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Category Archives: Transhuman News

Genetic Variance is Key to Individual Immune Response – Genetic Engineering & Biotechnology News

Posted: August 18, 2017 at 4:50 am

Ever wonder why your friend, co-worker, or partner doesnt get as sick as you, even though they caught the same bug you did? Maybe they made some Faustian bargain that affords them greater protection to infections, or perhaps they are part of some top-secret government experiment that injects them with an array of antigens isolated from an alien race living in Area 51. While both theories are potential explanations, it seems likely that differences in response to infection lie in something a bit more scientificlike genetics. Now, a collaborative team of investigators from the University of Bonn, Germany, and the New York Genome Center has just published findings that map several genetic variants that affect how much gene expression changes in response to an immune stimulus.

Results from the new studypublished in Nature Communications in an article entitled Genetic Regulatory Effects Modified by Immune Activation Contribute to Autoimmune Disease Associationsoffer novel insights into the genetic contribution to varying immune responses among individuals and its consequences on immune-mediated diseases.

Our defense mechanisms against microbial pathogens rely on white blood cells that are specialized to detect infection," explained co-senior study investigator Veit Hornung, Ph.D., chair of immunobiochemistry at the Ludwig-Maxmilians-Universitt in Munich. Upon encounter of microbes, these cells trigger cellular defense programs via activating and repressing the expression of hundreds of genes.

We wanted to understand how genetic differences between individuals affect this cellular response to infection," added co-senior study investigator Johannes Schumacher, Ph.D., a research scientist at the Institute of Human Genetics within the University of Bonn.

The human immune system plays a central role in autoimmune and inflammatory diseases, cancer, metabolism, and aging. The researchers discovered hundreds of genes where the response to immune stimulus depended on the genetic variants carried by the individual.

"These genes include many of the well-known genes of the human immune system, demonstrating that genetic variation has an important role in how the human immune system works," noted lead study investigator Sarah Kim-Hellmuth, Ph.D., a postdoctoral researcher at the New York Genome Center. "While earlier studies have mapped some of these effects, this study is particularly comprehensive, with three stimuli and two-time points analyzed."

In the current study, the research team captured genetic variants whose effects on gene regulation were different depending on the different infectious state of the cells. These included four associations to diseases such as cholesterol level and celiac disease. Moreover, the researchers discovered a trend of genetic risk for autoimmune diseases such as lupus and celiac disease to be enriched for gene regulatory effects modified by the immune state.

"Here, we isolate monocytes from 134 genotyped individuals, stimulate these cells with three defined microbe-associated molecular patterns (LPS, MDP, and 5-ppp-dsRNA) [lipopolysaccharide, muramyl dipeptide, and 5' triphosphate double-stranded RNA], and profile the transcriptomes at three-time points, the authors wrote. Mapping expression quantitative trait loci (eQTL), we identify 417 response eQTLs (reQTLs) with varying effects between conditions. We characterize the dynamics of genetic regulation on early and late immune response and observe an enrichment of reQTLs in distal cis-regulatory elements. In addition, reQTLs are enriched for recent positive selection with an evolutionary trend towards enhanced immune response. Finally, we uncover reQTL effects in multiple GWAS [genome-wide association study] loci and showed a stronger enrichment for response than constant eQTLs in GWAS signals of several autoimmune diseases.

Co-senior author Tuuli Lappalainen, Ph.D., assistant professor at Columbia University and core member of the New York Genome Center added that this data supports a paradigm where genetic disease risk is sometimes driven not by genetic variants causing constant cellular dysregulation, but by causing a failure to respond properly to environmental conditions such as infection."

Using the collected monocyte samples, the researchers treated the cells with three components that mimic infection with bacteria or a virus. They then analyzed how cells from different individuals respond to infection by measuring gene expression both during the early and late immune response. Integrating the gene expression profiles with genome-wide genetic data of each individual, they were able to map how genetic variants affect gene expression, and how this genetic effect changes with the immune stimulus.

