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Category Archives: Transhuman News

Co-creator of CRISPR lectures about future applications of genome editing technology – Daily Bruin

Posted: November 20, 2019 at 5:49 am

A University of California professor and co-originator of genome editing technology Clustered Regularly Interspaced Short Palindromic Repeats said researchers plan to expand the technology in order to increase human applications at a campus lecture series Thursday.

Jennifer Doudna, a UC Berkeley biochemistry professor, engaged students and the greater UCLA science community during the quarterly Donald J. Cram Distinguished Lecture series.

The Cram lecture series, a quarterly departmental event, invites prominent academics in the field of chemistry to speak about their research. The series is dedicated to Donald J. Cram, who was a Nobel laureate and a chemistry professor at UCLA for over 50 years.

This fall, the series was hosted by UCLA chemistry professor and Cram Chair Patrick Harran.

Scientists use CRISPR technology, formally known as CRISPR-Cas9, to modify DNA sequences and gene functions. Cas9 is a protein that can cut the strands of DNA-like molecular scissors.

CRISPR is studied and used by students, scientists and researchers to advance progress in the field of gene editing, in medicine and the life sciences.

The UC holds the largest CRISPR patent portfolio in the nation with 16 total patents, according to a UC Berkeley press release.

The United States Patent and Trademark Office granted the UC, along with the University of Vienna and Emmanuelle Charpentier, the director of the Max Planck Institute for Infection Biology, its 16th patent in October.

Doudnas involvement in CRISPR technology began around 2005, when a professor at UC Berkeley, Jill Banfield, invited Doudna to help her with research into the mechanism. From there, Doudna teamed up with Charpentier, who was working with a CRISPR system and its associated protein, Cas9, in 2011.

Doudna is one of the creators of the CRISPR utility for the permanent excision of harmful genes. Doudna said that she developed the idea for the CRISPR technology in 2011 in collaboration with Charpentier.

During the lecture, Doudna detailed how scientists regulate CRISPR enzymes to modify DNA.

CRISPR is a portion of the bacterial genomic sequence that acts as an adaptive immune system, Doudna said.

Bacteria encode the CRISPR system through viral infections, which allows its genome to recognize foreign DNA insertions. These DNA sequences incorporate themselves into the bacterial genome at the CRISPR locus, a genetic database of past infections.

Doudna said this locus was of unique interest to her.

Those sequences, called CRISPR, are transcribed in RNA molecules that provide the zip codes for Cas proteins, allowing them to recognize foreign DNA and cut it up, Doudna said.

Doudna and Charpentier, with the assistance of their team, were able to realize that CRISPR RNA is a 20-nucleotide sequence, which interacts with DNA in a complementary fashion.

This complementarity allows the protein to form a double-stranded break in DNA, necessitating a second RNA tracrRNA to form this functional unit, Doudna said.

And it was (biochemist) Martin Jinek in our lab who figured out that you could combine these two RNAs into a single guide RNA, Doudna said.

From this experiment, Jinek found that single guide RNAs were used by Cas9 to excise DNA at specific sites in a plasmid, a circular piece of bacterial DNA. The revelation from this was that, upon excision, DNA would repair itself in animals and plants, Doudna said.

Doudna said at the end of her talk that the system is becoming increasingly important in the field of medicine, and is currently being used at UCLA, by Donald Kohn, a professor of microbiology, immunology and molecular genetics.

Were within about five years, maybe less, from being able to make, essentially, any change to any genome in any type of cell, Doudna said.

Doudna stressed that this ability to make changes in the genome comes with bioethical responsibility for genome editing in humans.

Fourth-year biochemistry student Jeremy Shek, who attended the event, said although he had done a project that was an offshoot of CRISPR, he had not heard of the progress Doudna discussed.

It is important to be informed on advancements and progress in the field, he added.

Fourth-year bioengineering student Timothy Yu said he came to the lecture to see Doudna in person and get a more solid grasp on the methodology of CRISPR.

Lexi Omholt, a fourth-year microbiology, immunology and molecular genetics student, said that she came to the talk to understand the basis of CRISPR technology.

Jennifer Doudna was one of the reasons I chose my major, Omholt said. At that time, CRISPR came into popular knowledge, and the knockout tool was just coming into use. I am involved in a cancer lab, the Soragni Lab, that uses CRISPR-Cas9 on a regular basis.

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Genome research gave life back to this West Vancouver cancer survivor – Vancouver Is Awesome

Posted: at 5:49 am

Candy Woodworth knows shes won the lottery.

In the past five years, shes seen a daughter get married and celebrate the births of two grandchildren.

But for a while, whether the West Vancouver grandmother would be around to mark those milestones was far from certain.

Six years ago, Woodworth was a busy 65-year-old, looking after her first grandchild while her daughters took care of the family business.

It was during a Pilates class when she was lying on her stomach that she first noticed something odd an uncomfortable feeling in her lower abdomen. Woodworth didnt think much of it, but when she felt it again at next weeks class, she made an appointment to see her doctor, who sent her for an ultrasound.

When she got back home, the phone was ringing before she even had her coat off, telling her to come to her doctors office right away.

There she got the news that she had ovarian cancer.

According to the BC Cancer Agency, over 300 women in B.C. will be diagnosed with ovarian cancer this year. Its not nearly as common as breast cancer women have about a one in 70 lifetime chance of getting ovarian cancer but the prognosis can be far more serious.

You just dont feel anything, said Woodworth. Thats the difficult thing with ovarian cancer.

Because there is no way to screen for ovarian cancer, and the disease is usually without symptoms until at an advanced stage, effective treatment is often a challenge.

We have treatments that are very likely to cause the cancer to regress and improve but theres a very high risk of recurrence, said Dr. Anna Tinker, a medical oncologist at BC Cancer who is one of the leading experts in gynecological cancers and who worked on Woodworths case.

Woodworth knew she was facing a serious diagnosis. So she did some research and was referred to the expert team that specializes in gynecological cancer at Vancouver General Hospital, headed by Dr. Dianne Miller.

Woodworth had surgery to remove the tumour from her abdomen, which was confirmed as a high-grade Stage 3 aggressive cancer.

But her journey was only just beginning.

For the next four and a half months, Woodworth had 18 rounds of chemotherapy. After my third week I literally crawled on my hands and knees into the chemo clinic, she said. I was literally throwing up as I was sitting in the chair.

She credits her support team of her husband and three daughters for getting her through it. And the chemotherapy worked at first.

But 18 months later, the cancer was back, with a tumour on her colon. She had another surgery.

Throughout the process, My attitude was always Lets get in there. Lets get the job done, she said.

When the tumour returned again in the same place, six months later, Woodworths doctors signed her up for an experimental research program, the Personalized Onco-Genomics program, run by a team of doctors and researchers at the BC Cancer Agency.

The program which is usually only open to patients after standard treatments have been tried takes a novel approach to cancer, looking for genetic mutations in a patients tumour for clues to whats causing the cancer to grow, and with that, a possible treatment.

