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Category Archives: Transhuman News

The allure of interconnection – Oregon ArtsWatch

Posted: December 8, 2020 at 3:08 am

When were stuck inside, we crave the outdoors. Youve probably noticed it this year, too. Its been easy to compartmentalize nature as a singular entitywere either in it or were notand it feels quite distant during pandemic times. But perhaps our relationship to nature could become more fluid, more interconnected, more spiritual. Such is the central topic of Adams and Ollmans group show, Eartha, featuring the works of seven artists grappling with their place in the natural world. The exhibition successfully creates openings and liminal spaces, encouraging deeper thought on human-flora-fauna relationships.

Eartha includes fifteen artworks, primarily paintings with a few pastel works on paper in the mix. The works are split between Adams and Ollmans back gallery room and their office space. The small gallery room, occupied by a few people comfortably, grants an intimate feel to the viewing experience. One feels enveloped by artworks in a small space. Likewise, the paintings installed in Adams and Ollmans office area integrate with books, a desk and chair, pottery; these functional objects deepen a sense of relationship between the art on display and daily life.

In the gallery room, Amy Bays trio of textural floral paintings feel like homages to all things decorative, patterned, and lush. Each has a zoomed-in quality. Flowers explode from all sides, occupying each paintings entire frame.

Across from Bays paintings, Ann Cravens Moon (Pink Crescent, Cushing, 8-25-19, 1:30AM) is a simple rendering of a luminous pink moon, part of Cravens extensive lunar painting catalog dating back to 1995. The painting has an immediacy and purity, settling well alongside the other pieces in the room.

Maureen St. Vincents Three Stacks and a Rock, a soft pastel drawing on paper with a custom frame, brings in more ambiguity and space for interpretation. The drawing isolates three rocky bluff vignettes as viewed through oval openings, reframing the landscapes both literally and conceptually. The openings feel fleshy, perhaps hinting at the bodys relationship to the natural world, or the body as navigable terrain. Three holes in St. Vincents custom frame create a balanced absence against the three openings in the pastel drawing.

While each work in the gallery room hones in on natures openness to interpretation, the standout pieces are Hayley Barkers Beverlywood and Riverwood. Barkers mark-making finds equilibrium in a space between gesture and intention, abstraction and representation. The works feel like recognizable landscapes, but not quite, as though Barkers compositions were pulled from a dream. Unexpected, bright color-pops mingle among neutral tones. Beverlywood is more impressionistic, while Riverwood has a more traditional landscape composition. In Riverwood, Barker plays with reflection and renders an astronomical body, but her color choices still make the scene feel surreal. Side-by-side, the two paintings conjure a sense of peering into an alternate world.

Moving into Adams and Ollmans office, the first paintings I spot are Kaila Farrell-Smiths Get Out NDN and Under Fire. Farrell-Smith employs traditional Indigenous aesthetics and abstraction to explore landscapes between Indigenous and Westernized worlds. Farrell-Smith is also the sole artist in the show to utilize text in her work; I spot the word HUMAN in both paintings, and MAKLAK in Get Out NDN. The paintings have an intensity that causes one to stop and stare at the abstract lines and jagged scribbles. A black and white palette alongside neon orange and green demonstrates the artists fearlessness. Although its difficult to come to a precise conclusion from viewing the paintings, urgency is embedded in the works.

Further back in the office, another Amy Bay painting, My Condolences, and a second Maureen St. Vincent piece, Untitled, are installed across from each other. Both pieces expand further on themes the artists raised in their other works on display; St. Vincents Untitled is even more bodily than Three Stacks and a Rock, with undulant shapes and suggestions of pubic hair and flesh. Bays My Condolences is framed by ultra-thick paint dabs begging to be touched. I wonder if these works could have been displayed more prominently. Installed far back in the office, they dont feel as though theyve been given adequate attention.

Mariel Capannas paintings embed a wealth of information onto small canvases. Two of Capannas paintings, Hose, Bow, Flowers, Trumpet, Duck and Flowers, Fountain, Six oclock contain thick, blocky shapes coalescing to become detailed outdoor scenes. Cars, palm trees, ladders, umbrellasall slowly emerge the longer one gazes at these dense scenes. Its no surprise that Capanna sources imagery from films, documentaries, found photos, and home videos. A playful, game-like quality to the works turns the viewing experience into a search-and-find.

