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Category Archives: Transhuman News

Immigration advocates seek DNA samples from NYC migrant families to help ID missing, dead relatives – amNY

Posted: August 6, 2017 at 4:46 pm

A special team of immigration advocates, working in collaboration with forensic experts, will be in Manhattan later this month to get DNA samples from New York City area immigrant families whose relatives are missing and may have died crossing the deserts of the American southwest.

While the death of 10 migrants in a sweltering tractor trailer in San Antonio a few weeks ago is the latest example of perils associated with human smuggling, thousands of immigrants have been turning up dead for years as they try to cross the U.S. border areas of Arizona and Texas on foot, experts say.

I would characterize the scope of the loss of human life on the border as catastrophic, said Robin Reineke, co-founder of the nonprofit Colibri Center for Human Rights in Tucson, Arizona, the group organizing DNA collection effort in the city. The true number of dead and missing are unknown, but are easily above 10,000.

Another expert said forensic teams excavating cemeteries in Texas sometimes find four bodies in a grave. There are huge numbers of deaths which nobody is paying attention to, said Lori Baker, an official of Baylor University who in 2003 started the Reuniting Families Project to help identify remains of immigrants.

Reineke said that her staff has information that more than 200 New York City families are trying to find missing relatives with whom they lost contact during smuggling attempts. Colibri staff will be in Manhattan from Friday to Aug. 15. Because of concerns about the undocumented status of some of the families, Colibri is not identifying the sampling location.

Colibris push to get DNA reference samples from New York families is part of a wider effort to overcome the reluctance of immigrants to cooperate with law enforcement agencies that have the ability to check DNA profiles with those already on file from retrieved bodies. In the past, the University of North Texas would generate DNA profiles to compare with the law enforcement database known as CODIS, which Reineke said requires genetic profiles be submitted from police agencies.

But early this year, the National Institutes of Justice diverted funding from DNA testing of missing migrants to the screening of a nationwide backlog of rape kits.

Colibri gets around the CODIS restriction by sending its collected samples to the private Bode Cellmark Forensics in Virginia. Bode Cellmark has the largest private collection of DNA profiles for unidentified bodies found in Arizona, Reineke said. She explained that Hesss office, in collaboration with the Mexican Consulate, has sent samples for all unidentified remains to Bode Cellmark since about 2002, creating a large database for comparison.

In New York City, the chief medical examiner in 2014 got a DNA hit and identified Manuel Merchan, a 33-year-old man from Ecuador whose remains were found in Brook County, Texas, in 2015. Merchans family lives in Westchester County.

In Pima County, Arizona, the remains of 2,600 migrants, known as undocumented border crossers, have been collected since 2002, said Dr. Greg Hess, the countys medical examiner. Hess said he handled 154 bodies last year, a relatively small part of his annual caseload of 3,000.

It is about the same type of situation like having a plane crash a year, Hess said of the dead migrant workload.

Many remains are nothing more than skeletons and sometimes just bone fragments. Some carry identification documents but they may be forgeries. Dental records are often of no use since some countries have poor record keeping practices. Tattoos, styles of clothing and fingerprints sometimes provide leads.

Bones may be scattered even ants may take fragments into their tunnels, said Jason DeLeon, an anthropologist at the University of Michigan who studies migrant deaths.

During one hike through the Arizona desert, De Leon and his colleagues came across the decomposing body of an Ecuadorean woman. The remains were identified by fingerprints as that of Carmita Maricela Zhagui, 28, who was trying to join her family in Queens, De Leon said.

People interested in giving DNA samples to the Colibri Center during its New York City area initiative 15 can contact the organization by sending an email to info@colibricenter.org.

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DNA analysis helps add branches to family tree – Altoona Mirror

Posted: at 4:46 pm

Deoxryrobonucleic Acid (commonly known as DNA) is one of the latest and most revealing tools that wannabe genealogists like me have to trace our ancestors.

