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Category Archives: Transhuman News
Will the Pandemic Keep Third Parties Off the 2020 Ballot? – Jimmys Post
Posted: April 24, 2020 at 3:06 pm
To get on the ballot in the remaining states, they need to collect and submit petition signatures. And in a normal year, they would be on track to do just that. But because of the deadly coronavirusand the social-distancing and stay-at-home orders to minimize its spreadafter March 6, petitioning was over in the United States, as Libertarian Party executive director Daniel Fishman told me.
For Americas third parties, this is nothing less than an existential crisis. Without ballot access, national pollsters wont feel obligated to include Green and Libertarian candidates in their surveys; voters will be less aware of their nominees and platforms; journalists will be less likely to pay any attention to them; and the probability diminishes that either the Libertarians or Greens can reach the holy grail of five percent of the popular votethe point at which they would finally qualify for federal campaign matching funds.
But for the Democratic and Republican Parties, the absence of third parties from the ballot in key states makes 2020 genuinely unlike any presidential election in recent memoryminimizing the chances for spoiler candidates, while giving both major parties something they did not have in 2016: a two-person presidential race, and a simpler path to victory.
Now, dont count the Libertarians and Greens out just yet. There are multiple fronts to the fight ahead, as they see it, and theyre prepared for battle on each one.
What the Libertarians and Greens want most is for states to waive all remaining petition signature requirements. On March 30, Vermont did just that, via emergency legislation signed by the governor. (The Libertarian Party was already on the ballot in Vermont beforehand, but it added a state to the Green Party list.) Ballot Access News reports that [i]t is believed that Connecticut Governor Ned Lamont will soon issue an order that says political parties that are ballot-qualified for at least one statewide office will be deemed to be ballot-qualified for all partisan federal and state office, for 2020, (though both the Libertarians and Greens have already qualified for the presidential election there). A few states have taken smaller steps, such as allowing for electronic signature gathering and delaying deadlines, and more states may follow.
The Green Party is in the process of asking its members to press their governors to issue executive orders that follow Vermonts lead. But Brendan Phillips, the Green Partys ballot access coordinator, is not optimistic that the governors will be accommodating. I dont expect the majority of governors to provide us with any sort of relief, Phillips told me, because in the past, theyve actively fought to keep us off of the ballot. Asked if Republican governors might be eager to help the Greens out, he responded, I suppose that is possible they might want to open that door for us, but that might also open the door to other parties to do the same that they might not want on the ballot.
One party that Republicans might want to keep off the ballot is the socially conservative, anti-internationalist Constitution Party. Richard Winger, the editor of Ballot Access News and a highly regarded expert on third parties, told me the Constitution Party is likely to nominate a presidential candidate, Don Blankenship, who has wealth. That will make it easier for the party to fund the sort of operation necessary in order to get petition signatures and scoop up votes.
You may remember Blankenship from the 2018 campaign, when he ran for the Senate in West Virginia, first in the Republican primary, then in the general election on behalf of the Constitution Party. A coal baron who vehemently maintains his innocence after serving prison time on charges related to the fatal Upper Big Branch Mine disaster, Blankenship made waves for his low-budget ads that referred to Cocaine Mitch McConnell and trafficked in racism by referring to McConnells Asian-American in-laws as his China family.
Such offensive behavior didnt make Blankenship a senator, but in a presidential campaign, it could have more appeal to disaffected Trump voters than any nominee from the socially liberal, pro-immigration Libertarian Party. (In fact, Blankenship once called himself Trumpier than Trump.) By May 2, the final day of the Constitution Partys telephone-based national convention, well know if Blankenship officially receives the groups nomination. (Blankenships campaign did not respond to an email query from me.)
As of now, the Constitution Party isnt on the ballot in those swing states with Republican governors that the Greens want to access: Arizona, Georgia, Iowa and New Hampshire. So if those states GOP governors ease the Green Partys path to appearing on the ballot, it may also help out the Constitution Partypotentially to Trumps detriment.
Since the third parties are not expecting uniform assistance from state executive and legislative branches, they are gearing up for more court battles. Were prepared to sue everywhere that we have to, said Fishman, adding that he feels very confident that were going to win all of those court cases since theres never been a stronger case that the petition requirement is unreasonable.
Experts in election law who were consulted for this story were more skeptical.
Those kind of cases are not slam dunks because courts are generally wary of changing election rules, said Rick Hasen of UC-Irvine School of Law, citing litigation over this months primary election in Wisconsin, which culminated in the U.S. Supreme Court deciding that the state could not extend the deadline for mail-in ballots because preexisting state law implied they needed to be postmarked by Election Day. The Court majority was not very moved by arguments about Covid-19 being a compelling enough reason to change from the ordinary requirements of an election, said Hasen.
I would be shocked if the minor parties do as well in terms of ballot access this year as they did [in 2016], said Michael S. Kang of Northwestern Universitys Pritzker School of Law. He argues because of a lack of binding precedents, judges have a lot of discretion. In turn, he expects a mixed response with some states providing relief and others refusing to change the rules.
I think theyre going to win lawsuits, said Winger of Ballot Access News. He pointed to a Supreme Court precedent from the 1980 presidential election which augurs well for third party relief. In April of that year, Congressman John D. Anderson abandoned his Republican presidential primary bid for an independent campaign. But Ohios filing deadline for the general election was in March. Anderson got on the Ohio ballot thanks to a district court ruling (he also got on the ballot in every other state), and in Anderson v. Celebrezze, the Supreme Court concluded that excessively early filing deadlines violate the First Amendment.
Even so, Greg Magarian a law professor at Washington University in St. Louis, notes there is a competing precedent1994s Timmons v. Twin Cities Area New Partywhich, in his words, says that states can impose constraints on minor parties in order to promote political stability. That isnt quite a blank check, but its a strong declaration that states have a lot of latitude to restrict minor parties.
Meanwhile, the first court battle to waive all signature requirements is now being waged by the Libertarians and Greens in Illinois, with a hearing scheduled for April 17. The two parties have also teamed up for a Georgia lawsuit, asking the state to pro-rate the number of signatures required, accounting for the days during which canvassing is no longer possible. (Unlike the Greens, the Libertarian Party already met the Georgia requirements for its presidential nominee, but are hoping to aid a Libertarian U.S. House candidate.)
Another possible legal obstacle looms for Libertarians in states with relatively early filing deadlines that require the name of the presidential candidate to be specified. The Libertarian convention is scheduled for May 21 in Austin, Texas, but a delay is expected and alternative plans are not set. This poses a particular problem for the party in New Hampshire, which requires candidates from parties that have not prequalified for the November ballot to issue a statement of intent by June 12.
Other states allow third parties to submit names to serve as stand-ins until an official nominee is selected. But Washington State, Wisconsin and Alabama could present deadline problems similar to New Hampshires, though their deadlines are in late July or August.
So even if the Libertarians pitch a perfect game in the courts regarding the waiving of signature requirements, a delay in naming a nominee could still leave them short in a few states. And ballot access in all 50 states, plus DC, again is important to them.
That is the big issue, said Fishman, the executive director of the Libertarian Party. Lacking 50-state ballot access, you become the Green Party. The Green Party has never had 50-state ballot access, and thats why they still havent been taken seriously. It is not a trivial thing. It requires coordination at the party level that speaks to your competency, and in turn, the media tends to pick up on that. The Libertarian Party plans to sue to push back such deadlines if necessary.
The legal consequences of the pandemic are not the only potential obstacles facing the third and fourth biggest political parties. Neither party can be confident it will nominate candidates who can command as much attention as did their 2016 candidates.
Both parties ran the same candidates in the last two elections: former New Mexico Governor Gary Johnson for the Libertarians, Massachusetts physician-activist Jill Stein for the Greens. Broader ballot access, stronger resume, respectable running mate (fellow former governor William Weld) and a uniquely whimsical persona (described by comedian Samantha Bee as freaky-deaky) made Johnson the stronger vote-getter. But as Hillary Clinton ruefully recalled in her post-campaign memoir What Happened, in Pennsylvania, Michigan and Wisconsin, Stein won more votes than Trumps narrow margin of victory.
Johnson and Stein were helped in 2016 by having built-up name recognition in 2012, as well as by facing two major-party nominees with high unfavorability ratings. But since neither candidate wants to find out if the third times a charm, we will see new faces this year.
When the Green Party convenes in early July, most likely virtually, Howie Hawkins is expected to receive the nomination. Like Stein, Hawkins is a longtime party activist and past gubernatorial candidate, taking 1.7 percent of vote in 2018 against New Yorks Andrew Cuomo. But he has a long way to go before he is a household name.
