wood, the references to immortality and light are characteristics of an entheogenic experience.[40]

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Lavish Qin Shi Huang Tomb Built for Immortality

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A lust for everlasting life resulted in the massive Qin Shi Huang tomb.

At just thirteen years old, the boy-king, Ying Zheng (259 BCE 210 BCE), began to construct his own tomb in todays Lintong District, Xian, in Chinas Shaanxi province. At the age of 38, King Zheng would unite all the warring states and become the first Emperor of China, Qin Shi Huang. As the emperors power and wealth grew, so too did his obsession with his afterlife. He designed and constructed a mausoleum larger and more extravagant than the world had ever seen before. The Qin Shi Huang tomb and his surrounding 38 square mile necropolis would contain every single detail of the emperors luxurious life on earth, including a terracotta army to protect him all of which he would take into the afterworld.

In 260 BCE, China was in a state of turmoil. Various feudal states divided the country, and the Warring States Period had lasted for 250 years. Seven individual kingdoms tried to establish their dominance and lay claim to the entire country. However, the strongest of these states was Qin. When King Zhuangxiang began his reign in September of 250 BCE, it appeared that he would become Chinas first emperor. However, his reign was short-lived. After just three years in power, he died.

King Zhuangxiangs heir was his young son named Ying Zheng. A regent served as temporary ruler until the young king was old enough to rule on his own. Ying Zheng exhibited traits from the very beginning that marked him as calculating and fearless. At the age of 21, he led a revolt against his regent who tried to maintain control. This culminated in bloodshed and removed every obstacle to the kings reign.

Despite multiple assassination attempts, the King of Qin managed one successful campaign after another until he defeated all rival states throughout the land. In 221 BCE, the warrior king accomplished something no other leader had. He united the kingdom and created the first Chinese empire. Although he was a harsh despotic ruler, he left behind important legacies: the Great Wall, a vast network of roads that connected his empire, and one system of weights, measures, money, and writing.

As he approached his 40th year, the king proclaimedhimself Qin Shi Huangdi, a name that conveyed his power as the first high-god (or godlike emperor) of Qin. According to Chinese belief, Zhengs successes conferred upon him the mandate of heaven. As the Son of Heaven he would rule from the center of the universe like a god. From this point, the emperor became obsessed with maintaining his divine power (and possessions) even in the afterlife.

The digging and preparation of Ying Zhengs tomb had begun immediately upon his coronation as king around 246 BCE. As the king grew into a man and later became Emperor, he would amass more power and control than anyone had ever seen in the kingdom. Likewise, he acquired wealth and luxury beyond imagination. The power-hungry emperor wanted to take everything and everyone he needed to his next life. Thus, his engineering designs for his mausoleum became much more grandiose. However, he desperately feared death and hoped that he would never need his to use his mausoleum.

Qin Shi Huang embarked upon a mad search for the elixir of life. The legend about the Mountain of Immortality led him to travel three times to the island of Zhifu. He also built secret tunnels beneath his 200 palaces so that he could travel safely unseen, and he forced scholars, alchemists, and magicians to focus all of their attention on finding a cure for mortality.

In a bitter twist of irony, Qin Shi Huang died from drinking the mercury that he believed would make him immortal. Ultimately,he could not cheat death and would need his mausoleum after all. Slave laborers had worked day and night for three decades and would not complete the necropolis until 208 BCE, almost two years after the emperors death at age 49 in 210 BCE.

Designers intentionally built the mausoleum to resemble the capital of Qin, Xianyang. It includes both an inner and outer city, divided by two distinct walls. Archaeologists believe that Qin Shi Huangs tomb lies in the southwest of the inner city under the mound where it faces east.

Sima Qian claimed that 700,000 men, including slaves, built the emperors mausoleum. Some historians have pointed out that no city from that period of history had such a population. Hence, they speculate that sixteen to twenty thousand laborers may be a more accurate assessment. Regardless of the number, it is certain that those peasants and slaves met a tragic end. Archaeologists found mass burial pits around the mausoleum site piled high with the bones of builders. Some of them were still wearing metal shackles.

