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Sun Pharma Announces Long-term Insights into the Clinical Use of ILUMYA(TM) (tildrakizumab-asmn) in a Cross Section of People Living with…
Posted: June 17, 2020 at 1:58 am
MUMBAI, India and PRINCETON, N.J., June 12, 2020 /PRNewswire/ -- Sun Pharmaceutical Industries Ltd. (Reuters: SUN.BO, Bloomberg: SUNP IN, NSE: SUNPHARMA, BSE: 524715, "Sun Pharma" including its subsidiaries and/or associate companies) today announced that one of its wholly owned subsidiaries presented further evidence of the long-term use and cost-effectiveness of ILUMYATM (tildrakizumab-asmn) in moderate-to-severe plaque psoriasis at the American Academy of Dermatology (AAD) Virtual Meeting Experience 2020.
Click to Tweet#NEWS: @SunPharma_Live announces long-term evidence offering insights into the clinical use of a treatment option in a cross section of people with moderate-to-severe plaque psoriasis. Read more: bit.ly/36VsmDI#AADVMX2020
Long-term analyses of the reSURFACE 1 and 2 extension studies found that ILUMYA offers sustained and improved results in patients with moderate-to-severe plaque psoriasis who received treatment for up to four years with no new safety concerns recorded.1,2 Furthermore, the safety profile of ILUMYA was reconfirmed in a five-year analysis that demonstrated low and similar exposure-adjusted incidence rates of malignancies from year four to year five. A majority of malignancies were singular events with similar incidence rates as seen in the general US population.3
Another post-hoc analysis of 335 patients who were predominately bio nave showed that those who achieved PASI 50 or higher after 6 months of treatment with ILUMYA saw continued improvement and sustained response rates when they maintained treatment for up to three years. Those patients who achieved PASI 90 at week 28 had rapid improvements as early as week 4.4
Mean Percent Change from Baseline PASI Score Over Time
Week 28 (n)
Week 52 (n)
Week 148 (n)
PASI 50-74 at Week 28
64.4% (34)
79.4% (34)
81.4% (22)
PASI 75-89 at Week 28
83.5% (79)
83.8% (78)
94.8% (63)
PASI 90-99 at Week 28
95% (131)
85.3% (131)
92.4% (117)
PASI 100 at Week 28
100% (91)
98% (90)
95.4% (81)
*95% confidence interval | Data are as observed and sample size at each study week is based on subjects with non-missing data.
ILUMYA 100 mg was well-tolerated, with a low rate of adverse events (AEs) that were comparable or numerically lower than placebo or etanercept based upon exposure-adjusted rates for many AE categories. The most common (1%) adverse reactions associated with ILUMYA are upper respiratory infections, infection site reactions, and diarrhea.
"Notably, 85 percent of the patients included in our analysis had never used a biologic before even though they have been living with psoriasis for over a decade," said lead investigator Kim Papp, M.D., Ph.D., founder and president of Probity Medical Research in Waterloo, Ontario, Canada. "This tells dermatologists that ILUMYA will treat different types of patients who have moderate-to-severe plaque psoriasis. ILUMYA is a good treatment option to consider for treatment navepatients; for patients having inadequate response to topicals or who are intolerant to or not responding well to oral treatments; and for any patient in need of a new treatment to address the chronic nature of this disease."
Six additional long-term analyses showed ILUMYA offers similar efficacy and safety results in patients with metabolic syndrome or patients who are over 65 years of age, factors that may make treatment more complex.5 6,7,8,9,10 Metabolic syndrome has a higher prevalence in patients with moderate-to-severe psoriasis compared to the overall population and an impact on response rates to many anti-TNF and IL-17 treatments.8 The analyses found that metabolic syndrome had minimal effect on the positive results seen in people treated with ILUMYA for up to three years and there was no increase in cardiac events or worsening of diabetes, compared to those without metabolic syndrome.
Furthermore, a 10-year cost analysis study revealed that ILUMYA is among the most cost-effective first-line therapies for treating moderate-to-severe plaque psoriasis and is more cost-effective than many other biologics, including risankizumab, secukinumab, guselkumab, ixekizumab, adalimumab, ustekinumab, etanercept, or certolizumab pegol.11
"It is exciting to share this wealth of clinical insights that continue to confirm the potential of ILUMYA to manage moderate-to-severe plaque psoriasis effectively and safely across different types of patients and as a cost-effective, first-line biologic treatment option," said Alan Mendelsohn, M.D., Associate Vice President, Dermatology Medical Affairs, Sun Pharma. "We are dedicated to continue bringing insights and support on the use of ILUMYA in daily clinical practice as well as exploring its potential for people living with other chronic autoimmune diseases."
ILUMYA is approved for adults with moderate-to-severe plaque psoriasis and is being evaluated for other possible uses. See ongoing studies below for more information.12,13 Visit http://www.ILUMYA.com to learn more about the ILUMYA SUPPORT Lighting the Way program that helps patients get started with treatment, understand cost and saving options, and connect with experts and others living with plaque psoriasis.