I have done family tree explorations using the usual means of research: documents, books and family lore. By those means, I traced my ancestors from western Europe to America and then to Bedford and Blair counties. DNA analysis has allowed me to look back many centuries before.

Each of us has a unique DNA makeup that can be traced back to the beginning of mankind. The DNA of my Y chromosome has been passed down almost unchanged from fathers to sons. Document research on my family dates to one Daniel Augustus Wentz, born in 1809 in Bedford County. Everyone before him is unknown to me. DNA analysis offered the possibility of learning about family members before 1809.

About 10 years ago, the National Geographic Society announced a project called Genographic, in which it compared DNA saliva samples from people like me to places in the world that had matching samples. In that way, they could provide a world map showing the route my ancestors took to reach America.

In the National Geographic undertaking, my saliva DNA was coded and then plugged into a chart that showed where similar DNA was distributed throughout the world. For example, if my DNA was coded as 9X, then a computer looked for where other 9Xs are located. I knew my forefather immigrated from western Europe, but where did his forefather come from?

The source of my 9X DNA originated in what is present-day Tanzania, in east Africa. Then my ancestors migrated north to what is Egypt, through Israel and Turkey and westward across Europe. In other words, as my ancestors moved from Africa millennia ago, probably trying to escape famine or some form of predator, they left behind along the route family members whose DNA exist today in those areas of Africa, the Middle East and Europe.

A more recent DNA project was sponsored by Ancestry.com and used DNA saliva samples to pinpoint ethnicity (the nationalities of my ancestors and the geographic areas they are most connected with).

This Ancestry DNA analysis established my familys primary habitats thousands of years ago as 68 percent Western Europe (Germany), with 15 percent Irish and 7 percent Italy/Greece. The Irish and Italy/Greece migrations were news to me.

As for the place in America that claims the most Wentz DNA, the Ancestry map shows it to be western Pennsylvania. That finding confirmed my confidence in the National Geographic and Ancestry analyses because all they knew about me personally was my primary residence in Virginia. Knowing that my family lived in the Blair/Bedford area for more than two centuries, an analysis claiming a significant concentration anywhere else in America would have raised huge suspicions in my mind.

The most interesting finding of the Ancestry analysis is that it is likely my first German ancestor arrived in America during the colonial period from 1607 to 1776. That is much earlier than I imagined, and is worth knowing and passing along to my children and grandchildren.

James Wentz writes a monthly column for the Mirror.

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Therapy for Psoriasis May Not be Triggering Inflammatory Bowel Disease – Medical News Bulletin

Posted: at 4:45 pm

A currently approved antibody for the treatment of plaque psoriasis, ixekizumab, targets a cytokine that may also play a role in the pathogenesis of inflammatory bowel disease. This has led to concerns that ixekizumab increases the occurrence of inflammatory bowel disease in patients with psoriasis. A recent study published in the American Journal of Dermatology have now put those concerns to rest.

Plaque psoriasis is an inflammatory skin disorder, characterized by the appearance of raised red scales, which are often itchy and painful. Whats worse is that psoriasis has a significant genetic overlap with inflammatory bowel disease (IBD), and patients often develop IBD as a co-morbidity. Crohns disease and ulcerative colitis are the two most common manifestations of IBD, characterized by chronic and recurrent inflammation of the intestines.

Animal and human studies have suggested a potential role of the cytokine interleulin-17 (IL-17) in the pathogenesis of IBD, although the results have often been confounding. So far, clinical trials using antagonists of IL-17A have failed to show efficacy in treating Crohns disease, or worsened prognosis.

Ixekizumab, an antibody against IL-17A, is an effective monoclonal antibody approved for the treatment of plaque psoriasis. Considering the genetic overlap between psoriasis and IBD, and prior reports of adverse events in Crohns patients receiving IL-17A antagonists, Eli Lilly and Company, the pharmaceutical giant that helped developed ixekizumab, conducted a study to gain a better understanding of IBD incidence in psoriasis patients treated with ixekizumab.

