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Category Archives: Transhuman News
In the balance hangs our well-being – Stuff.co.nz
Posted: December 1, 2019 at 9:50 pm
OPINION: There's an old saying that paraphrases Lewis Carroll's Cheshire Cat: "If you don't know where you're going, any road will do".
Sir Peter Gluckman and Dr Mark Hanson include it intheir new book,Ingenious: The Unintended Consequences of Human Innovation, which charts the 150,000 years of biological and cultural evolution that has made us such incredible innovators.
Since stepping down as the Prime Minister's Chief Science Advisor last year, Gluckman has been asking the big existential questions Can we deal with climate change? Will artificial intelligence surpass us? Are superbugs going to wipe us out?
As he was advocating for evidence-based decision making and informed public debate, we saw the rise of anti-science, alternative facts andTrumpism. Our ability to find consensus on the important issues seems to be diminishing.
READ MORE:* Why NZ should rethink rules on genetic modification* Testing standards were a hot meth* The high public cost of muzzling scientists
As Hanson, aprofessor of cardiovascular science at the University of Southampton, and Gluckman point out, we have harnessed technology to develop and thrive while other species live much as they did 10,000 years ago.
Still, every innovation has unintended consequences. The coal powering our dark satanic mills of industry deposited the carbon in the atmosphere that is now dangerously warming the planet.
Processing and preserving food created the energy-dense diet that is fuelling the obesity epidemic.
Hygiene and antibioticssaved lives but the side effects have been antibiotic resistance and autoimmune diseases.
CHRISTEL YARDLEY/STUFF
Sir Peter Gluckman, pictured, and coauthor Mark Hanson want genuine, informed discussion on science-related issues.
We've effectively run a series of live experiments throughout history and got away with it.
The authors of Ingenious worry that now we face "runaway cultural evolution". The pace of change is so great, the problems so wicked, we risk blundering down a dead-end.
What's the answer? GluckmanandHansonwant a better way of making trans-national decisions on whether new innovations such as genetic modification and climate geo-engineering should be used.
They want genuine, informed discussion on science-related issues, more respect for science, an education system that produces critical thinkers.
This will take time we may not have.
History tells us that we will again needtechnology to solve the problems past technologies have created.
As the authors soberly put it:"In the balance hang our well-being, our social relationships, our health, our environment, our economies, our governments, and our planet."
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Proof-of-Concept Study of CAR-NK Cell Therapy with Engineered Persistence Shows Potential – Cancer Network
Posted: at 9:50 pm
A first-of-kind multi-antigen targeted off-the-shelf chimeric antigen receptor (CAR)-natural killer (NK) cell with engineered persistence has the potential to be a readily available treatment option for patients, Robert A. Brodsky, MD, said in a preview of the 61st American Society of Hematology (ASH) Annual Meeting & Exposition.
As most of you are well aware, CAR T-cell (therapy has) captured the imagination of physician scientists and patients alike, mainly for their incredible efficacy in treating B-cell malignancies like acute lymphocytic leukemia and non-Hodgkin lymphomas, said Brodsky, who serves as secretary of ASH and is also the director of the division of hematology at Johns Hopkins Medicine.
However, he added, this treatment option does not come without its drawbacks: namely, time, expenses, toxicity.
Only about two-thirds of patients enrolled in CAR T-cell trials will actually see infusion because often the disease will progress during the time it takes to make a successful product, Brodsky said.
Therefore, there is a need to develop a more timely infusion that can be associated with lower costs, and hopefully, less toxicity.
At the upcoming ASH Annual Meeting & Exposition, being held from December 7-10 in Orlando, Florida, Jode P. Goodridge, PhD, will present on his teams proof-of-concept study of induced pluripotent stem cell (iPSC)-derived effector cells.
iPSC-derived effector cells offer distinct advantages for immune therapy over existing patient- or donor- derived platforms, both in terms of scalable manufacturing from a renewable starting cellular material and precision genetic engineering that is performed at the single-cell level, the researchers wrote in their abstract. iPSC derived natural killer (iNK) cells offer the further advantage of innate reactivity to stress ligands and MHC downregulation and the potential to recruit downstream adaptive responses.