Additionally, scholars theorize, based on clues left by Sima Qian, that the craftsmen who had worked on mechanical devices designed to prevent entry into the burial chamber were put to death. They had observed the treasures in the Qin Shi Huang tomb and could not be trusted with those secrets. Once they placed the emperor deep inside the tomb, another group sealed off the passage, probably leaving behind anyone who knew the location of the emperor.

Forty years of archaeological studies of the mausoleum site have revealed that Qin Shi Huang intended to design his afterlife to match his life on earth in every respect. This included his imperial court life and the external environment that surrounded his city.

Near the outer wall of the greater mausoleum complex, a discovery of a royal park included bronze swans, ducks, and cranes, along with an entire suite of musicians. A horse stable discovered outside the outer walls contained horse skeletons and their terracotta caretakers. Altogether, there were roughly 300 coffins containing horse skeletons. Inside the inner wall, another pit contained the emperors terracotta attendants and government officials.

Additionally, in 1980 two chariots were discovered in passageways that appear to lead to the innermost walls of the Qin Shi Huang tomb under the burial mound. Each chariot was attached to four bronze horses. According to the Han Dynasty scholar Cai Yong ( 132-192), the first chariot was for clearing the road for the Emperors entourage, and the second was his sleeping chariot. The bridles and saddles of the horses are inlaid with gold and silver designs and the body of the number 2 chariot has its sliding windows hollow cut (Exploring Chinese History).

Close to the mound of the Qin Shi Huang tomb, scientists also found a mysterious pit of partially unclothed statues. Recent examination indicates that theywere an entire imperial court of musicians, acrobats, and weightlifters designed to ensure the first emperor would have entertainment in his next life.

In addition to the imperial court, archaeologists found pits within the mausoleum complex containing the skeletal remains of young females. The scientists believe they were the emperors concubines. Evidence suggests foul play, as dismembered body parts lay strewn about along with some scattered pearls and gold jewelry. These were not proper burials. According to Sima Qian, the usurper of the emperors successor ordered the death of the concubines. In theory, this would have prevented any unborn challenges to the throne.

In 2012 archaeologists announced the largest underground complex discovered so far within the Qin Shi Huang tomb necropolis. It is an entire courtyard palace and is roughly 170,000 square meters. This equals about 42 acres. The palace grounds contain one main building that overlooks 18 other royal houses, walls, roads, brickwork, and pottery shards.

About a mile east of the tomb, a hallmarkdiscovery occurred when local villagers of the Lintong county embarked upon digging a well in March of 1974. Approximately six feet below ground, the villagers unearthed terracotta fragments and bricks.

Soon after the discovery, archaeologists began excavations. To date, they have identified three separate pits that contain about 8,099 terracotta statues of warriors, weapons, and horses with their chariots. Many of the statues were badly damaged, and scientists reconstructed only about 2000 of them so far. Experts estimate that it may take another 50 years to complete the excavation project.

Presumably, the purpose of the Terracotta Army was to protect the emperor from his enemies in the afterlife. Interestingly, the pits are located between the emperors tomb and what was enemy territory. Additionally, the soldiers stand in battle formation facing east toward the kingdoms he conquered.

The pits contain infantrymen, cavalry, and high-ranking officers, in addition to their horses and weapons. Each statue reveals exquisite details in hair and battle regalia, and each face holds different expressions and features. Some experts believe that the sculptors of the Terracotta Army designed them as exact likenesses to the best warriors that existed in Emperor Qins real army.

Nothing of the likes of the Terracotta Army has ever existed in China before. It is uncertain who crafted the statues, however, scholars theorize that Hellenistic Greek sculptors may have taught the artists under Emperor Qin. Today, the statues still stand in their original corridors, and the whole site has been enclosed in a museum where visitors can see the army.

You May Also Like: Terracotta Army: Eternal Sentinels of Qin Shi Huang

At the center of the enormous necropolis lies a pyramid mound that was once 350 feet high. Workers constructed the mound by packing dirt into the shape of a pyramid, shown below. Archaeologists believe there is an underground palace below the mound surrounded by walls that are about 4 meters high. The Qin Shi Huang tomb lies at the center of the mound, indicated with the brightwhite spot. However, experts are uncertain exactly how deep the tomb chamber is. Estimates place it between 20-50 meters below the surface.The chamber itself is still undisturbed.