In Woodworths case, the analysis showed her tumour had a signature similar to that seen when a BCRA gene mutation is present more usually associated with some types of breast cancer, said Tinker.

In early 2017 Woodworths results were matched with an experimental drug, Olaprib Lynparza.

In Woodworths case, the drug worked. Shes now been on it for two and a half years with no side effects and no recurrence in her cancer.

The 12 capsules she takes every day down from the number she started on have literally saved her life.

Im so grateful for every day, said Woodworth. I dont think the public realizes the scientists we have here in Vancouver.

Woodworth is among the more dramatic success stories to come out of the personalized genomic research project, falling into a small group of super responder patients.

Others include a Langley woman whose metastatic breast cancer was beaten back by a drug commonly used to treat diabetes, in addition to hormone treatment.

Another Metro Vancouver woman was saved when scientists discovered her advanced colon cancer had a protein that responded to blood pressure medication.

Since the program started in 2012, 1,136 patients, including 123 children, have been enrolled in the program.

Patients who take part need to understand the process is experimental, said Tinker. While helpful new information is gleaned in about 80 per cent of cases, the result is not always as dramatic as it was in Woodworths case and not all cancer patients are helped by the genome analysis.

In some patients, no helpful mutations are discovered that can be used as clues to treatment and in some cases, no drugs are a match.

Cancer patients start new treatments as a result of their genome results about 40 per cent of the time.

Ideally, patients who are matched with treatments can be enrolled in clinical trials that make expensive drugs available to them free of charge, said Tinker.

But thats not the always the case.

Woodworth knows shes lucky. I knew what I was up against, she said, but she remained stubbornly optimistic, describing herself as a glass half full kind of person.

These days, Woodworth who recently celebrated her 70th birthday takes delight in spending time with her grandkids.

I cant let a day go by without stopping by for a quick hug, she said. I dont stay around and clean my house. I get out there.

I dont take anything for granted. Thats the one thing you take away when you feel that mortality. You have to live every day the best that you can.

She hopes stories like hers will lead to money for research that will benefit other cancer patients.

The research at the Personalized Onco-Genome program is funded by approximately $22.7 million from the BC Cancer Foundation, largely raised through philanthropic donations, as well as by research grants, particularly through the Canada Foundation for Innovation.

Hopefully theyll find more [information on how cancers behave], and more people will survive, said Woodworth. Thats what I want for everyone. There is hope out there.

To find out how to donate to the research funded by the BC Cancer Foundation, including the Personalized Onco-Genomics program, click here.

To find out how to donate to the VGH/UBC Hospital Foundation, which benefits programs including the Ovcare research team examining gynecological cancers, click here

To view a CBC Nature of Things documentary on the Personalized Onco-Genomics program, which aired on the network in February 2017, click here

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Genome research gave life back to this West Vancouver cancer survivor - Vancouver Is Awesome

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Can Wheat Save the World? – Seed World

Posted: at 5:49 am

The wheat genome is complex can we figure it out in time to feed a growing world population?

A half-century ago, human beings took their first steps on the moon.

At first, its hard to imagine what that has to do with wheat, but for attendees of the first International Wheal Congress held in Saskatoon, Sask. earlier this year, the connection was apt.

I was 12 years old when that happened. Being a young child and seeing this on a small black-and-white TV was impressive, said Martin Kropff, director-general of the International Maize and Wheat Improvement Center (CIMMYT), who spoke on the opening day of the congress. Two men walked on the moon, but the fact is, the moon landing was the result of 500,000 people working together.

If we can put a man on the moon, we can solve 800 million people going to bed hungry every day. Wheat is a crucial part of that challenge.

Hosted by the University of Saskatchewan, the event brought together 900 researchers, agronomists and other scientists from 50 countries to talk about all things T. aestivum and T. turgidum.

The challenges ahead were the main focus as attendees zeroed in on the fact the world population is growing and more food is needed, specifically cereals which Kropff said will comprise a third of all calories and protein in the human diet in the future.

But for food prices to remain constant, annual yield gains in wheat would have to increase from 1.2 to 1.7%.

Thats no small challenge, Kropff added.

As noted by Tim Searchinger, senior fellow at the World Resources Institute (WRI), the reality is that agriculture occupies half the worlds vegetated land. That means for agriculture, the sheer task of feeding the world is a huge challenge for biodiversity and ecosystems especially since agriculture produces a quarter of the worlds greenhouse gas emissions.

Searchinger presented the WRIs recent report Creating a Sustainable Food Future, for which he was lead author. It is laid out as a five-course menu of solutions to ensure we can feed 10 billion people by 2050 without increasing emissions, fueling deforestation or exacerbating poverty.

Searchinger noted that between 2010 and 2050, food production must rise 56% in order to feed a growing population and reduce greenhouse gas emissions by two-thirds in the process.

Wheat can play a huge role in that, he said.

According to the report, to provide continuing yield gains, breeding will need to become more nuanced.

In the past, much yield gain in the major cereals like wheat resulted from shifting biomass from vegetative parts to seeds and shortening and stiffening of the stems so they could support more grain (resulting from higher fertilizer application) without falling over. These traits, which were largely responsible for the Green Revolution, are in some cases reaching their biological limits; crops can only grow so close to one another before they have no more space, and crops can only direct so much of their growth into edible portions before they will no longer stand upright, the reports authors state.

These limits, plus the need to boost crop yields even faster than in historical trends, present the crop breeding challenge.

As a result, four major related opportunities exist to increase crop yields through improved breeding: speeding up crop breeding cycles, marker-assisted and genomics-assisted breeding, improvement of orphan crops, and genetic modification. Searchinger emphasized that all these technologies play a role in creating new wheat for the world.

Thats why were here. The work youre doing is incredibly important, he said, and added that four recommendations to enable innovation in wheat include boosting breeding budgets, sharing genomic advances, leveraging new technologies, and increasing research on orphan crops.

According to the WRI report, the world probably devotes only around 1.41.7% of agricultural GDP to agricultural research and development, which is less than the rate of total research spending relative to the total global economy (2.1%).

Richard Gray, agricultural economist at the University of Saskatchewan, gave a talk titled Successes and Failures in International Wheat Royalty Collection. He said strengthening plant breeders rights through royalty collection is one way to ensure more stable funding for variety development, an initiative currently underway in Canada through an attempt to create a value creation system via either a trailing royalty or end-point royalty.

But there are challenges. According to Gray, UPOV 1991 Plant Breeders Rights alone has generally failed to create a viable private wheat breeding industry.

Producer support is an essential element of increased royalty collection and support has come where producers have some long-term ownership in wheat breeding programs, he said. Public and producer partnerships have played an important role in providing additional breeding resources while enhancing knowledge sharing.

