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COMMUNITY VOICE: Of wrong horses and counterpoints | Community Voices – YourGV.com
Posted: November 29, 2020 at 5:56 am
Views expressed in community voicesdo not represent opinions of The Gazette-Virginian or staff members.
Writers need critics if for no other reason, to help us see when we have failed to communicate the main thing. The Nov. 11 and 18 editions of community voice, a response to my Nov. 4 piece on the Virginia Values Act titled Velvet covered tyranny, served that purpose for me.
So, allow me to be blunt. The Democrat-controlled legislature and Virginias executive branch are stripping your first amendment rights of free speech and religious liberty.
It does not matter if you consider yourself conservative or liberal, libertarian or progressive, or agree with me on same-sex marriage or anything else.
My critics and I are coming from such completely different worldviews that Im sure any topic I address, be it the right to life, legalized recreational marijuana, legalized gambling, etc., would provoke similar disagreement.
The point is that we have the constitutionally protected freedom not only to express those opinions in the public square but also do our jobs, run our businesses and churches, and non-profit ministries, all while following the dictates of our religiously informed consciences. The Virginia Values Act denies those rights.
Here is the second and equally important point. If a state government can strip my first amendment rights, it can strip yours. If it can deny our first amendment rights, it can revoke any of the others.
Those are the main things. But four other items need clarification.
First, I am a Christian and a pastor, not a therapist. My article, Im not gay and you probably arent either (seedaneskelton.comunder the LGBTQ category) is not an attempt at conversion therapy.
Instead, it is my testimony and invitation to any young person struggling with unwanted same-sex attraction to know that there is another way. They have the right to hear that. But if people like me are silenced, they will not hear it.
Other memoirs, like Rosaria Butterfields Secret thoughts of an unlikely convert and Dennis Jernigans Sing over me, tell similar stories and offer identical hope.
Second, regarding pushing my views and values on others, the shoe is on the other foot. I would not publicly address this issue except for two things. LGBTQ activists intend to deny all biblical Christians the rights mentioned above and have been for many years. Many sources validate that statement.
But for starters, look up Jonathon V. Lasts You Will Be Assimilated: The Same-Sex Marriage Bait and Switch, published in The Weekly Standard and Washington Examiner, June 22, 2015.
Or see lesbian conservative radio talk-show hostTammy Bruces responseto the 2014 Arizona Religious Freedom Bill, where she coined the phrase Gay Gestapo.
Third, I was happy to learn that Alliance Defending Freedom had $55M for their work. They earned Charity Navigators Platinum Seal of Transparency for 2020. I commend them to you. SeeADFLEGAL.ORG. For perspective, the ACLU, which usually argues opposite ADF, reported $202M in total assets for 2019 reporting.
Fourth, the Regnerus study I referenced has taken up too much time and was not the main point. As for its funding, You get what you pay for applies to all such research.
But it was not flawed or debunked. It was disputed and discredited by people who disagreed with the findings. But his sample size was larger than any other study of its kind at the time. Fifteen thousand people between ages 18-39. Only when the results were found politically incorrect did his department chair and others disavow it.
Heres what Regnerus said about the study in aninterview with Warren Smith. Its never been retracted. I havent retracted it. The journal hasnt retracted it. Its hard to debunk what is basically an overview snapshot of a fairly large, complex dataset. Other people analyze the data and say, Hey, Mark, its all about the instability in these families, which would be illuminating if I hadnt already said that. I said that years ago. Likely, the key variable here is the profound instability of the households in which the parents had same-sex relationships. People want to say, Oh, today its going to be Theres more of a gay or lesbian bourgeois family that will be much more stable. Its possible. I say, Show me the data. Some of this stuff well have to track for a decade or two before we get a good sense of it.
Evangelicals like me are the canary in the coalmine for America. Start paying attention to what your government is doing. Stand up for your constitutional rights. Do not stop when it gets hard and people insult you. If we fail, our freedoms are going to evaporate.
Skelton is the pastor at Faith Community Church in South Boston.
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A different kind of Thanksgiving | Local News | crossville-chronicle.com – Crossville Chronicle
Posted: at 5:56 am
Thanksgiving, so rich in memories and meaning for all Americans. In the little colony at Plymouth, in 1621, the Pilgrims had been in the New World for nearly a year. There had been springtime planting, summer watching and working, because the colonists knew that their lives depended on the coming harvest. The crops were fruitful beyond expectation and late in the fall Governor Bradford sent four men into the forest to shoot wild birds. We will hold a harvest feast of Thanksgiving he said, and invited the Indians who had been friendly to them to join them. They came bearing venison and the feast lasted for three days. This was the first Thanksgiving Day celebrated in America. As more colonists came to America the tradition of Thanksgiving Day was celebrated throughout the colonies.
General Washington gave this Thanksgiving Day proclamation in 1789: Whereas it is the duty of all nations to acknowledge the providence of Almighty God, to obey His will, to be grateful for His benefits, and favors... Now, therefore, I do recommend and assign Thursday the 6th of November next, to be devoted by the people of these states to the service of that great and Glorious Being, who is the Beneficent Author of all the good that was, and that is, or that will be; that we may then all unite in rendering unto Him our sincere and humble, thanks for His kind care and protection of the people of this country; and for all the great and various favors which He has been pleased to confer upon us.