Please click here for Full Prescribing Information and Medication Guide.
Notable ILUMYA Analyses Presented at the AAD Virtual Meeting Experience 2020
The 2020 AAD Virtual Meeting Experience is accessible via registration here. *Abstract sponsored by Almirall who markets tildrakizumab-asmn in EU
About the reSURFACE Extension Studies
The Phase-3 studies (reSURFACE 1andreSURFACE 2) were randomized, placebo-controlled, multicenter, three-part studies designed to evaluate efficacy and safety of ILUMYA100 mg and 200 mg in moderate-to-severe plaque psoriasis compared to placebo and comparative drug and to assess safety and tolerability. Participants with at least 50 percent improvement in PASI 50 at base study completion who received ILUMYA within 12 weeks of base study end (week 52 or 64) were eligible to enroll in the extension study and continued on the same ILUMYA dose once every 12 weeks. Researchers evaluated PASI and PGA response (score of 0 or 1 with 2 grade reduction from baseline) and incidence rates for prespecified adverse events, including severe infections, cardiovascular events and drug-related hypersensitivities.
About ILUMYA(tildrakizumab-asmn)
ILUMYA (tildrakizumab-asmn) is a humanized lgG1/k monoclonal antibody designed to selectively bind to the p19 subunit of interleukin-23 (IL-23) and inhibit its interaction with the IL-23 receptor, leading to inhibition of the release of pro-inflammatory cytokines and chemokines. ILUMYA is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy, in the United States. ILUMYAhas also been approved for moderate-to-severe plaque psoriasis in Australia and under the brand name ILUMETRITM in Europe.
IMPORTANT SAFETY INFORMATION
ILUMYA is contraindicated in patients with a previous serious hypersensitivity reaction to tildrakizumab or to any other excipients.
Cases of angioedema and urticaria occurred in ILUMYA-treated subjects in clinical trial. If a serious hypersensitivity reaction occurs, discontinue ILUMYA immediately and initiate appropriate therapy.
ILUMYA may increase the risk of infection. Treatment with ILUMYA should not be initiated in patients with a clinically important active infection until the infection resolves or is adequately treated. Consider the risks and benefits of treatment prior to prescribing ILUMYA in patients with a chronic infection or a history of recurrent infection. Instruct patients receiving ILUMYA to seek medical help if signs or symptoms of clinically important chronic or acute infection occur. If a patient develops a clinically important or serious infection, or is not responding to standard therapy, closely monitor and discontinue ILUMYA until the infection resolves.
Evaluate patients for TB infection prior to initiating treatment with ILUMYA. Do not administer ILUMYA to patients with active TB infection. Initiate treatment of latent TB prior to administering ILUMYA. Consider anti-TB therapy prior to initiation of ILUMYA in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Patients receiving ILUMYA should be monitored closely for signs and symptoms of active TB during and after ILUMYA treatment.
Prior to initiating therapy with ILUMYA, consider completion of all age-appropriate immunizations according to current immunization guidelines. Patients treated with ILUMYA should not receive live vaccines.
Most common (1%) adverse reactions associated with ILUMYA include upper respiratory infections, injection site reactions, and diarrhea. Adverse reactions that occurred at rates less than 1% but greater than 0.1% in the ILUMYA group and at a higher rate than in the placebo group included dizziness and pain in extremity.
About Sun Dermatology
Sun Dermatology (the branded dermatology division of a wholly owned subsidiary of Sun Pharmaceutical Industries Inc.) is committed to expanding its dermatology portfolio to bring healthcare providers and patients around the world more treatment options and ongoing support for conditions like moderate-to-severe plaque psoriasis. Sun Pharmaceutical Industries Ltd., along with its subsidiaries, is ranked second in dermatology prescription volume within the U.S. per IQVIA and is the fourth largest specialty generic pharmaceutical company globally. In addition to ILUMYA, Sun Dermatology is comprised of several branded products with a focus on various dermatologic conditions.
About Sun Pharmaceutical Industries Ltd. (CIN - L24230GJ1993PLC019050)
Sun Pharma is the world's fourth largest specialty generic pharmaceutical company and India's top pharmaceutical company. A vertically integrated business and a skilled team enables it to deliver high-quality products, trusted by customers and patients in over 100 countries across the world, at affordable prices. Its global presence is supported by manufacturing facilities spread across 6 continents and approved by multiple regulatory agencies, coupled with a multi-cultural workforce comprising over 50 nationalities. Sun Pharma fosters excellence through innovation supported by strong R&D capabilities across multiple R&D centers, with investments of approximately 7% of annual revenues in R&D. For further information, please visit http://www.sunpharma.com& follow us on Twitter @SunPharma_Live.
Disclaimer
Statements in this "Document" describing the Company's objectives, projections, estimates, expectations, plans or predictions or industry conditions or events may be "forward looking statements" within the meaning of applicable securities laws and regulations. Actual results, performance or achievements could differ materially from those expressed or implied.
