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Category Archives: Transhuman News

Its In The Genes? Scientists Think Coronavirus Exploits Silent Hidden Mutations In The Body – International Business Times

Posted: May 11, 2020 at 11:43 am

KEY POINTS

Health experts have been baffled as to why there are people infected with COVID-19 and yet barely feel the infection while others suffer life-threatening symptoms even if healthy and young. Scientists are looking for answers in the genes of patients, trying to discover mutations that affect the immune response, hoping that it could help in coming up with new treatments.

Profile Of A Severe Case

During the early days of the pandemic, a general profile of a severe case of coronavirus infection started to emerge. They are older adults with pre-existing medical conditions and are likely to be male. As the virus continued to infect more people, a small fraction started to deviate from the general profile.

Health experts are starting to see around 5% of those infected are under the age of 50 and do not have any underlying health conditions. These are the group of patients that interest Dr. Jean-Laurent Casanova, a geneticist and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases.

Dr. Casanova told the AFP it is possible for someone who joined a marathon in October 2019 to find himself in intensive care, ventilated and intubated in April 2020. He revealed his desire to know if these types of patients have rare genetic mutations that have been triggered by the coronavirus infection. The assumption is that these patients have genetic variations that are silent until the virus is encountered, the doctor said. coronavirus silent mutation in human body may be the one exploited by the virus Photo: TPHeinz - Pixabay

A Huge Global Effort

The geneticist co-founded the COVID Human Genetics Effort, a collaborative work that seeks to know more about the genome of severely-ill young patients in several countries worldwide. These include patients in Europe, Japan, Iran, China, and the United States.

Dr. Casanovas group is also studying those who did not get infected despite being exposed many times. He said their main goal is to know why some are sicker than others, a knowledge that the geneticist said might help them in their quest to develop anti-viral therapies.

Gene Mutations Have A Long History

Scientists have long known that gene mutations can make people more susceptible to an array of infectious diseases, ranging from influenza to viral encephalitis. These gene mutations can also offer protection sometimes.

In the 1990s, a group of researchers found out that some rare mutations of a single gene successfully protected people against HIV infection. This discovery led to a betterunderstanding of how the virus worked and eventually paved the way for scientists to develop new treatments.

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MET 2020 Slot booking to commence on July 15, Examination dates available at manipal.edu – Jagran Josh

Posted: at 11:43 am

MET 2020 Slot Booking: The Manipal Academy of Higher Education will be conducting the Manipal Entrance Test 2020 from July 24 to 27 and August 4 to 7, 2020. According to a recent announcement made, the Manipal Entrance Test 2020 will be conducted in the online mode. The slot bookings for the entrance tests will be open from July 15, 2020, onwards. Candidates who have applied for the entrance test can visit the official website for more details related to the entrance test.

The instructions to be followed by candidates during the slot booking process is available on the official website. Candidates are advised to read through the instructions provided carefully in order to complete the slot booking procedure without any mistakes.

MET 2020 Slot booking Guidelines

Candidates are advised to visit the official website - manipal.edu. To check the demo of the slot booking process for the Manipal Entrance Test 2020 candidates is advised to click on the link provided below.

MET Slot Booking Demo Direct Link

According to the notification available on the official website the MET 2020 examination is scheduled to be conducted in the decided number of cities and all the applications will be able to book their entrance test slots via the Online Test Booking System (OTBS) based on the availability of the seats. It must also be noted that in case a low number of applicants are seen in a particular city, the test centre will be shifted to the nearest city which is available on the OTBS.

The list of cities in each state where the Manipal Entrance Test 2020 will be conducted is available on the official website of MET. Candidates can also check the list of cities through the direct link provided below.

MET 2020 List of cities Direct Link

Manipal Academy of Higher Education conducts the Manipal Entrance Test 2020 for the admissions to the BTech, BTech (Lateral Entry Admissions), BPharm / PharmD, MTech, ME, MPharm / PharmD Post Baccalaureate, MSc Medical Biotechnology, MSc Molecular Biology & Human Genetics, MSc Systems Biology, MSc Genome Engineering, MSc by Research in Life Sciences programmes offered by the university.

Also Read: APSCHE to begin online GATE 2020 sessions for students during COVID-19 lockdown from today onwards

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From blood clots to ‘Covid toe’: Experts confounded by series of medical mysteries – The Straits Times

Posted: at 11:43 am

LONDON When the first cases of a new coronavirus started to appear in China last December, the disease seemed to be a particularly aggressive respiratory infection. An "urgent notice" that month from the Wuhan health commission warned of "successive cases of unknown pneumonia".

Respiratory symptoms are still the first signs that doctors look for in suspected Covid-19 cases: cough, shortness of breath and fever.

But, less than five months after it was first identified, this new coronavirus is managing to throw up a series of medical mysteries - from blood clots and strokes to digestive problems - that are confounding the scientific community.

From head to foot, Covid-19 causes a fiendish variety of symptoms. Some are relatively mild, such as loss of smell and taste or chilblain-like sores on toes. But others may be fatal, such as when what doctors call an immune storm destroys vital organs. The more this virus is studied, the more complex it appears to be. "Every day we're learning of new tricks that the virus plays," Imperial College London's professor of experimental medicine Peter Openshaw says. "It is remarkable to see a disease unfolding in front of our eyes with so many twists and turns."

The proliferation of complex symptoms is not just a challenge for doctors treating the disease, but also for health systems trying to adapt to the pandemic. In the early months, the focus was on getting hold of ventilators that could help patients with severe respiratory problems. But now hospitals are also scrambling for more kidney dialysis machines and anticoagulant drugs.

A single individual can suffer the disease in more than one form, Prof Openshaw adds. "There are accounts of people experiencing one symptom, for example coughing, appearing to recover or go into remission and then returning with a more serious systemic disease."

With the worldwide death toll from Covid-19 already nearing 260,000 and confirmed cases close to exceeding 3.7 million, according to Johns Hopkins University, scientists have mobilised at a speed and on a scale unprecedented in the history of medicine, in an effort to understand the myriad ways in which the virus affects the human body. They hope that their research will not only improve clinical care of patients but also help the development of drugs and vaccines.