The Libertarians have had a field of candidates largely unknown outside of party circles. Jacob Hornberger, an ally of Ron Paul, has won six of the nine nonbinding party primaries. (Perennial satirical candidate Vermin Supreme, who has taken on a slightly more serious tone this time around, has won two.) This past week, Jim Gray, a former California judge and Johnsons 2012 running mate, jumped in the race, defining himself to the libertarian Reason magazine as an incrementalist and a pragmatist. Gray had been supporting the Republican-turned-independent-turned-Democrat-turned-Libertarian Lincoln Chafee, but stepped in after Chafee suspended his campaign in early April.
Michigan Congressman Justin Amash, who attracted national attention for quitting the Republican Party and supporting Trumps impeachment, is attracting the most buzz. This past week, he teased a Libertarian presidential run and said he will make an announcement soon. Still, while he would be the highest office holder in the field, his nomination at the convention would not be assured. Johnson needed two ballots at the 2016 convention to win the nod, over opposition from the partys more radical faction that can be suspicious of former Republicans as insufficiently libertarian. (Johnson in 2016 described a Libertarian Party convention as composed of really wonderful, well-meaning, well-spoken people and then people that are just batshit crazy.)
And while his poll numbers could change if an announcement generated a lot of press coverage, Amash is not starting from a strong position; a Morning Consult poll this week pegs his support in a three-way race with Trump and Biden at a scant one percent. Such anemic numbers wouldnt help him convince party delegates that he possesses any special ability to help the party clear the 5 percent popular-vote threshold.
The popularity and notoriety of the actual nominees is not irrelevant to parties judicial strategy. Beyond the constitutional principles and legalities, judges may not feel much public pressure to bend over backwards for third-party candidates the public isnt clamoring to support.
Judges arent truly insulated from public sentiment about anything, said Magarian. If the public broadly wanted for minor parties to be able to compete more robustly in elections, I think courts would feel at least some background pressure to take minor parties complaints about ballot access seriously. Instead, my sense is that the public and most opinion leaders tend to view minor parties as troublemakers, spoilers and refuges for unserious political obstructionists.
Will the lack of ballot access for third parties impact the 2020 elections outcome?
Democrats have long blamed Green Party candidates for undermining their presidential candidates: in Florida and New Hampshire in 2000, and in Pennsylvania, Michigan and Wisconsin in 2016. In each of those state contests, the Green Party candidate won more votes than the Republican margin of victory. So for Democrats, the fewer swing states with third-party candidates on the ballot, the fewer heart palpitations.
But whether or not the third-party vote tipped the 2016 to Donald Trump is still hotly debated. Stein campaigned on the argument that Hillary Clinton was not progressive enough, but Johnson sought to attract votes from both disaffected Democrats and Republicans. Still, based on 2016 exit poll data, which asked respondents how they would vote in two-person race, Voxs Tara Golshan found that without Stein in the running, Clinton would have won Michigan, still lost Florida, and Wisconsin and Pennsylvania would have been a 48 to 48 percent toss-up. So, maybe it mattered, maybe it didnt.
At minimum, a robust minor-party presence complicates major-party strategizing. Instead of focusing on appeals to swing voters in the middle, confident that ones base is in place, major party candidates would have to worry about whether they need simultaneous appeals to swing voters on the fringes.
The battle for third-party legitimacy by the Libertarians and Greens in 2020 is not over. But if the nations state election officials, governors and judges dont swoop in to save them, Donald Trump and Joe Biden will able to face each other, one against one.
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Will the Pandemic Keep Third Parties Off the 2020 Ballot? - Jimmys Post
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Author Tours The ‘End Of The World,’ From Prairie Bunkers To Apocalypse Mansions – West Virginia Public Broadcasting
Posted: at 3:05 pm
While researching his new book, Notes from an Apocalypse, about people who are preparing for doomsday, author Mark O'Connell undertook what he calls "a series of perverse pilgrimages."
Some stops on O'Connell's "end of the world" journey include a prairie in South Dakota, where a former munitions facility is being converted into a "survival shelter community," and the New Zealand apocalypse house owned by PayPal founder Peter Thiel. He also attended a Los Angeles conference, where he met people who hope to colonize Mars and use it as a "backup planet" if Earth becomes inhospitable.
Though it was written before the COVID-19 pandemic, O'Connell says the research he conducted for the book is heavy with "dramatic irony" now.
"I bought a lot of practical guides to surviving the end of the world doomsday prepper guides and so on when I was writing the book," he says. "And I read them at the time in a spirit of scholarly interest."
But as the pandemic spread, he says, "I found myself taking one or two down off the shelf in that first week and sort of flicking through the index with something other than scholarly interest, I think it's fair to say."
Despite spending so much time steeped in end-of-days scenarios, O'Connell doesn't despair. In fact, the book is peppered with humor.
"Laughter is obviously a kind of a release valve," he says. "The funny stuff [in the book] comes as a result of a buildup of like an accumulation of anxiety and seriousness. I'm often up at my funniest as a writer when I'm dealing with the most serious things."
On the demographic profile of the doomsday preppers he spoke with
So the doomsday preppers who I look at in the first section of the book tended to be overwhelmingly male, and overwhelmingly white, and often conservative Christian. And the ideology that they bring to it is often one of, I would say, quite right-wing, quite libertarian, a mistrust of the state and a kind of a fetishization of ideas of kind of rugged self-reliance and masculinity. And often fantasies of defensive violence, ... an idea of: You have to protect your family, you have to protect your home. Often that involves guns and so on particularly in American context.
On visiting an apocalyptic real estate development in South Dakota
Part of the reason why I wanted to go there was that it just looked so otherworldly. It's a dairy farm, essentially in the prairies of South Dakota, which was used as a ... munitions facility. There's 500-something overground bunkers, reinforced concrete and steel kind of mounds coming out of the ground, covered in grass. And it just looks like something out of an alien landscape. So it's been bought by a ... guy named Robert Vicino. And he's bought the land and is selling off these bunkers for, I think, ... $35,000 is the figure that he quoted me. So the idea is that people buy these empty bunkers and convert them to their own sort of specifications. This is a place for people to retreat to in the event of certainly nuclear exchange ... [and] viral pandemics and any kind of situation that threatens civilizational collapse or civil unrest. The idea is that there would be ... a private army that would patrol the perimeter of this place to stop the war, to stop the rest of us getting in.
On why the Silicon Valley elite and other wealthy Americans are buying land in New Zealand
In a way, it didn't take you that long to figure out why New Zealand, because it is an insanely beautiful place, and if I had endless resources, I probably would want to buy a place in New Zealand. You could approach it as an apocalypse retreat or you could [approach it as] a nice holiday. ... New Zealand is a very politically stable place, a lot of clean air, an abundance of lakes, fresh water. It's far from everywhere else. So you don't have those kind of threats that you would have in Europe and America. It's quite distanced in various ways. So you can see the appeal. ...
To put it bluntly, I think a lot of New Zealand people, Mori in particular, see it as a kind of a return of the colonial mindset. So New Zealand as a country I think is unusual amongst kind of post-colonial nations of being absolutely open and absolutely resolute in having a strong but nuanced kind of understanding of what colonialism meant in the history of the country and how to sort of move beyond those mindsets. And I think there is a suspicion of people like [PayPal founder] Peter Thiel and wealthy Americans coming and buying up land that it might be a kind of a modern version of that sort of tragic colonial moment in the state's history.
On how some doomsday preppers see Mars as a backup planet
Mars is almost like the next step up from New Zealand. If New Zealand is kind of the safest retreat on this planet, then, if everything goes wrong here and the planet gets hit by an asteroid or whatever the term that is used amongst Mars enthusiasts would be we need a "backup planet." So we need a backup planet for humanity in case something goes catastrophically wrong with Earth. [Tesla CEO] Elon Musk is always using this term. Elon Musk would be, I suppose, the most prominent kind of advocate of Mars exploration, obviously, with his space exploration company SpaceX.
On why he visited Chernobyl for the book
I wanted to see what the end of the world looked like, in a way. And I also wanted to see what a catastrophic event on the order of Chernobyl what happens afterwards. I was fascinated by the ways in which life is kind of returning to this place in ways. Nature is thriving there. And not only nature, but people are living there. There's a relatively small number of people, in the dozens, generally older people who have returned there to live in their houses that they evacuated in the immediate aftermath of the disaster. ... But ultimately, what I was really interested in was catastrophe tourism. There are tour companies that have set up in and around Kiev who will bring you there and you can stay overnight, which is what I did on the tour. You get to explore Pripyat, which is the abandoned city that was purpose built for the workers and Chernobyl. It's a fascinating kind of insight into the sort of visual spectacle of the apocalypse. You get to wander around this kind of diorama of a sort of post-apocalyptic future. I think that's what attracts the people who are on this tour and to some extent myself.
