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DNA, persistence reveal family shocker – Fort Wayne Journal Gazette

Posted: August 6, 2017 at 2:46 am

Five years ago, Alice Collins Plebuch made a decision that would alter her future or really, her past.

She sent away for a just-for-fun DNA test. When the tube arrived, she spit and spit until she filled it up to the line, and then sent it off in the mail. She wanted to know what she was made of.

Plebuch, now 69, already had a rough idea of what she would find. Her parents, both deceased, were Irish-American Catholics who raised her and her six siblings with church Sundays and ethnic pride. But Plebuch, who had a long-standing interest in science and DNA, wanted to know more about her dad's side of the family. The son of Irish immigrants, Jim Collins had been raised in an orphanage from a young age, and his extended family tree was murky.

After a few weeks during which her saliva was analyzed, she got an email in the summer of 2012 with a link to her results. The report was confounding.

About half of Plebuch's DNA results presented the mixed British Isles bloodline she expected. The other half picked up an unexpected combination of European Jewish, Middle Eastern and Eastern European. Surely someone in the lab had messed up. It was the early days of direct-to-consumer DNA testing, and Ancestry.com's test was new. She wrote the company a nasty letter informing them they'd made a mistake.

But she talked to her sister, and they agreed she should test again. If the information Plebuch was seeing on her computer screen was correct, it posed a fundamental mystery about her very identity.

Popular practice

Over the past five years, as the price of DNA testing kits has dropped and their quality has improved, the phenomenon of recreational genomics has taken off. According to the International Society of Genetic Genealogy, nearly 8 million people worldwide, but mostly in the United States, have tested their DNA through kits, typically costing $99 or less, from such companies as 23andMe, Ancestry.com and Family Tree DNA.

The most popular DNA-deciphering approach, autosomal DNA testing, looks at genetic material inherited from both parents and can be used to connect customers to others in a database who share that material. The results can let you see exactly what stuff you're made from as well as offer the opportunity to find previously unknown relatives.

But DNA testing can also yield surprises.

We see it every day, says CeCe Moore, a genetic genealogist and consultant for the PBS series Finding Your Roots. She runs a 54,000-person Facebook group, DNA Detectives, that helps people unravel their genetic ancestries. You find out that a lot of things are not as they seem, and a lot of families are much more complex than you assume.

Testing others

After the initial shock of her test results, Plebuch wondered whether her mother might have had an affair. Or her grandmother, perhaps? So, she and her sister, Gerry Collins Wiggins, both ordered kits from DNA testing company 23andMe.

As they waited for their results, they wondered. If the Ancestry.com findings were right, it meant one of Plebuch's parents was at least partly Jewish. But which one?

She plunged into online genealogy forums, researching how other people had traced their DNA and educating herself about the science. She and her sister came up with a plan: They would persuade two of their first cousins to get tested their mother's nephew and their father's nephew. If one of those cousins was partly Jewish, they'd know for sure which side of the family was contributing the mysterious heritage. The men agreed. The sisters sent their kits and waited.

Then Plebuch's own 23andMe results came back. They seemed consistent with her earlier Ancestry.com test. She also discovered that her brother Bill had recently taken a 23andMe test. His results were a relief sort of.

No hanky-panky, as Plebuch puts it. They were full siblings, sharing about 50 percent of the relevant DNA, including the same mysterious Jewish ancestry.

Plebuch found a feature on 23andMe's website showing what segments along her chromosomes were associated with Ashkenazi Jews. Comparing her DNA to her brother's, she had a sudden insight. There was a key difference between the images, lurking in the sex chromosomes. Along the X chromosome were blue segments indicating where she had Jewish ancestry, which could theoretically have come from either parent because females inherit one X from each. But males inherit only one X, from their mothers, along with a Y chromosome from their fathers, and when Plebuch looked at her brother's results, darned if Bill's X chromosome wasn't lily white. Clearly, their mother had contributed no Jewish ancestry to her son.

The data from their mom's nephew revealed that he was a full first cousin, as expected sharing about 12.5 percent of his DNA with Plebuch. But the results from her dad's nephew, Pete Nolan, whose mother was Jim Collins' sister, revealed him to be a total stranger, genetically speaking. No overlap whatsoever with Plebuch or, by extension, with her father.

Plebuch and Wiggins came to the stunned conclusion that their dad was somehow not related to his own parents. John and Katie Collins were Irish Catholics, and their son was Jewish.

Surprise twist

If the mystery of their father didn't begin with his parents' life in Ireland, nor with his own time in the orphanage, Plebuch and her sister concluded it must have happened shortly after Jim was born. Unusually for the era, his mother gave birth not at home but at Fordham Hospital in the Bronx.

By this time, the sisters were using techniques to help adoptees try to find relatives in a vast universe of strangers' spit. Every time a site like 23andMe informed them of what Plebuch calls a DNA cousin on their Jewish side someone whose results suggested a likely cousin relationship they would ask to see that person's genome. If the person agreed, the site would reveal any places where their chromosomes overlapped.

