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Category Archives: Transhuman News
Indians do not have genetic protection against coronavirus, published research incorrectly interpreted – Alt News
Posted: April 7, 2020 at 4:08 pm
An opinion piece published on Livemint by Sandipan Deb claimed that COVID-19 will not affect Indians as they have the genetics for a sturdier immune system.
When questioned on Twitter, the author, also a founder of Swarajya Magazine, cited a Nature Asia article titled, More immunity in Indian genes, as his source.
The Nature Asia article (2008), based on the research study by Du and colleagues (2008), published in the journal Genes & Immunity was conducted by a team of scientists from the University of California in Los Angeles (UCLA), USA, All India Institute of Medical Sciences, India (AIIMS), and National Marrow Donor Program (NMDP), USA.
More immunity in Indian genes The title of Nature Asia magazine article.
Our bodies have one of the toughest immune systems in the world. We have grown up surrounded by so much filth and pollution that our natural resilience is much stronger than people in the developed world. Sandipan Deb in Livemint.
False.
1. The Livemint article is based on a superficial understanding of the title of the Nature Asia, not its text.
The Nature Asia article is titled More immunity genes in Indians. However, the article itself does not make any such claims that, on the basis of the research study quoted, that Indians will be protected from the coronavirus pandemic or other infections due to their biologically inherited resilience. It simply states that Indians may have more genes linked with immunity as per the data. Also, one of the authors of the article and the research study Rajalingam Raja wrote, Whether having more activating KIR genes is an advantage or disadvantage for Indians remains to be elucidated.
This means that the genes tested through this study are not a piece of conclusive evidence that the contested tougher immunity will be an advantage for Indians in any way.
2. The Nature Asia article is based on a research study based on a single gene polymorphism in various ethnicities.
The Nature Asia article is based on a research study which relies upon a single gene KIR2DL5 polymorphism in many ethnicities including Indian, East Asian, white (Caucasian) and black (African Americans), suggesting that the gene is not unique to Indians only. Also, no evidence suggests that the presence of gene translates to gene expression or phenotypic change (e.g. higher immunity) in this case.
Nature Asia article based its claim on a gene polymorphism study by Du and colleagues (2008). Genetic polymorphism is the occurrence of multiple forms of a single gene which is expressed in the same population as a trait or a phenotype (Bull, 2004). It is similar, but not the same, as varying levels of pigmentation in eyes, hair or skin colour.
The study quoted showed the nature of polymorphism of one gene KIR2DL5 in four ethnic groups: Caucasians (European race, mostly white), Asian-Indians (South Asians), African-Americans and Asians (East Asians, i.e. Korean, Vietnamese, Japanese and Filipino).
KIR2DL5 (or CD158f) is the last identified KIR gene (the inhibitory receptor expressed on the surface of immune cells), with KIR2DL4, it makes up a structurally divergent lineage conserved in different primate species such as humans. The percentage frequency of this KIR2DL5 gene in Indians is used as an indicator of higher immunity.
The graph from the research study illustrates that the percentage frequency of KIR2DL5 (A and B, polymorphic forms of KIR2DL5 gene) is higher in Asian Indians than the other ethnic populations studied. However, the graph below from the same study suggests that the Individuals carrying the KIR2DL5 gene vary substantially among populations ranging in frequency from 35-85%. Thus, as per the authors conclusions, higher immunity can be found in every ethnicity ranging from 35-85% population, not just in Indians.
Hence, with such large variability in genes in each population, it is impossible to deduce that the researchers certainly found the KIR2DL5 gene more frequently in Indian ethnicities, as compared to other ethnicities.
Also, the research paper doesnt claim that this higher frequency in Asian-Indians population is linked to a better immune system or more natural killer cells in the body. In fact, there are no conclusions drawn on any ethnic group being genetically superior or inferior regarding immunity.
3. Is the occurrence of genes (KIR2DL5 gene) linked with immunity synonymous with its traits (tougher immunity)?
The occurrence of more genes in a population isnt always synonymous with better traits. This is mainly because a greater amount of genes doesnt always translate to a protein abundance, which consequently becomes a trait. That is, the presence of genes doesnt always lead to the presence of characteristic traits related to the expression of the gene.
Sometimes, polymorphic changes in natural killer cells can also be associated with a susceptibility towards certain diseases (Orange, 2002). Thus, more correlative studies should be conducted where a higher frequency of KIR2DL5 gene results in an increased immunity regardless of ethnicity.
4. Smaller sample size
The beneficial effects of higher frequency of a polymorphic gene in a population can only be established after detailed protein, genomics and evolutionary studies with large sample size. But in this study, only 96 Indian genomes were studied as opposed to 250 Caucasians. Hence, these higher percent frequencies of polymorphs KIR2DL5 gene could also be an artefact resulting from a smaller sample size.
Only 96 non-randomised samples for the Asian-Indian group were sourced from New Delhi, which is a minuscule representation for the Indian population. These sample sizes were further reduced after identification of KIR2DL5 positive individuals.
Also, the Nature Asia article further claims that Indians gained the activating KIR (killer cell immunoglobulin-like receptors) genes because of natural selection to survive the environmental challenges during their pre-historic coastal migrations from Africa. This conclusion is not based on any evidence.
