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A Genome-Wide Association Study in Early COPD: Identification of One M | COPD – Dove Medical Press
Posted: November 22, 2020 at 9:46 pm
Ye-Jin Lee,1 SeungHo Choi,2 Sung-Youn Kwon,2 Yunhwan Lee,2 Jung Kyu Lee,3 Eun Young Heo,3 Hee Soon Chung,3,4 Deog Kyeom Kim3,4
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea; 2Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 135-984 Korea; 3Division of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea; 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Correspondence: Deog Kyeom KimDivision of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Boramae-Gil 41, Dongjak-gu, Seoul 156-707, Republic of KoreaTel +82-2-870-3207Fax +82-2-831-0714Email kimdkmd@gmail.com
Background: Identifying the genetic basis of airflow limitation is one of the most interesting issues for understanding chronic obstructive pulmonary disease (COPD) pathophysiology. Several studies have shown that some genetic variants associated with COPD have been identified in genome-wide association study (GWAS), especially in patients with moderate to severe COPD; genetic susceptibility for airflow limitation in the early COPD phase has not been widely studied.Objective: We investigated the genetic variants in early COPD.Methods: The present study analyzed Gene-environment interaction and phenotype (GENIE) cohort that included participants who received health screening examination. The association between single nucleotide polymorphism (SNP) and susceptibility to early COPD (FEV1 predicted 50% and FEV1/FVC < 0.7) was tested.Results: A total of 130 patients with early COPD and 3478 controls (1700 ever smokers and 1778 never smokers) were recruited. When compared with the total controls, certain SNPs (rs2818103, rs875033, rs9354627, rs34552148) on chromosome 6 were included at the top of our list (p= 5.6 10 7 9.6 10 6) although they did not reach genome-wide significance. When compared with the never smoker controls, two SNPs (rs2857210, rs2621419) of the HLA-DQB2 gene class were persistently associated with susceptibility to early COPD.Conclusion: Certain SNPs located on chromosome 6 or the HLA-DQB2 gene were the top-scoring SNPs for the association with susceptibility to early COPD in the Korean GENIE cohort.
Keywords: early chronic obstructive pulmonary disease, genome-wide association study, single nucleotide polymorphism, SNP, HLA-DQ gene
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
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A Genome-Wide Association Study in Early COPD: Identification of One M | COPD - Dove Medical Press
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The great reset: new danger on the horizon – Amandala
Posted: November 10, 2020 at 1:43 am
Belize City, Nov. 2, 2020 Most people in Belize are either taken up these days with finding a job/income, with fears of COVID-19, or with anticipation of the General Elections of Nov. 11, 2020. But lurking in the shadows is a much more dangerous foe.
In the past it was called The New World Order, but that has been so discredited, that the wizard behind the curtain had to change the name to The Great Reset. What is this Great Reset?
The Great Reset is a new social contract that ties you to it through an electronic ID linked to your bank account and health records, and a social credit ID that will dictate every facet of your life. While the COVID-19 pandemic is being used as a justification for the Great Reset movement, the agenda has nothing to do with health and everything to do with a long-term plan to monitor and control the world through digital surveillance and artificial intelligence.
The Great Reset and the Fourth Industrial Revolution are rebranded terms for the old New World Order, melded with the trans-humanist movement. Technocracy (which is the new name for Fascism) is an economic system of resource allocation that revolves around computer technology in particular artificial intelligence, digital surveillance, and Big Data (5G) collection and the digitization of industry and government, which in turn allows for the automation of social engineering and social rule, thereby doing away with the need for democratically elected leadership.
While the real plan is to usher in a tech-driven dystopia free of democratic controls, the elites speak of this plan as a way to bring us back into harmony with nature the Green New Deal. Importantly, the pandemic is being used to destroy local economies around the world, which will then allow the World Economic Forum to come in through the IMF and rescue debt-ridden countries through facilitated financial bailouts.
However, the price for this salvation is your personal freedom and liberty. And, again, one of the aspects of the Fascist plan is to eliminate national borders and nationalism in general.
Who are the main actors behind the Great Reset?
Bill Gates and the World Economic Forum, along with the United Nations (which keeps a relatively low profile), appear to be at the heart of the big boys agenda. Gates is also the largest money-bag for the World Health Organization the medical branch of the U.N. Other key partners that play important roles in the implementation of the elites/globalists agenda include foundations such as the Rockefeller Foundation, the Rockefeller Brothers Fund, the Ford Foundation, Bloomberg Philanthropies, the UN Foundation, and George Soros Open Society Foundation; companies such as: Avanti Communications, a British provider of satellite technology with global connectivity, and 2030 Vision, a partnership of technology giants that is aimed at providing the infrastructure and technology solutions needed to realize the U.N.s 2030 Sustainable Development Goals. 2030 Vision is also partnered with Frontier 2030, which is a partnership of organizations under the helm of the World Economic Forum.