The initial diagnosis was that it was a respiratory infection, like its sister diseases Sars and Mers which are also caused by coronaviruses.

Respiratory symptoms remain the most common manifestations of Covid-19 in patients who go to hospital, according to a study of almost 17,000 people admitted to 166 UK hospitals carried out by a research consortium from Imperial College and Liverpool and Edinburgh universities. About two-thirds of patients in the study - the largest of Covid-19 hospital patients outside China - were admitted suffering from respiratory symptoms, says Dr Annemarie Docherty of Edinburgh, the lead author of the paper. But that proportion may have been raised by the fact that they reflect the official case definition of Covid-19.

But two other clusters of symptoms also dominate hospital admissions: systemic musculoskeletal symptoms (muscle and joint pain and fatigue) and enteric symptoms (abdominal pain, vomiting and diarrhoea). Many patients suffer from several symptoms simultaneously.

How the immune system reacts to Covid-19 is key to the course of the disease in adults. People who have been suffering with mild to moderate symptoms for a week or so often seem to hit a critical point: usually their immune system gets the virus under full control and sets them on a path to full recovery - but sometimes it goes into overdrive, triggering systemic inflammation and in severe cases a "cytokine storm" that destroys tissues and whole organs.

Inflammation also helps to explain why obesity makes people more susceptible to severe Covid-19. Seventy-three per cent of coronavirus patients in UK intensive care units are overweight or obese, with a body mass index above 25. "Fat cells secrete chemicals that increase the body's inflammatory response," says Liverpool University's professor of child health Calum Semple.

Kidney damage has emerged as another of the most frequent serious consequences of Covid-19, with 23 per cent of patients in intensive care requiring renal support. As with other organs, it is uncertain to what extent the virus is directly attacking the kidneys or whether the harm results more from generalised overactivity of the immune system and consequent changes in the patient's blood circulation.

Cardiovascular disease is the most common pre-existing health condition in people who die of Covid-19, ahead of lung and respiratory disorders such as asthma and chronic obstructive pulmonary disease. And many patients without a previous history of heart trouble develop severe cardiac symptoms while they are in hospital.

"When we first heard about the coronavirus we expected people with lung and breathing problems to be most at risk but that has not been the case," says the British Heart Foundation's medical director Nilesh Samani. "We need to understand why the virus is causing so many problems outside the lungs - and cardiovascular complications in particular."

The exaggerated immune response to the virus sometimes causes abnormal blood clotting. If this thrombosis happens in the brain, it may trigger a stroke. Neurologists at University College London (UCL) studied six Covid-19 patients who suffered acute stroke as a result of a large arterial blockage - in five of the cases more than a week after suffering headache, cough and fever and in one patient before other symptoms appeared.

The UCL researchers found all six patients had markedly raised blood levels of a protein fragment called D-dimer associated with abnormal clotting. The findings suggest that early testing for D-dimer could enable doctors to prescribe blood-thinning drugs to people at risk, reducing the chance of stroke or harmful clotting elsewhere in the body. "Early use of anticoagulant drugs might be helpful but this needs to be balanced against their brain bleeding risk," says study leader David Werring.

STRAITS TIMES GRAPHICS

"This study is consistent with the growing evidence that people hospitalised with Covid-19 are at risk from blood clots in multiple locations: the lungs (causing pulmonary embolus), the brain (causing stroke) and the veins (causing DVT)," says professor of cardiovascular medicine Tim Chico at Sheffield University. "The risk of blood clots with Covid-19 appears to be even greater than the increased risk of blood clots seen in other severe illnesses."

The coronavirus also seems capable of attacking the brain and nervous system directly, as well as indirectly through abnormal blood clotting, though the evidence for acute symptoms of neural infection is limited. The effects may show up in the longer term as post-viral fatigue.

Neurons in the olfactory bulb, which transmits information from the nose to the brain, are apparently infected by the virus. Indeed, anosmia - loss of the sense of smell - is one of the most frequently reported symptoms of mild infection, affecting about half of patients and lasting for several weeks in some cases.

The good news for those who develop anosmia is that they are much less likely to become seriously ill with Covid-19. Dr Carol Yan and colleagues at the University of California San Diego (UCSD) reported last week that patients reporting loss of smell were 10 times less likely to be admitted to hospital for Covid-19 than those without loss of smell.

The UCSD researchers suggest that a relatively small dose of virus delivered to the upper airway, where it causes anosmia, may be less likely to overwhelm the host immune response. "This hypothesis is in essence the concept underlying live vaccinations, where low dosage and a distant site of inoculation generates an immune response without provoking a severe infection," they say.

The declining strength of the immune system with age is a partial explanation for the increasing incidence of Covid-19 in older people. PHOTO: AFP

Besides anosmia, the most frequently seen minor symptoms are rashes, pustules and blisters on the skin - including lesions like chilblains that dermatologists are calling "Covid toe".

The results from the study led by Imperial College, Liverpool and Edinburgh universities echo other findings that the disease is much more common in men - who make up 60 per cent of UK Covid-19 hospital admissions - and its severity rises markedly with advancing years (the median age of patients is 72). The strong associations with the male sex and old age are a particular feature of Covid-19 compared with other infectious illnesses.

Data from the UK Intensive Care National Audit & Research Centre shows that men make up 71.5 per cent of patients whose disease becomes severe enough to require intensive care treatment. A comparable control group of patients critically ill with non-Covid viral pneumonia was just 54.3 per cent male.

"The reason behind this difference in Covid risk is unknown," says Dr James Gill, honorary clinical lecturer at Warwick Medical School. "There are several schools of thought on the matter, from the assumption that simply men don't look after their bodies as well, with higher levels of smoking, alcohol use, obesity and other deleterious health behaviours, through to immunological variations in genders. Women may have a more aggressive immune system, meaning a greater resilience to infections."

University of Oxford's professor of immunology Philip Goulder points out that several critical immune genes are located on the X chromosome - of which women have two copies and men one. "The immune response to coronavirus is therefore amplified in females," he says.

The declining strength of the immune system with age is also a partial explanation for the increasing incidence of the disease in older people, though it is not clear why this trend is more pronounced in Covid-19 than in many other viral infections.