In 1864, President Lincoln issued the first presidential proclamation appointing Thanksgiving Day as the fourth or last Thursday of November. Succeeding presidents continued the custom, and since then Thanksgiving Day has been regularly observed throughout the United States. This summary is adapted from The Book of Knowledge encyclopedia.
Yes, I admit it, Im old. Cant find any of the good old Thanksgiving poems of my days because they are all politically incorrect in these modern days. Maybe some of my old readers will remember this one by Annette Wynne, Indian Children.
Where we walk to school each day, Indian Children used to play--;
All about our Native Land, where the shops and houses stand.
And the trees were very tall, and there were no streets at all;
Not a church and not a steepleonly woods and Indian people.
Only wigwams on the ground, and at night bears prowling round--;
What a different place today, Where we live and work and play.
Gratitude by Margaret E. Sangster:
I thank You for these gifts, dear God; Upon Thanksgiving Day
For love and laughter and the faith, That makes me kneel to pray.
For life than lends me happiness, And sleep that gives me rest;
These are the gifts that keep my heart, Serene within my breast.
Love, laughter, faith and life and sleep, We own them every one
They carry us along the road, That leads from sun to sun.
May you and your families have a blessed Thanksgiving Day although it may be a little different than in years past we can love and pray for everyone even if we are unable to be together in person. God bless you all.
Old Uncle Gib is a weekly historical feature published each week. Old Uncle Gib is a pseudonym that was used by S.C. Bishop, who founded the Chronicle in 1886. Bishop actively published the Chronicle until 1948.
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I bought a 21-year-old V8 British sports car during the pandemic; it was the best thing I ever did – Telegraph.co.uk
Posted: at 5:56 am
Or clunk the stubby, hefty gearstick down a ratio and prod the throttle to hear it sing, feeling the power swell as you eke out the last few revs. For while this engine is a lazy V8 at heart, it also loves to be wrung out, rewarding you with that glorious, thudding soundtrack and an almost surprising dollop of top-end torque.
They say you shouldnt meet your heroes. But as youve probably guessed, I love this car. Its a bit of a flawed diamond, lacking the precision of a Porsche of the technical efficiency of an Audi, but making up for that with character in spades. From the moment you pop open the door using the button hidden under the mirror, of course it feels like an event.
And what about that famed reliability? Well, Ive had to call out the RAC twice although in both instancesI blame myself, rather than the car. The first time Id managed to get the seatbelt stuck; the second, I forgot to leave it plugged into the trickle chargerand the alarm system flattened the battery.
Otherwise, the TVR hasnt yet put a foot wrong in a thousand miles of motoring. Long may it continue.
Heres to good things coming out of a very bad time for the world. And to understanding wives.
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Review: ‘Sins of Sor Juana’ reveals remarkable woman – Northwest Herald
Posted: at 5:56 am
I doubt many of us have heard of Juana Ins de la Cruz, a 17th century Mexican poet and nun revered for her outspokenness. But thanks to American Players Theatre and PBS Wisconsin in their second "Out of the Woods" collaboration, I guarantee that is about to change.
De la Cruz was a legendary cultural figure in Mexico, and now is considered to be the first feminist writer in the West. Beginning her career in the court of Mexico City at the age of 16, de la Cruz addressed love, feminism, philosophy and even sex through verse at a time when it was politically incorrect, sinful, and unfashionable for women to express their intellect.
Karen Zacaras's play The Sins of Sor Juana, a Goodman Theatre season production in 2010, draws upon what little historical facts are known about de la Cruz. Zacaras writes in the style of magical realism; the play is full of imagery, drama, humor and complexity. Its also relevant and timely, appropriate for these times.
In the play directed by Jake Penner, de la Cruz is presented as an artist, a conduit through which truth is given voice. He and Zacaras address her vision quite well.
Making the virtual play reading easy to follow, stage directions are given with setting explanations; each actor is labeled onscreen, and when they speak, their box is highlighted. Voice coach Joy Lanceta Coronel wisely chose to focus on the text and not the dialects.
The play begins with de la Cruz sending a letter to the new bishop that God wants women to learn not a popular philosophy at the time. She also has managed to have a collection of her poems and sonnets published (she's dubbed the Tenth Muse of Mexico), much to the discomfort and anger of Padre Nez and Madre Filothea, heads of the convent she has taken residency in after refusing to marry the Vicereines dry and cranky Uncle Fabio. The negotiations between those two women involving writing and a library are both humorous and distressing. De la Cruz also orchestrated the death of her love Don Silvio. And now de la Cruzs actions have brought the padre and the convent before the Inquisition.
This is an ensemble that is talented, expressive both physically as well as vocally. I was engaged, and I have to admit I had a visceral reaction to some of the characters, wanting to smack the smirk off Sor Sara or shake the stupidity out of Mother Filothea.
Melisa Pereyra glows as Sor Juana Ins de la Cruz. Ive never seen so many expressions projected on a face so convincingly: determination, curiosity, confusion, hope, love, pride, beauty. Pereyra is an articulate, intelligent and vital actress.
Triney Sandoval is double cast as the Viceroy and, more magnificently, as Padre Nez, Juanas confessor and protector. Sandoval plays both parts with nobility, majestic essence, and power.
Janyce Caraballo is every bit Maria, the sweet, eager novice, so loyal to Juana. She also gets to provide the think about it ending.