Findings from this new study provide a highly robust and comprehensive dataset of innate immune responses and show wide variation among individuals exposed to diverse pathogens over multiple time points. The investigators identified population differences in immune response and demonstrated that immune response modifies genetic associations to disease. The research sheds light on the genomic elements underlying response to environmental stimuli and the dynamics and evolution of immune response.

"It's been known for a long time that most diseases have both genetic and environmental risk factors, concluded Dr. Lappalainen. But it's actually more complicated than that because genes and environment interact. As demonstrated in our study, a genetic risk factor may manifest only in certain environments. We are still in early stages of understanding the interplay of genetics and environment, but our results indicate that this is a key component of human biology and disease. The molecular approach that we took in our study can be a particularly powerful way for researchers to delve deeper into this question."

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Genetic Variance is Key to Individual Immune Response - Genetic Engineering & Biotechnology News

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White supremacists take DNA tests, find they’re not so white – CNET

Posted: at 4:50 am

Technically Incorrect offers a slightly twisted take on the tech that's taken over our lives.

What is white? And why is it supreme?

Which of us is pure?

Pure of spirit, pure of thought and, well, pure of blood.

Surely not many.

Yet in our fractured times, some want to believe that they are superior because of their pure whiteness.

A few of these sorts featured in the Charlottesville, Virginia, marches last weekend.

It seems, though, that some white supremacists try to use science to confirm their superiority. So they turn to services such as Ancestry.com and 23andMe in order to take DNA tests.

A new study by UCLA sociologists Aaron Panofsky and Joan Donovan suggests that these results sometimes disturb the purists.

The researchers studied 3,070 postings on white nationalist forum Stormfront over a 10-year period. There, some who are shocked that they might have, say, African heritage share their results in an attempt to dispute the findings and confirm their purity.

The researchers say they saw evidence of posters using "the particular relationships made visible by GATs (genetic ancestry testing) to re-imagine the collective boundaries and constitution of white nationalism."

The pain of not being defined as white is so great that they desperate try to redefine what white really is.

Some of those upset with their results then insist that you should take what your grandparents told you more seriously than the science. There are claims that because testing companies are "quite liberal," they deliberately sprinkle in some non-white DNA into results to suit their political beliefs.

Others prefer to believe their mirrors. "I wouldn't worry about it," said one Stormfront poster cited in the study. "When you look in the mirror, do you see a jew? If not, you're good."

And then there are those who just prefer to think of their results as being subject to statistical error.

Do any of these people complain to the testing companies?

A 23andMe spokesman told me diplomatically: "With over 2 million customers, we do get the occasional complaint." He said the company's customer service then tries to help complainers understand how the results came about.

"The average 23andMe customer has DNA from at least five different regions from around the world," he told me.

As for Ancestry.com, its spokesman said he had no knowledge of specific white supremacist complaints. Instead, he said, the largest number of complaints come from people convinced they have some Native American in their blood.

Even though the results given are estimates of ethnicity, the spokesman said: "We are very confident in our science. This is well-established, recognized science that has been published in scientific journals."

Ancestry.com currently traces ethnicity across 26 different regions, as well as 334 genetic communities, which are more granular historical groups of people like "Ulster Irish," "Early Settlers of New York" or "Early Settlers of New Mexico."

"People looking to use our services to prove they are ethnically 'pure' are going to be deeply disappointed. We encourage them to take their business elsewhere," said the Ancestry.com spokesman.

Still, one can imagine the disappointment in discovering you're not who you really think you are.

Perhaps the most tragic postings featured in the research concern those who try to celebrate that they are, as in one case, a mere 61 percent European.

A Stormfront poster replied to one of these optimists: "I've prepared you a drink. It's 61percent pure water. The rest is potassium cyanide. I assume you have no objections to drinking it. (You might need to stir it first since anyone can see at a glance that it isn't pure water.) Cyanide isn't water, and YOU are not White."

I wonder in how many cases white supremacists actually reconsider not only themselves, but the world view they espouse.

Or would that be too painful?

