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Category Archives: Transhuman News
Gene linked to Alzheimers disease plays indirect role in risk for… – ScienceBlog.com
Posted: November 23, 2019 at 12:02 pm
Delirium is the most common post-surgical complication in older adults. Marked by acute temporary confusion, disorientation and/or agitation, it strikes as many as half of adults over 65 who undergo high-risk procedures such as cardiac surgery and hip replacements.
Postoperative delirium is also tightly linked to Alzheimers disease. Although each can occur independently, Alzheimers is a leading risk factor for delirium, and an episode of delirium puts patients at increased risk for cognitive decline and Alzheimers.
However, the physiological mechanisms that link delirium and Alzheimers disease remain largely unknown.
Get more HMS news here
Now, in a paper published Nov. 22 in Alzheimers & Dementia: The Journal of the Alzheimers Association, researchers at Harvard Medical School and Beth Israel Deaconess Medical Center shed light on a genetic risk factor for Alzheimers disease that may indirectly influence patients risk of postoperative delirium.
In a study of older adults without dementia undergoing major noncardiac surgery, researchers observed that patients carrying a specific variant of a gene appeared to be much more vulnerable to delirium under certain conditions than people without the variant.
The teams findings could open the door to future interventions to prevent or mitigate postoperative delirium in at-risk patients.
Our findings confirmed our hypothesis that patients risk of postoperative delirium differs by genetic predisposition, said Sarinnapha Vasunilashorn, assistant professor of medicine at HMS and Beth Israel Deaconess and first author of the study. We observed a strong and significant association between high postoperative inflammation and delirium incidence, duration and severity among patients carrying a variant of the gene considered to be risky, while the association was weaker and nonsignificant among noncarriers.
Vasunilashorn and colleagues focused on a gene called APOE, short for apolipoprotein E. The risky version of the gene, notated as APOE 4, is the strongest known genetic risk factor for late-onset Alzheimers disease and a widely studied genetic risk marker for delirium.
While recent studies have shown no direct relationship between APOE 4 and delirium, Vasunilashorns team hypothesized that the gene variant might indirectly influence risk of delirium by modifying the bodys response to inflammationpart of the immune systems natural defense systemindicated by the presence of an inflammatory marker in the blood called C-reactive protein, or CRP.
Using data from the Successful Aging after Elective Surgery (SAGES) study, an ongoing prospective cohort study investigating risk factors and long-term outcomes of delirium, the scientists looked at the incidence, severity and duration of delirium in 560 patients who were at least 70 years old and who underwent major noncardiac surgeries under general or spinal anesthesia. Patients were monitored for delirium, assessed by daily cognitive assessments of attention, memory and orientation throughout their hospital stay.
Analyzing data from patients blood drawn before surgery, immediately after surgery, two days after and one month after revealed that, among carriers of the APOE 4 gene variant, patients with high levels of inflammation had an increased risk of postoperative delirium. However, among noncarriers of the APOE 4 gene variant, the scientists found no such association.
Our findings suggest that APOE 4 may be an indicator of brain vulnerability, said Vasunilashorn. This work may inform the targeting of future interventions, such as anti-inflammatory treatments, for prevention of postoperative delirium and its associated adverse long-term cognitive outcomes in patients with this genetic susceptibility.
Edward Marcantonio, professor of medicine at HMS and Beth Israel Deaconess, is senior author of the study.
This work was supported by the National Institute of Aging of the National Institutes of Health (grants K01AG057836, R03AG061582, P01AG031720, R24AG054259, K07AG041835, R21AG057955, R01AG041274, R21AG048600, R01AG051658 and K24AG035075); the Charles A. King Trust Postdoctoral Research Fellowship Program; Bank of America, N.A., Co-Trustee, and the Alzheimers Association (AARF-18-560786).
Adapted from a Beth Israel Deaconess news release.
Image: kemalbas/Getty Images
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Gene linked to Alzheimers disease plays indirect role in risk for... - ScienceBlog.com
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A Reflection On BTD And RMAT Designations – Pink Sheet
Posted: at 12:02 pm
The continuing interest in cell and gene therapies is reflected by the 800+ active investigational new drug (IND) applications within the field that are on file with the US Food and Drug Administration (FDA).1 This trend is only set to increase, with the FDA foreseeing the approval of 1020 cell and gene therapy (CGT) products per year by 2025.2
To increase the number of therapeutic options for treatment of conditions for which there is currently no cure, there are two FDA expedited pathways: the Regenerative Medicine Advanced Therapy (RMAT) designation and the Breakthrough Therapy designation (BTD). Both are well suited to the development of cell and gene therapies. This article reflects on the usage of these designations and, throughout, Keith Webber, Vice President, Biotechnology at Lachman Consultant Services, Inc., provides insights and advice regarding the two accelerated pathways for cell and gene therapies.
Being the earlier of the two designations (2012), BTD holds the majority of product approvals. This pathway was followed in 2017 by the RMAT, which has a particular focus on cell and gene therapies, tissue engineering products, and human cell or tissue products. This differentiates it from the BTD, which is also applicable to other types of therapies if they address serious or life-threatening conditions. Table 1 provides an over-view of the number of requests for each designation, as well as the success rate across 2019.
Despite the number of BTD requests exceeding quadruple the number of RMAT applications, the success rates are comparable, at around 3540%. This has also been the case for cumulative data that show all submissions since each designation was introduced (refer to this 2018 Pink Sheet guide for cumulative information, plus further trends including therapy areas and sponsor types). However, there are certain differences in evidentiary criteria for applying for both pathways that may affect decision-making regarding which designation to apply for. With the BTD, sponsors must provide evidence that the treatment is likely to be a substantial safety or efficacy improvement over existing therapies, which is not the case for RMAT.5 As a result, if a product candidate is eligible, Webber notes that it could be beneficial to gain both designations as, if you can apply for both, you can choose the most advantageous if you receive both, so it opens up more opportunities.
Inevitably, there are certain challenges associated with applying for either designation. According to Webber, one factor to be mindful of: Often the clinical development is more advanced than the chemistry, manufacturing and controls (CMC) development. The CMC and product development can be a rate-limiting component for a Biologics License Application (BLA) submission or approval. So that is something to keep in mind. You dont want this to hold you back as you move through development. Ensuring all elements of the research and development process are aligned is therefore an important factor for boosting chances of rapid product approval.
Post-approval requirements can be another consideration when determining which pathway is most suitable. For an accelerated approval under BTD, there is a requirement to perform a post-approval confirmatory study when the approval has been based on a smaller data set or surrogate endpoints. The post-approval requirements for the RMAT are not as rigid; Webber notes that the accelerated approval may allow the use of historical controls, retrospective studies, monitoring data or real-world evidence there are more opportunities for that confirmatory evaluation. This may be because the BTD is for all products, including traditional pharmaceuticals, whereas RMAT is only for the more complex biological products. As such, RMAT products are often times more challenging to design clinical studies for.
The topic of post-approval and surrogate endpoints can raise concern around treatments being ineffective, or possibly toxic, upon being marketed.6 In terms of advice, Webber said, Communicate with the FDA early and often when designing your trials or planning approval. There is an FDA guidance document, called Interacting with the FDA on Complex and Innovative Trial Designs, which provides sound advice for developing successful clinical protocols. The recommendation is to get both FDA input and acceptance as early as possible on trial design. To support these critical interactions, the FDA has set a goal of recruiting 50 new clinical reviewers for CGT products.7
The recent development of Medicaid expanding coverage for products receiving accelerated approvals signifies the interest and investment in cell and gene therapies.8 This is in tandem with a growing trend of larger companies being increasingly keen to own gene therapy technologies rather than partnering. Historically, gene therapies have been spearheaded by small biotechnology companies (typically in partnership with larger pharmaceutical firms). In fact, 90% of gene therapy development is by companies with fewer than 500 employees.9 From his experience in carrying out due diligence for larger organizations interested in investing or acquiring smaller biotechnology companies, Webber noted: Be vigilant in your due diligence assessments when considering buying or investing into a company. You should watch out for gaps in product development. For example, there may be deficiencies in the establishment of the master cell bank or working cell banks.
Look out for poorly characterized components in the product and qualification of materials. In addition, watch out for any lack of standardization, which can create issues further on in the process. Webber explains that There may be a lot of variability in how the manufacturing processes are performed during development and that can be a challenge in terms of establishing what is the consistent product thats coming out of that manufacturing process. In many cases, the product is the process. So if the processes are changing continually, and the product is difficult to fully characterize (as often the RMAT products are), you can have considerable uncertainty with regard to the interpretation of any preliminary clinical data.
Data integrity can also be an issue, for which Webber suggests paying close attention to the ALCOA principles (Attributable, Legible, Contemporaneous, Original and Accurate). Those principles should be in place, and if they arent it can be challenging to be reliant on that data for presentation to the FDA during inspection.
Webber indicates that manufacturing is a final area of the process that can come under scrutiny: Sometimes there are manufacturing changes during development that have not been qualified. So, the company makes changes where they havent really evaluated the impact (of those changes) during development of the manufacturing process.
* REQUESTS THAT ARE STILL PENDING A DECISION ARE INCLUDED IN THE TOTAL REQUESTS RECEIVED COLUMN.NUMBERS ARE FOR US FEDERAL FISCAL YEAR 2019, ENDED 30 SEPTEMBER 2019.