Conversely, Capanna shows her depth by switching it up in Candles, Flowers, Flowers, Chair. This painting is far quieter, with delicate flowers and candles floating cloud-like against a backdrop of sky. Capanna plays with notions of time in nature, creating visual representations of speed and slowness.

While Hayley Barkers paintings stood out in the gallery room, Emma Cooks monochromatic painting The Pig and the Cat is most striking in the office space. Against a background of dark crisscrossed lines, Cook paints a diverse range of characters pulled straight from a folkloric fantasy. Anthropomorphized pigs, figures with devilish grins, and abstracted creatures surround the paintings edges and meet in the middle, furthering a storytelling effect. The result is subtly unsettling, hinting at exploitative histories.

Eartha provokes more questions than answers, and perhaps thats one of the exhibitions goals. What potential for transformation exists in our relationship with the natural world? How does the body navigate natural spaces when considered through lenses of gender, politics, colonization, and spirituality? Each artist in Eartha answers the question in their own way. This openness to a wealth of answers helps prompt an ongoing conversation to begin.

Eartha is on view at Adams and Ollman (418 NW 8th Ave) through December 19th. The gallery is open by appointment only.

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The Costs of Colonization: Cleverman as an Anti-Western – tor.com

Posted: at 3:08 am

There are hundreds of Westerns, but virtually none which center Native American stories or perspectives. Some movies, like John Fords The Searchers (1956) or the Kevin Costner vehicle Dances With Wolves (1990), acknowledge the history of violence against Indigenous people, and include native characters or storylines. But these films still feature white stars, and view native people primarily through white eyes. This is so consistent, and so ubiquitous, that the Western as a genre could even be defined as narratives about the American West presented from the point of view of colonizers.

Space westerns have a more abstract relationship to the actual American West, but the tropes are much the same. The Mandalorian and Star Trek ask viewers to identify with explorers and pioneers, not with the explored and pioneered. Movies like Outland are as white as their Western predecessors, set in a landscape pre-emptied of Indigenous people. There are only white people in spacejust as, in Westerns, there are often, counter-historically, only white people in America.

The 2016-2017 Australian independent television series Clevermanisnt an exception to the colonial perspective of space Westerns, primarily because it isnt a Western. Instead, it can be seen as a kind of anti-Western. By focusing on the stories of Indigenous people, it turns Western genre pleasures inside-outand shows why those pleasures are only possible when you strap on the colonizers gunbelt.

Cleverman is a quasi-superhero narrative set in a future dystopia in which an Aboriginal race, the fur-covered, superstrong Hairypeople, live in uneasy coexistence with humans. Most Hairypeople are confined to a ghettoized neighborhood called the Zone, which is heavily policed by patrols and high-tech surveillance equipment. The hero of the series is a half-Gumbaynggirr man named Koen West (Hunter Page-Lockhard) who discovers that he has the invulnerability and powers of the Cleverman. He tries to use his abilities to protect the Hairypeople from their human oppressors and to thwart his ambitious, envious brother Waruu (Rob Collins.)

Its not surprising that Cleverman never became a hit series. Creator Ryan Griffin used Aboriginal legends and stories as inspiration, and while the mythology is fascinating, it strikes less of a chord with international audiences than more instantly familiar, corporate superheroes or the ubiquitous iconography of Westerns. Its determination to be true to Indigenous experience made it virtually impossible for the series to reach a truly mass audience.

Cleverman is also just a bleak, downbeat show. The Hairypeople lived on the land before humans came, but now they are hemmed in, pinned down, imprisoned and hounded to death. Like actual Indigenous people, the Hairypeople are penned into squalid reservations, thrown into prisons, and trafficked into brothels. The humans demand they abandon their culture and their powers; one of the only ways out of the Zone for the Hairypeople is for them to agree to be injected with a formula that robs them of their fur and their strength. The Zone is crowded and miserable, but if the Hairypeople try to move into property outside the Zone, they are arrested.