Children are remarkably - but not completely - resistant to the disease. Just 3 per cent of UK hospital patients are under 18. Again no one knows quite why. But one answer may lie in the "keyhole" through which coronavirus enters human cells, known as the ACE2 receptor. In children these receptors have not developed to their full adult stage and therefore may not fit the "spike protein" that the virus uses to enter cells.

It is also possible that ACE2 develops more quickly in children's upper airways than their lower respiratory tract, allowing them to become infected - and thus able to transmit Covid-19 - without showing the same progression to severe symptoms.

The National Health System in London and the UK Paediatric Intensive Care Society recently alerted doctors to a rise in the number of children suffering from "a multi-system inflammatory state" similar to toxic shock, which might result from the immune system overreacting to viral infection. Italian and US paediatricians have noticed a similar body-wide inflammatory syndrome in children.

This paediatric condition is rare but researchers are investigating, says Prof Semple. "Some respiratory viruses are associated with a systemic inflammatory response, typically two weeks after infection. But this could be a phenomenon of heightened awareness."

Research also shows that children are remarkably - but not completely - resistant to the disease. PHOTO: AFP

For Prof Openshaw, the mysteries of Covid-19 recall the early days of the HIV/Aids outbreak in the 1980s - except that this time, they are unfolding much more quickly. "We need the answers also to appear far faster than they did with HIV," he says.

A global research effort is on to discover human genetic factors that would help to explain why Covid-19 infection varies so much in its symptoms.

Although much of the variation results from environmental and lifestyle factors, scientists are convinced that genetics play a significant role too.

"Experience with other viruses shows that genetics can explain some of the different responses to infection," says Dr Mark Daly, director of the Institute for Molecular Medicine Finland in Helsinki, who is coordinating the global response through the Covid-19 Host Genetics Initiative.

For example, genetic mutations on the CCR5 protein, which HIV uses to enter human cells, make rare individuals resistant to Aids. Researchers may find comparable variations in the human ACE2 protein, entry point of the coronavirus, designated as Sars-Cov-2, that causes Covid-19.

The Covid programme has two overlapping components. One uses human genomes already obtained for other research purposes from volunteers through bodies such as UK Biobank and Genomics England - and looks for differences in DNA between participants who become ill with Covid-19 and those who do not.

The other part obtains the fresh genomes from Covid-19 patients, looking for variations that might explain why some experience only mild symptoms while others become severely ill.

Genomics England, a public body owned by the UK Department of Health and Social Care, is involved in both approaches. Dr Mark Caulfield, its chief scientist, says it is too early to have obtained any results. "But I am confident that reading whole genomes will help to identify variation that affects response to Covid-19 and to discover new therapies."

Prof Daly hopes the initiative will have tens of thousands of human genomes to analyse. "We particularly want to identify a subset of younger individuals with no comorbidities who have a severe response to Sars-Cov-2 infection," he says.

FINANCIAL TIMES

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Libertarian Party To Choose Its Presidential Ticket in Virtual Vote Over Memorial Day Weekend – Reason

Posted: at 11:37 am

The Libertarian Party's National Committee (LNC) decided by a 134 vote today, after a tortuous 8-hour Zoom meeting, to divide the party's convention business into two parts.

The first will be an online meeting over the same Memorial Day weekend during which the scotched in-person convention was supposed to occur in Austin, Texas. At this online meeting, "nomination and balloting for party candidates for President and Vice-President" will occur.

Then a follow-up physical convention will be held in Orlando, Florida, from July 812. While the LNC did not formally commit yet to a contracted venue, they received a presentation from the Rosen Shingle Creek resort that seems to be a favorite.

The realities of the pandemic led the original convention hotel to cancel the party's reservation. Some expected that last Saturday the LNC would commit to a non-physical option, but instead, they voted to give themselves another 10 days to set up an alternate physical convention to occur before July 15.

Lots of debate stormed in the week between about parliamentary, legal, and physical possibilities and impossibilities. That debate continued during today's marathon LNC meeting.

Some insisted the word "place" in the party's bylaws (Article 10), had to mean a physical place, and thus conducting official convention business online would violate those bylaws. A vast amount of time today was spent on the metaphysical question of "what is a place?" and the proper reasonable meaning of "impossible."

Others insisted that Robert's Rules of Order was making new adjustments for the pandemic reality of electronic meetings; some argued that regardless of whether some electronic meetings are allowed under Robert's, Article 12 of the party bylaws did mention that "Boards and committees may conduct business by teleconference or videoconference." Yet! Article 10 did not specify that a convention could. Some believed that notmentioning virtual specifically as possible for conventions meant such online conventions were prohibited.

Some believed that if Robert's Rules and the Libertarian Party bylaws prevented the organization from performing the very purposes that bylaws and Robert's Rules are supposed to help with (not prevent), such stringent interpretation was perverse and unnecessary. Some mocked the idea that any available physical place could possibly hold nearly 1,000 people and conduct business with safe social distancing, but Orlando's Rosen Shingle Creek thinks it can.

Some worried, during the meeting and in online chatter, that the progress of the law or the pandemic might make the party have to eventually cancel the in-person portion in July later anyway. Many also worry that the combination of the pandemic and the presidential vote having already occurred will encourage lots of would-be delegates to not show up in Orlando even if an in-person event does happen, leaving whoever wins the party officer positions (and other issues settled) at that in-person convention under a shadow moving forward.

Lots of back and forth happened today about whether it mattered much that it was merely difficult or inadvisable for people to travel to an in-person convention during a pandemic; after all, there is always somereason a delegate a state party picked might not make it to the actual convention. Some thought it made the party look criminally irresponsible to encourage 1,000 people to travel across the country to descend on a city, then scatter; some thought it made them look like they were kowtowing to tyrannical fears and supportive of shutting down American business to notdo that.

Outgoing LNC chair Nicholas Sarwark (he is not running for re-election) said in a phone interview before the meeting that he believed "the best [thing] for the party to do would be to set the national convention for Saturday and Sunday of Memorial Day weekend" (to honor the commitments of time already made by delegates), but hold it "in an online venue like Zoom, and have prepared a motion to modify the convention agenda" to move most convention business outside "LNC, judicial, presidential, and vice-presidential elections" to some later, potentially in-person convention, since most other business and motions would be difficult to do online. This is more or less what happened, though today's recommendation has LNC and judicial votes pushed to the later in-person meeting.