The direction of growth in cell and gene therapies is moving further toward personalized medicines. At this point, it is difficult to predict how the regulatory land-scape will accommodate these advancements. One of the largest challenges to anticipate may be in assessing clinical outcomes, where variances could be due to patient-to-patient differences or product-to-product differences. It might be necessary to develop methods to assess the in vivo product performance, for example, gene incorporation and gene expression, in addition to the assessment of clinical outcome, to further under-stand the relationship between clinical performance and product performance in vivo. Webber continued, explaining that the FDAs Center for Biologics Evaluation and Research (CBER) has released many new guidances regarding CGT, covering everything from certain therapeutic areas such as hemophilia to evaluations of devices used in regenerative medicine.
Given that the cell and gene therapy accelerated pathways are relatively new, and with the stance of Medicaid reimbursing such products, applications for accelerated approval pathways are set to skyrocket. The possibilities that cell and gene therapies may unveil could be truly profound. That being said, approval for CGT is undoubtedly going to become more complex with the advancement of personalized medicine, and this could create further complications when conducting studies and assessing clinical outcomes (due to individual variance).
A closing remark from Webber: The FDA has a great interest in bringing new and effective treatments to patients, so I encourage sponsors to take advantage of this willingness, to meet with the FDA early and during product and clinical development phases. Also, work with consultants as needed to get guidance on preparing submissions and product development as you move forward.
SOURCES
https://www.fda.gov/media/95286/download
https://www.medicaidandthelaw.com/tag/gene-therapies/
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A Reflection On BTD And RMAT Designations - Pink Sheet
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Nature vs Nurture: What’s Fueling the Obesity Epidemic? – Medscape
Posted: at 12:02 pm
Dr Sadaf Farooqi
BRIGHTON, UK The obesity epidemic is not simply the result of changes in the lived environment but a complex interplay between genes and surroundings that has driven people who would have been genetically susceptible but remained thin in previous eras to become obese, says one expert.
This was the argument put forward as part of a debate on whether an individual's body weight is determined by "nature or nurture" at the recent Society for Endocrinology BES Conference 2019 in Brighton, UK.
Before the debate began, Rob Semple, MD, University of Edinburgh, UK, introduced the speakers and polled the audience on their "baseline" views onthe statement: "This house believes that nature not nurture determines our body weight."
The response was 36% "for" the statement (ie, nature) and 64% "against,"which Semple noted suggested that the first speaker, Sadaf Farooqi, MBChB, PhD, "will have her work cut out" to convince the audience that nature is the main driver of obesity.
Farooqui is professor of metabolism and medicine at the University of Cambridge, UK, and was the winner of the 2019 American Diabetes Association Outstanding Scientific Achievement Award.
Farooqi's adversary in the debate was John Wilding, DM, of the University of Liverpool, UK, who Semple described as "similarly formidable."
Farooqi began by saying that the question before the audience is "fundamentally important," and noted that there is plenty of evidence to suggest there is a biological system for regulating body weight.
Experiments have shown that animals and humans maintain a set point for weight that they return to after periods of limited food intake, regardless of how much weight they lose.
Initially, the hypothalamus was found to play a key role in weight regulation, but it was the discovery of leptin that allowed the whole system, with its links to adipose tissue, the pancreas, and the intestines, to be elucidated, she explained.
Work with children then revealed the influence of genetic factors on the body weight "set point."
Identical twins reared apart were found to have a very similar body weight, and adoptive children were shown to have a similar weight to their biologic, rather than adoptive, parents.
Tying these observations to individual or small numbers of genetic variants has, however, proven difficult, beyond the known variants associated with thinness and the rare variants in 15 genes linked to severe obesity.
That is, Farooqi said, until the publication of US research earlier this year testing a polygenic risk predictor involving 2.1 million common variants in more than 300,000 individuals.
The research showed that, across polygenic score deciles, there was a 13-kg gradient in weight and a 25-fold gradient in the risk of severe obesity.
Moreover, another 2019 study, this time by Farooqi's team, revealed some loss of function variants in the melanocortin 4 receptor gene are linked to an increased risk of obesity, type 2 diabetes, and coronary artery disease, and some gain in function variants are linked to a lower risk of obesity and cardiometabolic disorders.
Farooqi believes the reason there is an obesity epidemic is that the physiological system for regulating weight "evolved to stop us starving" but is now faced with "an abundance of food."
The impact of this is all the greater because we live in a "complex food environment," with high sugar and high fat foods that are seen as "very rewarding," as demonstrated on brain scans of people shown pictures of such foods.
Individuals also engage in stress-related eating, which is played out via neural circuits linking the hypothalamus to the limbic system.
She characterized such eating as a "biologically appropriate thing to do because it gives you a rewarding, pleasurable feeling."
She said that, together, this underlines that the "biology of appetite" is a mixture of both innate and learned behaviors.
Farooqi concluded: "I hope I've made the case for you that there is clear, strong, compelling evidence" that weight is regulated by a homeostatic system centered on the hypothalamus, and genetic disorders, tumors, surgery, radiotherapy, and medications can all "perturb" weight regulation.
"In some people, that promotes obesity, in some people it protects them against obesity," she said.
Dr John Wilding
Taking to the podium, Wilding proceeded to present the case for the notion that body weight is determined "by nurture."
He pointed to data from the World Obesity Federation on adult obesity showing that, between the 1960s and 1990s, the prevalence of obesity topped more than 15% in only a few developed countries and no developing nations.
But from 2000 onwards, the situation has completely reversed. At least 15% of the population is obese in most developed countries, rising to over 25% in the United States, Canada, Australia, and the UK, among others. The prevalence of obesity is also rising rapidly in many middle-income countries.
Yet, Wilding pointed out, humanity cannot have evolved genetically to a sufficient extent over that period to account for the change.
He turned to the UK Government's obesity system map, which is a visual representation of the different factors that influence obesity levels.
Although it places physiological energy balance at the heart of the map, and a large part of that is devoted to biologic processes, Wilding highlighted that the visual also places a great degree of emphasis on food production and consumption, societal influences, individual psychology and movement, and the "activity environment."
He also showed data suggesting it is not so much energy and fat intake that is associated with obesity trends as the increase in the number of cars per household and hours spent watching television.
For example, it is estimated that, compared with the 1950s, the average adult now walks, on average, a marathon (approximately 26 miles) less per week, he said.
The Cuban economic crisis of the 1990s also provides an illuminating example, Wilding added.
The sudden end of Soviet subsidies to Cuba led to food shortages, the loss of public and private transport, and the importof 1.5 million bicycles from China.
The subsequent drop in the prevalence of obesity was associated with a reduction in the incidence of diabetes and diabetes-related mortality, with all three increasing substantially once food and transport levels were restored.
Taking a more recent example, Wilding showed longitudinal findings from the HUNT study, which involved almost 119,000 individuals with repeated body mass index (BMI) measurements from 1963, and over 67,000 who were tested for 96 known obesity genes.
The HUNT authors concluded that, although "genetically predisposed people are at greater risk for higher BMI and that genetic predisposition interacts with the obesogenic environment resulting in higher BMI...BMI has increased for both genetically predisposed and nonpredisposed people, implying that the environment remains the main contributor."
Wilding said that, taken together, obesity is "common and increasing almost everywhere," and that the epidemic "is driven by societal change," despite the underlying biology determining an individual's susceptibility.
He ended his pitch to much laughter with a quote by Farooqi from a 2014 review that supports his argument: "Evidence clearly shows that both increases in energy intake and reductions in energy expenditure during physical activity have driven increases in the mean BMI seen in many countries over the past 30years."
Both speakers were then invited back to the podium, allowing Farooqi to respond that, although she did indeed pen that statement in a 2014 review, if one were to look "carefully," the article discussed the last 30 years, and indeed, "our genes haven't changed in that time, but the environment has."
"We agree on that point, and hence my quote," she said, "but what our environment has done is it has unmasked the genetic susceptibility of some individuals, so what we see when we look at the pattern of BMI in the population is that the mean BMI has increased...but also the proportion of people with severe obesity has increased."
She clarified that what this suggests is that, within any population, there are some people who are genetically more susceptible to obesity, so some of those who may not have been obese 30 years ago now are because of the environment.
"It is the environment acting on genetic susceptibility that is contributing to the distribution of BMI," she emphasized.
Wilding again pointed to the HUNT study, which showed that, even in individuals with "thin genes," there has been a rise in mean BMI.
Farooqi said this, in fact, underlines a limitation of that study, which is they only used 96 well-known genetic variants associated with obesity, but the polygenic risk study she highlighted earlier used 2.1 million genetic variants.
Consequently, data from the HUNT study "captures some of the variation but not all," she stressed.
The debate continued, with questions from the floor covering many aspects of obesity.
The final question was directed at Farooqi: "What proportion of somebody's weight is considered to be genetic...as opposed to the nurtured weight?"
She replied this is a "hugely important" question, because "if we don't recognize that theres a biological role for the regulation of weight, how on earth can politicians, with their somewhat different capacity for taking on new information, do that?"
The "evidence suggests around 40% of a person's weight is influenced by genetic factors," she said.
"In some people it's higher, where there are penetrant genes having an effect, in other people it's about 40% with a combination of genes which, added together, influence their risk of either gaining weight or staying thin."
In response, Wilding was keen to stress: "No matter which side of the argument you're on, the point is that this is not the individual's fault."
"It's either a response to their environment...or it's something that they've inherited and don't have individual control over," he noted.
"Sadaf [Farooqi] said it herself, 40% of our body weight is genetic, that means that 60% is environmental, and I rest my case," Wilding said.
However, that did not hold sway with the audience, who, when they voted again at the end of the debate, indicated they had changed their minds: 53% agreed with the statement that nature, not nurture, determines body weight, and 47% disagreed.
A win for the lady, it would seem.
Society for Endocrinology BES 2019. Presented November 11, 2019.