Watching Cleverman can be an intense, difficult, and claustrophobic experience. The Hairypeople are penned in both by walls and by history. The show is science fiction, but reality clutches at the narrative like fingers around a throat. The humiliations and the violence that the Hairypeople suffer all have real-life precedents. Colonizers kill children; they put people in prison and beat them; they rape. The experience of colonization is an experience of restriction: The Hairypeoples lives are a shrinking circle. They are being crushed out of existence.

Colonization means constriction for the Hairypeople. But for their tormentors, it means freedom, and more room to expand. This is most obvious in the storyline of Jarrod Slade (Iain Glen), a wealthy white Australian who is studying the Hairypeople in order to appropriate their powers for himself. He manages to create a serum which gives him Hairypeople strength, endurance, and speed, allowing him to leap across the Sydney cityscape with exuberant glee.

Again, this isnt a Western. But Slade stepping on Indigenous people to boost his way into his own freedom and self-actualization is nonetheless an instructive dynamic. The allure of the Western, and the space western, is a sense of freedom and powerof breaking out of the dreary, normal, everyday grind of mundane business and lighting out for the territories. The Starship Enterprise or Millennium Falcon zipping across the screen has the same allure as Clint Eastwood riding off into the sunset. The joy is in the feeling that youre headed somewhere new and big and empty, where rules do not apply. Like the tourists in Michael Crichtons Westworld, fans of the Western get to take pleasure in a fantasy of shooting and screwing and swaggering with no consequences and no restrictions.

Cleverman is a valuable reminder, though, that opening up the frontier for one person often means closing it down for someone else. You can ride where you will in that vast and empty landscape only because someone forcibly emptied it out, and tossed its original inhabitants into the Zone. John Wayne and Han Solo and Captain Kirk are indomitable and larger than life for the same reason that Slade is: Theyve stolen someone elses spirit, and injected it into their own veins.

This isnt to say that Westerns arent fun. Its to say the opposite. Westerns, and space westerns, are really fun! Freedom, empowerment, discovery, shooting the bad guys down: those are enjoyable fantasies. People like them, and for good reason. But its sometimes worth considering whats left out of a genre as well as whats in it, and to think about what truths we clear away when we make room to enjoy ourselves. A space western that really centered and gave weight to Indigenous experiences wouldnt be a space western anymore. Instead, like Cleverman, it might be a dystopia.

Noah Berlatsky is the author ofWonder Woman: Bondage and Feminism in the Marston/Peter Comics(Rutgers University Press).

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Is humanity ready to live in space? – Sciworthy

Posted: at 3:08 am

The settling of distant planets and solar systems has started to be more than just a dream of the scientific community. When considering projects that span across millennia, incentives for space exploration that forego short term benefits in the interest of long term results may be the most successful approach.

In the field of exploration, space remains by far the costliest in both time and money. Given the recent expansion in space exploration to include private companies and the increased interest in manned missions to mars and the moon, humanity may well become a multiplanetary species in the future. When realizing these distant goals such as space settlements and space colonization, it is important to consider that the settling of space might only be possible across generations. In Jacob Haqq-Misras paper, Can Deep Altruism Sustain Space Settlement, Haqq-Misra delves into this topic and explores strategies that can be pursued in order to make possible a multigenerational approach to space settlement.

Potential strategies considered are deep altruism and deep egoism. Haqq-Misra considers deep altruism to be the more effective approach. Deep altruism can be considered the pursuit of long-term goals deep in the future (spanning millennia) without consideration for any short term benefits. Deep egoism, on the other hand, can be considered the antithesis to deep altruism, it is the pursuit of long-term goals for the financial benefit of the founding parties, or their descendants.

In order to determine the efficacy of deep altruism in long term space settlement, Haqq-Misra begins with the example of the time capsule. Time capsules are long term efforts to communicate with future societies. Because of their minimal benefit to the groups producing the time capsules, they can be considered altruistic in intent. Time capsules can be left from a short duration of several years to longer periods of hundreds of years. When time capsules are planned to last for periods stretching into thousands of years, it is important to design them so future generations understand the contents of the time capsule.

