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Surprising No One, The FBI’s Watchdog Says The Agency Is Handling Its Informants Improperly – Techdirt
Posted: November 23, 2019 at 11:56 am
from the consummate-professionals dept
Confidential informants are only as trustworthy as their law enforcement handlers. The FBI isn't the only agency to have problems with handling confidential human sources (CHSs), but it's one of the more notorious, thanks to its botched handling of James "Whitey" Bulger.
This questionable legacy lives on, as the FBI's Inspector General reports. "Whitey" Bulger is name-checked early on in the report [PDF], setting an appropriately cautionary tone for the rest of the document.
The FBI loves its CHSs. Without them, it can't radicalize random people into arrestable would-be terrorists. Without the assistance of criminals, it apparently can't go after other criminals. While a certain amount of criminal activity is necessary to maintain cover, the FBI doesn't appear to be keeping close tabs on its informants, which isn't going to minimize collateral criminal damage during investigations.
The FBI spends $42 million a year paying CHSs but doesn't seem to care whether that money is being wisely spent. The actual number of informants the FBI employs is redacted, but the IG notes that 20% of these are "long-term," having been used by the FBI for at least five years.
The longevity of CHSs is a concern that the FBI doesn't seem to be concerned about. The longer the FBI uses the same informants, the greater the risk they'll be exposed. But beyond that, there's the problem of familiarity. Every five years, CHSs are supposed to be assigned new handlers in order to prevent agents from becoming too close to their charges. The FBI isn't doing this. In fact, the FBI doesn't appear to track length of service with any accuracy, which means the agency potentially has more "Whitey" Bulgers on its hands: criminals whose close relationship with a single handler allows them to engage in far more criminal activity than guidelines (and human decency) would allow.
According to this report, the FBI's inability to properly track CHSs has led to a backlog of required "enhanced reviews" -- the validation process put in place to ensure proper handling of long-term informants. To make matters worse, the FBI unilaterally decided to remove "long-term" as a potential risk factor for CHSs, allowing these problematic informant-handler relationships to fly under the radar.
The few people performing CHS validations are further restricted by FBI policy. It's almost as though the FBI has decided that what it doesn't know can't hurt it. The limitations prevent reviewers from accessing anything more than one year of files, denies them access to other helpful FBI databases, and discourages them from providing recommendations or drawing conclusions from the limited info they can actually access.
The FBI also has problems with automation. The system does not automatically flag CHSs when they hit the five-year mark. This has to be done manually by the informant's handler. Without this feature, handlers and reviewers are left in the dark about CHS longevity, which further hinders the review process and adds to the backlog the FBI will never catch up to at its current review pace.
The FBI knows this is a problem but continues not to care.
Although the FBI has considered improvements to address the shortcomings, it has not taken corrective action by implementing an automated mechanism in Delta.
This refusal to fix this issue has lead to further failures up the line. Handlers with long-term CHSs are supposed to obtain approval from Special Agents in Charge (SAC) for continued handling of these informants. Since the system doesn't flag long-term informants, SACs are not automatically notified and CHSs continued to be handled by the same agents in direct violation of FBI policy.
The problem becomes exponential once FBI field offices are factored in. CHSs in use at field offices are subject to the same review, but review personnel at FBI HQ appear to believe they are there to grease the wheels, not act as oversight.
Several FBI officials suggested to us that there is a risk that field offices may avoid the selection of certain CHSs for validation review because the field offices may wish to continue using those CHSs despite the presence of particular risk factors. In fact, one of these officials told us that the field offices may be sending "softballs," meaning field offices may be sending CHSs lacking any significant risk factors.
It's not just the field offices. The FBI is actively avoiding documenting negative information about CHSs to subvert the justice system. It's just that simple.
[O]ne Intelligence Analyst told us that he was permitted to recommend a CHS receive a polygraph or operational test to the handling agent by phone by not permitted to document the recommendation in the CHS's validation report. Additionally, multiple FBI officials told us that they believe that field offices do not want negative information documented in a CHS file due to criminal discovery concerns and concerns about the CHS's ability to testify. For example, one FBI official told us that some U.S. Attorney's offices will not use a CHS at trial if there is negative documentation in the CHS's file.
The Inspector General obviously recommends the FBI stop doing this sort of stuff but it's obviously already entrenched in the FBI's culture. Officials recognize field offices are harboring shady CHSs but have done almost nothing about it.
Then there's the infosec part. Confidentiality is key to the handling of confidential human sources. But FBI agents don't appear to care that they're putting their sources at risk by carelessly handling communications. Since no policy specifically forbids the use of government equipment to contact CHSs, many agents simply use their FBI-issued phones. The use of electronic communication methods is discouraged, but simply telling people they shouldn't do something is rarely an effective deterrent.
In addition, the central CHS database is on a shared site that grants access to personnel not involved with handling human sources. This increases the risk to CHSs by eliminating the "confidentiality" of the arrangement. The only thing mitigating this increased risk is the fact that the database is riddled with errors and incomplete information. Incompetence might save the day as CHS files improperly accessed may not contain enough accurate information to expose a confidential source. Win-win, I guess.
That the FBI concurs with all of the OIG's recommendations is hardly heartening. Included in this review are recommendations issued by the OIG six years ago in response to CHS handling issues that occurred in 2006. To date, the FBI has only implemented five of the eleven recommendations from the 2013 report.
It's a mess. And it's a mess the FBI continues to make worse. The underlying problem appears to be the FBI's unwillingness to cut loose informants who might be a liability. The only effort that gets made in these situations is to find some way to work around an already-very permissive system to ensure agents can retain the CHSs. A system that fails to flag risk factors or periodic review periods is the kind of system that allows the FBI to engage in business as usual with just enough plausible deniability to avoid the few accountability tripwires built into the system.