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White supremacists take DNA tests, find they're not so white - CNET

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Kirk Frost Finally Takes DNA Test After Months Of Dodging Jasmine Washington: Why He Finally Agreed – Hollywood Life

Posted: at 4:50 am

At last! Kirk Frost decided not to share his DNA test results on L&HH: Atlanta, but it looks like the truth may be revealed soon enough. Weve EXCLUSIVELY learned why Kirk finally agreed to take the paternity test!

Jasmine Washington, 27, shocked the world when she claimed that Kirk Frost, 48, fathered her child while he was still married. Even though he decided not to reveal his DNA test results on the Love & Hip Hop: Atlantareunion specials, the truth may come to light soon enough! Kirk continued to dodge the DNA test and refused to take it for as long as he could but it was court ordered, a source close to the case tells HollywoodLife.com EXCLUSIVELY. So Jasmines attorney filed a warrant application for Kirk to force him to take the court-ordered DNA test or go to jail. This scared Kirk enough to finally succumb to taking the test this week and the results of which, at last, are finally really truly on the way.

Months after arguing back and forth, Jasmine and Kirks paternity case was reportedly thrown out Aug. 16, after they both didnt show up to court. But it seems obvious to all those involved that Kirk is the father and this test will prove that, finally, once and for all, our insider revealed. Fans are wildly speculating what the reason behind this shocking development is. Did they possibly want to settle out of court? Jasmine sent fans into a frenzy during season six when she claimed that Kirk cheated on his loving wife Rasheeda Frostby hooking up with her. There [still] has not been a settlement. I can tell you that, Tony Mathis, Jasmines attorney tells us EXCLUSIVELY.

As we previously reported, Jasmine has no idea what she is going to do if Kirk is not the father of her baby, a source close to the reality star shares with HollywoodLife.com EXCLUSIVELY. She is trying to be patient and has waited a long time for the results of the DNA test to determine Kirks paternity status. She has no plan B and has no idea what she would do if Kirk is miraculously not named the father. Rasheeda previously revealed that if Kirk is the father, she would let his child get to know their kids as well.

HollywoodLifers, do you think the test results will ever be revealed? Tell us, below!

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Natalee Holloway’s Dad Having Human Remains Tested For DNA – HuffPost

Posted: at 4:49 am

The father of missing Alabama teen Natalee Holloway says he is awaiting the results of DNA testing on bones found in Aruba.

When we determined these remains were human, I was shocked, he said.

In a follow-up interview with HuffPost, Dave Holloway said the remains have been brought to the United States for DNA testing.

They are in the testing process, he said, adding that it could take several weeks to get results. Its a reputable lab and thats all I can tell you at this point.

Dave Holloway said the bones were found while he and private investigator T.J. Ward were chasing leads during the filming of a new TV series on the Oxygen network called, The Disappearance of Natalee Holloway.

Oxygen Media

Natalee Holloway, 18, from Mountain Brook, Alabama, disappeared on May 30, 2005, while on a trip to Aruba to celebrate her high school graduation. Her body has never been found.

Her classmates said they last saw her leaving an Oranjestad nightclub called Carlosn Charlies with Joran van der Sloot. At the time, he was a 17-year-old Dutch honors student living in Aruba.Police have repeatedly questioned him in connection with Natalee Holloways disappearance.

Van der Sloot is now behind bars in Peru, where he is serving a 28-year prison sentence for the 2010 murder of 21-year-old Peruvian business student Stephany Flores Ramrez.

Pilar Olivares / Reuters

According to Ward, an individual living in Aruba who claims to have helped van der Sloot dispose of Natalee Holloways body, provided the leads that led to the discovery of the bones.

We did an 18-month undercover investigation and a lot of the information we had was confirmed and its viable information that led us to where we are today, Ward told HuffPost.

Dave Holloway said he was not present when the bones were found and that theres a good chance [the bones] belong to someone else.

I dont want to get my hopes up this is Natalee, he said.

Oxygen Media

Wednesdays announcement comes just days before the Saturday premier of the Oxygen television series.

I cant get into any other details about it, said Dave Holloway. Youll see it on the show.

A spokesperson for the FBI told HuffPost they are looking into the claims. The U.S. Embassy in Caracas, Venezuela the U.S. office tasked with handling inquiries into the case Peru did not immediately return calls for comment from HuffPost.