This first IWC event was a merger of two previously parallel wheat symposia: the International Wheat Genetics Symposium that took place every five years and the International Wheat Conference held every four years. The two groups agreed to join their efforts to create IWC, said international organizing committee chair Hermann Brstmayr.

Wheat is in terms of acreage the largest crop on our globe. Wheat is needed for food, feed and materials in countless ways and wheat is a staple food for around two billion people, many of whom live in [developing] countries. Research has to play its role to deliver know-how, improved production tools and improved cultivars to make wheat production sustainable, he said.

Challenges are plentiful, as they have always been. Certainly, the more erratic weather extremes will be an important issue, cultivars need possibly more resilience and buffering capacity than before. Heat stress is very likely to increase. Also, resource efficiency particularly nutrient efficiency, such as nitrogen and phosphorous efficiency will gain more relevance. And wheat production is expanding into non-traditional areas, such as sub-Saharan Africa which means production systems need to be established for these regions.

Creating a new generation of wheat that is tolerant to heat stress, drought stress, excess moisture and a constantly-evolving army of pests will require ongoing efforts to collaborate globally which in many ways is already happening. University of Saskatchewan researchers led by wheat breeder Curtis Pozniak who helmed the events Canadian organizing committee played a key role in mapping the wheat genome as part of an international consortium.

The bread wheat genome is five times bigger than the human genome its a beast. The effort required to undertake cutting edge research like wheat genome sequencing is massive, said Richard Cuthbert, wheat breeder at the Agriculture and Agri-Food Canada Swift Current Research & Development Centre.

There are over 110,000 genes in bread wheat. Employing new technologies like gene editing will depend on how we can dissect complex traits to identify the genes that underlie them and how those genes work together. Were standing on the cliff of the next frontier in wheat. Now that we know what the genes are, we need to know how they work and interact with each other.

Also during the event, Genome Canada announced an investment of $11.2 million to go toward some exciting new research spearheaded by Pozniak and fellow wheat researcher Sylvie Cloutier of Agriculture and Agri-Food Canada.

Known as 4D Wheat: Diversity, Domestication, Discovery and Delivery, this research will use wild-wheat relatives and elite germplasm along with industry-leading genomic techniques to better understand wheats genetic potential. The study will also examine the economics and policies of using wild-wheat germplasm sources and germplasm from international sources.

Pozniak and Cloutiers work will be based out of the Crop Development Centre at the University of Saskatchewan and Agriculture and Agri-Food Canadas Ottawa Research & Development Centre, respectively.

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Does NASA’s Plan To Drop Planetary Protection For Parts Of Mars Risk Future Discoveries Of Extraterrestrial Life? – Science 2.0

Posted: November 18, 2019 at 6:45 pm

Right now all our missions to Mars are sterilized to protect it from any Earth life that could hitch a ride and confuse the searches. A report by the Planetary Protection Independent Review Board, published on October 17th 2019 recommends that NASA treats most of Mars similarly to the Moon for planetary protection. The report comes with a cover letter from NASA recommending to their planetary protection officer that they implement the proposal.

The suggestion is to reclassify large parts of Mars as Category II:

where there is only a remote chance that contamination carried by a spacecraft could jeopardize future exploration. In this case we define remote chance as the absence of niches (places where terrestrial microorganisms could proliferate) and/or a very low likelihood of transfer to those places.

COSPAR Workshop on Planetary Protection for Outer Planet Satellites and Small Solar System Bodies European Space Policy Institute (ESPI), 1517 April 2009

This would be fine if we had clear evidence that these regions are like the Moon. However, we don't. The report relies on an earlier 2014 report that is now out of date. Even when it was in process of publication, NASA and ESA took steps to get it independently reviewed. For some reason they cite the problematical 2014 report as their main source, and don't cite the critical 2015 review of it. This meme summarizes one of the several issues identified by the 2015 review:

Its important to get this right as there is no way to do a do over. It would be so sad to get to Mars, find life there, and then realize it was just life we brought ourselves. For many, the search for other lifeforms in our solar system is one of the major motivating reasons to explore Mars and other parts of our solar system with a potential for life.

This could also impact on the future commercial potential for Mars. If we find life based on a different biochemistry - this can be the basis of billion dollar industries in the future (as is already the case for enzymes from extremophiles). For details see Billions of dollars commercial potential of extraterrestrial biology. Perhaps biological prospecting for extraterrestrial life may be the most lucrative industry for Mars, if we do this right.

The results of this decision can impact on other countries too. The future scientific discoveries of ESA (Europe), ROSCOSMOS (Russia), JAXA (Japan), ISRO (India), CNSA (China) and any other nation with an interest in exploring Mars are all potentially impacted if we contaminate Mars irreversibly with Earth microbes.

There would seem to be a need here for a second more thorough review of this, just as NASA and ESA called for the 2015 review of the 2014 report that this report relies on. The Planetary Protection Independent Review Board is headed by a planetary geologist and it would seem to be more appropriate for an astrobiologist to head any review team.

The compilers of this new NASA report seem to have just made a mistake, as they show no awareness in the report that the 2015 review exists. As for private space, Elon Musk for instance thinks that if we find martian life, it is important not to extinguish it. However he thinks the reality is that it is likely it only exists deep below the surface, in habitats that would not be impacted significantly by what humans do on the surface (see 30 minutes into this video). As we will see there are many ideas proposed by astrobiologists for ways that martian life could potentially thrive in near surface conditions on Mars. These potential habitats may exist almost anywhere on Mars. The risk here is again of a mistake due to a space entrepreneur making an executive decision bsed on his own self confidence in his assessment of the situation on Mars.

It is easy to make a mistake here, because microhabitats for life and shallow subsurface habitats on Mars are likely to be undetectable from orbit. The harsh ultraviolet light would cause even surface lichens to huddle into partial shade in cracks and crevices. as they do in the high Antarctic mountains. Similarly it would be impossible to see life hidden beneath the surface of rocks, or beneath a mm or so of dust or deeper down in the top few centimeters of the Martian surface where, as we'll see, there are possibilities that conditions may be habitable for native as well as introduced Earth life.

Text on image: Lichens on Mars would huddle in partial shade protected from UV, like this lichen in high mountains in Antarctica. It could not be seen from orbit with 30 cm resolution.

Pleopsidium chlorophanum in Antarctica From DLR press release Surviving the conditions on Mars

Pleopsidium chlorophanum on granite, collected at an altitude of 1492 m above sea level at "Black Ridge" in North Victoria Land, Antarctica. This photograph shows its semi-endolithic growth in Antarctic conditions. You can see that it has fragmented the granite, and that pieces of the granite are partly covering it, possibly helping to protect from UV light. Photograph credit DLR

See Lichens, cyanobacteria and molds growing in humidity of simulated Martian atmosphere

This article will focus on the forwards direction, the risk of sending Earth microbes to Mars because the legal protection in that direction is very weak. But first lets look at the backwards direction.

Here is a video I made for this article (while working on the draft)

(click to watch on Youtube)

skip to What about the forwards direction?

