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Friday view of the space station – kwwl.com
Posted: December 13, 2019 at 3:21 pm
Friday was a beautiful evening to check out the International Space Station (ISS). It was scheduled to appear in the NW sky at 5:37 pm and disappear in the ENE at 5:41 PM.
Mark Brown, from Marion, was set up to take some amazing space related photos. He uses an 11-inch scope with a Canon 6D DSLR attached to the telescope.
He shared the photos you are about to see of the moon and the ISS crossing in front of it.
Before we get to the photos did you know the space station is about the size of a football field?
The ISS orbits the Earth 16 times a day as it travels about 17,500 mph. This means it travels around the world in 90 minutes. It stays at an altitude of 248 miles above the Earth.
Now lets look at the photos from December 6th. The first one shows a beautiful shot of the moon. On the right half of the moon there is a dark spot...that is the ISS
If you didn't see it on the above photo, the photo below I outlined the area and zoomed in so you can see the ISS.
Now the last photo is a composite image showing the path of the ISS took across the moon.
A special thanks to Mark Brown for sharing his photos for this post.
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Friday view of the space station - kwwl.com
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Photo of the day: Brightly-lit Bucharest photographed at night from the International Space Station – Romania-Insider.com
Posted: at 3:21 pm
Photo of the day: Brightly-lit Bucharest photographed at night from the International Space Station
The US space agency NASA has published a photo of Romania's capital Bucharest taken at night from the International Space Station. The photo shows the brightly-lit city with its boulevards and surroundings.
"The brightly lit capital city of Romania, Bucharest with a population of almost 1.9 million, is pictured from the International Space Station as it orbited 263 miles above the eastern European nation," reads NASA's caption to the photo.
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Photo of the day: Brightly-lit Bucharest photographed at night from the International Space Station - Romania-Insider.com
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Space mice and robotic avatars headed for the International Space Station – The Star Online
Posted: at 3:21 pm
Space mice, radiation vests, robotic avatars and recycling polymers for 3D printers were among the science experiments bound for the International Space Station (ISS) on the latest commercial resupply mission from Virginia, the United States.
Northrop Grummans 12th robotic mission and its first under a new Nasa contract launched on Nov 2, from the state-owned Mid-Atlantic Regional Spaceport on Wallops Island.
Antares rocket launches were visible from Hampton Roads and throughout the mid-Atlantic.
This latest cargo run of an uncrewed Cygnus spacecraft had Nasa scientists turning nostalgic.
Were a little over a year away from a big milestone for us: 20 years of continuous human presence aboard the International Space Station, said Bryan Dansberry, assistant programme scientist for the ISS.
Over 19 years ago, the station started out as an orbiting outpost that has really evolved into a robust and surprisingly versatile laboratory.
To date, Dansberry said, more than 2,900 investigations have been conducted by nearly 4,000 investigators representing 108 countries. In September, astronauts set a record: one week of 127 hours of astronaut time devoted to research, besting the record set in May.
And this year, said Michael Roberts, interim chief scientist for the ISS US National Laboratory, is the most prolific year of research on the space station by a wide margin.
When the Cygnus spacecraft arrived, station crew unloaded groceries, hardware and about 2,090kg of science payload (the carrying capacity of a launch vehicle). Theyd have found the latest in a Budweiser investigation into how germinated barley seeds can be processed in a microgravity environment, and an alliance of Italian auto-maker Lamborghini and Houston Methodist Research Institute to test the strength of 3D-printed carbon fibres in space.
Other experiments included: Rodent Research-14, the first time a life sciences mission using rodents launched on a Cygnus. The goal was to document the effect of microgravity on the biological circadian rhythm, specifically the 12-hour circatidal clock thats believed to control stress levels and protein responses and co-ordinate metabolism.
Part of the goal there is to understand how persons in space respond to these stresses in the absence of gravity, said principal investigator Brian York of the Baylor College of Medicine in Houston. Understanding these mechanisms will hopefully identify pathways that can be pharmacologically targeted in order to manipulate them on station or during travel for long space flight.
Here on Earth, the study could lead to new therapies for metabolic diseases that contribute to insulin resistance, type 2 diabetes and cancer.
According to Nasa, the mice will eventually be sacrificed by the station crew, dissected and their blood and tissue frozen for return to Earth.