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Nature vs Nurture: What's Fueling the Obesity Epidemic? - Medscape
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Sniffing Out Cancer in Canines And Humans, Too – NC State News
Posted: at 12:02 pm
Matthew Breen, a professor of genomics at NCState, says his 25-year career has roots in childhood heartbreak.
When I was young, my family had two dogs die from cancer and there was very little we could do to help them, says Breen. There were great strides being made with human cancer research, so why were we unable to help our animal companions more?
We are committed to making that change happen at NCState, he adds.
Today, the internationally recognized researcher specializes in molecular cytogenetics: the study of the structure and function of cells and chromosomes. His work in the College of Veterinary Medicine is helping our pets live longer, healthier lives and unlocking new insights about human cancers along the way.
Since joining NCStates faculty in 2002, Breen has focused on exploring the genetics and genomics of animal diseases, including how they initiate and respond to treatment.
He was a member of the team that sequenced the canine genome 14 years ago. The project sparked a new area of focus in his field: comparing the canine and human genomes to accelerate discoveries for both.
Humans and their furry friends actually share a very similar genetic makeup. And they share certain types of cancers, too. Many cancers diagnosed in humans and dogs have a similar pathology and clinical presentation, says Breen.
But when it comes to canines, its often easier to pinpoint the genetic abnormalities that lead to those cancers. This is especially the case for purebreds. Dogs of the same breed have less genetic variation among them than humans or mixed-breed dogs, making them an ideal genetic model.
Now, Breens lab works extensively in the area and hes become a pioneer in comparative oncology.
By working with human and animal cancers side by side, we are able to find shared features that may help identify the drivers of these cancers and provide opportunities to highlight targets for new therapies, says Breen.
Take, for example, Breens work with the BRAF gene.
Six years ago, his team discovered that a single mutation in the gene was found in 85% of dogs with transitional cell carcinoma (TCC) also called urothelial carcinoma (UC) which is the most common form of bladder cancer in canines. More than 80,000 dogs in the United States will be affected this year alone.
This particular BRAF mutation was already known to exist in some human cancers, but Breens discovery helped unlock its significance for both species. It also revealed an opportunity to create a much-needed tool to aid diagnosis.
By working with human and animal cancers side by side, we are able to find shared features.
In most cases, canine bladder cancer isnt diagnosed until it has reached an advanced stage. Thats because the cancer shares many clinical signs with other, more common urinary tract conditions.
Treatments for the common alternatives may alleviate symptoms temporarily, but they mask the larger problem and buy the cancer more time to progress. In fact, upon diagnosis, more than half of canine bladder cancer cases have already spread.
Identifying the BRAF mutation as a genetic signature of canine bladder cancer was a powerful insight. From there, Breens team began developing a molecular diagnostics test that could identify the mutation and detect the cancer earlier than ever.
That molecular test called CADET BRAF was developed in Breens research laboratory in 2014. Using a urine sample, the system detects cells that possess the BRAF mutation and can monitor changes in the number of mutated cells being shed during treatment of canine TCC and UC.
CADET BRAF represents the worlds first liquid biopsy for the detection of cancer in veterinary medicine, says Breen.
It offers several improvements over current alternatives. Requiring only a simple free-catch urine sample, CADET BRAF is the only non-invasive approach. Other methods often involve costly procedures, such as sedation or anesthesia, that carry additional risks.
The test can also detect bladder cancer in the early stages of the disease, potentially leading to improved outcomes.
CADET BRAF represents the worlds first liquid biopsy for the detection of cancer in veterinary medicine.
We can detect the cancer in dogs that have already presented with clinical signs and avoid repeated attempts to treat solely the signs, says Breen. That allows more time for the veterinarian and owner to develop a plan to treat the root cause. In addition, we have been able to detect the presence of very early disease, several months before the dog has any clinical signs.
Now we have to determine how to manage these preclinical patients, and that is part of ongoing work by our team at NCStates College of Veterinary Medicine, he adds.
The test is also dependable. After rigorous validation of thousands of dogs, Breen says hes found that the presence of the BRAF mutation in canine urine is a highly reliable indicator of the presence of TCC/UC. Weve shown the BRAF mutation isnt found in the urine of healthy dogs or dogs that have other common conditions such as bladder polyps, inflammation or chronic cystitis, he says.
In the two years following the development of CADET BRAF, Breen focused on developing a strong proof of concept. Teaming up with the American Kennel Club, he recruited urine samples from hundreds of dogs to show that the approach could work with real patients.
His next step was commercialization. Breens startup, Sentinel Biomedical, was formed in 2015. Located right on NCStates campus, the company works to develop and scale diagnostic tests for the health care industry.
Since its formation, theyve developed another product called CADET BRAF-PLUS. The test is designed for dogs who dont have the BRAF mutation but do show clinical signs of TCC/UC. It can detect over two-thirds of bladder cancer cases not identified by CADET BRAF, increasing the overall detection sensitivity of the tests to over 95%.
Headquartered right on NCStates campus, Sentinel Biomedical seeks to improve diagnosis and treatment for dogs and their owners.
Find out more
Whats next for Sentinel Biomedical? It recently announced a joint venture with Antech Diagnostics, part of MARS. Together theyve formed Antech Molecular Innovations, also based on NCStates Centennial Campus, and work to broaden access to CADET BRAF and CADET BRAF-PLUS.
With the distribution channels of one of the worlds largest animal health providers, we are providing veterinarians with easy access to the tests we develop and enhancing our ability to become a global leader in innovation for veterinary molecular diagnostics, says Breen. And because our work is translational, we also have greater potential to translate our findings to humans.
This will bring the innovations developed at NCState to a whole new level.
Today, the National Cancer Institute spends $6 billion on cancer research annually, and its estimated that less than 0.5% is directed toward veterinary oncology. But Breen sees his innovations and those of his colleagues across the nation as promising steps in the right direction.
Currently, hes involved in a clinical study in the College of Veterinary Medicine that will evaluate the timeline between when a BRAF mutation is detected in a dogs urine and when that dog begins to show clinical signs of TCC/UC. Breen hopes this knowledge will lead to earlier intervention, improved quality of life and increased survival rates.
This will bring the innovations developed at NCState to a whole new level.
Recent collaborations with colleagues at Duke Cancer Institute are also exploring the genetic and environmental factors shared between canine and human bladder cancers. A study proposed by this multidisciplinary team was awarded funding from the V Foundation for Cancer Research in 2019. Such comparative oncology studies, Breen says, have the potential to realize the true value that dogs can bring to our fight against cancer.
Through Antech Molecular Innovations, Sentinel Biomedical has begun pursuing more projects to provide rapid, accessible molecular diagnostics for a variety of cancers that impact our pets and ourselves.
For now, Breen is excited to see his work take on a wider reach. These cancer detection tests will help a new generation of canine companions and their human friends (maybe even kids who are experiencing what Breen did as a child). Whats more, the increased volumes of data theyll collect may unlock insights that lead to the development of new treatment opportunities for cancers in both species.
Although we may not be able to help all dogs with cancer today, we are driven to learn from their cancers to help the dogs of tomorrow, and the families who care for them, says Breen.
Link:
Sniffing Out Cancer in Canines And Humans, Too - NC State News
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A Rare Genetic Disorder Turned These Siblings’ Blood ‘Milky’ White – Livescience.com
Posted: at 12:02 pm
A rare genetic disorder caused three siblings' blood to flood with fat and turn "milky" white, according to a new report of the unusual case.
The three siblings consisted of one set of fraternal twins (a daughter and son) and an older son, all born to a first-cousin couple in a Pennsylvania Dutch family. In their teens and early 20s, all three siblings experienced mysterious symptoms, including bouts of abdominal pain. They had all been diagnosed with hypertriglyceridemia, a fairly common disorder that causes fatty molecules called triglycerides to build up in the blood.
Now in their 50s, the siblings recently underwent genetic testing and learned that they have a condition that's much more rare, affecting only 1 in every million people, according to the case report, published today (Nov. 18) in the journal Annals of Internal Medicine.
Those with the ultrarare disorder, known as familial chylomicronemia syndrome (FCS), may accumulate more than 1,000 milligrams of triglycerides per deciliter (mg/dL) of blood. For comparison, normal blood levels of the fat should fall below 150 mg/dL, and 500 mg/dL would be considered "very high" in a healthy person, according to the National Institutes of Health.
Indeed, in people with FCS, blood fat levels are so high that the normally crimson fluid turns the color of milk. (FCS is not the only condition that can cause milk-colored blood; the symptom may also appear in people with severe hypertriglyceridemia.)
Related: The Color of Blood: Here Are Nature's Reddest Reds (Photos)
The three siblings had long struggled to keep their triglyceride levels under control and suffered frequent inflammation of the pancreas, also known as pancreatitis a serious condition that can cause abdominal pain, fever and vomiting. At the hospital, the male twin's triglyceride levels reached as high as 5,000 mg/dL, while the other brother's levels peaked at around 6,000 mg/dL. The female twin's triglyceride levels soared highest of all, reaching 7,200 mg/dL at maximum.
The siblings hoped their doctors could help subdue those aggressive symptoms.
To confirm the sibling's rare diagnosis, the doctors looked to their patients' genes. Triglycerides typically build up in the blood due to multiple malfunctioning genes and other related health conditions, such as diabetes or high-blood pressure, according to the Journal of the American Board of Family Medicine. But when doctors probed the siblings' genetic code, the researchers spotted only one mutated gene that was key for breaking down triglycerides in the body.
