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Category Archives: Transhuman News

Everyday Heroes who inspire honored by Desert AIDS Project – The Desert Sun

Posted: December 13, 2019 at 3:00 pm

Dane Koch presented an award to Everyday Hero John Bingle Thompson .(Photo: Lani Garfield, Special to The Desert Sun)

Desert AIDS Project (DAP) held its 6th annual Everyday Heroes event on Dec. 1 at the Palm Springs Cultural Center to shine a spotlight on everyday individuals who inspire others.

CEO David Brinkman said he believes Everyday Heroes connects deeply to the humanitarian work of DAP because each of the honorees, in their own way, helps DAP do the work it does to remove roadblocks to human potential. The work of each of the honorees is heroic and deserves the type of recognition traditionally reserved for major philanthropists in the Coachella Valley.

Steve Kaufer, DAP board chair, opened the program to the standing-room-only auditorium, announcing that Everyday Heroes was born to honor the work of local individuals who, through their kindness and compassion, inspire us all. Kaufer reminded the audience that DAP serves more than 7,000 clients and provides 426 people with housing. And during the 2018-2019 fiscal year, DAPtested more than 2,784 people for HIVand more than 1,349 for Hepatitis C. On-site medical teams provided 5,354 dental visits and 7,160 behavioral health sessions.

Dane Koch, DAPs director of retail, introduced John Bingle Thompson, recipient of the Everyday Heroes award for his commitment to the Revivals retail store as a volunteer since 2015. I choose to volunteer at DAP because I, like most of us here tonight, have lost friends and family to HIV/AIDS, Thompson said as he accepted the award.

Everyday Hero Fiona Foyston seemed genuinely moved by being honored.(Photo: Lani Garfield, Special to The Desert Sun)

Ann Sheffer, co-chair and DAP board member, recognized Fiona Foyston for volunteering at DAP and other local organizations. She quoted Mahatma Gandi who said, The best way to find yourself is to lose yourself in the service of others.Foyston accepted the award by recognizing her grandfather, who instilled in her at an early age to be non-judgmental and to accept everyone as they are. If you want to give your little ones a unique gift, Foyston concluded, introduce them to the worthwhile adventures they can experience by helping others.

Everyday Hero Brett Klein talked about aging with HIV.(Photo: Lani Garfield, Special to The Desert Sun)

Co-chair Tom Truhe introduced Brett Klein, who was recognized for his engagement with and leadership roles in the local LGBT communities and HIV+Aging Research Project. Having lived with HIV for 27 years, he noted how he has become keenly aware of the immense need to understand and explore how aging with HIV can affect your body, mind, soul and healthy longevity.

Molly Bondhus and Wil Stiles were presented the first-ever Barbara Keller Community Action Award.(Photo: Lani Garfield, Special to The Desert Sun)

Co-chair and DAP board member Terri Ketover presented the first-ever Barbara Keller Community Action Award to local retail fashion iconsMolly Bondhus and Wil Stiles.

Molly and Wil are two of the most authentic people I have ever met, Ketover said, and their commitment to justice and humanity is unmatched. Bondhus and Stiles celebrated their boutiques 10th anniversary by donating $500,000 worth of new fashion to Revivals Stores to raise funds for DAP.

Truhe concluded the program by thanking his co-chairs Ketover and Sheffer, and DAPs major and event sponsors Steve Tobin and The Grace Helen Spearman Foundation, GileadSciences, Ann Sheffer and Bill Scheffler, Mike Williams and Canyon Pacific Insurance, Contempo Lending, Lulu California Bistro, News Channel 3 and KESQ, Palm Springs Cultural Center, Gay Desert Guide, The Standard Magazine, Leslie Barclays from Diageo Spirits and Smirnoff, Momentous Events, Promo Homo.TV, CV Independent, Hohn Paschal Photography and The Desert Sun.

At the afterparty, where refreshments weredonated by Jerry Keller and Lulu California Bistro, Willie Rhine, recipient of an Everyday Heroes award in 2018,shared that he appreciates DAP for honoring deserving community members who give back to their community quietly, volunteering their time without fanfare.

Susan Stein, Dr. Oscar Chamudes and Tom Truhe met up under the tent.(Photo: Lani Garfield, Special to The Desert Sun)

Among the community leaders enjoying the evening: former Senator Barbara Boxer, Donna MacMillan, Dr. Les Zendel, David Zippel and Michael Johnston, David Perez, Tom Oliver and Matthew Stocker, Jeffery Bernstein and Dr. Oscar Chamudes, Jeffrey Norman, Tad Green and Ed McBride, Lynn Hammond, Julie Makinen, Ellen Wolf, Gayle Hodges and Art Wedmore, Paul Clowers and Frank Goldstin, Andy Linsky, Kevin Bass, Stuart Leviton and Herb Schultz, Susan Stein, Jerry Keller, Brian Wanzek, Renee Glickman, Dennis Flaig-Moore, Albert Gonzalez and Rhine.

Khalil Gibran in "The Prophet" said it best: You give but little when you give of your possessions. It is when you give of yourself that you truly give.

Al Jones currently serves as chairman of the Palm Springs International Airport Commission, on the Desert AIDS Project Partners for Life Leadership Committee and on the CSU Palm Desert Campus Advancement Board. He is also an Allegro member of the Palm Springs Opera Guild and a former board member of Sanctuary Palm Springs and The LGBTQ Community Center of the Desert.

6th annual Everyday Heroes Awards 2019

Sunday, Dec. 1

Palm Springs Cultural Center

Benefiting Desert AIDS Project, 1695 N. Sunrise Way, Palm Springs

How to help: To donate or volunteer, call (760) 323-2118 or email info@desertaidsproject.org

Read or Share this story: https://www.desertsun.com/story/life/2019/12/13/everyday-heroes-honored-palm-springs-desert-aids-project/4380509002/

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Everyday Heroes who inspire honored by Desert AIDS Project - The Desert Sun

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Anti-Senescence Therapy Market Share Analysis and Research Report by 2025 – News by aeresearch

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Benny and Josh Safdie on the Alternate History of Uncut Gems – Vulture

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The Safdies brothers explain their new movies title: Am I non-judgemental? Yes, that means my gems are uncut. Am I on edge? Yes, my gems are uncut. Do I have depth underneath the surface? Yes, my gems are uncut. Photo: Julia Cervantes/A24

Theres a certain rhythm to Uncut Gems and the way it reaches for things for basketball, for jewels, for wins and losses, for takeout from Smith & Wollensky. It revels in its own excess: every single character is talking at once, trying to buy or sell or cut a deal. Its the Diamond District in 2012 when our hero, Howard Ratner (Adam Sandler), is trying to play the part of 47th Streets slickest salesman. A pack of debt collectors are on his trail, but he compulsively romantically, maniacally keeps placing bets. When a middleman walks NBA power forward Kevin Garnett into Howards jewelry store, every moment after feels like a miracle and a curse all at once. Will Kevin come back with the black opal Howard loaned him as a token of good luck? If Howard can auction it off, is it worth as much as he says? Whats the Weeknd doing here?

Gems directors, the Safdie brothers Benny, 33, and Josh, 35 talk like the movies they make: theyll jump up to act out a story or pull out a cell phone to show a photo, speaking fast and a lot as they try to keep up with their next thought. A question about a set can easily prompt an erratic anecdote about the time they walked in on some guy curing meat in a random building in midtown Manhattan. I believe them when they tell me that they rewrote their movie several times, first basing Howards saga around Amare Stoudemire, then Kobe Bryant, and then Joel Embiid, before finally landing on Garnett. Each time, the story of an impossibly lucky gem was reimagined to fit the particulars of each NBA stars career. All of this is a box we put ourselves into, Benny says. We say, Oh we had to do this, we had to do that. We didnt actually have to shoot with a real basketball player and use real games, we chose to. Throughout the course of a conversation with Vulture, the brothers discuss their alternate Uncut Gems plots, the real-life Diamond District figures they befriended, and, of course, what the name of their movie even means.