Filed Under: fbi, informants
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Surprising No One, The FBI's Watchdog Says The Agency Is Handling Its Informants Improperly - Techdirt
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The Future of Meat – Truthdig
Posted: at 11:56 am
The Meat Question: Animals, Humans, and the Deep History of Food
A book by Josh Berson
In the movie My Big Fat Greek Wedding, Aunt Voula, played by Andrea Martin, learns that her nieces fiance is a vegetarian. She says, He dont eat no meat?WHAT DO YOU MEAN HE DONT EAT NO MEAT? Oh, thats OK, thats OK, I make lamb!
Its funnyor is it? For those of us who eschew consuming animals and their byproducts, its hard to understand why most people today still enjoy eating flesh, seeing meat as something rather than someone. In The Meat Question: Animals, Humans, and the Deep History of Food, Josh Berson digs deep, literally, going back to the earliest times of human existence to find out when and how and why our relationship with animals as food began. The book considers three questions: 1) Did meat make us human? 2) Is growing affluence the cause of increased meat consumption? and 3) Will we see the end of meat?
As a vegan for 31 years and vegetarian for even longer, I rejoice with every new study or book published on the devasting impact that eating animals has on our health, quality of life and longevity. With hundreds and hundreds of scientific references, surely, I think, people will reduce or eliminate their meat consumption in order to reduce their risk of chronic disease. So many people have shared their stories in films, books and websites on how they reversed their heart disease or diabetes, achieved a normal weight, and regained their lives, by discovering a healthy, plant-based diet.
And yet, the consumption of animal flesh and animal byproducts continues to rise. The world population is projected to reach 9.6 billion by 2050 and people will be devouring more meat than ever before. There is no longer enough land mass on Earth to allow livestock to graze freely before slaughter. Today, the CAFO (concentrated animal feeding operation, AKA the factory farm) is the answer, but for the individual animals being raised in a CAFO for food, it is hell on earth.
What about the environment? As stinking lagoons of untreated livestock excrement are piled higher and deeper, surely we would realize our folly of raising tens of billions of animals for food. But no, it seems no amount of air and water pollution, greenhouse gas emissions, rainforest destruction, aquifer depletion, soil exhaustion, species extinction, etc. can curtail our desire for consuming flesh.
Click here to read long excerpts from The Meat Question at Google Books.
I have waited for decades for the discussion on climate change to heat up, for it to be considered for regulation in government policy and for it to headline mainstream news on a regular basis. Are we there yet? The late Robert Goodland, lead environmental adviser at the World Bank Group, wrote passionately and profusely about climate change and how we could all, simply and easily, prevent our demise by choosing plants instead of animals for food. Mitigating global warming by changing our diet was his plea, because it would buy us time to transition our factories and modes of transportation to sustainable energy sources.
Was his message heard? Do we have the capacity to hear this message?
Berson acknowledges the devastating impact on health, environment and animals due to meat consumption very briefly, early in his books prologue. He writes as if we all know this information already, no need to elaborate in detailalthough he does paint the nightmarish image of current reality, transporting cattle from Australia to China by air! We use all our best inventions, concentrating cattle into airplanes to satisfy the gluttonous desire for flesh while making a nice profit. Is no thought made of the reckless use of energy resources or abundant release of greenhouse gas emissions in this scenario? We have created our own little shop of horrors at home on Earth, responding to the escalating cry, Feed Me!
Are we who we areare we humanbecause we eat meat? To address the first question, Berson presents to us a dry and academic history of humankind. This is not easy reading. As we travel to periods 1 million to 5 million years ago, the text is riddled with archeological terms that even an above-average reader would not be familiar with. It takes patience to comprehend it all, moving back and forth through ancient and unfamiliar times.
Berson explains that our evolutionary history was a result of our diet versatilitybeing able to find and consume a variety of plant and animal-based foods, available in different periods and locations. Berson addresses the tenuous relationship between the consumption of meat and the evolution of human brains:
Where do we get the energy to run our big brains? Over the past twenty-five years, this has been a key question in evolutionary anthropology. For many observers, our expensive brains represent exhibit A in the case for meats role in human evolution. Meat, the argument goes, supported encephalization [the evolution of large brains] [But] the brain cant do much with the energy in meat. The brain relies on glucose as its primary fuel the energy in the lean meat of wild ungulates is mainly in the form of protein. The body has a limited capacity to convert amino acids into sugars. Protein does not represent a sustainable source of energy for the maintenance of nervous tissue.
Berson goes on to explain that energy is not the sole expense of the human brain, which is 50% to 60% lipid by dry mass. DHA (omega-3 docosahexaenoic acid) is vital in supporting the high lipid content of our brains. DHA can be hard to find in human dietsits primary direct source is aquatic foods. It can, however, be synthesized from alpha-linolenic acid (LNA). [C]linical evidence indicates dietary LNA represents a more-than-adequate source of DHA for the growth and maintenance of the central nervous system, Berson writes. Where are the terrestrial dietary sources of alpha-linolenic acid? Its highly concentrated in chloroplast membranes, so leafy green plants represent a strong source, as do mosses, the fatty tissue of herbivores that consume these things, and the usual range of oilseeds, including flax, hemp, and walnuts.
He concludes, Meat may well have played a role in buffering the vagaries of access to a higher-quality diet in early humans. But it wasnt because it was essential to brain development. Nor is meat essential to how we eat in the future.
Later in the book, we arrive in the present day. Here, we can scrutinize our history more carefully as the abundance of evidence improves resolution. Question 2 is addressed: Is growing affluence the cause of increased meat consumption? To balance Western influence dominating the telling of human history, Berson writes, I offer an Asia-Pacific perspective on the modern meat economy. My aim is to nudge the food systems literature away from the North Atlantic and toward those parts of the world whose tastes, expertise, and climate will dominate global patterns of change in diet over the next two or three generations. We learn that affluence alone does not drive the demand for meat. Rather a complicated economic and political system has been created that forces those disempowered, impoverished individuals to choose the convenience of cheap meat because they have no access to affordable alternatives.
Berson writes, Until we recognize that marginalized humans and animals raised under industrial conditions occupy coordinate roles in a single system of economic violence, we will make no progress unworking meats power.