The candidate, called FT596, is consistently manufactured from a master iPSC line engineered to uniformly express an NK cell-calibrated CD19-targeting CAR, an enhanced functioning high-affinity, non-cleavable CD16, and a recombinant fusion of IL-15 and IL-15 receptor alpha for cytokine-autonomous persistence, according to the abstract.
What the authors here did is take advantage of the use of induced pluripotent stem cells and differentiated them to natural killer cells. Natural killer cells are not T cells but they are another form of lymphocytes that can be very effective in killing cancer cells. What they did is they engineered these pluripotent stem cells to target B cells, and they are specifically targeting the CD19 antigen on B cells and showing that these are very effective in cell line models and animal models, explained Brodsky.
However, of note, this product has not been tested in humans yet.
The big advance here is that this offers the potential of having a readily available source of basically CAR-NK cells that wouldnt need time to grow them up before they would be infused, Brodsky concluded.
Goodridge JP, Mahmood S, Zhu H, et al. FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies. Presented at: 61st ASH Annual Meeting & Exposition Meeting preview; to be presented December 7, 2019; Orlando, Fla. Abstract 301.
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Proof-of-Concept Study of CAR-NK Cell Therapy with Engineered Persistence Shows Potential - Cancer Network
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Genetic Engineering Market Swot Analysis by Market Segments Applications and Types. (Thermo Fisher Scientific Inc., GenScript, Amgen Inc., Genentech…
Posted: at 9:50 pm
The market study report by reportsvale.com entitled Global Genetic Engineering Market Size, Status and Forecast 2019-2025 emphasizes on changing dynamics, growth-driving factors, restraints, and limitations. This allows understanding of the Global Seed Germination Trays market and benefits from any fruitful opportunities available in the report. It includes a detailed analysis of the Global Genetic Engineering in customer requirements, customer preferences, and the competitive landscape of the overall market. The study is divided into two segments i.e type and applications.
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Detailed Segmentation of the market:
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Based on regions, the market is expected to grow across various geographic regions, such as:-
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There are 13 chapters to present the Genetic Engineering Market.
Table of contents 1. Report Overview2. Global Growth Trends3. Market Share by Manufacturers4. Genetic Engineering Market Size by Type5. Genetic Engineering Market Size by Application6. Production by Regions7. Genetic Engineering Consumption by Regions8. Company Profiles9. Genetic Engineering Market Forecast10. Value Chain and Sales Channels Analysis11. Opportunities & Challenges, Threat and Affecting Factors12. Key Findings13. Appendix
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Future of India’s Agriculture Economy lies in Crop Diversification – Grainmart News
Posted: at 9:50 pm
The future of Indias agriculture economy lies in crop diversification. The continued practice of wheat and paddy crop production pattern since the Green revolution has adversely impacted the natural resources. Indian government needs to promote growing of less water consuming crops like oil seeds, cotton, pulses and maize. Growing of paddy led to depleting water table, soil fertility issues and stubble burning in the states of Haryana, Punjab and Uttar Pradesh.
Crop diversification refers to the growth of more variety of crops or changes in the existing pattern of crop production. The downgrading ecological situation, depleting groundwater levels and declining fertility of soil clear the need for crop diversification. This is aimed at increasing farmers income and decreasing negative impacts on the environment while also conserving the natural resources. Besides, it also helps to minimize price fluctuations and balance food demand.
Bringing diversity in crops results in strengthening ties between crop culture and livestock. It ensures the availability of rural employment around the year and future of Indias agriculture economy. It also results in crop intensification (increase yield per hectare) through the genetic engineering of plants. Crops grow in their required environmental conditions thus removing the barriers of lack of irrigation. On top of it, it brings back the soils nutrient profile and environmental sustainability.
Crop diversification is not only essential from the farmers perspective but also the trade balance perspective. Currently, India imports a huge quantity of edible oil from Indonesia and Malaysia. Increase in oil seeds farming in India may help curb the edible oil imports. Similarly, India imports an estimated two million tons of pulses on yearly basis. Government hiked MSP in pulses in order to promote cultivation of pulses in many states in India. This year India also imported huge quantities of b grade maize to meet demands of poultry feed farms. Maize can be a profitable crop for farmers to grow in 2020. Also, to maintain soil fertility, it is essential to grow crops like oil seeds, pulses, cotton and maize.