Nature has reclaimed the place. Pripyat is full of nature just bursting forth out of concrete, and there is something sort of quietly beautiful about it. There's quite a large population of wolves there. So life is kind of going on without humanity. As bleak as it is, there's something slightly reassuring about that.
On whether he'd consider joining a doomsday community
If you're preparing for the collapse of civilization in that way, I think for you, civilization has already collapsed. - Mark O'Connell
Where I landed with it is that I would not want to be part of that community. I would not want to be part of a protected, sheltered, elite ... that was being protected by a private army. On some level, I think I'd rather be dead. I'd rather be outside and take my chances because it seems, from an ideological perspective, that is just too too bleak and too terrifying to me. ... If you're preparing for the collapse of civilization in that way, I think for you, civilization has already collapsed.
Sam Briger and Seth Kelley produced and edited the audio of this interview. Bridget Bentz, Molly Seavy-Nesper and Meghan Sullivan adapted it for the Web.
TERRY GROSS, HOST:
This is FRESH AIR. I'm Terry Gross. The coronavirus isn't the end of the world, but your anxiety may make you feel like it is. And your home may be feeling like a bunker. This makes my guest's new book, "Notes From An Apocalypse," strangely timely. It's about people who are preparing for a doomsday resulting from environmental catastrophe, nuclear war or a pandemic. The book is also about the reality of anxiety, like the anxiety you may be experiencing now.
Mark O'Connell is not preparing for the end of the world. But he is anxious about the future and what it holds for his two young children. And he's fascinated by people who've taken their doomsday and survival fantasies to extremes. As part of his research, he made a series of what he describes as perverse pilgrimages. He went to the prairies of South Dakota, where a former munitions facility is being converted into a, quote, "survival shelter community," and to New Zealand, where some Silicon Valley billionaires are planning on waiting out the collapse of civilization in a stable, remote retreat.
At a conference in LA, He met people who hoped to colonize Mars and use it as a backup planet for a doomed Earth. In Chernobyl, he saw what it looks like in a place where all life was eradicated. One of O'Connell's previous books, "To Be A Machine," is about transhumanism, the movement that believes new technologies implanted in human bodies will extend the cognitive and physical abilities of humans and extend life beyond our biological limitations. Mark O'Connell is speaking to us from his home in Dublin, Ireland. Mark O'Connell, welcome to FRESH AIR. How is the virus playing into your end-of-the-world anxieties?
MARK O'CONNELL: I guess, like everyone else, I've been on a bit of a trajectory with this thing for the last couple of months, for the last few weeks. You know, the first week here in Dublin - really, right before the lockdown happened, I was going through a pretty intense period of anxiety and sort of uncertainty. It really did seem kind of a little bit apocalyptic. And that coincided with the sort of ramp-up to my book coming out. So there was a lot of, I guess, dramatic irony surrounding my experience of it. You know, I'd written about all these kinds of scenarios. I'd written about people who were preparing for the end of the world in various ways. And there was just a lot of - yeah, a lot of dramatic irony.
At one point, I - you know, I bought a lot of sort of practical guides to surviving the end of the world - you know, doomsday-prepper guides and so on - when I was writing the book. And, you know, I read them at the time with, I guess, you know, in the spirit of scholarly interest and with a certain kind of arm's-length irony there. And I found myself taking one or two down off the shelf in that first week and sort of flicking through the index with something other than scholarly interests, I think it's fair to say.
But since then, you know, it's been interesting because so much of what I wrote about in the book has to do with not just kind of catastrophe scenarios or, you know, natural disasters or asteroids hitting or whatever. A lot of these people who I'm writing about, they're very focused on the prospect of civilizational collapse. So it's not necessarily the virus or the nuclear bomb that they're most focused on, it's civil unrest.
And it's - a lot of it is predicated on this notion that, you know, given a severe enough catastrophe, humanity is sort of bound to revert to savagery. And people will start looting and sort of, you know, stealing each other's stuff. And we'll sort of revert to an animalistic kind of original human nature. And I think - you know, with some sort of high-profile but relatively minor examples - certainly, where I am, what you're seeing is strengthening of community, a strengthening of civilization itself.
GROSS: So you write that your book is really also about the reality of anxiety and that everything in the pages of your book exists as a metaphor for a psychological state. I think it's the psychological state so many of us are experiencing now. So explain what you mean by that.
O'CONNELL: Yeah. Well, the book - I mean, the book didn't begin as a book about the apocalypse. It began, really, as me sort of trying to confront the sources of my anxiety. So, you know, I write in the first couple of pages of the book about a moment where I'm watching cartoons with my son. He's watching this cartoon about a bear and his sort of companion. And I'm sitting on the couch with him watching a polar bear starving to death and sort of trying to get some trash out of a trash can to eat.
And it began out of, like, a sense of the irreconcilable kind of energy of those - of these two kind of worlds, of the world of the outside - the news, things that are going on - and the kind of imperative of early parenthood, which, for me, has to do with trying to protect your kids, trying to instill in them the idea that the world is a beautiful and a good place. And I wanted to kind of explore the tension between those two things, which was a source of real anxiety for me. And it was only kind of a little bit later that the idea of the apocalypse kind of came into view as a way that I could give shape to those anxieties.
GROSS: Have you found that most of the people preparing for the end of the world are white and male?
O'CONNELL: Yeah. Certainly - so, you know, the doomsday preppers who I look at in the first sort of section of the book tended to be overwhelmingly male and overwhelmingly white and, you know, often conservative Christian. And the ideology that they bring to it is often one of, I would say, you know, quite right-wing, quite libertarian - a mistrust of the state and a kind of, I guess, a fetishization of ideas of kind of rugged self-reliance and masculinity and often, you know, fantasies of kind of defensive violence - so an idea of, you know, you have to protect your family. You have to protect your home. Often, that involves guns and so on, you know, particularly in American context. So yeah, it's not - it is something that I think appeals more to a particular kind of masculinity, a particular kind of man than it does to women. Although, there are, of course, female preppers.
GROSS: So let's talk about one of the places you went to to study the people who were really preparing for the collapse of civilization or the end of the world. You went to the Black Hills of South Dakota, where people planned to prepare for a nuclear war by living in a former Army munitions and maintenance facility that was built during World War II for the storage and testing of bombs. And you went there when tensions were really high between Trump and Kim Jong Un. And there really were fears about, you know, some kind of, like, nuclear weapon being used. So just describe this former storage and bomb testing site.
O'CONNELL: Yeah. It's a really extraordinary place. And part of it was - you know, part of the reason why I wanted to go there was that it just looked so otherworldly. It's a dairy farm, essentially, in the prairies of South Dakota, which, as you say, was used as a former munitions facility. So there are all these - I think it's 550 is the number. There's 500-and-something - anyway, sort of overground bunkers, reinforced concrete and steel kind of mounds coming out of the ground covered in grass. And it just looks like something out of an alien landscape.
But all of these are being converted into - so it's been bought by a kind of - I guess you would describe him as an apocalyptic real estate entrepreneur, a guy named Robert Vicino. And he bought the land and is selling off these bunkers for - I think it's $35,000 is the figure that he quoted me. And so the idea is that people buy these empty bunkers and convert them to their own sort of specifications. And this is a place for people to retreat to in the event of - I mean, yeah. Certainly, nuclear exchange is one of the big ones but, you know, also things like viral pandemics and any kind of situation that threatens civilizational collapse or, you know, civil unrest. And the idea is that there would be an army, like a private army, that would patrol the perimeter of this place to stop the - well, to stop the rest of us getting it, I suppose.
GROSS: So it's like a condo gated community, except you're living in bunkers and instead of a guard at the gate, you've got, like, a whole army (laughter) is...
O'CONNELL: Yeah. Yeah, I mean, it's...
GROSS: ...Protecting - it's quite a vision, yeah.
O'CONNELL: It is an extraordinary vision. And it seems like, I mean, it is a sort of a gated community. It's sort of I described in the book as, you know, a kind of a logical conclusion of the psychology of the gated community. Vicino, who started this survival community, is - he also makes kind of a luxury apocalyptic bunkers. So these are kind of, you know, pitched at the middle range of the market, the kind of the apocalyptic bourgeoisie, I suppose. But he sort of made his name building these very lavish luxury bunkers that are supposedly kitted out with, you know, private cinemas and wine sellers and all kinds of things.
GROSS: Living out the end of days in style.
O'CONNELL: Sure. Why not?
GROSS: You cite some pretty strange beliefs that he has including that there's a rogue planet called Nibiru that's heading toward Earth and might collide with it. What are some of his other beliefs that are motivating him?
