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What in Tarnation Is This "SpaceX Village" by the Starship Launch Site – Futurism
Posted: February 27, 2020 at 1:09 am
SpaceX Village
Business Insider spotted an, uh, intriguing job listing on SpaceXs careers: a project coordinator for a SpaceX Village situated next to the companys Boca Chica launch site for its colossal, in-development Starship rocket.
The puzzling, since-removed listing advertised amenities including volleyball tournaments, rock climbing, kayaking, and a spaceport lounge (restaurant and bar).
Gotta ask: what are you doing Elon? Its not clear, per BI, whether the purpose of the village is to house SpaceX employees in posh environs or to create a tourist attraction as a parallel revenue stream for the launch site.
Further complicating things, BI also reports that SpaceX is attempting to snap up land for the village from an existing retirement community on the site a process thats become acrimonious.
SpaceX has already bought out about half the residents, though others reportedly dont plan to move and have secured a law firm to help fight SpaceXs incursions.
One resident told BI that she found the job listing shocking and saddening, and described a community meeting at which Musk personally tried to convince residents to leave the area.
Elon was three feet from me, and he looked right down at me and he said, You wont want to live here, itll be inhospitable,' she told BI.
READ MORE: Elon Musks rocket company to build a SpaceX Village in Boca Chica [Business Insider]
More on Elon Musk: Elon Musk Disses Bill Gates
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Guy Builds Rocket to Prove Earth Is Flat, Crashes It, Dies – Futurism
Posted: at 1:09 am
Mad Mike
For years, a daredevil named Mike Mad Mike Hughes has been trumpeting his plan to launch himself in a homemade rocket in order to prove that Earth is flat.
This weekend, Hughes finally launched himself in his homemade rocket and crashed a minute later, dying in the wreck.
Had he survived Saturdays launch, the 64-year-old Hughes eventual plan had been to float his home-brewed rocket miles-high from the ground, using a balloon, then launching it to a height of 62 miles in order to film evidence that the Earth is actually flat a common conspiracy theory online.
I dont believe in science, he told the Associated Press in 2017, as he was planning an earlier launch.
It was a grim end for the amateur rocketeer, but in retrospect, one with an eerie foreshadowing by Hughes himself.
Sometimes, I feel like the cartoon character Wile E. Coyote, when he suddenly runs off a cliff, Hughes told the LA Times back in 2003. But its the price I pay for a life thats not boring.
READ MORE: Daredevil Mad Mike Hughes Killed In Crash Of Homemade Rocket [NPR]
More on rockets: SpaceX Is Going to Blow up a Falcon 9 Rocket Just After Launch
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Report: Two-Thirds of Coronavirus Infections May Be Undetected – Futurism
Posted: at 1:09 am
A new report by researchers at Imperial College London suggests that nearly two-thirds of new COVID-19 cases have gone undetected.
In a statement, lead researcher and author of the report Sangeeta Bhatia explained how they reached the (reasonably worrisome) figure:
We compared the average monthly number of passengers traveling from [outbreak epicenter] Wuhan to major international destinations with the number of COVID-19 cases that have been detected overseas. Based on these data, we then estimate the number of cases that are undetected globally and find that approximately two thirds of the cases might be undetected at this point.
Only a small subsection of confirmed cases show serious symptoms such as pneumonia, previous research has shown. Scientists are racing to understand the way the virus spreads, trying to figure out if the virus can be transmitted by patients who dont show any symptoms.
This estimate comes as news of the deadly virus rapidly spreading across the globe continues to pile up, with over 78,000 confirmed cases and over 2,300 deaths. New cases, particularly in Italy, South Korea, and Iran, have caused number of cases and deaths worldwide to spike in the last couple of days. Even the global market has felt the effects, causing investors to fear a global economic slowdown.
The spread outside of China has the scientists worried. We are starting to see more cases reported from countries and regions outside mainland China with no known travel history or link to Wuhan City, noted co-author Natsuko Imai in the statement. Hence why their report demonstrates the importance of surveillance and case detection if countries are to successfully contain the epidemic.