The incentives provided by the government do not yield the desired results. Government provides high MSP rates for paddy and wheat which leads to many farmers growing the same. The reason for lack of crop diversification in India is the financial overpower of the traditional crop over the new crop. Agricultural planning is necessary to control excessive farming of paddy and wheat and for future of Indias agriculture economy. Every year we find reports of stock of wheat and rice being rotten at warehouses of Food Corporation of India. Dead stock of wheat and rice keeps lying at FCI warehouses and we import high quantities of pulses and edible oil to meet the demand.
In conclusion, this loss making habit needs to change with better agricultural planning in India. The launch of schemes to save water and take up production of crops other than paddy in the north-western region of India has not yielded positive results. Government attention and farmers education are also essential for adopting sustainable farm practices.
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Future of India's Agriculture Economy lies in Crop Diversification - Grainmart News
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As Texas elections get tighter, more third-party candidates are making inroads – Houston Chronicle
Posted: November 30, 2019 at 10:27 am
Surrounded by fellow Libertarians during a 2018 election night watch party at a rented Airbnb in Fort Worth, Eric Espinoza, who was running for state Rep. Jonathan Sticklands seat, saw a Facebook message notification pop up on his phone.
Its people like you who are preventing other candidates from winning, he recalls the message saying, though he doesnt recall which candidate the sender supported.
I was like, Hey, guys, look I think I finally made an impact, Espinoza remembers saying, as he passed his phone around to others in the crowded living room.
That to me was like, OK, cool, I was able to affect something so much that somebody who knows nothing about me, and nothing about why I ran, blames me for somebody losing when its not the votes. Its not that I took votes from them; its that people didnt want to vote for that person, and they had a better option.
Republicans and Democrats alike will blame third-party candidates for siphoning votes from traditionally two-way races. Espinoza not only took votes that might have gone to Stickland, a Republican, but he had more votes than Sticklands margin of victory. Stickland beat his Democratic challenger by fewer than 1,500 votes, and Espinoza, in third place, had racked up more than 1,600.
Its still rare for third-party candidates to capture enough votes to potentially sway an outcome in the past three general elections, there have been just six such instances, according to a Hearst Newspapers analysis. But the number is growing, in a sign of tightening Texas elections.
Tight races getting tighter
As races in Texas become tighter, more third-party candidates are having an impact on elections. Over the past three general elections, there were six races in which a third-party candidate won more of the vote than the margin of victory.
Year
Race
Highest-Scoring Third-Party Candidate
Party
Third-Party Candidate's Percentage of the Vote
Margin of Victory
2014
U. S. Representative District 23 (Democrat Incumbent Democrat Pete P. Gallego and Republican Will Hurd)
Ruben Corvalan
Libertarian
2.54%
2.10%
2016
U. S. Representative District 23 (Republican Incumbent Will Hurd and Democrat Pete P. Gallego)
Ruben S. Corvalan
Libertarian
4.74%
1.33%
2016
Member, State Board of Education, District 5 (Republican Ken Mercer and
Democrat Rebecca Bell-Metereau)
Ricardo Perkins
Libertarian
4.72%
3.94%
2018
State Representative District 132 (Republican Mike Schofield and Democrat Gina Calanni)
Daniel Arevalo
Libertarian
1.66%
0.17%
2018
Member, State Board of Education, District 12 (Republican Pam Little and Democrat Suzanne Smith)
Rachel Wester
Libertarian
2.66%
1.52%
2018
State Representative District 92 (Republican Incumbent Jonathan Stickland and Democrat Steve Riddell)
Eric P. Espinoza
Libertarian
2.75%
2.39%
In 2014, one third-party candidate had the potential to affect a races outcome. In 2016, there were two such races. And in 2018, there were three. (None won an election.)
Two of the six races were Republican U.S. Rep. Will Hurds victories in Congressional District 23 in 2014 and 2016. Two were State Board of Education races.