In a joint effort by Nasa and the Israel Space Agency, the AstroRad vest is being developed to shield astronauts from the threat of deep space radiation. On this mission, a prototype would be used to gather ergonomic feedback from astronauts on its fit, form and function.
This particular vest is tailored for a female crew member, said Kathleen Coderre, principal investigator with Lockheed Martin in Denver, which built the vest of high-density polyethylene, a thermoplastic polymer. Vests for females will be thicker around sensitive organs, she said, which will make it slightly bulkier.
Also, females do have a greater sensitivity to the space radiation environment. So it is a goal to make a comfortable vest to protect both male and female, but the female use case, from an ergonomics perspective, actually will give us a little bit better data, Coderre said.
The human/robot interface will get a test run in a European Space Agency initiative to see how well an orbiting astronaut can control a robot on the surface of the moon or another planet.
Simply spoken, we want to pick up a rock. So the astronaut will have a robotic avatar on the surface of the moon and can command the robot with an advanced user interface, said Thomas Krueger, team lead of ESAs Human-Robot Interaction Lab.
In this case, though, the rock will be on some Earth terrain filling in for the lunar surface. The experiment is considered an analog scenario for future lunar or Martian exploration, Nasa said.
The Made In Space Recycler that headed for the space station was built to break down used polymer parts and materials into feedstock filament. Astronauts can then use that filament to print out new items using the Made In Space 3D printer already operating on the station.
Were trying to improve the sustainability of manufacturing capabilities on the station, so that way we dont have to continue to launch polymer in the form of filament, said Michael Snyder, principal investigator at Made in Space Inc in Jacksonville, Florida. This is significant because of the implication for future exploration missions, as well as the commercialisation of low-Earth orbit.
Recycled filament as well as items made from it will be returned to Earth for testing. Snyder said in-space manufacturing is essential for future exploration missions to the moon or Mars, while the technology also has applications for recycling and conserving resources here on Earth. Tribune News Service / Daily Press (Newport News, VA) / Tamara Dietrich
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Space mice and robotic avatars headed for the International Space Station - The Star Online
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Experiment from Ballenas students heads to International Space Station – Nanaimo News Bulletin
Posted: at 3:21 pm
From left: Ballenas Secondary students Spencer Bradbury, Victor Kamel and Yehia El Karsh. (Carl Savage photo)
Entries from 23 countries; Ballenas is one of 11 schools chosen in Canada
Three students from Ballenas Secondary School will have an experiment they designed sent to the International Space Station.
Victor Kamel, Yehia El Karsh and Spencer Bradburys experiment is part of an educational initiative by the European Space Agency and the Raspberry Pi Foundation to get young people engaged and excited about space.
The students hope is that their computer code will be able to detect small changes to the ISSs orbit as it moves through the thin upper atmosphere of the earth. To do this, they will use sensors that are already on board the ISS. Once their data has been collected, it will be sent back for analysis.
READ MORE: It was kind of surreal: Parksville students grow sprouts in space
The three students plan to attend post-secondary programs in science or engineering in the fall.
Conducting research on the ISS is a dream of many scientists. It is incredible to think that we have this opportunity as high school students, said Spencer in a press release.
NEWS Staff
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Experiment from Ballenas students heads to International Space Station - Nanaimo News Bulletin
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U.K. Election: Brexit Wins, Jeremy Corbyn Crashes – Reason
Posted: at 3:04 pm
The U.K. election has delivered a huge victory to conservativesand to Tory leader Boris Johnsonand astounding losses to the Labour Party. The results mean much more than the Conservative Party continuing to control the U.K.'s governing bodies.
With at least 364 seats won, the Conservative Party has well surpassed the number required for a majority in Parliament. Prime Minster Boris Johnson "will now enjoy a comfortable majority to 'get Brexit done'in other words, to pass the withdrawal agreement that he negotiated with European Union leaders in October," notes The Economist.
"In truth, the election-night story was not so much that of a Tory surge but of a Labour slump," the magazine adds.
The Jeremy Corbynled Labour Party will see its parliamentary vote share drop eight points. It was the party's worst showing since 1935.
Labour's steepest drops came in areas where the Nigel Farageled Brexit Party did well. (But asThe Spectator notes, Farage's party did not "even come close to winning a single parliamentary seat.")
In any event, it looks like Brexit is on.
And with the chances of Scottish secession rising again, some say this could kick off the destruction of the United Kingdom itself.
The election also speaks to the rising power of combining left-leaning economic policy with conservative social views and immigration policies (so, you know, the worst of all words for free minds/markets/migration types).