The idea, Plebuch explains, was to find patterns in the data. A group of people who share segments on the same chromosome probably share a common ancestor. If Plebuch could find a group of relatives who all shared the same segment, she might be able to use that along with their family trees, family surnames, and ancestors' home towns in the old country to trace a path into her father's biological family.

And yet, the crack in the case came not through Plebuch's squad of helpful DNA cousins, but through a stranger with no genetic connection.

As administrator of Pete Nolan's 23andMe account, she had permission to check the list of his DNA relatives yet rarely did so, since new relatives rarely showed up. But one day in early 2015, she decided to check it. A stranger had just had her saliva processed, and she showed up as a close relative of Nolan.

Plebuch emailed the woman and asked whether she would compare genomes with Nolan. The woman agreed, and Plebuch could see the segments where her cousin and the stranger overlapped. Plebuch thanked her, and asked whether her results were what she expected.

I was actually expecting to be much more Ashkenazi than I am, the woman wrote. Her name was Jessica Benson, a North Carolina resident who had taken the test on a whim, hoping to learn more about her Jewish ethnicity. Instead, she wrote, she had discovered that I am actually Irish, which I had not expected at all.

Plebuch felt chills. She wrote back that her father had been born at Fordham Hospital on Sept.23, 1913. Had anyone in the Benson family been born on that date? Jessica replied that her grandfather, Phillip Benson, might have been born around that date.

She started combing through her list of baby names from the 1913 New York City Birth Index. No Benson born that day in the Bronx. But then, well after midnight, she found it: a Philip Bamson, born Sept.23 one of the names she had searched among her DNA cousins. This had to be Phillip Benson, his name misrecorded on his birth certificate.

This was a mistake that could only have been uncovered with DNA technology. Someone in the hospital back in 1913 had messed up. Somehow, a Jewish child had gone home with an Irish family, and an Irish child had gone home with a Jewish family. And the child who was supposed to be Phillip Benson had instead become Jim Collins.

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Sunscreen Made From DNA Would Last Forever | HuffPost – HuffPost

Posted: at 2:46 am

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A DNA-based sunscreen that not only stops harmful ultraviolet (UV) light, but also becomes more protective the longer you expose it to UV rays? Thats the dazzling premise behind a recent study published in the journal Science Reports.

While sunscreen isnt the only form of sun protection (theres always protective clothing and floppy hats), the reality is that most of us just skip it. A 2015 study in Journal of the American Academy of Dermatology found that only 14.3 percent of men and 29.9 percent of women routinely use sunscreen when they are in outside for more than an hour. This wouldnt be a problem, except, Ultraviolet light is a carcinogen, Guy German a biomedical researcher at Binghamton University in New York and an author on the study, tells PopSci. We know it can give you a tan, but it can also cause cancer as well.

While dermatoepidemiologists (scientists who study diseases of the skin) suspect that sunlight causes cancer because it damages DNA in our cells, German and his colleagues were looking at DNA in an entirely different way. They wondered what would happen if they exposed DNA film, essentially a thin sheet of the stuff, to the same kind of ultraviolet light we get from walking in sunshine.

If youve ever taken glue and spread it on a surface and then let it dry to create a sheet or film, then you understand the basics of the material the researchers made: They took a liquid solution of DNA, smeared it on a piece of glass, and let it dry to create the film. The DNA, in case you were wondering, comes from salmon sperm. It was not that we chose salmon sperm, says German. Its just one of the readily available DNA sources.

German, along with the lead author on the study, Alexandria Gasperini, then exposed the film to UVA and UVB light to see how much, if any, radiation the films would allow to pass. UVA light makes up around 95-percent of the suns radiative light; it can penetrate deep into the skin, has long-been thought to be a culprit in premature aging, and is increasingly believed to play a key role in the formation of skin cancer. UVB, the radiation that makes us tan (and burn), also plays a role in skin cancer.

This was a fundamental study to see how UV light interacts with DNA films, says German, Also, you know subsequently how the UV light can actually alter DNA films.

To measure these effects, the team used a device called a spectrophotometer, which allows them to control the amount and wavelength of light that they put through the films. A receptor on the other side measured how much of the light passed made it through. The DNA film did not allow up to 90 percent of UVB light and 20-percent of UVA light to cross through. Perhaps even more amazing: The DNA film seemed to grow strongerthat is, it seemed to allow less light to pass through the longer it was exposed to UV light. German and his team, however, arent sure if the films achieve this by absorbing light or reflecting it.

We discovered two possible mechanisms, says German to explain how the DNA films appear to achieving this feat. One is called hyperchromicity, that is the increased ability of DNA films to absorb UV light, but also we found that the results that we got suggest a crosslinking density of the molecules themselves.

Under a microscope, the films crystalline structure got denser, or developed more crosslinks, as it was exposed to more light. The results suggest that, if a film has more crosslinks, its potentially going to absorb or scatter more UV light.

As an added bonus, the team also found that when they coated the film on human skin samples procured from elective surgeries, it also helped the skin retain moisture.