Cher lvarez as Sor Sara is Juanas nemesis, the smirky gossip who quips, Youll see the charity of our actions none too sweetly. She flips the switch to also reappear as the beautiful Vicereine just pigeonhole her as the villain you love to hate.
Jeliannys Michelle is double cast as the voice of reason Xchitl and Mother Filothea. Shes flawless with her distinctive characters.
And despite not appearing long onscreen, we have Sebastian Arboleda as the questioning, loyal servant Pedro, and Ronald Romn-Melndez as the doomed Don Silvio, Juanas true love and the rogue who ignited her mind. He has the dulcet tones necessary to make his character believable.
This is a talented ensemble.
The Sins of Sor Juana is a genuinely interesting play, thought provoking, and compelling. I appreciate this introduction to de la Cruz, without a doubt a fascinating figure. American Players continues to be fascinating with its explorations of new voices through BIPOC (Black, Indigenous, and People of Color) works. I also appreciated Zacaras's incorporation of de la Cruzs poems throughout the play.
But I have to wonder how many other de la Cruzes have been ignored throughout history, or as reviewer John Olson said, How many accomplishments of which humanity has been deprived over the [centuries] by its insistence on a second-class stature for women? Well never know.
Regina Belt-Daniels is a theater veteran, having performed and directed throughout Illinois, Ohio and New York onstage, in web series and radio plays, and also serves on several theater boards. She hopes to return soon to live audiences, teaching, acting and traveling with her husband.
IF YOU VIEW
WHAT: "The Sins of Sor Juana" by American Players Theatre
WHEN: Through Dec. 31
COST: Free
INFO: pbswisconsin.org, americanplayers.org
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The 35 Best Videos of the Last 35 Years | SPIN – SPIN
Posted: at 5:55 am
SPIN launched in the peak MTV era, when an innovative or even just salacious music video could make or break an artist. Thirty five years later, YouTube is an obligatory part of any promotional push, but no ones counting on a mind-blowing clip to sell a record. (The views do often matter just not always the creativity.)
A sizable chunk of the best videos came out during the 90s alternative bloom, when directors like Spike Jonze, Michel Gondry and Hype Williams experimented with the style and substance of this malleable medium. But the format hasnt died with MTV: artists like Childish Gambino, Kendrick Lamar and Miley Cyrus all made this list for a reason and it wasnt to meet a decade quota.
Here are the top 35 from the last 35. Ready or not, here we go again. Ryan Reed
35. Guns N Roses November Rain
CREDIT: Pete Still/Redferns
Nine minutes and 16 seconds of pure theater. A song that should be considered the second coming of Stairway to Heaven was paired with a short film about Axl Rose marrying and then mourning his wife (played by supermodel Stephanie Seymour). Nearly 30 years later, does anyone know how she died? Perhaps it was during the most dramatic rainstorm in music video history, which was overshadowed by Slashs guitar playing. - Jason Stahl
34. DJ Jazzy Jeff & the Fresh Prince Summertime
CREDIT: Raymond Boyd/Getty Images
The Fresh Prince of Bel-Air takes us on a tour of Philadelphia in the Summertime video, which features one hell of a cookout. You know you wanted to be there whether it was for the fly honeys, family reunion, nostalgia or just to be a part of the happiest group of people in the city of brotherly love (who were actual friends and family of Smith and DJ Jazzy Jeff). - J.S.
33. Chris Isaak Wicked Game
CREDIT: Lex van Rossen/MAI/Redferns
Herb Ritts directed this ultra-sexy black-and-white video featuring Chris Isaac and supermodel Helena Christensen, both mostly discretely shirtless and sandy frolicking, touching and splashing around on a beach. Undeniably one of the most sensual videos of all time, it took home MTVs 1991 awards for Best Male Video, Best Cinematography and Best Video From a Film. Liza Lentini
32. Janet Jackson Nasty
CREDIT: Bertrand Rindoff Petroff/Getty Images
Listen up, all you nasty boys: Ms. Jackson makes all of her dance moves look effortless and flawless. It helps when the choreography is directed by Paula Abdul, who, by the way, makes an appearance at the 3:24 mark. But were not quite sure who decided to dress those Chicago Bears-looking fans in perv raincoats at the end. J.S.
31. Tool Stinkfist
CREDIT: Paul Bergen/Redferns
Tool guitarist Adam Jones directed this intricate stop-motion nightmare, populated by sand creatures, levitation, inaudible screams, nail swallowing, dismembered limbs, eyeless faces and mysterious tumors. The meaning of life could be embedded in the clips creepy symbols. Maybe its just super trippy. Ryan Reed
30. Weird Al Yankovic Like a Surgeon
CREDIT: Paul Natkin/Getty Images
The quote marks around his name are superfluous he was certainly then, and probably is now, a very weird fellow. He was also, at his satirical height, a very funny mimic, whose first spoof video Eat It was a masterpiece, a perfect and hysterical take on Michael Jacksons Beat It. But that came out in 1984, so it doesnt make this list, even though it just sort of did. In 1985 the comedians barbed lightning struck again, taking on Madonna and changing Like a Virgin to a nightmare realm of the gangly, curly hair helmeted and creepily mustached Yankovic as an incompetent intern at a hospital from Hell. He captures Madonnas sing-song-y pop pitch like he thought of it first; and, like her, glides and writhes and teases if that word can be so stretched to describe his perfectly Madonna-duplicating moves like a demented, alternate universe sexpot. A very alternate universe, it must be said, and one we hope is very far away. Incredibly, this recording was his second single off his third album. He was a recording star too! Bob Guccione, Jr.