Only one of those third-party efforts could be considered an outright spoil, when Libertarian Daniel Arevalo got 1,106 votes in a Texas House race in 2018 that saw Democrat Gina Calanni beat Republican incumbent Mike Schofield by just 113 votes.
In all six races, the margin of victory was low, most at about 2 percent or less, and the third-party candidates were Libertarian.
A year after some of the most competitive state-level races in decades, Texas Republicans moved to make it easier for third-party candidates to receive and maintain a spot on the ballot. In doing so, they returned ballot access to the Green Party after it lost it following the 2016 election.
Maybe Republicans are just kind of viewing this as, either you could call it an insurance policy or maybe its a way to subject the Democrats to things theyve been subjected to on the part of the Libertarians, said Phil Paolino, an associate professor of political science at the University of North Texas who has studied the effect of third parties on presidential races.
As elections get tighter, Paolino said, you might see a few more races where third-party candidates are able to cover the margins whether itll have the effect of altering the results is a big question.
During a more competitive election, with the stakes higher, some voters may be less likely to vote for third-party candidates and risk a major partys chances, Paolino said. In the six recent cases where third-party candidates drew more votes than the margin of victory, its impossible to know the outcome if they hadnt run whether their supporters would have voted for a Democrat, Republican or skipped going to the ballot box at all, he said.
For subscribers: Texas Green Party has qualified for 2020 ballot and welcomes Democrats climate change focus
If the Republicans behind the bill were hoping to hurt their Democratic competitors by allowing Green Party candidates, who typically pull votes from Democrats, onto the ballot, that appears unlikely from a historical standpoint, at least. Green Party candidates never came close to tipping a race when they were on the ballot in 2014 and 2016.
Whitney Bilyeu, a representative to the Libertarian National Committee for a five-state Southern region that includes Texas, said she thinks Republicans and Democrats in Texas are getting very afraid of us.
When we see things like this, which we expect them to continue to happen, it is a sign that people are finally figuring out, No. 1, they have other options, Bilyeu said. And No. 2, that third option, which is us, is the only one that actually gives them what they want and are about what they claim to be about.
Bilyeu said both major parties have reacted to Libertarian candidates success by trying to limit their access to the ballot.
The Texas Green Party did not respond to requests for comment.
Another voice that is pushing ideas
Republican Rep. Drew Springer, who sponsored the bill, said he hadnt studied third-party election results until a reporter presented him with an analysis. The North Texan has run unopposed since he was first elected in 2012.
Springers bill required that third-party candidates either pay a filing fee or submit a petition to run for election, just as major party candidates are already expected to do. Filing fees range from $300 for a State Board of Education seat to $3,125 for a U.S. House race.
Prior to Springers bill passing, Republican Rep. Mayes Middleton had tried to pass a bill, HB 4416, which would have doubled the threshold for parties retaining ballot access by requiring candidates receive 10 percent of the vote in the previous general election.
An amendment Springer later added to his own bill reduced the ballot access threshold to 2 percent of the vote in the previous five general elections. Springer said its purpose was not to impact election results but to bring more voices to the table.
The biggest effect is the fact that you have another voice that is pushing ideas during the campaigning process, Springer said. Democrats and Republicans have to factor those policies into what theyre doing; I think that helps the whole process.
Of the presidential races that Paolino studied, third-party candidates did guide presidential priorities in some cases, such as in 1992, when Ross Perot took 19 percent of the vote, the most won by any independent or third-party candidate since former president Theodore Roosevelt in 1912.
Perots campaign about the dangers of the deficit did create some motivation for the two major parties to think about ways to reduce the deficit and ultimately, as we saw by the end of Clinton administration, produced a surplus, Paolino said. Its the idea that if 19 percent of the voters out there might be concerned with this, then its going to be better if we can show were doing something about it.
While Libertarians success in Texas has mostly been in local elections, Bilyeu said she still thinks the direction at the Legislature has been influenced by the partys platform, including its advocacy for marijuana legalization. The Legislature added several more conditions to the states medical marijuana program in its most recent session.