In the epilogue we learn that Berson has been a vegetarian for 25 years and a vegan for 19, except for a handful of exceptions. He admits his original motivation was unclear but over time it was about reducing his footprint: I wanted to limit my claim on the Earths resources to levels that would allow the largest number of people to enjoy the quality of life that I took for granted. He began to question his reasons for being vegan after about a decade, which became the motivation for this book. The dispassionate tone throughout is intentional; Berson desired to present information as objectively as possible, without judgment that might alienate the reader.
Will we ever see the end of meat? The author believes if humanity survives, its possible that few if any animals will be on our plate. After reading The Meat Question, I have a better understanding of why it is not effective to use single issue arguments like health, environment, climate change and animal cruelty to convince people to reduce or eliminate their animal consumption:
To imagine a world in which humans no longer get any part of their subsistence from animals is to imagine a world where the bond of economic necessity, of precariousness, between humans and animals has been succeeded by a bond of mutual regard, among humans and on the part of humans for other living things. This is a more radical vision than that which underlies arguments for the cessation of meat eating on grounds of health, or carbon footprint, or animal sentience.
Berson shows us how to think about eating animals in broader terms. Gambling on food prices with agricultural derivatives and investing in agricultural land acquisitions negatively impact the access to adequate food. Meat consumption is one piece of a complex and violent capitalist system.
There was one question I couldnt help but ask myself while reading The Meat Question: Are humans naturally violent? Berson concludes with this question as well, asking whether human beings are fundamentally cruel, condemned to reduce one another to lumps of meat. He acknowledges that if we dont want to accept systemic violence as our reality, a divergence will be required, in diet among other things, as radical as any we have experienced before.
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The Future of Meat - Truthdig
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30-year-old Harvard study on longevity: Five daily habits to follow for a healthy living – Republic World – Republic World
Posted: at 11:56 am
Scientists at Harvard have reportedly been studying human anatomyfor years. From researching about how to eat healthy to studying what goes on inside our body, they know it all. Recently, they came up with research which discovered the 5 rules an individual should follow to lead a healthy life. The study done by Havard is 30-year long study which gives 5 rules one should compulsorily follow:
Also Read:Healthy Diet: Benefits Of Protein And Fiber In Your Diet
The Lancet stated that 1 in every 5 death globally is associated with a p[oor diet. It is believed that we consume double the recommended amount of processed meat which affects our body causing obesity and other body-related diseases. The Havard T.H Chan School of Public healths study found out that adding enough fruits, nuts, whole grains, fruits and vegetables can lower the risk of heart attack stroke by 20 per cent.
Exercising regularly is something every dietician or nutritionist might suggest. According to the World Health Organization, People who are not active enough have 20-30 per centincreased their risk of death. Experts in this field have advised that a healthy adult should exercise for 150 minutes every week.
Also Read:Eye Health And Eyesight: 5 Best Foods To Include In Your Diet
A good diet and exercising regularly helps you maintain a healthy weight. The United Nations study has found out that around 800 million people around the world are obese and the number has tripled since 2016.
It is recommended to not intake too much of alcohol. The taste of wine has been found to engage the brain than any other human behaviour. The Scripps research institute found that an ingredient in red wine can also help to reduce stress but it should be consumed in moderation, preferably justa glass or two. Nature claimed that a moderate amount of wine can be beneficial and too much alcohol is a health risk.
Also Read:Food Combinations That May Sound Weird And Gross But Taste Delicious
Smoking is injurious to health and every individual is aware of it. If a person quits smoking, within a year of quitting smoking, your risk of heart disease drops by half. After 10 years, the risk of lung cancer falls by 50 per cent, as claimed by the World Health Organization. Giving up smoking also reduces the chance of impotence and infertility among people who wish to be parents. WHO also found that maintaining these healthy habits add 12 years of life for men and 14 for women.
Also Read:Fitness Tips: Indoor Exercises That You Can Do To Stay Healthy And Fit
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30-year-old Harvard study on longevity: Five daily habits to follow for a healthy living - Republic World - Republic World
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What the termite mound ‘snowmen’ of the NT can tell us about human nature – The Conversation AU
Posted: at 11:56 am
The Stuart Highway in the Northern Territory is dotted with around 300 termite mounds, dressed as people. They are reminiscent of giant, ochre coloured snowmen in their distinctly human forms of decoration.
These tall, colourful mounds variously sport scarves, caps, singlets, shirts, sunhats, bras, hard hats and even a beer can. They start just below Darwin, near the Noonamah Hotel, and occur all the way down to Kulgara, just north of the South Australian border. This covers around 1,800 kilometres.
The snowmen are an irreverent, larrikin, Northern Territorian phenomenon. But who created them? And what can they teach us about fundamental human behaviours?
Termite mounds occur naturally. They are made of clay, soil, sand and other natural materials, bound together with the saliva of termites. They occur globally and can reach as high as five metres.
In the NT, the first snowmen appeared during the 1970s. More quickly followed. They appear on both public and private land, lining major highways and rural roads and extending into national parks.
Over the years, many people have made these snowmen. Some were made by roadworkers, staying at roadside camps along the highway, with limited access to towns and entertainment but plenty of work clothing. Some were made by the owners of rural and remote properties. Some were made by fisherman traversing to remote fishing locations. Some may have been decorated by tourists.
The manager of the Royal Flying Doctor Service Tourist Facility, Samantha Bennett, is a Territorian born and bred. She says of the mounds:
Sometimes the clothing is changed according to festive calenders. They dont do Halloween, but they definitely do Christmas and Australia Day. They dress them up with flags and high viz clothing, which is cool because you can see them from a distance. Sometimes, they are used to help with directions. They mark the location of a driveway in a remote area or turnoffs to secret fishing spots.
The snowmen are actually snow people men, women and children. Some are arranged in family groups. Gender is marked by clothing. Economic status can be discerned through the use of silk scarves, resort wear or hard hats.