O'CONNELL: Yeah. I mean, Vicino is an interesting character in that he doesn't seem to focus on any one particular apocalyptic scenario. So climate change interestingly is not a big issue with most of these people. So it's not that they're necessarily climate change deniers but just that climate change doesn't seem to offer the prospect of sort of total annihilation or total civilizational collapse. So things like asteroids hitting the planet, that's a big one. Viral pandemics as well, certainly, that's another one. But, yeah, I mean, this idea of Nibiru, which is, I guess it's - you know, it's a relatively sort of well-sort-of-subscribed conspiracy theory. There's zero evidence for it as far as I can tell and as far as most sort of scientists would tell you.
But I think the idea is that, you know, he's a salesman, and a lot of these people are salespeople. And so it makes sense to have a kind of a spread of apocalyptic scenarios. So if you don't subscribe to the Nibiru idea, which I certainly didn't, you know, someone like Robert Vicino has another apocalyptic scenario that he might be able to sort of hook you on. And a lot of our - I mean, it was a really interesting, kind of weirdly enjoyable, also quite antagonistic sort of exchange that we had because a lot of it had to do with him. You know, he approached me as he would anyone who was interested in his property, so he was trying to sell me the idea of the place. So a lot of it was him, you know, trying to sell me a bunker basically and giving me reasons why it might be sensible for me to have this for myself and my family.
GROSS: What's his sales pitch?
O'CONNELL: Something's going to get us. Something is going to come along eventually, whether it's an asteroid, whether it's a nuclear exchange, whether it's just sort of civilizational sort of atrophy, something will come along eventually that will make it unsafe. He's talking particularly in the United States context, but also, you know, he had sort of a pretty grim vision of global civilization.
But yeah, something is going to come eventually, and it will - you know, it will cause a civilizational collapse. And in a way what's happening now, although, as I've said, it's nowhere near any kind of civilizational collapse scenario, but, you know, you can imagine preppers and people like Vicino might be feeling somewhat vindicated and might be feeling even somewhat smug.
GROSS: Was there just a little bit of you that thought maybe I should invest in one just for safety?
O'CONNELL: You know, he's a really good salesman. He's like a really powerful persuasive salesman, and he's successful for a reason. So yeah. And I'm - you know, I quite enjoy people selling things to me. I'm fascinated by the kind of the psychology of salesmanship, and I like being sold to. So there were moments where I was open to it, yeah. But ultimately, I think what - where I landed with it is that I would not want to be part of that community. I would not want to be part of a protected sheltered elite or an elect that was being protected by a private army.
On some level, I think I'd rather be dead. I'd rather be outside and take my chances because it seems, you know, from an ideological perspective that is just too bleak and, yeah, too terrifying to me - the idea that that would be, you know, where I land with in the book is if you were preparing for the collapse of civilization in that way, I think, for you, civilization has already collapsed.
GROSS: Well, let's take a short break here and then we'll talk some more. If you're just joining us, my guest is Mark O'Connell. He is the author of the new book "Notes From An Apocalypse." We'll be right back. This is FRESH AIR.
(SOUNDBITE OF MUSIC)
GROSS: This is FRESH AIR. Let's get back to my interview with Mark O'Connell, author of the new book "Notes From An Apocalypse" about people who are preparing for a doomsday caused by environmental catastrophe, nuclear war, a pandemic, a comet crash, any number of things.
One of the places you went to research your new book was New Zealand. And there are wealthy people from the United States, maybe other places too, who are buying land in New Zealand because they see it as a safe, relatively isolated place not near major nuclear targets where they'd have a chance of not only living out a collapse in much of the world but also doing it in a land of great beauty and in comfort.
And several of the people - oh, oh, this is interesting. You write that two days after Trump's election, the number of Americans who visited New Zealand's Department of Internal Affairs to inquire about citizenship there increased by a factor of 15 compared to the same day in the previous month. Tell us more about New Zealand. Like, why New Zealand?
O'CONNELL: Well, I mean, that's why I went there I guess because I wanted to know why New Zealand. And, you know, in a way, it didn't take me that long to figure out why New Zealand because it is an insanely beautiful place, and if I had endless resources, I probably would want to buy a place in New Zealand, you know. You know, you could approach it as an apocalypse retreat or you could just - you know, it's a nice holiday. There's nice vineyards and so on.
So, you know, I guess if you have that kind of money, particularly, you know, Silicon Valley people tend to be quite rationalistic and, you know, there's a lot of interest in those circles in terms of, like, long-term forecasting of, you know, the future of civilization and so on, you can see the appeal because, you know, New Zealand is a very - it's a politically stable place, a lot of clean air, an abundance of lakes, fresh water. You know, it's far from everywhere else. So, you know, you don't have those kind of sort of threats that you would have in Europe and America. It's quite - you know, it's quite distanced in various ways. So you can see the appeal.
GROSS: Peter Thiel, who is the founder of PayPal and was an early investor in Facebook and is a billionaire, he has land in New Zealand. And you're right. One of the things that inspired him to think about New Zealand was a book called "The Sovereign Individual: How To Survive And Thrive During The Collapse Of The Welfare State." This was published in 1997. What is the vision this book offers?
O'CONNELL: "The Sovereign Individual" is - gives a very bleak and in some ways dystopian vision of a future in which the nation-state as a sort of a concept begins to fall away. And, you know, strong democratic governments are kind of on the way out. And what you get is the rise of what they call sovereign individuals, people who are very wealthy, have a lot of kind of intellectual capital, people like I suppose Peter Thiel who will sort of rise above democratic nation-states and become kind of more influential and more powerful than states themselves. And it predicts the rise of things like cryptocurrency and, you know, the future in which wealthy people will no longer be sort of beholden to the state by having to pay taxes and so on. It's just sort of a radically libertarian vision of the future. And it's a good thing from the point of view of the book that the state is on the way out.
GROSS: I'm wondering how the massacre at the mosque in Christchurch, New Zealand, where more than 50 people were murdered by someone with an assault rifle, what impact that had on people who see New Zealand as this safe space.
O'CONNELL: That came towards the end of when I was writing the book, and I'd already written the New Zealand chapter at that time. And I knew that I had to revisit it because, you know, it seemed to throw everything into a different light because, you know, the sort of premise of the idea of New Zealand as this sort of safe retreat from the rest of the world is that, you know, it's this fantasy, that it's not connected to these, you know, dynamics and vectors that are happening in the rest of the world. And, of course, that's not true. And this was, like, a really violent, tragic illustration of that fact. But what I saw was - you know, in the immediate aftermath, I remember watching - and I write about it in the book of course. I remember watching all these videos of, you know, Maori men doing the haka as a kind of a gesture of solidarity and grief.
And there's so much of this kind of communitarian response to this terrible act of, like, fascist violence that spoke to me, I think, of, like, the real heart of New Zealand and what makes New Zealand such a valuable place. It's not the - you know, obviously, it's a very beautiful country, but it's not the kind of - you know, what's valuable about New Zealand is not what people like Peter Thiel and so on value in the country. It's the kind of - it's the community aspects of the place.
GROSS: What is the reaction of people in New Zealand, particularly the Maori who are native to New Zealand, what is their reaction to New Zealand being seen as a safe space for people waiting out doomsday?
O'CONNELL: To put it sort of bluntly, I think a lot of New Zealand people, Maori in particular, see it as a kind of a return of the colonial mindset. So New Zealand as a country I think is unusual amongst kind of post-colonial nations of being absolutely open and absolutely resolute in having a kind of strong but nuanced kind of understanding of what colonialism meant in the history of the country and how to sort of move beyond those mindsets. And I think there is a suspicion of people like Peter Thiel and sort of wealthy Americans coming and buying up land that it might be a kind of a modern version of that sort of tragic colonial moment in the state's history.
GROSS: My guest is Mark O'Connell, author of the new book "Notes From An Apocalypse." We'll talk more after a break. And our critic at large John Powers will review two TV series he's become caught up in while social distancing. I'm Terry Gross, and this is FRESH AIR.
(SOUNDBITE OF BILL FRISELL'S "HELLO NELLIE")
GROSS: This is FRESH AIR. I'm Terry Gross. Let's get back to my interview with Mark O'Connell, author of the new book "Notes From An Apocalypse." It's about people preparing for a doomsday caused by environmental catastrophe, nuclear war, a comet crash, a pandemic. He visited a former bomb-testing facility that's being turned into bunkers by a survivalist entrepreneur. He went to New Zealand, where some Silicon Valley billionaires have bought land to wait out doomsday in a beautiful, remote location. He went to a conference of people who believe Mars should be turned into a backup planet for our doomed Earth. He's speaking to us from his home in Dublin, Ireland.
So let's talk about Mars and people who hope to use Mars as a backup planet when Earth is destroyed. Tell us about the thinking behind this.