Josh Safdie: I was trying to explain the whole gems uncut, cut my gems thing to someone. They were like, I dont get it. I was like, Well, this is my take on it. You want to know my take on it?

Hunter Harris: Yes.JS: I want to know your take on it first.

No, no, no. Im interviewing you, I want to hear what you guys have to say.JS: Heres my take on it Am I non-judgmental? Yes, that means my gems are uncut. Am I on edge? Yes, my gems are uncut. Do I have depth underneath the surface? Yes, my gems are uncut. If my gems are cut, Im like naked, ready to be seen. Im potentially dangerous. Uncut is very dangerous, but cut is extra dangerous, because it can have a sharp point. My value is hidden if my gems are uncut, so I have a deeper, bigger value. I might be a little flawed, but Im worth it. Thats gems uncut.

Ah, I see.JS: Ultimately I think its just a very fun play on words, but also, I think its deep. And yes, my gems are uncut.

Benny Safdie: Its also, like, Who are you to cut my gems?

Sort of, Have you no decency? Benny, the last time we spoke, you said that you thought of Howard as literally an uncut gem.BS: The idea is that hes rough on the outside, but if you scratched below the surface, you see the beauty, and you see these things that you didnt quite know were there at first glance. You need to understand him to really love and know who he is.

JS: To me, Howard being an uncut gem is like a corollary to the movie being a radical humanist film, which is kind of in a weird way, all of our movies. Our entire life weve grown up with very flawed people around us, and weve had to see past those flaws, or excuse them, to get at something that makes them relatable, or human, or worthy of value. In the jewelry trade, uncut gems are major gambles. You have to be a genius with your eye to find one [that is actually valuable].

BS: Its not easy to do. If you look at a flawed person and try to see who and what it is that makes them interesting, you learn more about people in general. If you see a stand-up person, sometimes that can make you feel a little bit uncomfortable. Its like, Oh, Im not that good. So if you see somebody who has flaws or issues, it reflects back on humanity in a bigger way.

Theres something else that just popped in my head: if you take a diamond, and its like a rough

JS: I hate diamonds.

Josh, why do you hate diamonds?JS: I mean, look, when you see an IF diamond an internally flawless diamond the purity of it is remarkable: Wow, that actually exists. Its beautiful to see a solid take the form of a liquid with a diamond. That is beautiful. But its the general PR huckster-ism of the diamond industry. Diamonds arent rare. Ultimately, theyre kind of boring Ill take an Indian Star sapphire any day over a diamond. Ill even take like, a cats eye. But like opals in general I mean, a pigeons blood ruby, whoa.

Why opals, specifically, for this movie?JS: Very early on, when we were deciding on which stone should be in the film, it happened to have been right when Ethiopia started to publicize their black opals. It was a big moment in the geological world. The Australians, who are known for their black opals, were actually really pissed about it. Theyre like, Uh-oh, we cant corner the market anymore, so they started an anti-Ethiopia PR campaign. And, sadly, the Ethiopian opals didnt have longevity to them. They started to craze and crack, they were less valuable, which was unfortunate.

JS: White opals are very unlucky, but the black opals are very lucky. And theyre brilliant. You can see the color in them. And they dont have the superstition against them that white opals have.

BS: Some people are afraid of them.

JS: Not black opals, no.

BS: Really?

JS: Well theres a stigma against opals in general, but people who know gems and energies and things, the black opal is an exceptional gem.

BS: But there is something to this idea that people can be afraid of a gem, afraid of an opal.

JS: White opals are predominantly very unlucky, yes. Particularly the Italians, they fucking hate them. They wont go near them. But, the black opal was considered the antithesis of the white opal. Theres a specific color pattern to a black opal its called the harlequin pattern, which is like the most valuable color pattern. Anyway, thats why I prefer a black opal to a diamond.

I want to talk about basketball. Were there other NBA players you reached out to, before Kevin?JS: It started with Amare Stoudemire, who was a Knicks player in 2010. Thats when we started the project. Hes famously a Black Jewish person, so the themes of the movie presented themselves in that way: Ethiopian Jewish tribe. Beta Israelites. Black opals, which were found by a Jewish tribe in the Beta Israelites in Welo mines. Amare is a very spiritual person. He calls himself the spiritual gangster.

But about 20152016, we were having trouble getting financing, finding the right person to star as Howard, and our agency suggested casting up and going with Kobe Bryant. But Kobe they didnt understand the themes of the movie. Hes a West Coast person, we needed East Coast games. Because we had to write around the reality of the games.

Sure.JS: But then I was like, You know what? Theres this one game at the Garden that Kobe dropped 60 points. Lets make that the gem game. And the gem will become a youth elixir, and [the movie will] be about reminding everybody whos the man. In that version, Howards like trying to reclaim his initial win. And, so then we spent two weeks rewriting the whole script, changing the vibe and the themes of the film.

Around Kobe?JS: Around Kobe. And then our agents are like, No, no, no. He doesnt want to act anymore. He wants to direct. And Id just spent two weeks fucking writing this thing! Hes like, Yeah, were not going to send it to him. I was like, What the fuck?!

So then we ended up with Joel Embiid. Because we were like, You know what, were going to update the movie. Its going to be a contemporary film. You want to use a contemporary player. And Joel Embiid presented himself. Before he was even playing in the NBA, he was a legendary Twitter user. He trolled Rihanna. Hes amazing. Hilarious, you know what I mean? And, so I was like, He could be interesting. He could play into the comedy of the film, because his humor is dry and droll. We ended up meeting him through his manager, and his manager ends up in the film.

Who is the manager in the movie?JS: She plays Kevins manager, Jenny Sachs. This is the way the cosmos works: shes studied psychiatry, and worked at a needle exchange. She weirdly saw Heaven Knows What [the Safdies 2016 film]. No one in the sports world saw Heaven Knows What, but she did. She was like vouching for us to Joel, and then we became friends with Joel. And I started going to the Sixers games, and working with Joel, and understanding. Then the themes of the movie became even more overt, with an African player. I was just like, Oh, this is about reclamation, this is about being empowered by reclamation. Joel was into that, things were moving. Now this is the Joel Embiid movie.

When I was writing the scenes, I would send them to Joel. Joel would read them, but mostly Jenny would be like, I dont know if he can do that. I dont know if this is too much. This scene might be too much to ask of him. I got a little nervous about that. But in the end, I knew he was such a cocky guy that it would have been fine. And then the schedule pushed into the NBA season, and we couldnt use an active player. So then we had a list of other players who were recently retired. We went back to Amare.

BS: The list wasnt like this [gestures widely] long.

JS: Amare wouldnt shave his head to match the games that we had to cut in between.

BS: But the thing is [laughs] all of this is a box we put ourselves into. We say, Oh we had to do this, we had to do that. We didnt actually have to shoot with a real basketball player and use real games, we chose to because

JS: We did have to.

Because how else do you make this movie?BS: Thats the point! But everybodys, Oh, just cast an actor.

JS: Someone did try to push that on us.

BS: Really, that is an idea that was put out there. Im like, Maybe you dont understand. Having a real player, and having a player act, and then using those real games on the television creates a good alchemy.