To be clear, what German and his team tested is not sunscreen, at least not in the traditional sense of a liquid or paste smeared onto the skin. You cant pick this up at the supermarket, at least not anytime soon. But between the ecological and health concerns of chemical sunscreens, and the lack of efficacy of mineral sunscreens, what they uncovered, might make its way into products in the future. Who wouldnt want a sunscreen that you apply once? That grows stronger the longer you frolic in the sun? It would, in a sense, act as a sacrificial layer, taking one for the team and allowing your own skin to go unscathed.

This article appeared originally on Popular Science.

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Living to 125: Too much of a good thing? – Tribune-Review

Posted: at 2:46 am

Updated 6 hours ago

A 125-year life expectancy for human beings? I have zero desire to stick around that long.

Ah, yes, you speak of a debate among scientists over human longevity. I read about it at Business Insider. Some scientists argue that the maximum age humans may live is 115 years, whereas others argue that 125 years is possible.

A hundred and twenty-five years of watching Republicans and Democrats going at it? The heck with that.

Living is rife with challenges, to be sure. But living a long life has its upsides. Wouldn't you want to visit your parents and other family members for a lot more years than most of us are able? Wouldn't you like to see them all at a Sunday dinner several more times than most human beings are able?

Maybe with your family. My family has taken years off of my life!

I see, but wouldn't it be awesome if some of our finest human beings could stick around longer? Don Rickles, one of the greatest entertainers ever, died this year at 91. How great would it be to keep him around for two more decades?

True, but if Rickles were to stick around longer, that means annoying celebrities would stick around, too, and keep yapping at us every time a Republican becomes president.

There are other upsides to a longer life. What if we could keep our greatest minds around longer? Where would the world be if Einstein had another 25 years to unlock the mysteries of the universe?

But what if he figured out ways to extend human life even further, which would require me and the wife to have to keep coming up with new things to bicker about? Who has that kind of energy?

The downsides are a fair point. As people live longer, they could overburden government programs, such as Social Security. Where would we get all the money to support them?

How about we especially extend the lives of the rich so we can take them to the cleaners?

And living is expensive. If you live to 125, how will you pay for your housing and food and everyday expenses?

Thank goodness McDonald's is always hiring, but I for one have no desire to flip burgers at the age of 125.

The costs of medical care are too high for millions now. I imagine that at 125 years of age, one's medical bills would be difficult to manage.

Look, as a middle-aged guy, who is already showing signs of fatigue, here is what I know about living. Life is largely made up of colds, bills, speeding tickets and people who let you down. These experiences are connected together by a series of mundane tasks.

Did anyone tell you how cheerful you can be? Go on.

Well, these drudgeries are occasionally interrupted by a wonderful meal, a really good laugh with friends or a romantic evening with a lovely woman. Then the mundane stuff starts all over again. Who wants 125 years of that?

A lot of people do. The human life span has improved significantly in the past few generations. Millions are living healthy lives beyond the age of 80 today, and, when they were younger, few of them expected to live that long. Why not live relatively good lives until 125?

Because then I'd really worry about my slacker son.

Why?

He's 35 years old and still living at home. If we drastically extend life spans, my wife will have to tell him: Son, you're 100 years old! When are you going to move out of the basement and get a job?'

Tom Purcell, a freelance writer, lives in Library. His books include Misadventures of a 1970s Childhood and Wicked Is the Whiskey, a Sean McClanahan mystery. Visit him on the web at TomPurcell.com. Email him at: Tom@TomPurcell.com.

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Eczema and psoriasis treatment: THIS therapy could reduce the need for creams and tablets – Express.co.uk

Posted: at 2:45 am

Now, experts have said routine prescribing of UV light treatment for severe skin conditions could significantly reduce the use of steroid creams and tablets, according to new research from the University of Dundee.

Patients who experience the most severe forms of diseases such as psoriasis or eczema can find their lives affectged by their conditions.

Steroid creams are frequently prescribed but these can cause quite serious side effects and can prove inadequate to bring the disease under control.

In such instances patients may be referred to a dermatologist for more intensive treatment, which may take the forms of pills, injections or filtered UV light, known as phototherapy.

Experts from Dundee Universitys School of Medicine, examined the outcomes of 1800 patients with severe psoriasis who received UV treatment over a six-year period.

GETTY

They found that three-quarters of patients experienced significant improvements in their condition and that the need for steroid creams was reduced by 25 per cent.

Phototherapy involves safe, controlled delivery of narrow wavebands of ultraviolet radiation in specially constructed cabins.

It has been known to help skin disease sufferers for decades but this study is the first to demonstrate that its use can reduce the need for steroids in the treatment of psoriasis in routine practice and not just in a short-term clinical study.

Importantly, the findings also suggest that many patients can delay or avoid altogether the need for oral or injection treatments which can cause side effects such as gastric upset, liver dysfunction and infections.

Physicians have been using phototherapy or even direct sunlight to treat skin conditions for 50 years, said Dr Foerster.

We know that it helps patients with psoriasis and eczema but until now we did not know that it actually causes a reduction in the use of steroid creams and can reduce the need for patients to have their conditions controlled by tablets or injections.