These organizations include the major Wall Street bankers/financiers; Google, the No. 1 Big Data collector in the world and a leader in AI services; MasterCard, which is leading the globalist charge to develop digital IDs and banking services, and Salesforce, a global leader in cloud computing, the internet of things and artificial intelligence.
Incidentally, Salesforce is led by Marc Benioff, who is also on the World Economic Forums board of directors, and Professor Klaus Schwab, chairman of the World Economic Forum.
Most Belizeans know little or nothing about the trans-humanist movement, or Human 2.0, which is geared at transcending biology through computer technology. Or, as Dr. Carrie Madej of USA explains in a blog, their goal is to meld human biology with computer technology and artificial intelligence. Two visible proponents of trans-humanism are Ray Kurzweil (director of engineering at Google since 2012) and Elon Musk (founder of SpaceX, Tesla and Neuralink). According to Dr. Madej, today we may be standing at the literal crossroads of trans-humanism, thanks to the fast approaching release of one or more mRNA COVID-19 vaccines.
Many of the COVID 19 vaccines https://articles.mercola.com/sites/articles/archive/2020/05/22/coronavirus-vaccine-timetable.aspx are not conventional vaccines. Their design is aimed at manipulating your very biology, and therefore have the potential to alter the biology of the entire human race. Conventional vaccines train your body to recognize and respond to the proteins of a particular virus by injecting a small amount of the actual viral protein into your body, thereby triggering an immune response from your body and the development of antibodies.This is not what happens with an mRNA vaccine. The theory behind these vaccines is that when you inject the mRNA into your cells, it will stimulate your cells to manufacture their own viral protein. The mRNA COVID-19 vaccine will be the first of its kind. No mRNA vaccine has ever been licensed before. And, to add insult to injury, theyre forgoing all animal safety testing.
Madej has reviewed the background of certain individuals participating in the race for a COVID-19 vaccine, which include Moderna co-founder Derrick Rossi, a Harvard researcher who successfully reprogrammed stem cells using modified RNA, thus changing the function of the stem cells. Moderna was founded on this concept of being able to modify human biological function through genetic engineering.
The mRNA vaccines are designed to instruct your cells to make the SARS-CoV-2 spike protein, the glycoprotein that attaches to the ACE2 receptor of the cell. The idea is that by creating the SARS-CoV-2 spike protein, your immune system will mount a response to it and begin producing antibodies to the virus.
However, as we now know, Moderna is having problems, because both the CEO and CFO have, according to the Wall Street Journal, dumped their shares and sold everything, making some $350 million + dollars.
But the biggest insult by the globalists to our intelligence is the censorship of the news about the research done by genetic analysis using the Oak Ridge National Lab supercomputer called the Summit which has revealed an interesting new hypothesis that helps explain the disease progression of COVID-19. A September 1, 2020 Medium article1 by Thomas Smith reviewed the findings of what is now referred to as the Bradykinin hypothesis.
As reported by Smith, the computer crunched data on more than 40,000 genes obtained from 17,000 genetic samples.
Summit is the second-fastest computer in the world, but the process which involved analysing 2.5 billion genetic combinations still took more than a week. When Summit was done, researchers analysed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a eureka moment.
Bradykinin is a chemical that helps regulate your blood pressure and is controlled by your renin-angiotensin system (RAS). As explained in the Academic Press book on vitamin D (which has a significant impact on the RAS):
The renin-angiotensin system (RAS) is a central regulator of renal and cardiovascular functions. Over-activation of the RAS leads to renal and cardiovascular disorders, such as hypertension and chronic kidney disease, the major risk factors for stroke, myocardial infarction, congestive heart failure, progressive atherosclerosis, and renal failure.
The Bradykinin hypothesis provides a model that helps explain some of the more unusual symptoms of COVID-19, including its bizarre effects on the cardiovascular system. It also strengthens the hypothesis that vitamin D plays a really important role in the disease.
Your ACE2 receptors are the primary gateways of the virus, as the virus spike protein binds to the ACE2 receptor. As explained2 by Smith:
COVID-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose The virus then proceeds through the body, entering cells in other places where ACE2 is also present But once Covid-19 has established itself in the body, things start to get really interesting The data Summit analysed shows that COVID-19 isnt content to simply infect cells that already express lots of ACE2 receptors. Instead, it actively hijacks the bodys own systems, tricking it into up-regulating ACE2 receptors in places where theyre usually expressed at low or medium levels, including the lungs.