Daniel Hayes, head of the convention oversight committee, said in a phone interview before the meeting that an in-person convention was vital for media attention; this is likely so, though shifting the presidential vote into the virtual earlier convention likely will drain some media interest from the physical followup. Out of an abundance of caution over whether some entity might later decide the decision of a virtual presidential vote was technically against the rules, the outcome of the Memorial Day online vote will need to be ratified by the July in-person convention.

LNC Secretary Caryn Ann Harlos was one of the leading voices, at first, for an in-person convention only, but was key in offering a version of the "presidential vote electronic, rest in person later" compromise. Overarchingly, she thinks talk of evading inconvenient bylaw interpretations for whatever reason is violating the "contract with members," since she sees the bylaws as a contractual agreement the LNC has made with the party's members.

Harlos thinks, though, that since their very purpose as a party is to run national candidates, a compromise that allows that and only that business to be done electronically was acceptable, as waiting much longer would conflict with certain state's ballot access deadlines. However, she believes "merely being scared of a virus" was not a good enough reason to mess around with the bylaws' clear language.

The LNC has been experimenting this week with Zoom meetings that emulate the functions of a normal convention, though some participants have found them lacking, subject to both technical glitches and giving presiding officers more power to control how delegates can communicate than in an in-person meeting.

The LNC doesn't have the power to tell the actual delegates assembled that they can only do specific things at a convention, so the choice to only do the presidential vote at whatever electronic meeting commences will ultimately have to be made by the convention body itself.

Rep. Justin Amash (LMich.), the newly minted Libertarian congressman who is certainly a frontrunner, if not now the frontrunner, for the party's presidential nomination said in an interview with The Fifth Column podcast this week (starring Reason's Matt Welch) that "For my partI want every candidate to feel that they got a fair shot, including our campaign. We all want to be treated fairly under this process and that's what's important, that nobody feels like this was some kind of a setup one way or the other either for my candidacy, or against my candidacy, and every other candidate feels the same way about their own campaign." Amash added, "I think it's important that we not postpone it too late because if you postpone it too long, it makes the calendar more challenging and we want to make sure we get on the ballot in all these states too.A campaign has to get up and running and it would be better if it doesn't go all the way to July or something like that."

The matter is important because some state ballot petitioning rules require the actual named candidate, so the later the candidate is named, the harder it will be to meet those requirements. Candidate Jim Gray, former California Superior Court judge and former Libertarian vice presidential candidate in 2012, said in a phone interview this week that while it "would be much more preferable to have an in-person convention, for our campaign, for the party, for the country, since there will be less excitement and less give and take [likely online]having said that, it's a tradeoff." If waiting for a reasonably safe and doable face-to-face meeting "would likely result in us losing ballot access in too many states," then he understands.

Joe Bishop-Henchman, a candidate for LNC chair this year and a leader in the "online presidential vote" faction said in a phone interview before the convention that he worried if the party didn't settle its presidential candidate question sooner rather than later that some state party affiliates might see it necessary to "defy [the national party] and go it alone." In that case, he would not "hold it against them," but he thinks the compromise reached today will "prevent that from happening, the danger of different presidential tickets in different states."

While this question was not settled, many on the LNC seemed to think that if certain state delegations were prohibited by their own state's travel restrictions from making it to Orlando, some allowance would likely be made by the delegates at that convention to allow them to participate in votes and debates virtually.

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Johnson address shows he has been swayed by hawks in his cabinet – The Guardian

Posted: at 11:37 am

Boris Johnson famously dislikes disappointing the people around him.

The result is this weekends barrage of confused messaging over whether the lockdown is ending, as he tries to please both sides in the battle raging within the Tory party about how to respond to the coronavirus crisis.

On the one hand, the rightwing hawks in his cabinet have been pushing him towards a swift return to business as usual to save the economy, setting out a roadmap to lifting the lockdown sooner rather than later. On the other, the more centrist doves, including the health secretary, Matt Hancock, have been pulling him in another direction, urging caution for fear of a second peak and more lost lives.

The received wisdom is that Johnson is now on the side of the doves following his brush with death during a four-day spell in intensive care suffering from Covid-19.

The start of his address on Sunday was cautious: he insisted that there was no immediate end to the lockdown and would allow only a gradual shift to unlimited exercise within household groups from Wednesday.

However, his overall shift in tone, ditching the stay at home message in favour of a stay alert slogan, told a different story. That new message appears designed to appease some of his critics within the Conservatives mostly on the Brexit-backing libertarian right of the party, who want to see more emphasis on people being trusted to take their own decisions about risk.

The decision to set out an ambition to reopen schools and some shops in June and some hospitality venues in July without the epidemic in care homes and hospitals yet under control also shows he has also been swayed by the hawks in his cabinet.

And a renewed emphasis on asking people to get back to work, even if they cannot observe social distancing, is another move that will please Tory MPs worried about the furlough scheme while alarming trade unions concerned about the safety of their workforces.

It is clear from the scathing reaction of Nicola Sturgeon, the first minister of Scotland, that there are serious worries in the devolved administrations about the risk of lifting the lockdown too soon and the chaotic messaging that is accompanying it.

Supporters of Johnson argue that he is trying to strike a careful balance between setting out a roadmap for reopening the economy and making no promises about exactly when schools, shops, cafes and restaurants would reopen.

He insisted that the government would ultimately be driven not by mere hope or economic necessity, [but] [by] the science, the data and public health.

However, sooner or later Johnson is going to have to pick a side in the argument over whether the threat of a crashing economy requires taking some risks with public health unless the epidemic starts to clear more quickly than scientists anticipate.

And in the meantime, the public has been left with some of the biggest questions unanswered especially about when they will be able to freely see their family and friends again.

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Dershowitz Defends and Criticizes Flynn by Railing Against Entrapment and Fair-Weather Civil Libertarians – Law & Crime

Posted: at 11:37 am

Harvard Law Professor Emeritus Alan Dershowitz came out fighting for Michael Flynn in a column published early Friday morning by the conservative think tank the Gatestone Institute.