Dr Mehra, former Dean of AIIMS, in his opinion piece in The Print mentions the results from the same study that includes SK Sharma of AIIMS, to make his claims about the genetic advantage of Indians over Caucasians with respect to immunity against the coronavirus. Additionally, Dr Mehra also included other factors that may give Indians advantage broad-based immunity due to overexposure to other pathogens, and epigenetic factors such as environment and consumption of Indian spices in cuisine. However, since the novelty of the virus and the increasing pathogenesis of SARS-CoV-2 in India, these claims remain without any research or evidence in Science.
The Nature Asia article published a misleading title on the basis of a genetics study which was termed inconclusive by the authors in their own research study. This title formed the basis of the Livemint article by Mr Deb.
The Nature Asia authors generalised their misleading article about Natural Killer cells (NK) to immunity genes. Natural killer cells are a small component of what makes up human immunity, not the expansive immune system.
Later, in the Livemint article, the Nature Asia article was used to claim a blanket superiority of the immune system of Indians. Mr Deb stated that Indians immune system is more robust than the people in the developed world to tackle the coronavirus pandemic.
Such dangerous opinion pieces with no understanding of the genetics of immunity have the potential to drive people to be careless with the protocols issued by the government on social distancing and other precautions or to encourage reckless behaviour during a critical situation.
Du, Z., Sharma, S. K., Spellman, S., Reed, E. F., & Rajalingam, R. (2008). KIR2DL5 alleles mark certain combination of activating KIR genes. Genes & Immunity, 9(5), 470-480.
Bull, L. (2004). Genetics, Mutations, and Polymorphisms. Molecular Pathogenesis of Cholestasis, 77-95.
Estefana, E., Flores, R., Gmez-Lozano, N., Aguilar, H., Lpez-Botet, M., & Vilches, C. (2007). Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. The Journal of Immunology, 178(7), 4402-4410.
Orange, J. S. (2002). Human natural killer cell deficiencies and susceptibility to infection. Microbes and infection, 4(15), 1545-1558.
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With Sports on Hold, Restless Gamblers Turn to Videogames – WIRED
Posted: at 3:47 pm
If theres one word to describe hardcore sports fanatics right now, its desperation. With coronavirus-related season suspensions hitting the NBA, NCAA, MLB, NHL, and more, habitual sports-watchers are turning to marble racing, binge-watching Netflix, and asking sportscaster Joe Buck to narrate their sex tapes. (Unsuccessfully. He is, however, providing play-by-plays of peoples backyard chicken coops and dog-exercising.)
If its doom-and-gloom for sports, you can be certain the billion-dollar sports betting industry isnt faring much better. Log in to any of the dozens of sports betting websites with an Andrew Jackson burning a hole in your pocket and youll find your pants singed; theres barely anything live to bet on.
Its been a bloodbath, says Ebbe Groes, CEO of sports betting software company EveryMatrix. The betting volume for regular sports events dropped about 80 percent as there was nothing left to bet on. Thats when we turned to esports.
Over the past four years, online betting sites have been slowly welcoming fans of the volatile but growing industry of livestreamed competitive gaming into their pools and brackets. As two teams of pro gamers go head to head in a League of Legends match live on Twitch, risk-loving viewers tab onto websites like DraftKings, Betway, and Loot.bet hoping to earn a bit of cash from their savvy projections. Now, these sites are describing an exponential surge in betting spurred by the dearth of traditional sports contentdespite some of the risks involved with the Wild West esports industry.
In less than a month, the volume of dollars Groes has seen bet on esports has gone up by a factor of 10. EveryMatrix offers software facilitating esports betting on everything from Fortnite and FIFA to dozens of online betting sites, from Germanys Mybet to Russias 1xBet. Before Covid-19 hit, esports bets constituted just 1 percent of bets he saw. Now, its 35 percent. The typical bet, he says, remains $25 between sports and esports betters.
Especially now with this kind of downtime with sports, esports have stepped up and become the number one offering on DraftKings, says Matt Kalish, cofounder and president of DraftKings North America, which facilitates fantasy sports drafting. Esports fantasy contests are 20 times more popular than they were prior to the pandemic, he says.
For dedicated esports betting site Loot.bet, daily bet volume has grown by 20 percent. In 2019, live bets accounted for 75 percent of volume, but in March 2020 that had grown to 83 percent, says a Loot.bet representative. Were putting this down to the huge number of fans in lockdown, who are watching more live esports streams, and hence placing more live bets.
Seasoned sports betters looking for an easy onboarding into digital gaming are slowly finding their way onto sites that allow betting on sports sims. Fans of Nascar are betting on eNascar, a racing league built on the iRacing simulator. In March, a Pro Invitational Series cropped up; one night drew 1.6 million unique viewers, some of whom were keeping things spicy on betting sites. (DraftKings has a $10,000 winner-take-all Sportsbook Pools contest.) On March 31, 2K Gaming, the NBA, and the NBPA announced the NBA 2K Players Tournament, which will feature competitions between 16 top NBA players, including Kevin Durant and Trae Young. The champion will receive $100,000, to be donated to a charity combating Covid-19. Standard sports betting sites like Bovada are publishing odds.
Although sports sims have the sexiest sell to desperate fans seeking a familiar thrilla nearly one-to-one ratio of play to gameplaybetting sites say theyre seeing low betting volumes so far. However, Loot.bet says that over the past month, the volume of bets it has received on soccer sim FIFA 20 exceeded the combined total of bets placed on Starcraft 2, Call of Duty, and Overwatchgames that arent necessarily huge among esports betters but are popular to watch.