We are impacting elections one way or another, whether were covering the spread (between Democrats and Republicans) or not, because were getting messages out there that would not be heard otherwise and were putting candidates from these old parties on notice, Bilyeu said.
For subscribers: Libertarian, Green parties sue Texas over ballot requirements
Ballot-access battle
The Texas Libertarian and Green parties, as well as other minor party groups and some individuals, in July sued the state over its ballot requirements, including those imposed in Springers bill.
They argue that ballot access requirements one of which calls for them to track down thousands of voters who did not cast ballots in a primary election and get their signatures create a financial barrier to candidates. A federal judge denied the states motion to dismiss the suit Monday but declined to temporarily block the requirements.
Also on Monday, House Speaker Dennis Bonnen requested that the Committee on Elections during the interim period until lawmakers next meet in 2021 monitor the bill, among others, to ensure intended legislative outcome.
Espinoza, the Libertarian candidate in the 2018 race won by Stickland, said laws that restrict third-party ballot access wont prevent them from spreading their message and getting through to voters.
You can do all the political posturing you want to, but if the public does not see the change they want, thats not going to matter, Espinoza said. Theyre going to try to vote for someone outside the two-party system whos going to do what they say theyre going to do and enhance the individual freedoms of each voter.
Data reporter Stephanie Lamm contributed to this report. taylor.goldenstein@chron.com
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As Texas elections get tighter, more third-party candidates are making inroads - Houston Chronicle
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Dr. Anthony Fauci: The anti-vaxx movement is ‘libertarianism taken to the extreme’ – GZERO Media
Posted: at 10:27 am
There are close to 7,000 languages spoken around the world today. Yet, sadly, every two weeks a language dies with its last speaker, and it is predicted that between 50% and 90% of endangered languages will disappear by next century. When a community loses a language, it loses its connection to the past and part of its present. It loses a piece of its identity. As Microsoft thinks about protecting this heritage and the importance of preserving language, it believes that new technology can help.
For the past 14 years, Microsoft has been collaborating with te reo Mori experts and Te Taura Whiri i te Reo Mori (the Mori Language Commission) to weave te reo Mori into the technology that thousands of Kiwis use every day with the goal of ensuring it remains a living language with a strong future. The collaboration has already resulted in translations of Minecraft educational resources and it recently commissioned a game immersed entirely in the traditional Mori world, Ng Motu (The Islands).
Read More at Microsoft On The Issues.
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Dr. Anthony Fauci: The anti-vaxx movement is 'libertarianism taken to the extreme' - GZERO Media
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DeSantis is reshaping Floridas courts with the Federalist Societys help – Tampa Bay Times
Posted: at 10:27 am
TALLAHASSEE Florida Gov. Ron DeSantis was in his element when he gave the opening speech last month at the national convention of the Federalist Society, the organization of conservative and libertarian lawyers.
Citing Federalist papers and 162-year-old U.S. Supreme Court cases, the Harvard-trained attorney made an articulate case against the branch of government he said felt superior to the others.
I think judicial power is too robust right now, DeSantis said. And I think the checks upon it are just simply inadequate.
Less than a year after taking office, DeSantis is faced with making his fourth and fifth picks for the state Supreme Court, melding Floridas highest court to his legal philosophy.
And his views are indistinguishable from the Federalist Society, whose members have been instrumental in making those picks. Leonard Leo, the societys executive director, vetted the three nominees DeSantis made earlier this year.
Two of those judges were later chosen by President Donald Trump for the federal bench meaning DeSantis gets two more Supreme Court picks, likely naming them early next year.
At the convention, Leo said he already knew who DeSantis will choose to replace them: committed Floridian originalists, referring to the originalist judicial philosophy popularized by the organizations most revered member former U.S. Supreme Court Justice Antonin Scalia.
The philosophy goes like this: When reading the law, judges should interpret it as its written on the page. If the law is messy or unclear as it often is judges should not strain to come up with their own interpretations, or rely on what lawmakers might have intended.
That goes for the Constitution as well. The Constitution is not a document that can be interpreted to apply to 21st century problems, as many judges do.