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The professionals who predict the future for a living – MIT Technology Review
Posted: at 1:09 am
Leah Fasten
Inez Fung
Professor of atmospheric science, University of California, Berkeley
Prediction for 2030: Well light up the world safely
Ive spoken to people who want climate model information, but theyre not really sure what theyre asking me for. So I say to them, Suppose I tell you that some event will happen with a probability of 60% in 2030. Will that be good enough for you, or will you need 70%? Or would you need 90%? What level of information do you want out of climate model projections in order to be useful?
I joined Jim Hansens group in 1979, and I was there for all the early climate projections. And the way we thought about it then, those things are all still totally there. What weve done since then is add richness and higher resolution, but the projections are really grounded in the same kind of data, physics, and observations.
Still, there are things were missing. We still dont have a real theory of precipitation, for example. But there are two exciting things happening there. One is the availability of satellite observations: looking at the cloud is still not totally utilized. The other is that there used to be no way to get regional precipitation patterns through historyand now there is. Scientists found these caves in China and elsewhere, and they go in, look for a nice little chamber with stalagmites, and then they chop them up and send them back to the lab, where they do fantastic uranium--thorium dating and measure oxygen isotopes in calcium carbonate. From there they can interpret a record of historic rainfall. The data are incredible: we have got over half a million years of precipitation records all over Asia.
I dont see us reducing fossil fuels by 2030. I dont see us reducing CO2 or atmospheric methane. Some 1.2 billion people in the world right now have no access to electricity, so Im looking forward to the growth in alternative energy going to parts of the world that have no electricity. Thats important because its education, health, everything associated with a Western standard of living. Thats where Im putting my hopes.
Dvora Photography
Anne Lise Kjaer
Futurist, Kjaer Global, London
Prediction for 2030: Adults will learn to grasp new ideas
As a kid I wanted to become an archaeologist, and I did in a way. Archaeologists find artifacts from the past and try to connect the dots and tell a story about how the past might have been. We do the same thing as futurists; we use artifacts from the present and try to connect the dots into interesting narratives in the future.
When it comes to the future, you have two choices. You can sit back and think Its not happening to me and build a great big wall to keep out all the bad news. Or you can build windmills and harness the winds of change.
A lot of companies come to us and think they want to hear about the future, but really its just an exercise for themlets just tick that box, do a report, and put it on our bookshelf.
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So we have a little test for them. We do interviews, we ask them questions; then we use a model called a Trend Atlas that considers both the scientific dimensions of society and the social ones. We look at the trends in politics, economics, societal drivers, technology, environment, legislationhow does that fit with what we know currently? We look back maybe 10, 20 years: can we see a little bit of a trend and try to put that into the future?
Whats next? Obviously with technology we can educate much better than we could in the past. But its a huge opportunity to educate the parents of the next generation, not just the children. Kids are learning about sustainability goals, but what about the people who actually rule our world?
Courtesy Photo
Philip Tetlock
Coauthor of Superforecasting and professor, University of Pennsylvania
Prediction for 2030: Well get better at being uncertain
At the Good Judgment Project, we try to track the accuracy of commentators and experts in domains in which its usually thought impossible to track accuracy. You take a big debate and break it down into a series of testable short-term indicators. So you could take a debate over whether strong forms of artificial intelligence are going to cause major dislocations in white-collar labor markets by 2035, 2040, 2050. A lot of discussion already occurs at that level of abstractionbut from our point of view, its more useful to break it down and to say: If we were on a long-term trajectory toward an outcome like that, what sorts of things would we expect to observe in the short term? So we started this off in 2015, and in 2016 AlphaGo defeated people in Go. But then other things didnt happen: driverless Ubers werent picking people up for fares in any major American city at the end of 2017. Watson didnt defeat the worlds best oncologists in a medical diagnosis tournament. So I dont think were on a fast track toward the singularity, put it that way.
Forecasts have the potential to be either self-fulfilling or self-negatingY2K was arguably a self-negating forecast. But its possible to build that into a forecasting tournament by asking conditional forecasting questions: i.e., How likely is X conditional on our doing this or doing that?
What Ive seen over the last 10 years, and its a trend that I expect will continue, is an increasing openness to the quantification of uncertainty. I think theres a grudging, halting, but cumulative movement toward thinking about uncertainty, and more granular and nuanced ways that permit keeping score.