In this sense, COVID-19 is like a burglar who slips in your unlocked second-floor window and starts to ransack your house. Once inside, though, they dont just take your stuff they also throw open all your doors and windows so their accomplices can rush in and help pillage more efficiently.
The end result is a Bradykinin storm, and according to the researchers, this appears to be an important factor in many of COVID-19s lethal effects, even more so than the Cytokine storms associated with the disease. As Bradykinin accumulates, the more serious COVID-19 symptoms appear. Mounting clinical data suggest COVID-19 is actually primarily a vascular disease rather than a respiratory one, and runaway Bradykinin build-up help explain this.
The good news is that since Bradykinin storms are to blame, there are a number of already existing drugs (Icatibant, Danazol, Stanozolol) that can help prevent Bradykinin storms, and there are many other safe, inexpensive strategies like nebulized peroxide, ozone, molecular hydrogen, steroids, exogenous ketones, and Quercetin with zinc, vitamin D, and high-dose vitamin C.
And there are two reports by the American CDC. One says that 70.6% of COVID-19 patients always wore a mask3. The other says only 6% of all COVID-19 deaths were due ONLY to coronavirus4. And yet another said that the common seasonal flu caused more deaths than COVID-19.
So, if COVID-19 deaths are not what is being reported by the mass media, if the SAR CoV-2 virus is not as deadly to humans, then why the lockdowns, the face masks, the social distancing, the destruction of the way we live, of our economies? Why? Why?
But not all men are blind. On Oct 25, 2020, the Archbishop of Ulpiana, former Apostolic Nuncio to the United States of America, Carlo Maria Vigano, wrote an open letter (which over 100 million Americans have read) to President Donald Trump. The letter is long and is all over the internet. This is some of it:
at this hour in which the fate of the whole world is being threatened by a global conspiracy against God and humanityin the midst of the silence of both civil and religious authoritiesthis historical moment sees the forces of Evil aligned in a battle against the children of Lightwe see heads of nations and religious leaders pandering to this suicide of Western culture and its Christian soul, while the fundamental rights of citizens and believers are denied in the name of a health emergency that is revealing itself more and more fully as instrumental to the establishment of an inhuman faceless tyranny.
A global plan called the Great Reset is underway. Its architect is a global lite that wants to subdue all of humanity, imposing coercive measures with which to drastically limit individual freedoms and those of entire populations Behind the world leaders who are the accomplices and executors of this infernal project, there are unscrupulous characters who finance the World Economic Forum and Event 201, promoting their agenda.
The purpose of the Great Reset is the imposition of a health dictatorship aiming at the imposition of liberticidal measures, hidden behind tempting promises of ensuring a universal income and cancelling individual debt. The price of these concessions from the International Monetary Fund will be the renunciation of private property and adherence to a program of vaccination against Covid-19 and Covid-21 promoted by Bill Gates with the collaboration of the main pharmaceutical groups. Beyond the enormous economic interests that motivate the promoters of the Great Reset, the imposition of the vaccination will be accompanied by the requirement of a health passport and a digital ID, with the consequent contact tracing of the population of the entire world. Those who do not accept these measures will be confined in detention camps or placed under house arrest, and all their assets will be confiscated.
Mr President, I imagine that you are already aware that in some countries the Great Reset will be activated between the end of this year and the first trimester of 2021. For this purpose, further lockdowns are planned, which will be officially justified by a supposed second and third wave of the pandemic. But this world, Mr. President, includes people, affections, institutions, faith, culture, traditions, and ideals: people and values that do not act like automatons, who do not obey like machines, because they are endowed with a soul and a heart, because they are tied together by a spiritual bond that draws its strength from above, from that God that our adversaries want to challenge, just as Lucifer did at the beginning of time with his non serviam.
Until a few months ago, it was easy to smear as conspiracy theorists those who denounced these terrible plans, which we now see being carried out down to the smallest detail. No one, up until last February, would ever have thought that, in all of our cities, citizens would be arrested simply for wanting to walk down the street, to breathe, to want to keep their business open, to want to go to church on Sunday. Yet, now it is happening all over the world.
Mr. President, you have clearly stated that you want to defend the nation One Nation under God, fundamental liberties, and non-negotiable values that are denied and fought against today. It is you, dear President, who are the one who opposes the deep state, the final assault of the children of darkness.
For this reason, it is necessary that all people of goodwill be persuaded of the epochal importance of the imminent election Your adversary is also our adversary: it is the Enemy of the human race, He who is a murderer from the beginning (Jn 8:44).
