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Category Archives: Transhuman News

Exploring the DNA Methylome in mCRPC Through NGS of Plasma DNA Specimens – Cancer Therapy Advisor

Posted: March 26, 2020 at 6:15 am

Results of a study that usednext-generation sequencing (NGS) to evaluate both the genome and methylome ofcirculating plasma DNA from patients with metastatic castration-resistant prostatecancer (mCRPC) revealed different subtypes of the disease associated withdifferent clinical courses. These findings were published in the Journal of Clinical Investigation.

Epigenetic changes to DNA, such as methylation of cytosine residuesthat are sequentially followed by guanine (ie, CpG dinucelotides) can bedetected through sequencing of DNA treated with sodium bisulfite, which reactswith unmethylated (but not methylated) cytosine.

Because DNA methylation/demethylation can affect gene expression, anunderstanding of the tumor methylome can provide information on gene regulationin different cancers.

In this study, circulating cell-free DNA collected from plasmaspecimens of 25 patients with mCRPC who had undergone treatment with either ofthe antiandrogen therapies, abiraterone, or enzalutamide within the prior 30days was treated with and without sodium bisulfite.

Subsequent NGS DNA analysis was performed using high-coverage targeted-or whole-exome sequencing of untreated DNA or, in the case of DNA pretreatedwith sodium bisulfite, a targeted enrichment approach based on previousknowledge of regions of DNA known to be associated with cancer. Plasmaspecimens were also collected from 2 healthy male volunteers.

The limited number of common genomic alterations in the plasmaspecimens of patients with cancer, the potential presence of clonalhematopoiesis in older patients, and the large number of plasma DNA fractionsfrom both normal DNA and tumor DNA (ie, either specific to the cancer or theprostate epithelium) were part of the rationale for evaluating both the genomeand methylome of plasma DNA specimens.

The primary aim of this study was to identify specific DNA methylationsignatures associated with mCRPC since results of previous studies showed that changesin DNA methylation in this setting were associated with a more aggressiveclinical course.

A key finding from this study was that theplasma methylome of patients with mCRPC was globally more hypomethylatedcompared with plasma specimens from healthy volunteers. Specifically, the studyauthors concluded that the main contributor to methylationvariance was strongly correlated with genomically determined tumor fraction, and that plasmamethylome analysis can accurately quantitate tumor fraction.

Among the tumor-specific DNA methylationsignatures observed in this study was an enrichment in hypomethylated androgenreceptor binding sequences associated with a gain in androgen receptor copynumber in patients with a more aggressive phenotype.

In their concluding remarks, the study authors noted that studies in more prostate cancer patients across the disease spectrum and healthy volunteers are required to validate our methylation subtyping signatures and confirm response prediction.

Reference

Wu A, Cremaschi P, Wetterskog D, et al. Genome-wide plasma DNA methylation features of metastatic prostate cancer [published online March 9, 2020]. J Clin Invest. doi:10.1172/JCI130887

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No. 486: On mega-moons, linear DNA and innovative immigrant services and yes, lots of coronavirus stuff – Innovate Long Island

Posted: at 6:15 am

The unusual: Welcome to Wednesday, dear readers, and the midpoint of another weird and wild workweek, as the Great Coronavirus Pandemic continues to reshape our world and the regional and global innovation economies scramble to keep up.

Leggo my Eggo: Move over, pancakes its the waffles day to shine.

Please celebrate alone: Its March 25 out there, the U.N.s International Day of Solidarity With Missing or Detained Staff Members, which is actually about U.N. employees who made the ultimate sacrifice, but seems oddly redefined today.

To mark the occasion or at least to make the quasi-quarantine more bearable you can choose from plenty of good eats: March 25 is International Waffle Day, Lobster Newberg Day (yes, please) and Pecan Day, which is more about a tree than the nut, but whatever.

Titanic discovery: Speaking of big deals, Dutch physicist, mathematician, astronomer and inventor Christiaan Huygens discovered Titan, Saturns largest moon, on March 25, 1622.

About half the size of Earth, Titan still ranks as the largest natural satellite in the Solar System.

Weapon of mass destruction: The Burnside Carbine, a breech-loading rifle that did plenty of damage during the American Civil War, was patented by inventor Ambrose Burnside on this date in 1856.