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Getty Images/Cultura RF

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Resist the itch - Eczema is almost always itchy no matter where it occurs on the body and although it may be tempting to scratch affected areas of the skin, this should be avoided as much as possible

Phototherapy could reduce the need for eczema and psoriasis creams

These can work very well but can also have a downside.

The form of treatment we are talking about is targeted, non-dangerous exposure to filtered light to treat skin conditions that are so severe that they cant be contained with creams.

We were able to exploit a uniquely complete set of anonymised prescribing records that exists in Tayside and found that there was a very significant reduction in the amount of steroid cream prescribed to people who underwent phototherapy for up to 12 months after their treatment.

Access to phototherapy across the UK largely depends on a patients location.

Sadly phototherapy is not equally available around the UK, said Dr Foerster.

GETTY

Tablet treatments can be effective and safe with proper monitoring but it would be fantastic if everyone had the opportunity to try something that circumvents the need for any laboratory monitoring in the first place.

There are other risks resulting from a lack of access to phototherapy.

Sufferers of psoriasis or eczema may take matters into their own hands and seek out a sun-filled holiday or use sun beds.

I have seen this on several occasions and it brings with it the many well-known dangers arising from skin exposure.

The research is published in the journal PLOS ONE.

FIVE TIPS TO BEAT PSORIASIS

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Early gene-editing holds promise for preventing inherited diseases – The Jerusalem Post

Posted: at 2:45 am

The secret to healing what ails you lies within your own DNA. (photo credit:DREAMSTIME)

Scientists have, for the first time, corrected a disease-causing mutation in early-stage human embryos using gene editing.

The technique, which uses the CRISPR- Cas9 system, corrected the mutation for a heart condition at the earliest stage of embryonic development so that the defect would not be passed on to future generations.

It could pave the way for improved in vitro fertilization outcomes as well as eventual cures for some thousands of diseases caused by mutations in single genes.

The breakthrough and accomplishment by American and Korean scientists, was recently explained in the journal Nature. Its a collaboration between the Salk Institute, Oregon Health and Science University and South Koreas Institute for Basic Science.

Thanks to advances in stem cell technologies and gene editing, we are finally starting to address disease-causing mutations that impact potentially millions of people, said Prof. Juan Carlos Izpisua Belmonte of Salks gene expression lab and a corresponding author of the paper. Gene editing is still in its infancy, so even though this preliminary effort was found to be safe and effective, it is crucial that we continue to proceed with the utmost caution, paying the highest attention to ethical considerations.

Though gene-editing tools have the power to potentially cure a number of diseases, scientists have proceeded cautiously partly to avoid introducing unintended mutations into the germ line (cells that become eggs or sperm).

Izpisua Belmonte is uniquely qualified to speak on the ethics of genome editing because, as a member of the Committee on Human Gene Editing at the US National Academies of Sciences, Engineering and Medicine, he helped author the 2016 roadmap Human Genome Editing: Science, Ethics and Governance.

Hypertrophic cardiomyopathy is the most common cause of sudden death in otherwise healthy young athletes, and affects approximately one in 500 people. It is caused by a dominant mutation in the MYBPC3 gene, but often goes undetected until it is too late. Since people with a mutant copy of the MYBPC3 gene have a 50% chance of passing it on to their own children, being able to correct the mutation in embryos would prevent the disease not only in affected children but also in their descendants.

The researchers generated induced pluripotent stem cells from a skin biopsy donated by a male with Hypertrophic cardiomyopathy and developed a gene-editing strategy based on CRISPR-Cas9 that would specifically target the mutated copy of the MYBPC3 gene for repair. The targeted mutated MYBPC3 gene was cut by the Cas9 enzyme, allowing the donors cells own DNA -repair mechanisms to fix the mutation during the next round of cell division by using either a synthetic DNA sequence or the non-mutated copy of MYBPC3 gene as a template.

Using IVF techniques, the researchers injected the best-performing gene-editing components into healthy donor eggs that are newly fertilized with donors sperm. All the cells in the early embryos are then analyzed at single-cell resolution to see how effectively the mutation was repaired.

They were surprised by the safety and efficiency of the method. Not only were a high percentage of embryonic cells get fixed, but also gene correction didnt induce any detectable off-target mutations and genome instability major concerns for gene editing.

The researchers also developed an effective strategy to ensure the repair occurred consistently in all the cells of the embryo, as incomplete repairs can lead to some cells continuing to carry the mutation.

Even though the success rate in patient cells cultured in a dish was low, we saw that the gene correction seems to be very robust in embryos of which one copy of the MYBPC3 gene is mutated, said Jun Wu, a Salk staff scientist and one of the authors.

This was in part because, after CRISPR- Cas9 mediated enzymatic cutting of the mutated gene copy, the embryo initiated its own repairs. Instead of using the provided synthetic DNA template, the team surprisingly found that the embryo preferentially used the available healthy copy of the gene to repair the mutated part.

Our technology successfully repairs the disease-causing gene mutation by taking advantage of a DNA repair response unique to early embryos, said Wu.