JS: Once we saw the new list [of available retired players], Kevin Garnetts name was on it. As a Knicks fan, I was so, like, We cant put Kevin Garnett in the movie. I hate him. But that was when my film intelligence was kind of eclipsed by my insane, schizophrenic, Knicks fandom, where I actually couldnt see past what I normally would have realized, which was that me hating Garnett is actually a testament to his incredible acting ability, and how he plays a great heel in the NBA. He can get people to despise him, based on his performance on a nightly basis of 20,000 people.

BS: And when we were talking to him, just the way that he told stories Id never seen anything like it before. He would set you up in the room, show you where people were sitting, who was behind him, the noises that were happening, the way the door closed.

JS: Put it this way, he sweats when he tells a story You have to remember, hes a superstar. He went from high school to the pros.

BS: He kind of underplays [his performance in Uncut Gems], like, Oh, I was just playing myself. I was just playing myself. Thats a very difficult thing to do, because you have to be comfortable.

JS: Hes playing the self that he created for the NBA.

Adam Sandler as Howard, wet and beaten in New York City, in a scene from Uncut Gems. Photo: Julia Cervantes/A24

So tell me more about the Diamond District, and re-creating this world that feels at once very alive but also hermetically sealed. How did you make that happen, particularly when Howards actual shop was built on a soundstage, right?BS: For us, it was actually hard because we like to shoot on location all the time. To do that on a stage was out of necessity. We couldnt physically shoot in a real jewelers place. We wouldnt have had a lease long enough, and getting up and down in these buildings is insane.

JS: The lease wasnt the problem.

BS: No, it was mainly just getting in and out of [a jewelers shop]. Theres a certain amount of elevators, and theres so many people going up and down all the time. We wouldnt have been able to get all the stuff in there to build it out. We had this whole idea that people would be coming into work on the district, they would kind of breathe this energy. So, once we moved into a stage, its like: How do we re-create that feeling, that vibe? By bringing a bunch of people there who worked in the district that are in the movie. Sometimes they werent even in the scene, but we had them there just to kind of breathe the energy.

JS: To me, the first major compromise of the film was agreeing to shoot the business on a soundstage. And by the business, I mean his showroom, his back room, the hallway, the elevator bays.

BS: But, for [the shoots that did take place on the streets of the Diamond District], we really wanted to capture the district as it was, kind of unfettered from us. Even though we were having a footprint there, we didnt want to disturb it. We kept it open, which you have to. Legally youre not allowed to close the street, because its business. We embraced that fully. Theres people just walking in and out of the frames, all the time.

JS: In 2012, after the first nostalgic draft was finished, I went and started to involve myself deep in the research in the Diamond District. Its a very consumers materialist world me not being able to buy anything there was actually like a major inhibitor of getting deep in with anyone.

So howd you do it?JS: I had to bring press clippings in, and try to prove that I was a real filmmaker. And, over time, those clippings became a little bit more impressive. Two years into my research, we made a documentary about a basketball player

This is Lenny Cooke?JS: Yeah, that reached the Diamond District crowd. They do a lot of business with athletes, and a lot of athletes were talking about the movie. They also stay on WorldStarHipHop, and the trailer blew up on WorldStar. I actually brought Lenny to the diamond district once, because he used to go. He went to Jacob the Jeweler. There was a jewelry shop called Rafael and Co., who were very helpful to us in the beginning, letting us see how the business operates. But there was another guy named Joe Rodeo. I had a friend, and the friend has since passed, but he was a real character. He was from New York. His name was Tuna. He loved going there, and making a big show of buying shit from these guys, like a watch, or what have you. Finally I was in, because I was now with someone who was buying stuff. When I got to go to the back rooms, I took photos. I wasnt sure that I was ever going to get back to this specific upstairs spot, because its pretty private. I took so many pictures the first time I went in there. I probably took like a hundred pictures of the weirdest stuff

BS: How about Joe?

JS: This guy. His name isnt even Joe! We met him and someone called him that, and they just went with it for a while. They were just like, Yeah, Joe. It was so strange. Joe owned a building 20 West 47th. His son Alon married into a very big family on 47th street, the Nektalov family. Theres a great New York Magazine piece about Nektalov. Nektalov was murdered on Sixth Avenue. Its a crazy story.

Oh my God.JS: So the Nektalov family is Leon Diamonds, and they were huge on the block. They were very hard to get in with. Richie Nektalov ended up helping [us]. Thats whose Rolls Royce it is in the movie that Judd Hirsch gets into.

BS: Thats Richie Nektalovs house, too, and hes also in the Passover scene.

JS: So, the tentacles were wide, you know? Eventually I got in with Joe and his son Alon. And Joe was very skeptical of us. Like, Who are these guys? Can we make money off of them? And I was just trying to earn my place. They showed us this huge penthouse. When I went up there for the first time, there was a guy curing meat, living on an air mattress. I have pictures of it. This guy had a bunch of meat hanging up from the ceiling.

BS: This is on Sixth Avenue and 47th Street, in the middle of Manhattan! Its unbelievable.

JS: Hes curing meat! Id told them I knew all these interior designers and architects. So hes like, If you can help me turn this into a lounge he had this big vision for it, with a sauna, and all this stuff Ill help you in exchange. So I ended up hiring an architect. I brought in this legendary interior designer, who weirdly has also since passed, Jim Walrod.

And then what happened?JS: I said, Ill do this for you Joe, in exchange for a six-month lease on a space in your building. It was the perfect size, but as Benny was saying, it became very impractical to actually shoot in it.

BS: Once you accept that okay, were not going to do it on location, well do it on the stage, you get to design. The design of [Howards shop] is just crazy to get into the details. We could design parts of the space to be a certain height, based on Kevin Garnetts height. So when he goes in, he looks much bigger.

JS: We made the ceilings about half a foot shorter, to make him look taller.

BS: Basically we have this whole space outfitted to look so real, and yet its totally fabricated. Every light was on its own color temperature, its own brightness. It was the most complicated lighting setup you could possibly have.

JS: This has nothing to do with 47th Street.

BS: It does. Its about capturing the vibe. You literally go so far to fake it, to make it look real.

This interview has been edited and condensed for clarity.

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Benny and Josh Safdie on the Alternate History of Uncut Gems - Vulture

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The wisdom of ancient kitchens – Easy Reader News

Posted: at 3:00 pm

Added on December 12, 2019Mark McDermottManhattan Beach , newsletter

Dan Buettner in the Okinawa blue zone. Photo by Dan McLain/National Geographic

National Geographic explorer Dan Buettner investigates the food and culture of those who live the longest, and comes back with recipes

by Mark McDermott

Most mornings, Cowboy Jose Bonifacio rides his horse Corazn five miles to go see two old friends. Bonifacio is known far and wide as one of the great vaqueros, or cowboys, of the Guanacaste province on the Nicoya Peninsula of Costa Rica. He began riding horses in 1921, at the age of 4. Hes 102 years old. His two friends are both over 100.

Two years ago, National Geographic explorer Dan Buettner went looking for the great cowboy, who hes known for years. Buettner has led several expeditions to the Nicoya Peninsula because it is home to some of the longest living humans on Earth, and longevity has been his area of inquiry for the last decade and a half. Hes written four books and dozens of National Geographic articles about the so-called blue zones, the five areas scattered across the planet where people live the longest. He sought out Bonifacio who is not hard to find, having lived in the same house all his 102 years for his newest book, The Blue Zones Kitchen.

Buettners intentions were simple. He wanted to share a meal with Bonifacio and his family, and take notes. Buettner has spent more time with 100-year-olds, known as centenarians, than anyone on the planet who is not 100. His research has been about the ways of life that lead to the kind of health in which people not only live a century but do so, like Bonifacio, with gusto. Hes examined everything from habits of human connection to physical activity and even the composition of the soil and water in the lands where people live longest, but all these roads lead back to the most fundamental of human activities: sharing a meal. And this is why he found himself back at Bonifacios humble dwelling in Guanacaste.