David Lohr covers crime and missing persons. Tips? Feedback? Send anemailorfollow himon Twitter.

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Let’s enjoy the white supremacist freakout after DNA tests show they aren’t 100 percent white – Salon

Posted: at 4:49 am

Statnews a digital news site that focuses on medicine and science published an articleon Wednesday about white supremacists taking genetic tests to measure their whiteness. Manyusers on the white nationalist website Stormfrontposted their results from genetic ancestry company 23andmeandwere unpleasantly surprised to discover that they werent as white as they thought. Their reactions, as it turnsout, are a thing of schadenfreudic beauty.

Heres one personworried that he or she might be a bit Jewish:

I got 100 percent European on mine, and Im from the US and so is my whole family. The thing that DID blow my mind is that I got 18percent Ashkenazic on the standard view and almost 21percent on the speculative view. (They count Ashkenazic as European.) Looks like one of my grandfathers was secretly Jewish. He always said he was Russian. Welp, I guess he meant THAT kind of Russian. Its caused me to have to reassess my self-image a whole lot.

Stormfront Screenshot

In onethread titled My 23andme genetic ancestry results, a user found that he was 99.25 percent European, 0.02 percentAfrican and 0.73percent Asian. In another post, a white supremacist had to reevaluate his or her skin color, asking, Am I whitenow?

Stormfront Screenshot

Stormfront Screenshot

Such a small percentage of non-white really ticked off some of the white supremacists: EVERYsingle Americans results that I have seen ALWAYS have this 0.1% non-white garbage, and I literally mean every single one, and Ive viewed hundreds, wrote one user. This has led to a quest for what might be called alternative genetic facts, or as that user put it, results that are actually accurate and not rigged the way that 23andme is for the very reason and cause of trying to spread multiculturalism and make whites think that they are racially mixed.

While some on the sitewere fairly confident of 23andmes accuracy, others foundexcuses not to believe the results they found. Send your results to Dr. Mcdonald and he will give you your accurate results, saidone.

Stormfront Screenshot

Athread titled,Is 23andme legit? contained many users scapegoating one group for their ancestral flaws. One sustaining member of the racist site said that, of course, its all the Jews fault:

Theres Jews at the top, that said your results would likely show some non-White ancestry because of this. The Jews want us all to think weve got some non-White DNA so we are more likely to go along with their plan. They dont want us to resist genocide by assimilation.

Stormfront Screenshot

In the same thread, a member named headstar wrote:

The 23andMe forum is full of of retards:They think the Holohoax happened.It is full of both white and non-white hardcore nordicists.They think Spain is in Mexico and all those mixed race immigrants are Spanish. They stereotype Southern Europe and equate them to Arabs/Turks/non-Europeans.They refer to any white who isnt of 100% Anglo-Saxon/Northern European stock as a mutt.They like saying white in sarcastic quotation marks.

Some on the message boards like Segregationista did not get DNA testing, but they had advice for other white nationalists who found out they had Jewish ancestry:

Ive never had a DNA test, but I know where all my ancestors are from. I guess it could be amusing, though, having Jews tell me where I came from. I suppose I could use the the test results to become a citizen of Israel

Stormfront Screenshot

Looks like weve found the first victims of the white genocide.

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Let's enjoy the white supremacist freakout after DNA tests show they aren't 100 percent white - Salon

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Ask Amy: DNA testing reveals family secret – The Denver Post

Posted: at 4:49 am

Dear Amy: About a year ago, I used one of those genetic testing services. The website shows other users who share genetics with you, and allows everyone to contact each other.

Recently, I got a message from another user (a woman in her 60s in another state), that showed we were a very close genetic match.

She emailed me, saying she was looking for information on her father, whom she had never met. She said her mother had a very brief relationship with aU.S.marine during the Korean War. It turned out he had probably used a fake name. They had no photos, and they were never able to track him down. Her mother later moved to theU.S.