Britain's third largest party, the Liberal Democrats, also "had a dreadful night," points outThe Economist. And yet
the Tories' mighty new coalition is sure to come under strain. With its mix of blue collars and red trousers, the new party is ideologically incoherent. The northern votes are merely on loan. To keep them Mr Johnson will have to give people what they wantwhich means infrastructure, spending on health and welfare, and a tight immigration policy. By contrast, the Tories' old supporters in the south believe that leaving the EU will unshackle Britain and usher in an era of freewheeling globalism. Mr Johnson will doubtless try to paper over the differences. However, whereas Mr Trump's new coalition in America has been helped along by a roaring economy, post-Brexit Britain is likely to stall.
Some say the results highlight how it's easier for right-leaning politicians and parties to embrace left-leaning policies than vice versa, though this idea has its skeptics:
"The British election results, like any election result, is the result of unique circumstances and multiple factors," suggests Jonathan Chait at Intelligencer. "It is also, however, a test of a widely articulated political theory that has important implications for American politics. That theory holds that Corbyn's populist left-wing platform is both necessary and sufficient in order to defeat the rising nationalist right. Corbyn's crushing defeat is a decisive refutation."
"Vaping policy" consumes White House.
A good piece from Jane Coaston on the new porn wars, with cameos by Katherine Mangu-Ward and myself:
For several decades now, movement conservatism has adhered to Andrew Breitbart's maxim that "politics is downstream of culture," arguing that rather than engage the forces of government to create change, conservatives should focus on changing popular culture instead. But some social conservatives are now arguing the very opposite.
Arguments in favor of the use of laws to change or improve human behavior hasn't been a characteristic of the post-2010 conservative movement that still bears the influence of the Tea Party and libertarian-leaning Republicans. In fact, Mangu-Ward told me that such arguments were, in her view, generally made by left-leaning politicians and thinkers. Referencing former New York City Mayor Michael Bloomberg's efforts to ban large sodas, she said such rationales stem from "the idea that we should prohibit people from making bad choices," or in short, "make the bad thing illegal."
Catholic theocrat and New York Post op-ed editor Sohrab Ahmari told Coaston that pornography is "degrading" and "Andrea Dworkin was right."
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U.K. Election: Brexit Wins, Jeremy Corbyn Crashes - Reason
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A Federal Government Thats Not Good at Its Job Cant Effectively Serve the Common Good – National Review
Posted: at 3:04 pm
A view of the U.S. Capitol, in Washington DC, U.S., June 20, 2019. (Al Drago/Reuters)Well-intentioned though conservatives calling for a more activist government may be, ours has failed miserably with the responsibilities it already has.
The 2007 comedy Hot Fuzz is about a hyper-competitive London policeman who is reassigned to what initially appears to be the sleepiest, most boring small town in the entire United Kingdom. After a series of wildly suspicious deaths that the other cops insist must be accidents, the policeman and his partner uncover SPOILER ALERT a cabal of locals who are murdering their neighbors over the most minor flaws and sins, all insisting, in a ludicrous chant, that their actions serve, the greater good. The bad actor in the local theater, a local woman with an annoying laugh, a resident with an ostentatious house the town elders murder each one, all in the name of preserving the communitys award-winning reputation.
Fairly or not, every time I hear someone calling for common-good capitalism even someone as likable and usually reliable as Senator Marco Rubio I hear those deranged villagers who insist that enforcing their draconian punishments is for the greater good.
The common good can be pretty subjective. While its not that difficult to get Americans to agree on what is good in the broadest terms, its a lot tougher to build a consensus view of the good when you get down to specifics not to even mention the difficulty of forging a consensus view of how to bring the good about. Rubio, who is after all a politician, lists dignified work, strong families, and strong communities in his definition. You would have to look far and wide to find an American who wants to see more undignified work, weak families, and weak communities. But while most might agree with Rubios goals, whether and how federal policy can achieve them are open questions.
For example, Rubio warns, Weve allowed ourselves to become almost completely dependent on China for rare-earth minerals and wants the secretary of commerce to establish a privately funded, privately operated and privately managed Rare Earth Refinery Cooperative. Thats nice. Its probably a good idea, though some may wonder why, if everything about this is going to be private, we need the Department of Commerce to set it up. But its hard to believe that even if it were a success, it would do much more than nibble at the edges of whatever ails us.