***
Reshaping the court has long been the goal of Republicans in Tallahassee. Since the GOP controlled the governors mansion and the Legislature for the past two decades, only the Supreme Court has checked its power, blocking top priorities from school vouchers to redistricting.
After DeSantis was elected, he got to replace the three justices who were appointed by Democratic governors, and some believe Floridas high court is now among the most conservative in the country.
But in his zeal to reshape the courts, DeSantis, or his staff, has been accused of injecting politics into the judicial selection process.
Attorney Alan Landman, a former head of a judicial circuit nominating commission for the Florida judicial circuit court covering Brevard and Seminole counties, quit this year after he said DeSantis staff asked his to nominate a particular person a lawyer who was a member of the Federalist Society to the bench.
Landman said it was highly inappropriate, and that it had never happened when he served under Gov. Rick Scott for eight years.
When I served (members of the governors staff) never, never stepped into the (judicial nominating) process, Landman said. Never, never.
And former judges and lawyers were alarmed when DeSantis general counsel, Joe Jacquot, asked the chief judge of the Division of Administrative Hearings to step down. DeSantis appointed one of his own lawyers, a Federalist Society chapter president who had virtually no experience in the courtroom.
Last year, Floridas Supreme Court judicial nominating commission stocked with Federalist Society members failed to recommend a single person who was black to the bench, leaving the high court without a black justice for the first time in decades.
Black lawyers are already underrepresented in the legal profession, and there is no guarantee that DeSantis fourth or fifth nominations will be black.
For Eugene Pettis, the first black president of the Florida Bar, the oversight is unthinkable.
To be in the State of Florida and have five appointments and not one of them is African-American? Pettis said. I cannot believe that will happen.
DeSantis spokeswoman Helen Ferr did not say whether DeSantis was committed to appointing a black justice.
Governor DeSantis expects the (commission) to send the best judicial recommendations that focus on candidates who understand the rule of law and the important but limited role of the judiciary, she said in an email. Respect for the Constitution is imperative.
***
The Federalist Society and its philosophy has been popular with Florida governors going back to Jeb Bush, but it hasnt had such an ardent fan in the governors mansion until DeSantis.
He was a member of the society while at Harvard, and hes able to explain his support for originalist philosophy to laymen or lawyers. At the convention last month, he derided judges who didnt subscribe to it.
You have to have some objective measure to go by, DeSantis said at last months convention. It cant just be fly-by-the-seat-of-your-pants philosophizing and imposing whatever idiosyncratic views you have on society under the guise of constitutional interpretation. Originalism provides a mechanism to (restrain) judicial discretion, which I think is very, very important.
By its nature, it means that judges should have less power to strike down laws passed by the Legislature or Congress.
DeSantis last month recounted the Supreme Courts 1857 decision in Dred Scott vs. Sandford, in which the court ruled that black people were not intended to be included under the word citizens in the Constitution. DeSantis called it one of the worst cases the Supreme Court ever decided."
The courts chief justice cited state and local laws at the time the Constitution was created to state that black people and white people were supposed to be separated the kind of legal logic that would rankle originalists.
On the other hand, critics believe some members want to use the philosophy to overturn Roe vs. Wade and weigh in on other social issues.
While the Federalist Society is nonpartisan, its dominated by conservatives and libertarians, and Trump has drawn on its members and their advice to fill federal court seats. Bob Jarvis, a professor of law at Nova Southeastern University, said their philosophy was just a fig leaf for conservatism.
I would disagree with the characterization that theyre not partisan, Jarvis said. Theyre highly partisan.
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DeSantis is reshaping Floridas courts with the Federalist Societys help - Tampa Bay Times
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Scientists Discover Structure of Mysterious Protein Central to the Functioning of DNA – SciTechDaily
Posted: at 10:25 am
A visualization of the FACT protein. Credit: Liu et al. 2019
Researchers have discovered the structure of the FACT proteina mysterious protein central to the functioning of DNA.
Its long been known that the proteins that package DNA, like students at a high school dance, require a chaperone. But what exactly that guardian looks and acts like has been a mysteryuntil now.