In the backwards direction from Mars to Earth, we are strongly protected by many environmental laws and laws to protect human health that we didnt have at the time of Apollo. These laws dont rely on the Outer Space Treaty for their legal basis. How NASA categorizes Mars makes no difference to them. See the article by Margaret Race of the SETI institute.

NASA is going to send a sample caching rover to Mars in 2020 and they hope to send a second mission in the 2020s to return some of these samples back to Earth for analysis. They plan to return them unsterilized (a sterilized sample would not trigger environmental laws, but would be just like the sample returns from meteorites, comets, and the Moon).

I cant find any evidence that NASA have made a start on preparing the legislation. They havent left enough time to complete this process within their desired timescale, indeed, they probably should have started in 2010 or earlier if they want a sample return by 2030. There are papers about the engineering challenges of the sample return mission, but I can't find anything about the legal processes (if you know of anything do say in the comments).

Mars sample return concept - credit NASA. If NASA wants to return an unsterilized sample by 2030 they should have started the legal preparation for this about a decade ago at the latest. There is no sign they have even done any planning for the legal process yet.

Perhaps they expect it to be like Apollo 11 where they published the sample return precautions as an informal document on the day of the launch to the Moon and didnt go through any proper legal process? This would not be permitted today.

Mars could have extraterrestrial life there. Its not known to be sterile, and the dust can carry spores almost anywhere on the planet (more on this later).

As well see new discoveries have opened up the possibility of native microbial life on Mars hidden from our orbital telescopes just centimeters below the dust. This may be possible even in the exceedingly dry tropical areas where Curiosity is roving, especially if martian life has a biochemistry adapted to lower temperatures than Earth life.

Some Mars colonization enthusiasts and space engineers will tell you that any life we find on Mars will be from Earth, but they have not persuaded the astrobiologists of this. The designers of instruments to look for indigenous life there are careful not to make any assumptions about its biochemistry or whether it is related to Earth life.

We cant assume that any life in a sample returned from Mars is related to Earth life unless we have studied it already on Mars.

This life could also be hazardous to humans or our biosphere. To take a simple example, legionnaires disease is an infection of biofilms that can use the same methods to infect human lungs, seeing it as a warm biofilm - it is not adapted to humans. Some strains of it are now adapting to our environments, spread by humans infected by it, but the same could happen with Martian life that invades the lungs of an astronaut.

Astrobiologists say that though it is possible that Mars life could be mystified by an alien biochemistry, its also possible that it hasnt evolved any resistance to it, never having encountered it before. Joshua Lederberg put it like this:

"If Martian microorganisms ever make it here, will they be totally mystified and defeated by terrestrial metabolism, perhaps even before they challenge immune defenses? Or will they have a field day in light of our own total naivete in dealing with their aggressins?

from: "Paradoxes of the Host-Parasite Relationship"

Our lungs might offer no resistance, not even recognizing it as life as it munches away at them, and with a different biochemistry they would be likely to be naturally resistant to our antibiotics, which target particular processes of the pathogens. There would also be risk of larger scale environmental disruption, even if the martian microbes are harmless to humans. As the National Research Council put it in 2009:

The risks of environmental disruption resulting from the inadvertent contamination of Earth with putative martian microbes are still considered to be low. But since the risk cannot be demonstrated to be zero, due care and caution must be exercised in handling any martian materials returned to Earth

Assessment of Planetary Protection Requirements for Mars Sample Return Missions

These reports haven't gone into details of how the environment could be disrupted. To give some points to think over right away (I will come back to this later), would our ecosystems work the same way if eventually half the microbes in the soil, half the plankton in our oceans and half the microbes in the guts of animals and ourselves were mirror DNA, say, or PNA, or TNA, or had novel amino acids that Earth life doesn't use, or didn't use proteins, to give a few examples? How would Earth life respond to eating food with novel amino acids it never encountered before or with mirror versions of the amino acids it has already? What about accidental poisons, like the way that cyanobacteria can kill dogs and cows? This is especially so if the extraterrestrial microbes have a different biochemistry; they seem unlikely to be exact "drop in" replacements to terrestrial microbes. There would be changes in their composition and how they function. Microbes with their shorter lifespans would adapt relatively quickly, but higher lifeforms might find it a significant challenge.

The legislators would not ignore arguments such as these. There would be extensive public debate, and Earth would be protected.

Robert Zubrin (president of the Mars society) tells his space colonization enthusiasts that for Mars life to survive on Earth is like Sharks in the savannah (see What are Zubrin's arguments? in my Touch Mars? book). But they could also be like rabbits in Australia, and microbes aren't like sharks. Microbes able to thrive in extreme heat and extreme cold have been found in human belly buttons . You need to listen to astrobiologists, not space engineers, and for sure the legislators would listen to the astrobiologists. There is a reason why we protect Earth.

Yes, there are many possible scenarios according to which martian life would be harmless to us. It could be that what we find on Mars is an early form of life, so feeble it can't compete with Earth life, or it's adapted to very low temperatures and self destructs when it is warmed up. You can invent many scenarios where martian life is harmless to Earth, or even beneficial in some way. However, before an unsterilized sample return, we will need much more by way of evidence than optimistic projections and colourful analogies.

I used Margaret Races article in an attempt to work out a timeline here for return of an unsterilized sample with potential for microbial life of an unknown alien biochemistry. I assumed that there were no objections to delay the legal process. Even with that assumption, I dont see how it can be done before 2040, if you start the legal process today. This takes into account the likely time requirements for constructing the receiving facility, based on the previous sample return studies. NASA would not start the expensive build (half a billion dollars facility) until it knows what it is legally required to do.: Why we are unlikely to return an unsterilized sample before 2040. These laws don't depend on the wording of the Outer Space Treaty in any form, but are independent legislation to protect Earth.

For these reasons Im not concerned about the backwards direction as far as safety is concerned. I expect NASA to sterilize their sample if they do return those samples from Mars to Earth, or return them to somewhere isolated from contact with Earth, such as a satellite set up for telerobotic study of the sample above GEO. They can use either of those approaches within the Outer Space Treaty. If there is no possibility of an unsterilized sample contacting Earth's biosphere, or Earth entering into the chain of contact with an unsterilized sample, it wouldn't trigger this legislation to protect our Earth.

The main concern is for the forwards direction. There isnt any other legislation here to protect Martian life apart from the very weak Outer Space Treaty. It is based on a few phrases about harmful contamination.

If these proposals were adopted in the forwards direction, you could send what you like to these regions of Mars, tardigrades, and extremophile blue green algae that have already been tested in Mars simulation chambers. The only requirement would be to document what you do. Eventually you could send humans too, with this category II classification, though returning them would be another matter if they had made contact with extraterrestrial microbes on Mars.

The report is here together with a cover letter from NASA recommending to their planetary protection officer that they implement the proposal:

This new report has few cites. Incongruously, its lead author is a planetary geologist.