Titled: Flynn Was Innocent All Along: He Was Pressured to Plead Guilty, Dershowitz reiterates his longstanding belief that the former lieutenant general and national security advisor should never have pleaded guilty because he did not commit a crime.

Per the largely pro-Flynn piece (emphasis in original):

For a lie to be a crime under federal law, it must be material to the investigation meaning that the lies pertain to the issues being legitimately investigated. The role of the FBI is to investigate past crimes, not to create new ones. Because the FBI investigators already knew the answer to the question they asked himwhether he had spoken to the Russian Ambassadortheir purpose was not to elicit new information relevant to their investigation, but rather to spring a perjury trap on him. When they asked Flynn the question, they had a recording of his conversation with the Russian, of which he was presumably unaware. So his answer was not material to the investigation because they already had the information about which they were inquiring.

This territory is well-trod for the famous legal analyst.

Dershowitz was roundly criticized on Twitter in late 2018 after telling Fox News that lying to the FBI is not a crime.

I hope the judge understands when he has the case tomorrow that Flynn did not commit a crime by lying, Dershowitz told Bill Hemmer at the time. Because the lie has to be material to the investigation. And if the FBI already knew the answer to the question and only asked him the question in order to give him an opportunity to lie, his answereven if falsewas not material to the investigation.

Earlier this year, and well after a high-profile defense team shakeup, Flynns attorney Sidney Powell appeared to repay the public attention paid to her client by approvingly paraphrasing Dershowitz in a bid for probation.

Still, Dershowitzs column also calls Flynn out for hypocrisy:

There must be a single standard of justice and civil liberties including the presumption of innocence that transcends partisan politics. This message has been forgotten by both parties. Flynn himself was among those who shouted, Lock her up, regarding Hillary Clinton. Then when the Justice Department tried to lock him up, he got religion.

But Mondays column doesnt hone in too deeply on the details of Flynns case. Rather, Dershowitz appears to mainly be using Flynn as a cautionary tale to explain his perspective on law enforcement excess and the value of consistently prizing civil liberties.

Some may wonder why an innocent man would ever plead guilty, Dershowitz tees. Anyone who knows how the system works in practice would understand why an innocent manor a defendant in a close casemight be coerced into pleading guilty. The cruel reality is that if a defendant pleads not guilty and is found guilty, the sentence will be far greater than if he had pled guiltyperhaps even 10 times greater.

These are the kinds of pressures routinely used by prosecutors, the column continues. Civil libertarians have long been critical of these pressures, but fair-weather civil libertarians refuse to object when these improper tactics are used against Trumps associates. Partisan hypocrisy reigns.

The points raised in the column are particularly salient for criminal defendants in the country that locks more people up per capita than any other country. Over all, there are now more people under correctional supervision in Americamore than six millionthan were in the Gulag under Stalin at its height, The New Yorkers Adam Gopnik noted in 2012.

Law&Crime asked Dershowitz if he thought police routinely over-charge and if his admonishment for federal law enforcement to stop creating crimes bears any applicability to the overall criminal justice system.

To which he replied: Yes and yes.

[image via screengrab/ The View]

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Analysis: Reeves tries to balance concerns of health, jobs – Associated Press

Posted: at 11:37 am

JACKSON, Miss (AP) Mississippi Republican Gov. Tate Reeves is having to balance his libertarian-leaning instincts with public health concerns during the coronavirus pandemic.

Its been his job the past several weeks to order some businesses to temporarily close and to restrict peoples face-to-face interactions to try to slow the spread of the highly contagious virus. His statewide shelter in place order remains in effect until May 25.

Reeves is gradually letting businesses reopen even as numbers of confirmed COVID-19 cases and deaths continue to rise.

Restaurants could start serving food and drinks their dining rooms and patios Thursday, after more than a month of being limited to carry-out service or deliveries. Barbershops, beauty salons and gyms are allowed to start reopening Monday. They all must meet safety standards such as limiting customers and taking extra steps for sanitation.

The governor has said repeatedly that people should use their own best judgment.

If you are in the vulnerable category, if you are over the age of 65, if you have pre-existing conditions, getting out of your home has risks, Reeves said Friday. Going to a salon has risks, but were trying to put measures in place to minimize those risks. We recognize also that the spread of the virus has risks. The spread of the economic collapse has risks.

Reeves spent eight years as state treasurer and eight as lieutenant governor before being inaugurated as governor in January. He has consistently advocated a limited role for state government. Legislators cut several thousand jobs from the state government workforce when Reeves had a big role in writing budgets as lieutenant governor.

Fairly early in the pandemic, Reeves said hes concerned about people facing abject poverty because of job losses. Its a phrase he has not often used in speeches or interviews during 16-plus years of serving in public office in a state that has been one of the poorest in the U.S. for generations. During news conferences about COVID-19, Reeves often mentions people who are having to file unemployment claims for the first time in their lives.

The governor says his top adviser during the pandemic is the state health officer, Dr. Thomas Dobbs. He is also listening to business executives and to people who express concerns about the economy.

Reeves frequently says that restarting Mississippis economy is not like flipping a light switch from off to on but like using a dimmer switch to go from dull to bright.

He emphasizes the role of personal responsibility, saying that people should mostly remain home and that they should wear masks in public, keep distance between themselves and others and avoid taking the whole family to the grocery store if possible.

If we do not want to return where we were several weeks ago, with more businesses closed and more shelter-in-place I have to ultimately make that decision, Reeves said last week. But the thing is, the people of Mississippi can make that decision first if the people of our state will be smart, if theyll stay safe.

Reeves said city and county law enforcement officers have done a fantastic job of enforcing safety orders during the pandemic, and state law enforcement officers are available to help them. As more businesses reopen, Reeves said the best enforcement of safety standards will come from within.

The number one person that it is going to enforce this is the person that is actually opening the business. Its the employees. Its Mississippians. Its people who care about not only themselves, but about their fellow man, Reeves said. I am convinced that the industries that we are reopening are going to do a better job of monitoring it themselves than any governmental entity ever will.