29. Miley Cyrus Wrecking Ball
Miley Cyrus makes erotic videos, is sexy as heck and pisses people off. Ergo, I love her. Shes politically incorrect I now love her more and doesnt care. And, in the immortal words of David Spade, said about Lindsay Lohan, she looks like shes having fun. She also makes great pop songs and has a fantastic voice. Here, gloriously and, given her song, very literally, she rides a wrecking ball, alternatively naked and in her underwear. There is nothing wrong with this. She licks the head of a sledgehammer. I think this is meant to be metaphorical. I also think its meant to make anyone who broke up with her regret it and spend the rest of their miserable lives in unrelenting agony. The video won MTVs 2013 Video of the Year and has, to date, 1 billion and 97 million views, which would be about one seventh of the worlds population, although I suspect some people have watched it more than once. That makes it one of the most watched videos in video history. Vox Populi, baby. B.G.J.
28. Foo Fighters Big Me
CREDIT: Mick Hutson/Redferns
This jangle-pop nugget lasts just over two minutes barely longer than the ridiculously goofy Mentos commercials that director Jesse Peretz parodies here. With its numerous thumbs up shots, fourth-wall-breaking grins and outlandish silliness (like the pre-teen Foo fan outsmarting venue security and sneaking onstage with a guitar), the clip expertly zooms in on the uncanny vibe of mid-90s ads and sitcoms. R.R.
27. M.I.A. Bad Girls
CREDIT: Lloyd Bishop/NBCU Photo Bank/NBCUniversal via Getty Images via Getty Images
The idea was to compile Arabic references fantasized or not into a pop video, director Romain Gavras said of M.I.A.s joyous Bad Girls clip. Pop videos usually show American kids in their element. Here, you got Arab kids in an insane car rodeo element. Inspired by deep-dive YouTube videos of Saudis drift-driving vehicles on two wheels, the filmmaker and rapper voyaged to Morocco and staged subtly innovative scenes that flip hip-hop car clichs on their heads. R.R.
26. John Mellencamp Rain on the Scarecrow
Before the music begins, the Rain on the Scarecrow video opens with three farmers offering their unscripted distrust of how the American government is supporting or, rather, destroying the small, family-owned American farmer. The unglamorous video, a first of its kind with its stark realism, powerfully depicts Farm Aid co-founder and Indiana native Mellencamps continuing call-to-action to preserve a dying American tradition. L.L.
25. Kendrick Lamar Alright
CREDIT: Tim Mosenfelder/Getty Images
Kendrick Lamars best music videos have the same precise imagery that he uses to shape his albums and thats what director Colin Tilley and regular collaborators Dave Free and the Little Homies deliver with their black and white clip for Alright, set in the place the rapper calls home. Lamar appears free as can be throughout: freestyling with fellow Top Dawg rappers, jumping at the front of a crowd in a Compton courtyard, doing donuts with a kid passenger throwing cash and flying like a loose bill out the window. When a cops finger gun shoots him from atop a streetlamp, the screen goes black then returns to his smiling face. Tomas Miriti Pacheco
24. Fugees Ready or Not
CREDIT: Jeff Kravitz/FilmMagic
You might not expect a group named for refugees to splice A-Team-esque shots of helicopters and gunshots in the desert between their verses. But the trio slouched in the corner of a submarine is a vibe suited to the slow pressure of the song. - T.M.P.
23. Daft Punk Around the World
CREDIT: Paul Bergen/Redferns
Synchronized swimmers, gyrating skeletons, mummies wrapped in layers of bandage, robots literally doing the Robot, breakdancers with enormous torsos and tiny doll heads these are the human tools Michel Gondry used to personify Daft Punks electronic funk. The director placed these mysterious humans on a massive platform, choreographed their dreamlike movements and seemingly backed away, with his camera only occasionally switching angles. Its like spinning a colorful top and marveling at its motion. - R.R.
22. Fiona Apple Criminal
CREDIT: David Corio/Redferns
The seedy underbelly of 70s-paneled, suspiciously stained, shag-carpeted basements is the backdrop for some pretty provocative and highly controversial at the time teen debauchery, as depicted in the video for Criminal, the fifth single from Fiona Apples debut album. Part of the controversy was all of the suggestive unzipping amongst so many languid bodies, combined with an 18-year-old Apple, whos said to have written the Grammy-winning hit when she was 17, in 45 minutes. L.L.
21. Whitesnake Here I Go Again
Raise your hand if, at any stage drunk or sober after watching this video, youve attempted a cartwheel, somersault or the splits over two parked cars. [RAISES HAND] Aside from featuring two of the most gorgeous humans in music history kissing while fake-driving a car, this video is the perfect trailer for all that was great about late 80s radio rock: huge hair, big smiles and an anthemic chorus you can still blast in your car to make the moment utterly perfect. L.L.