One of their main cites is a report from 2014 by Rummel et al which proposed the use of maps to divide Mars into special regions which need especially careful planetary protection measures such as was used for the Voyager landers in the 1970s, and others that have less stringent requirements such as is used for Curiosity:

This is the basis for their proposal that Mars could be subdivided into regions some reclassified as category II. Although they dont go into detail, presumably they would use a map like the one in the 2014 review, and classify all except the uncertain regions as category II:

Map from the 2014 report. Purple is low in elevation, and grey is higher elevation. Red and blue lines delineating regions are approximately 50 km in width

In the text overlay I summarize the objection to this map in the 2015 review "2014 map of uncertain regions of habitability. 2015 review says maps can only represent incomplete knowledge."

They dont mention the problems identified with the use of maps in the 2015 review.

Even before Rummel et als report was published, both NASA and ESA took steps to have it reviewed independently.

This 2015 review overturned several of the findings of the 2014 report, and in particular, it recommended against the use of maps [49] saying:

In general, the review committee contends that the use of maps to delineate regions with a lower or higher probability to host Special Regions is most useful if the maps are accompanied by cautionary remarks on their limitations. Maps [of] surface features can only represent the current (and incomplete) state of knowledge for a specific timeknowledge that will certainly be subject to change or be updated as new information is obtained.

5 Generalization of Special Regions and the Utility of Maps

This new NASA report doesnt mention the 2015 review. Its an extraordinary omission from a report that is recommending the use of maps for category II.

I dont know the reason for this omission. They certainly should have looked at this 2015 review, and not just at the original 2014 report, before making this recommendation to NASA to map out large parts of Mars as category II like the Moon.

The 2015 report used the example of Recurring Slope Lineae (RSLs) to explain why maps are not enough by themselves. These are seasonal streaks that form on sun facing Martian slopes. They appear in the Martian spring, grow and broaden through the summer and fade away in autumn.

These dark features are not themselves damp and may be dust flows. However, they are associated with hydrated salts and they may also be linked with salty water (brines) in some form. Sadly the HiRISE instrument can only observe them in the early afternoon locally, the driest time for the Martian surface, because of its high inclination sun synchronous orbit. This makes it especially hard to know if there are any brines moving down these slopes.

Warm Season Flows on Slope in Newton Crater (animated)

The first ones were found in higher latitudes, but many of these have now been found in the Martian tropics, especially on the slopes of the Valles Marineres. Their status is unknown, whether they could have habitats for Earth life or not. At present they are classified as

As such they meet the criteria for Uncertain Regions, to be treated as Special Regions. [a Special region is one that Earth microbes could potentially inhabit]

The 2015 review gives the example of the ExoMars Schiaparelli lander. All HiRISE images of the landing site were inspected for the possible presence of RSL's. [50]

As another example of this, 58 RSLs were found on Mount Sharp close to the Curiosity landing site.

Here are some of them:

Possible RSLs on mount Sharp not far from the Curiosity rover. These photos are taken at a similar time in the Martian year, they are less prominent in the earlier one in 09 March 2010 and more prominent with some new ones in the later image August 6 2012. Photo from supplementary information for Transient liquid water and water activity at Gale crater on Mars

Importantly, these were not discovered until after the Curiosity landing in 2012. See Slope activity in Gale crater, Mars (2015) and Nature article: Mars contamination fear could divert Curiosity rover

This shows that we mightnt always be able to rule out potential uncertain regions that could be habitats at a landing site. They may be discovered later, after the landing itself.

More RSLs have been found in the Mawrth Vallis region, one of the two final candidates for ExoMars landing site

These results denote the plausible presence of transient liquid brines close to the previously proposed landing ellipse of the ExoMars rover, rendering this site particularly relevant to the search of life. Further investigations of Mawrth Vallis carried out at higher spatial and temporal resolutions are needed to , to prevent probable biological contamination during rover operations,

Discovery of recurring slope lineae candidates in Mawrth Vallis, Mars

ExoMars isnt going to Mawrth Vallis, because they chose the other candidate Oxia Planum. I cant find anything about RSLs in Oxia Planum, but how confident can we be that this doesnt have RSLs or other potential habitats? Does non detection so far mean they arent there?

This new report also doesnt mention the long running and vigorous debate on the topic of whether we should relax sterilization requirements for spacecraft sent to Mars.

This debate started in two Nature articles in 2013 and has continued in Astrobiology journal through to 2019.

Both sides in this debate were in agreement that there is a significant possibility that Earth microbes can contaminate Mars.

Surely neither side in this debate would support classifying most of Mars as category II like the Moon.

Rather, the argument in Nature and Astrobiology journal is about whether we should reduce sterilization requirements for Mars in order to study these potential habitats quickly before human missions get there and make it impossible to study them in their pristine condition without Earth life.

The other side in this debate argue that we have a fair bit of time before humans get there, and that if we relax planetary protection we risk finding Earth microbes we brought there ourselves.

Those arguing for relaxing planetary protection are:

Against

This debate is not mentioned in this report.

Nor does it mention the many new potential surface or near surface habitats that have been proposed / indirectly detected / theorized since 2008. We have had more of these than there have been years since 2008.

The 2014 report briefly considers these. The 2015 review expands on this topic, and says that to identify such potential habitats requires a better understanding of the temperature and water activity of potential microenvironments on Mars, for instance in the interior of craters, or microenvironments underneath rocks. These may provide favourable conditions for establishing life on Mars even when the landscape-scale temperature and humidity conditions would not permit it. [46]

The 2014 report looked at distributions of ice and concluded that ice in the tropics is buried too deep to be a consideration[47]

However the 2014/5 review corrected this due to evidence of ice present at depths of less than one meter in pole-facing slopes[48]

Research since then still hasnt resolved these issues.

Even the 2014 report acknowledged limitations:

"Claims that reducing planetary protection requirements wouldn't be harmful, because Earth life can't grow on Mars, may be reassuring as opinion, but the facts are that we keep dis4g life growing in extreme conditions on Earth that resemble conditions on Mars. We also keep discovering conditions on Mars that are more similarthough perhaps only at microbial scalesto inhabited environments on Earth, which is where the concept of Special Regions initially came from."

"A New Analysis of Mars "Special Regions": Findings of the Second MEPAG Special Regions Science Analysis Group (SR-SAG2)" (PDF).

Id like to cover a couple of these potential habitats to motivate this, then Ill look at why it is so important to protect Mars from Earth life - is it really so important to make sure we dont mix Earth life with Mars life before we canstudy it?

Nilton Renno's droplets that form where salt touches ice - why did he call a droplet of salty water on Mars "a swimming pool for a bacteria"?

This is perhaps one of the most striking discoveries in recent years because of its implications for habitability of Mars. Nilton Renno found that liquid water can form very quickly on salt / ice interfaces. Within a few tens of minutes in Mars simulation

experiments.

