Category Archives: Transhuman News

Rich Quelch, guest contributor, delves into the world of growing old, anti-ageing research and senotherapy.

Senotherapy is an emerging scientific field and based on recent estimates it could be widely available within the next decade. Approaching ageing from a cellular level, scientists the world over are investigating how to stop the process of senescence through medicinal means. But were still a long way off commercialisation and there are unanswered questions around what this means for the human race.

Life expectancy is rising in most of the developed world, with people in England and Wales now living almost 25 years longer than they did a century ago. The ONS predicts the UKs population of over-65-year-olds will increase by 8.6 million in the next 50 years.

How to help people age healthily and lessen the growing burden of old age on global healthcare systems and economies is one of the most pressing questions currently faced by civilisation.

The leading causes of death worldwide are age-related illnesses like cardiovascular diseases, cancer, and neurodegenerative diseases. If this trend can be reversed and people can live healthier for longer without the need for clinical care, the impact would be huge.

Technology has an especially important role to play here. So much so, Agetech is being met with the same level of excitement as fintech in the mid-2010s, with many Silicon Valley giants like Facebook and Alphabet investing billions. As an industry, its already estimated to be worth 179.91bn* globally.

The opportunities for pharma in tackling mortality and increasing the human lifespan are also not to be understated. However, the complex cellular and molecular processes that underlie age-related diseases have continued to elude us in their pathology. However, the tide seems to be turning and scientists may have just unlocked the key to slowing ageing.

Enter senolytics, the next big thing in anti-ageing research. Cellular senescence, leading to tissue dysfunction, is widely accepted as contributing to ageing and the development of debilitating age-related diseases. This is because, as we get older, an increasing number of the bodys cells enter a state known as senescence which results in the loss of a cells power to divide and grow.

Surrounding cells then start to become affected and as more and more enter this state, the bodys ability to repair tissue, control inflammation and protect against the risk of age-related diseases is compromised. The more senescent cells a person accumulates, it seems the faster their biological clock ticks.

Increasingly, the scientific community is exploring whether the process of senescence can be therapeutically targeted to help to slow or even halt it. As the median age for cancer, Alzheimers, Parkinsons and other age-related diseases are high (60+), understanding their pathology can reveal new insights into what mechanisms also cause ageing.

For example, neurodegenerative diseases (NDDs) share cellular and molecular mechanisms commonly seen in ageing cells such as inflammation, mitochondrial dysfunction and oxidation stress.

We recently had a first glimpse of what might be possible in senotherapy. In the first in-human trial of senolytics, the results were promising; these drugs were successful in removing senescent cells in the same way in people as in mice. Specifically, the administration of senolytics improved the physical function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associated disease where the lungs become scarred and breathing becomes increasingly difficult.

By 2100, its estimated 25% of the worlds population will be aged 60 or above, so the potential of senolytics to transform geriatric medicine and help people to age healthily is immense.

But, its important to understand the multidimensional challenges senotherapy may present the pharma industry, healthcare systems, governments and individuals if, or indeed when, we reach the stage of commercialisation.

The longevity industry is highly complex; a space where many industries overlap and intersect, requiring synergy and collaboration between pharma, technology, finance, health and social care, government departments, bodies and agencies, and political parties.

In this diverse and dynamic field, creating concrete understanding amongst all partners and making accurate forecasts will be hugely challenging particularly given the rapid pace at which Agetech is evolving.

At present, there exists a severe shortage of geriatricians with the clinical understanding and experience to lead the first round of clinical trials to determine if these emerging interventions are effective and safe. Until this skills gap is closed, clinical geriatricians, scientists trained in the biology of ageing, and investigators with experience in early phase clinical trials and drug regulatory systems will need to join forces and work together to prove or disprove the effectiveness of senotherapy.

At this early stage, we are also unclear about the potential side effects of senolytic drugs or whether such observable changes at the cellular level are permanent. Only time will tell as larger-scale and more granular testing is carried out in a clinical setting on human patients.

On an ethical level, there are also important questions to consider and debate about intervening in one of lifes most fundamental and inevitable processes death.