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Steroid Injections Improve Pain and Functionality Measures in Hand Psoriatic Dactylitis – Rheumatology Advisor
Posted: at 1:58 am
Local steroid injections are associated with clinically meaningful improvements in active dactylitis in patients with psoriatic arthritis (PsA), according to the results of a multicenter study published in Clinical Rheumatology.
Nonsteroidal anti-inflammatory drugs (NSAIDs) and local corticosteroid injections are currently recommended for the treatment of dactylitis in patients with PsA; however, there is very little information on the efficacy of local corticosteroid injections. In an observational prospective study, investigators aimed to compare the efficacy of local steroid injections and NSAIDs on the digital flexor tendon sheath for the treatment of active dactylitis in patients with PsA.
The Leeds Dactylitis Index basic (LDI-b) score was calculated at baseline, with patients rating their local pain intensity and functional impairment on 10 cm scales for each involved digit. Assessments were repeated at 1 and 3 months, postprocedure. Researchers recorded the presence of local or systemic events at each examination.
The primary objective of interest was a clinically meaningful treatment response, defined as the reduction of visual analog pain (VAS-pain) and functional impairment (VAS-FI) scores by 5 points or VAS-pain and VAS-FI scores <2. The secondary objective of interest was complete dactylitis remission (VAS-pain=0 and VAS-FI=0).
A total of 24 patients with 38 dactylic fingers were treated with steroid injections and 22 patients with 35 dactylic fingers were treated with NSAIDs. At baseline, there was no significant difference in VAS-pain score, finger circumference, or LDI-b between groups, though VAS-FI score was significantly higher in the steroid-treated group (7.871.53) than the NSAID-treated group (6.891.82; P =.018).
Significant improvements in clinical parameters were observed at 1 and 3 months in both groups; however, there were no improvements in VAS-pain scores at either time point in the NSAID-treated group. The reduction in VAS-pain (P <.001), VAS-FI (P <.001), and LDI-b values (P =.008) was greater in the steroid-treated group compared with the NSAID-treated group at 1 month. This trend continued at 3 months, post-treatment (P <.001 for all). A clinically meaningful treatment response was observed in 87% of dactylic fingers in the steroid-treated group compared with 17% in the NSAID-treated group (P <.001) at 1 month. This difference remained significant at 3 months as well. Complete remission was observed exclusively in the steroid-treated group in 1 and 7 cases at 1 and 3 months, respectively.
According to multiple regression analysis, the steroid injections were associated with a clinical response at both 1 (odds ratio [OR], 20.104; 95% CI, 2.481-162.9; P =.002) and 3 months (OR, 27.950; 95% CI, 3.227-142.1; P =.002), postprocedure.
Researchers noted that patients were given the choice to receive local steroid injections or NSAID treatment, and that the lack of randomization represented a limitation of the study. In addition, it was unclear what long-term maintenance may be needed to maintain the efficacy of steroid injections given the short duration of the study.
[T]hese data support the use of steroid injections into the digital flexor tendon sheath for psoriatic dactylitis, the researchers concluded. [L]ocal steroid injection can be recommended as a safe and effective first-line therapy for psoriatic dactylitis.
Reference
Girolimetto N, Macchioni P, Citriniti G, et al. Effectiveness of steroid injection for hand psoriatic dactylitis: results from a multicentre prospective observational study [published online May 16, 2020]. Clin Rheumatol. doi:10.1007/s10067-020-05142-z
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Steroid Injections Improve Pain and Functionality Measures in Hand Psoriatic Dactylitis - Rheumatology Advisor
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2020 Study on the Global Psoriasis Market and Competitive Landscape – ResearchAndMarkets.com – Web Hosting | Cloud Computing | Datacenter | Domain…
Posted: at 1:58 am
DUBLIN(BUSINESS WIRE)The Global Psoriasis Market and Competitive Landscape 2020 report has been added to ResearchAndMarkets.coms offering.
This research report provides comprehensive insights into the Psoriasis pipeline, epidemiology, market valuations, drug sales, market forecast, drug forecasts, and market shares. This research analyzes and forecasts the Psoriasis market size and drug sales. It also provides insights into Psoriasis epidemiology and late stage pipeline.
This research covers the following:
Psoriasis treatment options, Psoriasis late stage clinical trials pipeline, Psoriasis prevalence by countries, Psoriasis market size and forecast by countries, key market events and trends, drug sales and forecast by countries, and market shares by countries. The research scope includes the countries US, Germany, France, Italy, Spain, UK, Japan, Europe, Global (G7 Countries).