O'CONNELL: Yeah. Well, so Mars almost is like the next step up from New Zealand, you know? If New Zealand is kind of the safest retreat on this planet, then, you know, if everything goes wrong here and the planet gets hit by an asteroid or whatever, Mars is kind of the term that is used amongst Mars enthusiast - an enthusiasts would be, we need a backup planet. So we need a backup planet for humanity in case something goes catastrophically wrong with Earth. You know, Elon Musk is always using this term. Elon Musk would be, I suppose, the most prominent kind of advocate of Mars exploration, obviously, with his space exploration company, SpaceX.
But yeah, it's, you know, again, things like climate change, the prospect of, you know, an asteroid strike - anything that could sort of present an existential threat. The idea is that, you know, even on the long-term kind of scale, the sun is going to burn out eventually. And the idea is that we need to sort of ensure the future of humanity. And so we need a kind of a second place to sort of - to form a backup for it, for civilization and for the species. And I found this just a fascinating kind of emanation of the apocalyptic kind of mood of our time.
GROSS: So one of the things that kind of baffles me, in a way, about this Mars colonization premise is that - I mean, I don't know that much about space travel. But I would assume that if Mars was actually colonized and used as a backup planet, that would be far enough into the future that the people who are in this movement now would not be alive by the time it happened.
O'CONNELL: I think some of them certainly would hope that they will be around for it. I think, you know, Elon Musk, for instance, who is kind of the major advocate of Mars colonization at this point, I think, I think he's pretty explicit about the fact that he wants personally to get to Mars. So you know, these are optimistic people. And, you know, a lot of them do believe that they will get to Mars - or at least humans will get to Mars in our lifetimes.
But yeah, I mean, it is very much a long-term sort of long-scale project. And it's about, you know, as I say, having a backup planet for civilization. So it's not - you know, as much as certain individuals might want to see Mars in their time, it's not really about the individuals. It's about the idea of, you know, preserving the species. If, you know - if an asteroid hits Earth or if the sun explodes or whenever, you want to have a backup planet for humanity. And that's, you know, where Mars is - kind of comes into it.
GROSS: One of the places you went to was Chernobyl. Why did you want to go there? People are not building bunkers in Chernobyl (laughter). No one wants to live on the site...
O'CONNELL: No, no.
GROSS: ...Of a nuclear catastrophe.
O'CONNELL: Well, you know, I wanted to see what the end of the world looked like, in a way. And I also wanted to see what a kind of an - like, a catastrophic event on the order of Chernobyl, what happens afterwards? And I was fascinated by the ways in which life is kind of returning to this place in ways, you know? Nature is thriving there. And not only nature, but people are living there. There are, you know...
GROSS: They are, yeah?
O'CONNELL: Yeah. There's a relatively small number of people, you know, in the dozens. But there are - and, you know, generally older people who have returned there to live in their houses that they evacuated in the immediate aftermath of the disaster. And so there are people living there. But ultimately, what I was really interested in was, you know, catastrophe tourism. There are tour companies that have set up in and around Kyiv who will bring you there.
And you can stay overnight, which is what I did on the tour. And, you know, you get to explore Pripyat, which is the abandoned city that was purpose-built for the workers in Chernobyl. And there's a just - it's a fascinating kind of insight into the sort of visual spectacle of the apocalypse, you know? You get to wander around this kind of diorama of a sort of post-apocalyptic future. And I think that's what attracts the people who are on this tour and, you know, to some extent, myself.
GROSS: So what does it look like?
O'CONNELL: It's pretty grim (laughter). You know, I went - it was a beautiful day, you know, the two days I was there. So - you know, nature has reclaimed the place. Pripyat is full of, like, you know, nature just bursting forth out of concrete. And there is something sort of quietly beautiful about it. And there's, you know, wolves. It has quite a large population of wolves there. So life is kind of going on without humanity. So there's something - as bleak as it is, there's something slightly reassuring about that. I wouldn't recommend it as a honeymoon destination or a sort of weekend getaway...
GROSS: (Laughter).
O'CONNELL: ...But that's not what I was there for.
GROSS: How much did the tour cost?
O'CONNELL: The tour, it was - I think it was something around, maybe, 250 pounds, which is a lot of money in Ukraine. I think it's close to, like, you know, a monthly wage. So it's a huge amount of money. But they bring you on the tour from Kyiv. So you get on the tour bus outside of McDonald's in Maidan Square. And it's about a two-hour drive to the zone. And then, you know, it's heavily sort of controlled or patrolled by the army still at this point. So you need a passport to get in. And they check your passport. And you're sort of rigorously checked for radiation at various points along the way towards the power plant.
And, you know, they bring you in this place and show you what - you know, what it was like to live in this place and what it's like now. You know, it's a pretty - there are some, you know, threats of, you know, pockets of radiation that are quite high. But in general, the cleanup was very successful. And, you know, the guides know where they're taking you. So you don't stray into any particularly, you know, hotspot zones or whatever. The one thing they do tell you is don't eat the moss. I wasn't going to eat the moss anyway. But they're quite...
GROSS: (Laughter).
O'CONNELL: ...Quite sort of strict about eating anything from the ground, particularly moss. Moss soaks up a lot of radiation. So if you do go to Chernobyl, do not eat the moss.
GROSS: So you weren't worried about exposure to radiation on the tour?
O'CONNELL: Well, you know, you've read my book. So you know I'm quite an anxious. So I did find ways to be worried...
GROSS: (Laughter).
O'CONNELL: ...You know, mostly after the fact. Like, you know, I got back from the two-day tour and I was like, well, what did I do? Why did I stay overnight in Chernobyl? Why was I, you know - was it worth it? I'm still - you know, I'm OK.
But I think the thing that you realize pretty quickly is that almost everywhere you go, the levels of radiation are actually lower than they would be. You know, they measure the radiation with a dosimeter outside McDonald's in - the McDonald's in Kyiv. And it's quite a bit higher than it is in most of the places where you are in the zone. So any kind of built up urban area would probably have higher radiation levels than any of the places where you actually go on the tour in the zone. Now, there are places where you just don't want to be within the zone. The power plant itself, certain spots there are still incredibly high. But you don't go anywhere near those.
GROSS: Well, let's take a short break here. And then we'll talk some more. If you're just joining us, my guest is Mark O'Connell. His new book is called "Notes From An Apocalypse." We'll be right back. This is FRESH AIR.
(SOUNDBITE OF AWREEOH SONG, "CAN'T BRING ME DOWN")
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Author Tours The 'End Of The World,' From Prairie Bunkers To Apocalypse Mansions - West Virginia Public Broadcasting
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Spaceship Earth Trailer: Experience the 1991 Quarantine Experiment That Rocked the World – IndieWire
Posted: at 3:05 pm
Matt Wolfs Sundance Film Festival documentary Spaceship Earth arrives at quite a moment in history, as the film ponders a science experiment that wanted to find the good, and science-expanding possibilities, in self-imposed quarantine. Check out the first trailer for the film below, which Neon will release in May on digital platforms including the websites of restaurants, bookstores, and other small non-theatrical businesses as distributors get used to skipping theatrical in these crazy times.
Spaceship Earth is the true, stranger-than-fiction adventure of eight visionaries who, beginning in 1991, spent two years quarantined inside of a self-engineered biome called Biosphere 2. The glass terrarium deep in the Arizona desert sought to replicate earths ecosystem, end became a pilot program for Mars colonization. The experiment became a global phenomenon, chronicling daily existence in the face of life-threatening ecological disaster, from food shortages to oxygen deprivation, while contending with growing assumptions from the media and beyond that the Biosphere inhabitants were nothing but a mad cult. Biosphere 2 soon found itself labeled as the product of science-fiction, not credible science, from a pack of 60s hippies. The $200-million research facility, of course, became a tourist attraction, tarnishing its integrity and reputation along the way.
Out of Park City, Variety called the film a lovely, engrossing documentary flashback. Spaceship Earth reclaims Biosphere 2 from the pop-culture-footnote dustbin, capturing the spirit of genuine idealism and earnest scientific inquiry An involving, oddly poignant tale that should have broad appeal to those on the lookout for distinctive documentary features has the excitement and involvement of a fictive sci-fi narrative.
Matt Wolfs previous documentaries include Recorder, about activist and pioneering television archivist Marion Stokes, who taped 35 years worth of cable news on her eight VCRs; Wild Combination, a documentary about cult queer musician Arthur Russell, who died of AIDS in 1992; and Teenage, about the evolution of youth culture throughout history based on a book from Jon Savage. Spaceship Earth, which looks to blend Wolfs interests in science and in counterculture, world-premiered in the US Documentary Competition of the 2020 Sundance Film Festival, where it competed for the Grand Jury Prize.
Spaceship Earth is another entry in distributor Neons growing slate of distinctive documentary films, including last years Honeyland, which earned multiple Academy Award nominations, and Apollo 11. Watch the trailer below.