Also, Englands Queen Elizabeth I granted Sir Walter Raleigh a patent to create the colony of Virginia essentially, the exclusive right to colonize America on this date in 1584, but were not sure that one stuck.

Blowing in the wind: The worlds first successful tornado forecast was made on this date in 1948, when Maj. Ernest Fawbush and Capt. Robert Miller issued a warning hours before a devastating twister struck Oklahomas Tinker Air Force Base.

Fawbush and Miller went on to develop tornado-forecasting technologies still in use today.

Lennons linens: John and Yoko, protesting peacefully.

Pillow talk: John Lennon and Yoko Ono kicked off their first Bed-In for Peace on March 25, 1969, at the Amsterdam Hilton Hotel, promoting world peace from between the sheets.

Let the Wiki win: And it was this date in 1995 when the first wiki a webpage that can be edited by users became a thing, with the launch of Ward Cunninghams WikiWikiWeb.

This is: Howard Cosell (1918-1995) the blustery, popular and influential radio and television sportscaster/print journalist of the mid-20th century, who also enjoyed a successful acting career (mostly playing himself) would have been 102 years old today.

Equal sign: Steinem, cofounder of the Womens Media Center.

Also born on March 25 were educator William Wait (1839-1916), who invented a writing system for the blind that predated Braille; Great Necks own Eileen Ford (1922-2014), co-founder of the Ford Modeling Agency; British anthropologist Dame Mary Douglas (1925-2007), a leading scholar of anthropological classifications; iconic American novelist and short-story writer Flannery OConnor (1925-1964); and retired American astronaut Jim Lovell Jr. (born 1928), steady hand at the wheel of the treacherous Apollo 13 mission.

No Ms.-taking her: And take a bow, Gloria Marie Steinem the American journalist and social/political activist, whose name has long been synonymous with feminism, turns 86 today.

Send well wishes for the Ms. magazine cofounder, the originator of historys most-overused meme and all the other March 25 innovators to editor@innovateli.com and please include a story tip or calendar item. Remember, failure is not an option (second-most-overused meme).

About our sponsor: Nixon Peabody is an international law firm with an office in Jericho that works with clients who are building the technologies and industries of the future. We have the experience necessary to drive your business forward and help you negotiate risks and opportunities related to all areas of business and the law, including startup work, private placements, venture capital and private equity, IP and licensing, labor and immigration and mergers and acquisitions.

BUT FIRST, THIS

Scoping mechanism: Applied DNA Sciences is not naming names, but a new research agreement with a global top-20 pharmaceutical company promises a giant leap forward for its LineaRX spinoff, according to the Stony Brook-based biotech.

Applied DNA a leader in polymerase chain reaction-based DNA manufacturing for product-authenticity solutions, nucleic acid-based biotherapeutic development and other cutting-edge uses said this week the new collaboration would evaluate the full scope of the companys linear DNA platform, already an increasingly useful tool in everything from the COVID-19 fight to textile supply-chain security.

The best may be yet to come, according to Applied DNA President and CEO James Hayward, who noted particular interest from the unnamed Big Pharma partner in potential expansions of its modified T-cell therapeutic programs, key to treating blood cancers like leukemia and lymphoma. This agreement validates our linear DNA platform strategy and evidences growing interest in our manufacturing platform, Hayward said, noting attention from the highest tier of pharmaceutical manufacturers.

Jeffrey Reynolds: Island integrator.

Welcome to Long Island: One of the regions leading community organizations has scored a chunky grant to support assistance programs for recent U.S. immigrants.

The Mineola-based Family & Childrens Association has earned a $139,209 grant from the Mother Cabrini Health Foundation a New York City-based nonprofit on a mission to meet the health needs of statewide residents and communities earmarked for the FCAs Newcomers Resource Center, which is being created to guide recent arrivals and immigrants already living here toward becoming successful members of the Nassau County community.

Featuring referral services, counseling, school advocacy, legal guidance, vocational training, short-term childcare services and more, the Newcomers Resource Center will be a game-changer for new residents struggling to find their way on Long Island, according to FCA President and CEO Jeffrey Reynolds. We look forward to seeing life-changing opportunities present themselves for these families, Reynolds said.

TOP OF THE SITE

One-stop coronavirusing: Welcome to your Pandemic Primer, a running log of Long Island-flavored innovations and breakthroughs from the COVID-19 front.