Historical Recordsby Sima Qian is the first written documentation about the first emperors tomb:

[blockquote align=none author=Sima Qian]The site includes three streams, and his coffin is encased in a bronze sarcophagus. The floor of the central burial chamber floats on rivers, lakes, and seas of mercuryThe vaulted ceiling is inlaid with pearls and gems to emulate the sun, moon, and principal stars of the constellations in the night sky. Whale oil lamps are brightly lit for an everlasting effect of illustriousness.[/blockquote]

Using modern scientific techniques, scientists have revealed details that may confirm the historical record of Sima Qian. As noted, Qian wrote that designers of the tomb used mercury to create simulations of rivers and seas in the tomb. Archaeologists have detected extremely high levels of mercury in the area. Additionally, imaging and other tests revealed the presence of a vast amount of metal within. This also affirms Qians account that the emperor took his treasures with him.

There is an ongoing debate in China that has delayed the complete excavation of the Qin Shi Huang tomb. Some people maintain that an excavation is immediately necessary due to the potential for seismic activity in the region. However, others argue that China does not yet possess the technology or ability to carry out the exploration properly. There is also trepidation, as stories tell of entryways that have booby traps to prevent access to the tomb, and high levels of mercury could pose a health risk.

With over 600 archaeological sites, including the stunning Terracotta Army, the Qin Mausoleum is a magnificent historical treasure. The ancient artifacts can tell us about the sculpture, engineering, rituals, entertainment, military personnel, rank, and strategy, and the deeply held beliefs of the people who lived more than 2000 years ago. In 1987, UNESCO declared the Qin Shi Huang mausoleum and the Terracotta Soldiers a World Heritage Site due to their immeasurable testament to the rich history of China.

You May Also Like: Secret Tomb of Genghis Khan

Additional references:BBC

Updated by Historic Mysteries on January 18, 2018

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Lavish Qin Shi Huang Tomb Built for Immortality

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The Four Directions & Medicine Wheel of Native Americans – Gaia

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Crocodile came to me recently in ceremony. At first I was startled by his appearance, feeling I have already embraced every shadow aspect of myself he represents. Since his visit, however, I have spent time welcoming him and examining the teachings he now brings.

Crocodile/Snake holds our basal self, our deepest fears and lesser-evolved leanings which are held in the reptilian brain. In sacred ceremony and spiritual initiations, it is snake or crocodile who confronts you to face and embrace that which you fear most. His personal challenge to me: Youre not a true shaman. You dont work in the rain forest, you dont ingest plant medicines, and youre falsely holding your craft, thereby misleading those you serve.

On more than one occasion I have been questioned and warned against calling myself a shaman. I havent studied in the jungle, I dont have any hint of bronzed pigment in my Irish skin, and I dont have a Maestro or don teaching me the ways. My path is unique in devoted past-life reclamation, shamanic journey, and an early proclamation at five-years-old that I would be a shaman. I was born ready and havent looked back. However, the thorny challenges still arise.

Enter the internal struggle of spirit and shadow. Its brought me to a place of deep self-inquiry and an eventual and potent reclamation. Its also offered me a new perspective on the path of the modern shaman.

When asked, What is a shaman? my easiest answer is someone who works in the invisible spaces to bring peace and healing to those whom they are in service.

Shamans are intermediaries or messengers between the human world and the spirit worlds. Shamans are said to treat ailments/illness by mending the soul. Alleviating traumas affecting the soul/spirit restores the physical body of the individual to balance and wholeness. The shaman also enters supernatural realms or dimensions to obtain solutions to problems afflicting the community. Shamans may visit other worlds/dimensions to bring guidance to misguided souls and to ameliorate illnesses of the human soul caused by foreign elements. The shaman operates primarily within the spiritual world, which in turn affects the human world. The restoration of balance results in the elimination of the ailment.

Tryptamine Palace

In Cave and Cosmos, Michael Harner suggests it is simply one who knows.

The big divide in the shamanic communities lies between those who work in the rain forest with the lineage of indigenous wisdom in their blood; and so-called Plastic Shamans who have no connection to the cultures and traditions they represent.

As shamanism has gained prevalence in the modern era, core shamanism has become the accepted term for those who use the methods of the shaman but have not been raised in the traditional cultures. The Foundation for Shamanic Studies has reintroduced the shamanic journey for self-healing, while the Psychonauts have lead a revolution through chemically assisted self-inquiry. Both are valid paths that differ greatly from a jungle education. While the efficacy of the practice is all that should matter, there still lies a division.