We arrive early, waiting for him in the cool shade under the 100-year-old mango trees in his courtyard, Buettner writes. He trots up on a horse wearing blue jeans, a checkered shirt, and a jaunty-angled cowboy hat. He dismounts with a bounce and welcomes us warmly with a handshake and a half toothed smile. Hes lived in the same house his whole life, now with four generations of descendants. At 100, he still recites romantic poems and professes his love of women.

Buettner has spent time with over 300 centenarians, but none cooler than the cowboy, who on this occasion asked his daughter and granddaughter to prepare a special lunch for his visitors, Buettner and famed National Geographic photographer David McLain. The lunch was served in an outdoor kitchen, centered around an oven used by the Chorotega, a tribe of corn farmers who historically were the most powerful of the Native Americans in the region.

Dinner is served in Ikaria. Photo by Dan McLain/National Geographic

They cook over a fogn, which is a Chorortega oven that dates back before the age of Christ, Buettner said in an interview. Its sort of a U-shaped adobe appliance, so to speak, with a wooden fire. So there you are, smelling roasted corn and woodsmoke and the aromaThe beans they are making tend to be more aromatic, with peppers and onions and garlic and cilantro. And its a wooden structure with slats in it, so sunlight is angling through the slats and hitting the floor in long parallel lines, but its sort of beautifully, smokily illuminated on the inside. And you are smelling the same smells that the ancient Maya were smelling in 1,000 B.C.

Lunch was chunky vegetable soup, a veggie hash with corn and onions, hearts of palms with herbs and garlic, creamy lima beans and herbs, and fried green plantains. It was accompanied by mugs of what Buettner described as shockingly refreshing horchata and citrus fresco.

The Blue Zones Kitchen, which includes recipes for each component of the lunch, was released last week and achieved a somewhat unusual feat for what is ostensibly a cookbook: it was the bestselling book in the United States across all categories. The books success shocked even Buettner.

Its surreal, he said. After years and years of these high-minded literary pursuits, I realized what people want are just pretty pictures and a great bean recipe.

The Blue Zones Kitchen isnt like any cookbook ever before published. In it, Buettner visits kitchens in each of the five blue zones: Okinawa, Japan; Ikaria, Greece; Sardinia, Italy; Yorba Linda, California (a Seventh Day Adventist community); and the Nicoya Peninsula, Costa Rica. An earlier book, The Blue Zones Solution, also included recipes, but not presented in this way, with McLains vivid photography showing the physical beauty of the people and the food of blue zones. Its pages emanate with the warmth of human conviviality.

David and I are not cookbook writers. David and I are a writing and photography team for National Geographic, Buettner said. This book is essentially a 300-page National Geographic article, centered around food and recipes. And thats how we approached it. For the recipes, I didnt just go find some other book and copy them; I sat on stools in 80, 90 and 100-year-old womens kitchens, and I watched them. I wrote down fastidiously everything they did. I estimated quantities you know, they dont use cups or teaspoons or any of that crap. I captured these recipes, which by the way will be gone in half a generation.

The recipes from Buettners notebooks were then taken to a test kitchen and proofed out for exact quantities, and now run alongside hundreds of photos taken by McLain, which are also not the typical, prettified pictures usually found in cookbooks.

Not a single picture in the book is shot in a studio, Buettner said. Its all editorial and its all with the gifted David McLain. He shot the ingredients, the setting, the people, the cooking techniques, and then the rituals around it. So its a very different book than a cookbook.

Dan Buettner in the Costa Rica blue zone. Photo by Dan McLain/National Geographic

Buettner is well-known locally because he launched the first Blue Zones Project in the Beach Cities. The projects, which now number over 50 nationwide, are public health initiatives which take the wisdom derived from Buettners studies of actual blue zones and apply lessons programmatically; locally, the Blue Zones Project is administered by the Beach Cities Health District (see last weeks Easy Reader cover story, Tripping Over Health). Buettners central insight is that healthy behavior happens not when we focus on changing behavior, but when the environment in which we live makes healthier choices easier to make.

The Blue Zones Kitchen follows this ethos. Its easy to use. Not one of its 100 recipes requires more than a handful of ingredients. It is peasant food; simple, cheap, easy, and by the way healthy.

Its organized by genres of cooking, Buettner said. There is Greek, from Ikaria; Italian, from Sardinia; Asian, in Okinawa; Latin American, Costa Rica; and American, Loma Linda. So they are easily recognizable categories of food. They are just simple. You can add cheese if you want to some of them, but the quotidian day-to-day eating in blue zones was plant-based. They ate meat, but it was a celebratory food, and I dont need to put a recipe for roasted meat in so all the recipes are plant-based. And they all have the most important ingredient, which is taste. These recipes, theyve been cooked for at least 500 years in most of these places. The reason they survived is not because people think the recipes are healthy. Its because people like them. They are tasty.

Cowboy Jose Bonifacio in Costa Rica. Photo by Dan McLain/National Geographic

Another aspect of the book that sets it apart is its beautiful array of story, science, travel, and cultural exploration. For example, in Costa Rica Buettner found what he believes might be the most perfect breakfast in the world, featuring what locals call the tres hermanas, or three sisters: corn, beans, and squash. He recalls in loving detail enjoying this breakfast in the Cooperativa Nicoya, where a dozen women begin preparation before dawn each morning and people stop by on their way to work. The meal is the locally beloved gallo pinto, rice, and beans with garlic, onions, peppers and squash, served with freshly made tortillas, a vinegar-based hot sauce called chilero, and locally grown coffee.

At 6 a.m., the first customers file in, most of them market vendors or laborers, Buettner writes. They take seats on benches at long green tables. Cooperativa waitresses, wearing simple dresses and flip-flops, serve giant cups of weak local coffee, steaming plates of the gallo pinto, and baskets of warm tortillas. As muddy ranchero music plays from a distant radio, customers fill their tortillas with beans topped with chilero hot sauce. This is arguably the most perfect food combination ever, and for some it brings forth tears of joy.

The meal is perfect because tastes great while providing everything the human body needs for sustenance. The corn tortillas are whole-grain, low glycemic (meaning more slowly digested, absorbed, and metabolized) complex carbohydrates, Buettner reports, noting that the wood ash of the stoves breaks down the corns cell walls, thus making niacin available and freeing amino acids for absorption into the body. The black beans are rich in both antioxidants and fiber, which is colon-cleansing, lowers blood pressure and regulates insulin. Combined with rice, the beans form a perfect protein; the pepper sauce that tops it all off is a probiotic (meaning good for gut health). Even the coffee is rich in antioxidants. The total cost of the breakfast was $4.23.

Buettner writes that this meal is what the poorest people in Costa Rica subsist on. His research partners found that these very people have the longest telomeres the DNA tips that mark biological age of any in Costa Rica. He says their bodies tend to be a decade younger than their age would suggest.

Its really kind of the Zen of eating, Buettner said. Its so simple. Its like great sushi. Most cuisines are additive for example, French cuisine is cream and butter and herbs. Sushi is just beautifully one ingredient. This is three ingredients. Imagine slow-cooked beans; the beans are perfect, kind of al dente, they still have their flavor, they still have the anthocyanins, which are the anti-oxidants you find in blueberries. Add a roasted whole-grain corn tortilla: all it is whole grain corn patted down and roasted. And then some roasted squash. You put the beans in a tortilla, maybe put some hot sauce on it, or in Costa Rica its chilero, and man, you do cry tears of joyIts so easy and so cheap and the stuff is good for a long time.