In healthy people, the gene contains instructions to build a protein called lipoprotein lipase (LPL), which typically coats the blood vessels that run through muscles and fatty tissues in the body, according to the Genetics Home Reference. LPL breaks down fats carried in the blood; without an adequate supply, the siblings' blood plasma ran thick with excess triglycerides.
Related: How to Speak Genetics: A Glossary
Each sibling carried two copies of the mutated LPL gene, meaning both their parents passed down the mutated genetic code to the children, the case report noted. What's more, the particular genetic mutation in the siblings had never been seen before, the authors said. The doctors placed the siblings on a fat-restricted diet, which successfully stabilized their triglyceride levels and quelled their bouts of pancreatitis. Sometimes, when triglyceride levels spike, doctors must manually replace the fat-filled blood of their patients with healthy blood from donors, Live Science previously reported. Thankfully, the siblings' condition could be curtained with diet alone.
Originally published on Live Science.
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A Rare Genetic Disorder Turned These Siblings' Blood 'Milky' White - Livescience.com
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NASA’s Plan To Reduce Planetary Protection For Mars Risks Accidentally Extinguishing Second Genesis Of Life Before We Find It – Science 2.0
Posted: at 11:59 am
Right now all our missions to Mars are sterilized to protect it from any Earth life that could hitch a ride and confuse the searches. A report by the Planetary Protection Independent Review Board recommends that NASA treats most of Mars similarly to the Moon for planetary protection. It comes with a cover letter from NASA recommending to their planetary protection officer that they implement the proposal. This would be fine if Mars was like the Moon. However, new discoveries show that Mars has liquid water there, in the form of brines, just a few centimeters below the surface. The measurements are indirect because we can't visit most of these locations yet and can't drill down even a few centimeters. There is now clear evidence of very cold brines even beneath the surface of the sand dunes that Curiosity drives over.
Their suggestion is to reclassify large parts of Mars as Category II (current classification for the Moon), meaning that there are no niches where terrestrial microorganisms could proliferate, or a very low likelihood of transfer to such places.
where there is only a remote chance that contamination carried by a spacecraft could jeopardize future exploration. In this case we define remote chance as the absence of niches (places where terrestrial microorganisms could proliferate) and/or a very low likelihood of transfer to those places.
COSPAR Workshop on Planetary Protection for Outer Planet Satellites and Small Solar System Bodies European Space Policy Institute (ESPI), 1517 April 2009
As far as I know mine is the only article to suggest that there may be very significant downsides to dropping planetary protection - most of what you see are articles praising NASA for moving with the times, and making things easier for commercial space and future planetary colonization.
(skip to What about the forwards direction? )
Curiosity can't drill down to examine the brines it detected indirectly, and also is not equipped with any specific life detection instruments. It can detect some organics related to life, but only after heating them up in a small oven until they decompose, then it analyses the evolving gases. Those particular brines are probably too cold for Earth life, but biofilms could create microhabitats to make them more habitable and there are suggestions for several other microhabitats in the equatorial regions that may be more habitable than the Curiosity brines.
The Moon has nothing like that.
The new report has few cites, and its main cite for this proposal is a controversial 2014 report. While the 2014 report was in process of publication, NASA and ESA took steps to get it independently reviewed. This 2015 independent review said the maps from the 2014 report are most useful if they accompanied by cautionary remarks that they represent incomplete knowledge. This new report by the Planetary Protection Independent Review Board doesn't cite the 2015 review or mention these criticisms of the main cite they rely on.
Overlay in white text: : "2015 review says maps represent incomplete knowledge. Extraterrestrial microbes may be here in salty brines just below the surface. Introduced Earth microbes could extinguish second genesis on Mars". Map from the 2014 report. Text summarizes one of the main criticisms of this report in the 2015 review.
Its important to get this right as there is no way to do a do over. It would be so sad to get to Mars, find life there, and then realize it was just life we brought ourselves. For many, the search for other lifeforms in our solar system is one of the major motivating reasons to explore Mars and other parts of our solar system with a potential for life.
This would also impact on the science interests of other countries. That includes the future discoveries of ESA (Europe), ROSCOSMOS (Russia), JAXA (Japan), ISRO (India), CNSA (China) and any other nation with an interest in exploring Mars. It's far easier to detect martian life, and know that it is from Mars, if there is no introduced Earth life there.
What we find on Mars could be absolutely unique. We can't make even the simplest of living cells from non living chemicals. We can make, or modify DNA, and we can insert DNA into a cell and use it to modify how it functions. However this only works if we have a pre-existing cell to modify. We can't make a new living cell from scratch. We don't know the details of all the chemical and physical processes that make up the simplest living cell, but even if we did, we still can't make it. Any attempt to build even the simplest RNA world cell, even if we knew the exact position of every atom in it, would fail. As soon as we start to assemble the chemical constituents they would react together to make a chemical mush. Our attempts to assemble early life in the laboratory (e.g. in the Szostack lab) are based on trying to accelerate chemical evolution, not assembling it from scratch. As Cairns-Smith put it in his "Seven Clues to the Origin of Life" (which approaches the problem of the origin of life like a detective puzzle modeled after Sherlock Holmes novels):
"Subsystems are highly INTERLOCKED within the universal system. For example, proteins are needed to make catalysts, yet catalysts are needed to make proteins. Nucleic acids are needed to make proteins, yet proteins are needed to make nucleic acids. Proteins and lipids are needed to make membranes, yet membranes are needed to provide protection for all the chemical processes going on in a cell. It goes on and on. The manufacturing procedures for key small molecules are highly interdependent: again and again this has to be made before that can be made - but that had to be there already. The whole is presupposed by all the parts. The interlocking is tight and critical. At the centre everything depends on everything"
(page 39 of Seven Clues to the Origin of Life)
If native martian life is especially vulnerable, for instance some form of early life, pre-DNA, we might make it extinct. There would then be no way to reconstruct it, even if we later found clues to how it worked before we made it extinct. This could also impact on the future commercial potential for Mars. Enzymes derived from extremophiles are already the basis for a billion dollar global industry. If we can find life based on a different biochemistry, this has a vast commercial potential. For details see Billions of dollars commercial potential of extraterrestrial biology (below).
Microhabitats for life and shallow subsurface habitats on Mars are likely to be undetectable from orbit. The harsh ultraviolet light would cause even surface lichens to huddle into partial shade in cracks and crevices. as they do in the high Antarctic mountains. Similarly it would be impossible to see life hidden beneath the surface of rocks, or beneath a mm or so of dust or deeper down in the top few centimeters of the Martian surface where, as we'll see, there are possibilities that conditions may be habitable for native as well as introduced Earth life.
The 2015 review found that maps of surface features" can only represent the current (and incomplete) state of knowledge for a specific time".
Text on image: Lichens on Mars would huddle in partial shade protected from UV, like this lichen in high mountains in Antarctica. It could not be seen from orbit with 30 cm resolution.
Pleopsidium chlorophanum in Antarctica From DLR press release Surviving the conditions on Mars
Pleopsidium chlorophanum on granite, collected at an altitude of 1492 m above sea level at "Black Ridge" in North Victoria Land, Antarctica. This photograph shows its semi-endolithic growth in Antarctic conditions. You can see that it has fragmented the granite, and that pieces of the granite are partly covering it, possibly helping to protect from UV light. Photograph credit DLR
See Lichens, cyanobacteria and molds growing in humidity of simulated Martian atmosphere
There are some dark hillside streaks near to the Curiosity landing site that grew and shifted in ways that suggested the presence of flowing water below the surface. Because of the possibility that these streaks could be habitable, Curiosity has to avoid them, because it is not sterilized sufficiently to go up to them to examine them. Importantly, these streaks were not discovered until after Curiosity landed on Mars. Also they are not proven to be dust cascades, as some say. It's one hypothesis that may have some truth to it, but there are many issues with it, such as the seasonality correlated with warmth and not correlated with winds, that the streaks fade too quickly over weeks rather than decades, and are too narrow for dust, and the problem of resupply from the top every year. Though the stopping angle matches the motion of cohesionless dust, there is likely to be liquid brines involved as well. See Dust cascades explanation,
If there is life on Mars, it's likely to be sparse and slow growing, like the life in our coldest driest deserts. Depending how much life is there, it may have almost no effect on the atmosphere, but it might have some effects we can notice. Curiosity has recently discovered variations in oxygen. Some process on Mars is creating more oxygen than expected in spring to summer, and less in mid winter, and the only correleation they have found is that less oxygen is produced when there is more dust in the atmosphere. They didn't find a correlation with seasonal and interannual pressure vartiation, or temperature variation. Could it be photosynthetic life? We also have the intriguing methane plumes also confirmed by ESA's trace gas orbiter.
Cassie Conley who used to be planetary protection officer for NASA puts it like this, as reported by Scientific American
Weve got engineers who are convinced that they know everything and biologists who still acknowledge that we still dont know very much. Fundamentally, that is the dispute.
Here is a video I made for this article (while working on the draft)
(click to watch on Youtube)
This article will focus on the forwards direction, the risk of sending Earth microbes to Mars because the legal protection in that direction is very weak.
In the backwards direction the legal protection is very strong indeed, far more than it was at the time of Apollo. Margaret Race of the SETI institute mapped out the laws that NASA would have to navigate to return a sample to Earth. I figure out, based on her list, that they should have started work on the legal process in 2010 or earlier to return a sample by 2032 as they plan. So, I don't think they are going to return it to Earth unsterilized myself. Most likely sterilize it, or return it to somewhere not in contact with Earth such as telerobotic study above GEO.