The authors emphasized that although promising, these are very preliminary results and more research will need to be done to ensure no unintended effects occur.

Our results demonstrate the great potential of embryonic gene editing, but we must continue to realistically assess the risks as well as the benefits, they added.

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Episode 271: BK gives his politically incorrect take on this week’s news – SOFREP (press release) (subscription)

Posted: at 2:44 am

Guest Name(s): BK

Between BKs weekly News Roundup articles and his own News Roundup podcasts, its safe to say hes grown a cult following of readers and listeners who enjoy his no-holds barred take on the news that doesnt ever cater to the culture of political correctness. This appearance on SOFREP Radio is no different as we get into everything from healthcare to the transgender issue, as well as some of the pop culture related news of the week.

B.K. also touches on some of the training needed to become an Air Force PJ, and what hes been up to in San Diego. We have some good laughs that were sure youll enjoy. Also, we check the inbox at [emailprotected] and urge you to keep the emails and voice memos coming!

If you liked this article, tell someone about it

Ian Scotto is an award winning radio producer who has had on-air and behind the scenes radio experience since 2006. He holds a degree in Radio from Hofstra University. He got his start at WRHU, the flagship station of The New York Islanders, where he hosted and did imaging for various shows on the platform, and for the station at large. He later worked for Sirius XM on various radio programming including Fangoria Radio with legendary rock icon Dee Snider, The Wilkow Majority with Andrew Wilkow, and produced Senator Bill Bradley's American Voices. He is now the producer and co-host for the leading Special Operations military podcast, SOFREP Radio, with best selling authors Brandon Webb (former Navy SEAL sniper instructor) and Jack Murphy (former Army Ranger and Green Beret.) Ian can also be found on Appetite for Distortion talking Guns N' Roses and doing voiceover work for various clients. Outside of radio, he is a fitness enthusiast with a focus on weight training and running.

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Flair for bragging, politically incorrect – The Guam Daily Post

Posted: at 2:44 am

WASHINGTON Leaked transcripts of phone conversations between Donald Trump and two world leaders show the U.S. president relentlessly focused on his political image and underscore some of the difficulty he has had navigating foreign affairs.

The conversations between Trump and Australian Prime Minister Malcolm Turnbull and Mexican President Enrique Pena Nieto during Trump's first week in office offer a window into the president's occasionally fraught relationships with other world leaders and his approach to negotiating toward his goals.

Full transcripts released

While some details had been previously reported, full transcripts of the calls, produced by White House staff, were published Thursday by The Washington Post. The Post didn't reveal how it obtained the transcripts.

Revelations include Trump describing his proposed border wall to Mexico's president as "the least important thing we are talking about, but politically this might be the most important." He implores Pena Nieto to stop saying publicly that Mexico won't pay for its construction, arguing they could work out a deal so that the cost would "come out in the wash."

In his call with Turnbull, the president vents about the Australian prime minister's insistence that Trump honor a deal struck by former President Barack Obama's administration to allow 1,250 refugees housed by Australia into the U.S.

"This is going to kill me," Trump told Turnbull, calling the deal "stupid" and saying it "will make me look terrible." The president goes on to describe the phone call which capped a marathon day in which he also spoke to the leaders of Russia, Germany, Japan, and France as his worst call of the bunch.

"I have had it," Trump tells Turnbull. "I have been making these calls all day and this is the most unpleasant call all day. (Russian President Vladimir) Putin was a pleasant call. This is ridiculous."

No comment from the White House

The White House declined to comment when asked about the transcripts. But the release of the documents, compiled by White House staff and circulated within national security departments and agencies, demonstrates that the administration is still struggling to tamp down on leaks that appear intended to damage his presidency. Administration officials have previously expressed frustration with the revelations, saying they impair the ability of the president to candidly speak with world leaders.

The conversations are peppered with the president's signature braggadocio and flair for the politically incorrect.

He tells the Mexican president that he "won New Hampshire because New Hampshire is a drug-infested den." Democrat Hillary Clinton won New Hampshire's electoral votes in the general election, though Trump did win the Republican primary there. The comment has drawn criticism from Democratic lawmakers in the state, with Senator Maggie Hassan calling the characterization "disgusting" and Senator Jeanne Shaheen saying Trump owed New Hampshire an apology.

No norms of international diplomacy

Trump also claims to have earned the votes of a "large percentage of Hispanic voters," brags about the size of his campaign crowds, and offers to help "big league" with Mexico's "pretty tough hombres" responsible for the drug trade.

The transcripts show Pena Nieto and Turnbull struggling to reconcile Trump's words with the norms of international diplomacy, the actual terms of trade and migration deals, and his publicly professed positions.

When Pena Nieto says that he will continue to be firm in saying Mexico could not pay for the wall, Trump implores him to not say so to the media.

"The press is going to go with that and I cannot live with that," Trump said. "You cannot say that to the press because I cannot negotiate under those circumstances."

Pena Nieto's office subsequently said in a statement that the two leaders agreed to stop publicly talking about who would pay for the wall. But Trump said just before meeting with the Mexican president at the G-20 summit last month in Germany that Mexico "absolutely" should pay for the barrier, though he didn't raise the issue with Pena Nieto.