The woman, Janet, asked if it was possible if my grandfather (who is now dead) was her father. She knew very little except for what her mother (also now dead) had told her, including specific identifying physical characteristics. My grandfather was a Korean War veteran and had the exact characteristics she described (including a distinctive tattoo).

My grandfather wouldve been married to my grandmother (who is still alive) when Janet was been conceived. An uncle of mine was born a year before Janet.

I always saw my grandfather as a good, caring family man. I have not told anyone about this. I do not want to tarnish his memory, upset my grandmother, or change how my family views him, when hes not around to defend himself.

Janet would like to meet my aunts and uncles, but I have told her I am not comfortable giving her their contact information. She has recently started pleading with me, and I truly feel awful for not giving it to her.

What do I do here?

Torn

Dear Torn: One (perhaps unforeseen) aspect of using genetic testing is the way the results can open up confounding human dilemmas concerning long-buried family secrets. Recently, I was at a gathering where several people had used a genetic matching site and all of them noted shocking, unanticipated results, including being matched with (half) siblings they hadnt known about. And yet all reported that this ultimately was a positive experience.

In your case, Janet has already received useful genetic information. She now (quite understandably) wants more. You should at least answer any questions youre able to answer.

If you arent willing to even ask your aunts and uncles if they would be open to contact with her, then she will have to find another conduit to them.

It would be best if your family was open to the idea that people are complicated, and dont always do the right thing but this is the fullness of the human experience, and ultimately this is something to explore and embrace, rather than deny.

Dear Amy: My husband and I recently became friends with another couple. As a group, we get along famously.

However, lately I do not feel that my friend likes me. She makes remarks about how I dont exercise my dog, how I dont treat my husband right, how I treat my son, how they cant take me anywhere, and the list goes on.

I try not to trigger these comments and shrug them off, as they account for only a few unpleasant moments during several good hours spent together.

I like many other things about this person, but I do not like how she makes me feel when we are together. How do I let her know, without hurting her feelings, and how do I phrase asking her to stop throwing darts my way? Or am I just being too sensitive?

Had Enough

Dear Had Enough: I dont think its a lot to ask for someone to refrain from trashing you so no, you are not being too sensitive.

Tell your friend, I usually enjoy our time together. But you seem to find a lot wrong with me. Honestly, I dont like to be criticized, but especially in front of our husbands. Whats up with that?

She may say, as many do, Hey, I call em like I see em. Then you can tell her, Well, thats a trait that I dont appreciate. Its hurtful, and so I wish you would stop.

Dear Amy: Priority Parent described policing children on the playground. Is this priority parenting or helicopter parenting? Im quite sick of this sort of over-involvement.

Normal Parent

Dear Parent: This particular parent had a special-needs child. He is doing his job to pay close attention to potential dangers on the playground.

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DNA tests confirm Southern Bluefin Tuna on menu in mainland China – TRAFFIC – Wildlife Trade News

Posted: at 4:49 am

naturepl.com/David Fleetham/WWF

Beijing, China, 18th August 2017The Southern Bluefin Tuna market in China, a new study published today, has found Southern Bluefin Tuna is served in restaurants in mainland China, particularly Shanghai. This is a significant finding not only because of the threatened status of the tuna, but as it also provides insights into Chinas role as a non-member of the Commission for the Conservation of Southern Bluefin Tuna (CCSBT), the organization that sets annual fishing quotas for the tuna.

The majority of the fashionable Japanese-style sashimi restaurants sampled in Shanghai and Beijing were unable to provide details about which species of tuna they offered, but DNA testing by the Commonwealth Scientific and Industrial Research Organization (CSIRO) of 199 samples collected by TRAFFIC found 26 (13%) to contain Southern Bluefin Tuna (SBT): 96% of the positive samples were collected in Shanghai.

Download the full report The Southern Bluefin Tuna market in China

SBT is popularly consumed as sashimi in Japan, but over-fishing has led to significant stock declines where the species lives in the cool and temperate waters of the southern hemisphere. The tuna species, Thunnus maccoyii, has been classified by the International Union for Conservation of Nature (IUCN) Red List as Critically Endangered.