At any rate there is no risk of harm to Earth's biosphere. It would be looked at in great detail over a period of years and expert astrobiologists would be called as witnesses to testify and help keep Earth safe. For details about that, skip to Earth has strong legal protection/
Skip to: 2015 review and problems with maps
Since Earth is well protected in the backwards direction, for a sample returned from Mars, the main concern is for the forwards direction. Unlike the backwards case, there isnt any other legislation here to protect Martian life apart from the weak Outer Space Treaty. All the rules for planetary protection are based on a few phrases about harmful contamination. They have been interpreted as including "harmful to the scientific experiments of other parties to the treaty".
I think the way ahead here is to make sure everyone is on board and understands the importance of planetary protection - for scientists - and for colonization enthusiasts too. It's important for all of us to know what is there, and if there is life there that could harm humans or Earth's biosphere, or whether astronauts could impact adversely on martian life.
If these proposals were adopted in the forwards direction, you could send what you like to these regions of Mars, tardigrades, and extremophile blue green algae that have already been tested in Mars simulation chambers. The only requirement would be to document what you do. Eventually you could send humans too, with this category II classification, though returning them would be another matter if they had made contact with extraterrestrial microbes on Mars.
The report is here together with a cover letter from NASA recommending to their planetary protection officer that they implement the proposal:
One of their main cites is a report from 2014 by Rummel et al which proposed the use of maps to divide Mars into special regions which need especially careful planetary protection measures such as was used for the Voyager landers in the 1970s, and others that have less stringent requirements such as is used for Curiosity:
This is the basis for their proposal that Mars could be subdivided into regions some reclassified as category II. Although they dont go into detail, presumably they would use a map like the one in the 2014 review, and classify all except the uncertain regions as category II:
Map from the 2014 report. Purple is low in elevation, and grey is higher elevation. Red and blue lines delineating regions are approximately 50 km in width
In the text overlay I summarize the objection to this map in the 2015 review "2014 map of uncertain regions of habitability. 2015 review says maps can only represent incomplete knowledge."
Skip to: Vigorous debate in Nature and Astrobiology journal
Even before Rummel et als report was published, both NASA and ESA took steps to have it reviewed independently.
This 2015 review overturned several of the findings of the 2014 report, and in particular, it recommended against the use of maps [49] saying:
In general, the review committee contends that the use of maps to delineate regions with a lower or higher probability to host Special Regions is most useful if the maps are accompanied by cautionary remarks on their limitations. Maps [of] surface features can only represent the current (and incomplete) state of knowledge for a specific timeknowledge that will certainly be subject to change or be updated as new information is obtained.
5 Generalization of Special Regions and the Utility of Maps
This new NASA report doesnt mention the 2015 review. Its an extraordinary omission from a report that is recommending the use of maps for category II.
I dont know the reason for this omission. They certainly should have looked at this 2015 review, and not just at the original 2014 report, before making this recommendation to NASA to map out large parts of Mars as category II like the Moon.
The 2015 report used the example of Recurring Slope Lineae (RSLs) to explain why maps are not enough by themselves. These are seasonal streaks that form on sun facing Martian slopes. They appear in the Martian spring, grow and broaden through the summer and fade away in autumn.
These dark features are not themselves damp and may be dust flows. However, they are associated with hydrated salts and they may also be linked with salty water (brines) in some form. Sadly the HiRISE instrument can only observe them in the early afternoon locally, the driest time for the Martian surface, because of its high inclination sun synchronous orbit. This makes it especially hard to know if there are any brines moving down these slopes.
Warm Season Flows on Slope in Newton Crater (animated)
The first ones were found in higher latitudes, but many of these have now been found in the Martian tropics, especially on the slopes of the Valles Marineres. Their status is unknown, whether they could have habitats for Earth life or not. At present they are classified as
As such they meet the criteria for Uncertain Regions, to be treated as Special Regions. [a Special region is one that Earth microbes could potentially inhabit]
The 2015 review gives the example of the ExoMars Schiaparelli lander. All HiRISE images of the landing site were inspected for the possible presence of RSL's. [50]
As another example of this, 58 RSLs were found on Mount Sharp close to the Curiosity landing site.
Here are some of them:
Possible RSLs on mount Sharp not far from the Curiosity rover. These photos are taken at a similar time in the Martian year, they are less prominent in the earlier one in 09 March 2010 and more prominent with some new ones in the later image August 6 2012. Photo from supplementary information for Transient liquid water and water activity at Gale crater on Mars
Importantly, these were not discovered until after the Curiosity landing in 2012. See Slope activity in Gale crater, Mars (2015) and Nature article: Mars contamination fear could divert Curiosity rover
This shows that we mightnt always be able to rule out potential uncertain regions that could be habitats at a landing site. They may be discovered later, after the landing itself.
More RSLs have been found in the Mawrth Vallis region, one of the two final candidates for ExoMars landing site
These results denote the plausible presence of transient liquid brines close to the previously proposed landing ellipse of the ExoMars rover, rendering this site particularly relevant to the search of life. Further investigations of Mawrth Vallis carried out at higher spatial and temporal resolutions are needed to , to prevent probable biological contamination during rover operations,
Discovery of recurring slope lineae candidates in Mawrth Vallis, Mars
ExoMars isnt going to Mawrth Vallis, because they chose the other candidate Oxia Planum. I cant find anything about RSLs in Oxia Planum, but how confident can we be that this doesnt have RSLs or other potential habitats? Does non detection so far mean they arent there?
Skip to: Important habitats not covered by 2014 report
This new report also doesnt mention the long running and vigorous debate on the topic of whether we should relax sterilization requirements for spacecraft sent to Mars.
This debate started in two Nature articles in 2013 and has continued in Astrobiology journal through to 2019.
Both sides in this debate were in agreement that there is a significant possibility that Earth microbes can contaminate Mars.
Surely neither side in this debate would support classifying most of Mars as category II like the Moon.
Rather, the argument in Nature and Astrobiology journal is about whether we should reduce sterilization requirements for Mars in order to study these potential habitats quickly before human missions get there and make it impossible to study them in their pristine condition without Earth life.
The other side in this debate argue that we have a fair bit of time before humans get there, and that if we relax planetary protection we risk finding Earth microbes we brought there ourselves.
Those arguing for relaxing planetary protection are:
Against
This debate is not mentioned in this report.
Nor does it mention the many new potential surface or near surface habitats that have been proposed / indirectly detected / theorized since 2008. We have had more of these than there have been years since 2008.
Skip to: Nilton Renno's droplets
The 2014 report briefly considers these. The 2015 review expands on this topic, and says that to identify such potential habitats requires a better understanding of the temperature and water activity of potential microenvironments on Mars, for instance in the interior of craters, or microenvironments underneath rocks. These may provide favourable conditions for establishing life on Mars even when the landscape-scale temperature and humidity conditions would not permit it. [46]
The 2014 report looked at distributions of ice and concluded that ice in the tropics is buried too deep to be a consideration[47]
However the 2014/5 review corrected this due to evidence of ice present at depths of less than one meter in pole-facing slopes[48]
Research since then still hasnt resolved these issues.
Even the 2014 report acknowledged limitations:
"Claims that reducing planetary protection requirements wouldn't be harmful, because Earth life can't grow on Mars, may be reassuring as opinion, but the facts are that we keep dis4g life growing in extreme conditions on Earth that resemble conditions on Mars. We also keep discovering conditions on Mars that are more similarthough perhaps only at microbial scalesto inhabited environments on Earth, which is where the concept of Special Regions initially came from."
"A New Analysis of Mars "Special Regions": Findings of the Second MEPAG Special Regions Science Analysis Group (SR-SAG2)" (PDF).
Skip to: Does this matter:
Id like to cover a couple of these potential habitats to motivate this, then Ill look at why it is so important to protect Mars from Earth life - is it really so important to make sure we dont mix Earth life with Mars life before we canstudy it?
Skip to: Curiosity brines
Nilton Renno's droplets that form where salt touches ice - why did he call a droplet of salty water on Mars "a swimming pool for a bacteria"?
This is perhaps one of the most striking discoveries in recent years because of its implications for habitability of Mars. Nilton Renno found that liquid water can form very quickly on salt / ice interfaces. Within a few tens of minutes in Mars simulation
experiments.
Erik Fischer, doctoral student at University of Michigan, sets up a Mars Atmospheric Chamber on June 18, 2014. These experiments showed that tiny "swimming pools for bacteria" can form readily on Mars wherever there is ice and salt in contact.
This is striking as it could open large areas of Mars up as potential sites for microhabitats that life could exploit. The professor says
"If we have ice, and then the salt on top of the ice, in a few tens of minutes liquid water forms. Our measurements clearly indicate that. And it's really a proof that liquid water forms at the conditions of the Phoenix landing site when this salt is in contact with the ice.
"Based on the results of our experiment, we expect this soft ice that can liquefy perhaps a few days per year, perhaps a few hours a day, almost anywhere on Mars. So going from mid latitudes all the way to the polar regions.
" This is a small amount of liquid water. But for a bacteria, that would be a huge swimming pool - a little droplet of water is a huge amount of water for a bacteria. So, a small amount of water is enough for you to be able to create conditions for Mars to be habitable today'. And we believe this is possible in the shallow subsurface, and even the surface of the Mars polar region for a few hours per day during the spring."
(transcript from 1:48 onwards)
(click to watch on Youtube)
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Meet the robotic pioneers that will help humanity colonize Mars – Digital Trends
Posted: at 11:59 am
From NASAs upcoming Moon to Mars mission to Elon Musks ambitious plans touse a SpaceX Starship to eventually colonize Mars, the race to populate the Red Planet is already on. But before humans can visit Mars and set up any kind of long-term base there, we need to send out scouts to see the lay of the land and prepare it for manned missions.