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Spaceship Earth Trailer: Experience the 1991 Quarantine Experiment That Rocked the World - IndieWire
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Promising technologies that will change cancer testing in India – Express Healthcare
Posted: April 21, 2020 at 7:48 pm
All these technologies show amazing promise and some of them are already in use. The scientific community in India is constantly pushing their limits to get to a stage where the diagnosis of cancer will not be a life-altering event for patients
In the last few decades, cancer has become a leading cause of mortality worldwide. According to the WHO, currently, around 10 million new cancers are diagnosed each year worldwide, but unless there is an effective prevention campaign, the number will rise to 20 million in the next 17 years time. Therefore, the global scientific and healthcare community are turning to novel approaches in an attempt to make sure those grim projections dont continue to haunt us. Stronger and effective cancer treatments are certainly part of the development goals, but a premium is also being put on early diagnosis to ensure better medical outcomes and assured prevention.
Today, more focus is given to precision medicine-quantitation, multiplexing and highly precise identification of markers. Precise tools which were once utilised in research settings are now applied in clinical practice with just one goal in mind- faster and more efficient cancer testing.
In this article, we examine top technologies that will improve efficiencies and precision in cancer diagnostics and prevention in India.
Fluid biopsies: Many scientific publications have documented that liquid or fluid biopsies are informative regarding response to a given therapy, are capable of detecting relapse with lead time compared to standard measures, and reveal mechanisms of resistance. According to Dr BS Ajaikumar, Chairman and CEO, HCG Global, liquid biopsy plays a significant role in those cases where it is difficult to establish a tissue diagnosis in a recurrent or metastatic setting. It is a simple minimally invasive procedure done on blood, plasma or urine sample to identify the genetic material of tumour cells either as ctDNA (Circulating tumour DNA) or CTC (Circulating Tumour cells) or cfDNA (Cell-free DNA) by identification of cancer-associated DNA / RNA / exosomes.
He further lists down some benefits of the same:
Real-time cancer diagnostics: With the need to need to translate recent discoveries in oncology research into clinical practice, cancer experts believe that objective, robust and cost-effective molecular techniques for clinical trials and, eventually, routine use is a must. Real-time PCR has become a useful and cost-effective technique for tumour profiling among clinical laboratories.
Dr Kirti Chadha, Head of Laboratory at Metropolis Healthcare expounds, The pathogenesis of tumours is complex making the surgical management more difficult. Here comes the role of real-time diagnostics which will give an on-table diagnosis to make the treatment successful. A lot of research is going on it like an intelligent surgical knife has been developed by using an old technology where an electrical current heats tissue to make incisions with minimal blood loss, but with this technology, the vapourised smoke is analysed by a mass spectrometer to detect the chemicals in the biological sample allowing identification of malignant tissue. Also, a robotic platform has been developed in treating lung cancer. It combines robotics, software, data science and endoscope innovation to help diagnose lung cancer at an early stage with more accuracy and a lower risk of complications. Similarly, realtime detection of breast cancer at the cellular level by a multispectral confocal scanning system has been developed. These are at research levels or some of them are being approved for use. Introducing advanced technology to traditional methods can also give us better real-time solutions like using digital pathology.
Digital PCR: Digital PCR is the latest and advanced iteration of a conventional quantitative RT-PCR for sensitive and accurate measurement of DNA/RNA from samples. The primary principle behind the technique is similar to q-PCR but differs in the way the sample target is analysed.
Dr Dheeraj Gautam, Head of Department Department of Histopathology, Associate Director- Department of Pathology and Lab Medicine, Medanta- The Medicity says, PCR is a common test used to make many copies (millions or billions) of a particular region of DNA. With best systems, we have the capability to detect as few as ~10 copies of DNA templates. It is routinely used in DNA cloning, cancer diagnostics, and forensic analysis of DNA. For example, it might be a DNA sequence (gene) from a crime scene to match crime suspect, by forensic scientists. Typically, the goal of PCR is to amplify enough of the target DNA region, so that it can be analysed to deliver useful scientific information. Presently, Coronavirus is being tested by this method.
Adding to this, Dr Ajaikumar informs, Digital PCR is a simple and reproducible technique that does not rely on a calibration curve for sample target quantification. Digital PCR works by partitioning a sample of DNA into many individual, parallel PCR reactions. Following PCR amplification, the number of positive vs negative reactions is determined and the absolute quantification of target calculated using Poisson statistics. The benefits are, high precision, better signal to noise ratio, removal of PCR efficiency bias and simplified quantification.
Speaking about the areas in which Digital PCR is currently applied, Dr Chadha reveals, dPCR is currently being applied for absolute allele quantification, rare mutation detection, analysis of copy number variations, DNA methylation, and gene rearrangements in different kinds of clinical samples. The form of digital PCR ie. Digital droplet PCR(ddPCR) is performed in Metropolis for circulating tumour DNA(ctDNA), EGFR/KRAS/NRAS/BRAF mutations in lung and colorectal cancer.
Chromosome Analysis: Since altered genetic mechanisms lead to the development of cancer, chromosome analysis plays a significant role in the diagnosis and treatment monitoring of patients with various types of cancer. Chromosome analysis can be done by karyotyping and CGH(Comparative Genomic Hybridisation) array.
Dr Ajaikumar explains the various techniques that follow under chromosome analysis:
Cytogenetics(Karyotyping and FISH): FISH can identify chromosomal abnormalities such as insertions, deletions, translocations and amplification, through the use of fluorescent dyes that bind to sequences of interest. It is well known that certain types of cancer have specific genetic alterations. So far > 200 rearrangements and fusions have been identified. Examples include BCR-ABL translocation in CML, ALK rearrangement in NSCLC, Her-2 in Breast Cancer, Synovial sarcoma with t(X:18) (p11.2;q11.2), Ewings Sarcoma with t(11:22) (q24;q12.2). FISH is applied to detect genetic abnormalities that include different characteristic gene fusions or the presence of an abnormal number of chromosomes in a cell or loss of a chromosomal region or a whole chromosome. It is also applied in different research applications, such as gene mapping or the identification of novel oncogenes. FISH has high sensitivity and specificity. With microfluidics FISH, it can be faster and less costly.
Immunohistochemistry: Provides a platform for identification of certain chromosomal alterations through detection of proteins. Examples are the Her-2 testing in Breast and gastric cancer, ALK in NSCLC, TFE3 in Alveolar Soft Part Sarcoma, MDM2 and CDK4 in certain soft tissue sarcomas like Liposarcomas. They have high sensitivity and specificity of almost 95-97 per cent. They also provide targets for drug therapy.
Molecular testing: Through PCR, Direct sequencing, DNA and Protein microarray techniques and the latest path-breaking technology of NGS. PCR and sequencing are useful when we want to look for the presence of a known genetic alteration such as EGFR mutation in lung adenocarcinoma. But when the alterations are unknown or are likely to involve many loci, a panel of genetic markers can be screened through Next-Generation sequencing.
Next-Generation Sequencing (NGS): Massively parallel deep sequencing of a large number of patients with a variety of cancers to analyse the mutation profile of tumours at one go provides a comprehensive understanding of the processes that drive an individuals cancer. This will break the cycle of trial and error medicine, and link the test to patient-tailored action and evidence-based therapy/ treatment plan in cancer. Furthermore, using genomic markers as response predictors to chemotherapy will dramatically improve response rates impacting the risk-benefit ratio for these patients.
Cell Signaling Pathway Testing: According to experts, cancer is caused by genetic and/or epigenetic changes in one cell or a group of cells. These alterations disrupt normal cell function and cause cancerous cells to proliferate and avoid mechanisms that would typically control their growth, division, and migration. Many of these disruptions map to specific cell signalling pathways. These pathways are involved in deregulated cell survival, cell differentiation and apoptosis. They form the hallmark of cancer that include immune evasion, replicative immortality, activate invasion and metastasis, induce angiogenesis, resist cell death, deregulate cellular energetics, sustained proliferative signalling, evading growth suppressors, possess genome instability and mutations, and mediate a tumour associated inflammatory response. Signalling pathways such as Ras proteins through Raf-MEK-Extracellular signal-regulated kinase (ERK) and PI3K-AKT-mTOR pathways regulate cell survival, cell proliferation and migration/invasion in response to matrix adhesion and growth factor stimulation. Three Ras proteins KRAS, NRAS and HRAS become mutationally activated and promote oncogenesis. Also identified are Wnt/Beta Catenin signalling in APC and NF2 gene in Neurofibromatosis Type 2. Certain growth factors such as RTK-VEGF, TGF Beta, PTEN in several types of cancers, are detected with either FISH or IHC or ELISA or other molecular profiling such as NGS more accurately and form the target for drug therapy.