____

Emily Wagster Pettus has covered Mississippi government and politics since 1994. Follow her on Twitter: http://twitter.com/EWagsterPettus.

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Originalism, Common-Good Originalism, and Common-Good Constitutionalism – Reason

Posted: at 11:37 am

Last month, Adrian Vermeule wrote an essay titledBeyond Originalism. The Harvard Law Professor contended that originalism had already served its purpose, and our polity should shift to what he called "common-good constitutionalism." Co-blogger Randy Barnett responded to Adrian, and warned about the risks of any non-originalist approach to the Constitution.

Last week, my friend Josh Hammer wrote another reply to Vermeule that seeks to stake out something of a half-way position. He calls it "common good originalism." Here is a snippetthough I encourage you to read the entire essay.

Common good originalism should adopt the conservatism of Hamilton, Marshall, and Justice Joseph Story as its jurisprudential lodestar. The interstices naturally permitted by a more expansive constructionism will, assuredly, provide ample room for jurists to deploy substantive moral argumentation along the lines favored by scholars like Jaffa and Arkes. Furthermore, by rejecting hyper-literalist free speech absolutism, common good originalism permits (within reason) natural law-undergirded arguments about the moral worth of one's speech, such as Alito's dissent inSnyder: "Our profound national commitment to free and open debate is not a license for the vicious verbal assault that occurred in this case."

Common good originalism also rejects natural law-subversive "originalist" claims aboutconstitutionally mandated marriage redefinitionthat would undermine the common good, risible anti-sovereigntist "textualism" claims aboutconstitutionally mandated open bordersthat would wreak havoc upon the common good, and so forth.

This is only a bare-bones beginning. And I know, of course, that I will not persuade Vermeule himself. But my aim is to lay out a framework upon which to build an assertive, moralistic, Burkean/Hamiltonian conservative jurisprudence. This jurisprudence is also legitimate, from a positive law perspective, because it is rooted in (an expansive construction of) the constitutional text and thereby avoids the "oath-breaking problem" posed by Article VI of the Constitution.

Vermeule has now responded to Hammer.

JoshHammer has written a characteristically thoughtful and engaging response toCommon-Good Constitutionalism, arguing for an approach he calls "Common-Good Originalism." I see Hammer's approach as a laudable development, a movement half-way to the right approach. But as with many half-way positions, it is unstable. The structure built of originalism and the common good fits together poorly, for the former is a positivist approach and the latter a nonpositivist one. Thus nothing at all guarantees that the original understanding will necessarily or even predictably track the common good (however the latter is defined), and conversely it is always possible, indeed likely, that the common good (however defined) will prescribe an interpretation that cannot be justified in originalist terms.

Adrian adds that Hammer's position may become something of a middle-ground:

To be sure, even if originalism and the common good cannot be combined in a stable manner, a house with shaky foundations may happen to be shored up by external buttressing. I wouldn't be wholly shocked to see a position like Hammer's become a new political equilibrium, one that supersedes the currently reigning libertarian originalism, and theoretical coherence be damned. But that contingent political dimension is not my concern here. My point is one of theory: common-good originalism, whatever its political appeal, has an inherent tendency to break down into one or another of two distinct views, one which subordinates the common good to originalism, and the other which subordinates originalism to the common good.

And Adrian praises Hammer's non-libertarian approach to originalism:

There is much to admire in Hammer's argument. It is a long step away from the libertarian form of originalism that has colonized the legal right at least since the second Bush administration, and that until recently dominated the scene. Justice Scalia'smodus operandi (viewed from the outside; I do not suggest that this was a deliberate strategy) was to stake out a principled position, resting on internally coherent arguments, that would expand the range of the thinkable on the Court, and then to watch his colleagues struggle part-way towards his views with positions that were uneasy compromises. In that Scalian sense, Hammer's piece,internally conflicted though it may be, amounts to an ominous sign of the times for conventional originalists. When a prominent young conservative commentator like Hammer expressly rejects "pure legal positivism and the elevation of procedure to the complete detriment of substance, most frequently associated with the jurisprudences of the late Judge Robert Bork and the late Justice Antonin Scalia," one can almost feel the winds of change freshening.

We are watching an important debate play out in front of our eyes. And the stakes are high. In the past, I have described the "libertarian" wing of the FedSoc legal movement as "ascendant." I still think that is the case, but there is movement afoot. Contrary to left-wing caricatures, we are not monolithic lemmings. There are some common grounds of agreement, and there are other areas of sharp disagreement. Randy wrote about this shift:

In particular, I have sensed a disturbance in the originalist force by a few, mostly younger, socially conservative scholars and activists. They are disappointed in the results they are getting from a "conservative" judiciarynever mind that there are not yet five consistently originalist justices.Someattribute this failing to originalism's having been hijacked by libertarians. Some have been drawn to the new "national conservatism" initiative, which makes bashing libertarians a major theme. These now-marginalized scholars and activists will be delighted to fall in behind the Templar flag of a Harvard Law professor like Vermeule.

Josh Hammer makes this point expressly, and ties it to a current case:

Within this broader context of conservatives reconsidering orthodoxies, Vermeule's proposal fits quite neatly. What Georgetown University Law Center Professor Randy Barnett calls a "disturbance in the originalist force by a few, mostly younger, socially conservative scholars and activists" could evolve into amore thorough exodusaway from originalism if, as is heavily rumored, putative originalist Justice Neil Gorsuch sides with his progressive colleaguesthis termby reading into Title VII legal protection thebiological and linguistic liethat is "transgenderism."

I agree with Josh Hammer that Adrian has shifted the Overton window. This issue warrants far more discussion.

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Adele: Three Secrets Behind Her Incredible Weight-Loss – Longevity LIVE

Posted: at 11:16 am

Adele is a global superstar, with her amazing voice earning her an Oscar, 15 Grammys as well as multiple world records. Its clear that shes a successful woman, and we all know it. However, the soulful singer has been making headlines lately, not because of her unmatchable talent, but because of her visible weight loss.