Haqq-Misra goes on to break down long term human projects into a hierarchical relationship between information, structure and culture. Cultural projects typically involve the preservation of tradition and culture of a society, structural projects are done to preserve buildings and engineering accomplishments, and information projects archive knowledge such as solutions to problems.

He then describes and compares generational versus intergenerational time scales, introducing the concept of deep time.Generational time typically involves a project that is started and completed within one generation. The founder of the project sees it come to fruition and reaps the benefits, such as the Human Genome Project. Intergenerational time involves projects that run between 100 and 1000 years. With intergenerational time, the founder of the projectmay not live to see the benefits, but their descendants usually will see the benefits. These projects usually have an impact on the same culture that was around when the project started. Deep time involves projects that take over 1000 years to complete. Examples would be Stonehenge or the Great Wall of China. These projects are far less common and are rarely pursued, as the undertaking of such projects can require massive investment at start. Also, with deep time, founders and their descendants will not see any benefits from the end results of the project. For this reason, projects that extend into deep time tend to be altruistic in nature we do it for some greater good.

In evaluating whether or not humanity is ready to set out on the long journey of settling space, Haqq-Misra first analyzed the incentive structure of the world. With its current predominantly capitalistic societies, Haqq-Misra acknowledged that one potential option to finance humans settling space would be deep egoism. Deep egoism is a system where space ventures could turn massive profits and thus finance future expeditions and settling. However, deep egoism poses a risk of failure if financial ventures fail to continually provide a return on investment. So, deep altruism is the most viable option to guarantee the success of long-term missions. Deep altruism, however, can only be achieved through government and private enterprise intervention, and although deep egoism can certainly assist in the process, it will be deep altruism that will allow for long term settlements in space.

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Monetizing the Final Frontier – The New Republic

Posted: at 3:08 am

History, of course, would suggest that treaties crumble when serious money comes into play. Western settlers signed treaties with indigenous people in the Americas, then ignored them, as Lucianne Walkowicz, an astronomer at the Adler Planetarium and another cofounder of the JustSpace Alliance, noted.

In many cases, she told me, treaties are good until somebody discovers something that they want. Shes a fan of the Outer Space Treaty, finding it a very, like, hopeful, peaceful, almost Star Trek-esque view of what space is. She hopes it proves stronger than it looks.

Historically, however, law tends to follow the facts on the ground rather than shape them. When a new geography for commerce opens, whoever shows up first to exploit the resources sets the normand then law is written to validate the first movers. First come, first serve is essentially whats going to happen when people start to do things on the moon, Peter Ward, author of The Consequential Frontier, said.

Yet before the great water rush on the moon starts in earnest, one key point is worth pausing over: The supply of ice on the moon is limited. The estimated water reserves up there may be eye-popping at first glance, but theyre not that big. They likely add up to three to five cubic kilometers of water, based on the studies that have come up, said James Schwartz, a philosopher who also studies the ethics of space exploration. Not a lot of water compared to even moderate- or small-size lakes on Earth. It wouldnt be that hard for a concerted explosion of commercial activity to chew through it all.

That may sound far-fetched, but, as all these space ethicists note, to the eyes of nineteenth-century explorers and industrialists, our planet seemed limitless, tooand it only took another century-plus of rapid commercial activity to tear through a diminishing store of finite resources. The environmental implications of exhausting the moon seem ludicrously sci-fi and far-off right now, and theyll remain so for a long timeuntil, abruptly, theyre not. As with low-Earth orbit, outer space becomes much smaller and more cramped when you start thinking at commercial scale.

In any event, the moon is chiefly envisioned as a way-station project among the most ambitious cohort of space privatizers. A settled moon colony would serve as the push-off point for the main event, commercially speaking, for New Space entrepreneurs: mining the asteroid belt.

Asteroids are almost comically rich in precious materials. The asteroid Ryugu, for example, has about $82 billion in nickel and iron, according to the Asterank asteroid-valueranking project. Another, Bennu, boasts a cool $669 million worth of iron and hydrogen. You could totally collapse the gold and platinum market on Earth by mining asteroids, joked Jacob Haqq Misra, a senior research investigator with the Blue Marble Space Institute of Science, a nonprofit that encourages space exploration.