Buettners blend of storytelling and science is so seamless you dont really realize you are learning. Simplicity is key. Part of this is his sources. We dont live in a time when we often have access to the elders of our tribe, and their practical, well-worn advice, as most previous generations of humanity did. Buettner shared a meal with another centenarian in Costa Rica, a 106-year-old former lumberjack named Jose Guevara.

Hed actually done a good bit of thinking about his longevity and boiled it down to three secrets: Start your day with fruit, eat beans at every meal, and practice absolute honesty, Buettner writes. Words to live by, methinks.

Much of the wisdom that comes from the blue zones is essentially remedial human training: knowledge that was baked into the way people lived for eons before the disruption caused by more modern ways of living.

Its relearning what our grandparents instinctively knew, Buettner said.

Women in Ikiaria work together in the kitchen. Photo by Dan McLain/National Geographic

The links in that chain are mostly unbroken in the blue zones. Generations know each other, and cook together. Meals are shared multi-generationally, and often communally. Some of the recipes in The Blue Zones Kitchen contain varying versions, as each village or family has its own idea of how to do things. The Melis family in Sardinia (nine siblings with a combined age of 852 years) shared their version of minestrone soup, which they told Buettner theyd eaten every day of their life. Another family shared another version.

A 100-year-old cooked me Sardinian minestrone, Buettner said. The rest of her family cooked me other things and then we sat down and drank a good bit of wine, Connoneau, which is almost always an accompaniment with meals there. And then toasts ensue, and you get that sort of perfect combination of familial warmth and alcohol, and theres no better drug.

There is science underlying the warm feeling of this scene. Sardinian minestrone is a pot of healthy amino acids with all the protein a human needs for sustenance along with huge does of fiber and healthy gut bacteria. Its cruciferous vegetablesonions, cabbage, kohlrabiregulate thyroid function, a key to longevity. And even the wine, Connoneau, is particularly flavonoid-rich and brimming with antioxidants. But the biggest factor underlying long-living is the gathering itself.

I didnt set out to try to write a cookbook from the beginning. I realized, though, that the runway for people for a healthier life is often through their mouth, Buettner said. But what makes it work, what makes it stick, and what makes it last is building a meaningful social network, or social circle, around the food. And that is in an almost hormonal senseif you are eating with somebody you like, you have less cortisol interference as compared to eating on the run or eating with some sort of existential stress, and there is a love and a joy in that which I believe adds to longevity. But more important than that, if the people you are running with are also eating largely a whole-food, plant-based diet, its not a chore. You are not getting tempted by the burgers and the baby back ribs and the chips and all the other crap that people gather around.

We are, in fact, genetically hardwired for human interaction. Previous generations of humans could not have fathomed the idea of fast food or how much we eat alone. Another common trait in all blue zones kitchens is they are social places.

We tend to be genetically endowed with a propensity for things that ensure our survival, Buettner said. And humans, unlike so many other mammals that havent been as successful, are eusocial. That weve been successful because we come together as a tribe. We naturally are drawn to each other and we can take on bigger tasks together than we can by ourselves. So to all of sudden fast forward to 2019 when everybody is imploding in their devices maybe for survivability, on its surface, we dont really need other humans. But we still have that genetic yearning for it, and the meal is the natural time to give in to that. Its the natural time to socialize because you are slowing down, you are sitting down.

Research shows that people who eat socially, particularly families, eat more nutritiously than those who eat alone.

Because when you are eating by yourself, it takes about 20 minutes for the full feeling to travel through your belly to your brain, Buettner said. So if you are eating by yourself to your favorite TV show and wolfing down your dinner, theres a very good chance that you will already be full long before your stomach knows it, long before your brain knows it. Conversely, if you are sitting down with four or five friends, you are having a conversation, you are telling jokes, you are laughing, then you take a bite of food you are less likely to overeat.

The biggest piece of advice implicit in the The Blue Zones Kitchen is simply to cook. The benefits are myriad. People in the blue zones, and those who cook in general, tend to rotate between the same 10 or 12 meals. They thus have a more consistent diet, meaning their immune systems dont have to work so hard to always counter different potential threats. A worn-out immune system is one of the things that catches up with us in older age when the body can no longer fight off cancer cells, among other things.

Cook at home. You dont have to buy my book. Theres lots of other books, Buettner said. I hear all the time, Well, I dont have time to cook. And if you take a moment and you think clearly, people who are eating junk food their whole life are probably shaving a decade off their life expectancy. If you take those 10 years and average them back through the rest of your life, youve got about 2.5 hours of a day of time that you could be spending on making good food. And youll have just as many hours in your lifetime. We fail. We get misled by a certain cultural thrust that is wrong.

I think there are a lot of people out there marketing longevity. The Blue Zones kind of genre is not just about getting more, piling on more years, its about quality along the way. Its a holistic look at longevity. And the value proposition is about 14 years. The maximum average life expectancy for humans is about 93 or 94. We are getting about 80 in America right about now, so we are leaving about 13 or 14 years on the table. We could be getting those years by living a blue zone lifestyle. But if you are living with purpose, you are socializing and connecting with friends, you have that faith-based component in place and that could be going to church, it could be going to yoga you are enjoying the journey. Its not just living long. Its living well.

It is, in a sense, the oldest story in the world, and one that is increasingly being forgotten. Buettner said that all the blue zones are increasingly being encroached upon by the disease of convenience. His reporting is documenting ways of life which are disappearing.

Okinawa in 1990 was a fantastically exotic place, and now its a jungle of Pizza Huts and A&W Root Beer. Junk food, Buettner said. Theres only a few little pockets of originality left. Costa Rica theres a damn KFC as you enter the city of Nicoya. And here is this beautiful food tradition that in Nicoya anyway its been around for 5,000 years, the Mesoamerican three sisters of corn, tortilla, beans, and squash. Which are three foods that can wholly sustain you. They are being pushed out by buckets of hormones-suffused chicken and burgers. Just like when they came to America, they are incredibly alluring. They are fast and they are cheap and they are like an orgasm in your mouth when you been used to eating sort of subtle flavors.

His mind drifts frequently to a scene on the coast of Ikaria. A woman named Athina was cooking in a kitchen crowded with women.

She is about 60, and shes been cooking for 50 years, and she learned it from her grandmother who learned it from her grandmother, Buettner said. So sitting on a stool in a tiny kitchen watching her workYou can sort of see the Aegean Sea out the kitchen window and you kind of see 500 years of history unfold. Above your head, there are all these pans, and there is this wonderful cacophony of chopping and pans bubbling and pans clattering and kids running around squealing and these sort of nomadic aromas of sage and oregano and rosemary and olive oil and the pungency of roasting squash. And Im sitting there with a glass of wine, the type of wine that is produced in Ikaria, the Pranos, the same wine that Ulysses gave the cyclops to get him drunk so he could knock him offthey are still drinking that wine in IkariaIts just happiness.

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Master the necessary, do whats possible to build resiliency into your farm – RealAgriculture

Posted: at 3:00 pm

The longevity of a business is less about how well it does in the good times, and more about how it fares through the rough patches. A farm being resilient can come in many forms, but usually comes down to the strength of the management team running it and the financial nimbleness of the overall operation.

Amy Cronin is a hog farmer, Nuffield scholar and leader of an expanding farm business in Ontario, Missouri, and Iowa. Along with her husband and business partner Mike, Cronin Family Farms has a goal of striving to be the best. They may not always get there, Cronin says, but thats the goal.

Our vision at Cronin Family Farms is Progressive. Prosperous. Best in class, she says.