Ryan Young
Keith Chen
Associate professor of economics, UCLA
Prediction for 2030: Well be moreand lessprivate
When I worked on Ubers surge pricing algorithm, the problem it was built to solve was very coarse: we were trying to convince drivers to put in extra time when they were most needed. There were predictable timeslike New Yearswhen we knew we were going to need a lot of people. The deeper problem was that this was a system with basically no control. Its like trying to predict the weather. Yes, the amount of weather data that we collect todaytemperature, wind speed, barometric pressure, humidity datais 10,000 times greater than what we were collecting 20 years ago. But we still cant predict the weather 10,000 times further out than we could back then. And social movementseven in a very specific setting, such as where riders want to go at any given point in timeare, if anything, even more chaotic than weather systems.
These days what Im doing is a little bit more like forensic economics. We look to see what we can find and predict from peoples movement patterns. Were just using simple cell-phone data like geolocation, but even just from movement patterns, we can infer salient information and build a psychological dimension of you. What terrifies me is I feel like I have much worse data than Facebook does. So what are they able to understand with their much better information?
I think the next big social tipping point is people actually starting to really care about their privacy. Itll be like smoking in a restaurant: it will quickly go from causing outrage when people want to stop it to suddenly causing outrage if somebody does it. But at the same time, by 2030 almost every Chinese citizen will be completely genotyped. I dont quite know how to reconcile the two.
Sarah Deragon
Annalee Newitz
Science fiction and nonfiction author, San Francisco
Prediction for 2030: Were going to see a lot more humble technology
Every era has its own ideas about the future. Go back to the 1950s and youll see that people fantasized about flying cars. Now we imagine bicycles and green cities where cars are limited, or where cars are autonomous. We have really different priorities now, so that works its way into our understanding of the future.
Science fiction writers cant actually make predictions. I think of science fiction as engaging with questions being raised in the present. But what we can do, even if we cant say whats definitely going to happen, is offer a range of scenarios informed by history.
There are a lot of myths about the future that people believe are going to come true right now. I think a lot of peoplenot just science fiction writers but people who are working on machine learningbelieve that relatively soon were going to have a human-equivalent brain running on some kind of computing substrate. This is as much a reflection of our time as it is what might actually happen.
It seems unlikely that a human--equivalent brain in a computer is right around the corner. But we live in an era where a lot of us feel like we live inside computers already, for work and everything else. So of course we have fantasies about digitizing our brains and putting our consciousness inside a machine or a robot.
Im not saying that those things could never happen. But they seem much more closely allied to our fantasies in the present than they do to a real technical breakthrough on the horizon.
Were going to have to develop much better technologies around disaster relief and emergency response, because well be seeing a lot more floods, fires, storms. So I think there is going to be a lot more work on really humble technologies that allow you to take your community off the grid, or purify your own water. And I dont mean in a creepy survivalist way; I mean just in a this-is-how-we-are-living-now kind of way.
Noah Willman
Finale Doshi-Velez
Associate professor of computer science, Harvard
Prediction for 2030: Humans and machines will make decisions together
In my lab, were trying to answer questions like How might this patient respond to this antidepressant? or How might this patient respond to this vasopressor? So we get as much data as we can from the hospital. For a psychiatric patient, we might have everything about their heart disease, kidney disease, cancer; for a blood pressure management recommendation for the ICU, we have all their oxygen information, their lactate, and more.
Some of it might be relevant to making predictions about their illnesses, some not, and we dont know which is which. Thats why we ask for the large data set with everything.
Theres been about a decade of work trying to get unsupervised machine-learning models to do a better job at making these predictions, and none worked really well. The breakthrough for us was when we found that all the previous approaches for doing this were wrong in the exact same way. Once we untangled all of this, we came up with a different method.
We also realized that even if our ability to predict what drug is going to work is not always that great, we can more reliably predict what drugs are not going to work, which is almost as valuable.
Im excited about combining humans and AI to make predictions. Lets say your AI has an error rate of 70% and your human is also only right 70% of the time. Combining the two is difficult, but if you can fuse their successes, then you should be able to do better than either system alone. How to do that is a really tough, exciting question.