Plans in motions: Businesses around the world were caught flatfooted by the WFH restrictions of the global pandemic but not Nixon Peabody.

Coming soon: The National Guard will pitch in as emergency hospitals rise on the Stony Brook University and SUNY Old Westbury campuses.

VOICES

Pandemic squared: COVID-19 affects all, but for public relations professionals who must still create non-coronavirus messaging without seeming oblivious or insensitive the challenge is double. Media maestro David Chauvin weighs in with advice for marketers of every stripe.

STUFF WERE READING

Under fire: From the New York Times, the importance of leadership in a crisis, according to military brass whove been there.

Underwhelmed: From NBC News, why the U.S. military would do more good in the coronavirus fight with a different commander-in-chief.

Udder-whelmed: From Atlas Obscura, the birth of cowcohol vodka made from whey, a common dairy-production byproduct.

RECENT FUNDINGS

+ Diligent Robotics, a Texas-based AI company building socially intelligent workforce robots, raised $10 million in Series A funding led by DNX Ventures, with participation from True Ventures, Ubiquity Ventures, Next Coast Ventures, E14 Fund, Promus Ventures and Grit Ventures.

+ Honorlock, a Florida-based online proctoring service for educational institutions to protect academic integrity in online assessments, raised $11.5 million in Series A funding led by Neil Sequeira from Defy Partners.

+ E25Bio, a Massachusetts-based developer of rapid diagnostic tests, raised $2 million in financing. Khosla Ventures made the investment.

+ ZincFive, an Oregon-based provider of nickel-zinc batteries and solutions, raised $13.1 million in Series C funding. The round was led by 40 North Ventures.

+ RoadRunner Recycling, a Pennsylvania-based technology platform built for commercial recycling, raised $28.6 million in Series C financing co-led by e.ventures and Greycroft, with additional participation from Franklin Templeton, Adams Capital Management and FJ Labs.

+ Quit Genius, a California-based personalized digital therapeutic platform for addictions, raised an additional $11 million in Series A funding led by Octopus Ventures, with participation from Y Combinator, Startup Health, Triple Point Ventures, Serena Ventures and Venus Williams, among others.

BELOW THE FOLD

Make it so: A Next Generation marathon might cheer you up.

Dont worry: Why stressing out over COVID-19 is the last thing you should do.

Be happy: Yale Universitys popular happiness course, now online and free.

And watch some TV: Comforting shows to stream your way through the pandemic.

Also keeps you chill: Nixon Peabody, one of the amazing firms that support Innovate LI, has launched a multidisciplinary Coronavirus Response Team to help your business weather the storm. Real-time legal updates and other pandemic resources are just a click away.

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No. 486: On mega-moons, linear DNA and innovative immigrant services and yes, lots of coronavirus stuff - Innovate Long Island

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Review: Witch Prophet’s DNA Activation shows the power of family in dark times – NOW Magazine

Posted: at 6:15 am

Rating: NNNN

Witch Prophet begins her sophomore LPwith a question that feels more relevant than ever: Where do we go from here when the whole world is falling through darkness and we cannot see the light?

Ayo Leilani turns her focus to her family and draws inspiration from her Ethiopian/Eritrean heritage as well as mythology and biblical stories. Across the albums 10 tracks each named after a family member Leilani, alongside co-producer Sun Sunand a host of contributing artists, carves out space to reflect on familiar history and to try and unravel the knotty feelings of love and pain that go hand-in-hand with this reflection.

DNA Activation works best as a unit. Each song has a similarly hazy soundscape that mixes R&B, hip-hop and jazz sounds while the voice of Leilani, who sings in English, Amharic and Tigrinya, surfs lightly above. But cohesion doesnt mean uniformity: Tesfayis an assured, enlivening track thanks to a delicious pairing of a playful bassline and the confident wails of Karen Ngs saxophone, a welcome addition on a few of the albums tracks. Darshanand Etmet(the latter featuring Brandon Valdiviaon flute)are downtempo hip-hop tracks made for late-night hangs with whoever you define as family.

On nearly every song, Leilani clings with purposeto a phrase and repeats it like a mantra ora reminder: Oh my god (Elsabet) orBow down to the queen (Makda). On Ghideon, a song named after Leilanis father, each repeated cut down feels like the swing of an axe as it chops off a limb of the family tree.