And yet, in the midst of this bleak picture, this apparently unstoppable advance of the Invisible Enemy, an element of hope emerges. The adversary does not know how to love, and it does not understand that it is not enough to assure a universal income or to cancel mortgages in order to subjugate the masses and convince them to be branded like cattle. This people, which for too long has endured the abuses of a hateful and tyrannical power, is rediscovering that it has a soul; it is understanding that it is not willing to exchange its freedom for the homogenization and cancellation of its identity; it is beginning to understand the value of familial and social ties, of the bonds of faith and culture that unite honest people.
This Great Reset is destined to fail because those who planned it do not understand that there are still people ready to take to the streets to defend their rights, to protect their loved ones, to give a future to their children and grandchildren. The levelling inhumanity of the globalist project will shatter miserably in the face of the firm and courageous. To be an instrument of Divine Providence is a great responsibility, for which you will certainly receive all the graces of state that you need, since they are being fervently implored for you by the many people who support you with their prayers.
Meanwhile, here in Belize, we kill our so-called COVID-19 patients. Ventilators will kill you. Doctors of Belize, read the report of the US Oak Ridge National Lab on COVID-19. NO one needs to die anymore from COVID-19. US President Trump, who is 74 years old, was cured after 3 days of COVID-19.
And by the time you read this article, the world will know who won the elections in the United States.
Curfew on Nov. 11, election night in Belize, is part of the Globalist agenda. Let the people celebrate their victory. Open the churches, the schools, the bars; open the society. Send the globalist/elites back to Hell with Lucifer.
(Footnotes)1https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63
2ibid3https://www.cdc.gov/mmwr/volumes/69/wr/mm6936a5.htmRead the table at the end.4https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.html
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The great reset: new danger on the horizon - Amandala
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Nov. 4 Letters to the Editor: Our Readers’ Opinions – Lewiston Morning Tribune
Posted: at 1:43 am
COVID-19 cases reported do not reveal the true story. Most of these people have the common cold with symptoms of COVID-19.
Coronaviruses are a family of viruses that can cause illness, such as the severe acute respiratory syndrome (SARS), a leading cause of death, Middle East syndrome (MERS), also the common cold.
The new virus, which originated in China, is being called SARS-CoV-2.
These numbers are being used by hospitals, Big Pharma, corporations, doctors and greedy politicians with big pockets for money that will come from the taxpayers of America.
When it comes to doctors, it depends on which doctor you talk to.
I just went to my heart doctor. He told me all they do to is ask the COVID questions for the hospital to get paid.
He also told me all disease centers are lying about numbers. Bigger numbers mean bigger pay.
So I guess it depends on which mathematician or doctor you want to believe. You get different numbers from all of them.
Amazingly, social media reports show influenza numbers are down 93 percent this year.
Its time for term limits to keep Congress honest.
I truly thought my subscription would end this month but you have continued to send them to me.
It is my sister who reads your paper in Prosser, Wash.
We confer daily on subjects in your paper. You cover the Pacific Northwest like no other. My own paper does local news very poorly, considering we are the state capital. The national news comes from USA Today, which is so slanted and incomplete.
All the fuss over Mike Luckovichs cartoon both my sister and I were digging around in our recycling garbage barrels to recover that cartoon to try and figure out what all the trouble it caused in peoples minds (some peoples.) Good grief.
We both cut out cartoons and articles from your paper and our own. This particular cartoon wasnt significant to us (Were both Democrats). We didnt save it. And we couldnt find it.
Mine has been carried away by the D and O Garbage Service. Oh well.
I hope our present storms end with a rainbow. This election will determine a lot. ...
Save America, stop socialism sounds great when you equate socialism with a nihilist totalitarianism that will disarm you and leave you defenseless, while your children are forcibly indoctrinated by pre-sexualizing trans-humanist advocates, while the nuclear family is dismantled, and thy religion becometh outlawed.
Very, but say socialism is defeated, Social Security is privatized and the stock market inevitably crashes. The entire working population is left in the lurch by international thieves and their congressional hench-persons, while glyphosate continues to cover our food. Tap water becomes undrinkable across the country, causing drinking water to become a precious commodity. And that gets bottled in petrochemical plastic, which disrupts the endocrine system. Friends and family lose their homes because they cant pay medical bills. And homeless armies roam the streets with chemically induced super powers.
Capitalism versus socialism? Why not both?
Then when I am protesting the last tree falling, I can get jailed for using the wrong gender pronoun.