But theres a hitch: Nobody has much of an idea how youd actually mine an asteroid. Despite what youve seen in lumbering sci-fi epics like Armageddon, merely grabbing hold of a comparatively small, city-blocksize object in microgravity is a forbidding physics puzzleto say nothing of actually refining whatever you find.

One things clear, however: In order to reach an asteroid, youd need a lot of fuel for robotic probes. (Oxygen, too, if youre bringing along a human crew.) This would likely be too expensive to do from Earth, given its gravity. The moon, on the other hand, is a sweet spot to base ones commercial mining endeavors: enough gravity so humans can live in a base and assemble a rotating corps of mining robots, but sufficiently little gravity that launching mining probes at asteroids is easy.

It takes so much energy to escape Earths orbit, by the time you do that, youre basically halfway to anywhere in the universe, Anderson said. The moon as a launchpadtheres a lot of commercial value there.

Some New Space firms harbor still greater plans, in line with the classic civilizing mission that animated so many colonial land rushes in recent terrestrial history. Jeff Bezos wants to build space stations that rotate fast enough to simulate Earth gravityand large enough to host entire cities full of residents. Its a vision he built from a youth steeped in sci-fi. At Princeton, he took a class with Gerard ONeill, a physicist whod been arguing since the 1960s that humanity had to slip the surly bonds of Earth in order to survive over the long haul. ONeill argued that living in space and mining asteroids represented the only path forward for the human race to continue growing and prospering without laying waste to planet Earth. He laid it out as a simple proposition of geology: If you were to mine the entire Earth down half a mile, leaving it a honeycombed crater, youd still only get 1 percent of the metals and substances from the three biggest asteroids.

Bezos has eagerly endorsed the space-colony vision. In the short term, Bezoss plans are the standard-issue vision for the New Space entrepreneur: building rockets and spacecraft that NASA will hire in order to resume landing astronauts on the moon. But in the long rundecades hencebuilding space colonies is, as he has argued, the only mission he can find big enough to devote his life and riches toward. The only way that I can see to deploy this much financial resource, Bezos told Business Insider, is by converting my Amazon winnings into space travel.

The unexpected costs of Bezos-style space exploitation are, as yet, a little distantdecades, at least. But if theres one thing weve learned from observing the human and environmental wreckage of the industrial era, its that history is like space travel: The path you set at the beginning is critical. Changing course later on is much harder. So it behooves us to plan now. Are there ways to avoid the worst possible outcomes in space? How is commercial life in space going to unfold?

The worlds small community of space ethicists has, in recent years, been increasingly pondering this, and theyve come to some unsettling conclusions. First off, they note, the big winners in space will likely be ... the big winners on Earth. I think its going to benefit the wealthy people that are running these mining firms, Schwartz said bluntly. There are, as New Space investors today will tell you, winner-take-all dynamics. Bezos built a supply chain that is helping Amazon gradually dominate the world. Space will probably have room for only a few winners. So in order to envision the future contours of space conquest, its probably a safe bet to take all the harms of monopoly we see on this planet and project them on to a literally cosmic scale.

And that leads, in turn, to a corollary prophecy: Human rights in space are likely to be execrable, if theyre left up to the private sector.

Consider that anyone working in space will be reliant upon their employer for the most basic stuff of life. Thats not just food and water, but breathable oxygen, on a minute-by-minute basis. Plenty of science fiction has, over the years, war-gamed the bleak implications of these precarious situations. In Ridley Scotts Alien (1979), the employees of The Company are sent unwittingly to encounter a vicious alien life-form, with The Company hoping it would get a profitable specimen out of this. More recently, the TV show The Expanse depicts the lives of asteroid miners as an outright form of slavery. One could, again, regard this as the typical pessimism of left-wing creative typesuntil one ponders workers rights on Earth as they exist now. Employees in Amazons warehouses are already peeing into bottles and collapsing from heat exhaustion in their attempt to satisfy their employers relentless work quotas; imagine if the company also controlled their breathable air.

Charles Cockell is a professor of astrobiology at the University of Edinburgh whos written at length about the question of freedom in space settlements. Hes generally a libertarian, so hes concerned about concentrations of power in both governments and private-sector firms in space.