The NT has the highest rate of beer drinking in Australia. Not that long ago, it had the highest rate of alcohol consumption in the world. Perhaps unsurprisingly then, beer cans are held by some snowmen.
The snowmen are part of a wider cultural landscape in the NT. If you go to the Coburg Peninsula and lose one of your thongs, you put the remaining thong on the thong tree: a tree covered top to bottom with old rubber thongs.
Then there is the fence of shame on Andreas Avenue at Dundee Beach, west of Darwin. This is where you put your fishing rod if you have broken it during your trip.
There is material evidence that the snowman tradition has some longevity. In some cases, the clothing is in a dilapidated state. In others, the termites have renewed their building efforts on top of the clothes.
It is unlikely that the snowmen were created by Aboriginal people. As Barunga resident Isaac Pamakal explains: Aboriginal people dont do that, because that might make people sick.
Termite mounds are woven into NT Aboriginal belief systems. In some areas, there is a belief that anyone who knocks over a mound will get diarrhoea. Indeed, powerful Indigenous people have been known to put someones clothes onto a termite mound in order to make that person sick. The intended victim would be identified by the sweat on their clothing (which contains their DNA). (This link between sweat and DNA is an example of Indigenous science, which is increasingly being drawn on.)
However, termite mounds are mostly known, in the NT and around the world, for their medicinal properties. They contain high proportions of kaolin, used for the treatment of gastric-disorders in both traditional and modern pharmacologies.
Francoise Foti has conducted research in two NT Aboriginal communities, Nauiyu Nambiyu (Daly River) and Elliott. She records people consuming small quantities of termite mounds to deal with gastric disorders or after eating certain foods like yams, turtle or goannas. Similarly, termite mound material is sometimes eaten during pregnancy or lactation as it contains iron and calcium.
The urge to humanise inanimate objects is a global phenomenon through both time and space. For thousands of years, humans have had a penchant for making animals and things look like people.
This is most clearly shown in a style of rock art known as therianthropes, which depicts beings that have both human and animal characteristics. It also manifests in depictions of mermaids, centaurs and other mythical creatures.
So while they are special, the snowmen of the NT are not unique. They are simply another example of a human need to reinvent the world in our own image.
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What the termite mound 'snowmen' of the NT can tell us about human nature - The Conversation AU
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Breakthrough Gene Therapy Clinical Trial is the World’s First That Aims to Reverse 20 Years of Aging in Humans – PRNewswire
Posted: at 11:56 am
MANHATTAN, Kan., Nov. 21, 2019 /PRNewswire/ -- Libella Gene Therapeutics, LLC("Libella") announces an institutional review board (IRB)-approved pay-to-play clinical trial in Colombia (South America) using gene therapy that aims to treat and ultimately cure aging. This could lead to Libella offering the world's only treatment to cure and reverse aging by 20 years.
Under Libella's pay-to-play model, trial participants will be enrolled in their country of origin after paying$1 million. Participants will travel to Colombia to sign their informed consent and to receive the Libella gene therapy under a strictly controlled hospital environment.
Traditionally, aging has been viewed as a natural process. This view has shifted, and now scientists believe that aging should be seen as a disease. The research in this field has led to the belief that the kingpin of aging in humans is the shortening of our telomeres.
Telomeres are the body's biological clock. Every time a cell divides, telomeres shorten, and our cells become less efficient at dividing again. This is why we age. A significant number of scientific peer-reviewed studies have confirmed this. Some of these studies have shown actual age reversal in every way imaginable simply by lengthening telomeres.
Bill Andrews, Ph.D., Libella's Chief Scientific Officer, has developed a gene therapy that aims to lengthen telomeres. Dr. Andrew's gene therapy delivery system has been demonstrated as safe with minimal adverse reactions in about 200 clinical trials. Dr. Andrews led the research at Geron Corporation over 20 years ago that initially discovered human telomerase and was part of the team that led the initial experiments related to telomerase induction and cancer.
Telomerase gene therapy in mice delays aging and increases longevity. Libella's clinical trial involves a new gene-therapy using a proprietary AAV Reverse (hTERT) Transcriptase enzyme and aims to lengthen telomeres. Libella believes that lengthening telomeres is the key to treating and possibly curing aging.
Libella's clinical trial has been posted at the United States National Library of Medicine (NLM)'s clinicaltrials.gov database. Libella is the world's first and only gene therapy company with a clinical trial posted at clinicaltrials.gov that aims to reverse the condition of aging.
On why they decided to conduct its project outside the United States, Libella's President, Dr. Jeff Mathis, said, "Traditional clinical trials in the U.S. can take years and millions, or even billions,of dollars. The research and techniques that have been proven to work are ready now. We believe we have the scientist, the technology, the physicians, and the lab partners that are necessary to get this trial done faster and at a lower cost in Colombia."
Media Contact:Osvaldo R. Martinez-ClarkPhone: +1 (786) 471-7814Email: ozclark@libellagt.com
Related Files
curing_aging_booklet.pdf
Related Images
william-bill-andrews-ph-d.jpg William (Bill) Andrews, Ph.D. Dr. Bill Andrews is a scientist who has spent his entire life trying to defeat the processes that cause us to age. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including The Immortalists documentary.
Related Links
Dr. Bill Andrews speech at RAADfest 2018 (Sept 21, San Diego, CA)
bioaccess: Libella's CRO partner in Colombia.
SOURCE Libella Gene Therapeutics, LLC
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Missing Link To Longevity Discovered In The Plant Kingdom – Texas A&M University
Posted: at 11:51 am
lead researcher Dorothy Shippen, Ph.D., (left), graduate student Jiarui Song, first author (center) and postdoctoral fellow Claudia Castillo-Gonzlez, second author (right).
Texas A&M AgriLife
A breakthrough discovery by Texas A&M University and Arizona State University professors could provide a key component in understanding the human aging process and even aid in the battle against cancer.
Dorothy Shippen, Ph.D., is a University Distinguished Professor and Regents Fellow in Texas A&MsDepartment of Biochemistry and Biophysicsand withTexas A&M AgriLife Research, College Station.