Having navigated through low hog prices, a major business expansion, a barn fire and now taking on a farm diversification project, Cronin says that communicating ahead of these challenges and decisions is key. We needed to have a serious conversation about how we deal with problems. How we dealt with problems was the determining factor on whether we would or would not expand, she says. We decided to look at our problems and an opportunity. When I look back on it, that is building resiliency.

Its this mindset on viewing challenges differently and using them to better themselves and their business that has allowed their farm to navigate hardship. Moving on is important, says Cronin. They choose to face their problems head-on, put them to bed, and move on. And thats part of resiliency, too dealing with things thoroughly and right away. Its important, she says, to deal with what keeps you up at night.

Innovation and diversification also play a key role in the numbers side of the business. But thats not all about technology, its about management and people. Cronin says theyre always looking at ways to do things differently and better, and that could mean adopting a new management style or creating their own way to do something and incorporating that into the business.

Diversification is key to risk management, yes, but Cronin says they also balance business needs with human needs. Labour is a huge part of making everything work, and Cronin recognizes the need to care for themselves so they can lead a dynamic and fantastic team and take care of them, too.

Cronin uses the quote by Francis of Assisi to guide much of what they do. We start by doing whats necessary, then we do whats possible, and soon we can do the impossible, she says. That impossible right now is making pans for their older children coming back to the farm. Whats necessary and now possible is diversifying into the chicken business. Starting with whats necessary and mastering that, means they can then move on to expanding what is possible for their farm.

Hear more from Amy Cronin in conversation with Bern Tobin at the Agricultural Excellence Conference:

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His life in ‘overtime,’ Penn doctor races to find better treatments for rare Castleman disease – PhillyVoice.com

Posted: at 2:51 pm

David Fajgenbaum's life went into overtime the moment a priest read his last rites in November 2010.

At least that's how the Penn Medicine immunologist views his last nine years.

That belief has reshaped the way Fajgenbaum confronts idiopathic multicentric Castleman disease, a rare immune system disorder that has dealt him five life-threatening blows. It's also changed the way he goes about his life.

"When you're in overtime, every second counts. You don't know how much time you have," said Fajgenbaum, a former quarterback at Georgetown University. "It really helps you focus in on what's important and what's not important."

For a while, Fajgenbaum said he "just hoped and prayed" that someone, somewhere, would find a cure and better treatment options for Castleman disease, which kills about 35% of its victims within five years of diagnosis. Then, he realized he might be that person.

That life lesson is among several that Fajgenbaum, 34, recounts in his new memoir, "Chasing My Cure: A Doctor's Race To Turn Hope Into Action." Fajgenbuam wrote the book partly in hopes of boosting awareness of Castleman disease, which has not gained the notoriety of other rare diseases despite its deadly nature.

"We shouldn't either hopeortake action we should hopeandtake action," Fajgenbaum said. "I'm here on the phone because of that turning point."

Idiopathic multicentric Castleman disease the most severe form of the disorder activates the bodys immune system, releasing an abundance of inflammatory proteins that can shut down the liver, kidneys and bone marrow. Relatively little is known about it.

Fajgenbaum, an assistant professor in Penn Medicine's Translational Medicine and Human Genetics division, has spearheaded efforts to identify more effective treatment options for people with Castleman disease. After all, he recognizes his clock may stop ticking at any moment.

Chemotherapy can keep the disease at bay for a while, but it's not a permanent solution, Fajgenbaum said. Patients tend to relapse after treatment, creating a vicious cycle that he knows all too well.

Thus far, the U.S. Food and Drug Administration only has approved one treatment siltuximab for Castleman disease. But it only works in about one-third of patients and Fajgenbaum is not one of them.

Fagjenbaum's research and his personal experience eventually led him to sirolimus, an immunosuppressant typically prescribed for kidney transplant patients. Because the drug inhibits activated T-cells, he suspected it might put his disease in remission.

"I knew if I did not start myself on a drug, there was no way I was going to make it," Fajgenbaum said.

Under the supervision of his doctor, Fajgenbaum began taking sirolimus after his last life-threatening hospitalization six years ago. At the time, Fajgenbaum was simply hoping he'd live long enough to marry his girlfriend, Caitlin something he said he once took for granted.

"The pre-overtime mentality is that we have all the time in the world, that if it's meant to be, it's meant to be," Fajgenbaum said. "But the overtime reality is that none of us have all the time in the world. If it's meaningful and important, then that's exactly what you should do."

Since Fajgenbaum began taking sirolimus, his symptoms have not flared up.

Now, he and Caitlin have a daughter, Amelia. And Fajgenbaum is leading clinical trials examining sirolimus' effectiveness against Castleman disease. Like siltuximab, the drug appears it may help some but not all people battling Castleman disease.

That has Fajgenbaum wondering how many other existing drugs have been overlooked as potential treatments for other diseases. It's another lesson that he expands upon in his book.

"Sometimes, solutions can be hiding in plain site," Fajgenbaum said. "This drug I'm on is in my neighborhood CVS all these years and no one had thought to try it. How many other things are like that ... in science or medicine?"

Since writing the book, Fajgenbaum said he has heard from all kinds of people who have faced challenging health diagnoses, whether it's cancer or some other rare disease.

It's definitely moving the needle, Fajgenbaum said. In September, the month the book was published, more people Googled Castleman disease than ever before. And more people have donated funds to the Castleman Disease Collaborative Network, an organization he co-founded to expedite research efforts.

"It's really been, in many ways, therapeutic to be able to share my story, the ups and the downs," Fajgenbaum said. "Even writing it was therapeutic. To bring back some tough memories, to expose them and to face them."

Sometimes, Fajgenbaum said, it's best to face the tough times with a sense of humor. That's a lesson he gained from his late mother, who died of cancer when he was at Georgetown.

Fajgenbaum recalled flying to Raleigh, North Carolina to see his mother after she had a brain tumor removed. He tentatively walked into her room alongside his family, unsure what to expect. He found his mom sitting, her head shaved and partly covered by a gauze wrap.

She pointed to her head and joked that she looked like the Chiquita banana lady.

"It was exactly what we needed," Fajgenbaum said. "It wasn't what my mom needed. She was going through a really tough time. It wasn't going to make her feel better. But she knew that it was going to make us feel better. By making that joke, it kind of relieved everything. It was like, you're still my mom, you're still you."

A few years later, Fajgenbaum found himself walking around the hospital with his father on New Year's Eve. This time, Fajgenbaum was the patient. His stomach was filled with 30 pounds of fluid, the result of his ill-functioning kidneys and liver.

As they passed the family waiting area, they stopped to help a man who was laying on the floor, noticeably drunk. The man thanked Fajgenbaum's father, wishing him and his "pregnant wife" the best of luck.

"We just burst into laughter," Fajgenbaum said. "I turned to my dad and said, 'Man, you've got an ugly wife.'

"If I hadn't had my mom's example ... maybe I would have just burst into tears and gone back to my room. Rather, that's hilarious. This drunk guy thinks I'm a pregnant woman because of the size of my belly."

That moment, nearly nine years ago, came just several weeks into Fajgenbaum's "overtime" session. He's overcome a lot since and learned a great deal. But he knows there's more work to be done for him and for others.

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The second Indo-Swiss Meeting on Evolutionary Biology begins today – Research Matters

Posted: at 2:51 pm

The Centre for Human Genetics, Bengaluru, is hosting the second edition of the Indo-Swiss Meeting Meeting on Evolutionary Biology, held in India this year. The meeting is jointly organised by the Indian Society of Evolutionary Biologists, Centre for Human Genetics, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) and Swissnex India. The gathering brings together faculty and students from India and Switzerland. The three day meeting begins on the 12th of December and continues until the 14th.