Erik Fischer, doctoral student at University of Michigan, sets up a Mars Atmospheric Chamber on June 18, 2014. These experiments showed that tiny "swimming pools for bacteria" can form readily on Mars wherever there is ice and salt in contact.

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Does NASA's Plan To Drop Planetary Protection For Parts Of Mars Risk Future Discoveries Of Extraterrestrial Life? - Science 2.0

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NASA’s next mission to look for ancient alien signatures on Mars, Jim Green’s prediction turning true? – International Business Times, India Edition

Posted: at 6:45 pm

WATCH | ISRO successfully launches PSLV-C46 carrying 'all-weather' spy satellite to combat terrorism

It was around a few weeks that Dr Jim Green, a chief NASA scientist, predicted that alien life on Mars will be discovered on Mars within 2021. After making the prediction, Green also added that humans are not prepared to accept the reality behind extraterrestrial existence. Now, NASA has revealed that its upcoming 2020 Mars Rover mission will explore the Jezero Crater to look for ancient signs of life on the Red Planet.

Mars global mosaic shot by the MCCISRO

It should be noted that the Jezero Crater which is almost 28-miles wide has sufficient deposits of minerals that are good at preserving microfossils here on Earth. Scientists believe that the Jezero Crater had apparently hosted a lake in the ancient past, and if alien lifemight have thrived there, this new mission could help to find ample micro-fossilized evidence. NASA scientists also revealed that exploring the Jezero Crater will begin in February 2021.

Marginal carbonates

"The possibility that the 'marginal carbonates' formed in the lake environment was one of the most exciting features that led us to our Jezero landing site. Carbonate chemistry on an ancient lakeshore is a fantastic recipe for preserving records of ancient life and climate. We're eager to get to the surface and discover how these carbonates formed," said Ken Williford, Mars 2020 Deputy Project Scientist of NASA's Jet Propulsion Laboratory in Pasadena, California, in a recent statement.

Side-by-side movies shows how dust has enveloped the Red Planet, courtesy of the Mars Color Imager (MARCI) wide-angle camera onboard NASA's Mars Reconnaissance Orbiter (MRO)NASA/JPL-Caltech/MSSS

The Mars 2020 rover will be launched in July or August 2020 from Cape Canaveral, Florida. NASA's Mars 2020 is basically the part of a larger program that includes a manned lunar mission aimed to land humans on earth's natural satellite by 2024. This mission named NASA's Artemis lunar project aimed to build a human base on the moon which is widely considered as the first step to achieve the ultimate goal, Mars colonization.

A few months back, a study conducted by researchers led by Regina Dass, a researcher at the Molecular Fungal Genetics and Mycotoxicology Laboratory, Department of Microbiology, School of Life Sciences, Pondicherry, India had suggested that alien life form in its basic form might be living on Mars. Scientists who took part in this study made this conclusion after analyzing Martian images taken by NASA's Curiosity Rover. The research report revealed that they have spotted algae, lichens, and mushrooms in 15 Martian images captured by Curiosity Rover.

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NASA terrified it could be shut out from the International Space Station next year – Express.co.uk

Posted: November 17, 2019 at 2:30 pm

The report blames commercial crew delays from Boeing and SpaceX, neither of whom are likely to be certified for regular flights to the ISS by the summer.SpaceX will have a certification review in January while Boeing will have to wait until the following month. The report concludes final vehicle certification for both contractors will likely be delayed at least until summer 2020 based on the number of ISS and CCP [commercial crew programme] certification requirements that remain to be verified and validated.

Space News report launch abort systems and parachutes are the biggest issues for both companies.

Only in April, a parachute test failure by SpaceX contributed to at least a 3-month delay in SpaceXs crewed test flight.

Boeing saw one of their three parachutes fail to open in a test earlier this month.

In the spring, the ISS crew will half from six to three with just one, Chris Cassidy from NASA.

NASA and non-Russian parters will be less able to work on the US On-Orbit Segment (USOS).

The report explains: Any reduction in the number of crew aboard the USOS would limit astronaut tasks primarily to operations and maintenance, leaving little time for scientific research.

NASA administrator Jim Bridenstine has made a formal request for seats on a Roscosmos spacecraft.

The Russian agency is yet to respond.

READ MORE:'God of Chaos Apophis asteroid may set world back to prehistoric times

The station has two sections, the Russian Orbital Segment operated by Russia and USOS.

The station is expected to operate until at least 2030.

236 people have been on board from 18 countries.

Major Tim Peake is the only Briton to have done so.

Currently on board are Italian commander Luca Parmiitano, Russian flight engineers Aleksandr Skvortsov and Oleg Skripockhka as well as American flight engineers Andrew Morgan, Christina Koch and Jessica Meir.

All the Americans on board are on their first spaceflight.

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Spacewalk today: Astronauts at International Space Station take on one of the most complex spacewalks ever – CBS News

Posted: at 2:30 pm

Two astronauts ventured outside the International Space Station Friday for the first of four spacewalks to repair a $2 billion cosmic ray detector, breezing through difficult work to prep the device for invasive surgery to splice in new coolant pumps and extend the instrument's life probing the composition of the universe.

"We're going to perform what could be considered open heart surgery on this amazing experiment," said Italian astronaut Luca Parmitano, the current space station commander.

The 7.5-ton patient in this case is the Alpha Magnetic Spectrometer, or AMS, the most expensive science instrument aboard the space station and one that was not designed to be serviced in orbit. As such, the "operation" is considered one of the most challenging since work to repair and upgrade the Hubble Space Telescope.

"It's definitely towards the top of the list, if not on the top," said Tara Jochim, the AMS repair manager at the Johnson Space Center in Houston.

Floating in the station's Quest airlock, Parmitano and NASA astronaut Drew Morgan switched their spacesuits to battery power at 6:39 a.m. EST to officially kick off the year's ninth spacewalk.

The last time Parmitano walked in space in July 2013 his suit malfunctioned, flooding his helmet with water and forcing an emergency return to the station's airlock. NASA developed procedures to prevent a recurrence and no similar problems have occurred since then.

The major objectives of Friday's spacewalk were to prep the AMS for its planned surgery, setting out tools and equipment before removing a protective debris shield, giving them access to the instrument's thermal control system.

After carefully tossing the debris shield overboard, the spacewalkers attached two handrails to help them move about the device and, reaching into the AMS, snipped a half dozen zip ties and cut a cord to fold back insulation blankets.

The work went much faster than expected and the astronauts were able to work through several items originally planned for their second spacewalk next Friday. That's when the actual repair work will begin. The third and fourth spacewalks will be officially scheduled after managers assess the results of the first two outings.

Parmitano and Morgan returned to the airlock, closed the hatch and began repressurizing at 1:18 p.m. to wrap up a six-hour 39-minute spacewalk, the 222nd since the station assembly began in 1998, the ninth so far this year, the third for Parmitano and the fourth for Morgan.