Shippen co-led a study with Julian Chen, Ph.D., professor of biochemistry, Arizona State Universitys School of Molecular Sciences. First author, Jiarui Song, is a graduate student with Shippen.
Their study, The conserved structure of plant telomerase RNA provides the missing link for an evolutionary pathway from ciliates to humans, is being published in the Proceedings of the National Academy of Sciences.
Our discovery of this key component of the telomerase enzyme in the plant kingdom provides an evolutionary bridge, and a novel path forward, for understanding how humans keep their DNA safe and enable cells to divide indefinitely, Shippen said.
Moreover, since plants often evolve interesting solutions to fundamental biological problems, some of the lessons we learn from plant telomerases may provide new ways for addressing stem cell disease and cancer.
We found a core component of the telomerase enzyme that had been missing all these years, Shippen said. And by finding this component in plants, we not only learn new lessons about how telomerase evolved, but we also open the door to learn new things about the human enzyme.
Back in 2001, Shippen published a paper outlining the discovery of the catalytic subunit of the telomerase enzyme from plants. The catalytic component is one of two absolutely critical parts of the enzyme, and it is now very well understood.
However, the second component, the RNA subunit, that provides the enzyme with information about what to do with chromosome ends, was missing.
Our new discovery is the RNA subunit of telomerase from the plant kingdom. In the plant telomerase RNA, we can now see the signatures for the human telomerase and telomerase from simple organisms like bakers yeast and the microbes in pond scum.
The missing piece always was this subunit. Now that we have found the correct one, its opened up a lot of interesting insights.
Plants have different, innovative solutions to so many biological challenges, and insight into these may provide important clues on how human telomerase is regulated, she said.
We can study the telomerase enzyme more deeply and see so much more now, and it can help us understand how the human enzyme is going to work. It really is this missing middle ground.
In the 1930s, Barbara McClintockwas studying the behavior of chromosomes in maize and was one of the first scientists to appreciate the importance of telomeres.The Shippen Labin the 1990s followed up on the pioneering work of McClintock in model plant systems and discovered the telomerase enzyme, which is required for maintaining these structures on the ends of chromosomes.
Shippens longtime studies on telomerase, which play an essential role in chromosome stability and cell proliferation capacity, has led her to be considered the worlds expert in plant telomere research.
The telomere is like a biological clock. There is a certain amount of telomeric DNA at the end of chromosomes. As cells divide, they lose part of this DNA.
She has likened telomeres to the plastic tip on the end of a shoelace they form a protective seal on the ends of chromosomes in plants and animals. Like the plastic tip that wears out, allowing the shoelace to fray and become hard to use, so does the telomere break down in most cells in the human body over time.
The telomerase enzyme is capable of replenishing the lost DNA at chromosome ends and it is available in cells that are immortal, Shippen said. Its active in the stem cells, but not active in other places of the body normally.
Theres a whole connection between immortality and telomerase that needs to be studied.
Why is telomerase only active in stem cells, turned off in other cells and why does it get reactivated in cancer cells? Shippen said. Weve learned a lot about the human telomerase from pond scum, but plants can provide still more clues because their growth and development is so plastic. If you cut a flower from a plant growing in the garden, it will grow another flower. But if you cut off the tip of your finger, you wont be growing a new one.
Its a big mystery.
But Shippen said the plant telomerase is still very similar to the human telomerase.
It is remarkable that even in plants, telomerase is active only in cells that need to divide many times.
She expects that what is learned in the plant system will ultimately be translatable and have significant impact in human medicine.
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To Improve Public Health, Medicine Regulators Worldwide Should Collaborate, Remove Barriers to Sharing Information, Says New Report – National…
Posted: November 21, 2019 at 5:46 pm
Nov. 21, 2019
WASHINGTON Medicine regulatory authorities including the U.S. Food and Drug Administration (FDA) should strengthen cooperation with other countries regulators to ensure the quality, safety, and efficacy of medicines, says a new report from the National Academies of Sciences, Engineering, and Medicine. Regulating Medicines in a Globalized World: The Need for Increased Reliance Among Regulators contains recommendations to promote information sharing among RAs with the aim of protecting public health, ensuring faster access to critical medicines, and encouraging innovation in medicine and technology.
Today, drug development is increasingly global. An estimated 40 percent of medicines and 80 percent of active pharmaceutical ingredients used by Americans are made overseas. Different countries have different rules, regulations, and standards for the review and approval of new medicines. However, they are often unable to share inspection reports and other critical safety information with each other, because such reports are heavily redacted to protect trade secrets and other confidential information.
No regulator has all the human and technical resources it needs to meet all of its public health responsibilities, especially as their workloads increase due to the growing complexity of medicines; societal expectations for faster drug approvals; and the rising demand for inspections of manufacturing facilities overseas. Reliance and recognition arrangements enable regulators to share information and increase the transparency of each others activities; to optimize limited human and financial resources; to build expertise in specialized and emerging regulatory areas (such as gene therapies and biosimilars); and to mobilize resources in the event of a drug shortage or public health emergency.
Reliance is when a regulatory authority considers anothers work (such as inspection and scientific assessment reports) to inform its own regulatory decisions. Recognition the highest level of which is a mutual recognition agreement (MRA) is when a regulator not only relies on the work of another regulator, but also accepts and adopts the other regulators decisions. Smaller and under-resourced regulators often enter these arrangements with better-resourced countries to strengthen their capacity. However, it is up to the countrys regulatory authority to decide whether to approve a medicine. Entering one of these arrangements does not mean giving up decision-making responsibilities, the report says.
In order for regulatory authorities to build upon and enter new recognition and reliance arrangements, impediments to information sharing should be removed. Medicine regulatory authorities should consider sharing full, unredacted reports to help countries make better-informed, sovereign decisions about the approval of medicines, the report says. In addition, the FDA and Congress should re-evaluate such confidentiality restrictions and ensure that current redaction practices promote information sharing while protecting personal data.