As conceptual models, both isms have their value, obviously, but within a larger, richer narrative in which they are contextually applicable, not subtext for inhumane leverage nor pretext for the justification of that leverage.
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Researchers identify another health benefit of Vitamin D supplements – PhillyVoice.com
Posted: November 7, 2020 at 9:03 pm
Children with severe eczema may find better relief from their symptoms by supplementing their standard treatment with vitamin D, a new study finds.
While previous research has shown that adding vitamin D supplementation to standard care lessens symptoms in mild to moderate eczema, this is the first to confirm similar results in more severe cases.
Children with eczema suffer from itchy, dry skin. Themost common treatmentsare steroid creams and ointments, oral corticosteroids and sometimes antibiotics to help reduce inflammation.
The study's findings, published in the journalPharmacology Research & Perspectives, show that adding a daily, oral vitamin D supplement to standard care for 12 weeks led to a significantly reduced eczema areas compared to participants who were given a placebo along with standard care.
Of course, the importance of vitamin D to people's health is no secret. Proper levels are important for strong bones as well as cell growth and brain health.
A vitamin D deficiency is thought to increase risk for osteoporosis, heart disease, certain cancers, multiple sclerosis and dementia. It has also been linked to an increased risk for the development of attention deficit hyperactivity disorder in children.
The body creates vitamin D from direct sunlight on the skin. People also get it from certain foods, like oily fish think salmon, mackerel and sardines as well as red meat, eggs and fortified breakfast cereals.
For people who can't get enough vitamin D naturally, or those who have a medical condition that interferes with its absorption into the body, supplementation can boost their natural levels.
It isn't always clear who would benefit the most from a vitamin D supplement. Some studies show that for certain health issues, it doesn't offer any significant benefits.
One recent study found that vitamin D supplements don't offer any protective effect against depression.The findings of another study in The American Journal of Clinical Nutritionsuggest it doesn't significantly reduce the risk of cancer or cancer mortality either.
While there is strong evidence that vitamin D supplementation can improve bone health, its impact on other health conditions is still not completely clear, Harvard Health experts say.
Another concern is that too much vitamin D can actually be dangerous to your health. The recommended daily amount of vitamin D is 400 international units for children up to age 12 months, 600 IU for ages 1 to 70 years, and 800 IU for people over 70 years, according to the Mayo Clinic.
The bottom line is that people should talk to their health care providers about all the risks and benefits of vitamin D supplementation before taking it. And if they decide to start it, they should watch the dosage carefully.
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Researchers identify another health benefit of Vitamin D supplements - PhillyVoice.com
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Eating certain foods may cause your skin to erupt in a raging flare – what to avoid – Express
Posted: at 9:03 pm
Eczema, also called atopic dermatitis, is a condition that causes the skin to become itchy, dry and cracked. According to the NHS, some people only have small patches of dry skin, but others may experience widespread inflamed skin all over the body. "People with atopic eczema usually have periods when symptoms are less noticeable, as well as periods when symptoms become more severe - this is known as flare-ups.
Unfortunately, eczema is a life-long condition but flare-ups can be largely avoided if you steer clear of triggers.
"A GP will work with you to establish what might trigger the eczema flare-ups, although it may get better or worse for no obvious reason," explains the NHS.
Some people find the foods they eat can have an adverse impact on their eczema symptoms.
According to the National Eczema Association (NEA), for some people, certain foods like sugar, eggs or dairy cause their skin to "erupt in a raging eczema flare".
READ MORE:Eczema treatment: Experiencing a flare-up? Apply this to your skin immediately
To minimise the risks of dietary-induced flare-ups, the Eczema Foundation recommends adhering to the following dietary principles:
According to the NHS, you should not make significant changes to your diet without first speaking to a GP, however.
"It may not be healthy to cut these foods from your diet, especially in young children who need the calcium, calories and protein from these foods," warns the health body.
As it explains, if a GP suspects a food allergy, you may be referred to a dietitian (a specialist in diet and nutrition).
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They can help to work out a way to avoid the food you're allergic to while ensuring you still get all the nutrition you need.
In addition to cutting back on certain items, increasing your intake of others may alleviate eczema symptoms.
As the EF points out, certain foods have natural anti-inflammatory properties, so it makes sense for people with an inflammatory disease to incorporate them into their diet.
It recommends the following:
Moisturising your dry skin is mission critical if you have eczema and there are a number of effective ways to do this.
According to the NEA, the best way to replace and retain moisture in the skin is to moisturise immediately after taking a bath or shower.
"Although there have not been comparative studies to pinpoint the best frequency or duration of bathing, the 'soak and seal' method of treating eczema is recommended by many healthcare providers to combat dry skin and reduce flares," says the health body.