The controls on freedom of movement on the moon or Mars are worse than in North Korea, he told me. You cant just walk out of a settlement. Control of oxygen, he predicted, will empower the worst instincts of authoritarians of any stripe. It will attract the coercively inclined and petty officialdom like all these things do. It will attract people who crave power. You have to assume that that will lead to tyranny.

These thought experiments dont all conclude in grim dead-ends, however. Theres a whole arm of space ethics and philosophy devoted to asking the questions: Could the prospect of settling space positively serve society and justice? Could it offer up new ways of thinking about how we organize civic relations?

Coping with scarcity in space might impel settlers to reconsider some of the basic tentpoles of Western society. One is prison: On Mars, jailing someone would cost billions. A settlement would, as the astrophysicist and ethicist Nesvold noted, wonder, Is it even worth it? Theyd be far more liable to consider styles of justice that dont involve locking people up. The same goes for environmental thinking. Water and air will be so precious to space settlers that the people who are living in space are going to be much more concerned about resource conservation, Schwartz said. It could be the attitudes that we get there are ones that are helpful to send back [to Earth].

The idea of space as a fresh slate for political thinking is enticing. But its hemmed in by the very nature of the market forces currently reaching for the skies. Would any private-sector firms heading to space agree to limit their power when theyre beyond Earths grasp? Nesvold and Lucianne Walkowicz think its possible. There is, they believe, a window of opportunity right now, while commercial space activity is still ramping up, to convince everyone in New Spacefrom the firms to their early (and crucial) governmental clientsto take space ethics seriously. Theyve been pursuing two tracks of inquiry along these lines: first, talking directly to New Space companies about the political, social, and environmental aspects of space exploitation. (The smaller firms, Nesvold noted, are often eager to talk; the big onesthe SpaceXs and Blue Originsnot so much.) Walkowicz has also been holding public events to get everyday citizens to discuss, as she put it, becoming interplanetary.

I think making the infrastructure of getting to spaceflight cheaper and more sustainable, reusable, all of that stuff is greatI love watching rocket launches as much as the next person, Walkowicz told me. But she wants a much broader cross-section of the public to have a voice on how space is used. As she frames things, its a simple matter of public accountability: For all the self-mythologizing among New Space titans about the new, scrappy, and libertarian cast of modern space exploration, its still NASAand by extension, the peoples treasurythats projected to supply the biggest revenue stream for much New Space activity today, and in the near future. In other words, we the people are paying for many of these rocket launches, and the huge outlays that will help bankroll the hard stuff, like future human colonies on the moon.

So the public ought to have more input on how the projected settlement and exploitation of outer space actually happens. Walkowicz and Nesvold want to create a bigger sample of people informed about the stakes in the new space race, people whod lobby Congress to help lay down the new American road rules for spacefrom keeping orbits clean to the question of who gets to ride on those taxpayer-funded rockets in the first place.

Space, in other words, needs to be decolonized. Thats a coinage gaining currency among some space thinkers, including Lindy Elkins-Tanton. Shes a planetary scientist with one foot in the world of New Space, and another in the world of space ethics. Shes the head of the NASA Psyche project, which is launching a probe next year to explore the metallic asteroid Psyche. On the one hand, she is herself benefiting directly from the lower costs that New Space has created, so shes generally a fan of commercial interests making space more viable. Her probe will launch on a SpaceX rocket, and its so much cheaper than NASAs older launches that it makes her science far more affordable. (Im sure Im not supposed to tell you, but Ill tell you: Its a lot of money, she said.)

Yet as Elkins-Tanton noted, the story of new frontiers being settled is the history of colonization, fueled by moneyed interests. Whether it was Europeans heading to North America or Africa or parts of Asia, it was generally huge state interests putting up the money for risk-taking explorerswith the explorers getting rich, the states amassing power, the new frontiers becoming gradually stripped of resources, and their indigenous populations either killed or impoverished.

Decolonization, as she and other New Space ethicists put it, would be a different route. Itd be the act of exploring space with that history in mind, and working deliberately in concert to avoid its brutalities. What would that mean? Elkins-Tanton argued, like Walkowicz and Nesvold, that any voyages to space need to have much greater democratic participation. For years, shes been organizing annual projects that bring together a disparate array of thinkersastrophysicists, artists, indigenous scholarsto plan for things such as how a Mars colony might exist without becoming a human rights nightmare.