Tissue microarrays: Tissue microarray technology overcomes the bottleneck of traditional tissue analysis and allows it to catch up with the rapid advances in lead discovery.Dr Chadha further explains, Tissue microarrays consist of paraffin blocks in which up to 1000 separate tissue cores are assembled in array fashion to allow multiplex histological analysis. It is a recent innovation in the field of pathology. A microarray contains many small representative tissue samples from hundreds of different cases assembled on a single histological slide, and therefore allows high throughput analysis of multiple specimens at the same time. It can permit simultaneous analysis of molecular targets at the DNA, mRNA, and protein levels under identical, standardised conditions on a single glass slide, and also provide maximal preservation and use of limited and irreplaceable archival tissue samples. This versatile technique, in which data analysis is automated facilitates retrospective and prospective human tissue studies. It is a practical and effective tool for high-throughput molecular analysis of tissues that is helping to identify new diagnostic and prognostic markers and targets in human cancers and has a range of potential applications in basic research, prognostic oncology and drug discovery. This technique is very versatile as many downstream molecular assays such as immunohistochemistry, cytogenetic studies, Fluorescent In situ-Hybridisation (FISH) etc., can be carried out on a single slide with multiple numbers of samples.
Adding further, Dr Ajaikumar points out, The field of biomarker research can further be escalated by the integration of TMA technology with digital pathology. The most important disadvantage of this technique is that one small tissue core may not be representative of the whole tumour analysed conventionally. Therefore, many such cores of the same may be required to carry out analysis to arrive at a definitive conclusion. This is mainly significant for heterogeneous tumours like a human ovarian tumour. Whether this technology is useful in heterogeneous tumours is still highly debated.
Artificial intelligence-based therapy: Many cancer care experts believe that integration of AI technology can improve the accuracy and speed of diagnosis, aid clinical decision-making, and lead to better health outcomes. AI-guided clinical care has, therefore, the potential to play an important role in reducing health disparities, particularly in low-resource settings.Dr Gautam exemplifies how AI integration can be done in cancer diagnosis. A pathology AI system is a computer programme that assists pathologists in their work or provides automated pathology. Machine learning allows learning a task from data, like providing a diagnosis or a score, or a subtask, like classifying different cancers. A deep learning network is able to learn highly complex visual features just from the image data, achieving expert human performance, he describes.
Similarly, citing more examples, Dr Chadha spells out, AI also has gained importance in therapy designs, for e.g. Google is collaborating with health delivery networks to build prediction models from big data to warn clinicians of high-risk conditions, such as sepsis and heart failure. A neural network was applied to identify breast cancer with the inputs from mammographic images. A convolutional neural network was also performed to identify skin cancer from clinical images. Many start-ups are developing AI-derived image interpretation algorithms and can identify the patients at most risk as well as those likely to respond to treatment protocols. Digital pathology is one such platform which can be used for AI interpretations and diagnosis. Metropolis is one of the first CAP & NABL approved labs in India to adopt this platform. Scanning of slides to create a database which can be used for machine learning and AI-derived image interpretation.
On the anvil
As the scientific community continues to move ahead there will be cross-fertilisation of tests and technologies in the future. Oncologists and histopathologists also indicate a growing significance of pharmacodiagnostics in cancer care due to the development of new improved targeted drugs.
Adds Dr Chadha, This emerging and expanding speciality with major potential for the specific linking of a treatment outcome like a response, toxicity and resistance to a key molecular alteration (e.g. protein overexpression or gene amplification) within a disease state to predict therapeutic response. It is used in measuring response or adverse side effects of both established and newer therapies. In oncology, recent advances with targeted therapeutics have demonstrated the critical importance of appropriate pharmacodiagnostic approaches. It is based on identifying somatic molecular changes in the tumour which forms the basis of molecular targeting of many novel therapies. The development of Herceptin (targeting the human epidermal growth factor receptor (HER2) oncogene in breast cancer) and Glivec (targeting BCR-ABL translocation in leukaemia) are excellent examples of the close relationship between target expression, pharmacodiagnostic tests and clinical therapeutic response. As treatment response depends on the molecular profile of individual cancer, the major challenge for the future will be to co-develop novel targeted therapies and pharmacodiagnostic tests also called as companion diagnostic tests that will predict patient response to therapy. To successfully integrate novel pharmacodiagnostics into clinical practice the collaboration between pharmaceutical and diagnostic industries, clinical oncologists and researchers must be strengthened.
Going forward, experts reveal immense opportunities for IVD companies to thrive in this business segment. But to be successful, IVD companies must demonstrate the impact their technologies will have on physicians decisions and patient outcomes.
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Promising technologies that will change cancer testing in India - Express Healthcare
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An astronaut spotted SpaceX’s Starlink internet satellites from the International Space Station – CNBC
Posted: at 3:45 am
A photo taken by an astronaut from the International Space Station on April 13, 2020.
NASA
An astronaut on the International Space Stationlast week captured a unique view of SpaceX's Starlink satellites photographing a group of the satellites in space, from space.
Starlink isSpaceX's plan to build a network of about 12,000 small satellites to provide high-speed internet to anywhere in the world.The company has launched 360 Starlink satellites in the past year and aims to begin offering early, limited service later in 2020.
The train of Starlink satellites that were photographed areSpaceX's fifth Starlink launch.
A cropped and edited photo shows the trail of Starlink satellites in this photo taken by an astronaut from the International Space Station on April 13, 2020.
NASA
Jonathan McDowell, an astronomer at the Harvard-Smithsonian Center for Astrophysics, shared a data visualization of the locations of the Starlink satellites when the photo was taken.
The location of SpaceX's Starlink satellites (red) compared to the International Space Station (blue) on April 13, 2020.
Jonathan McDowell
Starlink is an ambitious project that will require billions in capital to succeed, given the costs of building the required ground infrastructure in addition to the hardware and operating costs of the satellites in space.SpaceX has said it expects it will cost about $10 billion or more to build the Starlink network.
Starlink will make the company the world's largest satellite operator by number of spacecraft.If SpaceX can overcome the technological challenges of building and distributing this service, the company is optimistic on its potential demand and revenue. SpaceX CEOElon Muskin May told reportersthat Starlink could bring in revenue of $30 billion a year or about 10 times the highest annual revenue it expects from its core rocket business.
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Astronauts Return to Earth From International Space Station – EcoWatch
Posted: at 3:45 am
In Africa, for example, there are fewer than 2,000 working ventilators in public hospitals across 41 African countries, the World Health Organization says, compared with more than 170,000 in the U.S., as The New York Times reported.
Ten countries in Africa have none at all.
Somalia's Health Ministry has none. The Central African Republic has three. South Sudan has four, which is one fewer than the number of vice presidents it has. Liberia has five. Nigeria, with a population of over 200 million, has fewer than 100, as The Washington Post reported.
The paltry number of ventilators across the continent means that patients who appear at hospitals with the most severe acute respiratory symptoms from the novel coronavirus have little chance of surviving. While the number of ventilators is expected to increase as donations trickle in, few doctors across the continent have had the extensive training necessary to use them. Also, the ventilators usually require an anesthesiologist to intubate patients, or at least supervise the process, but anesthesiologists are scarce in Africa, according to The Washington Post.
The shortage of ventilators, training and specialists required to make them functional is only part of the massive shortage in resources that poorer countries face during the global pandemic. Health officials have also warned about a dire shortage of oxygen and masks. Even soap and water are in short supply.
According to the United Nations, only 15 percent of sub-Saharan Africans had access to basic hand-washing facilities in 2015. In Liberia, UN numbers showed that in 2017, 97 percent of homes did not have access to soap and clean water, according to The New York Times.
"The things that people need are simple things," said Kalipso Chalkidou, the director of global health policy at the Center for Global Development, a research group, as The New York Times reported. "Not high-tech things."
As of Saturday, there were more than 21,000 confirmed coronavirus cases and 1,000 deaths across the continent. The World Health Organization said that the virus appears to be spreading away from Africa's capital cities. The UN Economic Commission for Africa warned that 300,000 could die and called for a $100 billion safety net for the continent, including halting external debt payments, as the BBC reported.
"Anywhere between 300,000 and 3.3 million African people could lose their lives as a direct result of COVID-19, depending on the intervention measures taken to stop the spread," the United Nations Economic Commission for Africa said in a report released Friday.
The problem, according to the UN agency, rests partly with the layout and infrastructure of some of Africa's biggest cities, where the majority of the urban population lives in overcrowded neighborhoods without reliable access to hand-washing facilities, as NPR reported.
"We are now failing. Let me use that word deliberately," said Mahad Hassan, one of Somalia's few epidemiologists and a member of the government's coronavirus task force, as The Washington Post reported. "At our main treatment center, almost nothing is there. Last time I visited, beds, only beds. No oxygen, no ventilators."