All these predictive models were built and deployed and people didnt think enough about potential biases. Im hopeful that were going to have a future where these human-machine teams are making decisions that are better than either alone.
Guillaume Simoneau
Abdoulaye Banire Diallo
Professor, director of the bioinformatics lab, University of Quebec at Montreal
Prediction for 2030: Machine-based forecasting will be regulated
When a farmer in Quebec decides whether to inseminate a cow or not, it might depend on the expectation of milk that will be produced every day for one year, two years, maybe three years after that. Farms have management systems that capture the data and the environment of the farm. Im involved in projects that add a layer of genetic and genomic data to help forecastingto help decision makers like the farmer to have a full picture when theyre thinking about replacing cows, improving management, resilience, and animal welfare.
With the emergence of machine learning and AI, what were showing is that we can help tackle problems in a way that hasnt been done before. We are adapting it to the dairy sector, where weve shown that some decisions can be anticipated 18 months in advance just by forecasting based on the integration of this genomic data. I think in some areas such as plant health we have only achieved 10% or 20% of our capacity to improve certain models.
Until now AI and machine learning have been associated with domain expertise. Its not a public-wide thing. But less than 10 years from now they will need to be regulated. I think there are a lot of challenges for scientists like me to try to make those techniques more explainable, more transparent, and more auditable.
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Japanese mission to land a rover on a Martian moon and bring back a sample is a go – TechCrunch
Posted: at 12:49 am
A bold mission by the Japan Aerospace Exploration Agency (JAXA) to Mars two moons, including a lander component for one of them, is all set to enter the development phase after the plan was submitted to the Japanese governments science ministry this week.
Dubbed the Martian Moons Exploration (MMX) mission, the goal is to launch the probe in 2024, using the new H-3 rocket being developed by Mitsubishi Heavy Industries, which is expected to launch for the first time sometime later in 2020. The probe will survey and observe both Phobos and Deimos, the two moons that orbit the Red Planet, which are both smaller and more irregularly shaped than Earths Moon.
The MMX lander will park on Phobos, while the probe studies the two space-based bodies from a distance. This is the first-ever mission that seeks to land a spacecraft on one of the moons of Mars, and itll include a rover that is being developed by JAXA in partnership with teams at German space agency DLR and French space agency CNES.
The mission will include an ambitious plan to actually collect a sample of the surface of Phobos and return it to Earth for study which will mean a round-trip for the MMX spacecraft that should see it make its terrestrial return by 2029.
NASA is also planning a Mars-sample return mission, which would aim to bring back a sample from the Red Planet itself using the Mars 2020 six-wheel rover that its planning to launch later this year.
Both of these missions could be crucial stepping stones for eventual human exploration and colonization of Mars. Its possible that Phobos could act as an eventual staging ground for Mars missions, as its lower gravity makes it an easier body from which to depart for eventual astronauts. And Mars is obviously the ultimate goal for NASAs Artemis program, which seeks to first establish a more permanent human scientific presence on the Moon before heading to the Red Planet.
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Is There Life on Mars? NASA InSight Rover Detects Quakes – Science Times
Posted: at 12:49 am
(Photo : Pixabay)The moon as seen from the red planet - Mars
Mars, the red planet, is humming. The source of this alien music remains unknown as the quiet, constant drone periodically pulses with the beat of quakes rippling around the planet. Does this mean that there is life on Mars?
This Martian hum isdescribed in five studiesjust recently inNature GeoscienceandNature Communications.It was NASA's Interior exploration using Seismic Investigations, Geodesy and Heat Transport, or InSight, which detected seismic activity and ground vibration in the planet.
Since 1976, the InSight mission has only been NASA's eighth successful landing in Mars.On November 26, 2018,NASA's InSightmission landed in Elysium Planitia. InSight is used to develop a thorough understanding of the differentiation and subsequent thermal evolution of Mars that affects its surface geology and volatile process using information gathered by the InSight such as its interior structure, composition, and thermal state.
"It's such a relief to finally be able to stand up and shout, look at all this great stuff we're seeing," says principal investigator of the InSight mission, Bruce Banerdt.
Suzanne Smrekar, the deputy principal investigator of the Insight Mission said that one cannot make a model just from Earth but rather, more data points are still needed. "It's just super exciting that we some of these things, and that we are trying to understand Mars," she added.