DNA Activation is a warmly hypnotic escape that arrives when we need it most. It also serves as a reminder that family can sustain you even when the world is falling through darkness.

Top track: Tesfay

@LStanely24

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Burglar who fled Jesmond home in stolen Audi caught out by DNA on airbag – Chronicle Live

Posted: at 6:15 am

A burglar who snuck into a student home is now behind bars after his DNA was discovered on the airbag of a stolen Audi.

On May 10 last year, Gary Hearn targeted a student property on Ashleigh Grove in Jesmond, Newcastle, stealing a range of items including a laptop, decks, a Bose speaker and a sports bag.

He then fled the scene at around 8.30pm in an Audi A4 belonging to one of the students.

Later that night, as he was driving around in the stolen car, the 35-year-old crashed into a taxi on Grasmere Avenue, in Walker. But despite causing considerable damage to the Ford Tourneo, Hearn once again fled the scene.

In the meantime, the student had returned home to find his front door ajar and reported the burglary, with an investigation launched by officers.

It wasnt long before detectives located the stolen Audi which had been abandoned on Parsons Avenue, in Walker. The forces Scientific Support Unit carried out forensic tests on the airbag which came back as a match to Hearn.

Hearn, of Oban Gardens, Byker, appeared at Newcastle Crown Court on March 16 where he pleaded guilty to burglary and theft of a motor vehicle.

He was sentenced to 35 months - almost three years - behind bars.

Detective Sergeant David Lumsden, of Northumbria Police, said: Hearn has shown himself to be nothing more than an opportunistic thief he showed a blatant disregard for the law and for other peoples possessions.

Burglary is an intrusive crime that can have a lasting impact on those who fall victim to it, as well as the wider community as a whole. Thats why we will continue to work hard every day to ensure criminals like Hearn are caught and brought to justice.

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China’s Media Censorship Could Cost Thousands of Lives: Journalism Watchdog – Newsweek

Posted: at 6:14 am

Thousands of lives could have been saved if China allowed its media freedom to operate independently, the Reporters Without Borders (RSF) organization has claimed.

RSF published a statement Tuesday detailing how Chinese authorities suppressed whistle blowers and early warnings of the COVID-19 virus outbreak, which has since spread across the globe and killed more than 19,000 people.

"Without the control and censorship imposed by the authorities, the Chinese media would have informed the public much earlier of the severity of the coronavirus epidemic, sparing thousands of lives and perhaps avoiding the current pandemic," the RSF statement argued.

The pandemic originated in the central Chinese city of Wuhan in December, likely at a so-called "wet market" where live and dead animals are sold.

The Chinese Communist Party was accusedby President Donald Trump, Secretary of State Mike Pompeo and othersof silencing whistleblowers and hiding the severity of the outbreak, which soon spread beyond its borders.

Tight restrictions appear to have stemmed the spread of COVID-19 in China, and officials have said that the peak of the outbreak has passed. There have now been more cases and deaths outside China than inside.

But RSF cited a University of Southampton analysis published earlier this month that argued the number of coronavirus cases in Chinawhich is rated 177th out of 180 in the 2019 RSF World Press Freedom Indexcould have been reduced by 86 percent if the restrictive measures implemented on January 20 had been put in place two weeks earlier.

RSF argued that the first red flag was missed in October, when the Johns Hopkins Center for Health Security ran a simulated coronavirus pandemic alongside the World Economic Forum and the Bill and Melinda Gates Foundation.

The simulation produced 65 million deaths in 18 months, a result RSF argued would have sparked interest and concern in China if media organizations were able to cover it or citizens were able to see it online.

Local Wuhan officials failed to inform the media of the outbreak, even when there were dozens of patients suffering the same mysterious illness and symptomsseveral of whom had visited the Huanan fish market where the virus is believed to have originated. The market was closed on January 1.

Dr. Lu Xiaohong was among the first medical workers to suspect that something seismic was occurring, having been told of multiple infections among staff at Wuhan City Hospital as early as December 25.

RSF argued that if journalists' sources did not face such strict punishments for speaking out, Lu may have raised the alarm and forced officials to acknowledge the problem.