A team of researchers at the University of Colorado Boulder has cracked the puzzle of the Facilitates Chromatin Transcription (FACT) protein structure. This protein is partly responsible for making sure everything goes smoothly and no improper interactions take place when DNA temporarily sheds and replaces its guardian proteins, or histones.
These findings, which are the result of a project five years in the making at CU Boulder and out today in the journal Nature, will have ripple effects for not only our understanding of the genome and gene transcription, but for our understanding of cancer and the development of anti-cancer drugs.
This is just the start for this protein. Its not the end, said Yang Liu, a research associate in the Department of Biochemistry at CU Boulder and one of the studys lead authors.
Ever since its discovery in 1998, the FACT protein has been of great interest for those who study DNA, largely because of the possibilities it presents. But, despite decades of effort, many of the central questions of how the protein works remain unanswered.
The FACT protein is an essential type of histone chaperone. These guardian proteins escort other proteins during the deconstruction and reconstruction of nucleosomes, or the structural unit responsible for organizing and packaging DNA. This happens during gene transcription (the step where DNA is copied into RNA), DNA replication (where the entire genome is replicated faithfully) and DNA damage repair (which is essential to prevent disease such as cancer).
However, with no clear structure for the protein available, scientists have been less than clear as to how exactly it does both: How does one protein both destroy and maintain?
This new research sheds light on both.
For a long time, people have been trying to find the mechanism behind how [this protein] helps transcription, said Keda Zhou, a research associate in biochemistry at CU Boulder and the other lead author for the paper. People have been working on different aspects of this protein, so were really happy that were the first to see it in action. Its really exciting.
The research team, aided by two other labs also led by women also managed to finally solve the puzzle by isolating the FACT protein and, through a combination of hard-work, ingenuity and tenacity, map it out and catch it in the act of both destroying and maintaining the nucleosome.
What they found is that FACT resembles the saddle and fork of a unicycle, made up of multiple domains that straddle the nucleosome wheel of the unicycle. Up until that point, researchers were seeing only one domain at a time, causing confusion and contradictory results.
And yet, it appears that none of those differing findings are wrong.
Liu and Zhous work really put everything together. And it seems like everybodys right, which is just really cool, said Karolin Luger, the endowed chair of biochemistry at CU Boulder, a Howard Hughes Medical Institute Investigator and the studys senior author.
This discovery is only the beginning for this protein, both for Lugers lab and the broader medical community.
There are lots of unknowns, said Zhou. But this is a starting point.
###
Reference: FACT caught in the act of manipulating the nucleosome by Yang Liu, Keda Zhou, Naifu Zhang, Hui Wei, Yong Zi Tan, Zhening Zhang, Bridget Carragher, Clinton S. Potter, Sheena DArcy and Karolin Luger, 27 November 2019, Nature.DOI: 10.1038/s41586-019-1820-0
Other coauthors on the new study include researchers at the University of Texas at Dallas, National Resource for Automated Molecular Microscopy and Columbia University.
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DNAs Elusive Chaperone Is Caught in the Act – Technology Networks
Posted: at 10:25 am
It's long been known that the proteins that package DNA, like students at a high school dance, require a chaperone. But what exactly that guardian looks and acts like has been a mystery--until now.
A team of researchers at the University of Colorado Boulder has cracked the puzzle of the Facilitates Chromatin Transcription (FACT) protein structure. This protein is partly responsible for making sure everything goes smoothly and no improper interactions take place when DNA temporarily sheds and replaces its guardian proteins, or histones.
These findings, which are the result of a project five years in the making at CU Boulder and out today in the journalNature, will have ripple effects for not only our understanding of the genome and gene transcription, but for our understanding of cancer and the development of anti-cancer drugs.
"This is just the start for this protein. It's not the end," said Yang Liu, a research associate in the Department of Biochemistry at CU Boulder and one of the study's lead authors.
Ever since its discovery in 1998, the FACT protein has been of great interest for those who study DNA, largely because of the possibilities it presents. But, despite decades of effort, many of the central questions of how the protein works remain unanswered.