Another crucial distinction for indigenous shamans is their relationships with the plants. Dietas are ceremonial ingestions of plant medicines that teach the shaman how to walk between and within the astral worlds. Any number of teacher plants are used, from tobacco to ayahuasca. These ceremonies are performed with great reverence and honor and remain within sacred guidelines as sincere spiritual endeavors to deepen the path of the seeker. The illusion of this world fades away and great insights are gained, revealing the true nature of ones own soul.

Freakin awesome when done in this sacred space, right?

I, however, am a different kind of shaman. I traverse the dimensions without the use of hallucinogens. Drums, deep meditation, and the psychic connection with spirits and plant allies, for me, have been enough. And Croc challenged me on this also: Is your plant abstinence genuinely enough to gain such an alliance with the spirit realms?

In the modern world, our relationship to the plants is vastly different than that of the indigenous shaman. We dont commune with them personally, nor do we seek to hone their wisdom. As a result, contemporary seekers often misuse the medicines. In my younger days, I experimented with mushrooms recreationally. I found them an expansive and uplifting dalliance that only affirmed my path as a seer and healer. Yet I took them with no noble intent.

Recently, I found myself called to work more closely with the plants in ceremonial space and felt conflicted. My ego holds my hallucinogenic refrain as a badge of honor a way of ensuring the purity of the messages received. And yet I found myself deeply appreciating the plant spirits again, in great awe and gratitude for the teachings they shared.

And what they shared was this: Ive connected more than sufficiently with the plant spirits. I learn and walk beside them every day to offer blessings to my community. I need not ingest them, for they have been my allies all along!

In a recent Aubrey Marcus podcast, Astral Snakes and Binaural Beats (episode 59), Cory Allen shared his most recent devotion is not in using the plant medicines, but rather simply being in the astral plane without any enhancements. Under the influence of the medicine, The consciousness of the plant is with you in that space and colors your vision of that space. If you get there without it, you are completely you and you are on your own. Boom, validation! And Croc began to smile.

What I realized was, it all comes back to me not having any allies, any perceptions, any filters on my experience in these worlds. The mark of the shaman is not who they are when theyre on the medicines or how they handle these energies inside of them. It is who they are in the absence of any aids at all!

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The Four Directions & Medicine Wheel of Native Americans - Gaia

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Kanye, Selena Gomez have bipolar disorder. Why is there a stigma? – USA TODAY

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Kim Kardashian comments on husband Kanye West's bipolar disorder

Kim Kardashian calls for "compassion and empathy" after husband Kanye Wast's recent comments, stating he struggles with bipolar disorder.

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Like many people,Joscelyn Guzmanknew what it was like to be depressed. For much of her life, she had been shown compassion and empathy whenever she spoke about her struggles with depression that is, until, she experienced a bipolar manic episode.

For onemonth, Guzman was riddled withuncontrollable euphoria. She channeled herenergy into impulsive hobbies and could notsleep or eat for days. If she wanted a T-shirt, she wound up spendinghundreds of dollars on a shopping spree.If she wanted to make a YouTube video, she'd record hours of footagein the middle of the night.

Inone of the worstmoments of her manic episode, Guzman convincedherself that her confidencewas super-human.That her lack of sleep or foodmade her immortal.

She believed she wasGod.

"I haven't shared this very much," says Guzman, 26."People would probably look down on me for saying that, but in my mind, I really couldn't control it."

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But one day, herhighwasreplaced with a newfound wave of paranoia,depressionand suicidal thoughts a lowthat wasso sudden andoverwhelming, it prompted a hospital visit.And shortly after, Guzman was officially diagnosed with bipolar disorder.More specifically, bipolar I, whichcauses manicepisodes that last at least 7 days and depressive episodes that last at least two weeks, according to theNational Institute of Mental Health.

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It's a complex and misunderstood diagnosisthat, despite growing awareness, is still stigmatized.

The pandemic accelerated a positive movement towardmental health prioritization, but experts and those who have dealt with more severe mental health issues,like mania, say the empathy and understanding doesn't always extend to conditions like bipolar disorder.