It is essential to understand who is catching and landing Southern Bluefin Tuna, who the consumers are and how much is being traded in order to conserve and manage surviving tuna stocks, said Joyce Wu, Senior Programme Officer with TRAFFIC in East Asia, and an author of the new study.

Management of SBT stocks, including setting annual quotas, is undertaken by the CCSBT, a regional fisheries management organization. Total allowable catches of SBT each year are set by the CCSBT for Members and Cooperating Non-Members to the Commission, but China has neither status and the discovery of SBT within the Chinese market clearly identifies the country as a SBT Market State.

Lo Sze Ping, CEO of WWF China said: The uncertainty around the quantities and whether the origin of the SBT available within the China market is from legal sources would lead us to encourage China and CCSBT, which is trying to manage this single stock of tuna, to consult with each other.

Customs data from mainland China show reported (re-)exports of around 50.6 t of frozen SBT between 2011 and 2013, more than the total imported frozen SBT (34.3 t) in the same period. Meanwhile, mainland China imported and retained more than 100 metric tonnes of SBT in 2014 and 2015, more than double in volume compared to 2013. This may indicate a rising demand for high-value sashimi tuna, and although it is possible the SBT in the Chinese market may all be derived from legitimate annual catch quota imports. When the reports findings were discussed by CCSBT members in 2016, they concluded there were indications that a high proportion of SBT in China was from illicit sources.

These suspicions were further supported after a Chinese vessel found fishing in waters between Fiji and New Zealand in 2016 was found to be unlicensed and DNA testing proved it had misreported its catch of 100 tonnes of SBT as the less valuable Bigeye Tuna. The Chinese authorities reacted swiftly and deregistered the company, fined it approximately USD600,000 and banned it from working in international waters.

The report warns that incomplete SBT trade data may be concealing other infractions. Japan, for example, does not record information on shipments worth less than JPY200,000 (USD1,800) in value. The report recommends that Japan document all trade in SBT including confirmation of sashimi tuna trade volumes with mainland China and Hong Kong.

Marked and labelled Southern Bluefin Tunas Thunnus maccoyii. Tokyo fishmarket Japan Michael Sutton /WWF

Increasing the consistency in data recording by Japan and other fishing entities will help clarify the dynamics of the Southern Bluefin Tuna trade and identify whether any illicit trade is taking place that is not being reported or is beyond quotas, said Wu.

Improved data collection would also improve the traceability of SBT along the trade chain by, for example, following World Customs Organization (WCO) recommendations on the use of Harmonized System (HS) Customs codes.

The lack of basic and accurate information about the quantity and origin of Southern Bluefin Tuna in trade undermines CCSBTs management efforts and highlights the need for the introduction of clear traceability systems to track precisely what was traded, where it went and where it ended up, said Wu. Whether it be Flag, Port or Market States, all need to take responsibility for the impact on wild populations of tuna, particularly for species such as SBT which has been reduced to such a low level and are under management to rebuild the stock to a biologically safe level.

Trade chain traceability including tuna offered for sale in restaurants as well as e-commerce platforms is absolutely vital given the potential size of the Chinese market and the impact it could have on the remaining Southern Bluefin Tuna stocks.

WWF will continue to assist Chinese corporate partners to reduce environmental risks involved in their e-commerce platforms and logistic systems, helping them to categorize their traded products on the platforms according to environmental impacts, and ensuring stable growth in profit, said Lo Sze Ping.

The Southern Bluefin Tuna market in China report was made possible by funding from the Commission for the Conservation of Southern Bluefin Tuna.

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Supremacists may be ‘fine’ folks, but first give them DNA tests – Lexington Herald Leader

Posted: at 4:49 am


Lexington Herald Leader
Supremacists may be 'fine' folks, but first give them DNA tests
Lexington Herald Leader
That was candidate Donald Trump, who condemns violence on many sides, telling his supporters at a rally last year how to handle a protester who took exception to all the love that was being shared that evening. You remember, the love for immigrants, ...

and more »

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Eczema cure? Doing THIS at the gym could treat the debilitating skin condition – Express.co.uk

Posted: at 4:48 am

GETTY

It may seem like an irritating side-effect of hot weather, but sweating is essential for helping your body regulate its temperature, preventing you from overheating.