The company set up an independent external committee to look at data from 4029 patients with moderate to severe psoriasis who have received ixekizumab. Participants were previously enrolled in one of 7 different randomized clinical trials for ixekizumab. Adjudication of IBD was performed according to an internationally recognized classification system, combining reviews of radiographic, endoscopic, pathological, clinical and laboratory features.

Published in the American Journal of Dermatology, the study found that rates of new IBD cases (comprising both Crohns disease and ulcerative colitis) were uncommon (<1%) in psoriasis patients receiving ixekizumab. They reported that flares of preexisting disease were also rare.

The authors, however, acknowledged one major limitation of the report: the post-hoc nature of the adjudication process, which may have limited the amount of data collection necessary for IBD confirmation. Also, no information on patient or family history of IBD was collected at the time of the trials. Furthermore, the study lacked information on the duration of earlier therapies that may have led to IBD symptoms i.e. before exposure to ixekizumab.

Albeit, the authors suggest that dermatologists monitor patients with concomitant psoriasis and IBD who are receiving IL-17 antibody therapy and advocate for providing full warnings and precautions when prescribing IL-17A antagonists.

Written By: Debapriya Dutta, PhD

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Kashmiri doctor helps gene editing of human embryos in US – Hindustan Times

Posted: at 4:45 pm

For the first time, genetically modified human embryos have been developed in the US and Kashmir-born doctor Sanjeev Kaul has played a lead role in this breakthrough.

Scientists have now demonstrated an effective way of using a gene-editing tool to correct a disease-causing gene mutation in human embryos and stop it from passing to future generations.

Though this is not a full-fledged start of a revolution of having designer babies, the first steps, however, have been laid. China attempted this earlier.

A team of scientists has altered human embryos using a new technique called CRISPR CAS9 that edits genes and in this case it helped remove a fatal mutation that leads to heart attacks.

This now opens up an ethical Pandoras Box if germline repairs and enhancements may become a thing in vogue.

As of now, the human embryos were not implanted in humans. But this now opens up exciting prospects of the world having designer babies soon.

The research published in British journal Nature shows the first genetically modified human embryos made in America.

A team of South Korean, Chinese and American scientists has identified how they could edit out a faulty gene that causes heart attacks in later life due to the thickening of heart walls.

One of the team members is Dr Kaul, who was born in Kashmir, studied in New Delhi and later immigrated to America.

Although the rare heart mutation affects men and women of all ages, it is a common cause of sudden cardiac arrest in young people, and it could be eliminated in one generation in a particular family, said co-author Kaul, a professor of medicine (cardiovascular medicine) in the OHSU School of Medicine and director of the OHSU Knight Cardiovascular Institute.

Thanks to advances in stem cell technologies and gene editing, we are finally starting to address disease-causing mutations that impact potentially millions of people, says Juan Carlos Izpisua Belmonte, a professor in California-based Salk Institutes Gene Expression Laboratory and a corresponding author of the paper.

Gene editing is still in its infancy so even though this preliminary effort was found to be safe and effective, it is crucial that we continue to proceed with the utmost caution, paying the highest attention to ethical considerations.

CRISPR CAS9 or Clustered Regularly Interspaced Short Palindromic Repeats is a kind of a precise molecular scissor the scientists use to edit faulty genes.

Only selected healthy embryos were allowed to grow further that too only for a few days. The embryos were not implanted in humans.

The big step forward is that a higher percentage embryos were found to have been repaired in this American experiment than earlier attempts.

CRISPR holds promise for correcting mutations in the human genome to prevent genetic disease. Using an enzyme called Cas9, it is possible to snip a specific target sequence on a mutant gene.

The new study found that human embryos effectively repair these breaks in the mutant gene using the normal copy of this gene from a second parent as a template.

The resulting embryos contain now repaired, mutation-free copies of this gene.

The technique already has been used in animals for generating mutant models; however, the new study is the first to demonstrate that technique can be used in human embryos to convert mutant genes back to normal.