The FACT protein is an essential type of histone chaperone. These guardian proteins escort other proteins during the deconstruction and reconstruction of nucleosomes, or the structural unit responsible for organizing and packaging DNA. This happens during gene transcription (the step where DNA is copied into RNA), DNA replication (where the entire genome is replicated faithfully) and DNA damage repair (which is essential to prevent disease such as cancer).
However, with no clear structure for the protein available, scientists have been less than clear as to how exactly it does both: How does one protein both destroy and maintain?
This new research sheds light on both.
"For a long time, people have been trying to find the mechanism behind how [this protein] helps transcription," said Keda Zhou, a research associate in biochemistry at CU Boulder and the other lead author for the paper. "People have been working on different aspects of this protein, so we're really happy that we're the first to see it in action. It's really exciting."
The research team, aided by two other labs also led by women also managed to finally solve the puzzle by isolating the FACT protein and, through a combination of hard-work, ingenuity and tenacity, map it out and catch it in the act of both destroying and maintaining the nucleosome.
What they found is that FACT resembles the saddle and fork of a unicycle, made up of multiple domains that straddle the nucleosome 'wheel' of the unicycle. Up until that point, researchers were seeing only one domain at a time, causing confusion and contradictory results.
And yet, it appears that none of those differing findings are wrong.
Liu and Zhou's work "really put everything together. And it seems like everybody's right, which is just really cool," said Karolin Luger, the endowed chair of biochemistry at CU Boulder, a Howard Hughes Medical Institute Investigator and the study's senior author.
This discovery is only the beginning for this protein, both for Luger's lab and the broader medical community.
"There are lots of unknowns," said Zhou. "But this is a starting point."
Reference: Liu et al. 2019.FACT caught in the act of manipulating the nucleosome. Nature.DOI:https://doi.org/10.1038/s41586-019-1820-0.
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.
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DNA Test Leads To Thanksgiving Reunion 37 Years In The Making – CBS Denver
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DENVER, Colo. (CBS4) A father and his son spent Thanksgiving together for the first time in 37 years thanks to DNA testing from 23 And Me. Casper Collins and Tom Robertson didnt know of each others existence until a positive match connected the two through DNA testing.
Collins was raised by a Filipino single mother after his father, an American Navy sailor, returned to the United States unaware of her pregnancy. Collins was raised knowing his father was an American sailor, but unaware of his identity.
Collins submitted his DNA sample to the company in hope of finding out what medical issues he could be exposed to through his genetics.
I just thought there is no way I am going to find [my father]. But, maybe I would find if I have type two diabetes or something coming up, Collins said.
When the results returned, Collins was matched as a sibling with a man named Michael Robertson in Colorado, who had also submitted his sample to the database. After reaching out, and connecting the dots, Collins confirmed he had found his father.
I was just shaken to the core. Like, this is not real, Collins said.
I didnt have a clue [I had another son], Tom Robertson told CBS4s Dillon Thomas. Im very thankful.
Collins said he didnt have ill-will for his father not being in his life. He said his mother simply lost touch with Robertson.
It was the 80s. There was no Facebook or MySpace, or cell phones, Collins said.
Collins was provided photos of Tom Robertson, and that was when he started to piece together his similarities.
To realize I have kind of been looking at him in the mirror my entire life is just mind blowing, Collins said.
I dont know what I missed out on. I missed a lot of Christmases and birthdays, Tom Robertson said.
However, on Thanksgiving Day, Robertson was able to meet the child he never knew he had. The duo met at Denver International Airport for the first time when Collins visited Colorado for Thanksgiving with his new family.
[It has been] a lot of years, son. I love you, Tom Robertson said as he hugged his son for the first time.
Both Collins, and Robertson, were crying as they embraced each other for an extended period of time.
To feel the love that I was feeling for him, just coming right back, was absolutely amazing, Collins said.
Collins was also able to meet his brother, and other members of his new family.
We always get to see family we didnt see the rest of the year [on Thanksgiving]. Now, we get to see family we havent seen our whole lives. It is extra special this year, Michael Roberts said.
When asked if he would change history if he was able to, Collins said he would leave it the same. With how his life played out he said he was able to have double the friends, double the family and double the places to call home.
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