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With Sports on Hold, Restless Gamblers Turn to Videogames - WIRED
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5,000 workers furloughed as coronavirus busts casinos – The Times of Northwest Indiana
Posted: at 3:47 pm
It's a similar story at the Majestic Star casinos, owned by Indiana-based Spectacle Entertainment, which continued paying its employees through March 29, despite lacking the financial resources of its Region gaming competitors.
Spectacle also is paying 100% of the cost of employee health benefits through the end of April, according to a company announcement.
"Our team members are our most valuable asset and the champions of our business. Unfortunately, except for some security, surveillance and other critical personnel, we had no choice but to furlough approximately 95% of our workforce on March 30, in accordance with union and non-union guidelines," the company said.
"It is our sincere hope we can get through this critical situation and bring our team back together with as minimal hardship as possible."
Ameristar parent Penn National Gaming Inc. previously announced it had furloughed its employees March 31. Though the company is maintaining employee medical benefits until June 30.
Currently, the only Northwest Indiana casino still paying all of its employees is Michigan City's Blue Chip Casino, owned by Boyd Gaming.
Boyd announced March 27 it would continue employee pay and benefits until April 10. It has not said what will happen after Friday.
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5,000 workers furloughed as coronavirus busts casinos - The Times of Northwest Indiana
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Evotec Expands into Gene Therapy – Associated Press
Posted: April 6, 2020 at 5:06 pm
HAMBURG, GERMANY / ACCESSWIRE / April 6, 2020 / Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) today announced that the Company has established a dedicated site for research and development of gene therapy-based projects: Evotec Gene Therapy (Evotec GT) which will start operations with a strong team of gene therapy experts at an R&D site in Orth/Donau, Austria.
Evotec GT is an integral part of Evotecs integrated drug discovery platform and complements the Companys existing expertise. This strategic addition marks an important step towards Evotecs long-term vision of becoming a fully modality-agnostic drug discovery and development partnership company.
The team in Austria have worked together for many years and applied their research within gene therapy to different gene therapy-related technologies as well as various indications. The scientists have deep expertise in vectorology and virology as well as disease insights, in particular in hemophilia, hematology, metabolic and muscle diseases. Evotec GTs fully operational site will enable the Company to perform dedicated services in the field of gene therapy along the value chain of its customers from Pharma and biotech as well as foundations and academia.
Dr Werner Lanthaler, Chief Executive Officer of Evotec, commented: We are delighted to initiate our new gene therapy platform and step into this field, which perfectly fits into our business strategy going forward. In recent years, precision medicines based on cell and gene therapies have emerged and are predicted to grow significantly. Gene therapy is a promising approach in the development of genetic medicines for patients, especially for inherited and rare diseases. Finding the best candidate agnostic of modality for any given disease biology will ultimately bring forward the best medicine for patients.
Dr Friedrich Scheiflinger, EVP Head of Gene Therapy at Evotec, said: We are proud to join the growing Evotec team to add the highly promising modality of gene therapy to drug discovery projects. Our team has performed research in the field across different technologies and therapeutic areas for many years and we look forward to leveraging our expertise as part of the truly impressive, modality-agnostic Evotec platform.
About Gene Therapy
Gene therapy is a technique that modifies a persons genes to treat or prevent disease by introduction, removal or editing of genetic material, specifically DNA or RNA, within the cells of a patient. Gene therapies aim to replace a disease-causing gene with a healthy copy, inactivate a disease-causing gene, introduce a new or modified gene or interfere on an expression-regulatory level to support treatment of a disease. Through this modification of gene expression, gene therapies can increase levels of disease-fighting proteins or reduce levels of disease-causing proteins within the cell. Since direct insertion of genes into cells is still very inefficient, gene delivery is facilitated by vehicles which are most often of viral origin. The structure of these viral vectors has been modified to accommodate for the therapeutic gene and to render the vector non-infectious. Depending on the indication and the affected tissue, the technique can be either applied ex-vivo or in-vivo, i.e. with or without removing the cells from the patients body for the therapeutic procedure.
According to various analyst reports, the gene therapy market was valued at approx. $ 500 m in 2018 and the market is expected to reach > $ 5 bn by 2025 with an impressive CAGR of ~34% over the forecast period. Furthermore, rapid and significant progress in the molecular and cellular biology arena, driven by technological advancements in genomics and gene-editing tools, has contributed to an increasing number of approved gene therapies as well as an expanding pipeline. According to the Alliance for Regenerative Medicine (ARM), by the end of the second quarter of 2019, there were more than 700 clinical trials ongoing globally.[1]
ABOUT EVOTEC SE Evotec is a drug discovery alliance and development partnership company focused on rapidly progressing innovative product approaches with leading pharmaceutical and biotechnology companies, academics, patient advocacy groups and venture capitalists. We operate worldwide and our more than 3,000 employees provide the highest quality stand-alone and integrated drug discovery and development solutions. We cover all activities from target-to-clinic to meet the industrys need for innovation and efficiency in drug discovery and development (EVT Execute). The Company has established a unique position by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuronal diseases, diabetes and complications of diabetes, pain and inflammation, oncology, infectious diseases, respiratory diseases, fibrosis, rare diseases and womens health. On this basis, Evotec has built a broad and deep pipeline of approx. 100 co-owned product opportunities at clinical, pre-clinical and discovery stages (EVT Innovate). Evotec has established multiple long-term alliances with partners including Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, CHDI, Novartis, Novo Nordisk, Pfizer, Sanofi, Takeda, UCB and others. For additional information please go to http://www.evotec.com and follow us on Twitter @Evotec.