At one point in their phone call, Trump also seems to threaten Mexico with a border tax on imports, saying he was contemplating 35 percent tariffs on products "ripped from their foundation" in the U.S. and moved to Mexico, with lower rates imposed on other goods. Former White House press secretary Sean Spicer floated that idea to reporters days later, only for the White House to retreat publicly from the idea.

Foreshadowing of world reception

Pena Nieto says he is "surprised" by Trump's tariff idea, saying it deviated from the staff-level discussions between their nations.

"The proposal that you are making is completely new, vis-a-vis the conversations our two teams have been having," the Mexican president said.

The conversations also foreshadow some of the broader foreign policy headaches that have plagued the president's first six months in office.

Trump got a frosty reception at a pair of world summits in Europe, with traditional U.S. allies expressing frustration with his willingness to go back on deals negotiated by the Obama administration. Trump's decision to withdraw from the Paris climate accord left the U.S. isolated during that discussion at last month's G-20 summit in Germany.

The U.S. president's focus on catchphrases and threats has also proven a sticking point among traditional allies. Germany's Angela Merkel has signaled frustration with Trump's insistence that her country, whose trade relations with the U.S. are governed by a broader European deal, is exploiting U.S.-German trade. The president's insistent suggestions that NATO allies owe back payments to the alliance because of a mutual agreement for each country to reach a certain defense spending goal has also earned eye-rolls within Europe.

Trump's gruff and occasionally confrontational manner has also ruffled feathers and led to memorable diplomatic moments, from shoving his way to the front of a G-20 family photo to awkward handshakes with other leaders.

And while Trump frequently said on the campaign trail that he would use his business acumen to pressure China into curbing North Korea's nuclear and ballistic missile ambitions, provocations have continued. Earlier this week, Trump tweeted he was "very disappointed " with China over the issue.

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Transhumanism could lead to immortality for the elite – Gears Of Biz

Posted: at 2:43 am

The rapid development of so-called NBIC technologies nanotechnology, biotechnology, information technology and cognitive science are giving rise to possibilities that have long been the domain of science fiction.

Disease, ageing and even death are all human realities that these technologies seek to end.

They may enable us to enjoy greater morphological freedom we could take on new forms through prosthetics or genetic engineering.

Or advance our cognitive capacities.

We could use brain-computer interfaces to link us to advanced artificial intelligence (AI).

Nanobots could roam our bloodstream to monitor our health and enhance our emotional propensities for joy, love or other emotions.

Advances in one area often raise new possibilities in others, and this convergence may bring about radical changes to our world in the near-future.

Transhumanism is the idea that humans should transcend their current natural state and limitations through the use of technology that we should embrace self-directed human evolution.

If the history of technological progress can be seen as humankinds attempt to tame nature to better serve its needs, transhumanism is the logical continuation: the revision of humankinds nature to better serve its fantasies.

As David Pearce, a leading proponent of transhumanism and co-founder of Humanity+, says:

If we want to live in paradise, we will have to engineer it ourselves.

If we want eternal life, then well need to rewrite our bug-ridden genetic code and become god-like only hi-tech solutions can ever eradicate suffering from the world.

Compassion alone is not enough.

But there is a darker side to the naive faith that Pearce and other proponents have in transhumanism one that is decidedly dystopian.

There is unlikely to be a clear moment when we emerge as transhuman.

Rather technologies will become more intrusive and integrate seamlessly with the human body.

Technology has long been thought of as an extension of the self.

Many aspects of our social world, not least our financial systems, are already largely machine-based.

There is much to learn from these evolving human/machine hybrid systems.

Yet the often Utopian language and expectations that surround and shape our understanding of these developments have been under-interrogated.

The profound changes that lie ahead are often talked about in abstract ways, because evolutionary advancements are deemed so radical that they ignore the reality of current social conditions.

In this way, transhumanism becomes a kind of techno-anthropocentrism, in which transhumanists often underestimate the complexity of our relationship with technology.

They see it as a controllable, malleable tool that, with the correct logic and scientific rigour, can be turned to any end.

In fact, just as technological developments are dependent on and reflective of the environment in which they arise, they in turn feed back into the culture and create new dynamics often imperceptibly.

Situating transhumanism, then, within the broader social, cultural, political, and economic contexts within which it emerges is vital to understanding how ethical it is.

Max More and Natasha Vita-More, in their edited volume The Transhumanist Reader, claim the need in transhumanism for inclusivity, plurality and continuous questioning of our knowledge.

Yet these three principles are incompatible with developing transformative technologies within the prevailing system from which they are currently emerging: advanced capitalism.

One problem is that a highly competitive social environment doesnt lend itself to diverse ways of being.

Instead it demands increasingly efficient behaviour.

Take students, for example.

If some have access to pills that allow them to achieve better results, can other students afford not to follow?

This is already a quandary.

Increasing numbers of students reportedly pop performance-enhancing pills.

And if pills become more powerful, or if the enhancements involve genetic engineering or intrusive nanotechnology that offer even stronger competitive advantages, what then?