A group of whistleblowers tried to do exactly that, but were arrested for circulating "false rumors" on January 3. Eight of these whistleblowers have since died of coronavirus.

Though China officially alerted the World Health Organization to the situation on December 31, officials moved to censor a number of related keywords on the country's tightly-controlled billion-user WeChat platform.

By January 5, a team at the Shanghai Public Health Clinical Centre had sequenced the virus, but the vital information was not released publicly. Only on January 11the day the first coronavirus death was confirmeddid researchers leak the genome to open source platforms, handing the international community a priceless element in their nascent hunt for a vaccine.

The first case outside China was confirmed on January 13. RSF argued that the international community "would have taken stock of the crisis and better anticipated it" if Chinese media had been able to cover the issue since December. This may have slowed its spread and avoided "its transformation into a pandemic," the organization argued.

Newsweek has contacted the Chinese embassy in Washington, D.C. for a response to RSF's assertions.

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A champion in Murmansk media quits because of censorship – The Independent Barents Observer

Posted: at 6:14 am

Gorodetsky is a veteran in Murmansk media. In 2005 he established the B-Port, a news agency that has developed into a leading newsmaker in the north Russian region.

Since then, much has changed in regional journalism.

On the 25th March, the director and editor-in-chief announced that he is leaving the company he created almost 15 years. The reason is growing censorship from regional authorities, he explains in a post on Facebook.

The situation is such that our news arena is rapidly changing, and not in a good direction, Gorodetsky says.

The opinions and posts that are published on our site suddenly have become unwanted and a source of irritation, he adds.

According to the editor, his news agency is now increasingly often contacted from above and told to remove or change contents.

He argues that there have appeared absurd prohibitions and strange limitations and that it now is considered undesired to express personal opinions that diverge from settled truths.

The news team at B-Port will continue to deliver contents, but now without Gorodetsky.

Over many years I have invested not only power and resources, but also parts of my soul. And of course I will not allow my soul to be wiped by my feet.

According to MMK News, Gorodetsky owns the B-Port together with regional politician Igor Morar. Reportedly, a recent issue of conflict has been the news agencys coverage of the coronavirus.

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The face of crypto censorship on Wikipedia? – Decrypt

Posted: at 6:14 am

Here we go again. When you're a cryptocurrency that has seen 99% of its value vanish since the crypto bubble of 2017 to early 2018, getting an articleor even a mention in Wikipediacan feel like an insurmountable task. Or it can feel like censorship.

To Charles Hoskinson, it feels like the latter. The founder of Cardano has taken to YouTube to complain about Wikipedia. In a 9:46-minute rant, he accused the community-run free encyclopedia of bias. He claimed that the site is hostile toward cryptospecifically, his crypto projectand threatened legal action.

At issue is a proof of stake Wikipedia page, which Hoskinson claims is badly out-of-date. He said that when certain Cardano community members (he didnt specify who they were) tried to edit the page to include a blurb on Ouroborosthe consensus algorithm that powers CardanoWikipedia volunteers promptly removed the changes.

This is another example of the existential danger to an industry when people rely on things that appear to be open but are actually controlled by a few people who are incredibly biased and who are not accountable to anyone else, he said.

Few people? Who is he referring to? We discovered that one of the offending editors is nocoiner gatekeeper David Gerard. Other crypto projects, notably Decred (which has since slipped five more ladder rungs to 41st cryptocurrency), have complained that Gerard has barred them from Wikipedia.

Yes David Gerard is the one who has been a censor. It has been going on for years since the Ethereum days. I don't know why he hates us so or where his ego comes from, Hoskinson, former CEO of Ethereum, tweeted.

Gerard, though, is not the only editor who has taken issue with the Ouroboros blurb.

In recent days, three other Wikipedia editors also removed the blurbonly to have Cardano members put it back in againwhile a fourth editor removed proposed links to the blurb.

Why? Wikipedia says the content is promotional and therefore verboten.

The text proposed above is hardly neutralit talks about diligent research and innovative features which lend credibility to it's[sic] claim, etc., an editor named Bonade wrote on Tuesday. That kind of wording is not appropriate in an encyclopedia, even if the content should be acceptable.

Hoskinson countered (during his video rant, which he also posted to Twitter) thats not the only instance where editors targeted Cardano. A Cardano Wikipedia page even enjoyed a brief existence before Wikipedia editors rudely snuffed it out in November 2018.