The biggest obstacle to getting access to the 18 million tons of rare-earthminerals in Bear Lodge, Wyo. is securing permits and overcoming objections from environmentalists. It is odd that a proposal like Rubios is treated as part of a new force in opposition to libertarianism, but it runs into the same complaints about government bureaucracy, slow permitting, and red tape made chiefly by . . . libertarians.
Rubios other ideas are the sort that shouldnt really raze libertarian hackles that much: expanding the federal per-child tax credit, reforming the Small Business Administration, and so on. But they feel like small potatoes. If our capitalist system is doing a lousy job of serving the common good, well, that probably at least partially reflects problems in how our government regulates and creates incentives within it. Many Republicans and almost all Democrats are dancing around the glaring contradiction of asking a government thats doing a terrible job fulfilling its current responsibilities to do more.
To listen to the Democratic presidential candidates, U.S. Immigration and Customs Enforcement officials are a bunch of xenophobic thugs, Customs and Border Patrol officers are abusing innocent children, the Office of Management and Budget held up aid to Ukraine for corrupt reasons, the entire federal government is asleep at the wheel when it comes to protecting our elections and voting systems, the Department of Justice keeps giving grants to police forces full of cops who are racist and abusive . . . and the only solution is to give the government more money and power.
Do these folks realize that their primary tool for promoting the common good is the sputtering, jury-rigged, frequently malfunctioning Rube Goldberg machine known as the federal government?
With almost comical regularity, if you ask the federal government to do X, it will, given tons of funding and having the best of intentions, accidentally give you the opposite of X. We have a Bureau of Alcohol, Tobacco, Firearms and Explosives that sent 2,000 guns to Mexican cartels. We have an Environmental Protection Agency that accidentally released 3 million gallons of wastewater tainted with iron, aluminum, manganese, lead, copper, and other metals into rivers in three states. The Office of Personnel Managements job is to collect and protect information about federal employees; it did a terrific job of putting all of the potential blackmail material on every government employee who handles classified information in one place for Chinese hackers to steal. We have a Transportation Security Administration that failed to find hidden fake explosives in 67 out of 70 tests. The Special Inspector General for Afghan Reconstruction found that the Pentagon could only account for 38 percent of the $3.8 billion allocated for the Commanders Emergency Response Program. The Department of Education spent more than $45 million on537 charter schools that never opened. If you put the federal government in charge of banning porn, youd probably end up getting Stormy Daniels videos sent to your phone by FEMA.
Is it really a good idea to give these folks bigger, more complicated duties?
A lot of good people work for the federal government. Unfortunately, its hard to get rid of the bad people who work there, and the good ones toil away in systems and offices that discourage change and new ideas, have few if any incentives for efficiency, use outdated technology, drown in paperwork, and have an obsessive fear of lawsuits. In addition to the traditional problems, in recent years many federal agencies have coped with a revolving door in their leadership. In his first 31 months in office, President Trump had two defense secretaries, two acting defense secretaries, two secretaries of homeland security, two acting secretaries of homeland security, two secretaries of state, one acting secretary of state, two CIA directors, and three chiefs of staff.
All of these existing agencies have a well-established mission meant to serve the greater good, from dont let weapons get onto planes to help build a decent society in Afghanistan to open new charter schools. Some days they succeed, but all too often they fall flat on their faces. That fact should give pause to Senator Rubio and others on the right pushing for expanded government powers in the service of conservative ends.
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WALSH: Every Child Exposed To Internet Pornography Is An Abuse Victim. There Should Be Laws Protecting Them. – The Daily Wire
Posted: at 3:04 pm
Im fascinated by the debate that has been raging these past several days among conservatives around the issue of pornography. Im happy to accept blame for helping to start this scuffle because I think it has been a clarifying moment for conservatism. As Jane Coaston outlined in her fair and insightfulreporting at Vox,the dispute over porn regulation really springs from a more fundamental disagreement about the actual purpose of government.
Guys like Sohrab Ahmari have come down on the pro-regulation side, while the libertarians at Reason have settled, unsurprisingly, on the other. The dividing line even runs through The Daily Wire. My colleaguesMichael Knowles and Josh Hammerjoin Ahmari, myself, and others in the view that government has a legitimate role in battling the porn epidemic, while Ben Shapiroand Jeremy Boreingsay that it should not have a substantial role and any role, if there is one, should not include an outright ban. I think everyone cited above has contributed thoughtfully to the discussion, and Im not just saying that because two of them happen to sign my paychecks.