Rejecting an advanced technological orthodoxy could potentially render someone socially and economically moribund (perhaps evolutionarily so), while everyone with access is effectively forced to participate to keep up.

Going beyond everyday limits is suggestive of some kind of liberation.

However, here it is an imprisoning compulsion to act a certain way.

We literally have to transcend in order to conform (and survive).

The more extreme the transcendence, the more profound the decision to conform and the imperative to do so.

The systemic forces cajoling the individual into being upgraded to remain competitive also play out on a geo-political level.

One area where technology R&D has the greatest transhumanist potential is defence.

DARPA (the US defence department responsible for developing military technologies), which is attempting to create metabolically dominant soldiers, is a clear example of how vested interests of a particular social system could determine the development of radically powerful transformative technologies that have destructive rather than Utopian applications.

The rush to develop super-intelligent AI by globally competitive and mutually distrustful nation states could also become an arms race.

In Radical Evolution, novelist Verner Vinge describes a scenario in which superhuman intelligence is the ultimate weapon.

Ideally, mankind would proceed with the utmost care in developing such a powerful and transformative innovation.

There is quite rightly a huge amount of trepidation around the creation of super-intelligence and the emergence of the singularity the idea that once AI reaches a certain level it will rapidly redesign itself, leading to an explosion of intelligence that will quickly surpass that of humans (something that will happen by 2029 according to futurist Ray Kurzweil).

If the world takes the shape of whatever the most powerful AI is programmed (or reprograms itself) to desire, it even opens the possibility of evolution taking a turn for the entirely banal could an AI destroy humankind from a desire to produce the most paperclips for example?

Its also difficult to conceive of any aspect of humanity that could not be improved by being made more efficient at satisfying the demands of a competitive system. It is the system, then, that determines humanitys evolution without taking any view on what humans are or what they should be.

One of the ways in which advanced capitalism proves extremely dynamic is in its ideology of moral and metaphysical neutrality.

As philosopher Michael Sandel says: markets dont wag fingers.

In advanced capitalism, maximising ones spending power maximises ones ability to flourish hence shopping could be said to be a primary moral imperative of the individual.

Philosopher Bob Doede rightly suggests it is this banal logic of the market that will dominate:

If biotech has rendered human nature entirely revisable, then it has no grain to direct or constrain our designs on it.

And so whose designs will our successor post-human artefacts likely bear?

I have little doubt that in our vastly consumerist, media-saturated capitalist economy, market forces will have their way.

So the commercial imperative would be the true architect of the future human.

Whether the evolutionary process is determined by a super-intelligent AI or advanced capitalism, we may be compelled to conform to a perpetual transcendence that only makes us more efficient at activities demanded by the most powerful system.

The end point is predictably an entirely nonhuman though very efficient technological entity derived from humanity that doesnt necessarily serve a purpose that a modern-day human would value in any way.

The ability to serve the system effectively will be the driving force.

This is also true of natural evolution technology is not a simple tool that allows us to engineer ourselves out of this conundrum.

But transhumanism could amplify the speed and least desirable aspects of the process.

For bioethicist Julian Savulescu, the main reason humans must be enhanced is for our species to survive.

He says we face a Bermuda Triangle of extinction: radical technological power, liberal democracy and our moral nature.

As a transhumanist, Savulescu extols technological progress, also deeming it inevitable and unstoppable.

It is liberal democracy and particularly our moral nature that should alter.

The failings of humankind to deal with global problems are increasingly obvious.

But Savulescu neglects to situate our moral failings within their wider cultural, political and economic context, instead believing that solutions lie within our biological make up.

Yet how would Savulescus morality-enhancing technologies be disseminated, prescribed and potentially enforced to address the moral failings they seek to cure?

This would likely reside in the power structures that may well bear much of the responsibility for these failings in the first place.

Hes also quickly drawn into revealing how relative and contestable the concept of morality is:

We will need to relax our commitment to maximum protection of privacy.

Were seeing an increase in the surveillance of individuals and that will be necessary if we are to avert the threats that those with antisocial personality disorder, fanaticism, represent through their access to radically enhanced technology.

Such surveillance allows corporations and governments to access and make use of extremely valuable information.

In Who Owns the Future, internet pioneer Jaron Lanier explains:

Troves of dossiers on the private lives and inner beings of ordinary people, collected over digital networks, are packaged into a new private form of elite money

It is a new kind of security the rich trade in, and the value is naturally driven up. It becomes a giant-scale levee inaccessible to ordinary people.

Crucially, this levee is also invisible to most people.

Its impacts extend beyond skewing the economic system towards elites to significantly altering the very conception of liberty, because the authority of power is both radically more effective and dispersed.

Foucaults notion that we live in a panoptic society one in which the sense of being perpetually watched instils discipline is now stretched to the point where todays incessant machinery has been called a superpanopticon.

The knowledge and information that transhumanist technologies will tend to create could strengthen existing power structures that cement the inherent logic of the system in which the knowledge arises.

This is in part evident in the tendency of algorithms toward race and gender bias, which reflects our already existing social failings.