20. Madonna Justify My Love
CREDIT: Frans Schellekens/Redferns
The Queen of Pop once ranked Justify My Love the best video from her own sprawling catalog and while we dont completely agree (see below), its impossible not to consider this erotic slice of voyeurism. Within, director Jean-Baptiste Mondino wanders through the halls and bedrooms of a very accommodating hotel, documenting snippets of sexual encounters heavy on the BDSM. MTV banned the clip, which only gave the singer a publicity boost. Not that she needed it. R.R.
19. Missy Elliott The Rain (Supa Dupa Fly)
CREDIT: Jeff Kravitz/FilmMagic, Inc
Of all her iconic music video looks, Missy shapeshifting and shimmying in a trashbag/puffer/jumpsuit reigns supreme. Its the kind of fly thats as effortless as it is dramatic. Her trademark fisheye lenses and color-coordinated green screens come together in this piece of simple genius, matching her easygoing flow and Timbalands sparse drums. T.M.P.
18. Britney Spears Oops! I Did It Again
CREDIT: Frank Micelotta/Getty Images
Britney Spears, inexplicably in space, bops around while singing apologies to her astronaut boyfriend for breaking his heart again. And no one could forget her iconic red catsuit, which officially announced to the world that the pop star is not that innocent. Mary Elisabeth Gibson
17. Radiohead Karma Police
We open inside a rickety car at night, headlights flicking on with Phil Selways first cymbal crash. Our path is a desolate road until we see the target: a man, balding and sweaty, glancing around in terror. The camera pans to the back seat, where we glimpse Thom Yorke, almost narcotically sleepy in a sharp leather jacket. He props his face on the front passenger headrest, numbly mouthing the Karma Police chorus. The target seems to be tiring, and he sputters to a stop on the dividing white line. He stands and stares with menace, and the car backs up. The target fumbles for a match in his pocket, strikes it and drops the stick onto a trail of gasoline. Flames engulf the car and eventually, we assume, the camera. But first, we cut to an empty back seat: Somehow weve lost Yorke, whos already lost himself. R.R.
16. PSY Gangnam Style
First, let me say: If fat Elvis was Korean and had real moves (not those Trumpish, fake macho poses), an Alice in Wonderland-on-acid imagination, a sublime gift for choreography and a sense of humor about himself, he might might! have been as entertaining as Psy. Left up to me (but no one listens to me) this would have been No. 1 on our list, and, in respect, I would have left spots 2 5 empty. There are more moving and important videos, sure. More artistic of course! Better songs, uh-huh, yes your point? But there has never been a better video than this. Nothing so epic. This is the Lawrence of Arabia meets The Godfather of music videos, with lapping layers of luxurious insanity and playfulness. At one point Psy is Michael Jackson doing his West Side Story knock-off, but with sexier back-up dancers and better and completely un-self-conscious dancing, and lasers. Psys trademark horse riding move is the modern equivalent of the Jackson moonwalk, but less precious, more fun and more memorable. And his underground parking lot dance-off with the Gangnam area poser in the yellow suit is simply glorious and life-affirming. B.G.J.
15. George Michael Freedom! 90
CREDIT: Mick Hutson/Redferns
Supermodels Linda Evangelista, Naomi Campbell, Christy Turlington, Cindy Crawford and Tatjana Patitz came together to lip-sync in the video for Freedom! 90, the second single from George Michaels 1990 LP, Listen Without Prejudice Vol., 1, simply because he refused to appear. The consolation is one of the most iconic videos of all time. You know that verse where Christys crawling on the floor and singing? She admitted in the 2017 documentary George Michael: Freedom that they put her in the dark because she didnt know the words. L.L.
14. Nine Inch Nails Closer
CREDIT: Tim Mosenfelder/Getty Images
Somewhere between A Clockwork Orange and Eyes Wide Shut lies NINs 1994 Closer video, which is roughly 41% sadist and 57% masochist. For the remaining 2%, we have to figure out those monkeys tied to crosses, pig heads spinning, beating hearts, ultra-real nude mannequins (or plastic-looking nudists) and Trent Reznor in bondage. Damn, those guys surely know how to make us want to be closer to Godand getting fucked like an animal is not one of them. J.S.
13. Busta Rhymes Put Your Hands Where My Eyes Could See
CREDIT: Ron Galella/Ron Galella Collection via Getty Images
Busta starts this video as a leopard-print Darth Maul, though he spends most of his time as an ancient prince touring a set equal parts Taj Mahal, Egyptian Tomb and Shaolin Temple. And thats just the lobby dip down the hallway into the spirit world for the real glow-in-the-dark body paint action. - T.M.P.
12. Jamiroquai Virtual Insanity
CREDIT: Ron Galella, Ltd./Ron Galella Collection via Getty Images
Anyone else think they were trippin watching frontman Jay Kay pull off some serious video magic as a modern-day, furniture-moving MC Esher? Or were you too distracted by his hat? Or the bugs or blood? J.S.
11. Pearl Jam Jeremy
CREDIT: Jeff Kravitz/FilmMagic)
Eddie Vedder and director Mark Pellington explore the tragedy of teen suicide in this gripping video for the turbulent Ten anthem. The massive set pieces Jeremy arguing with his parents at the dinner table; his classmates pointing and laughing, crystalizing adolescent social angst make the MTV time capsule. But Vedders less-is-more performance, seething in an empty room, is also essential to the atmosphere. R.R.