FORWARD LOOKING STATEMENTS Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.
Contact Evotec SE:
Gabriele Hansen, SVP Corporate Communications, Marketing & Investor Relations, Phone: +49.(0)40.56081-255,
[1] Sources: https://www.grandviewresearch.com/industry-analysis/gene-therapy-market; https://www.marketwatch.com/press-release/at-339-cagr-gene-therapy-market-size-to-surpass-usd-518-billion-by-2025-2019-09-16; https://www.prnewswire.com/news-releases/gene-therapy-market-to-garner-6-21-bn-globally-by-2026-at-34-8-cagr-says-allied-market-research-300975194.html
SOURCE: Evotec AG via EQS Newswire
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Siddhartha Mukherjee and Ken Burns Present PBS Premiere of ‘The Gene: An Intimate History’ – Columbia University
Posted: at 5:06 pm
Q. You and Burns have worked together in the past. Could you describe the collaborative process of turning a book into a documentary?
A. First of all, its an incredible collaboration. When Ken and I launch a film we begin with talks about the book, both of us excited and aware that we are wading into the unknown. We take long walks through Central Park and ask questions outside the nitty gritty of the film: What is the mood of the film? What are the primary messages were trying to convey? I was lucky to work on The Gene with largely the same production team that adapted my first book, The Emperor of All Maladies: A Biography of Cancer, including the incredible filmmaker Barak Goodman (JRN86).
A film is different from a book. In The Gene we wereable to include a trove of historical footage and humanize the inspiring stories of patients and their families seeking cures for their genetic disease. People like Nancy Wexler, professor of neuropsychology at Columbias medical center, who has spent most of her life on an odyssey to find the gene for Huntingtons, a disease that killed her mother. Luke Rosen and Sally Jackson, parents on a tireless quest to raise awareness for their daughters rare degenerative disease. These personal stories help genetics come to life, but they also highlight how much we still do not know. I hope people will find the mood of our film somber, thoughtful and hopeful.
Q. For $200 a person can order a profile of his or her genome that provides ancestral information, as well as genetic health risks. Do you see this as a positive societal development?
A. The question you have to ask is do we want to live in a world where you can send a sample of saliva and find out that you have a 10 percent or 20 percent risk of developing breast cancer in the next 30 years. This information can be useful, motivating you to adopt more positive health behaviors. But it also marks you, changes you. It can change your relationship with yourself, your body. When you decide to test for future risk you are also, inevitably, asking yourself, what kind of future am I willing to risk?
Q. Could genetics play a role in how vulnerable a person is to contracting COVID-19, and whether that person is more at risk of dying from the illness?
A. This is one of the great mysteries of this infection. Young, healthy people are dying, even if most serious cases occur in the elderly and those with pre-existing conditions. There are multiple studies trying to unravel why some people infected with SARS-Cov2, the virus that causes COVID-19, fall seriously ill, while others show only mild or nonexistent symptoms.We are finding a correlation between high viral loadthe amount ofvirus present in any sample taken from a patientand more severe illness.
As I argued recently in The New Yorker, we have done a good job measuring the spread of the virus across populations, but it is now time we learn more about how SARS-Cov2 behaves in the body. This requires large-scale efforts to collect the DNA of people and the virus that they are infected with. One example of a study might be taking the DNA of those with serious underlying disease and comparing it to the DNA of those with mild or asymptomatic cases. We need to determine whether genetic variations among humans affect how susceptible individuals are to COVID-19 infections as rapidly as possible.
Q. What would you like audiences will take away from the film?
A. We hope The Gene will help people understand that the story of the revolution in genetics that is transforming medical science is also the story of what makes us who we are. Wed like to see the film spark a national conversation. The National Institute of Healths National Human Genome Research Institute, our outreach and education partner, is planning many activities. We are in conversations with people in cities across the country, including policymakers and science educators, right down to the primary school level, to take part in discussions and host screenings.
In the next few weeks NIH will launch an interactive digital platform that will go beyond the book and film, adding discussion of the COVID-19 pandemic. After you watch the film, please keep up with us on Twitter to learn more about these activities. Visit @DrSidMukherjee, @KenBurns and @WETA (our producing public media station). Stay tuned.
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Siddhartha Mukherjee and Ken Burns Present PBS Premiere of 'The Gene: An Intimate History' - Columbia University
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How ‘viral load’ and genetics could explain why young people have died from coronavirus – The Independent
Posted: at 5:06 pm
The coronavirus pandemic has hit older people far harder than those who are younger, but scientists are yet to fully understand why this is.
Many of the elderly people who have died have had pre-existing health conditions such as heart disease, lung disease and diabetes, all of which make fighting the virus more difficult, but many have not had any such health problems, and occasionally the virus has caused the deaths of younger, apparently healthy people.