The study also demonstrated a way for overcoming a crucial problem in genome editing in embryos known as mosaicism.

Mosaicism refers to an outcome when not all cells in a multicellular embryo get repaired and some cells still carry a mutation.

Every generation on would carry this repair because we have removed the disease-causing gene variant from that familys lineage, said senior author Shoukhrat Mitalipov, PhD, who directs the Center for Embryonic Cell and Gene Therapy at Oregon Health and Science University (OHSU), in Portland, Oregon, USA.

By using this technique, it is possible to reduce the burden of this heritable disease on the family and eventually the human population.

The study provides new insight into a technique that could apply to thousands of inherited genetic disorders affecting millions of people worldwide.

The gene-editing technique described in this study, done in concert with in vitro fertilisation, could provide a new avenue for people with known heritable disease-causing genetic mutations to eliminate the risk of passing the disease to their children.

If proven safe, this technique could potentially decrease the number of cycles needed for people trying to have children free of genetic disease, said co-author Paula Amato, associate professor of obstetrics and gynaecology in the OHSU School of Medicine.

Designer babies could be in the offing.

Our results demonstrate the great potential of embryonic gene editing, but we must continue to realistically assess the risks as well as the benefits, adds Belmonte.

In this landmark study, the researchers worked with healthy donated human oocytes and sperm carrying the genetic mutation that causes cardiomyopathy or the thickening of heart walls.

Embryos created in this study were used to answer pre- clinical questions about safety and effectiveness. The study noted that genome editing approaches must be further optimised before moving to clinical trials.

This research significantly advances scientific understanding of the procedures that would be necessary to ensure the safety and efficacy of germline gene correction, said Daniel Dorsa, senior vice president for research at OHSU.

The ethical considerations of moving this technology to clinical trials are complex and deserve significant public engagement before we can answer the broader question of whether its in humanitys interest to alter human genes for future generations.

Existing ethical guidelines did not permit the team to implant the genetically modified human embryos into women.

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Comic Chatbot Errors in China Mask Serious Corporate Caving on Censorship – TheStreet.com

Posted: at 4:44 pm

Tencent, Microsoft MSFT and Action Alerts PLUScharity portfolio holding Apple (AAPL) have all in the last five days learned the hard way that in China, software is power.

Tech companies that might put up a fight elsewhere over content restrictions or access to their products crumble in the face of the Communist Party. With Web restrictions tightening in China, the issue is only going to gain in prominence, and the ranks of companies caving are likely to grow.

Comically, Tencent (TCEHY) has removed chatbots developed by Microsoft and Beijing-based Turing Robot after they started giving so-called unpatriotic answers.

The BabyQ bot co-developed by Beijing-based Turing Robot answered the question "Do you love the Communist Party?" with "No," the Financial Times reports. The XiaoBing bot from Microsoft (MSFT) reportedly told users: "My China dream is go to America."

On a more serious note, Applecame under fire for removing VPN-related apps from its app store. VPNs, or Virtual Private Networks, can help Chinese citizens get around the stringent governmentcontrols of Web content to access overseas information.

Apple says it was merely complying with tightened Chinese regulations. But there was none of the defiance that Apple showed when it fought back on home soil against a court order to help the FBI unlock an iPhone, as the agency investigated the San Bernardino terrorist attack.

The president of Golden Frog, which saw its privacy software VyprVPN knocked off the Apple app tree in China, said it was "disappointed" Apple bowed to pressure from Beijing, without even citing the specific law that makes a VPN illegal.

"We view access to Internet in China as a human rights issue, and I would expect Apple to value human rights over profits," Sunday Yokubaitis told The New York Times. Golden Frog filed an amicus brief in support of Apple's action against the FBI.

The pulling of the chatbots is no surprise. They were likely tricked into giving their answers by users, just as provocative Twitter comments helped swindle Microsoft's Tay bot into making anti-Semitic and offensive comments such as "feminism is cancer."