We need artists and philosophers and sociologists, psychologists and every other kind of person thinking about how we do this thing, she said. This can sound, she admitted, touchy-feely. But in her own work as an astronomer, the big-tent approach has paid off. When Elkins-Tanton initially pitched the Psyche mission to NASA, she was competing with 28 other pitches, and asking NASA to commit $750 million. To build her proposal, she insisted her team members, down to the college interns, speak up about their concernshow things could go wrong, and what unexpected outcomes of the project might be. Our motto is, the best news is bad news brought early, she said. You need everybody to be able to speak up. In her pitch to NASA, she touted her insistent culture of inclusion. When NASA heads approved her mission over the other ones, they cited it as a crucial reason why.

To them, it was a success metric, she said. So now I can stand up and say: Culture is not for the weak. Culture is literally worth $750 million. It would be heartening if NASA seriously embraced this model. Decolonizing the way we explore space would actually honor the incredible unknowns and unexpected dangers the sustained commercial settlement of the heavens will bring. As John F. Kennedy said when he first argued for putting people on the moon: The greater our knowledge increases, the greater our ignorance unfolds.

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The role of the microbiota in human genetic adaptation – Science

Posted: December 6, 2020 at 10:37 am

Getting to the guts of local evolution

The microbiota of mammals is a product of coevolution. However, humans exhibit a range of adaptive peculiarities that can be quite geographically specific. The human microbiota also displays a variety of community compositions and a range of overlapping and redundant metabolic characteristics that can alter host physiology. For example, lactase persistence is a genetic characteristic of European populations, but in populations lacking the lactase gene, milk sugar digestion is endowed by the microbiota instead. Suzuki and Ley review the evidence for the role that the microbiota plays in local adaptation to new and changing human circumstances.

Science, this issue p. eaaz6827

When human populations expanded across the globe, they adapted genetically to local environments in response to novel selection pressures. Drivers of selection include exposure to new diets, climates, or pathogens. Humans harbor microbiotas that also respond to changes in local conditions and changes in their hosts. As a result, microbiotas may alter the adaptive landscape of the host through modification of the environment. Examples include changes to a foods nutritional value, the hosts tolerance to cold or low amounts of oxygen, or susceptibility to invading pathogens. By buffering or altering drivers of selection, the microbiota may change host phenotypes without coevolution between host and microbiota. Functions of the microbiota that are beneficial to the host may arise randomly or be acquired from the environment. These beneficial functions can be selected without the host exerting genetic control over them. Hosts may evolve the means to maintain beneficial microbes or to pass them to offspring, which will affect the heritability and transmission modes of these microbes. Examples in humans include the digestion of lactose via lactase activity (encoded by the LCT gene region) in adults and the digestion of starch by salivary amylase (encoded by the AMY1 gene)both are adaptations resulting from shifts in diet. The allelic variation of these genes also predicts compositional and functional variation of the gut microbiota. Such feedback between host alleles and microbiota function has the potential to influence variation in the same adaptive trait in the host. How the microbiota modifies host genetic adaptation remains to be fully explored.

In this paper, we review examples of human adaptations to new environments that indicate an interplay between host genes and the microbiota, and we examine in detail the LCTBifidobacterium and the AMY1Ruminococcus interactions. In these examples, the adaptive host allele and adaptive microbial functions are linked. We propose host mechanisms that can replace or recruit beneficial microbiota functions during local adaptation. Finally, we search for additional examples where microbiotas are implicated in human genetic adaptations, in which the genetic basis of adaptation is well described. These range from dietary adaptations, where host and microbial enzymes can metabolize the same dietary components (e.g., fatty acid and alcohol metabolism), through climate-related adaptations, where host and microbes can induce the same physiological pathway (e.g., cold-induced thermogenesis, skin pigmentation, and blood pressure regulation), to adaptations where hosts and microbes defend against the same local pathogens (e.g., resistance to malaria, cholera, and others). These examples suggest that microbiota has the potential to affect host evolution by modifying the adaptive landscape without requiring coevolution.