"I've got to tell you, you made the ground team awfully happy and proud of you guys today, just some excellent, excellent work," Canadian astronaut Jeremy Hansen radioed from mission control. "We are very, very pleased with where we stand moving forward, getting the Alpha Magnetic Spectrometer back up and running. So congratulations to all of you."

It took engineers and astronauts four years to come up with a workable repair plan, developing some two-dozen custom tools and testing procedures during multiple underwater training runs. Parmitano and Morgan completed seven full-duration training exercises before launching to the station in July.

"We had to go off and figure out how to create a work site, we had to build new handrails to install on existing hardware, we had to deal with existing sharp edges and in a lot of cases, we're creating new sharp edges using tools that have sharp edges on them," said Jochim.

"We did as much as we could to minimize that risk to the crew member and then, of course, to the (repair) of the payload itself," she said. "But they are certainly very challenging and technically difficult EVAs."

Launched in 2011 on the next-to-last space shuttle mission, the Alpha Magnetic Spectrometer, is one of the most expensive science instruments ever launched into space.

It is built around a powerful electromagnet that bends the trajectories of electrically charged cosmic ray particles created in supernova explosions and other extreme-energy events, allowing researchers studying the trajectories to characterize their velocities and energies.

The goal is to learn what happened to the antimatter thought to have been created in the big bang birth of the cosmos, to learn more about the unseen dark matter that permeates space and, possibly, gain insights into the nature of dark energy, the mysterious repulsive force that is speeding up the expansion of the universe.

Designed to operate for just three years, the AMS proved longer lived than expected, detecting more than 145 billion cosmic rays during eight-and-a-half years of operation. But the instrument has been hobbled in recent months by the staggered failures of four small pumps needed to circulate carbon dioxide coolant through its sensitive detectors.

To repair the AMS, Parmitano and Morgan will have to cut through eight small coolant lines and splice in, or "swage," new lines leading to a custom-built replacement pump module launched to the station earlier this month. The pump module will be installed during the third spacewalk.

"We're going to cut tubes, and then fuse them with other tubes (launched) from Earth and install a completely new pump to help the refrigeration work, keeping the magnet cold so the the Alpha Magnetic Spectrometer can work," Parmitano said. "This is really the first time any of these actions have been attempted."

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Life on the Space Station is about to get really weird and lonely – Wired.co.uk

Posted: at 2:30 pm

Right now, there are six astronauts aboard the International Space Station, floating 408km above our heads. But soon things could be about to get a lot lonelier up there. Delays in building new spacecraft to get astronauts into space mean that the next trio of astronauts set to join the ISS in April 2020 are facing the possibility of being the space stations lone occupants for six months.

It'll be the first time the ISS has had only three semi-permanent occupants since 2009, when it was expanded so it could comfortably fit six occupants at any one time. But for the last 10 years a crew of six has kept up with the ISS endless list of maintenance tasks and research projects. What will happen when this floating workforce is cut in half?

The next three astronauts to be sent up American Chris Cassidy, and Russians Nikolai Tikhonov and Andrei Babkin will travel in a Soyuz capsule. Since the retirement of the US Space Shuttle in 2011, all journeys to the ISS have taken place in these Russian-made spacecraft, which bring three people at a time. One Soyuz capsule is attached to the ISS, like a lifeboat, at all times, and the crew members who have been there the longest will take this capsule home. Three new astronauts arrive a couple of weeks later so apart from the short periods while crews are changed over, there are usually six astronauts and cosmonauts on the ISS at any one time.

This system has worked worked for nearly a decade, but for 2020, Nasa decided that instead of buying seats on Soyuz, it would rely on contracts with commercial companies SpaceX and Boeing for extra crew launches. But development of the commercial capsules has been delayed, with Boeing having trouble with their parachutes and SpaceXs Crew Dragon capsule exploding during tests.

In 2010 when Nasa prepared to shut down their Space Shuttle program, they gave commercial companies a combined $50m (38m) to design their own transport spacecraft. Its uncertain exactly when the commercial capsules will be ready as they need to pass rigorous safety tests first, so rather than paying for an extra Soyuz, Nasa has decided to prepare the next group of astronauts for what might happen if theyre left alone.

Over the years, ISS expedition experiments have made discoveries which will be vital if humanity wants to explore space further. Previous missions have revealed the effect of microgravity on the human body and the source of cosmic rays. But if the crew need to do general maintenance on the station, with fewer people on board there will be less time for other activities.

A large amount of experiments can be done with commanding from the ground so we're trying to to give preference to those, says Ruediger Seine, space training team leader at ESA's European Astronaut Centre. Space agencies managing experiments will have to pick which of their projects theyd like the astronauts to devote their limited time towards, and press pause on experiments that require more human intervention.

But some experiments might fare between without humans getting in the way. Some experiments actually might benefit from less people because of vibration, says Laura Forzcyk, founder of the consulting firm Astralytical who used to work for the ISS US National Laboratory. Even with three there are still a lot of vibrations. Some experiments just want to be left alone.

The limited crew will also mean more sharing of resources. The ISS itself is split into two sides Russian and American. The Russians usually operate on their side, while astronauts from the United States, Europe, Japan, and Canada operate on the other. However with such a small number of people on board, they need to work more cohesively. With only one American, the two Russians have been trained on how to use the US equipment. For example, each side has its own space suit both with different ways of operating but the astronauts and cosmonauts need to be trained in how to use both. Its a case of being prepared for all situations.

It's not easy to get from the Russian airlock to the American segment of the International Space Station. The additional training for the remaining crew members is to make sure that we're covering all contingencies, says Seine.

And while the experiments may appreciate being alone, the people may not. Experiments only take up part of astronaut's time on board the ISS. Like a typical working week on Earth, they have time off, in the evenings and on the weekends. Chris Cassidy, Nikolai Tikhonov and Andrei Babkin may not see another person from spring 2020, to when their mission finishes at the end of the year.

And 2020 could be the last point the ISS gets this quiet for a while. In 2019, Nasa announced that it would let tourists fly to the ISS from 2020 if they were willing to pay the 27,500 for the privilege. This isnt the first time this has happened seven people who arent employed by a space agency have gone to the ISS before. And it wont mean they are dead weight; anyone who gets sent up, professional or not, will be given tasks and help out in any way they can.

But until then, the trio of astronauts will have to endure the mental stress that comes with isolation. Research has found that along with psychological effects caused by adjusting to the novel situation of being in space, astronauts also often struggle with anxiety and depression. ISS astronauts, despite being kept busy with experiments, will still have opportunities to socialise they try to have at least one shared meal a day, and receive plenty of contact from their friends and family.

Michael Lopez-Alegria, who has flown the longest US space station mission to date, went up to the International Space Station in 2006 when the crew was still small. He was there with only two other people at a time, but managed to not feel too lonely during the mission.

I like the small size crew, because we tend to bond more as a unit, he says. Sometimes there can be a divide by culture when there are more people. We had one Russian, me and then the third person was either a German or an American, and so we tended to be more cohesive and spend more time together.