To get the full therapeutic benefit of soak and seal, follow these steps in order:
One of the most effective ways to moisturise your skin is to apply special moisturisers called emollients.
"These special moisturisers work by hydrating and soothing your skin and helping to repair any damage," explains Bupa.
According to to the health body, they can ease pain and itching and stop your skin getting infected.
"Your doctor can prescribe emollients, but you can also buy some products from pharmacies. Use your emollients all the time, even when you dont have any symptoms," it adds.
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Mark Cuban: This kind of pitch ‘always’ results in ‘the best deal’ on ‘Shark Tank’ – CNBC
Posted: at 9:03 pm
For billionaire investor Mark Cuban, the "best deals" on ABC's "Shark Tank" happen when entrepreneurs pitch a unique product that he hadn't thought of creating himself.
"There's some 12-year-old kids somewhere coming up with an idea to do things in a way that we never would have envisioned," Cuban said during a Q&A session at the George W. Bush Center on Oct. 21.
When "that 12-year-old comes up with an idea, on 'Shark Tank' or anywhere," and presents, "I think to myself, 'Why didn't I think of that?'" he said. "Those are always the best deals."
The Sharks have often invested in innovative pitches from young entrepreneurs on the show.
For example, Cuban invested $100,000 in Simple Sugars, a skincare company created by Lani Lazzari, on season four of the show. He was impressed with her product, and together, they built Simple Sugars into a multimillion-dollar company.
He called Lazzari his "favorite entrepreneur" in 2017.
"When I invested, she was 19. When she was 11, she had eczema and wanted to come up with a natural based scrub to help with her eczema," Cuban said at an Oxford Union Q&A in 2017. "Lani is my favorite entrepreneur because she's so driven and she wants to keep an edge."
Though he did not invest, Cuban was also super impressed with kid-entrepreneurs Sofi Overton, the then-13-year-old who pitched her sock company on season 11, and Ehan Kamat, the then-17-year-old who pitched a roller to eliminate foot pain on season nine, as he thought both their products were innovative.
Cuban could relate to these young entrepreneurs, because he started selling products as a kid.
"I sold garbage bags door-to-door when I was 12 years old because my dad told me the only way I could get new basketball shoes was if I had a job," he said on a2019 episode of GQ's "Actually Me."
Throughout his teens, Cubanresold baseball cards, stamps and coins. He also worked as a box boy and laid carpet, among other "random jobs," he said in 2019. In college, Cuban said he hosted disco parties andgave dance lessons to pay for his tuition.
So Cuban is sold "when I see an entrepreneur come on and present, [and] I think to myself, 'Why didn't I think of that?'"
Disclosure: CNBC owns the exclusive off-network cable rights to "Shark Tank."
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Atopic Eczema Treatment Market 2025 Insights by Size, Growth, Trends, Share, Competitive Analysis By Emerging Technology and Advancement – PRnews…
Posted: at 9:03 pm
Market Overview:
Global Atopic Eczema Treatment Market is anticipated to grow at a robust rate during the forecast period on account of the rising geriatric population across the world and the rising number of individuals diagnosed with chronic diseases such as cardiac disorders, diabetes, and various respiratory disorders. Growth in the region is attributed to various other factors, such as increasing awareness among the population regarding their health and ever-advancing technologies that are changing the face of hospitals and medical devices.
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Stocks making the biggest moves in the premarket: General Motors, Cigna, Merck, Regeneron & more – CNBC
Posted: at 9:03 pm
Take a look at some of the biggest movers in the premarket:
General Motors (GM) The automaker reported quarterly earnings of $2.83 per share, beating the consensus estimate of $1.38 a share, helped by strong demand for trucks and SUVs. Revenue was essentially in line with Street forecasts. The shares rose 6.7% in premarket trading as of 7:44 a.m. ET.
Cigna (CI) The insurance company came in 17 cents a share above estimates, with quarterly earnings of $4.41 per share. Revenue also came in above Wall Street forecasts, helped by higher sales in Cigna's health services unit.
Merck (MRK) Merck is buying privately held drugmaker VelosBio for $2.75 billion in cash, in a move designed to boost its oncology treatment pipeline.
Regeneron (REGN) Regeneron earned $8.36 per share for its latest quarter, beating the $7.14 a share consensus estimate. The drugmaker's revenue also came in above forecasts, boosted by improved sales of drugs like eye treatment Eylea and eczema drug Dupixent.