Research Scope:
Benefits of this Research:
Key Topics Covered:
1. Psoriasis Treatment Options
2. Psoriasis Pipeline Insights
2.1. Psoriasis Phase 3 Clinical Trials
2.2. Psoriasis Phase 2 Clinical Trials
2.3. Psoriasis Phase 1 Clinical Trials
3. Psoriasis Epidemiology Analysis by Countries
4. US Psoriasis Market Insights
4.1. Marketed Drugs for Psoriasis in US
4.2. US Psoriasis Market Size & Forecast
4.3. US Psoriasis Drugs Sales & Forecast
4.4. US Psoriasis Market Share Analysis
5. Germany Psoriasis Market Insights
5.1. Marketed Drugs for Psoriasis in Germany
5.2. Germany Psoriasis Market Size & Forecast
5.3. Germany Psoriasis Drugs Sales Forecast
5.4. Germany Psoriasis Market Share Analysis
6. France Psoriasis Market Insights
6.1. Marketed Drugs for Psoriasis in France
6.2. France Psoriasis Market Size & Forecast
6.3. France Psoriasis Product Sales Forecast
6.4. France Psoriasis Market Share Analysis
7. Italy Psoriasis Market Insights
7.1. Marketed Drugs for Psoriasis in Italy
7.2. Italy Psoriasis Market Size & Forecast
7.3. Italy Psoriasis Product Sales Forecast
7.4. Italy Psoriasis Market Share Analysis
8. Spain Psoriasis Market Insights
8.1. Marketed Drugs for Psoriasis in Spain
8.2. Spain Psoriasis Market Size & Forecast
8.3. Spain Psoriasis Product Sales Forecast
8.4. Spain Psoriasis Market Share Analysis
9. UK Psoriasis Market Insights
9.1. Marketed Drugs for Psoriasis in UK
9.2. UK Psoriasis Market Size & Forecast
9.3. UK Psoriasis Product Sales Forecast
9.4. UK Psoriasis Market Share Analysis
10. Europe Psoriasis Market Insights
10.1. Europe Psoriasis Market Size & Forecast
10.2. Europe Psoriasis Product Sales Forecast
10.3. Europe Psoriasis Market Share Analysis
11. Japan Psoriasis Market Insights
11.1. Marketed Drugs for Psoriasis in Japan
11.2. Japan Psoriasis Market Size & Forecast
11.3. Japan Psoriasis Product Sales Forecast
11.4. Japan Psoriasis Market Share Analysis
12. Global Psoriasis Market Insights
12.1. Global Psoriasis Market Size & Forecast
12.2. Global Psoriasis Product Sales Forecast
12.3. Global Psoriasis Market Share Analysis
13. Research Methodology
For more information about this report visit https://www.researchandmarkets.com/r/gig2q9
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Psoriasis Be Gone: The Diet, Activities & Ointments You Need To Get Glowing Skin – KIIS1065
Posted: at 1:58 am
And while relying on a topical treatment is a fab way of keeping skin clear, the experts at Grahams Natural Alternatives tell us many skin conditions stem from inside our bodies.
Heres their top tips for dealing with skin conditions like psoriasis, a common, chronic inflammatory disease which affects about 3% of the worldwide population!
Research shows some antioxidant rich foods like garlic, onions, green leafy veggies, avocado and broccoli can actually prevent skin conditions caused by inflammation in the body.Furthermore if you rock a diet high in anti-inflammatory foods such as berries, fish like salmon rich in omega 3 and nuts or seeds, can be great for psoriasis sufferers who experience inflamed skin as a result of their condition.
Hate to tell you, but its three of the best. Research shows gluten, sugar and alcohol can trigger a flare or worsen your existing symptoms. The team at Grahams Natural Alternatives say you might not have to give up completely, just start by limiting your intake to see if it can help reduce the symptoms, or at least avoid these foods while youre psoriasis is bad.
Psoriasis is an autoimmune disease, it is important to take an internal oil supplement full of fatty acids and omegas. The Grahams Natural Alternativesteam recommend their mega oilto heal your body from the inside out.
Regular exercise. Doing as little as 30 minutes of exercise a day can improve your mental and physical health just remember to wash the sweat off any break out zones to avoid a flare out up when you can home.
Topical treatments will work best if you combine all of the tips above, but our fave is Grahams Natural Psoriasis Cream, which has been scientifically formulated to treat psoriasis naturally.
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Psoriasis Be Gone: The Diet, Activities & Ointments You Need To Get Glowing Skin - KIIS1065
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Dermavant Announces Publication in JAAD of Secondary Efficacy and Patient-Reported Outcomes in Phase 2b Clinical Trial of Tapinarof Cream for the…
Posted: at 1:58 am
LONG BEACH, Calif. & BASEL, Switzerland--(BUSINESS WIRE)-- Dermavant Sciences, a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology, today announced the publication of secondary efficacy and patient-reported outcomes from its Phase 2b randomized clinical trial of tapinarof cream for the treatment of atopic dermatitis in The Journal of the American Academy of Dermatology (JAAD)1, the peer-reviewed scientific publication of the American Academy of Dermatology (AAD). Tapinarof cream is a potential first-in-class, once-daily topical therapeutic aryl hydrocarbon receptor modulating agent (TAMA) for the treatment of plaque psoriasis and atopic dermatitis.
The latest analyses of the Phase 2b study published in JAAD include 75%, and 90% improvement in the Eczema Area and Severity Index from baseline (EASI75, EASI90), in addition to mean percentage change in EASI scores, the mean change in percentage of body surface area (BSA) affected, and mean change in total severity score.