The highlight of the event is the line-up of talks by various researchers from both countries on the topic of evolutionary biology.

We have about a hundred participants registered for the event and we hope to have a great discussion during the three days, said Prof Amitabh Joshi from JNCASR, who is also the coordinator of this event. This meeting, currently in its second edition, hopes to bring increased collaborations between researchers from both the countries, he says.

The presentations during the meeting span a huge spectrum of evolutionary biology, with Principal Investigators and doctoral and postdoctoral students from different institutes, presenting their research to a wider audience.

It feels nice to be here for the second edition of this meeting in India and I am hoping to meet many researchers and network with them, says Dr Rolf Kmmerli, from the University of Zurich. He had attended the first version of the meeting held in Switzerland. This year, the gathering is bigger than last year. he says.

The meeting hosts six talks by Swiss researchers and twelve by senior and early-career Indian evolutionary biologists. There is also a poster presentation and panel discussion organised as a part of the event. Additional details and the information on speakers can be found here.

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Teams of Microbes Are at Work in Our Bodies. Drexel Researchers Have Figured Out What They’re up to. – DrexelNow – Drexel Now

Posted: at 2:51 pm

Drexel researchers have developed an algorithm toolkit that can identify communities of microbes in the human body and determine how they are functioning by finding patterns their genetic code.

An algorithm akin to the annoyingly helpful one that attempts to auto-complete text messages and emails is now being harnessed for a better cause. A group of Drexel University researchers are using its pattern-recognition ability to identify microbial communities in the body by sifting through volumes of genetic code. Their method could speed the development of medical treatments for microbiota-linked ailments like Crohns disease.

In the last decade, scientists have made tremendous progress in understanding that groups of bacteria and viruses that naturally coexist throughout the human body play an important role in some vital functions like digestion, metabolism and even fighting off diseases. But understanding just how they do it remains a question.

Researchers from Drexel are hoping to help answer that question through a clever combination of high-throughput genetic sequencing and natural language processing computer algorithms. Their research, which was recently published in the journal PLOS ONE, reports a new method of analyzing the codes found in RNA that can delineate human microbial communities and reveal how they operate.

Much of the research on the human microbial environment or microbiome has focused on identifying all of the different microbe species. And the nascent development of treatments for microbiota-linked maladies operates under the idea that imbalances or deviations in the microbiome are the source of health problems, such as indigestion or Crohns disease.

But to properly correct these imbalances its important for scientists to have a broader understanding of microbial communities as they exist both in the afflicted areas and throughout the entire body.

We are really just beginning to scrape the surface of understanding the health effects of microbiota, said Gail Rosen, PhD, an associate professor in Drexels College of Engineering, who was an author of the paper. In many ways scientists have jumped into this work without having a full picture of what these microbial communities look like, how prevalent they are and how their internal configuration affects their immediate environment within the human body.

Rosen heads Drexels Center for Biological Discovery from Big Data, a group of researchers that has been applying algorithms and machine learning to help decipher massive amounts of genetic sequencing information that has become available in the last handful of years. Their work and similar efforts around the world have moved microbiology and genetics research from the wet lab to the data center creating a computational approach to studying organism interactions and evolution, called metagenomics.

In this type of research, a scan of a genetic material sample DNA or RNA can be interpreted to reveal the organisms that are likely present. The method presented by Rosens group takes that one step farther by analyzing the genetic code to spot recurring patterns, an indication that certain groups of organisms microbes in this case are found together so frequently that its not a coincidence.

We call this method themetagenomics, because we are looking for recurring themes in microbiomes that are indicators of co-occurring groups of microbes, Rosen said. There are thousands of species of microbes living in the body, so if you think about all the permutations of groupings that could exist you can imagine what a daunting task it is to determine which of them are living in community with each other. Our method puts a pattern-spotting algorithm to work on the task, which saves a tremendous amount of time and eliminates some guesswork.

Current methods for studying microbiota, gut bacteria for example, take a sample from an area of the body and then look at the genetic material thats present. This process inherently lacks important context, according to the authors.

Its impossible to really understand what microbe communities are doing if we dont first understand the extent of the community and how frequently and where else they might be occurring in the body, said Steve Woloszynek, PhD, and MD trainee in Drexels College of Medicine and co-author of the paper. In other words, its hard to develop treatments to promote natural microbial coexistence if their natural state is not yet known.

Obtaining a full map of microbial communities, using themetagenomics, allows researchers to observe how they change over time both in healthy people and those suffering from diseases. And observing the difference between the two provides clues to the function of the community, as well as illuminating the configuration of microbe species that enables it.

Most metagenomics methods just tell you which microbes are abundant therefore likely important but they dont really tell you much about how each species is supporting other community members, Rosen said. With our method you get a picture of the configuration of the community for example, it may have E. coli and B. fragilis as the most abundant microbes and in pretty equal numbers which may indicate that theyre cross-feeding. Another community may have B. fragilis as the most abundant microbe, with many other microbes in equal, but lower, numbers which could indicate that they are feeding off whatever B. fragilis is making, without any cooperation.

One of the ultimate goals of analyzing human microbiota is to use the presence of certain microbe communities as indicators to identify diseases like Crohns or even specific types of cancer. To test their new method, the Drexel researchers put it up against similar topic modeling procedures that diagnose Crohns and mouth cancer by measuring the relative abundance of certain genetic sequences.

The themetagenomics method proved to be just as accurate predicting the diseases, but it does it much faster than the other topic modeling methods minutes versus days and it also teases out how each microbe species in the indicator community may contribute to the severity of the disease. With this level of granularity, researchers will be able to home in on particular genetic groupings when developing targeted treatments.

The group has made its themetagenomics analysis tools publicly available in hopes of speeding progress toward cures and treatments for these maladies.

It's very early right now, but the more that we understand about how the microbiome functions even just knowing that groups may be acting together then we can look into the metabolic pathways of these groups and intervene or control them, thus paving the way for drug development and therapy research, Rosen said.

This research was supported by the National Science Foundation.

In addition to Rosen and Woloszynek, and Zhengqiao Zhao, PhD, from the Department of Electrical and Computer Engineering; Joshua Mell, MD, from Drexels College of Medicine; and Gideon Simpson, PhD, and Michael OConnor, PhD, from Drexels College of Arts & Sciences, participated in the research.

Read the full paper here:http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219235

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Teams of Microbes Are at Work in Our Bodies. Researchers Have Figured Out What Theyre up… – ScienceBlog.com

Posted: at 2:51 pm

An algorithm akin to the annoyingly helpful one that attempts to auto-complete text messages and emails is now being harnessed for a better cause. A group of Drexel University researchers are using its pattern-recognition ability to identify microbial communities in the body by sifting through volumes of genetic code. Their method could speed the development of medical treatments for microbiota-linked ailments like Crohns disease.

In the last decade, scientists have made tremendous progress in understanding that groups of bacteria and viruses that naturally coexist throughout the human body play an important role in some vital functions like digestion, metabolism and even fighting off diseases. But understanding just how they do it remains a question.

Researchers from Drexel are hoping to help answer that question through a clever combination of high-throughput genetic sequencing and natural language processing computer algorithms. Their research, which was recently published in the journal PLOS ONE, reports a new method of analyzing the codes found in RNA that can delineate human microbial communities and reveal how they operate.

Much of the research on the human microbial environment or microbiome has focused on identifying all of the different microbe species. And the nascent development of treatments for microbiota-linked maladies operates under the idea that imbalances or deviations in the microbiome are the source of health problems, such as indigestion or Crohns disease.

But to properly correct these imbalances its important for scientists to have a broader understanding of microbial communities as they exist both in the afflicted areas and throughout the entire body.