10. Fatboy Slim Weapon of Choice
CREDIT: Andrew Hasson/Photoshot/Getty Images
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The 35 Best Videos of the Last 35 Years | SPIN - SPIN
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Deep Longevity Adds Partnership with My Care Express in Merrillville To Add Biomarkers of Aging and Longevity – PRNewswire
Posted: at 5:52 am
HONG KONG, Nov. 26, 2020 /PRNewswire/ -- Regent Pacific Group Limited ("Regent Pacific" or the "Company" and together with its subsidiaries, the "Group"; SEHK:0575.HK)'s Deep Longevity, Inc, a company subject to a conditional acquisition by the Group which is a pioneer in deep biomarkers of aging and longevity today announced a collaboration with My Care Express Merrillville to deploy an extensive range of AI-powered aging clocks. Deep Longevity is to develop and provide the customized predictors of human biological age to the network of My Care Express clinicians and to provide a training program in longevity medicine.
Deep Longevityaging clocks are supported by a number of academic publications summarized in a recent review titled "BioHorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities"
My Care Express Merrillville has been a provider of preventative and total health care to its patients since it opened. My Care Express has a unique approach to wellness and longevity by helping patients establish wellness goals to live happier, healthier and longer lives. Deep Longevity and My Care Express will partner to see the impact that the utilization of aging clocks has on their patients. "We have always believed that the more information our patients have regarding their health, the better choices they will make. We believe that implementing aging clocks will give our patients a better understanding of their current health and help them achieve their wellness goals", said Dr. Faiz Shareef.
In the scope of the partnership My Care Express physicians will be trained in deep aging clocks and will be able to provide their customers with AgeMetric reports and engage in advanced research to assess the performance of aging clocks in the context of their wellness journey.
"The traditional approach to preventative medicine is focused on preventing disease by diagnosing the symptoms early or reducing the risks of disease. The AI-guided longevity medicine goes much further than that and is focusing on tracking the person's rates of aging at many levels, identification of longevity bottlenecks, and utilizing the latest advances in science and technology to slow down or reverse biological and psychological aging. We are very happy to have My Care Express join the rapidly growing network of our research and clinical partners focused on providing customers with extra years of productive and happy life", said Alex Zhavoronkov, Chief Longevity Officer of Deep Longevity Inc.
About Deep Longevity
Deep Longevity is subject to a conditional acquisition by Regent Pacific Group Limited (SEHK:0575.HK), a public company whose securities are listed on The Stock Exchange of Hong Kong Limited. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down, or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS) solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Originally incubated by Insilico Medicine, Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other experts AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers.
About Regent Pacific (SEHK: 0575.HK)
Regent Pacific is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness, and life sciences sectors. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering.
About My Care Express Merrillville
My Care Express Merrillville is a clinic in Northwest Indiana that provides primary and urgent care with a focus on preventative medicine. My Care Express believes in a proactive approach to healthcare by providing its patients with tools that will help them live longer healthier lives. Located on the border of Indiana and Illinois, My Care Express has a dynamic and diverse practice. For more information visit mycareexpressclinic.com
SOURCE Regent Pacific Group Limited
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Unravelling the holy grail of anti-ageing and longevity – The Business Times
Posted: at 5:52 am
GOOD nutrition, clean environments, accessibility to good healthcare and healthy lifestyles have increased human longevity. Nevertheless, the quest of increasing longevity is insatiable. As medical science pushes the boundaries of human lifespan, delving into the science of longevity can help us sieve through the reams of information and distil the essence of anti-ageing and cell preservation.
Cellular ageing
Cell ageing or cellular senescence is a physiological state with permanent cessation of the ability of the cell to replicate and accumulation of damaged DNA ( basic building blocks of genes), and this process is increased by ageing. This cellular senescence is marked by shortening of the protective terminal ends of the chromosomes which are called telomeres.
Telomeres are like plastic caps at the ends of shoelaces, preventing them from being frayed and damaged. Shortening of the telomere is a sign of cellular senescence.
In 1979, the first of the SIR (silent information regulator) proteins or sirtuins was reported. Over time more members of this protein group were found. In 1999, the publication of a study that reported that increased sirtuin activity could increase the lifespan of yeast cells by 70 per cent heralded a major breakthrough that accelerated the interest and research in sirtuins.
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Since then, there has been a growing body of evidence that the cell has a group of anti-ageing proteins, the sirtuins, that are essential for delaying cellular senescence and increasing the lifespan of organisms.
Anti-ageing proteins
Core to the science of anti-ageing is this group of proteins called sirtuins. In human cells, there are seven sirtuins (SIRT 1 to 7) with various roles within the cell. Three of these sirtuins (SIRT 3,4,5) control the generation of power for the needs of the cells and function in the mitochondria (power generator which produce the energy for the needs of the cell) with roles in cellular antioxidant balance and lipid metabolism.
Another three sirtuins (SIRT 1, 6, 7) control the genetic framework in the cell and function in the cell nucleus (the central core of the genetic material in the cell) with roles in gene expression and DNA repair. There is one sirtuin (SIRT 2 mainly) which control the environmental processes within the cell and function in the cytoplasm (the liquid content within the cell).