Liberia's minister of information explained to The New York Times that attempts to procure medical equipment run into problems like wealthier countries hoarding supplies, bidding against other governments, and price gouging by suppliers.
"We keep fighting with our neighbors and the big countries. Even having a contract is not a guarantee we're going to get a supply," Eugene Nagbe, the minister of information said. One vendor, after entering a contract, turned around and raised the price from the agreed-upon $15,000 per ventilator to $24,000, he added, as The New York Times reported.
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Astronauts Return to Earth From International Space Station - EcoWatch
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NASA to launch astronauts to space station from US soil for the first time in a decade – WESTERNMASSNEWS.com
Posted: at 3:45 am
(CNN) -- Next month, human spaceflight will return to US soil after nearly a decade.
NASA announced Friday that SpaceX will launch astronauts Doug Hurley and Bob Behnken on a mission to the International Space Station on Wednesday, May 27 at 4:32 p.m. ET. Liftoff will be from Florida's Kennedy Space Center marking the first time a rocket will carry astronauts into orbit from the United States since NASA's Space Shuttle program retired in 2011.
It will also be the first crewed mission for SpaceX since its founding 18 years ago.
Because of Covid-19, however, there will be no crowds of spectators lining the beaches and viewing sites along Florida's Space Coast to watch the craft hurtle toward the ISS, as they have for the launch of nearly every crewed US mission since Alan Shepard became the first American to reach space in 1961.
Only a limited number of reporters will be allowed on site, and NASA said it will not host any members of the public.
"This has become yet another footnote in the story of coronavirus and its impact on America," said Dale Ketcham, a vice president at Space Florida, a local industry group. "But NASA is continuing to press ahead with Commercial Crew because there is a profound obligation to keep space station operational."
NASA has shut down many of its activities in response to coronavirus, but it has maintained all ISS-related activity. NASA astronauts Jessica Meir and Andrew Morgan returned from their stay on the space station aboard a Russian spacecraft on Friday.
The ISS has continually hosted a rotating crew of astronauts from all over the world since 2000. The United States and Russia are the space station's primary operators, but since 2011, Russia has been the only country capable of transporting astronauts to and from the ISS.
NASA has paid up to $86 million per seat and about $55.4 million on average to fly US astronauts aboard Russia's Soyuz spacecraft, according to the space agency's inspector general.
Years ago, NASA asked the private sector to develop a new generation of crew-worthy spacecraft. SpaceX was allotted $2.6 billion and Boeing was awarded $4.2 billion in 2014, and the space agency initially predicted their vehicles would be ready to fly astronauts by 2017. But development of both spacecraft took years longer than expected.
The companies were neck-in-neck, but SpaceX emerged as the clear leader after completing a successful test of its Crew Dragon spacecraft's emergency abort system in January. Less than a month earlier, Boeing's Starliner spacecraft suffered major setbacks during an uncrewed orbital flight test. The company has since said it will repeat that test mission in the fall.
The Crew Dragon mission in May, dubbed Demo-2, will be the final test for Crew Dragon before NASA transitions to operational crewed flights to the space station using the spacecraft.
Hurley and Behnken are both former military test pilots and veteran astronauts who previously flew on space shuttle missions.
After launching on May 27, they will spend as many as 110 days in space, though NASA said the "specific mission duration will be determined once on station based on the readiness of the next commercial crew launch."
They'll return on the Crew Dragon capsule, which will navigate back through Earth's atmosphere and splash down just off Florida's Atlantic Coast.
Though the US space agency paid the companies to develop their vehicles, Starliner and Crew Dragon are privately owned and operated. Unlike previous human spaceflight programs, NASA is essentially a customer of the companies.
SpaceX and Boeing have both announced plans to fly tourists aboard the spacecraft alongside NASA astronauts.
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NASA to launch astronauts to space station from US soil for the first time in a decade - WESTERNMASSNEWS.com
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NASA astronaut, UCSD grad to return to earth from space station – – KUSI
Posted: at 3:45 am
April 16, 2020
Posted: April 16, 2020
Updated: 11:36 PM
KUSI Newsroom
SAN DIEGO (KUSI) NASA astronaut and UC San Diego graduate Jessica Meir is scheduled to return to Earth Thursday evening after 205 days in space.
Meir, along with fellow NASA astronaut Andrew Morgan and cosmonaut Oleg Skripochka, with whom she servedaboard the International Space Station, will depart the station at 6:53 p.m. Pacific time with a parachute-assisted landing slated for 10:17 p.m. Pacific time in Kazakhstan, according to a NASA statement.
Meirs spaceflight included her participation in the first three all- woman spacewalks along with fellow NASA astronaut Christina Koch.
NASA says Meir has made 3,280 orbits of Earth and traveled nearly 87 million miles.
Meir tweeted a few photos Wednesday of various locations across Earth, including a view from space of San Diego, focused on UCSD.
She wrote Yesterday, @Space_Station flew over almost every place Ive ever lived, ranging from Canada to France all within 8 hours. Mother Earths way of calling me home?
Full coverage of the station departure will begin at 3 p.m. Pacific time at https://www.nasa.gov/nasalive, which will feature coverage of the landing beginning at 9 p.m.
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NASA astronaut, UCSD grad to return to earth from space station - - KUSI
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Amazing shots of International Space Station over Swindon (and here’s when you can see it next) – Swindon Advertiser
Posted: at 3:45 am
THE coronavirus lockdown has provided the perfect opportunity for stargazers to catch a glimpse of the International Space Station.
The fast-moving ISS orbits the planet 16 times a day at 17,500mph. Plummeting air pollution levels and a lack of planes in the sky have made it easier to spot on a clear night.
Gareth Breen, a map-maker from Covingham, has always had an interest in photography but it took the government restrictions for him to put some effort into his newfound hobby.
He told the Adver: It was basically to stave off boredom a little bit, but Ive always been interested in space observation, the night sky and photography in general.
Ive had a DSLR (digital single-lens reflex camera) for about 10 years and never known how to use it.
With all this extra time weve had its just the perfect opportunity to try something new.
Gareth used information from YouTube and Google to get himself set up and shared some tips with the Adver for those looking to match his amazing results.
He said: I used an app on my phone thats a star chart which you can point at the sky and itll tell you whats there. One app called Heavens Above will show you a live feed of all the satellites and the space station and when itll be overhead and how long for.
So youve then got time to set up your camera.
With the photos themselves, dependent on the light or how dark the sky is, you can set the exposures and the ISO and aperture to allow as much light into the camera as possible so it captures the station going across the sky.
How long you leave the shutter open and how big the aperture is will affect what you see. Its about the amount of time the shutter is open.
Its a lot of trial and error, my wife was quite happy because I was out in the back garden for an hour or two just testing things out.
To find out when the space station will next be over Swindon you visit spotthestation.nasa.gov/home.cfm
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Amazing shots of International Space Station over Swindon (and here's when you can see it next) - Swindon Advertiser
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UFO Spotted On NASA Live Stream Video Outside The International Space Station Is Absolutely Real – BroBible
Posted: at 3:45 am
Looks like weve got another NASA live stream from the International Space Station (ISS) on our hands possibly revealing yet more clues about UFOs and extraterrestrial life than the government would like us to know.
It happened back in November in what one expert called 100 percent proof that NASA and Russia know aliens visits the International Space Station.
And it occurred again in February with the person in the video sounding dismayed and unprepared for its sudden appearance.
Now, in April, we have yet another NASA video from the ISS in which UFO and alien expert Scott Waring says on his web site while discussing the footage, This UFO looks like a classic disk design. The metallic glint is unmistakable.
It looks to be in lower orbit as the space station passes it in upper orbit. Awesome catch, very rare, but absolutely real.
This is what NASA does not want the public to see, but this UFO was so faint and so small that Im sure they missed it, especially since most NASA is at home on lock down, probably fooling around instead of doing real work.
He is speaking about the second sighting documented on the video below which begins at around the 4:20 mark. He believes the first sighting in the video was not aliens
Two months ago, Waring was watching the NASA live space station cam and captured a 22-minute long video of a UFO sighting near the ISS. In that video, he points out, They [NASA] are as baffled by it as I am. They dont know what it is or why it is there.
He goes on to speculate that with the pandemic spreading like a wildfire out of control, its possible that aliens know what going to happen and they decided abandon the Earth. The virus may be very dangerous to aliens too. If this is true, expect to see a big rise in UFO sightings as they appear from underground bases and leave Earths atmosphere.
We have most certainly seen a big rise in UFO sightings over the past couple of months. No doubt about that. The question is, are the aliens leaving, as he suggests, or are they monitoring their handiwork and reporting back?
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UFO Spotted On NASA Live Stream Video Outside The International Space Station Is Absolutely Real - BroBible
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