Patient-reported outcomes include the proportion of patients who achieved 3-point improvement in pruritus (itch) numeric rating scale (NRS) score from baseline, subject impression of severity of atopic dermatitis symptoms, and subject impression of overall change in severity of itch symptoms from baseline to Week 12. The expanded Patient-Oriented Eczema Measure (POEM) was used to assess itch, sleep disturbance, and skin signs and symptoms, and the Daily Signs and Symptoms Severity Diary to score 11 disease-related symptoms.
Highlights from the Secondary Efficacy and Patient-Reported Outcomes
Secondary Efficacy Outcomes:
Post-hoc Analysis:
Additional Patient-Reported Outcomes:
As previously reported in JAAD2, most adverse events were mild or moderate. The most commonly reported adverse events were nasopharyngitis, folliculitis, and atopic dermatitis.
We are excited that JAAD has shared this additional evidence of tapinarofs clinical response with these secondary efficacy and patient-reported outcomes from the Phase 2b study for atopic dermatitis, said David Rubenstein, M.D., Ph.D., Chief Scientific Officer of Dermavant. Because atopic dermatitis can interfere with daily life, these outcomes are especially important to patients, their caregivers, and the physicians who treat them. Dermatologists have shared with us their interest in potential topical treatment options that can address and relieve some of the very problematic symptoms of this debilitating skin disease, and todays data speaks to the potential of tapinarof to meet this demand, subject to FDA approval.
About the Tapinarof Phase 2b Atopic Dermatitis Study
In the Phase 2b double-blind, vehicle-controlled, multicenter study, 247 adolescent and adult patients aged 12-65 years diagnosed with mild to moderate atopic dermatitis involving between 5% and 35% body surface area were enrolled. Patients were randomized 1:1:1:1:1:1 to tapinarof cream 0.5%, tapinarof cream 1.0%, or vehicle, each applied to affected areas either once daily (QD) or twice daily (BID) for 12 weeks with a 4-week follow-up. In total, 165 patients were randomized to an active arm and 82 to vehicle.
The primary endpoint of the study (previously reported and published in JAAD) was an Investigator Global Assessment (IGA) score of clear (0) or almost clear (1) with a minimum 2-grade improvement from baseline at Week 12.2
About Atopic Dermatitis
Atopic dermatitis (AD), commonly referred to as eczema, is a chronic inflammatory skin disease that results in itchy, red, swollen, and cracked skin, often affecting the folds of the arms, back of the knees, hands, face, and neck. AD is one of the most common inflammatory skin diseases, affecting over 28 million people in the U.S. alone and up to 10% of adults worldwide. AD occurs most frequently in children, affecting up to 30% worldwide.
People with AD are more likely to have other allergic conditions, like asthma, allergic rhinitis, and food allergies. Itching is an especially bothersome symptom in AD, and tends to worsen at night, disturbing sleep and causing fatigue, which in children can lead to inattention at school. People with AD may also experience social and emotional distress due to the visibility and discomfort of the disease.
About Dermavant
Dermavant Sciences, a subsidiary of Roivant Sciences, is a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology. Dermavants focus is to develop therapies that have the potential to address high unmet medical needs while driving greater efficiency in research and clinical development. The companys robust medical dermatology pipeline includes both late-stage and early-development product candidates that target specific unmet needs in two of the largest growing immuno-dermatology markets, psoriasis and atopic dermatitis, as well as other large markets, including vitiligo, primary focal hyperhidrosis, and acne. Dermavant is developing its lead product candidate, tapinarof (DMVT-505), as a novel therapeutic aryl hydrocarbon receptor modulating agent (TAMA) topical cream for the treatment of plaque psoriasis and atopic dermatitis, which affect approximately 8 million and 28 million people in the United States, respectively. For more information, please visit http://www.dermavant.com, and follow us on Twitter (@dermavant) and LinkedIn (Dermavant Sciences).
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View source version on businesswire.com: https://www.businesswire.com/news/home/20200616005040/en/
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Dermavant Announces Publication in JAAD of Secondary Efficacy and Patient-Reported Outcomes in Phase 2b Clinical Trial of Tapinarof Cream for the...
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Global Psoriasis Treatment Market Analysis 2020 with COVID-19 | Growth, Trend, Competitive Strategies and Forecast 2025 – Flagler Times
Posted: at 1:58 am
Researchstore.biz added a research publication document on Global Psoriasis Treatment Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 breaking major business segments and highlighting wider level geographies to get deeper analysis on market data. The report gives significant information associated with the global Psoriasis Treatment industry analysis size, share, application, and statistics that are summed in the report to present a market prediction. It gives a thought with respect to the advancement of the market movement of significant players of the market. The study covers top players analyses based on competitive landscape, demand and supply side, revenue and global market share.
NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.