Rich Quelch Global Head of MarketingOrigin

*Estimated at the time of conversion

Read more here:
The science of senolytics: breakthroughs in the future of ageing - Health Europa

Listen, then read the sermons of Martin Luther King Jr. Do so in parallel with apostolic fathers like Clement of Rome, Ignatius of Antioch, or Justin Martyr. You will hear the same prophetic voice and many of the same themes.

Against the heresy that Jesus was not really embodied, Ignatius pointed to his own coming martyrdom and real sufferings. King uses the suffering of African-Americans and his own personal troubles as also bearing the marks of Christ. Ignatius has his lions and King the lynching tree that point to the Cross.

The apostolic fathers were confident in God, if not always winning the daily fights. Clement points away fromimmediate successto more divine goals and purposes. King urges his congregation to walk with him even if the dream is deferred and the civil war in all our hearts between good and evil means that complete victory will not be possible in this life.

King in the pulpit is an American voice, but also an apostolic voice. Little wonder that a leader of the ancient church like Archbishop Iakovos found solidarity with the civil rights leader. Kingpreached the hard passages of Scripture as the fathers did, applying them to the situation, even the political situations of the day, asmany later church leaders had done. If Ambrose could rebuke an Emperor, then a King could certainly correct Governor Maddox!

King viewed his work in civil rights as anextensionof his Gospel ministry. He had no plans to run for office. He was a preacher:

You know, actually all that I do in civil rights I do because I consider it a part of my ministry. I have no other ambitions in life but to achieve excellence in the Christian ministry. I dont plan to run for any political office. I dont plan to do anything but remain a preacher. And what Im doing in this struggle, along with many others, grows out of my feeling that the preacher must be concerned about the whole man. Not merely his soul but his body. Its all right to talk about heaven. I talk about it because I believe firmly in immortality.

Kingpreached the need for salvation of the heart and a hope of Heaven. However,only a hereticcuts the soul off from the body or the body from the soul:

But youve got to talk about the earth. Its all right to talk about long white robes over yonder, but I want a suit and some shoes to wear down here. Its all right to talk about the streets flowing with milk and honey in heaven, but I want some food to eat down here. Its even all right to talk about the new Jerusalem. But one day we must begin to talk about the new Chicago, the new Atlanta, the new New York, the new America. And any religion that professes to be concerned about the souls of men (Well) and is not concerned about the slums that cripple the soulsthe economic conditions that stagnate the soul (Yes) and the city governments that may damn the soulis a dry, dead, do-nothing religion (Yes. Amen) in need of new blood.

Martin Luther King had the wisdom to know that a pastordoes doboth: he ministers to the soul and visits the hospital. He prays for the heart and the body. He feeds the mindandthe body. Ignatius would use his martyrdom to make a spiritual point for the readers of his epistles, but he also was rent by the lions. Justindemanded justice and made his case to the Emperor in hisApology.He wanted paradise, but he also wished an end of the persecution of the church. King was in that long tradition.

Gods pastors stand for justice: that which is to come informing whatshould be in the now!

With all that in mind, King had the standing to remind his congregation, and himself, that

InWhy Jesus Called a Man a Fool,Reverend Doctor King takes as his text the parable of Jesus is Luke 12:

Someone in the crowd said to him, Teacher, tell my brother to divide the inheritance with me.

14Jesus replied, Man, who appointed me a judge or an arbiter between you?15Then he said to them, Watch out! Be on your guard against all kinds of greed; life does not consist in an abundance of possessions.

16And he told them this parable: The ground of a certain rich man yielded an abundant harvest. 17He thought to himself, What shall I do? I have no place to store my crops.

18Then he said, This is what Ill do. I will tear down my barns and build bigger ones, and there I will store my surplus grain. 19And Ill say to myself, You have plenty of grain laid up for many years. Take life easy; eat, drink and be merry.

20But God said to him, You fool! This very night your life will be demanded from you. Then who will get what you have prepared for yourself?

21This is how it will be with whoever stores up things for themselves but is not rich toward God.

King notes that the Jesus does not condemn the man because he was rich. Jesus does not suggest his wealth was gained dishonestly. Why does God call the man a fool?