Recording these movements could help scientists answer many questions that have remained unanswered for many decades now.Nicholas Schmerr, an assistant professor at the University of Maryland ponders on the question of life on Mars, "Can it support life, or did it ever? Life exists at the edge, where the equilibrium is off."
He added that like some areas here on Earth, we use energy from thermal vents deep in the ocean ridges to support life on our planet.
Schmerr also said that once the presence of the liquid magma is confirmed on Mars, scientists can locate which part of the planet is most geologically active and it might help future missions searching for potential life.
The InSight rover is said to be the first mission to focus directly on taking geophysical measurements of Mars that could provide an understanding of the red planet's interior structure and processes. The data is collected by both InSight and itsseismometer, an instrument used to detect and record ground motions like an earthquake.
Within 235 Mars days, the scientists were able to pick up 174 marsquakes. 150 of those were categorized as high-frequency events similar to the ones recorded on the moon. The other 24 ground motions were classed as low-frequency quakes.
An associate professor of geology in UMD and co-author of the study, Vedran Lekic said that we can identify geologic layers within Mars and determine the distance and location to the source of quakes based on how the different waves propagate. The 24 low-frequency quakes were really exciting because through them we will be able to know how to analyze them and extract information about the subsurface structure.
Since the InSight is much more improved than those used in the previous missions, it can also provide important information about the weather on Mars. This includes the so-called dust devils, which are whirlwinds the humans would have to muddle through if one day they decide to colonized Mars.
Dust devils form in the morning with help from the Sun and in the afternoon when atmospheric pressure drops, but their occurrence eventually stops in the evening. This is definitely a factor when humans finally decide to spend their everyday lives on another planet.
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These school students will talk to NASA astronauts onboard ISS tomorrow – International Business Times, Singapore Edition
Posted: at 12:49 am
NASA, the United States space agency has revealed that a group of students in Florida will get a chance to communicate with astronauts who are currently onboard the International Space Station (ISS). The space agency will broadcast the live earth to space calls on February 20, 2020, at 12.40 PM EST.
Which NASA astronaut will answer the question of students?
As per a recent press release published on the NASA website, astronaut Andrew Morgan will answer the questions of K-12 students from the School District of Lee County.
"Schools within the district have connected as part of a year-long program that celebrates 50 years since the Apollo 11 Moon landing and looks forward to NASA's return to the Moon through the Artemis program," wrote NASA on their website.
NASA astronauts have been conducting various experiments in the International Space Station for the past two decades, and they are playing a crucial role in giving valuable inputs which will help space scientists to explore deep nooks of the space. The upcoming Artemis space program aims to land humans on the moon again, as a strong platform to achieve the ultimate aim of Mars colonization.
Did a UFO recently pay a visit to the ISS?
Conspiracy theorists and alien enthusiasts were all pulled to a state of ecstasy recently as alien hunter Scott C Waring released a video that showed a UFO following the International Space Station for more than 20 minutes. After releasing the video, Waring claimed that he made this discovery from NASA's live feed.
Interestingly, the alleged flying vessel was moving at the speed as the ISS which moves at approximately 7.67 kilometers per second. At the end of the video, this mysterious flying vessel shot upwards and vanished from sight. Waring claimed that this video is an indication of extraterrestrial aliens from deep space visiting the earth.
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In Berlin, Indigenous artist Thirza Cuthand interrogates Canadas extraction economy – The Globe and Mail
Posted: at 12:49 am
Indigenous video artist Thirza Cuthand's NDN Survival Trilogy is showing at the Canadian embassy in Berlin.
The Canadian embassy in Berlin is a striking modern building on Leipziger Platz, constructed of some of the finest materials extracted from home, including Douglas fir and Manitoba limestone. Inside its elegant walls youll find envoys hard at work selling the idea of Canada to the largest economy in Europe. For the moment, though, youll also find something much more surprising: A pointed critique of Canadas extraction economy and its debilitating effects on Indigenous communities.