As an analogy, if the cell is a factory, the sirtuins are the executive management of the company directing and controlling all the aspects of the cell's activities. They play important roles in maintaining the integrity of the cellular genetic structure, keeping the genetic material (chromatin) in a "wound up" protected state to reduce damage and in repairing damaged DNA.
Mechanisms of action
The main mechanisms of suppression of cellular senescence by sirtuin activity is via the actions of preventing telomere shortening or attrition, and promoting the repair of damaged DNA.
Many proteins in the cells have a chemical tag called an acetyl group attached to it. One of the key ways in which sirtuins work is by the removal of the acetyl group from other molecules or proteins, thereby affecting the activity of the protein. This action has significant impact on the control centre of the cell, namely the activity of the genetic material or chromatin.
The basic building block of the genetic material, the DNA, is wrapped around groups of proteins called histones allowing the genetic material (chromatin) to be packed more compactly.
When the histone protein has the acetyl group chemical tag , it causes the chromatin to be partially unwound and hence exposing the unwound DNA to be copied, thereby allowing the gene instruction to be passed to another cell or protein. As an analogy, it is as if a door to the office is opened and people are allowed to go into the office to copy instructions which are then passed to other offices.
Once all the instructions are copied, the office door is closed. Hence, once the task is completed, the chromatin will not remain unwound as it will be more vulnerable to damage if it remains open.
Subsequently, the sirtuins can then remove the acetyl group from the histones which will then allow the chromatin to be closed by being "wound up" tightly, preventing DNA material from being copied and in effect silence the gene.
Besides histones, sirtuins target other non-histone proteins such as proteins involved in copying genetic information and proteins that are involved in the repair of DNA. They are also known to regulate the production of the enzyme telomerase which is required for telomere elongation and maintenance of the integrity of the telomere.
Most human cells have insufficient telomerase and hence there is progressive shortening of the telomere which is strongly indicative of progressive cellular ageing. Elongation of the chromosomal telomere is tantamount to reversing the biological clock.
Beneficial effects of sirtuin activity
Studies have shown that sirtuins have roles in the regulation of copying of gene information, modulation of energy production, prolongation of cell survival, reduction of DNA damage, reduction of cell damage and prolongation of longevity. Increased sirtuin activity in mammals has been associated with a delayed onset of age-related diseases and an increase in longevity.
Sirtuins appear to be able to inhibit axonal (nerve fibre) degeneration, a process that often precedes the death of nerve cells as seen in neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
It may also have protective effect on nerve cells, reducing processes that lead to the death o f nerve cells and the development of Alzheimer's disease.
Loss of sirtuin activity has been implicated in the development of cardiovascular and metabolic diseases including degeneration of arteries, acute damage to the heart muscle, thickening of the heart muscle, abnormal heart rhythms, high blood pressure, obesity, diabetes mellitus and abnormal lipid levels. While most of the studies have been done in animals, there is an increasing number of human studies.
There is presently an increasing body of evidence that shows increased sirtuin activity is indispensable for delaying cellular senescence and appears to protect the body against many age related diseases. In addition, studies support the role of sirtuins as anti-aging agents and potentially prolong longevity.
Hence, lifestyle, dietary and pharmacological choices that increase sirtuin activity can potentially increase the anti-ageing effects and prolong longevity. These will be discussed in the next article where we will examine how we can make better decisions to increase our quality of life and lifespan.
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Unravelling the holy grail of anti-ageing and longevity - The Business Times
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Longevity and Anti-senescence Therapy Market size and Key Trends in terms of volume and value 2020-2025 – Express Journal
Posted: at 5:52 am
The recent report on the Longevity and Anti-senescence Therapy market predicts the industrys performance for the upcoming years to help stakeholders in making the right decisions that can potentially garner strong returns. Further, the document provides comprehensive analysis of the key industry trends as well as the opportunities that will ensure an upward growth trajectory in the coming years. It also focuses on developing strategies for challenges faced by the industry. Moreover, an exhaustive discussion of the latest updates including the impact of COVID-19 pandemic is furnished in the study.
Key highlights from COVID-19 impact analysis:
An overview of the regional landscape:
Request Sample Copy of this Report @ https://www.express-journal.com/request-sample/268954
Other important takeaways from the Longevity and Anti-senescence Therapy market report:
Key aspects listed in the report:
Points Covered in The Report:
The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors, etc.
The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. The historical data and forecast data from 2020 to 2025.
The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.
Data and information by manufacturer, by region, by type, by application, etc., and custom research can be added according to specific requirements. The report contains a SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.
Recent Industry Trend:
The report contains the profiles of various prominent players in the Global Longevity and Anti-senescence Therapy Market. Different strategies implemented by these vendors have been analyzed and studied to gain a competitive edge, create unique product portfolios and increase their market share. The study also sheds light on major global industry vendors. Such essential vendors consist of both new and well-known players. Besides, the business report contains important data relating to the launch of new products on the market, specific licenses, domestic scenarios and the strategies of the organization implemented on the market.