But through this whole back-and-forth, I havent seen anyone engage with what I consider to be my strongest argument. Putting aside, for a moment, the philosophical discussion about the nature of government and the states role in preserving the common good an important conversation, but one that leads us far into the weeds and loses sight of the original subject in the process Id like to re-emphasize a very simple point Ive made about the porn problem, specifically.
The defense of pornography, or at least of its remaining legal and mostly unregulated, seems to hinge on the fact that the content is produced and viewed by consenting adults. If viewers do not consent to viewing a sexual act, we all presumably agree that a crime has occurred. It would seem to strain the bounds of the most radical libertarianism to argue that a group of adults are within their rights to have an orgy on the subway, for example.
Porn is different, its argued, because you only view it if you seek it out. If viewers of porn were not consenting if internet porn were of such a nature that millions of people were forced to encounter it against their will every year then it would seem that the argument against prohibition or regulation begins to crumble. Well, I think it has already crumbled because indeed millions of people are exposed to itevery year against their will and consent. Those defending the legality of porn seem to be ignoring this group of victims, and I think that is an insurmountable moral and logical flaw in their position.
Children are first exposed to porn at the age of 11, on average. As we speak right now, there are no doubt millions of minors, some as young as five or six years old, watching adults have sex on the internet. This is an indisputable fact. Does the fact not blow to smithereens the consent excuse offered by the other side? Our legal system rests on the assumption that minors cannot consent to engage in sexual acts. If an adult has sex with a child, the adult is guilty of rape no matter if the child verbally agreed or not. In our society, we understand that children lack the mental and emotional maturity to make an informed decision in this area. To deny that is to literally defend pedophilia.
Well, if children cannot consent to engage in a sexual act, does it not inevitably follow that they cannot consent to witness such an act? If they cannot consent as a second-party participant, neither can they consent as a third-party participant. Thus, every child who watches porn does so, by definition, without consent. Again: I dont see how you can quibble with this argument without also quibbling with the logic for criminalizing pedophilic behavior. Im not saying that the people on the opposite side of this issue are trying to legalize pedophilia. Im saying that they fail to appreciate how our laws against pedophilia also provide a basis for pornography regulation.
This all means that every consenting adult who posts hardcore sex videos to the internet does so knowing that children can very easily access and view it. They are putting it, as it were, within reach of the child. If the child reaches for it, who do we blame? Is it the childs fault or the fault of the person who put it there? I would argue that every child who has viewed internet pornography is a victim of abuse. And the abuser is the person who posted that content where a child, with no trouble at all, could find it.
Indeed, the internet porn industry makes hundreds of millions of dollars every year on children. Each hit to a site like Pornhub is monetized. If millions of children go on that site which they do, because theres nothing to stop them then Pornhub profits to the tune of millions on the psychological and sexual abuse of children. If you dont think the government has an interest in the common good, broadly speaking, will you admit that it at least has an interest in preventing people from making millions on providing pornography to 12-year-olds?
The obvious dodge here is to lay the onus entirely at the feet of parents. Its not the pornographers fault, critics will respond. Its up to the parent to stop their kids from seeing this stuff. I find this rejoinder to be profoundly lazy. Its true that parents should be doing all they can to shield their children from the filth on the internet, but its also true that the internet is so ubiquitous that parents cannot, on their own, do a sufficient job in this regard. Even if the child has no phone and no internet access at home or, more likely, regulated internet access at home he can still go almost anywhere else and access the internet dozens of different ways. Short of moving into a cave in the desert, a parent can only provide partial cover. But partial cover, in the end, is only a little better than no cover at all.
Besides, this does nothing to relieve the responsibility of the person posting the content in the first place. Even if every child exposed to porn has ineffectual and inattentive parents (which is most emphatically not the case), that still doesnt explain why anyone should have the right to post sex videos on a public forum where children can easily access them. It might be true that some children who are molested could have been saved that trauma had their parents been more vigilant, but that does absolutely nothing at all to excuse the man who did the molesting. The same holds true for pornographers.
The question is this: Do we have a natural human right to post hardcore sex videos online where children can see them? Anyone who says yes has an extremely confused and hopelessly ambiguous conception of human rights. The rational people who say no, however, must weigh whether a persons privilege to post such content outweighs the right of a child to be free from sexual abuse and trauma.