The mechanical pioneers well be sending to Mars in the coming years will follow in the tire tracks of explorers like the Curiosity rover and the Insight lander, but the next generation of Martian robotics will use sophisticated AI, novel propulsion methods, and flexible smallsats to meet the challenges of colonizing a new world.
There are distinct difficulties in building machines which can withstand the Martian environment. First, theres the cold, with temperatures averaging around minus 80 degrees Fahrenheit and going down to minus 190 degrees Fahrenheit at the poles. Then theres the thin atmosphere, which is just one percent the density of Earths atmosphere. And then theres the troublesome dust that gets kicked up in any operations on the planets surface, not to mention the intense radiation from the Suns rays.
These environmental conditions create problems for robotics, from temperature variations which cause mechanisms to expand and contract and so wear over time, to dust getting into gears which prevents the use of exposed lubrication.
Its a very unique and extreme environment, even for space robotics, said Al Tadros, VP of Space Infrastructure and Civil Space at Maxar Technologies, which is the company that builds the robotic arms for NASAs Mars rovers. Maxars robotic arms must be able not only to survive this harsh environment, but also perform the tasks like digging and drilling which enable scientific investigations.
Another consideration is weight limitations. When a part has to be delivered to Mars via rocket, every single gram need to be considered and accounted for, and that requires carefully selecting materials. A lot of what we do uses different types of aluminum, Tadros explained. We also use titanium and in some cases we use carbon fiber, depending on the application. Other weight-saving tricks include hollowing out some sections that dont need to be so structurally strong, such as the length of a robotic arm which could be made from honeycomb matrix composite tubes.
When a rover has been delivered to the surface of Mars, it can start exploring. However, due to the distance from Earth, its not feasible for engineers to control rovers directly. Instead, the robots have a degree of autonomy in their explorations, with NASA exercising supervisory command.
They can tell the rover to go five meters in this direction, Tadros says as an example. If theres a problem executing that command, the rover will stop and wait for more instructions. Its rather rudimentary in that sense. But in the future, the desire is to have autonomy on board so the rover recognizes Oh, I was told to go five meters, but theres a boulder here. Ill go around in this direction because I know the terrain is open.
We need communication networks on Mars, both between two points on Mars and from Mars back to Earth.
With a map and local knowledge, rovers will be able to perform self-navigation. They will even eventually be able to perform science autonomously, so scientists would only need to specify a command like find this kind of rock and the rover could locate and analyze a sample. This kind of autonomy is already being planned as part of NASAs upcoming lunar mission with the VIPER rover, Tadros said. Its going to be doing rapid prospecting, looking at and characterizing the regolith and the rocks to look for ice and other materials.
With robotics like VIPER and theMarscopter launching as part of the Mars 2020 project, we can expect machines to scout and explore Mars, finding out about local resources and hazards which will help or impede the survival of humans on the planet.
Knowing where humans can safely land on Mars and where they can locate the resources they need is the first step towards colonization. But the real difference between a visit and a long-term stay on another planet is a matter of infrastructure. From water to communications to building habitats, well need to find a way to provide the basic necessities of life in a sustainable way.
One method for setting up early infrastructure is through the use of small satellites, or smallsats. If youre thinking of colonizing Mars, where the smallsats come in is setting up the infrastructure for the colony, said Brad King, CEO of Orbion, a company creating more efficient propulsion systems for smallsats. We need communication networks on Mars, both between two points on Mars and from Mars back to Earth. On Earth, weve solved many of these problems with orbiting satellites around our planet.
Smallsats could fulfill similar functions on Mars, by setting up a Martian equivalent to GPS we could call it the Mars Positioning System. They can also scout out the surface of the planet, preparing the area for the humans to come.
The issue is getting satellites from Earth to Mars in an affordable manner. Traditionally, craft have been moved through space via chemical propulsion that is, burning fuel to create thrust. This is a great way to create large amounts of thrust, such as the thrust required for a rocket to leave Earths atmosphere and make it into space. But it takes a massive amount of fuel, to such a degree that the biggest part of modern rockets is simply the fuel tank.
A cheaper alternative for moving through space is electric propulsion, which uses solar power to shoot an inert substance like xenon out of the back of the craft. This method is highly fuel-efficient, allowing the traveling of long distances with very little fuel. The downside is that this propulsion method is low thrust, so it takes longer to arrive at a destination. Sending a craft from Earth to Mars using electric propulsion might take a handful of years, compared to chemical propulsion with which the journey would take in the region of six to nine months.
We as humans cant hear something going wrong there, but when you translate that into data over time, AI can spot those subtle changes in deviation from the norm.
However, the principle doesnt only apply to small unmanned craft. A distinct advantage of electric propulsion is that it scales up very efficiently: Electric propulsion technology works better the bigger it gets, King said. In principle, theres nothing limiting the scaling up of electric propulsion to very large, crewed missions. You just start to run into economic hurdles because youre building Battlestar Galactica-sized craft to get there.
Electric propulsion has been used in projects like the Japanese Space Agencys Hayabusa craft, which recently visited the distant asteroid Ryugu. And there are more plans for electricity propelled craft in future projects, such as the power and propulsion element (PPE) module of NASAs Lunar Gateway station which use solar electric propulsion and will be three times more powerful than current capabilities.
Launching and landing on planets will still require chemical propulsion, but the journey in between could be made far more efficient. King suggests that a non-propulsive crew vehicle or cargo vehicle could be put into a cycling orbit that goes past Earth and Mars. Then you can essentially send things up and ride the bus to Mars, requiring no propulsion, he explained. A similar system has already been used for the Kepler Space Telescope, which used very little fuel after its launch into a Earth-trailing heliocentric orbit.
Of course, getting from Earth to Mars is only part of the journey. Once a craft arrives at Mars, it needs to slow down and enter orbit. To slow a craft, there are typically two methods: using reverse thrusters which require fuel, and aerobraking. The latter is where a craft dips into the outer atmosphere of Mars, using the aerodynamic drag to reduce the vehicles energy enough that when it comes out of the atmosphere, it can enter orbit.
The concept of electric propulsion has been somewhat fringe for the past several decades, but with these new projects its moved into the mainstream. Now its being applied on a large scale its like the transition of air travel from propeller driven aircraft to jet aircraft, King said.
So we can send robots to scout the surface and satellites to set up infrastructure. We could even move enormous constructions like habitats through space using minimal fuel through electric propulsion. But the challenges of Mars colonization dont only occur when humans are actually occupying an on-planet habitat. One major issue is how habitats and structures can be maintained for the long periods during which they will be unoccupied. Planned projects like NASAs Lunar Gateway station, for example, will likely only be occupied 20 to 30 percent of the time, and we can expect similar or even lower rates of occupancy for potential Mars habitats.
Off-planet habitats need to be able to monitor themselves and fix themselves, especially when the nearest human is millions of miles away. And for that, AI is required.
I believe that colonizing Mars is not a technological issue, its an economics issue.
A system recently launched to the International Space Station could provide the basis for AI habitat monitoring. BoschsSoundSee system consists of a payload containing 20 microphones, a camera, and an environmental sensor for recording temperature, humidity, and pressure. These sensors collect data about the environment, especially acoustic information, which can be used to flag up problems.
If you imagine there is a leak in the station, not only would there be ultrasonic tones, but also a pressure loss, Bosch research scientist Jonathan Macoskey explained. If we see both a pressure loss and an ultrasonic tone and other factors, thats a concrete way of identifying a problem.
Of course, a leak in the ISS would be loud, obvious, and dramatic. But many machine failures, especially in unmanned environments, are due to a gradual degradation over time. AI can be used to sense these things, SoundSee principal researcher Samarjit Das said, not by adding more or better sensors, but rather by using sensor data more efficiently to search for subtle patterns.
Machines dont just break down immediately from good to bad, Das said. There is gradual wearing down over time. Think of a system you might want to monitor in the ISS like a treadmill. The gears inside slowly degrade over time as its used. We as humans cant hear something going wrong there, but when you translate that into data over time, AI can spot those subtle changes in deviation from the norm.
Dont imagine future ships and habitats controlled entirely by AI though, or even worse a rouge AI like 2001s HAL. Sensors and AI wont replace humans entirely and automate everything, Das said. AI is a line of defense. Macoskey agreed: We see AI as a tool that enables new things in the same way that the microscope enabled humans to look at microscopic organisms.
With all these environment and logistical difficulties, it might seem as if sending humans to Mars at all is a long shot, let alone establishing any kind of permanent or semi-permanent base there. Although these are serious challenges, solutions do exist in the form of AI, robotics, and propulsion methods which are being tested now for use in future space projects.
I believe that colonizing Mars is not a technological issue, its an economics issue, King said. If we had the resources to spend, we know what needs to be built and we know how to build it. But the number of dollars or euros that it takes to do that is daunting.
With sufficient funding, we do have the knowledge to begin setting up communication systems, enabling transportation, and building habitats on Mars. King is confident that it could even happen within our lifetime: Given unlimited resources, we could set this infrastructure up in a decade.
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Space Cowboys, Chinas New Long March, Interplanetary Opportunities And Existential Risks Our New Age In Space – Forbes
Posted: at 11:59 am
In 1508, King Ferdinand II of Spain drafted his memoires. Youd guess the voyages he and Queen Isabella funded would have featured prominently in his personal puff-piece. Imagine bragging about your man Columbus discovering the New World as it was Eurocentrically termed. Oddly, Ferdinand didnt even mention the voyage in his first version.
Ferdinand II of Aragon, King of the Crown of Aragon (1452-1516) detail of wooden altar, Peruvian ... [+] folk art.