The report identifies several potential public health benefits of reliance and recognition arrangements. These arrangements could allow for patients and consumers to gain faster access to quality medicines. For example, following the Zika outbreak of 2016, the World Health Organization (WHO) encouraged reliance as a way to expedite market access to tests, vaccines, and treatments for priority diseases. In the aftermath of Hurricane Maria in Puerto Rico a pharmaceutical manufacturing hub the use of reliance arrangements would have allowed regulators to share information to assess alternative manufacturing sites.
Greater cooperation between national regulators could help identify substandard or falsified medicines before they are approved or exported, says the report. It could also prevent duplicative activities, such as multiple RAs inspecting the same low-risk manufacturing site, which diverts time and resources from more urgent inspections as well as other regulatory priorities.
Many industries such as banking and telecommunication operate seamlessly across national borders. Todays medicines are global commodities, so the regulation of medicines should function just as seamlessly, said Alastair Wood, emeritus professor of medicine and pharmacology at Vanderbilt University, who chaired the committee that wrote the report. Regulatory authorities need to be able to use the best science, the best expertise, and the best resources to make informed decisions to protect the health of millions of people.
Improve the Design of Mutual Recognition Agreements The report outlines a stakeholder-driven strategy to improve cooperation and collaboration among regulators, which includes:
Respond to Evolving Science and Technology Formal MRAs are not currently agile enough to respond to rapid changes in science and technology, or to public health emergencies. Regulatory authorities should consider potential areas for scope exploration of both formal recognition agreements such as MRAs and less formal reliance arrangements (e.g., collaborative activities) including: guidelines for reliable and high-quality laboratory data, guidance for studies involving human subjects, and guidance for the manufacturing, production, and distribution of medicines.
Expand the Scope of the European Union (EU)-U.S. MRA Currently, the EU-U.S. MRA only applies to manufacturing site inspections. The EU-U.S. MRA should be expanded to include reliance in additional areas and for a broader range of medicine types, the report recommends. In addition, the provisions in the MRA for inspections that the FDA and European Medicines Agency conduct outside of the U.S. and EU (third country inspections) should be implemented immediately.
Formally Evaluate the Public Health Impacts of Reliance and Recognition Arrangements Most reliance and recognition arrangements do not explicitly call for evaluation of public health benefits, and there is a lack of data on their successes and challenges. Regulatory authorities should create a results framework with clear indicators, metrics, and processes for monitoring and evaluating recognition and reliance arrangements, the report recommends. This would increase understanding of their public health benefits, and enable benefit-risk and cost-benefit analysis over time.
The study undertaken by the Committee on Mutual Recognition Agreements and Reliance in the Regulation of Medicines was sponsored by the U.S. Food and Drug Administrations Office of Global Policy and Strategy.
The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide independent, objective analysis and advice to the nation to solve complex problems and inform public policy decisions related to science, technology, and medicine. They operate under an 1863 congressional charter to the National Academy of Sciences, signed by President Lincoln.
Resources:RecommendationsReport Highlights
Contact:Stephanie Miceli, Media Relations OfficerOffice of News and Public Information202-334-2138; e-mail news@nas.edu
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The Medicine Plant That Could Have Changed the World. – The National Interest Online
Posted: at 5:46 pm
Growing up in Tanzania, I knew that fruit trees were useful. Climbing a mango tree to pick a fruit was a common thing to do when I was hungry, even though at times there were unintended consequences. My failure to resist consuming unripened fruit, for example, caused my stomach to hurt. With such incidents becoming frequent, it was helpful to learn from my mother that consuming the leaves of a particular plant helped alleviate my stomach pain.
This lesson helped me appreciate the medicinal value of plants. However, I also witnessed my family and neighboring farmers clearing the land by slashing and burning unwanted trees and shrubs, seemingly unaware of their medicinal value, to create space for food crops.
But this lack of appreciation for the medicinal value of plants extends beyond my childhood community. As fires continue to burn in the Amazon and land is cleared for agriculture, most of the concerns have focused on the drop in global oxygen production if swaths of the forests disappear. But Im also worried about the loss of potential medicines that are plentiful in forests and have not yet been discovered. Plants and humans also share many genes, so it may be possible to test various medicines in plants, providing a new strategy for drug testing.
As a plant physiologist, I am interested in plant biodiversity because of the potential to develop more resilient and nutritious crops. I am also interested in plant biodiversity because of its contribution to human health. About 80% of the world population relies on compounds derived from plants for medicines to treat various ailments, such as malaria and cancer, and to suppress pain.
Future medicines may come from plants
One of the greatest challenges in fighting diseases is the emergence of drug resistance that renders treatment ineffective. Physicians have observed drug resistance in the fight against malaria, cancer, tuberculosis and fungal infections. It is likely that drug resistance will emerge with other diseases, forcing researchers to find new medicines.
Plants are a rich source of new and diverse compounds that may prove to have medicinal properties or serve as building blocks for new drugs. And, as tropical rainforests are the largest reservoir of diverse species of plants, preserving biodiversity in tropical forests is important to ensure the supply of medicines of the future.
Plants and new cholesterol-lowering medicines
The goal of my own research is to understand how plants control the production of biochemical compounds called sterols. Humans produce one sterol, called cholesterol, which has functions including formation of testosterone and progesterone - hormones essential for normal body function. By contrast, plants produce a diverse array of sterols, including sitosterol, stigmasterol, campesterol, and cholesterol. These sterols are used for plant growth and defense against stress but also serve as precursors to medicinal compounds such as those found in the Indian Ayurvedic medicinal plant, ashwagandha.
Humans produce cholesterol through a string of genes, and some of these genes produce proteins that are the target of medicines for treating high cholesterol. Plants also use this collection of genes to make their sterols. In fact, the sterol production systems in plants and humans are so similar that medicines used to treat high cholesterol in people also block sterol production in plant cells.
I am fascinated by the similarities between how humans and plants manufacture sterols, because identifying new medicines that block sterol production in plants might lead to medicines to treat high cholesterol in humans.