MAJOR TOC OF THE REPORT:
Chapter 1 Industry Overview
Chapter 2 Production Market Analysis
Chapter 3 Sales Market Analysis
Chapter 4 Consumption Market Analysis
Chapter 5 Production, Sales and Consumption Market Comparison Analysis
Chapter 6 Major Manufacturers Production and Sales Market Comparison Analysis
Chapter 7 Major Product Analysis
Chapter 8 Major Application Analysis
Chapter 9 Industry Chain Analysis
Chapter 10 Global and Regional Market Forecast
Chapter 11 Major Manufacturers Analysis
Chapter 12 New Project Investment Feasibility Analysis
Chapter 13 Conclusions
Chapter 14 Appendix
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Longevity and Anti-senescence Therapy Market size and Key Trends in terms of volume and value 2020-2025 - Express Journal
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Genomic Biomarker Market Research Report 2020 with Business Overview and Manufacturers Profiles till 2026 – Cheshire Media
Posted: at 5:50 am
The Genomic Biomarker Market grew in 2019, as compared to 2018, according to our report, Genomic Biomarker Market is likely to have subdued growth in 2020 due to weak demand on account of reduced industry spending post Covid-19 outbreak. Further, Genomic Biomarker Market will begin picking up momentum gradually from 2021 onwards and grow at a healthy CAGR between 2021-2025
Deep analysis about market status (2016-2019), competition pattern, advantages and disadvantages of products, industry development trends (2019-2025), regional industrial layout characteristics and macroeconomic policies, industrial policy has also been included. From raw materials to downstream buyers of this industry have been analysed scientifically. This report will help you to establish comprehensive overview of the Genomic Biomarker Market
Get a Sample Copy of the Report at: https://i2iresearch.com/report/global-genomic-biomarker-market-2020-market-size-share-growth-trends-forecast-2025/#download-sample
The Genomic Biomarker Market is analysed based on product types, major applications and key players
Key product type:OncologyCardiologyNeurologyNephrology
Key applications:HospitalsDiagnostic and research laboratories
Key players or companies covered are:Bio-RadBeckman CoulterMyriad GeneticsThermo Fisher ScientificRocheQIAGENEpigenomicsAlmacPfizerHuman LongevityValiRxPersonalisEagle GenomicsEmpire GenomicsAgilentIllumina
The report provides analysis & data at a regional level (North America, Europe, Asia Pacific, Middle East & Africa , Rest of the world) & Country level (13 key countries The U.S, Canada, Germany, France, UK, Italy, China, Japan, India, Middle East, Africa, South America)
Inquire or share your questions, if any: https://i2iresearch.com/report/global-genomic-biomarker-market-2020-market-size-share-growth-trends-forecast-2025/
Key questions answered in the report:1. What is the current size of the Genomic Biomarker Market, at a global, regional & country level?2. How is the market segmented, who are the key end user segments?3. What are the key drivers, challenges & trends that is likely to impact businesses in the Genomic Biomarker Market?4. What is the likely market forecast & how will be Genomic Biomarker Market impacted?5. What is the competitive landscape, who are the key players?6. What are some of the recent M&A, PE / VC deals that have happened in the Genomic Biomarker Market?
The report also analysis the impact of COVID 19 based on a scenario-based modelling. This provides a clear view of how has COVID impacted the growth cycle & when is the likely recovery of the industry is expected to pre-covid levels.
Contact us:i2iResearch info to intelligenceLocational Office: *India, *United States, *GermanyEmail: [emailprotected]Toll-free: +1-800-419-8865 | Phone: +91 98801 53667
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Microbiome Therapeutics Market: What’s the Future Potential? Roots Analysis – Cheshire Media
Posted: at 5:50 am
Roots Analysis has announced the addition of Microbiome Therapeutics Market, 2015-2030 report to their offering. The report provides a comprehensive study on the current landscape and the future outlook of the evolving pipeline of products in this area. While the field has garnered the interest of several companies, there are no approved microbiome drugs available in the market yet; Faecal Microbiota Transplant (FMT) is the only commercially available procedure till date. However, the development pipeline of microbiome therapeutics has several promising candidates that are likely to result in commercial success stories in the foreseen future.
Ishita Nanda, the principal analyst, said, Among other elements, the report also elaborates on new microbiome based diagnostic solutions being developed and the upcoming opportunities in this market for different stakeholders.One of the key objectives outlined for this report was to understand the future potential of the market. This was done by analyzing:
Nanda added, The study provides a detailed market forecast and opportunity analysis for the short-mid term (2015-2022) and long term (2022-2030). Our opinions and insights, presented in this study, were influenced by several discussions conducted with experts in this area. These included senior representatives at Assembly Biosciences, Da Volterra, Metabiomics, MicroBiome Therapeutics and Rebiotix.
The 218 page report includes detailed profiles and an assessment of the microbiome therapeutics programs of many companies including:
Details of some other firms developing microbiome related diagnostics and companion diagnostics have also been captured. Examples include (in alphabetical order) Admera Health, Biocartis, Enterome Bioscience, Human Longevity, Metabiomics, Microbiome Diagnostics, Viomer, Whole Biome.
For additional details, please visithttp://www.rootsanalysis.com/reports/view_document/microbiome-therapeutics-market-2015-2030/117.htmlor email[emailprotected]
About Roots Analysis
Roots Analysis is a specialist market research company, sharing fresh and independent perspectives in the bio-pharmaceutical industry. The in-depth research, analysis and insights are driven by an experienced leadership team which has gained many years of significant experience in this sector. If youd like us to help you with your growing business needs, get in touch at[emailprotected]
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Microbiome Therapeutics Market: What's the Future Potential? Roots Analysis - Cheshire Media
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