While a few monarchs were plotting routes to world domination, the preponderance of Europe paid little attention during those early years.
When forces begin to fundamentally challenge our worldview note the Earth-centric notion worldview only a few people truly pioneer.Most fail. A few make history. Thus we are poised for frontiers in space.
Space Cowboys and Cowgirls
I recently spoke for the New Worlds 2019 confab in Austin, Texas, an annual gathering of space enthusiasts. Hosted by Rick Tumlinson of the Space Fund and Earthlight Foundation, New Worlds focuses on space exploration and colonization. Tumlinson joined me for a trialogue at TWIN Global 2019 earlier this year (find our conversation here), then invited me to join the space race.
Comic book detail from the exhibit, Cowboys in Space and Fantastic Worlds, at the Bullock Texas ... [+] History Museum through December 1, 2019.
The venue for the event, the Bullock Texas State History Museum, hosts an intriguing exhibit Cowboys in Space, which explores the cultural synthesis of space and the American cowboy ethos. Surviving on any true frontier requires self-reliance, a conditions-relevant code of ethics and extraordinary courage the cowboy ideal.
As the exhibit and event explored, science fiction (cowboy or otherwise) generates visions for where we might go in the future.
Not Just For Billionaires And Comiconers
While the space community is still small, its passionate and making progress. Its not just for billionaires like Jeff Bezos and Elon Musk though their commitment is essentialand Comicon enthusiasts though New Worlds did include a fair dose of Comiconisity. Real businesses, from healthcare and resources to aerospace and defense, are actively investing in these early days.
Investors such as Dylan Taylor, Chairman and CEO of Voyager Space Holdings, see investable opportunities. We now have second and third generation entrepreneurs. The business cases are becoming more viable and industry expertise is becoming stronger. I expect this trend to accelerate.
While many presenters and companies impressed me, a group of young researchers and designers stood out. They were selected for their innovative, insightful work on challenges facing our future in space.
What struck me about their work was how relevant some of their insights are for us here on Earth. Out-of-this-world (literally) challenges catalyze ideas relevant for nearer-term terrestrial purposes.
Designing Our Futures In Space And On Earth
Many science fiction authors envision complicated physical environments in space, to help astronauts and travelers feel at home. University of Houston Space Architecture program student and MIT Media Lab visiting student Tamalee Basu is taking an alternative, low-cost holodeck-like approach. With few resources, she decided to try to create a light-weight immersive AstroPod within which an individual can experience any environment.
Some of Tamalee Basu's sketchs for her AstroPod concept, 2019
Basus building a cloth cocoon with 360-degree projection and interactive capabilities. One could envision running simulated environments or having near-real time conversations with colleagues or dinner with loved ones back on Earth.
While Basus idea arose from considering the challenges of spending years away from Earth, we wont need to wait for space to benefit from her idea. When AstroPod or some similar solution works, we could enjoy such devices on earth. Or anywhere. Low cost, fully 3D, 360-degree immersive virtual spaces.
Mockup of a real-time Space-to-Earth meal experience with two participants, via an AstroPod. ... [+] Tamalee Basu
Over the next decade, well transcend the notion of virtual reality goggles and create dedicated virtual spaces with a variety of form factors and use cases. Basus insights from considering potential needs in space could inform progress here at home.
Near-Space Opportunities
Even in space conventionally defined by the Krmn line, or 100 km above Earths sea levelinvestable opportunities already exist. Aquarian Devices endeavors to build communications networks orbiting Earth, and eventually to the realm between Earth, the Moon and Mars. CEO Kelly Larson explained, Were already signing MOUs with customers who already have needs for orbital-to-earth communications not well-satisfied by current solutions, or who see rapidly expanding requirements in the near future.
Whether building the definitive telecommunications network for near-space requires 3 years or 30, someone will win big. Many players will die painful deaths, but any business or government with reasons to engage should be paying attention. Inter-galactic prizesand investment black holes loom.
Chinas Centennial Vision
Whilst space race veterans like the United States, Europe, Japan and Russia continue apace, and new entrants like the UAE and India rise, the most compelling plans explored at New Worlds came from China. Namrata Goswami, a MINERVA grantee from the US Office of the Secretary of Defense, presented an overview of the Peoples Republics long-term vision and activities.
China endeavors to be the foremost nation in space by 2045ahead of their 2049 Centennial Celebrations. Initiatives include Lunar and asteroid mining by 2034 with a permanent presence by 2036 and industrial scale space-based solar power by 2050. Thus far, China has largely achieved announced timelines.
The Shenzhou X spacecraft carried by a Long March-2F carrier rocket installed at the launch pad in ... [+] Jiuquan, Northwest China's Gansu province the morning of June 3, 2013. China launched the Shenzhou X spacecraft to advance their manned space program. The spacecraft carried three astronauts to visit the Tiangong-1 space module, state media reported. CHINA OUT AFP PHOTO (Photo credit should read STR/AFP via Getty Images)
Meeting epochal objectives requires deep, motivating belief. Chinas leadership equates their space ambitions to a new Long March, referring to the multi-year retreat of the Chinese Communist forces in the 1930s that enabled them to overcome their Nationalist adversaries and eventually found the Peoples Republic of China.
Chinas long-term vision to conquer space deserves respect. The countrys activities also pose cooperative opportunities and competitive threats for the US, Europe, India and others.
Americas To Win Or Lose
In contrast to Chinas centrally controlled efforts, a few commentators at New Worlds espoused Americas decentralized, entrepreneurial ferment of thousands of organizations generating many paths to the future. The American Cowboy ideal.
But we must humbly recognize that China has also proven itself capable of impressive success at new ventures. Entrepreneurial advantages require entrepreneurial commitments.
Space is not Americas birthright, though neither is it anyone elses. America must take a leadership role with willing partners worldwide to ensure globaland interplanetary security and prosperity. This will require Herculean efforts over decades, though failure could be existential.
America must up its game. Provide more public funds for space-related research, technology and infrastructure at a scale necessary to de-risk opportunities for investors. Encourage initiatives like Tumlinsons efforts to expand public and private sector engagement and build the community dedicated to space.
Expect many hype cycles and crashes (financial and physical) before space becomes a normal course of business. Nonetheless, be assured the heavens will look very different 30 years from now thus so will life on Earth.
Queen Isabella and King Ferdinand might not have recognized the magnitude of change they catalyzed, but others did. Some attained fame and fortune, while many others died on the high seas. They collectively transformed the world. Yet again, limitless frontiers await.
Tomb of King Ferdinand II of Aragon and Queen Isabella of Castile, Spain, engraving by Lemaitre from ... [+] Espagne, by Joseph Lavallee and Adolphe Gueroult, L'Univers pittoresque, published by Firmin Didot Freres, Paris, 1844.
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U.S. judge awards $180 million to reporter held and tortured by Iran – Los Angeles Times
Posted: at 11:56 am
A U.S. judge has awarded a Washington Post journalist and his family nearly $180 million in their lawsuit against Iran over his 544 days in captivity and torture while being held on internationally criticized espionage charges.
The order in the case filed by Jason Rezaian comes nearly a week after Iranian officials shut down its internet and launched a security crackdown on protesters angered by a sharp rise in government-set gasoline prices. As internet access has slowly trickled back on, the U.S. government sanctioned Irans telecommunications minister in response to the internet shutdown.
U.S. District Judge Richard J. Leon in Washington entered the judgment late Friday in Rezaians case, describing how authorities in Iran denied the journalist sleep and medical care and abused him during his imprisonment.
Iran seized Jason, threatened to kill Jason, and did so with the goal of compelling the United States to free Iranian prisoners as a condition of Jasons release, Leon said in his ruling. Holding a man hostage and torturing him to gain leverage in negotiations with the United States is outrageous, deserving of punishment and surely in need of deterrence.
Iran never responded to the lawsuit despite its being handed over to the government by the Swiss Embassy in Tehran, which oversees U.S. interests in the country. Irans mission to the United Nations did not immediately respond to a request for comment Saturday.
Rezaian and his lawyers did not respond to a request for comment. Martin Baron, executive editor of the Post, said in a statement that Rezaians treatment by Iran was horrifying.
Weve seen our role as helping the Rezaians through their recovery, Baron said. Our satisfaction comes from seeing them enjoy their freedom and a peaceful life.
Rezaians case, which began with his 2014 gunpoint arrest alongside his wife, Yeganeh Salehi, showed how the Islamic Republic can grab those with Western ties to use in negotiations. Its a practice recounted by human rights groups, U.N. investigators and the families of those detained.
Despite being an accredited journalist for the Post with permission to live and work in Iran, Rezaian was taken to Tehrans Evin prison and later convicted in a closed trial before a Revolutionary Court on still-unexplained espionage charges.
Iran still focuses on the case even today, as a recent television series sought to glorify the hard-liners behind the arrest.
It remains unclear how and if the money will be paid. It could come from the United States Victims of State Sponsored Terrorism Fund, which has distributed funds to those held and affected by Irans 1979 student takeover of the U.S. Embassy in Tehran and subsequent hostage crisis. Rezaian named Irans paramilitary Revolutionary Guard, this year designated as a terrorist organization by the Trump administration, as a defendant in the case.
The order comes a week after the Nov. 15 gasoline price increase, which sparked demonstrations that rapidly turned violent, seeing gas stations, banks and stores burned to the ground.
Amnesty International said it believes at least 106 people died in the unrest and the crackdown. Iran disputes that figure without offering its own. A U.N. office earlier said it feared the unrest may have killed a significant number of people.
Starting Nov. 16, Iran shut down the internet across the country, limiting communications with the outside world. That made determining the scale and longevity of the protests difficult.