But its benefits may actually extend further for our health.

Research found that it can help clear up your skin naturally.

A 2005 study published in the Journal of Immunology revealed that atopic dermatitis - a type of eczema - may be triggered because sufferers are lacking dermcidin, an antimicrobial peptide, in their sweat.

GETTY

Research has found that sweating helps excrete arsenic, cadmium, lead, and mercury, as well as reduce risk of kidney stones and treat eczema.

Additionally people who sweat more often due to exercise have a lower risk of kidney stones.

This is thought to be because salt is sweated out instead of the kidneys having to process it, potentially risking stone formation.

It can also help you get rid of toxins.

Research published in the Journal of Environmental and Public Health found that it helps excrete arsenic, cadmium, lead, and mercury.

Getty

1 of 9

Kidney stone risk factors

GETTY

A study released last week by the University of Missouri found that high levels of cadmium raise risk of endometrial cancer in women.

Exercise is an easy way to induce sweat, but can also be triggered in environments such as a sauna.

While some sweating is clearly beneficial, perspiring excessively - known as hyperhidrosis - may be a problem.

As well as being embarrassing it can interfere with daily activities.

GETTY

It is an issue that is surprisingly common in the UK.

Indeed, a survey by Odaban found that 54.7 per cent of Britons suffer from heavy sweating.

Im horribly conscious that I need to present a cool, calm and professional voice of reason in the business meeting environment, so I often take a change of clothes, especially shirts, which Ill put on just before I arrive at my destination, said Charles, 55, a finance director who suffers from excessive facial and all-over body sweating.

I reckon its cost me thousands just in replacement or top-up clothes alone.

Then, of course, I have to perform in the meeting. It sounds trivial, but its dominated my working life for as long as I can remember. Not in a good way at all.

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Here’s how medical marijuana can help with psoriasis – NY Daily … – New York Daily News

Posted: at 4:48 am

THE FRESH TOAST

Monday, August 14, 2017, 11:50 AM

Psoriasis is an autoimmune disease that causes itchy scaling of the skin. It typically affects the elbows, knees, and scalp, but any skin-covered place will do.

About7.5 million Americanshave psoriasis. For most, it will manifest only in patches. But if it extends over more than five percent of your surface area, then you are among the one-in-five who have a severe case.

RELATED STORY: Little-known health effects of medical marijuana

There are many faces of psoriasis. Lesions may be slivery or fiery red, pussy or merely bloody, small or expansive in scale. Fingernails may or may not discolor, crumble, and detach. As many as a third of people with this condition will receive the bonus gift of psoriatic arthritis.

Genetically inherited, psoriasis is yet another trauma we receive from our parents, but its appearance tends to be triggered by physical or emotional stress.

During an outburst, T cells that normally protect us from bacterial incursions mistakenly begin to attack our own skin cells. As white blood cells rush into the fray, the blood vessels dilate, causing inflammation. The body then goes into overdrive to replace the dead and dying skin. New cells push up, as much as ten times faster than normal, accumulating on the surface in thick mounds of dead skin and white corpuscles, intertwined like the corpses of ice-zombies and men of the Nights Watch strewn across the plains of the frozen North.

Because of cannabiss well known anti-inflammatory andimmunosuppressiveeffects, its a natch that it ought to have some ameliorating effect onthe heartbreak of psoriasis. But the medical evidence is thin.

RELATED STORY: Why wont my doctor prescribe medical marijuana for me?

One of the most intriguing findings comes from a2007 studythat tested the effects of five different cannabinoids (including everybodys favorites THC and CBD) on skin cells that were induced to hyper-productivity in vitro. All five cannabinoids inhibited proliferation. (Thats good news!) But heres something that flouted all expectation: Blocking both the CB1 and CB2 cannabinoid receptors had no effect on the outcome. In other words, the cannabinoids were operating by some means other than the two scientifically recognized pathways.

What that means is, however, still unknown.

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