Researchers around the world are racing to learn how the virus behaves, which health factors put people most at risk, and are trying to work out whether there may be genetic traits that could mean some people respond to the infection differently to others.
Sharing the full story, not just the headlines
There are various theories to suggest why the virus is so unusually and devastatingly selective.
Some scientists have suggested the greater the amount of virus that infects an individual known as the viral load could make a large difference to how the body is able to respond to infection.
Put simply,the larger the dose of the virus a person gets, the worse the infection is, and the least promising the outcome.
A parallel school of thought is that genetic variations between humans differences in our DNA could affect how susceptible an individual is to the virus.
And another candidate for why apparently healthy young people are dying is they may have a highly reactive immune system, which is sent into overdrive fighting off the virus. In such a scenario, a huge inflammation storm could inadvertently overwhelm vital organs such as the lungs.
None of the theories compete with one another, and aspects of all of them, as well as innumerable other factors, could be at play in an individual case.
Viral load
No hype, just the advice and analysis you need
Dr Edward Parker of the London School of Hygiene and Tropical Medicine, explained how a high viral load can impact humans. He said: After we are infected with a virus, it replicates in our bodys cells. The total amount of virus a person has inside them is referred to as their viral load. For Covid-19, early reports from China suggest the viral load is higher in patients with more severe disease, which is also the case for Sars and influenza.
The amount of virus we are exposed to at the start of an infection is referred to as the infectious dose. For influenza, we know that that initial exposure to more virus or a higher infectious dose appears to increase the chance of infection and illness. Studies in mice have also shown that repeated exposure to low doses may be just as infectious as a single high dose.
He added: So all in all, it is crucial for us to limit all possible exposures to Covid-19, whether these are to highly symptomatic individuals coughing up large quantities of virus or to asymptomatic individuals shedding small quantities. And if we are feeling unwell, we need to observe strict self-isolation measures to limit our chance of infecting others.
Professor Wendy Barclay, the head of the Department of Infectious Disease at Imperial College London, said existing knowledge of viral load means healthcare workers can be at greater risk of infection.
In general with respiratory viruses, the outcome of infection whether you get severely ill or only get a mild cold can sometimes be determined by how much virus actually got into your body and started the infection off. Its all about the size of the armies on each side of the battle, a very large virus army is difficult for our immune systems army to fight off.
So standing further away from someone when they breathe or cough out virus likely means fewer virus particles reach you and then you get infected with a lower dose and get less ill. Doctors who have to get very close to patients to take samples from them or to intubate them are at higher risk so need to wear masks.
Genetic differences between those infected
Scientists are currently preparing to scour Covid-19 patients genomes for DNA variations that might indicate why some people are more at risk than others.
The findings could then be used to identify groups most at risk of serious illness and those who might be protected, and this knowledge could then inform the hunt for effective treatments.
A huge effort to pool DNA research from patients around the world is now on, with the ultimate goal being to build a body of evidence from people with no underlying health issues, but who have reacted differently to infection by the virus.
One promising strand of research into why some people are more susceptible to the coronavirus is on the gene variation for the cell surface protein angiotensin-converting enzyme 2 (ACE2), found on the outer membranes of cells, and which the coronavirus uses to enter cells in the lungs and airways.
Variations in production of ACE2 could make it easier or more difficult for the virus to enter and infect cells.
We see huge differences in clinical outcomes and across countries. How much of that is explained by genetic susceptibility is a very open question, geneticist Andrea Ganna, of the University of Helsinkis Institute for Molecular Medicine Finland, told Science Magazine.
Another fascinating line of inquiry is whether different blood types could lead to differing levels of susceptibility to the disease.
A Chinese research team reported in a non-peer-reviewed article that people with type O blood may be protected from the virus, and those with type A blood could be at greater risk.
Were trying to figure out if those findings are robust, Stanford University human geneticist Manuel Rivas told Science Magazine.
The first results from the investigations into genetic differences and susceptibility are expected in less than two months time.
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How 'viral load' and genetics could explain why young people have died from coronavirus - The Independent
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BioMarin Plans Regulatory Submissions for Marketing Authorization of Vosoritide to Treat Children with Achondroplasia in 3Q 2020 in both US and Europe…
Posted: at 5:06 pm
SAN RAFAEL, Calif., April 6, 2020 /PRNewswire/ --BioMarin Pharmaceutical Inc.(NASDAQ: BMRN) today announced that based on recent meetings with health authorities in the US and Europe, the Company plans to submit marketing applications to the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the third quarter of 2020 for vosoritide.Vosoritide is an investigational, once daily injection analog of C-type Natriuretic Peptide (CNP) for achondroplasia, the most common form of disproportionate short stature in humans.
The marketing applications are based on the outcomes from the randomized, double-blind, placebo-controlled Phase 3 study evaluating the efficacy and safety of vosoritide, announced in Dec 2019, and further supported by the long-term safety and efficacy from the Phase 2 study, ongoing extension studies, and extensive natural history data. If approved, vosoritide would be the first medicine for the treatment of Achondroplasia in the US and Europe.
"We have worked with the regulatory authorities throughout the design and development of our clinical program and look forward to the ongoing interactions in the evaluation of the safety and efficacy of vosoritide in children with achondroplasia," said Hank Fuchs, M.D., President Worldwide Research and Development at BioMarin."We believe that we have a strong data package that combines the gold standard of a randomized, double-blind, placebo-controlled Phase 3 study with the long-term results in the Phase 2 open label study and extensive contemporaneous natural history data to evaluate durability.We are grateful to the children and families who have participated in these studies and are contributing to the greater body of scientific data on a potential treatment for achondroplasia."