New medicines for chronic and pandemic diseases
An example of a gene with medical implications that is present in both plants and humans is NPC1, which controls the transport of cholesterol. However, the protein made by the NPC1 gene is also the doorway through which the Ebola virus infects cells. Since plants contain NPC1 genes, they represent potential systems for developing and testing new medicines to block Ebola.
This will involve identifying new chemical compounds that interfere with plant NPC1. This can be done by extracting chemical compounds from plants and testing whether they can effectively prevent the Ebola virus from infecting cells.
There are many conditions that might benefit from plant research, including high cholesterol, cancer and even infectious diseases such as Ebola, all of which have significant global impact. To treat high cholesterol, medicines called statins are used. Statins may also help to fight cancer. However, not all patients tolerate statins, which means that alternative therapies must be developed.
Tropical rainforests are medicine reservoirs
The need for new medicines to combat heart disease and cancer is dire. A rich and diverse source of chemicals can be found in natural plant products. With knowledge of genes and enzymes that make medicinal compounds in native plant species, scientists can apply genetic engineering approaches to increase their production in a sustainable manner.
Tropical rainforests house vast biodiversity of plants, but this diversity faces significant threat from human activity.
To help students in my genetics and biotechnology class appreciate the value of plants in medical research, I refer to findings from my research on plant sterols. My goal is to help them recognize that many cellular processes are similar between plants and humans. My hope is that, by learning that plants and animals share similar genes and metabolic pathways with health implications, my students will value plants as a source of medicines and become advocates for preservation of plant biodiversity.
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Walter Suza, Adjunct Assistant Professor of Agronomy, Iowa State University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Consumer DNA Testing May Be the Biggest Health Scam of the Decade – Gizmodo
Posted: at 5:46 pm
At the start of this decade, the federal government called out consumer DNA testing as a burgeoning scam industry. Little did we know how it would explode in popularity.
In 2010, the U.S. Government Accountability Office (GAO) published an investigative report that bashed consumer DNA test companies for misleading the public. It accused them of deceptively claiming their products could predict the odds of developing more than a dozen medical conditions; some even went as far to offer equally dubious dietary supplements. The report had followed a similar lambasting of the industry by the GAO in 2006.
Also in 2010, the FDA publicly warned 23andMe and other companies that genetic health tests were considered medical devices and needed to be cleared by the FDA before they could be sold to the public. Three years later, following a lack of response from 23andMe, the agency took the harsh step of temporarily banning 23andMe from selling its health-related tests at all.
Despite these hurdles, the DNA testing industry has nonetheless exploded. According to a report by MIT Technology Review this February, more than 26 million people have had their DNA tested by the biggest names in the industry, with AncestryDNA, 23andMe, and MyHeritage being the top three.
Consumer DNA testing is undoubtedly now mainstreambut its not much less scammy than it was when the decade started.
The industry has existed since the late 1990s. But in 2007, the new kid on the block, 23andMe, became the first company to offer a particular kind of at-home DNA test that was cheap, easy to use, and promised to track back your origins further back than ever before.
23andMes testsand eventually those of its competitorssearch for and analyze the most common genetic variations, called single nucleotide polymorphisms (SNPs), in our autosomal DNA, the 22 of 23 pairs of chromosomes not used to determine sex. For as little as $99 and a spit sample, these SNP-based tests are advertised to determine a persons ancestry or genetic health risks. But much of this realm of consumer DNA testing, as the GAO report showed, can uncharitably be described as complete bullshit.
The crux of the problem is that our genetics are only a piece of the puzzle that influences our health. Sure, you can sometimes point to a specific gene mutation that always makes someone sick in a specific way if they carry it. But much more often, its a complex, barely understood mix of gene variants that predispose us to develop cancer or heart diseaseand that risk can be amplified or muted by our environment (including the crucial months we spend in the womb).
In the earliest days, companies didnt much care for this complexity, using weak evidence to make sweeping health claims about which genes ought to make you more of a fish eater or develop diabetes.
Following the FDAs ban in 2013, 23andMe spent the next two years devising genetic health tests that wouldnt overpromise. In 2015, it was allowed to sell tests that told people if they carried a recessive mutation for genetic conditions like Bloom syndrome and sickle-cell disease. A positive test meant their children would have a 25 percent chance of having the condition if both parents were carriers. Two years later, it became the first company with FDA-approved tests that were allowed to tell people about their risk of developing one of 10 diseases or conditions, such as late-onset Alzheimers or celiac disease.
23andMes return to the health side of things wasnt the only fuse that lit a fire under the consumer DNA industrythe tens of millions in annual advertising now being spent by companies like MyAncestry certainly helped, too. But regardless, the FDAs approval of these tests signaled a new opening in the industry. And unsurprisingly, the industry as a whole has ballooned, as has the glut of scammy services on offer.
Many of these companies now steer clear of making blanket health claims, but it doesnt make them any less laughable. Your DNA results can apparently tell you whether youve found your romantic match, how to be good at soccer, and, like a decade ago, how to find the perfect diet and avoid bloating. Just dont pay attention to the studies showing that theres no consistent link between genes seemingly tied to our nutrition and any actual diet-related conditions.
Its not only the tests vaguely connected to our health that are the problem. As Gizmodo once illustrated, even relying on these DNA tests to figure out your ancestry is a dicey proposition. At best, youre roughly estimating where your recent ancestors lived, but that estimate can vary widely depending on which company does the testing, thanks to the different algorithms they use. And the farther away your lineage is from Europe, the less accurate these tests will be for you, thanks to the fact that the algorithmsas well as the research linking genes to our healthare largely based on the DNA of white Americans and Europeans.
Health and ancestry aside, sharing your DNA with the outside world can have unintended consequences. Law enforcement agencies are now using genealogy databases to solve criminal cases, by connecting anonymous crime scene DNA to DNA submitted to these family tree companies, working backward through distant relatives to identify their suspect. And while some people may be fine with this genetic sleuthing, there are no clear rules on how this data can be used by law enforcementtheres merely the promise by private companies that they will share responsibly. This November, police in Florida obtained a warrant to search through a third-party genealogy database, months after the service had enforced a new opt-in policy meant to let users decide if they wanted their data to be searchable by police in these cases.