This does not have to be a deeply philosophical debate about philosophies of governance and so on. This can be much simpler. You do not have a right to expose children to sexually explicit content. Children do have a right to certain basic legal protections. That fact alone, in my view, is enough to settle the argument.
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GenEdit and Editas Medicine Enter into Exclusive License and Collaboration Agreement for Nanoparticle Gene Therapy Delivery – Business Wire
Posted: at 3:02 pm
BERKELEY, Calif.--(BUSINESS WIRE)--GenEdit, Inc., a developer of a novel polymer nanoparticle technology platform for non-viral- and non-lipid-based delivery of gene therapies, today announced that it has entered into a worldwide, exclusive license and collaboration agreement with Editas Medicine, Inc., a leading genome editing company. GenEdit has developed a comprehensive delivery system for CRISPR-based therapeutics, including gene knockout and gene repair therapies, to enable safer delivery options with improved efficiency.
"This license and collaboration agreement further validates the strength of our intellectual property portfolio and the potential of GenEdits technology," said Kunwoo Lee, Ph.D., co-founder and chief executive officer of GenEdit. "We are pleased to establish our relationship with Editas Medicine as they leverage our technology to develop potential genomic medicines."
Under the terms of the agreement, GenEdit has granted Editas Medicine an exclusive worldwide license, with rights to sublicense, to GenEdits Cpf1-based technologies. In return for these rights, GenEdit will receive undisclosed upfront and development milestone payments, including royalties on net sales of products incorporating the licensed intellectual property. In addition, GenEdit and Editas Medicine will collaborate on evaluating delivery of Cpf1-based technologies with GenEdits nanoparticle platform. Editas Medicine will provide research funding and have an option to continue development after the initial collaboration period.
GenEdits nanoparticle platform consists of a proprietary non-viral, non-lipid library of polymers that efficiently encapsulate and deliver cargo [RNA, DNA, protein and/or ribonucleic acid-protein complexes (RNP)] to specific tissues. The company screens the library to identify initial hits and then uses computational analysis and medicinal chemistry for iterative lead optimization. The company has used this platform to identify multiple candidate polymers for efficient and specific delivery of gene editing to a range of tissues.
"Compared to viral vectors and lipid-based nanoparticles, our approach has the potential for better targeting, more cargo, and lower manufacturing cost," said Timothy Fong, Ph.D., chief scientific officer of GenEdit. "In particular, our approach has the potential to enable in vivo gene editing of multiple tissues with CRISPR and expand the potential of gene therapies to treat more diverse sets of diseases."
About GenEdit
GenEdit was founded to transform the delivery of gene and gene editing therapies. We have synthesized the NanoGalaxy library of polymers that can encapsulate RNA, DNA, protein and/or RNP. Through advanced screening methods, computational analysis and iterative medicinal chemistry, we have demonstrated efficient delivery of gene editing cargo to specific tissues. We seek development partnerships for specific tissues and/or gene targets while advancing our internal pipeline of gene editing therapies.
For more information, please visit http://www.genedit.com.
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GenEdit and Editas Medicine Enter into Exclusive License and Collaboration Agreement for Nanoparticle Gene Therapy Delivery - Business Wire
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Personalized CF Medicine to be Tested for Rare Genetic Defects in Europe – Cystic Fibrosis News Today
Posted: at 3:02 pm
Three investigative therapies by Proteostasis Therapeutics PTI-801, PTI-808, and PTI-428 showed potential to treat cystic fibrosis (CF) patients ineligible for approved CFTR modulators after patient-specific lab models produced promising results that support a future clinical trial.
Funded by the EUs initiative HIT-CF (Human Individualized Therapy of CF), this early study was conducted on patient organoids, which are miniaturized organ models derived from patient cells.
Based on the positive results, a clinical trial in adult CF patients is expected to start in 2020. If successful, the trial results may serve as the basis for a marketing authorization applicationin Europe in 2021.
With the help of CF-Europe (a patient organization) and the European Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN), HIT-CF has been recruiting adult CF patients to collect tissue samples and create organoids, three-dimensional organ models grown in the lab.
Organoids mimic several characteristics of the organ from which they are derived, and are genetically identical to the donor. As such, they allow researchers to study biological processes and response to treatments in an environment that closely resembles human organs. As organoids are basically human cells cultured outside the body, they are said to be ex-vivo models.