NDN Survival Trilogy is a trio of short films by artist and performer Thirza Cuthand, currently showing as part of the 70th Berlin International Film Festival. On opening night, guests crowded into the Marshall McLuhan Salon of the botschaft, or embassy, to watch Cuthands witty, personal take on extraction capitalism, artistic complicity, the role of gas masks in protest and sex play, and just who, exactly, is going to be invited to colonize Mars. In her opening-night speech, Cuthand, who is of Plains Cree and Scottish descent, gave a shout-out to the Wetsuweten protesters, as the screens behind her showed a series of chemical refineries and open-pit mines.
The protesters have given her hope, she says when she returns to the embassy for an interview the next day. As a child in Saskatoon, she saw her uncle Brad Larocque on the nightly news when he was part of the Oka protest (thats him standing nose-to-nose with a Canadian soldier in one of the defining images of the 1990 crisis). The same spirit is galvanizing Indigenous communities and their allies today, Cuthand says. What were seeing in Canada is that there are multiple ways things could change at any moment. Its a kind of joyful chaos that Im relying on.
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As we sit and talk, we can hear her voice echoing from the next room, a voiceover from the film Extractions. A group of viewers sits in the room named after one of Canadas most celebrated modern philosophers, having walked past the embassys waterfall and canoe to confront a less idealized version of Canada one in which Indigenous children are disproportionately taken into care by the government and the legacy of colonialism leaves scars on the land and communities.
The films are deeply personal, rooted in Cuthands identity as a queer Indigenous person who lives with bipolar disorder. The work is also, at times, quite hilarious. In the mock-documentary Reclamation, a group of Indigenous people, played by Cuthands friends, lament the mess theyve been left with after the rest of the planet has fled to Mars. I hope they find their god up there, one of them says, dryly.
That film, which was shot in Haida Gwaii and Saskatchewan, was inspired by Elon Musks grand plan to colonize Mars. You hear that and you think, who is really going to Mars? Its not going to be poor people. Probably not Indigenous people.
Without humour, she says, You just feel defeated and upset. It gives hope to people who are struggling. Ive talked to people who say that the film gives them hope. It may seem like were going through an apocalypse, but maybe theres something after that brings us back to a wholeness.
Hope is the bright thread that runs through all three films. In Extractions, Cuthand uses found footage of oil wells and ravaged landscapes to compare the extraction of natural resources to the extraction of Indigenous children from their homes and communities. But then, in the next scene, shes injecting herself with fertility drugs she wants to have a baby. Its a way of reclaiming hope and self-determination.
At the same time, she wrestles with the idea of complicity. Also in Extractions, she travels through the chemical valley that enriches Southwestern Ontario, on her way to give a workshop sponsored by a chemical company. And in the final video, Less Lethal Fetishes, she peers from behind a gas mask as she relates the story of a particular ethical dilemma. Last year, she was thrilled to be invited to show a film at the Whitney Biennial in New York until word got out that the vice-chair of the Whitney Museum, Warren Kanders, owned a company that manufactured tear gas. Artists in the Biennial staged protests, and Cuthand was torn: Should she stay in the show and help her career, or pull out in accordance with her beliefs? Fortunately for her, Kanders resigned from the Whitney before she had to make a decision, and her film was shown.
In Less Lethal Fetishes, Cuthand peers from behind a gas mask as she relates the story of an ethical dilemma surrounding a film festival in New York.
It was such a distressing time for me, Cuthand says. Did I make enough of a statement? As an artist who deals with politics in my work, I wondered how much responsibility I bear in a situation like that.
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Cuthands films are showing as part of the Berlinale, which runs until March 1. After that, shell return to her home base in Toronto, where shes working on her video game, A Bipolar Journey (level three features players in a group home fighting over a TV remote, and level four requires them to adjust their medication so theyre able to buy a hot dog) as well as working on a feature-film script about a queer Indigenous woman who can set fire to people and things with her mind. In other words, work that is funny and hopeful and political, all at once.
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How To Watch The Moon and Venus Switching Places in Upcoming Beautiful Cosmic Dance – Webby Feed
Posted: at 12:49 am
Home News How To Watch The Moon and Venus Switching Places in Upcoming Beautiful Cosmic Dance
While so many astronomers are seeking and finding outstanding sights way beyond our solar system and even beyond the galaxy, there are plenty of beautiful wonders very close to our planet that can amaze us forever.