Capri Holdings (CPRI) The company behind luxury brands like Michael Kors reported quarterly earnings of 90 cents per share, well above the 4 cents a share consensus estimate. Revenue beat forecasts as well. Strong demand in China and a surge in online sales helped drive Capri's better-than-expected quarter. The shares jumped 12% in premarket trading as of 7:44 a.m. ET.
Canada Goose (GOOS) The outerwear maker earned 10 cents per share (Canadian) for its second quarter, compared to the consensus estimate of a 3 cents per share loss. Revenue was also above forecasts as online sales jumped and as the company saw strong demand in China for its parkas.
New York Times (NYT) The newspaper publisher doubled estimates with quarterly earnings of 22 cents per share. Revenue was also above estimates, driven by an increase in digital subscriptions.
Hanesbrands (HBI) The apparel maker beat estimates by 3 cents a share, with quarterly earnings of 42 cents per share. Revenue also exceeded forecasts. Hanesbrands saw better sales for its Champion brand, and also reported an overall boost in digital sales. The shares jumped 14% in premarket trading as of 7:44 a.m. ET.
Barrick Gold (GOLD) The mining company increased its dividend by 12.5% after reporting quarterly profit that nearly tripled from a year earlier. Barrick benefited from a surge in gold prices during the quarter. The shares added 2% in premarket trading as of 7:44 a.m. ET.
Becton Dickinson (BDX) The medical products maker beat estimates by 27 cents a share, with quarterly profit of $2.79 per share. Revenue topped estimates as well. Results were boosted by a jump in sales of Covid-19 -related products like testing kits.
Qualcomm (QCOM) Qualcomm reported quarterly earnings of $1.45 per share, beating the consensus estimate of $1.17 a share. Revenue also came in above forecasts and the chipmaker gave an upbeat current-quarter forecast as Apple (AAPL) and other handset makers ramp up production of 5G phones that utilize Qualcomm chips. The shares surged 14% in premarket trading as of 7:44 a.m. ET.
Apple (AAPL) Apple is facing a shortage of power consumption chips for its new iPhone 12 line, according to people with knowledge of the matter who spoke to Bloomberg. Apple declined to comment when contacted by CNBC.
Amazon.com (AMZN) Amazon CEO Jeff Bezos sold more than $3 billion in Amazon shares in August, according to a Securities and Exchange Commission filing. Bezos has sold about $10.2 billion in shares this year, but still owns more than 53 million shares worth about $170 billion.
AstraZeneca (AZN) The drugmaker said it expected to see data from its late-stage trial involving its Covid-19 vaccine candidate later this year. AstraZeneca also reported better-than-expected quarterly sales, although profit fell short of analysts' forecasts.
Aphria (APHA) Aphria will buy craft brewer SweetWater Brewing Co. for $300 million, as the Canadian cannabis producer expands in the U.S. and enters the alcoholic beverages market.
Apache (APA) Apache reported a smaller-than-expected loss for its latest quarter, with the oil producer also accelerating cost cuts. Apache also said capital spending this year would come in at the low end of its prior forecast.
Expedia (EXPE) Expedia reported a quarterly loss of 22 cents per share, compared to forecasts of a 79 cents per share loss. The travel services company's revenue came in above estimates, even as travel demand continues to be impacted by the pandemic. The shares rose 4% in premarket trading as of 7:44 a.m. ET.
Zynga (ZNGA) Zynga lost 11 cents per share for its latest quarter, 2 cents a share smaller than analysts had anticipated. The mobile game maker's revenue above forecasts. Active user numbers rose to record levels, with its games like "Words With Friends" gaining popularity amid the pandemic. The shares lost 5% in premarket trading as of 7:44 a.m. ET.
Match Group (MTCH) Match reported better-than-expected earnings and revenue for the third quarter, as the pandemic helped boost the popularity of its dating services. Tinder, which is Match Group's most widely-used app, saw subscriber numbers jump 16% from a year earlier. The shares rose 4% in premarket trading as of 7:44 a.m. ET.
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Mothers pass on allergies to offspring – Jamaica Observer
Posted: at 9:03 pm
Sunday, November 01, 2020
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MOTHERS can pass allergies to offspring while they are developing in the womb, researchers from the Agency for Science, Technology and Research (A*STAR), KK Women's and Children's Hospital (KKH) and Duke-NUS Medical School in Singapore reported last week in the journal Science .
The study, which employed an animal model conducted according to the National Advisory Committee for Laboratory Animal Research (NACLAR) guidelines, shows that the key antibody responsible for triggering allergic reactions, immunoglobulin E (IgE), can cross the placenta and enter the foetus. When inside the foetus, the antibody binds to foetal mast cells, a type of immune cell that releases chemicals that trigger allergic reactions, from runny noses to asthma.