But online access is a mounting concern.

Amazon.com (AMZN) , too, appears to be under pressure in China over its cloud computing services. One of Amazon's operators in China has told its customers to stop using software that would let someone get around China's controls.

Cloud computing is an increasingly thorny issue for the Chinese government, since it raises the potential for controversial content to be held outside China. In response, China is insisting that companies operating data services store the data within China's borders, ostensibly on public safety grounds. Banking data, for instance, could go missing.

But we know the real reason. It's so China can regulate what its citizens see, in a bid to control what they think, particularly on issues concerning the Communist Party and its unelected authority to govern.

The perils of operating in China are many, but top among them would be running afoul of the Communist Party. Bloomberg has given in by suppressing touchy news stories about Chinese officials, such as this non-working link to its own story once about the wealth of the family Chinese President Xi Jinping. Most companies capitulate. Chinese yuan are too good to give up.

Google, and now its parent Alphabet (GOOGL) , has been the only major company that springs to mind that has taken a stand against Chinese censorship. It pulled its search engine from China, redirecting traffic to its uncensored Hong Kong engine, in 2010 in a fight over China's censorship rules. The company is reportedly in talks to get access in China for some of its offerings, such as Google Scholar.

There are plenty of sites you can't access in China, including Facebook , Pinterest and Snapchat. But many would like to get in, given the chance. For instance, Facebook founder Mark Zuckerberg has been happy to chat with Chinese president Xi Jinping in Mandarin and post this Facebook photo of the two together.

You'd think online censorship is a battle destined to fail. Web access only grows with the production of every new digital site, app and device, while content proliferates faster exponentially.

But the Chinese government fights hard. And while they may know they're not getting the full truth, many of China's citizens believe a large amount of what they're told.

The Chinese government orchestrates 488 million fake social-media posts every year, according to a study led by Harvard University data scientist Gary King. In many cases, the government pays the equivalent of $0.08 for people who post comments cheer-leading for China, talking about the Communist Party's revolutionary history, or supporting the regime.

The first thing I do every time I visit mainland China is to log in to the hotel's WiFi and search for "Tiananmen Square." Here in Hong Kong, the Chinese government's 1989 massacre of students protesting in favor of democracy pops right up. It's appeared at a couple of Chinese hotels, too, presumably because the Chinese government hadn't yet paid them a digital visit.

Hong Kong and Macau are the only parts of China with their own rules on issues like censorship. Macau, relying on Beijing's approval of mainland travel visas to prop up its casino business, toes the party line. For now, I'm free to say what I want from my base in Hong Kong, but that freedom of expression is also disappearing, and fast.

The new administration of Chief Executive Carrie Lam, known for her stubborn streak and devotion to Beijing in equal parts, is under pressure to resurrect a highly unpopular "national education" curriculum, viewed by many teachers as patriotic airbrushing and brainwashing. It is also likely to attempt to introduce a "security" law, which by outlawing "sedition and subversion" will obliterate that theoretical freedom of speech.

It would certainly make it illegal for Hong Kong politicians to suggest that they support autonomy or independence for Hong Kong. To "challenge the power of the central government" or "endanger China's sovereignty," both terms that can and will be interpreted broadly, "crosses a red line."

That's what Chinese President Xi Jinping told Hong Kongers on his July 1 visit to "celebrate" the 20thanniversary of Hong Kong's reversion to China. Freedom of speech only allows you to say, it seems, what the Communists want you to say.

In China, it determines what you can read, see and hear online. Don't question authority, and don't get any upstart ideas.

That applies as much at the corporate level as the personal. Even providing the platform, the software, on which to express controversial sentiments crosses a very ill-defined line.

Will other companies take a stand like Google? Or will they all cave?

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Bitcoin Just Reached a New All-Time High – Futurism – Futurism

Posted: at 4:41 pm

In Brief Post fork, Bitcoin is surging up once more, reaching $3,000 for the first time since June, and surpassing $3,200 for the first time. This was accompanied by a peak in trade volume, and bitcoins market cap rests at around $54.13 billion at press time.