Information technology tends to interpret the world in defined ways: it privileges information that is easily measurable, such as GDP, at the expense of unquantifiable information such as human happiness or well-being.

As invasive technologies provide ever more granular data about us, this data may in a very real sense come to define the world and intangible information may not maintain its rightful place in human affairs.

Existing inequities will surely be magnified with the introduction of highly effective psycho-pharmaceuticals, genetic modification, super intelligence, brain-computer interfaces, nanotechnology, robotic prosthetics, and the possible development of life expansion.

They are all fundamentally inegalitarian, based on a notion of limitlessness rather than a standard level of physical and mental well-being weve come to assume in healthcare.

Its not easy to conceive of a way in which these potentialities can be enjoyed by all.

Sociologist Saskia Sassen talks of the new logics of expulsion, that capture the pathologies of todays global capitalism.

The expelled include the more than 60,000 migrants who have lost their lives on fatal journeys in the past 20 years, and the victims of the racially skewed profile of the increasing prison population.

In Britain, they include the 30,000 people whose deaths in 2015 were linked to health and social care cuts and the many who perished in the Grenfell Tower fire.

Their deaths can be said to have resulted from systematic marginalisation.

Unprecedented acute concentration of wealth happens alongside these expulsions.

Advanced economic and technical achievements enable this wealth and the expulsion of surplus groups.

At the same time, Sassen writes, they create a kind of nebulous centrelessness as the locus of power:

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Transhumanism could lead to immortality for the elite - Gears Of Biz

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The risk of a transhumanist future – BioEdge

Posted: at 2:43 am

Transhumanism has received significant media attention in recent times not in the least because the one of the movements leaders, Zoltan Istvan, ran for president in 2016 US elections.

But a British PhD candidate has warned of the darker side of a transhumanist future.

Sociologist Alex Thomas of East London University believes that transhumanism will further enforce a societal obsession with progress and efficiency at the expense of social justice and environmental sustainability. In an article published this week in The Conversation, Thomas argues that unbridled technological progress, in which technology become more intrusive and integrate seamlessly with the human body, could lead to a loss of basic societal values such as compassion and a concern for the environment.

Thomas interweaves examples ranging from new military technologies to powerful enhancement medications, arguing that, rather than assisting humanity, these technologies could potentially lead to a mechanisation of humanity and facilitate a subtle form of authoritarian control.

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The risk of a transhumanist future - BioEdge

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Saudi Arabia must do something about its barbaric human rights practices – Washington Post

Posted: at 2:42 am

PROFOUND CHANGE may someday come to Saudi Arabia. The new crown prince, Mohammed bin Salman, last year offered a soaring blueprint for modernizing the kingdom, Vision 2030, that promised to build a thriving country in which all citizens can fulfill their dreams, hopes and ambitions. The document also vowed to build a tolerant country with moderation as its method that is a global investment powerhouse and an epicenter of trade and the gateway to the world.

This is a tall order, especially in a kingdom where change has been agonizingly slow. The crown prince clearly wants to move Saudi Arabia toward a future not beholden to oil. But in one important respect Saudi Arabia remains mired in the dark ages: Human rights are trampled upon, and free expression crushed. This is entirely out of sync with ambitions to create a thriving and modern state.

The latest sign of this backwardness is the fate of 14 Saudi men, all from the countrys Shiite minority, who are facing execution for allegedly staging protests in the kingdom. As The Posts Sudarsan Raghavan reported , the men are charged with terrorism-related offenses, but human rights groups say confessions from the defendants were extracted under torture. Among those condemned to death are Mujtabaa al-Sweikat, who, after attending pro-democracy protests inspired by the Arab Spring in 2011 and 2012, was arrested at an airport in December 2012 as he was leaving the country to visit the campus of Western Michigan University, which he was thinking of attending. Seventeen years old at the time, he was not given a reason for his arrest and has been in prison ever since, convicted without having access to legal representation, according to human rights activists. In a July 22 statement, Western Michigan faculty and administrators said Mr. Sweikat was subject to sleep deprivations, beatings, cigarette burns, solitary confinement and others forms of torture or suffering. He was sentenced to death on the sole basis of a confession extracted by torture, they added, citing the findings of the U.N. human rights office.

If only this were an isolated case. Another travesty surrounds the fate of blogger Raif Badawi, who has been jailed since 2012 following his online appeal for a more liberal and secular society. His sentence was 10 years in prison and 1,000 lashes, of which he has been given 50 lashes. Mr. Badawis aspirations were also for a tolerant and moderate Saudi Arabia, but that was a threat to the kingdoms conservative Islamic establishment. His treatment offers a reason to doubt Crown Prince Salmans commitment to the goals of Vision 2030.

President Trump steered clear of human rights in his May visit to Saudi Arabia, but the kingdoms horrors have not vanished. If Saudi leaders really want to embrace modernism, they could start by reversing the barbaric death sentences imposed on 14 Shiite men for taking part in demonstrations.

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Saudi Arabia must do something about its barbaric human rights practices - Washington Post

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