Thats unfair, especially, when historically, weve had a market cap larger than SpaceX, he argued, referring to Elon Musks aerospace project. It is very anti-crypto.

Hoskinson claimed the edits are unsubstantiated and hostile. What does Wikipedia want that the Cardano community isnt proffering up? Tell us the standard and well meet that standard...We are not afraid to have a debate. We are not afraid to represent our technology, and our progress," he said.

In fact, Wikipedia, which has been around since 2001, does have well-documented standards. For starters, to warrant an article on the site, a topic has to be notable. That means the topic needs to have significant coverage in reliable sources that are independent of the subject. Reliable sources include mainstream press and peer-reviewed academic presentations.

The way to get coverage in Wikipedia is to have substantial coverage in a high-quality mainstream sourcenot the crypto press, Gerard told Decrypt, which is crypto press. [ex, Josh Quittner, founding editor: What are we, chopped liver, Gerard?"]

Crypto media does not count as a reliable source because they're really about advocacy: promoting their hodlings, he wrote in an article detailing why Wikipedia editors are harsh on sourcing for crypto articles. Crypto projects are an ongoing firehose of spam, he wrote.

It is quite possible Cardano is adequately sourced; the next stage is an article entirely sourced from good sources, Gerard said.

But from Hoskinsons position, thats simply unjust. Where coins like Spankchain can have an article on Wikipedia. A lot of other cryptocurrencies and top 20s apparently have articles, and thats perfectly fine. But then we are not allowed to have an article for some reason, even though we have been mentioned by the US Congress. Weve been mentioned by the New York Times, the Wall Street Journal, and the Financial Times.

Spankchain does not have a Wikipedia page. We tried to find the reliable sources that Hoskinson listed but we couldnt find anything in mainstream beyond the slightest passing mention.

Meanwhile, citing Hoskinsons posted videoand the potential for a flood of Cardano fans to now rush in and defend the storyGerard has put the proof-of-stake article under extended confirmed protection. That means that from now on, it can be edited only by those who have at least 30 days' tenure on Wikipedia and have done 500 edits. And another editor has initiated an investigation into sockpuppetry, meaning one person in the Cardano community may be making edits to Wikipedia under different aliases, which Wikipedia does not allow.

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Apple Helps China Censor Citizens By Pulling The Plug On A Keyboard App That Encrypted Text Messages – Techdirt

Posted: at 6:14 am

from the don't-be-Big-Brother's-little-brother dept

China keeps being China, despite all the problems it has at home. The coronavirus traces back to Wuhan, China, and it has become clear the Chinese government is doing what it can to suppress reporting on the outbreak.

The country has a fine-tuned censorship machine that works in concert with its overbearing surveillance apparatus to ensure the government maintains control of the narrative. "Ensures" is perhaps too strong a term because, despite its best efforts, information always leaks out around the edges.

Citizens of China have found numerous ways to dodge censorship and surveillance over the years. But they're not being helped much by American companies, which have more often than not complied with government demands for apologies, takedowns, and other efforts that ensure access to the Chinese market at the expense of their Chinese users.

The latest news is more of the same. A clever keyboard app that encrypted messages has been nuked from the Chinese app store by Apple following a takedown demand from the Chinese government.

Apple yesterday removed Boom the Encryption Keyboard, an app that allowed Chinese internet users to bypass censorship, from the China app store, according to its developer.

[...]

According to an email sent by Apple to [app developer] Wang Huiyu, the app was removed because it contained content that is illegal in China. The app is still available in other regions, including Hong Kong, he said.

Boom encrypted messages by changing the originating English or Chinese to a blend of emoji, Japanese, and Korean characters. To decrypt the messages, users simply copied the characters sent to them, which were reverted to their original state on the keyboard below. Not enough to thwart targeted surveillance, but more than enough to dodge blanket censorship efforts like keyword blacklists.

The app's developer suspects Boom was targeted by the Chinese government because it was being used to spread an article about the virus that was censored by the government shortly after its publication.