The idea is to screen treatment candidates in the lab using intestinal organoids, or mini-intestines, obtained from rectal tissue (biopsies) of patients, which are collected through a quick and painless procedure. Then, based on how the organoids respond to each therapeutic candidate, a group of patients will be selected to enroll in a clinical trial.
Because the organoids can help determine the therapeutic candidate most likely to give the best results, researchers can personalize treatments for each patient before starting the trial.
So far, intestinal organoids from more than 300 patients have been created, of which 65 have been used to test Proteostasis potential CFTR modulators.
Proteostasis is honored to have been invited to participate in the HIT-CF project, and is the only company in the group with a combination of novel CFTR modulators being testedex-vivo. We are very enthusiastic about the progress of the study, Geoffrey Gilmartin, MD, chief medical officer of Proteostasis, said in a press release.
The positive results obtained on organoids support the launch of a clinical trial called CHOICES Crossover trial based on HumanOrganoidIndividual response inCF EfficacyStudy that will test the potential treatments on patients whose organoids responded favorably to the agents.
The study will also evaluate if organoids are good models to identify promising CF therapies, that is, if the responses measured on organoids translate to potential clinical benefits in patients, as reflected by lung function tests (FEV1) or sweat tests.
CHOICES will be a placebo-controlled, double-blind study that includes an eight-week treatment period, plus six months of constant dosing.
The study includes Proteostasis three candidate CFTR modulators, specially intended for patients who carry rarer CFTR genetic defects. All three compounds have different modes of action. PTI-801 works as a CFTR corrector, PTI-808 is a CFTR potentiator, and PTI-428 is a CFTR amplifier.
The trial is planned to start in mid-2020, with its first data anticipated for the end of 2020.
If moving forward, CHOICES will become the first trial based on personalized medicine for CF patients.
The inequality in access to CFTR modulators is an acute problem across Europe where 1 in 5 individuals do not have a F508del mutation [the most common CF-causing mutation]. In addition, drug reimbursement policies are leading to an ever-growing gap between patients who do, and those who do not have effective treatment options, said Christiane De Boeck, Work Package Leader at HIT-CF.
At HIT-CF Europe, we believe that novel strategies such as personalized medicine and development of new treatment options are central to addressing the inequality of access across the continent. We are thrilled with these initial results and look forward to providing additional updates, De Boeck added.
Gilmartin said that in Europe more than 2,300 adult CF patients are ineligible for approved CFTR modulators, and therefore excluded from participating in clinical trials.
This projects proposed personalized medicine approach is paving a potential new way to develop and provide access to novel CFTR modulators for patients with the most dire need for treatment options that target the cause of the disease. Additionally, based on an individual patients disease phenotype, and not just the genetic designation, this approach could also create a new path towards more effective treatment for all people with CF, Gilmartin said.
Proteostasis is also running a clinical trial evaluating a combination of the three candidate therapies for the treatment of CF patients who have at least one copy of the F508del mutation in the CFTR gene.
Ana is a molecular biologist enthusiastic about innovation and communication. In her role as a science writer she wishes to bring the advances in medical science and technology closer to the public, particularly to those most in need of them. Ana holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she focused her research on molecular biology, epigenetics and infectious diseases.
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Patrcia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
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Personalized CF Medicine to be Tested for Rare Genetic Defects in Europe - Cystic Fibrosis News Today
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Experts Forum: Creating a cluster of innovation in Rochester – Finance and Commerce
Posted: at 3:02 pm
Click on the image above to see the full magazine.
Innovation being synonymous with Mayo Clinic is nothing new. But now, thanks to Rochesters massive, multiyear undertaking to present the entire city as a beacon for innovators and entrepreneurs, the whole region 75 miles south of the Twin Cities is poised for a technological and economic renaissance.
Finance & Commerce recently hosted a panel discussion about what Rochesters future might hold in those regards. The chat took place at One Discovery Square in Rochester.
The panelists included:
Executive director, Collider Foundation
Traci Downs
President and CEO, Medical Alley Association
Shaye Mandle
Medical director of business development and dermatologic surgeon, Mayo Clinic
Dr. Clark Otley
President and CEO, Vyriad; professor, Mayo Clinic
Dr. Stephen Russell
Director of business development, Discovery Square
Chris Schad
Co-founder and general partner of Capita3
Pam York
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Experts Forum: Creating a cluster of innovation in Rochester - Finance and Commerce
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