We are really just beginning to scrape the surface of understanding the health effects of microbiota, said Gail Rosen, PhD, an associate professor in Drexels College of Engineering, who was an author of the paper. In many ways scientists have jumped into this work without having a full picture of what these microbial communities look like, how prevalent they are and how their internal configuration affects their immediate environment within the human body.

Rosen heads Drexels Center for Biological Discovery from Big Data, a group of researchers that has been applying algorithms and machine learning to help decipher massive amounts of genetic sequencing information that has become available in the last handful of years. Their work and similar efforts around the world have moved microbiology and genetics research from the wet lab to the data center creating a computational approach to studying organism interactions and evolution, called metagenomics.

In this type of research, a scan of a genetic material sample DNA or RNA can be interpreted to reveal the organisms that are likely present. The method presented by Rosens group takes that one step farther by analyzing the genetic code to spot recurring patterns, an indication that certain groups of organisms microbes in this case are found together so frequently that its not a coincidence.

We call this method themetagenomics, because we are looking for recurring themes in microbiomes that are indicators of co-occurring groups of microbes, Rosen said. There are thousands of species of microbes living in the body, so if you think about all the permutations of groupings that could exist you can imagine what a daunting task it is to determine which of them are living in community with each other. Our method puts a pattern-spotting algorithm to work on the task, which saves a tremendous amount of time and eliminates some guesswork.

Current methods for studying microbiota, gut bacteria for example, take a sample from an area of the body and then look at the genetic material thats present. This process inherently lacks important context, according to the authors.

Its impossible to really understand what microbe communities are doing if we dont first understand the extent of the community and how frequently and where else they might be occurring in the body, said Steve Woloszynek, PhD, and MD trainee in Drexels College of Medicine and co-author of the paper. In other words, its hard to develop treatments to promote natural microbial coexistence if their natural state is not yet known.

Obtaining a full map of microbial communities, using themetagenomics, allows researchers to observe how they change over time both in healthy people and those suffering from diseases. And observing the difference between the two provides clues to the function of the community, as well as illuminating the configuration of microbe species that enables it.

Most metagenomics methods just tell you which microbes are abundant therefore likely important but they dont really tell you much about how each species is supporting other community members, Rosen said. With our method you get a picture of the configuration of the community for example, it may have E. coli and B. fragilis as the most abundant microbes and in pretty equal numbers which may indicate that theyre cross-feeding. Another community may have B. fragilis as the most abundant microbe, with many other microbes in equal, but lower, numbers which could indicate that they are feeding off whatever B. fragilis is making, without any cooperation.

One of the ultimate goals of analyzing human microbiota is to use the presence of certain microbe communities as indicators to identify diseases like Crohns or even specific types of cancer. To test their new method, the Drexel researchers put it up against similar topic modeling procedures that diagnose Crohns and mouth cancer by measuring the relative abundance of certain genetic sequences.

The themetagenomics method proved to be just as accurate predicting the diseases, but it does it much faster than the other topic modeling methods minutes versus days and it also teases out how each microbe species in the indicator community may contribute to the severity of the disease. With this level of granularity, researchers will be able to home in on particular genetic groupings when developing targeted treatments.

The group has made its themetagenomics analysis tools publicly available in hopes of speeding progress toward cures and treatments for these maladies.

Its very early right now, but the more that we understand about how the microbiome functions even just knowing that groups may be acting together then we can look into the metabolic pathways of these groups and intervene or control them, thus paving the way for drug development and therapy research, Rosen said.

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Teams of Microbes Are at Work in Our Bodies. Researchers Have Figured Out What Theyre up... - ScienceBlog.com

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Work is part of being human – robots won’t stop us doing it – TechCentral

Posted: at 2:51 pm

Hardly a week goes by without a report announcing the end of work as we know it.

In 2013, Oxford University academics Carl Frey and Michael Osborne were the first to capture this anxiety in a paper titled: The Future of Employment: How susceptible are jobs to computerisation?.

They concluded 47% of US jobs were threatened by automation. Since then, Frey has taken multiple opportunities to repeat his predictions of major labour market disruptions due to automation.

In the face of threats to employment, some progressive thinkers advocate jettisoning our work ethic and building a world without work.

If machines can do our work, why not reduce the working week drastically? We should be mature enough to decide what truly matters to us, without tying our identity to a job, or measuring happiness in dollars and professional status. Right?

Not quite.

The reality is that work is tied to our constitution as a species. And this fact is too often overlooked in discussions about the future of work.

Recent studies have raised alarms that advances in automation and artificial intelligence (AI) will leave all sectors open to the threat of machines replacing human workers.

The power of AI will supposedly, according to these studies, even make high-skilled specialists redundant threatening medical practitioners, bank associates and legal professionals.

Predictions about the rise of the robots either take a pessimistic stance, focusing on disruptions to economic organisations, or view undoing work as an opportunity to move to a fairer social model.

However, these views disregard the central role work has played in humanitys development.

Philosophers including Karl Marx, Henri Bergson and John Dewey argued that working is a defining trait of humans.

Findings over the past two decades have confirmed that features of modern Homo sapiens are directly tied to their tendency to work.

Three basic ideas of the old philosophers are reaffirmed by contemporary research in archaeology, anthropology and genetics.

First, humans havent evolved to fit into their environments as seamlessly as other animals. Humans have had to compensate for a lack of fit.

They did this by learning about the ecosystems around them, the plants and animals they could eat, and the natural processes they could use, or should avoid. This knowledge was applied to create instruments, tools and weapons.

Very early on, humans mobilised their knowledge and skills to shape their immediate surroundings and become the dominant animal.

Knowledge of nature, technical skills and intervention in the environment are all characteristics of humans capacity to work. These allowed us to adapt to highly diverse geographies and climates.

Each new generation has to learn the skills and knowledge that will enable it to sustain its particular mode of survival.

Australian philosopher Kim Sterelny has shown in detail how evolution selected genetic traits that sustain humans capacity to learn, specifically by enhancing social behaviour and tolerance towards the young.And as humans worked on nature, they also worked in ways that influenced their minds, and their bodies.

It has been demonstrated that cooperation in humans reaches a level unknown in other species. This cooperative capacity has its roots in each individuals dependency on the knowledge, skills and efforts of others.

No human is able to sustain himself on his own, and collaboration exceeds what each person can produce alone. Even the most brilliant astrophysicist calls the plumber to fix a broken toilet.

Humans have to work to survive, and this entails working with, and for, others.

Acknowledging the anthropological depth of work means admitting current scenarios advocating the end of work are not the right answer. They take an unrealistic view of who we are.

We need to recognise work as a human need. As Marx said: Labour has become not only a means of life, but lifes prime want.

The question should not be whether theres room for human work in an automated future. The question should be: how will human work find its place next to machines and robots?

Even if automation becomes widespread, well still apply our minds, bodies and hands to productive tasks. Well still experiment and learn from others.

If machines could truly do all human work, then theyd make humans redundant, as 2001: A Space Odyssey anticipated back in 1968. While this isnt a pleasant scenario, its not a likely one either.

Automation might bring major social and economic disruptions in the short term, but it wont get rid of the need for humans to work.

Human needs are also infinitely complex. Nobody can foretell what new activities, techniques and consequent modes of working will fulfil future needs.

Even if we reject the modern work ethic, well still find ways to learn through action and emulate experts.Human intelligence is geared toward producing useful goods, so well continue to look for purposeful activities, too. And well seek collaboration with others for mutual benefit.

This is the influence of work on us. We are heir to thousands of years of evolution, and it would be pretentious to assume evolution could stop with us.

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Work is part of being human - robots won't stop us doing it - TechCentral

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