Lopez-Alegria found that looking out at Earth helped him feel closer to home, and in 2010, an observatory module was added to the ISS to create an even bigger window to help with astronauts mental health. I wish I were going back myself, he says.

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Life on the Space Station is about to get really weird and lonely - Wired.co.uk

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‘Get back to the moon and forget the orbiting space station’ – Politico

Posted: at 2:30 pm

He makes no secret of his current views that the space agency is on the wrong track by continuing to put so much of its scarce resources into the Space Launch System rocket and the Orion capsule after so many years of delays and when new and cheaper commercial alternatives are so promising.

People have fallen in love with them but they got old and expensive, and I think they're more worried about keeping some of the aerospace companies in fit shape than the American taxpayer, he complains.

Gibson supports returning astronauts to the moon, but he's also among the vocal group of space insiders who contend that building a lunar Space Station first will just slow things down.

Nor is he convinced that extending NASAs primary role in running the International Space Station makes sense, given all the other competing goals.

Gibson sat down with POLITICO last weekend on the sidelines of Space Vision 2019, hosted by Students for the Exploration and Development of Space at Arizona State University.

This transcript has been edited for length and clarity.

You were among the first astronauts who were scientists and not military pilots.

The test pilots thought they were going to rule the world forever. Congress said, 'Youve got to get some science in the program, and the way to do that is get some who have science backgrounds to go flying in space.'

So, begrudgingly NASA did that, and I think the test pilots in the program said, 'All right, bring them in here. They'll quit, flunk out, or kill themselves. And we won't have to deal with them again.' But when we came in there, they found out we could walk and chew gum at the same time.

Once we got working with each other, we gained respect for each other and it started to come together.

Do you think returning to the moon should be NASAs main exploration goal?

I know we are very limited in our budget, and I want to see things happen quickly. I think the best place is a facility right there on the moon itself.

So, go directly to the surface and not build the lunar Gateway? I just don't see the advantage of it. I listened, and I've studied, and I've tried to see the advantage of that Space Station. But to me it never registers as superior, or even better than doing it the simple way.

Get back to the moon and forget the orbiting Space Station. If that is needed in the future, show that it really is needed.

You've got the ability to produce oxidizer and fuel from the resources on the moon. So, why don't we go there, create those things at some point on the surface either the North or South Pole?

The South Pole, I think, is a little bit better. And if you want to go up to the pole and study the ice and other resources from there, it's a small hop ... to get to any other spot in that hemisphere. And that can be happen very easily.

You've spent a lot of time in space. Are we prepared for the physical rigors of such long duration missions to deep space?

I think there's a real issue. You don't want to living in lunar orbit or Mars orbit for a long period of time. That's why I think it's great to just go to the surface to shield yourself [from the radiation].

Then, if you want to go somewhere, you go out and, obviously, you've got to suffer whatever radiation there is, and youve got to have your spacecraft or your spacesuit to give you some added protection.

You have also expressed concerns about the cost and capability of the Space Launch System and Orion spacecraft.

SpaceX could be a lot cheaper than what we're going to do with the SLS and maybe even the Orion, as nice as those programs are.

People have fallen in love with them, but they got old and expensive. ... I think they're more worried about keeping some of the aerospace companies in fit shape than the American taxpayer.

Do you think NASA should extend operations on the ISS beyond 2024?

The question is, What are we getting for it, versus other things that we can do with that money? We can cut back a little bit, let the other nations pick up even more.

I have to ask what we're getting back from it and what else we want to do in space? I think as we get to where we're wanting to go back to the moon and onto Mars the Space Station is probably going to lose some of its support.

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'Get back to the moon and forget the orbiting space station' - Politico

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The story behind the first batch of cookies in space and the first zero-gravity oven – CNN

Posted: at 2:30 pm

Typically, this is good advice, but for the astronauts aboard the International Space Station, tasked with baking the first batch of cookies in space, it may be tough to follow. And understandably so. For the last year and a half, husband and wife duo Ian and Jordana Fichtenbaum, founders of Zero G Kitchen, have been developing the first zero-gravity oven that could revolutionize space food and bring a taste of home to astronauts who dearly miss it. Last week, the oven arrived at the space station. No date has yet been announced for it to be tested.

The Fichtenbaums' mission is both simple and highly technical: "We want to build a kitchen in space, one piece at a time, and partner with companies, educators and researchers all along the way," said Ian Fichtenbaum.

Designing an oven capable of baking space cookies is no easy feat. Everyday tasks are more difficult in space, which lacks the force of gravity to keep objects from floating around -- and baking presents its own unique challenges. Traditional convection ovens function by utilizing gravitational properties; "the hot air rises, the cool air falls," explained Abby Dickes, Nanoracks' marketing director.

Then there's the challenge of keeping food secure and stationary while it bakes. To complicate things further, the oven must run on a limited power supply, so as not to blow a fuse on the space station.

But the zero-gravity oven was designed to circumvent these issues. It's composed of a sleek, cylindrical chamber that houses an insertable silicone frame, which surrounds the food to hold it in place. Cylindrical heating coils focus the heat on the food in the center of the chamber and rise to temperature much more slowly than traditional ovens, to accommodate the power constraints.

"The oven went through a few different iterations, but the final creation ended up being very chic, very beautiful, and now it's up on the space station ready to bake some DoubleTree cookies -- and hopefully after that, all kinds of other creations," says Ian Fichtenbaum.

What might those other creations be? "Right now it's best to stick with things that are patty-size and shape -- a roll, a meatball," said Jordana Fichtenbaum.

What about more composed dishes? A tiny casserole, perhaps? "Yeah, maybe a mini casserole," says Ian Fichtenbaum.

But first, cookies. The irony, of course, is that the cookies are not technically meant to be eaten. They are, after all, the product of a science experiment and, what's more, one that's never been conducted before.

"The top priority for everyone who works on the space station is the safety of the crew on board," said Dickes. Some cookies will be reserved for analysis. For the rest, taste-testing will be at the baker's discretion.

For astronauts who choose to eat the cookies, the real question will be whether they taste just as good as those you get at any DoubleTree here on Earth. While the proof will be in the pudding, Dickes has high hopes.

"You have to start with great ingredients, which we know we're doing because we've eaten far too many of these cookies," she said. "I think they're going to look different -- like more of a spherical blob shape, which honestly just sounds gooey and delicious."

But just in case the first batch doesn't turn out to be edible, a tin of pre-baked DoubleTree cookies was sent up to the space station along with the oven.

The shape of the cookie may lend itself perfectly for this experiment, but that's not the only reason it was chosen for the zero-gravity oven's maiden voyage.

"It's a symbol of hospitality and we're trying to make space travel more hospitable for the future," said Dickes. "A cookie represents the perfect symbol of everything we're trying to do in this mission."

Oh yeah, and it's delicious.

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