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Market Introduction:
The research report is formulated with the most excellent and superior tools of collecting, recording, estimating and analyzing market data of the global Psoriasis Treatment industry. Market segmentation studies conducted with respect to product type, applications, and geography are valuable in taking any verdict about the products. Market analysis has been prepared by taking into account aspects of marketing research and analysis, market size estimations, segmentation, competitive landscaping, opportunity analysis, economic forecasting, growth rate, future trends, market drivers, opportunities, challenges, risks, entry barriers, sales channels. Market dynamics covered by the report include drivers, opportunities, challenges, risks, entry barriers, sales channels. Each division of the market is researched and isolated based on type, applications, and the end-customers.
Major market players covered in this report: Novartis International AG, Merck and Co. Inc., Johnson& Johnson, Pfizer Inc., Eli Lilly, AbbVie and Amgen
On the basis of product, this report displays the production, revenue, price, market share, and growth rate of each type, primarily split into: TNF Inhibitors, Phosphodiesterase Inhibitors, Interleukin Blockers, Others,
On the basis of the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate for each application, including: Oral, Injectable,
Key geographies evaluated in this report are: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.), Middle East& Africa (Saudi Arabia, Egypt, Nigeria and South Africa)
The report explores product scope, product market by end-users or application, product market by region, the market size for the specific product type, sales and revenue by region forecast the market size for various segments. The global Psoriasis Treatment market maps the qualitative impact of the particular market based on its segments and geographies. The document covers the competitive landscape of this market and the multiple regions where the business has successfully established its position.
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Global Psoriasis Treatment Market Analysis 2020 with COVID-19 | Growth, Trend, Competitive Strategies and Forecast 2025 - Flagler Times
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SpaceX to build floating spaceports for rockets bound for the Moon and Mars, and for hypersonic Earth travel – TechCrunch
Posted: at 1:49 am
SpaceX is hiring experts in Offshore Operations in Brownsville, job ads revealed on Tuesday and the purpose is to help the company develop and build floating spaceports that will provide launch sites for the companys Super Heavy-class launch vehicles. SpaceX will use these larger rockets to get its forthcoming large payload rockets to the Moon, to Mars and also for point-to-point travel right here on Earth, according to SpaceX CEO Elon Musk.
Musk said on Twitter that this was the purpose behind the new job posting, which was originally spotted by Dan Paasch. SpaceX has previously shown concepts of its forthcoming Super Heavy rocket booster, paired with its Starship spacecraft, launching for hypersonic Earth travel which would reduce the trip time for long-haul flights to merely a couple of hours. Those concepts have thus far consisted only of renders, however, and we didnt know what the plan was in terms of how and from where those spacecraft would launch until today.
Starship and Super Heavy are primarily being developed to help SpaceX and Musk realize their goal of delivering human to Mars, in order to colonize that and other interstellar destinations including the Moon to make humans an interstellar species. But while those goals may seem out of reach to most people, the companys aims of using the same fully reusable spacecraft to greatly decrease the cost of point-to-point supersonic travel here on Earth are likely to be much more relevant.
Point-to-point space-based transportation is not a new concept, and others beyond SpaceX are working on developing ways to make this happen. The idea is that by traveling at the edge of, or beyond Earths atmosphere, you can greatly reduce the fuel cost and duration of flight traveling the distance between New York and Paris, for instance, in under an hour. In fact, SpaceX claimed during a presentation in 2017 that point-to-point transportation with its Starship could reach any city on Earth from any other city in less than an hour.
SpaceX has been developing Starship in Texas, near Brownsville where this new job posting is seeking Offshore Operations Engineers. The company has been expanding its testing and development site in the area, and has also sought to increase the resources dedicated to its operations in the state.
Musk didnt share much more about the plans, but did say in response to another tweet that claimed this amounted to Referb[ushing] oil platforms with a hyperloop to transport from land was pretty much part of the plan, so that could be involved in shuttling passengers back and forth to and from their departure and destination spaceports.
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Scientists developed a polymer that can deliver oxygen for germination on Mars – ZME Science
Posted: at 1:49 am
Although its little more than a barren wasteland nowadays, our planetary neighbor Mars is similar in many ways to Earth. Its length of day, dry surface area, and general relief are similar to those on Earth, which makes the Red Planet a prime target for an eventual colonization attempt.
But if we want to set up a permanent settlement on this telluric planet, there are many challenges we need to overcome one of them, the sustainable cultivation of edible crops, has just made a revolutionary leap forward.
In a recently published paper, researchers John G. MacDonald, Karien Rodriguez and Stephen Quirk developed an oxygen delivery polymer that enabled the first successful germination in a Mars-like environment.
On Mars, there already are already some resources that we can use to grow harvestable plants. For instance, the layer of loose, soil-like material called regolith contains chemical elements such as phosphorous, iron, and potassium all of which are needed for most plants to grow. However, until now, it has not been possible to successfully germinate plants conditions such as those on Mars.
The problem or at least, part of the problem is oxygen.