"Vosoritide is the first potential pharmacological treatment for the underlying cause of achondroplasia. It could be a medical breakthrough in providing physicians with a new tool to treat individuals with achondroplasia," said John A. Phillips, III, M.D., Vanderbilt University Medical Center (David T Karzon Professor of Pediatrics) and investigator for the vosoritide clinical program. "To have such a possible treatment for achondroplasia on the horizon, where none existed before is significant progress."
"We are making great strides in understanding the biology of skeletal dysplasia and getting closer to a potential treatment," said Klaus Mohnike, Professor of Paediatrics at Magdeburg University Hospital in Germany and investigator for the vosoritide clinical program. "I am looking forward to therapeutic interventions that go beyond treating symptoms and have the potential to make a lasting difference for those affected children."
Vosoritide has received orphan drug designation from the FDA and EMA for the treatment of achondroplasia.The Orphan Drug Designation program is intended to advance the evaluation and development of products that demonstrate promise for the diagnosis and/or treatment of rare diseases or conditions.
Description of Phase 3 Study
The global Phase 3 study was a randomized, double-blind, placebo-controlled study of vosoritide in 121 children with achondroplasia aged 5 to 14 for 52 weeks. (The enrollment age criteria were 5 to 18 per the study protocol).Vosoritide is being tested in children whose growth plates are still open. This is approximately 25% of people with achondroplasia. Children in this study have completed a minimum six-month baseline study to determine their baseline growth velocity prior to entering the Phase 3 study.The primary endpoint of the study was the change in growth velocity from baseline over one year in children treated with vosoritide compared to placebo. A wide range of secondary and exploratory endpoints included anthropometric measures such as height Z-score, body and limb proportionality and joint geometry; biochemical, biomarker and radiological assessments of bone growth and health; and evaluations of health-related quality of life (HRQoL), developmental status, and functional independence.These additional endpoints address the overall impact vosoritide has on achondroplasia and continue to be evaluated in an ongoing open-label extension study where all subjects receive active treatment.
Description of Phase 2 Dose Finding Study
The primary objectives of the open-label, sequential cohort, dose-finding study were to evaluate the safety and tolerability of daily subcutaneous vosoritide and to determine the dose to carry forward to Phase 3. Secondary objectives were to evaluate the effects of vosoritide on change from pre-treatment baseline in annualized growth velocity (cm/year), height Z-scores, and body segment proportionality, the vosoritide pharmacokinetic (PK) profile, and biomarkers of vosoritide activity, and endochondral ossification. All children who completed the 24-month dose finding study were then eligible to continue long term follow up in the ongoing extension study which provides long term evidence of efficacy, durability of effect and safety.
About Achondroplasia
Achondroplasia, the most common form of disproportionate short stature in humans, is characterized by slowing of endochondral ossification, which results in disproportionate short stature and disordered architecture in the long bones, spine, face and base of the skull.This condition is caused by a mutation in the fibroblast growth factor receptor 3 gene (FGFR3), a negative regulator of bone growth. Beyond disproportionate short stature, people with achondroplasia can experience serious health complications, including foramen magnum compression, sleep apnea, bowed legs, mid-face hypoplasia, permanent sway of the lower back, spinal stenosis and recurrent ear infections. Some of these complications can result in the need for invasive surgeries such as spinal cord decompression and straightening of bowed legs. In addition, studies show increased mortality at every age.
More than 80% of children with achondroplasia have parents of average stature and have the condition as the result of a spontaneous gene mutation.The worldwide incidence rate of achondroplasia is about one in 25,000 live births.Vosoritide is being tested in children whose growth plates are still "open," typically those under 18 years of age.This is approximately 25% of people with achondroplasia.In the U.S., Europe, Latin America,the Middle East, and most of Asia Pacific, there are currently no licensed medicines for achondroplasia.
About BioMarin
BioMarin is a global biotechnology company that develops and commercializes innovative therapies for patients with serious and life-threatening rare genetic diseases. The company's portfolio consists of six commercialized products and multiple clinical and pre-clinical product candidates. For additional information, please visit http://www.biomarin.com. Information on such website is not incorporated by reference into this press release.
Forward-Looking Statement
This press release contains forward-looking statements about the business prospects of BioMarin Pharmaceutical Inc. (BioMarin), including, without limitation, statements about: BioMarin's vosoritide development program generally and specifically about the Company's planned submissions for marketing applications in the U.S. to the FDA and in Europe to the EMA, the strength of the data package to be submitted to regulatory authorities, the continued clinical development of vosoritide and the timing and conduct of such clinical program; the possible results of such studies, and the timing of the submissions of marketing applications to health authorities in the U.S. and Europe. These forward-looking statements are predictions and involve risks and uncertainties such that actual results may differ materially from these statements. These risks and uncertainties include, among others: final analysis of the Phase 3 data, results and timing of current and planned preclinical studies and clinical trials of vosoritide; our ability to successfully manufacture vosoritide; the content and timing of decisions by the U.S. Food and Drug Administration, the European Commission and other regulatory authorities concerning vosoritide; and those other risks and uncertainties detailed from time to time under the caption "Risk Factors" and elsewhere in the BioMarin's Securities and Exchange Commission (SEC) filings, including, without limitation, BioMarin's Quarterly Report on Form 10-K for the year ended December 31, 2019, and future SEC filings and reports by BioMarin. BioMarin undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events or changes in its expectations.