"I think everybody who reads this story will have mental health problems," says Patrick Corrigan, aprofessor of psychology at Illinois Institute of Technology. "Everyone knows what it means to be depressed or (have) anxiety, but the fundamental thing about stigma is difference. While one may get depressed occasionallyor a bit euphoric once in a while, most people don't know what it's like to be in the throes of a manic episode."

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Like depression, bipolar disorder is a mood disorder characterized by shifts inenergy, activity levels and concentration.The difference, however, is those with bipolar disorder experience alternating periods of depression and mania.

A manic episode typically lasts from a few weeks to a few months, accordingto Kay Redfield Jamison, a professor of psychiatry at theJohn Hopkins School of Medicine. Common signs can include "extreme irritability and paranoia, grandiosity and euphoria, changing in thinking (and) speaking a lot, very rapidly."

"People get highly sociable and disruptive. People sleep much less, are much more activated in general. It's a very high-energy state."Jamison, who specializes in mood disorders, also has firsthand experience with bipolar disorder, writing about it inher book, "An Unquiet Mind: A Memoir of Moods and Madness."

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In some cases, manic episodes can also include elements of psychosis,such as delusions, which Corriganexplainsare false, grandiose beliefs ("like 'I'm a man on the moon'") as well asvisual or auditory hallucinations.

At first, no one helped Guzman during her month-long manic episode. It wasn't because they didn't care. It's because they didn't know.

On the outside, her energy seemed uncharacteristicbut not eyebrow-raising.Friends and familydidn't recognize that she was plagued by powerful delusions while getting little-to-no sleep each night.

But this nuance,experts warn, is part of the complexity of bipolar disorder.

Often times, the media depicts mania (or even "maniacs") in an extremeway. Characters experiencing psychosis, like DC Comic's Harley Quinn, are oftenstereotyped with"crazy behavior. Hearing things, seeing things, talking to yourself and making no sense," Corrigan says.

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The realityis thatmania can manifest in subtle and positive ways at first, making it harder to spot.Singer Bebe Rexha said, in a tweet announcing her diagnosis,the "highs" initially contributed to her strong work ethic.And Kanye West, who has rapped about hisbipolar disorder,is often glamorizedby some fans.

"Sometimes, the maniaseemspositive, but I know it can get really dark. That's why it's important we don't make it seem like this amazing thing, because it's not: It's your mind not being OK, and the real-life consequence is death," Guzman says.

Jamison adds, "It is a very interesting illness and certainly associated with creativity, which runs the risk of romanticizing a very potentially lethal illness." The rate of suicide among people who deal with bipolar disorderis approximately 10 to 30 times higher than the general population, research has shown, with2060% of them attemptingsuicide at least once in their lifetime.

In recent years, more people have been spreading awareness about the importance of de-stigmatizing bipolar disorder including celebrities.

In 2018, Mariah Careyrevealed her bipolar diagnosis, encouraging others to seek treatment after "the hardest couple of years I've been through." Selena Gomezhas shared her personalexperiences in an effort to rid the shame often associated with it, andWest has challengedthe "crazy" label that is often slapped onto mental illness.EvenHalsey, also diagnosed with bipolar disorder, responded to the lack of compassion towardWest duringhis public mental health struggle.

"Im so disturbed by what Im seeing," Halsey tweeted. "A manic episode isn't a joke. If you cant offer understanding or sympathy, offer your silence."

Selena Gomez: explains why mental health is 'personal' at White House, MTV event

Open, judgement-free conversations about mental health that gobeyond sadness and anxietyare the first step to de-stigmatization and compassion.

"Know about mania. Know about your illness. Know about the treatments for it. Always ask questions," says Jamison.

Beyond awareness, however, Corrigan emphasizes the importance of learning about these diagnoses by listening topeople's real-life experiences.It'swhat inspiredGuzman to shareher story with us.

"There's so much stigma around mental illness in general and then especially bipolar disorder," she says. "But I'm going to keep talking about being diagnosed bipolar. I'm going to talk about being in therapy. I'm going to talk about mental illness."

If you or someone you know is experiencing a mental health crisis,call the988 Suicide and Crisis Lifelinewhich provides confidential 24/7 support by dialing 9-8-8.

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Kanye, Selena Gomez have bipolar disorder. Why is there a stigma? - USA TODAY

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