While plants are able to supply their own oxygen after some time, it is needed in molecular form for most plants to develop from seed to seedling. Unfortunately, the Martian atmosphere consisting of 95% carbon dioxide, contains mere traces of oxygen.
While there are types of plants capable of anoxic germination (most noticeably rice) this adaptation comes with some major drawbacks like a reduction of cellular respiration which is why they have to rely on the little efficient fermentation as an energy source.
Molecular oxygen is also needed for the redox reactions that produce generating reactive oxygen species (ROS) with essential signaling functions.
There are two ways of obtaining oxygen in a Mars-like environment: extract it from regolith metal oxides, and electrolysis. Both have some major downsides, namely time consumption and proximity to water respectively.
In a recent paper, scientists propose a different approach: they developed a polymer system. When combined with sodium hydroxide and hydrogen peroxide, the polymer becomes an oxygen infused foamed hydrogel which can deliver controlled amounts of gaseous oxygen. The foamed matrix can be mixed into the regolith or coated around the seed and can be used to grow plants.
In other words, for the first time in history, scientists succeeded in germinating plants in a martian environment. Cress, a typical test object for plant research, grew almost identically in the uninviting environment when the polymer system was used in comparison to the control group.
The findings of the scientists from Georgia, US, could mean a big step forward towards the distant possibility of a human colony on Mars.
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Scientists developed a polymer that can deliver oxygen for germination on Mars - ZME Science
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Could Mars Science City in Dubai be the future for life on other planets? – DubaiLAD
Posted: at 1:49 am
Architects have started to come up with possible designs for Mars Science City in Dubai as the UAE plans for life on Mars within 100 years.
Back in 2017, the UAE announced that it wanted to colonize Mars within the next 100 years. And so they created Mars Science City, a 176,000 square meters of desert where a simulation of life on Mars could be created.
And that $135 million is starting to come through as prototype designs have been released by the Dubai Media Office of what Mars Science City could look like.
.@CNN: The planned Mars Science City is only one part of the ambitious space program run by #Dubai's @MBRSpaceCentre. Last year it sent its first astronaut into space; this summer it will launch a probe to Mars, and in November it will undertake its first-ever analog mission. pic.twitter.com/PkeS4wMx9N
The UAEs space mission has gone into lightspeed since 2017.
The UAE are launching the Hope probe to Mars later this year. The Hope will study the atmosphere on Mars for two years from a high altitude position. While there, it will take in vital weather readings across a full Martian weather cycle.
While in 2019, they sent Hazza Al Mansouri to space, becoming the first Emirati in space. In total, he spent eight days on board the ISS last year.
While there, he notched up a number of inter-galactic firsts including the first to give a tour of the ISS in Arabic. And he was the first to eat Arabic food in space. Which, we can all agree, is legendary behaviour.
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Could Mars Science City in Dubai be the future for life on other planets? - DubaiLAD
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Yes to Space Exploration. No to Space Capitalism. – The Wire
Posted: at 1:49 am
Elon Musk. Photo: Reuters.
On May 30, SpaceX finally launched astronauts into space more than two years behind schedule. President Donald Trump was on hand for the launch. After pushing for the militarisation of space with the formation of the US Space Force, Trump fused his own vision with that of SpaceX founder Elon Musk, declaring, Well soon be landing on Mars and well soon have the greatest weapons ever imagined in history.
Early in Trumps presidency, Musk faced criticism for being part of the administrations advisory council and refusing to step down even as Trump signed his signature Muslim ban. It was believed Musk was hoping to benefit from greater public subsidies, on top of the billions NASA gave to SpaceX, and hes set to do so as part of Trumps plan to get astronauts back on the moon by 2024. More recently, the two have found themselves of the same mind on the pandemic as they shared misleading health information and Musk echoed Trumps calls to open the economy and give people their freedom back.
The May 30 launch symbolised both Trumps desire to project an image of revived American greatness and Musks need not only to bolster the myth that makes his wealth possible, but to set the foundations for a privatised space industry.
The space billionaires Musk and Amazon CEO Jeff Bezos foremost among them have little stake in the wellbeing of the majority of the population. Their space visions are designed for wealthy people like themselves, with little mention of where the working class would fit in. Theyve built their wealth on exploitation, and their visions of the future are little more than an extension of their present actions.
A history of violence
The business practices of Musk and Bezos are increasingly well known and have been on clear display during the pandemic. Musk tried to claim Teslas Fremont, California factory was essential until authorities forced him to close it; then he reopened it in defiance of health orders. As Tesla CEO, Musk has a long history of opposing the unionisation of workers, presiding over a high rate of worker injuries (which the company tried to cover up), and even having a former worker hacked and harassed after he became a whistleblower.
Meanwhile, Bezos has a similar history of abusing Amazon workers. Amazons warehouses are known for having higher injury rates than the industry average, the company has fought unionisation, and the stories of the terrible conditions experienced by workers are legendary. During the pandemic, that has continued, with the company failing to enforce social distancing or provide adequate protective equipment until workers began walking out, refusing to be open about infection information, and firing workers who dared criticise the company, all while Bezoss wealth has increased by more than $30 billion.