According to the CoinDesk Bitcoin Price Index (BPI), the price of bitcoin has shot up again, surpassing $3,200 for the first time. Market data indicates this latest surge started after 1:00 UTC on August 5, when the price of bitcoin surged past $2,900. By about 3:12 UTC, the price breached the $3,000 mark.

Although many predicted bitcoin would not fare well after the fork, these numbers seem to indicate otherwise. In fact, as Redditors have been discussing, Bitcoin is now worth more than $1 for each day it has existed. Senior Goldman Sachs technician Sheba Jafaris prediction about bitcoin starting a wave V during which its value could reach almost $3,700 is looking on point.Disclosure: Several members of the Futurism team, including the editors of this piece, are personal investors in cryptocurrency markets. Their personal investment perspectives have no impact on editorial content.

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China to Start Using Blockchain to Collect Taxes and Send Invoices – Futurism

Posted: at 4:41 pm

In Brief China has just announced that it will use blockchain technology for social taxation and issuing electronic invoices. This is just the latest example of the broad array of applications possible for the technology. Blockchain In China

The Chinese government listed blockchainin its Thirteenth Five-Year National Informatization Plan from 2015, and since that time the nation has been working diligently toward incorporate the technology into daily life. The techs inclusion in the plan signals the importance China has attached to it, and this was just confirmed by the governments announcement that it will utilize blockchain technology for social taxation and electronic invoice issuance matters.

This is a major development, and given that the Chinese economy is the worlds largest, with a 2016 GDP of over RMB 70 trillion (approximately U.S. $10.4 trillion), this should be an interesting test case for the implementation of blockchain technology. China has already launched a test of its own cryptocurrency based on the technology, so these initiatives should be able to build on each other.

Furthermore, we should also see implementation at the city level in China, as several local and provincial governments have recently promulgated pro-blockchain policies. In fact, asmart cities initiative has already enticed a Chinese automaker to integrate the tech into its business model. Additionally, blockchain-based industrial parks have gone up in Chengdu, Hangzhou, and other major cities, and agencies at different levels of government have created blockchain R&D teams.

This latest development in China is a good example of how blockchain technology can be used in a broad array of applications. Blockchain tech has been proposed for use in elections do to its potential for both transparency and security. Its these features that make it appealing for taxation as well.

Governments arent the only ones exploring the techs applications. Walmarthas started experimenting with a blockchain database that would protect consumers from contaminated food products as well as guard against product waste. Toyota is using blockchain to get its self-driving cars on the road faster, and the company plans to give customers access to their own data the same way.

Moving forward, we will see more and more innovative uses of blockchain technology as its potential is more fully realized. Transparency and security are both absolute essentials in a digital age, and China appears to be recognizing that need andputting this powerful techto use throughpolicy.

Disclosure: Several members of the Futurism team, including the editors of this piece, are personal investors in cryptocurrency markets. Their personal investment perspectives have no impact on editorial content.

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$90 million solar instrument panel created at CU Boulder headed to … – The Denver Post

Posted: at 2:48 am

A solar instrument panel designed and built by a University of Colorado Boulder lab and considered a key tool to help monitor the planets climate is at NASAs Kennedy Space Center in Florida awaiting a November launch.

The instrument suite is called the Total and Spectral Solar Irradiance Sensor, or TSIS-1. It will launch on a commercial SpaceX Falcon 9 rocket in a Dragon capsule for delivery to the International Space Station.

Once there, it will monitor the total amount of sunlight hitting Earth, as well as how the light is distributed among the ultraviolet, visible and infrared wavelengths.

We need to measure both because both affect Earths climate, said Dong Wu, the TSIS-1 project scientist at NASAs Goddard Space Flight Center in Maryland.

TSIS-1 was designed and built by CU Boulders Laboratory for Atmospheric and Space Physics, or LASP, for NASA Goddard. The contract value to LASP is $90 million and includes the instrument suite and an associated mission ground system.