The article in question is an interview with Ai Fen, a Wuhan doctor who said she was reprimanded for alerting other people about the novel coronavirus. The article, published on March 10 by Chinas Ren Wu magazine, was deleted within hours of its publication. Various versions of the article, including those reproduced in emoji, English, and even Hebrew, emerged after the deletion as people scrambled to save Ais story

This is the sort of information American companies should be helping to spread, not shutting down at the behest of the parties who want to see this information buried. If this were a one-off, it would be worrying. But it's just another data point in a long string of incidents where American tech companies have endangered users in foreign countries, seemingly for the single purpose of maintaining market share.

Filed Under: app store, boom, censorship, china, codes, content moderation, emoji, encryption, keyboardCompanies: apple

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German government prepares for internet censorship and deployment of the armed forces – World Socialist Web Site

Posted: at 6:14 am

By Ulrich Rippert 23 March 2020

The COVID-19 pandemic is highlighting the class character of politics. The health care system has been cut to pieces, hospitals privatised and trimmed for profit, laboratory capacities and nationwide treatment options massively restricted.

Despite warnings from China, no preparations have been made to protect the population. The government cares only about the interests of big business and is making unlimited financial resources available to corporations and banks. Although the danger of the virus was known, and public life has been drastically restricted, many workers are being forced to continue their work without adequate protection.

Resistance is growing against this criminal irresponsibility by the government and employers. Various opposition groups are forming on the internet to refute government propaganda and describe and fight against the dramatic conditions in hospitals, rescue stations, care facilities and factories, but also the devastating effects of government measures on workers in precarious employment.

Politicians have responded to this opposition with calls for censorship and dictatorial measures.

At the beginning of the week, Lower Saxonys state Interior Minister Boris Pistorius (Social Democratic Party, SPD) called for sanctions against the distribution of so-called fake news in connection with the Coronavirus pandemic. He demanded that the government urgently intervene, saying, It must be prohibited to publicly spread false allegations about the supply situation of the population, medical care or cause, ways of infection, diagnosis and therapy of COVID-19.

According to Pistorius, the government must examine whether bans could already be based on the infection protection law. If not, the penal code or the law on administrative offences should be amended as quickly as possible.

The greatest misinformation currently being spread comes from the government itself. It claims that the German health care system is well prepared for the spread of the pandemic, and no one need worry. For weeks, the government played down the dangers.

Now that reality has refuted its propaganda, any criticism of it is to be criminalised and suppressed. If Pistorius has his way, the government will rigorously enforce its monopoly on information and opinion. This is a call for censorship and dictatorship.

Pistorius has long been known as a right-wing social democrat in the tradition of Gustav Noske, who during the November Revolution in 1918 allied with the German army and far-right Freikorps to suppress working-class opposition to the bourgeois order.

For seven years as Lower Saxonys interior minister, he has been advocating a strict right-wing course against refugees and for stepping up the repressive powers of the state. In summer 2017, he presented an SPD position paper on domestic policy, the central point of which was strengthening the federal police force financially and with more personnel. One year later, more than 10,000 people demonstrated in Hanover against the new police law of Lower Saxony, which Pistorius had drafted, because it massively expands the powers of the security authorities while at the same time restricting elementary civil rights.

With his call for censorship and police-state measures, Pistorius speaks for a party that has always responded to crisis situations and resistance from the population by calling for the strong state and dictatorial measures. Pistorius comes from the same political stable as former German Chancellor Gerhard Schrder, who brutally smashed up the welfare systems with the Hartz laws. For the past three years he has also been living in a relationship with Schrders fourth wife, Doris Schrder-Kpf, from whom the former chancellor separated in 2015.

There is no doubt that the fight against the pandemic requires the restriction of social contacts and individual freedom of movement. However, it must not be allowed that the conditions for a dictatorship are created under the slogan necessity knows no law! The coronavirus pandemic, its ominous health, social and economic consequences and the drastic measures required to combat it raise the question of who exercises power and controls the statethe financial oligarchy or the working class?

The ruling class everywhere is trying to use measures against the Corona crisis to strengthen its power. According to information from DPA and Der Spiegel, the president of the Bundestag (federal parliament), Wolfgang Schuble (Christian Democratic Union, CDU), for example, has proposed to the leaders of the parliamentary groups that they expand the Emergency Laws by amending the constitution.