Since Thursday, that outage has begun to slightly lift. By Saturday morning, internet connectivity stood below 20% of normal levels, according to the monitoring group NetBlocks.
The U.S. Treasury on Friday sanctioned Iranian information and communications technology minister Mohammad Javad Azari Jahromi over the internet shutdown.
Jahromi, the first government minister to be born after Irans 1979 Islamic Revolution, is widely believed to be considering a presidential run in 2021. In sanctioning him, the U.S. Treasury noted he once worked for the countrys intelligence ministry and has advanced the Iranian regimes policy of repressive internet censorship.
Jahromi, known for his social media persona, has increasingly criticized President Trump on Twitter, a service long blocked in Iran. Being sanctioned may raise his profile among hard-liners.
He dismissed the sanctions on Twitter as Trumps fairytales.
Ill continue advocating access to Internet & I wont let US to prohibit Iran development, he wrote.
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Meet the Microchipped Transhumanist Cyborg Whos Running Against Trump in the 2020 GOP Primary – Mediaite
Posted: at 11:56 am
Zoltan Istvan, a transhumanist journalist, is running for the U.S. presidency as a Republican in 2020, challenging President Donald Trump in the primary.
Istvan, who also ran for president in 2016 on a lesser scale, has written for The New York Times, Vice, and National Geographic, and describes himself as the founder of the Transhumanist Party, the original author of the Transhumanist Bill of Rights, and a frequently interviewed expert on AI, genetic editing, tech policy, and futurism.
His campaign policies for 2020 range from the relatively normal to the quite absurd, from ending the drug war, beating China in the artificial intelligence race, restoring the environment, and providing universal basic income for all, to the development of artificial wombs, nearly open borders, stopping mass shootings and terrorism with drones, robots, AI scanners, and other technology, and licensing parents, or as Istvan explained, requiring prospective parents to pass a series of basic tests, similar to a DMV driving test, to quality and get the green light to get pregnant and raise children.
As a passionate transhumanist (or, as philosopher Max More explains, someone who supports the evolution of intelligent life beyond its currently human form and human limitations by means of science and technology), reportedly with a microchip in his hand that allows him to open doors and use his phone, Istvan also wants the Republican Party to reclaim transhumanism from the far-left.
This week, Mediaite got the opportunity to talk with Istvan about his 2020 campaign and the policies within.
Your campaign policies are very interesting. Typical libertarian policies mixed with some quite out-there stuff like artificial wombs, nearly open borders, and stopping borders with drones. What was the inspiration behind such an odd variety of campaign focuses?
I was busted for dealing marijuana I guess maybe 26 years ago, where I was convicted of a felony conviction for distribution of narcotics, which also made me highly libertarian kind of from the start of my adult years. And then as I went through the National Geographic days I began to try to think about what would be better policy so we didnt get in these wars all the time and the government sort of left us alone. But at the same time, its not that I want to be left alone entirely. I think there should be some safety nets.
If you look through some of my 2020 plans youll see theres a lot of liberalism built into it, so it kind of tries to take the very best parts from all the different ideologies that are out there and put it in one. To be honest, I just dont understand why there cant be conservative people like myself who are totally socially liberal, and while thats classic libertarianism, the reality is that the Libertarian Party just doesnt have enough connections, money, and all these other things to run campaigns that can actually win office, which is ultimately why Im now with the Republicans trying to make a difference, trying to get people that might be fiscally conservative to have some sensibility when it comes to being more open-minded.
You say on your campaign website that youre trying to reclaim transhumanism from the far-left. What do you mean by that?
Thats probably my number one policy goal right now, and its because whats happened recently, at least in the last four or five years, is it seems like transhumanism has been growing dramatically. Im excited about that, but its also growing dramatically to the left, and if it continues to grow and grow in that direction it means that it will be almost this socialist dystopia, in my opinion, where everyone thinks they own everything and they can just do what they want.
Innovation, capitalism and Im saying this from an entrepreneur of twenty years it requires free markets in many ways to come up with these creative ideas in the first place. We all love going to Europe. We all love the quasi-socialism that they have there when were there. But Europe hasnt really created anything innovative in fifty years. I mean not much when you compare to, lets say, America. We want to be careful that in order for transhumanism to survive, it doesnt fall into the hands of the new breed of socialists that America is contending with. Silicon Valley is going that direction, Ive been watching that happen over the last ten years, and so I thought it was finally time somebody stood up and said, Wait a second, we need a better balance here. We need a balance of people who are willing to innovate in libertarian-minded economical ideals without bowing down to the far left.
So do you think transhumanism would die out if we did end up with a socialist society?
No. I dont think it would die out. I just think so you gotta understand the number one goal of transhumanism is really to try to overcome biological death by finding technology. And really, what happens when you put socialism into medicine and some of these other things, innovation dramatically stops. So somebody like myself whos 46-years-old, and of course all the other older people that have been involved in the movement forever, if innovation and science and all that other stuff stopped just even for ten or fifteen years, or doesnt go as fast as it is, a huge amount of extra people wont make it to this new generation where well have all these different techniques to keep people alive.
So theres actually a race going on. A race to keep transhumanism in kind of this capitalistic, libertarian somewhat framework so that innovation continues to move forward and that people like myself will have a chance in thirty years to actually benefit from these life extension medications and innovations that come out.
If we are able to overcome death with science by 2030 versus the year 2050, over one billion lives will be saved. So the meaning here is incredibly important, which is why Im very cautious about socialists being in charge.
Are you not worried that we could end up with a Fallout: New Vegas Mr. House situation, where you have a really really rich guy, or a bunch of rich people who are practically living forever, while no one else can get access to this technology?
That is one of my number one fears.
First of all, from a transhumanist perspective, if everyone lives forever, were going to have overpopulation problems, and I already believe we have overpopulation problems. You can see the climate changing and things like that.
But I think the other one is, whats to keep the Mark Zuckerbergs and the other people of the world from taking this radical technology, using it on themselves, and leaving the rest of us behind? This is where I lose a little bit of my libertarianism, and all the libertarians get mad at me. I actually think under these circumstances there should be some government mandate when it comes to healthcare, when it comes to different types of rights to life extension. That we should all have some type of a universal right to life extension and some of these medicines, even it requires government grants and things like that, because the very last thing that I want to do is create a world where only the one percent has access to these technologies, or even beyond the one percent, and the rest of the people get left behind in some kind of dystopia.
So, this is where I kind of break down and say a little bit of big government is fine, especially if its going to protect and make sure everyone has benefits to this new future that were talking about: the Transhumanist Age.
Do you think there are already some minor life extension schemes going on in the one percent?
I dont believe that theres a conspiracy going on with the one percent, because if it is, I havent heard about it. There are companies like Human Longevity. They cater only to the very wealthy But its not that they dont cater to the super poor, its just that their prices are expensive and theyre not covered by insurance, so only the very wealthy use them.
I would be very surprised if even someone like Peter Thiel has a very strict regiment of kind of undercover, secretive longevity people. I think were all working on this together. We realize the humanitarian aspects of making us all live longer. The person who could come up with the magic pill, or 3D-printing organs, however were going to keep ourselves alive longer, I think not only is it the most important capitalistic thing someones going to become a trillionaire off these kinds of innovations but I also think theres a very deep humanitarian aspect to share with your family, your friends. So I dont think people are hording this technology. I just dont think weve come up with the right technologies yet.
But if you look at the statistics, five years ago this was maybe a one or two billion dollar industry when you talk about longevity, and Bank of America recently said its going to be a 600 billion industry by 2025. I mean it is skyrocketing in terms of venture capital and investment. A lot of money is coming into it, so I hope by now in the next two to five years youre going to have a lot more innovation and announcement.
It seems like youre putting up more of a fight this primary to beat President Trump. Last election you put up a fight, but you werent listed on the ballots, whereas this time youre going to be listed on some the ballots, right?
Yeah, were going to be on basically all the ballots we can be until Super Tuesday, and were going to see how we do. Were spending a lot of our funding for ballot access right now, but thats okay. What happened is the first time around, I had some unique ideas. Of course, I had been a writer for a lot of major media, and so people listened and they liked those ideas, but for the Transhumanist Party as an independent, you really cant make any ground unless you have ballot access.
Were hoping that if we do well in New Hampshire, and were hoping that if we do well in Iowa, maybe get a few delegates here, then we could all of a sudden take it to the next level and make a real push to try to compete against Trump.
Id be lying to you if I said, Look, I think were going to win this thing. Thats not really what were trying to do. What were trying to do is get the attention of the Republican Party and say, Isnt it time there could be a new way of looking at things? Does it always have to be fiscally conservative and also conservative moral values? Why doesnt the Republican Party open itself up to socially liberal values? They would make a lot more room for people like myself who fit right there in the middle. Who dont want to necessarily give up all their money to the government, but also want to say to people, Hey you can do exactly what you want to do with your body. This is something that I dont think the Republican Party has had yet from any kind of public figure or anyone whos run a real viable campaign.
If you could address Republican voters right now with a short statement, what would you say?
The premise here with Trump is that we were promised greatness, and that sounded kind of neat in the beginning, and I was excited not to have an attorney at the top of the chain of command in America, but it turns out that Trump didnt really deliver that.
All we have are these squabbles in America. It seems like peoples views are just attacking each other. I really think its time not only just for a professional to be in the White House, but for somebody with really brand new ideas. And I dont mean empty the swamp. I mean lets fly above the swamp. Why do we even need to be in the swamp anymore? This is the kind of thing Im trying to bring.
Photo courtesy of Zoltan Istvan.
This interview has been edited and condensed for content and clarity.
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