At a certain point, it wont even matter whether youve decided to share your DNA. A study last October estimated that once enough peoples DNA is in a databasea scant 2 to 3 percent of any given populationanyone could conceivably track the identity of every person in that population using the same techniques genetic detectives are using now. And researchers have already demonstrated how less scrupulous forces, including hackers, could actively manipulate these databases.
None of this is meant to diminish the real potential of genetics as a field of research and medicine, nor the progress that has been made over the past decade.
Companies like 23andMe rely on detecting thousands of genetic markers still only a tiny slice of our DNA. But the technology that allows a persons entire genome to be sequenced has vastly improved, scaling down its costs and upkeep over the past decade. These techniques can scan a persons whole genome as well as the smaller part of the genome that codes for the proteins our bodys cells make, called the exome.
In 2010, for instance, the company Illumina initially offered its whole genome sequencing at $50,000 a person; this year, Veritas dropped the price of its service to only $600 and says it may soon charge as little as $100.
These innovations have led to large-scale research projects that collect genetic data from hundreds of thousands of people at once. Scientists can scour through these large datasets to find new links between our genes, traits, and medical conditions. This research has helped us better understand longstanding questions about our biology and health. Someday soon, genetic sequencing may also help us optimize the existing medical treatments people get, particularly for conditions like cancer.
Right now, though, its still up in the air how useful this info dump really is to the average person looking to stay healthy.
In March, 23andMe debuted (or more accurately, reintroduced) a service that tells people about their genetic risk of type 2 diabetes. Unlike the tests approved by the FDA, it relies on whats known as a polygenic risk score. This adds up the very small contribution of many genetic markers to a particular condition, which combined might be enough to nudge your overall risk upwards.
The trouble is that these markers have little to do with why you get type 2 diabetesyour age or weight play a much bigger role. And even if the test does consider you genetically unlucky (an average risk difference of 5 percent from a typical person), the advice youll get is the same that anyone hoping for a long, healthy life would get: eat more vegetables and exercise more. This test, as well as many of those offered by the hundreds of big and small DNA testing companies on the market, illustrates the uncertainty of personalized consumer genetics.
The bet that companies like 23andMe are making is that they can untangle this mess and translate their results back to people in a way that wont cross the line into deceptive marketing while still convincing their customers they truly matter. Other companies have teamed up with outside labs and doctors to look over customers genes and have hired genetic counselors to go over their results, which might place them on safer legal and medical ground. But it still raises the question of whether people will benefit from the information they get. And because our knowledge of the relationship between genes and health is constantly changing, its very much possible the DNA test you take in 2020 will tell you a totally different story by 2030.
Given how popular at-home DNA testing has become, theres really no sealing the genie back in the bottle. So if you want to get your genetic horoscope read this holiday, dont let me stop you. But its a big decision you should sleep on. After all, once your DNA is out there, theres no going back.
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Genetically Modified Babies? Possible Within the Next Two Years, Scientists Claim – Nature World News
Posted: at 5:46 pm
Nov 21, 2019 08:42 AM EST
(Photo : Josh Reddekopp, Unsplash)Genetic modification is expected to free or at least delay hereditary diseases.
When you heard of the word GMO, the first thing that you will probably think of is food items you find at the grocery store that was modified by scientists to change their appearance or just improved their overall qualities.
However, a recent scientific paper claimed that the same gene-altering method might be able to apply to human embryos ethically within two years.
According to bioethicist Kevin Smith, this method will give hope to parents who want their children to be free from genetically-transmitted diseases.
He also said that from a "utilitarian standpoint", gene-altering is the only "conceivable" way of dealing with these conditions. Some conditions he mentioned are cancer, cardiovascular diseases, and dementia.
And since this practice is generally opposed by the public due to the fear of abusing it, Smith suggested simply delaying the conditions, which can still extend the disease-free lifespan of future individuals.
Yet he still believed that this method would be "ethically justified" within two years, especially since current gene-editing technologies present low risks even if used on human embryos.
The study was criticized by other health experts, mostly pointing out the insufficiency of experimentation to prove its safety.
Joyce Harper of the University College London (UCL) Institute for Women's Health said that while gene editing has used potential, she also wants public debate and lawmakers' interventions to ensure its ethicality.
The director of Progress Educational Trust (PET), Sarah Norcross, said that we should have learned the controversial genome-edited babies introduced by a Chinese scientist last year. She also mentioned the need for "higher scientific and ethical standards" if this practice will strive.
The study was published last week in the journal Bioethics.
Last year, Chinese scientist He Jiankui announced in Youtube that he had successfully created the first genetically modified babies -- twin girls that are immune to HIV -- using the gene-editing tool CRISPR-Cas9.
This resulted in an international outcry. Feng Zhang, one of the inventors of CRISPR, told CNN that nobody, including the scientific community, has expected someone to use the tool on humans. Other scientists were refusing to do this since the technology is still not quite complete and the possible genetic complications on humans in their later years are still unknown.
The Chinese authorities called He, who is also a professor at the Southern University of Science and Technology in Shenzhen, to halt his activities. Fellow Chinese scientists condemn him and called him an insult to the biochemical research in China.
Because of He's practice, the country was also scrutinized due to its previous reputation of favoring innovation too much even if it means setting aside ethical questions.
The Journal Nature Medicine recently published a study that claims genetically modifying embryos would result in a shorter lifespan.
Despite the massive backlash, He defended his project at the Second International Summit on Human Genome Editing held at Hongkong in November last year. According to him, this method had given hope to the parents of the twins, whose father is infected with HIV.
He also announced that he is working on the third genetically modified baby but no further information was given.
READ: It's in the Genes: Study Discovers 79 Forms of Genetic Obesity, More Than Previously Thought
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