BioMarin is a registered trademark of BioMarin Pharmaceutical Inc.
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BioMarin Pharmaceutical Inc.
BioMarin Pharmaceutical Inc.
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BioMarin Plans Regulatory Submissions for Marketing Authorization of Vosoritide to Treat Children with Achondroplasia in 3Q 2020 in both US and Europe...
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What The Coronavirus Does To Your Body That Makes It So Deadly – IFLScience
Posted: at 5:06 pm
COVID-19 is caused by a coronavirus called SARS-CoV-2. Coronaviruses belong to a group of viruses that infect animals, from peacocks to whales. Theyre named for the bulb-tipped spikes that project from the viruss surface and give the appearance of a corona surrounding it.
A coronavirus infection usually plays out one of two ways: as an infection in the lungs that includes some cases of what people would call the common cold, or as an infection in the gut that causes diarrhea. COVID-19 starts out in the lungs like the common cold coronaviruses, but then causes havoc with the immune system that can lead to long-term lung damage or death.
SARS-CoV-2 is genetically very similar to other human respiratory coronaviruses, including SARS-CoV and MERS-CoV. However, the subtle genetic differences translate to significant differences in how readily a coronavirus infects people and how it makes them sick.
SARS-CoV-2 has all the same genetic equipment as the original SARS-CoV, which caused a global outbreak in 2003, but with around 6,000 mutations sprinkled around in the usual places where coronaviruses change. Think whole milk versus skim milk.
Compared to other human coronaviruses like MERS-CoV, which emerged in the Middle East in 2012, the new virus has customized versions of the same general equipment for invading cells and copying itself. However, SARS-CoV-2 has a totally different set of genes called accessories, which give this new virus a little advantage in specific situations. For example, MERS has a particular protein that shuts down a cells ability to sound the alarm about a viral intruder. SARS-CoV-2 has an unrelated gene with an as-yet unknown function in that position in its genome. Think cow milk versus almond milk.
How the virus infects
Every coronavirus infection starts with a virus particle, a spherical shell that protects a single long string of genetic material and inserts it into a human cell. The genetic material instructs the cell to make around 30 different parts of the virus, allowing the virus to reproduce. The cells that SARS-CoV-2 prefers to infect have a protein called ACE2 on the outside that is important for regulating blood pressure.
The infection begins when the long spike proteins that protrude from the virus particle latch on to the cells ACE2 protein. From that point, the spike transforms, unfolding and refolding itself using coiled spring-like parts that start out buried at the core of the spike. The reconfigured spike hooks into the cell and crashes the virus particle and cell together. This forms a channel where the string of viral genetic material can snake its way into the unsuspecting cell.
SARS-CoV-2 spreads from person to person by close contact. The Shincheonji Church outbreak in South Korea in February provides a good demonstration of how and how quickly SARS-CoV-2 spreads. It seems one or two people with the virus sat face to face very close to uninfected people for several minutes at a time in a crowded room. Within two weeks, several thousand people in the country were infected, and more than half of the infections at that point were attributable to the church. The outbreak got to a fast start because public health authorities were unaware of the potential outbreak and were not testing widely at that stage. Since then, authorities have worked hard and the number of new cases in South Korea has been falling steadily.
How the virus makes people sick
SARS-CoV-2 grows in type II lung cells, which secrete a soap-like substance that helps air slip deep into the lungs, and in cells lining the throat. As with SARS, most of the damage in COVID-19, the illness caused by the new coronavirus, is caused by the immune system carrying out a scorched earth defense to stop the virus from spreading. Millions of cells from the immune system invade the infected lung tissue and cause massive amounts of damage in the process of cleaning out the virus and any infected cells.
Each COVID-19 lesion ranges from the size of a grape to the size of a grapefruit. The challenge for health care workers treating patients is to support the body and keep the blood oxygenated while the lung is repairing itself.
How SARS-CoV-2 infects, sickens and kills people.
SARS-CoV-2 has a sliding scale of severity. Patients under age 10 seem to clear the virus easily, most people under 40 seem to bounce back quickly, but older people suffer from increasingly severe COVID-19. The ACE2 protein that SARS-CoV-2 uses as a door to enter cells is also important for regulating blood pressure, and it does not do its job when the virus gets there first. This is one reason COVID-19 is more severe in people with high blood pressure.SARS-CoV-2 is more severe than seasonal influenza in part because it has many more ways to stop cells from calling out to the immune system for help. For example, one way that cells try to respond to infection is by making interferon, the alarm signaling protein. SARS-CoV-2 blocks this by a combination of camouflage, snipping off protein markers from the cell that serve as distress beacons and finally shredding any anti-viral instructions that the cell makes before they can be used. As a result, COVID-19 can fester for a month, causing a little damage each day, while most people get over a case of the flu in less than a week.
At present, the transmission rate of SARS-CoV-2 is a little higher than that of the pandemic 2009 H1N1 influenza virus, but SARS-CoV-2 is at least 10 times as deadly. From the data that is available now, COVID-19 seems a lot like severe acute respiratory syndrome (SARS), though its less likely than SARS to be severe.