CU Boulder professor Peter Pilewskie of LASP, lead mission scientist on the project, said TSIS will continue a 39-year record of measuring total solar radiation, the longest continuous climate record from space.

These measurements are vital for understanding the climate system because the sun is the source of virtually all of Earths energy, said Pilewski, also a faculty member in the department of atmospheric and oceanic sciences. How the atmosphere responds to subtle changes in the suns output helps us distinguish between natural and human influences on climate.

Overall satellite measurements of the sun from space have shown that changes in its radiation during periods of both high and low solar activity measure only about 0.1 percent. While scientists believe changes in solar output cannot explain Earths recent warming, a longer data set could reveal greater swings in solar radiation.

One of TSISs two instruments LASPs Spectral Irradiance Monitor will measure how light from the sun is distributed by wavelength and absorbed by different parts of the plants atmosphere and surface.

This is important because measurements of the suns UV radiation are critical to understanding the conditions of Earths protective ozone layer, Pilewski said.

The TSIS instrument suite will be operated remotely from the LASP Space Technology Building in the CU Research Park.

The project involved about 30 scientists and engineers at LASP during its peak, as well as 10 support personnel from Colorado and another 10 people elsewhere, TSIS-1 project manager Brian Boyle said. The mission, slated to run at least five years, also has involved about 15 to 20 CU Boulder undergraduate and graduate students.

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Skywatch: Perseids meteor shower will occur this week – Tulsa World

Posted: at 2:48 am

Sunday: The Big Dipper will be visible in the northwest tonight and is one of the most recognizable star patterns in the night sky. This group of stars is also useful in finding other stars. Imagine the handle of the Dipper as forming part of an arc. Move along the arc to the bright star Arcturus, which the International Space Station passed by a few days ago. Arcturus is one of the brightest stars visible in the sky. From Arcturus, continue along the arc to another bright star known as Spica. The mnemonic device arc to Arcturus and speed on to Spica will help in remembering these two bright stars names and locations.

Monday: The full moon occurs this afternoon at 1:10 p.m. The full moon of August is known as the Sturgeon Moon. This moon was named by fishing tribes because a large number of sturgeons were caught at this time. A partial eclipse of the moon occurs today as well, but will not be visible in the United States. Remember, though, in two weeks the total solar eclipse will occur.

Tuesday: Tonight the planet Jupiter is about 20 degrees above the south-southwest horizon. A telescope aimed at the giant will reveal its four brightest moons all on the western side of the planet. The moons appear as bright stars near the planet and their motion can be apparent when they are observed for several hours.

Wednesday: There are a number of bright passes by International Space Station the rest of the week. Tonight the space station first appears 10 degrees above the northwest horizon at 10:12 p.m. Three minutes later the space station reaches its highest point of 61 degrees above the northern horizon. The ISS will be located halfway between the North Star and the bright star Vega. Also at this point the space station slips into the Earths shadow and disappears.

Thursday: The International Space Station takes a bright northerly track through the sky tonight. The spacecraft starts off in the north-northeast at 9:20 p.m. By 9:23 p.m. the space station has reached its maximum altitude of 35 degrees above the northeast horizon. A minute and a half later the ISS disappears as it enters the shadow of the earth 20 degrees above the eastern horizon.

Friday: The Perseids meteor shower peaks tomorrow afternoon, so the next two nights will be the time to look for them. but the moon will provide some interference. The radiant, or point in the sky where the meteors originate, is in the northern sky in the constellation of Perseus. At 4 a.m. the radiant is 50 degrees above the north-northeast horizon. Since the moon will be out for much of the night, rates of about 40 meteors per hour might be expected.

Saturday: The brightest International Space Station pass was held for the end of the week. Tonight the ISS begins its journey across the sky at 9:11 p.m. 10 degrees above the northwest horizon. The space station then passes through the handle of the Big Dipper and by 9:14 p.m. is directly overhead. As the spacecraft continues across the sky, appearing brighter than any other object visible at this time, it eventually slips into the Earths shadow 20 degrees above the southeast horizon.