But it goes beyond that, because the worldviews of these billionaires began to be formed long before they started the empires they currently lord over.
Musk did not have a regular childhood, but rather a wealthy upbringing in apartheid South Africa. His father was an engineer and owned part of an emerald mine in Zambia, telling Business Insider, We were very wealthy. We had so much money at times we couldnt even close our safe. In Elon Musk: Tesla, SpaceX, and the Quest for a Fantastic Future, Ashlee Vance describes how Musk got money from his father when he was starting one of his original ventures. He also had a particular admiration for his grandfather, who moved to apartheid South Africa from Canada after rallying against government interference in the lives of individuals.
Bezos has a not-dissimilar story. His father was a well-off oil engineer in Cuba while Fulgencio Batista was in power. In Bit Tyrants, Rob Larson explains that Bezoss father left the island after the Cuban Revolution and passed his libertarian views down to his son. Bezoss parents invested nearly $250,000 in Amazon in 1995 as it was getting started.
These space barons made their billions through the exploitation of their workers and came from well-off backgrounds made possible from resource extraction. When digging into their visions for a future in space, its clear that they seek to extend these conditions into the cosmos, not challenge them in favour of space exploration for the benefit of all.
The future they want
Musk and Bezos are the leading drivers of the modern push to privatise and colonise space through their respective companies, SpaceX and Blue Origin. Their visions differ slightly, with Musk preferring to colonise Mars, while Bezos has more interest in building space colonies in orbit.
In 2016, Musk claimed he would begin sending rockets to Mars in 2018. That never happened, but it hasnt ended his obsession. Musk is determined to make humans a multi-planetary species, framing our choice as either space colonisation or the risk of extinction. Bezos says that Earth is the best planet in our solar system, but if we dont colonize space we doom ourselves to stasis and rationing.
These framings serve the interests of these billionaires, and make it seem like colonising space is an obvious and necessary choice when it isnt. It ignores their personal culpability and the role of the capitalist system they seek to reproduce in causing the problems they say we need to flee in the first place.
Billionaires have a much greater carbon footprint than ordinary people, with Musk flying his private jet all around the world as he claims to be an environmental champion. Amazon, meanwhile, is courting oil and gas companies with cloud services to make their business more efficient, and Tesla is selling a false vision of sustainability that purposely serves people like Musk, all while capitalism continues to drive the climate system toward the cliff edge. Colonising space will not save us from billionaire-fuelled climate dystopia.
But these billionaires do not hide who would be served by their futures. Musk has given many figures for the cost of a ticket to Mars, but theyre never cheap. He told Vance the tickets would cost $500,000 to $1 million, a price at which he thinks its highly likely that there will be a self-sustaining Martian colony. However, the workers for such a colony clearly wont be able to buy their own way. Rather, Musk tweeted a plan for Martian indentured servitude where workers would take on loans to pay for their tickets and pay them off later because There will be a lot of jobs on Mars!
Bezos is even more open about how the workforce will have to expand to serve his vision, but has little to say about what theyll be doing. His plan to maintain economic growth and dynamism requires the human population to grow to a trillion people. He claims this would create a thousand Mozarts and a thousand Einsteins who would live in space colonies that are supposed to house a million people each, with the surface of Earth being mainly for tourism. Meanwhile, industrial and mining work would move into orbit so as not to pollute the planet, and while he doesnt explicitly acknowledge it, its likely thats where youll find many of those trillion workers toiling for their space overlord and his descendants.
Space shouldnt serve capitalists
In 1978, Murray Bookchin skewered a certain brand of futurism that sought to extend the present into the future and desired multinational corporations to become multi-cosmic corporations. Much of this future thinking obsesses about possible changes to technology, but seeks to preserve the existing social and economic relations the present as it exists today, projected, one hundred years from now, as Bookchin put it. Thats at the core of the space billionaires vision for the future.
Space has been used by past US presidents to bolster American power and influence, but it was largely accepted that capitalism ended at the edge of the atmosphere. Thats no longer the case, and just as past capitalist expansions have come at the expense of poor and working people to enrich a small elite, so too will this one. Bezos and Trump may have a public feud, but that doesnt mean that their mutual interest isnt served by a renewed US push into space that funnels massive public funds into private pockets and seeks to open celestial bodies to capitalist resource extraction.
This is not to say that we need to halt space exploration. The collective interest of humanity is served by learning more about the solar system and the universe beyond, but the goal of such missions must be driven by gaining scientific knowledge and enhancing global cooperation, not nationalism and profit-making.
Yet thats exactly what the space billionaires and American authoritarians have found common cause in, with Trump declaring that a new age of American ambition has now begun at a NASA press briefing just hours before cities across the country were placed under curfew last week. Before space can be explored in a way that benefits all of humankind, existing social relations must be transformed, not extended into the stars as part of a new colonial project.
This article was first published on Jacobin. Read the originalhere.
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Yes to Space Exploration. No to Space Capitalism. - The Wire
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