Her weight loss was first noticed last year at musicians Drakes birthday bash on October 25 but its her most recent social media post that has got fans talking. Making her first Instagram post of 2020 where she thanked essential workers during the coronavirus pandemic as well as gave thanks for her birthday well wishes, fans were surprised at her weight loss. In the past, Adele once revealed to People Magazine that shed refuse to work with anybody who had an issue with her weight, stating: Even when I was signing a contract, most of the industry knew if anyone ever dared say: Lose weight to me, they wouldnt be working with me.

Adele has yet to publicly discuss her weight loss, and she really has no reason to. The fact of the matter is, Adele is a beautiful and talented woman, regardless of how she looks and what she weighs. Her weight loss pales in comparison to the other incredible things that shes achieved in her young life, and it really shouldnt be framed as the most incredible thing shes done in recent memory. That said, for those on a weight loss journey, they are curious as to how the star did it.

In addition to her incredible figure, fans also noticed that the singers face also looked a little different.

As a result of her weight loss, Adele has lost volume and fat in her face. As a result, her features have become more prominent with her jaw and bone structure appearing sharper and more chiseled. Additionally, its clear that she changed up her diet as she appears to have a much healthier glow. The fact is, your skin is what you eat and when you consume a nutrient-dense diet rich anti-oxidants, your skin will definitely thank you for it.

The seventh most Googled diet in 2019, its clear thats theres some buzz surrounding The Sirtfood diet, and with Adeles weight loss, the buzz is certain to grow.

The Sirtfood diet was created in the United Kingdom by nutritionists Aidan Goggins and Glen Matten, after they published a guide and a recipe book in 2016. The diet focuses on sirtuins, a group of seven proteins found in your body that help to regulate a variety of functions, which include preventing cell death, regulating metabolism, inflammation, as well as the aging process. The diet requires one to consume foods rich in sirtuins, known as sirtfoods, in an effort to activate the sirtuins that will boost fat burn and speed up metabolism.

As mentioned, the Sirtfood Diet encourages the consumption of foods that contain Sirtuins. These Sirtfoods are nutrient-dense and healthy to eat regularly. They include:

Photo by Jim Smeal/Shutterstock (8344889me)Adele59th Annual Grammy Awards, Arrivals, Los Angeles, USA 12 Feb 2017

The diet is broken down into two phases, and if you should do it whenever you feel that you need a bit of a weight-loss boost.

This phase lasts for seven days and its also split up. For the first three days, youre limited to a total of 1000 calories a day. Your diet consists of three Sirtfood green juices (containing kale, arugula, parsley, celery, green apple, lemon juice, and green tea) and one Sirtfood-rich meal. A mean can include miso-glazed tofu, the Sirtfood omelet, or a shrimp stir-fry with buckwheat noodles.

On days four through seven, youll then allowed two green juices and two daily meals for a total of 1,500 calories a day.

Phase one is aimed at jump-starting your weight loss (apparently, youre expected to lose 7 pounds during phase one). The diet does recommend that you stop exercising, or at least cut back on your usual fitness routine during this period as you wont be taking in many calories.

The second phase lasts for two weeks and it is known as the maintenance phase. Its purpose is to encourage weight loss in a steady, sustainable, and manageable way.

There is no calorie limit but you are encouraged to eat three balanced meals that are rich in Sirtfoods, as well as drink one green juice, during this phase. The meal recipes include soy yogurt with berries and stir-fried prawns with kale and buckwheat noodles.

Once youre done with the phases, you can continue with the Sirtfood diet, all you have to do is tweak your meals a bit, and include as many Sirtfoods as possible. Additionally, once youve adopted the Sirtfood lifestyle, youre encouraged to stay active.

Considering the fact that youre consuming way fewer calories than usual, yes, youll probably lose weight adopting this diet. However, whether this particular method is healthy is debatable. This is because super-restrictive eating is rarely healthy or sustainable.

If you consider the fact that 1,000 calories per day is only appropriate for a child between the ages of 2 and 4, I wouldnt exactly call this diet plan healthy. Yes, the diet may enable weight-loss, but living on this kind of calorie restriction for too long would be questionable.

Yes, theres no denying that the foods in the Sirtfood diet are good for you. Plenty of research has shown that green tea, turmeric and even dark chocolate can provide the body with a number of health benefits that include reduced risks of heart disease, diabetes and other inflammation-related diseases. However, actual research into the long-term benefits of increased sirtuin levels in humans is still in its early stages. Additionally, calorie restriction is not how you want to be living your life.

Yes, Adele looks amazing but if she is following the Sirtfood diet, shes more than likely tweaked it in a manner that is sustainable and safer for her health. That said, its advisable that you reach out to a certified dietitian and get their thoughts. Our bodies are each different, and adopting this particular diet does not mean that youll get Adele-results.

According to the Daily Mail, the singer has taken up Reformer Pilates after being introduced to it by close friend Ayda Field, X Factor judge and wife of singer Robbie Williams.

We already know that Pilates is a great exercise for the body, and the same can be said for Reformer Pilates. Reformer Pilates is a more technical version of regular Pilates, requiring practitioners to do Pilates moves on special machines, using ropes, springs, and a carriage. The exercises provide a high intensity yet low-impact full-body workout. Reformer Pilates helps to improve posture, strength, and flexibility as well as build a stronger core and tone your muscles.

Adele has never shied away from being herself and being confident in her skin. While the star is known for her heart-wrenching ballads, its clear that self-love is a huge priority of hers. Last year, Adele celebrated her 31st birthday, and she shared an Instagram post that hinted at prioritizing self-love.

For the first time in a decade, Im ready to feel the world around me and look up for once. Be kind to yourself, people, were only human, go slow, put your phone down and laugh out loud at every opportunity, she shared. Learning to REALLY truly love yourself is it, and Ive only just realized that that is more than enough.

It may hard to do, especially during these times, but self-love can do wonders for your health. Aside from making you happier, research published in the Health Psychology journal found that self-love can help you make better decisions about your health.

Whats more, a separate study published in the Psychological Science journal found that recently divorced individuals who were kinder to themselves were better at bouncing back in the months following the separation than those who regularly self-criticized. Considering the fact that the award-winning singer is currently going through a divorce, its safe to say that shes definitely practicing a lot of self-love.