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Israeli team finds biological basis for rare neurological kids’ disease … – The Jerusalem Post

Posted: at 2:47 am

The secret to healing what ails you lies within your own DNA. (photo credit:DREAMSTIME)

The biological basis of a severe and mysterious neurological disorder in children that is caused by a single error in one gene has been described for the first time by a multinational team led by researchers from Jerusalem.

Just published in the American Journal of Human Genetics, the study was headed by Prof. Orly Elpeleg of the pediatrics department at the Hebrew University of Jerusalems Faculty of Medicine and director of the genetics department at Hadassah- University Medical Center.

Elpeleg credits the discovery to deep sequencing technology that Hadassah and Hebrew U. were among the first to introduce into clinical practice in Israel and in the world.

The team found that affected childrens cells are flooded with ribosomal RNA and are poisoned by it. It was the first time an excess of ribosomal RNA has been linked to a disease in human regression and neurodegeneration.

The disease does not yet have a name.

At first, affected children lead normal lives and seem identical to their age-matched peers.

However, beginning at age three to six, they show neurological deterioration gradually losing motor, cognitive and speech functions. Although the condition progresses slowly, most patients are completely dependent sometime between 15 to 20 years of age.

Working with colleagues from the Pennsylvania State University College of Medicine and a multinational research team, the Israeli-led team have now identified and studied seven children from Canada, France, Israel, Russia and the US who suffer from the disorder.

The researchers found in all patients the same spontaneously occurring, non-inherited genetic change in a gene, named UBTF, responsible for ribosomal RNA formation.

It is because of this small change that patients cells are flooded with ribosomal RNA.

Ribosomes are responsible for the translation and production of cell proteins. They are made up of ribosomal proteins and of ribosomal RNA in a precise ratio.

The researchers found an identical error in the same gene in all the patients tested, representing a difference of one letter among the roughly three billion that make up human DNA.

By finding the identical change in children with the identical clinical disease, the researchers determined the altered gene was indeed the cause of the disease.

Elpeleg initially encountered the disease in a young girl who came to Hadassah.

Five years ago, I saw a patient who was healthy until the age of three and then experienced a disturbance in her walking and motor function, speech and cognition. Around that time, we had introduced the deep-sequencing technology for clinical use at Hadassah, which enabled us to read all the coding genetic material of a person within a couple of days, in order to identify genetic defects.

Since 2010, Hadassah has assembled the largest genetic mapping database in Israel with around 2,400 patients.

Searching for similar genetic defects in this database, we found a nine-year-old boy who had been treated at Hadassah and now lives in Russia. The boy had been healthy until the age of five and then displayed neurological deterioration just like the girl I had diagnosed, said Elpeleg.

Dr. Simon Edvardson, a pediatric neurologist at Hadassah, flew to Russia, examined the boy, took genetic samples from him and his parents and confirmed that his illness was identical to that of the Israeli girl. We then knew we had identified a new disease that was not recognized in the medical literature, said Elpeleg.

Comparing their data in a program called Gene Matcher, the researchers found several more children around the world who shared an identical genetic defect and the same course of disease.

To understand the mechanism of the newly identified disease, the researchers collaborated with Dr. George-Lucian Moldovan at Pennsylvania State University College of Medicine who confirmed the disease mechanism in the childrens cells, there is an excess RNA of the ribosome, which probably causes brain cells to be flooded and poisoned.

While there is currently no cure for genetic diseases of this kind, the identification of the exact mutation may allow for the planning of therapies designed to silence the mutant gene.

Science may not be able to repair the gene, but now that our findings are published, it may be possible to make early identification of the disease and in the future find ways to prevent such a serious deterioration, Elpeleg said.

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Israeli team finds biological basis for rare neurological kids' disease ... - The Jerusalem Post

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