The Emergency Laws, which were passed in May 1968 in the midst of the largest workers strikes and student protests of the post-World War II period, give the state quasi-dictatorial powers in crisis situations (natural disaster, uprising, war). Among other things, they allow for the Bundestag and the Bundesrat (the upper chamber of parliament) to be replaced by an emergency parliament, the Joint Committee. This committee consists of only 48 selected members but has the full powers of both chambers of parliament and would thus largely override the existing parliamentary system. Schuble has now brought up the idea of including a similar regulation in the constitution for the case of an epidemic.

The deployment of the Bundeswehr (armed forces), which Defence Minister Annegret Kramp-Karrenbauer announced at a press conference on Thursday, must also be seen in this context. For the time being, the focus is on logistical tasks. The Bundeswehr has five hospitals of its own, 3,000 doctors, mobile military hospitals as well as logistics and transport capacities that can be used in the fight against the virus.

But Kramp-Karrenbauer has more in mind. In addition to the deployment of up to 50,000 soldiers, there is also talk of mobilizing 75,000 reservists. At the press conference, the defence minister emphasized that the troops will only be properly deployed when the civilian authorities and organizations have reached the end of their capabilities. She claimed that in the area of security and order, assistance from the military would only be available under strict conditions, but in a daily order to the troops she wrote, We will help with health care and, if necessary, with ensuring infrastructure and supplies as well as maintaining security and order.

Chief of Staff Alfons Mais wrote to soldiers saying the Bundeswehr now had the task of maintaining operational readiness for any required support. We are at the beginning of a road whose direction and length we cannot yet estimated, he declared.

In Bavaria, the conservative state government declared a disaster situation last Monday. This enables them to take far-reaching measures against the spread of the coronavirus and to call on citizens to help in the form of services, material and work. However, the disaster situation also means a far-reaching encroachment on democratic rights, which can be used to suppress social and political opposition. The working class must be on its guard.

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Encryption app to avoid coronavirus censorship removed by Apple in China – Quartz

Posted: at 6:14 am

Apple yesterday removed Boom the Encryption Keyboard, an app that allowed Chinese internet users to bypass censorship, from the China app store, according to its developer.

Wang Huiyu, a New York-based Chinese citizen in his 20s, told Quartz that he developed Boom together with one of his university classmates during the outbreak of the coronavirus. Part of the motivation for Wang to develop the app, which went live on Feb. 15, was to offer people a chance to counter rigid online surveillance, and to provide them with an entertaining private messaging app.

According to an email sent by Apple to Wang, the app was removed because it contained content that is illegal in China. The app is still available in other regions, including Hong Kong, he said.

I designed the app because I wanted to remind people of the importance of privacy, and my target customers are people born after 1995 or 2000. I feel those under 20 will be able to accept new things and ideas the fastest, said Wang.

Boom encrypts text, both in Chinese and English, by turning them into emoji or Japanese or Korean characters, as well as rearranging lines of text in random order. The receivers of such messages can decrypt them by copying the emoji or characters using the app, with the original text then displayed automatically on the keyboards interface. As Chinas blanket online censorship relies heavily on the detection of key words or even pictures containing sensitive words, apps like Boom can help users avoid such scrutiny.

Another app developed by Wang, which offered animated wallpapers featuring political figures including former Chinese leader Jiang Zemin, was also removed (link in Chinese) from Apples mainland China app store on the same day as Boom, he said.

Apple has removed apps from its China app store in the past for containingillegal content. Among the apps that have been pulled were Quartzs news app, which was removed from the China app store last year.

Apple did not immediately reply to a request for comment.

While most apps that enable encrypted messages and communications have long been banned in China, Wang said he suspects Boom drew the attention of authorities because of the way Chinese internet users quickly moved to preserve a particular coronavirus-linked article from being scrubbed by censors recently.

The article in question is an interview with Ai Fen, a Wuhan doctor who said she was reprimanded for alerting other people about the novel coronavirus. The article, published on March 10 by Chinas Ren Wu magazine, was deleted within hours of its publication. Various versions of the article, including those reproduced in emoji, English, and even Hebrew, emerged after the deletion as people scrambled to save Ais story, part of a broader wave of efforts by internet users in China to prevent censors from removing crucial stories and memories related to the epidemic. Wang said downloads of Boom from mainland China surged after the incident.

Apple has been repeatedly accused of bowing to China by removing apps, such as a Hong Kong live map app that allowed protesters to crowdsource police movements during last years protests in the city.

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