After birth, newborn mice develop allergic reactions to the same type of allergen as their mothers at the time of first exposure unlike adult mice, which require two exposures. Studies in the laboratory also showed that maternal IgE can bind to human foetal mast cells, indicating they might cross the placenta in humans in a similar way.
Dr Florent Ginhoux, senior principal investigator at A*STAR's Singapore Immunology Network (SIgN) and a senior co-author of the study, said: There is currently a significant lack of knowledge on mast cells that are present early on in the developing foetus. Here, we discovered that foetal mast cells phenotypically mature through the course of pregnancy, and can be sensitised by IgE of maternal origin that cross the placental barrier. The study suggests that a highly allergic pregnant mother may potentially transfer her IgE to her baby that consequently develop allergic reactions when exposed to the first time to the allergen.
Allergies begin very early in life, said Associate Professor Ashley St John, an immunologist at Duke-NUS' Emerging Infectious Diseases Programme and a senior co-author of the study. Infants experience allergic responses closely linked with the mother's allergic response in ways that cannot only be explained by genetics. This work emphasises one way that allergic responses can pass from the mother to the developing foetus, and shows how allergies can then persist after birth.
As part of the study, following NACLAR guidelines, researchers exposed mice to ragweed pollen, a common allergen, prior to pregnancy. Mice that developed a sensitivity to the pollen had offspring that also showed an allergic reaction to ragweed. The sensitivity is allergen-specific; the offspring did not react to dust mites, another common allergen.
Notably, the transfer of sensitivity appears to fade with time. The newborn mice had allergic reactions when tested at four weeks, but less or none at six weeks.
The experimental studies were backed up with cellular tests and imaging, which showed maternal IgE bound to foetal mast cells, triggering the mast cells to release chemicals in reaction to an allergen, a process called degranulation.
This study further showed that the IgE transfer across the placenta requires the help of another protein, FcRN. Mice with FcRN knocked out lacked maternal IgE attached to their mast cells, and did not develop allergies after birth.
The study findings potentially open new intervention strategies to limit such transfer to minimise the occurrence of neonatal allergies. Currently, between 10 to 30 per cent of the world's population are affected by allergies. This number is set to continue rising and a solution preventing allergies being passed from mother to child could potentially bring those numbers down over time.
Our research has really exciting findings that may explain the high incidence of early onset atopic dermatitis (eczema) in children of mothers with clinically proven eczema, which parallel findings in our local birth cohort findings, said Professor Jerry Chan, senior consultant, Department of Reproductive Medicine at KKH, senior National Medical Research Council clinician scientist, and vice-chair of research with the Obstetrics and Gynaecology Academic Clinical Programme at the SingHealth Duke-NUS Academic Medical Centre. From a clinical point of view, developing a further understanding in placental transfer of IgE, and the mechanism of foetal mast cell activation would be key to developing strategies to reduce the chance of eczema or other allergies from being transferred from mother to baby.
The authors next aim to better understand the mechanism of IgE transfer through the placenta, how IgE binding to mast cells in foetal skin modulate their functions and how it could affect skin physiology after birth.
ScienceDaily
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Adelle: I hated my body, it reminded me of my rape ordeal – Nairobi News
Posted: at 9:03 pm
Ex-Kiss FM presenter Adelle Onyango. PHOTO | COURTESY
Former Kiss fm radio presenter Adelle Onyango has revealed how she hated her body for years after she was raped.
In an Instagram post, Adelle, who was in a bikini, said she hated her body because it reminded her of her scars and her rape ordeal.
In 2008, Adelle was raped by a stranger while she was leaving a house party to hit a club in Westlands.
I am so proud of the intentional work Ive done to get to a point of loving my body. For many years I hated it. I dont know, I think at the time parts of it reminded me of getting rapedthe scars. Then came eczema with its own scars as if to mock me, she wrote.
Adelle further indicated that since the rape ordeal and the eczema, a swimming suit became a no for her for years.
Getting into a swimsuit was justa no-no! Which sucked because Ive been a swimmer all my life and I loved it! So I hid it tights, long sleeves, double sleeves, dont swim, the works! I hardly looked at it. Didnt give it the healthy things it needed. For years.yikes!
Over the years however, she disclosed, she had learnt to love her body even though it has been a long journey of healing and acceptance.
But right now I respect and honor the divinity in this body. Its carried me through battlefields and continues to do so to date. Heres to intentional healing. Its hard. It takes time. Im not all the way there. But it really is the gateway to freedom! she concluded.
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