What isnt known
There are still many mysteries about this virus and coronaviruses in general the nuances of how they cause disease, the way they interact with proteins inside the cell, the structure of the proteins that form new viruses and how some of the basic virus-copying machinery works.
Another unknown is how COVID-19 will respond to changes in the seasons. The flu tends to follow cold weather, both in the northern and southern hemispheres. Some other human coronaviruses spread at a low level year-round, but then seem to peak in the spring. But nobody really knows for sure why these viruses vary with the seasons.
What is amazing so far in this outbreak is all the good science that has come out so quickly. The research community learned about structures of the virus spike protein and the ACE2 protein with part of the spike protein attached just a little over a month after the genetic sequence became available. I spent my first 20 or so years working on coronaviruses without the benefit of either. This bodes well for better understanding, preventing and treating COVID-19.
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Benjamin Neuman, Professor of Biology, Texas A&M University-Texarkana
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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What The Coronavirus Does To Your Body That Makes It So Deadly - IFLScience
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Comforting a Loved One | Doctor’s Diary with Dr. Gene Dorio – SCVNEWS.com
Posted: at 5:05 pm
Hospitals do not have enough PPEs (personal protective equipment gloves, masks, gowns, shoe coverings), nor sufficient access to COVID-19 testing.
When a policy is made to disallow family members from being with loved ones, it is considered inhumane. Yet, hospitals must protect patients from spreading this virus to the medical staff and the public. One contaminating source could be from visiting family members.
Conversely, ill loved ones need a hand to hold and psychological support to alleviate pain and suffering. We know there are aspects of the mind that modern medicine cannot heal.
The initial solution: Utilize cell phone technology to maintain communication if your hospitalized loved one is capable.
The next solution: Find a way quickly to increase hospital PPE supplies and augment COVID-19 testing.
Once this is done:
Allow at least one garbed family member to be with their loved one;
Educate them on the proper use of PPEs;
Emphasize cleansing techniques like handwashing and keeping the surrounding room sterile;
Get testing for family members as well as staff.
Everyone must be protected and comforted, but lets adapt and find creative solutions to assure continued humanity in hospitals during this crisis.
Gene Uzawa Dorio, M.D., is a geriatric house-call physician who serves as president of the Los Angeles County Commission for Older Adults and Assemblyman to the California Senior Legislature. He has practiced in the Santa Clarita Valley for 32 years.
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Comforting a Loved One | Doctor's Diary with Dr. Gene Dorio - SCVNEWS.com
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Turning the Tide Lifestyle Medicine and Breast Cancer (Part 6) – South Coast Herald
Posted: at 5:05 pm
Dr David Glass - MBChB, FCOG (SA)
Today we celebrate our 100th blog on the subject of lifestyle medicine making wise choices in the area of diet, exercise, rest, sunlight, fresh air, water, relationships and spiritual connection. This is one area of medicine that seems to permeate all others. It is becoming increasingly important as diseases of poor lifestyle choices affect more and more people around the world resulting in rising incidences of heart disease, high blood pressure, diabetes, obesity, auto-immune diseases, cancer and dementia.
ALSO READ : Turning the Tide Lifestyle Medicine and Covid 19
Of course our minds are daily preoccupied with Covid-19, and so should they be. We are facing one of the most devastating challenges to health care and the economy the world has seen this century. Two weeks ago I presented a lifestyle approach to this pandemic, because we know that the virus is particularly aggressive in people who suffer chronic lifestyle diseases.
Today we will get back to our topic for this series breast cancer. Unfortunately Covid-19 doesnt make all the other diseases, to which we are so prone, go away. As mentioned before, this series is based on Dr Kristi Funks book Breasts: The owners manual. This week we will be looking at uncontrollable risk factors.
Next week we will briefly look at some of the interventions on offer in terms of treatment and screening to complete the series on breast cancer.
Stay safe, isolated as much as possible in your home. May you use this time for building family relationships and getting life priorities right. It is good to have some forced time for reflection when we are faced with the prospect of our own mortality or that of our friends and family.
Dave Glass
Dr David Glass MBChB, FCOG (SA)
Dr David Glass graduated from UCT in 1975. He spent the next 12 years working at a mission hospital in Lesotho, where much of his work involved health education and interventions to improve health, aside from the normal busy clinical work of an under-resourced mission hospital.
He returned to UCT in 1990 to specialise in obstetrics/gynaecology and then moved to the South Coast where he had the privilege of, amongst other things, ushering 7000 babies into the world. He no longer delivers babies but is still very clinically active in gynaecology.
An old passion, preventive health care, has now replaced the obstetrics side of his work. He is eager to share insights he has gathered over the years on how to prevent and reverse so many of the modern scourges of lifestyle obesity, diabetes, ischaemic heart disease, high blood pressure, arthritis, common cancers, etc.
He is a family man, with a supportive wife, and two grown children, and four beautiful grandchildren. His hobbies include walking, cycling, vegetable gardening, bird-watching, travelling and writing. He is active in community health outreach and deeply involved in church activities. He enjoys teaching and sharing information.
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Turning the Tide Lifestyle Medicine and Breast Cancer (Part 6) - South Coast Herald
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