One such event is represented by the Moon switching places with Venus on the night sky, an event that can be viewed tomorrow evening, February 27. The two celestial objects are creating a truly rare event only several hours after our beloved sun does its daily job and leaves the scene.
Venus and the Moon are the brightest objects in the night sky, and thats why it will be such a big deal to see them kissing each other.
Venus will be shining more brightly than usual since its in a period of several months called greatest elongation. The planet shall be at its furthest distance from the sun, and its expected to shine stronger until June.
You might ask yourself the following question: if Venus is so close, couldnt we send humans to it instead of thinking to colonize Mars? There is only one answer to the question, and that is a big NO!
Venus is the most hostile rocky planet from our solar system. It has hundreds of degrees Celsius at its surface, and it has a very thick and toxic atmosphere. The atmosphere from Venus contains mainly carbon dioxide, and thick clouds of sulfuric acid that are completely covering the planet. You can easily conclude that thats no place for humans to be. Religious people might say that the more they learn about Venus, the less they doubt the existence of Hell.
On the other hand, humans went to the Moon, and they plan to do it again in the current year.
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More Cell and Gene Therapy Facilities in the Hundreds are Needed – Genetic Engineering & Biotechnology News
Posted: February 26, 2020 at 8:55 am
The bioindustry will require more cell and gene therapy plants, says an expert, who says the facilities of the future must be automated, scalable, and flexible.
The number of cell and gene therapies entering clinical development has increased significantly in recent years. According to the Alliance for Regenerative Medicines (ARM) there are 1,066 such therapies in trials at present1, which is a 32% increase on the number of studies in 2014. But the surge in clinical activity has not been matched by an increase in production capacity says Darren Dasburg, a cell and gene therapy-focused consultant.
Hundreds of facilities will be needed to manufacture the treatments that are in play now, he said, adding that if you factor in the plants needed to make viral vectors that could exceed a thousand facilities.
The good news, Dasburg says, is that these facilities are more like labs than traditional large biopharmaceutical plants.
Viral vector capacity is critical to the cell and gene therapy sector. Vectors are hollow viruses used to insert genetic material into cells, both cells used in protein expression and cells used therapeutically. Various organisations have voiced concerns about industry capacity to make vectors. In 2018, for example, the Alliance for Advanced Biomedical Engineering said the scarcity of viral vectors could hamper expansion2. Since then the situation has improved, but it has not been resolved3. While viral vector production capacity in the contract services sector has increased, the expansion is still falling short of demand.
Partly this is because of the complexity of making the vectors, according to Dasburg.
Most viral vectors are produced using adherent manufacturing technologies which are expensive to operate, he explains. A vial of just 20 million cells can cost $2030K because it is so challenging to make.
To bring down costs, vector capacity still needs to increase, continues Dasburg, who predicted that biopharma will continue to rely on CDMOs for the foreseeable future.
Cell and gene therapy manufacturing is still a young industry. Biopharma is still figuring out what the ideal production facility should look like.
Building for flexibility and multipurpose manufacturing is important, Dasburg says, noting that explaining CDMOs and IP holders need to understand they are attacking rare genetic diseases and ailments where the therapy might be a third-line treatment. The numbers are often quite lower, and the treatments can be one and done. All meaning the companies of the future will be attacking many more areas of need.
In terms of technology, all cell and gene therapy facilities should feature sufficient isolator capacity, Dasburg says. Isolators are probably the number one investment to make. Too many people are trying to work five people in full dress in a small room attempting to manufacture in a hands-on traditional way when isolation and automation could help immensely.
Dasburg pointed to benchtop platforms capable of processing a single CAR-T patients treatment as an example of an innovative approach being used. These can be arranged in an array within a single ballroom-like facility providing 100% containment going from leukapheresis bag to treatment bag without any human intervention.
References1. alliancerm.org/wp-content/uploads/2020/02/CBX-Meeting-7-Feb-2020-FINAL.pdf2. aabme.asme.org/posts/virus-shortage-for-cell-therapies-creates-engineering-opportunity3. http://www.genengnews.com/insights/gene-therapy-dollar-is-waiting-on-viral-vector-dime/
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