Number one, Jesus called this man a fool because he allowed the means by which he lived to outdistance the ends for which he lived. . .Somehow in life we must know that we must seek first the kingdom of God, and then all of those other thingsclothes, houses, carswill be added unto us. But the problem is, all too many people fail to put first things first. They dont keep a sharp line of demarcation between the things of life and the ends of life.

Wecould seek God. Wecould use the tools, wealth, and status we have accumulated to love our family, love our church, love our community, but insteadwe look to the tools, wealth and status.God does not need our tools, or even us. God gives us the tools so we may flourish in relationships: people over programs, principle over power.

King is not finished with us, yet!

Now, number two, this man was a fool because he failed to realize his dependence on others.(Yes)Now, if you read that parable in the book of Luke, you will discover that this man utters about sixty words. And do you know in sixty words he said I and my more than fifteen times? (My Lord) This man was a fool because he said I and my so much until he lost the capacity to say we and our. (Yes) He failed to realize that he couldnt do anything by himself. This man talked like he could build the barns by himself, like he could till the soil by himself. And he failed to realize that wealth is always a result of the commonwealth.

There isnothingwe do that should not lead us to honor other people. Every person with decent parents owes them an incalculable debt. Are we grateful? We are blessed to live in a place where we can build barns, but these are not things that we can do by ourselves! The people who make the wealth must share in the wealth. The state must not set up oppressive systems that rob and steal legally.

King has an example in mind:

In a larger sense weve got to see this in our world today. Our white brothers must see this; they havent seen it up to now. The great problem facing our nation today in the area of race is that it is the black man who to a large extent produced the wealth of this nation. (All right) And the nation doesnt have sense enough to share its wealth and its power with the very people who made it so.

Justice must be given to those who have built and worked. This is part of the message of the Old Testament prophets, but not the whole. If King had stopped here, then he would have been just another do gooder, a particularly powerful one, in his own first-rate talents. Yet King knew there was apower available that went beyond his own.

The fool never finds this power, healing, and hope.

King goes beyond the first two follies to the greatest foolishness of all:

Finally, this man was a fool because he failed to realize his dependence on God. (Yeah) Do you know that man talked like he regulated the seasons? That man talked like he gave the rain to grapple with the fertility of the soil. (Yes) That man talked like he provided the dew. He was a fool because he ended up acting like he was the Creator, (Yes) instead of a creature. (Amen)

I often read people commenting on Kings theology and referring back to his early writings in seminary. They miss the message of his sermons and the personal encounter with God that happened to him during the Civil Rights Movement.

King shares that as a pastor he felt called to aid with the bus boycott in Montgomery. He started the struggle, but then the ugly opposition began to wear on him. His own strength ran out and he turned to God. He had a powerful encounter with God one night very late after a particular ugly and threatening phone call. He needed relief, the theology and philosophy from the universities did not quite have the answer. I could not take it anymore . . .I was weak. He turned tomorethan his earthly Father and turned himself to God.I have to know God for himself. He prayed and heard God and lived in the promise that God would never leave him alone.

So when King testified it had power:

God is still around. One day youre going to need him. (My Lord) The problems of life will begin to overwhelm you, disappointments will begin to beat upon the door of your life like a tidal wave. (Yes) And if you dont have a deep and patient faith, (Well) you arent going to be able to make it.

The end of this sermon is anointed and must be heard. King shares the medicine he has found even in discouragement. The Holy Spiritrevives.

Listen here.

-

I have written about Rev. Dr. King (and his father!) several times. (Hopefully many of the obvious questions you might ask me regarding my opinions on Rev. Dr. King will be answered in the links.

As always with great books and leaders, especially on authors or topics on which I lack training, I begin as a student. First, I learn. Second, I apply what is true. Third, I consider what seems wrong. Fourth, I assume I am wrong for a goodly bit. Fifth, if I still think I am right, I express my ideas to a community to see!

Series part 1,2,3, 4,

The rest is here:
Taking Sermon Notes Why Jesus Called a Man a Fool- Listening to and Learning from the Reverend Doctor King (4/7) - Patheos