He, Y.; Yue, Y.; Zheng, X.; Zhang, K.; Chen, S.; Du, Z. (2015). Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?Molecules.20, 9183-9213.

J Clin Hypertens(Greenwich).2014;16:101106. DOI:10.1111/jch.12223.

Shuang, Z., Xiaoqiang, T., Hou-Zao C. (2018). Sirtuins and Insulin Resistance. Frontiers in Endocrinology. 9. https://www.frontiersin.org/article/10.3389/fendo.2018.00748

Sirois, F. M., Kitner, R., & Hirsch, J. K. (2015). Self-compassion, affect, and health-promoting behaviors.Health Psychology, 34(6), 661669.https://doi.org/10.1037/hea0000158

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Human touch is essential. How are people coping with skin hunger? – The World

Posted: at 11:16 am

Dont touch your face."Avoid hugging." Stand 6feet apart."

So many rules about preventing the spread of the coronavirus warn against touching other people. For the last two months, grandparents have been advised against holding their grandchildren while sick patients cannot grasp a relatives hand.

What kind of effect does this lack of human touch haveon people?

Related:COVID-19 interrupts fertility plans for hopeful couples in the United Kingdom

Amanda Whitlock, 39, a photo editor in Chicago, describes herself as a natural introvert. She lives on her own, with her cat Mr. B, and a newly adopted kitten and says shes usually very content in her own company. Whitlock went into a self-imposed lockdown in early March and hasnt had any physical contact with another person since. She says its all starting to get to her.

"I'm someone that has anxiety anyway. The last few days, I think it's really been pretty heavy on me. You know, it would be nice to be able to go out and hang out with someone and hold their hand. You know, something as simple as that, she said.

Theres a good reason why Whitlocks anxiety is on the rise. Studies show physical contact with other people reduces feelings of stress. British evolutionary psychologist and professor Robin Dunbar says it can all be traced back to our monkey ancestry. Grooming each others fur is how apes build friendships. Humans have substituted that grooming with stroking and cuddling, he says and that act of physical touch has a profound effect on our health.

Related:Mourning in the midst of a pandemic

Not only does [touch]build friendships directly and indirectly, but those friendships have a dramatic effect on your well-being, your general health, your ability to recover from illnesses and even your longevity.

"Not only does it build friendships directly and indirectly, but those friendships have a dramatic effect on your well-being, your general health, your ability to recover from illnesses and even your longevity.

Its too early to tell whether the absence of human touch during the pandemic will have long-term consequences. Some groups are particularly vulnerable, like older people living alone, Dunbar says. Playwright Eve Ensler, who now goes by the name V, is worried about how the virus is changing the way we view our bodies. She fears that people are linking human touch with illness.

I think there's something about going out and seeing people being afraid of each other and afraid of each other's bodies.Touch is becoming something equated with sickness and death, and that scares me deeply."

I think there's something about going out and seeing people being afraid of each other and afraid of each other's bodies.Touch is becoming something equated with sickness and death, and that scares me deeply, she said.

The pandemic reminds V of the 1980s when the AIDS virus first became known. Fear of contracting HIV changed attitudes toward sex, and she worries the coronavirus will alter our behavior, too.

[AIDS] definitely changed our relationship to sex and to freedom.Drastically. I so don't want COVID-19 to do this to our relationship to touch. That would be a huge loss for human beings, she said.

Sexual intimacy is off the tablefor many people right now. But for some in the sex industry, its business as usual. Charlotte Rose, an advocate for sex workers in Britain,says many in the industry are still working because theyre not entitled to government support.

There is a large percentage that are still working because they can't claim benefits.A lot of sex workers especially migrant sex workers arent eligible either. So, unfortunately, people are still offering skin-on-skin contact.

Rose used to work in the industry and many of her clients had disabilities. She says for them, it was often not just about sex, but about simple physical contact with another person.

For probably about 90% of my clients,it wasn't even about the intercourse side of it, it was just skin-on-skin contact.I mean, I was predominantly seeing people with disabilities. And, you know, they're already a very marginalized and vulnerable group, and they're the ones that are suffering incredibly at this particular time, she said.

Rose has maintained contact with some of those clients and says a number of them are really struggling with social isolation right now.

Related:Many people arent putting love on hold during COVID-19

Sports and remedial massage therapist Ruth McKinnon knows the importance of human touch in her work, too. Originally from Toronto, McKinnon moved to London in 2017 and began working as a registered massage therapist in the citys financial district.

While many of her clients had physical injuries, McKinnon says theres no question that stress is what brought a lot of people to her clinic. A massage fires up the dopamine in the brain, helping you to relax and ultimately sleep better, she says. But McKinnon hasnt been able to work since mid-Marchwhen the British government announced that all clinics must close because of the pandemic.

McKinnon says shes feeling the effect of the lack of physical contact, too.

Even for myself, not having that regular touch with lots of different people is hard. My husband has noticed an increased amount of touching that I'm doing with him. It's so vital, she said.

McKinnon has no idea when her clinic will open again, but is hopeful she will be able to get back to work soon even if it means wearing protective clothing.

In the meantime, its not all gloom. There are some things you can do to ease the skin hunger you may be feeling. Professor Dunbar says connecting with someone over Skype or Zoom doesnt compare to a good hug but it helps. He jokes that its probably why we have these enormous great white eyeballs."

Theres something about being able to stare into the whites of other people's eyes that seems to be really important in creating that sense of intimacy. On Skype, you stare into the eyeballs and you can see the smile breaking on their face before you even finish the punchline of the joke you're telling them, he said.

In Chicago, Whitlock has been FaceTiming a man she met through a mutual friend. They havent been on a real-life date yet. This week, theyre planning to act out Shakespeares "The Tempest" together on FaceTime. But Whitlock says she longs for the day they can meet in person.

I would love to be able to text him and be like, Hey, let's meet up. Or, you know, since we can't really go anywhere, lets find a safe way in one of our places to meet. That would be awesome, she said.

But Whitlock says she doesnt think its going to happen anytime soon. For now, its just Mr. B and SP, her two cats that are keeping her company.

I think that if I didn't have my pets they're my family. If I didn't have them, I would definitely be climbing the walls right now for some human contact.

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