Well-studied examples of local adaptation across diverse host species can be revisited to elucidate previously unappreciated roles for the microbiota in host-adaptive evolution. In the context of human adaptation, knowledge of microbial functions and host genemicrobe associations is heavily biased toward observations made in Western populations, as these have been the most intensively studied to date. Testing many of the interactions proposed in this Review between host genes under selection and the microbiota will require a wider geographic scope of populations in their local contexts. Because genes under strong selection in humans are often involved in metabolic and other disorders and can vary between populations, future investigations of host genemicrobe interactions that relate to human adaptation may contribute to a deeper understanding of microbiota-related diseases in specific populations. Investigating host genemicrobe interactions in a wider variety of human populations will also help researchers go beyond collections of anecdotes to form the basis of a theory that takes microbial contributions to host adaptation into account in a formal framework. A better understanding of reciprocal interactions between the host genome and microbiota in the context of adaptive evolution will add another dimension to our understanding of human evolution as we moved with our microbes through time and space.

When human populations adapt genetically to new environments, their microbiotas may also participate in the process. Microbes can evolve faster than their host, which allows them to respond quickly to environmental change. They also filter the hosts environment, thereby altering selective pressures on the host. Illustrated here are examples of interactions between adaptive host alleles and adaptive microbiota functions where the microbiota likely modified the adaptive landscape in response to changes in diet (e.g., changes in levels of starch and milk consumption), exposure to local pathogens (e.g., malaria parasites and Plasmodium spp.), and changes in local climate (e.g., cold stress and hypoxia). In this paper, we discuss the resulting relationships between host-adaptive alleles and microbiota functions.

As human populations spread across the world, they adapted genetically to local conditions. So too did the resident microorganism communities that everyone carries with them. However, the collective influence of the diverse and dynamic community of resident microbes on host evolution is poorly understood. The taxonomic composition of the microbiota varies among individuals and displays a range of sometimes redundant functions that modify the physicochemical environment of the host and may alter selection pressures. Here we review known human traits and genes for which the microbiota may have contributed or responded to changes in host diet, climate, or pathogen exposure. Integrating hostmicrobiota interactions in human adaptation could offer new approaches to improve our understanding of human health and evolution.

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The role of the microbiota in human genetic adaptation - Science

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Is anyone on Earth not an immigrant? – Livescience.com

Posted: at 10:37 am

Human beings tend to be fascinated with their beginnings. Origin stories are found across cultures, religions, ethnicities and nationalities and they are all deeply important. These stories tell people where they come from, how they fit in and how everyone fits together.

One of these stories, of course, is the story of human genes, and it's a story anyone with human DNA shares.

As scientists find more ancient human DNA, sample more modern DNA and develop more ways to analyze this genetic material, it's revealing a lot about how early humans moved and moved and moved around the world, coming to inhabit nearly every swath of land.

So after thousands and thousands of years of nearly constant migration, are there any people out there who have never left the spot where it's thought Homo sapiens evolved? Put another way, is there anybody on Earth who isn't an immigrant?

Related: Why haven't all primates evolved into humans?

"From a scientific point of view, maybe the only people that you could consider not to be immigrants would be some Khoe-San-speaking groups in southern Africa," said Austin Reynolds, an assistant professor of anthropology at Baylor University in Texas who specializes in human population genetics.

The designation Khoe-San (pronounced coy-sawn) refers to certain African communities in the areas of Botswana, Namibia, Angola and South Africa who speak similar languages with distinctive clicking consonants, Reynolds told Live Science.

Reynolds said there are two main factors indicating that Khoe-San groups may be non-migratory descendants of original humans: They live in the place where it's likely humans first appeared, and they have a high amount of genetic diversity. A good way to understand why high genetic diversity indicates original ancestry is by comparing genes to a bowl of M&Ms, Reynolds said. Handfuls taken out of the bowl i.e. people who broke off from the original human population might have only a couple M&Ms colors in them, but the original bowl will have all the colors.

Yet despite the Khoe-San groups' proximity to the proverbial "cradle of humankind" and their significant genetic diversity, identifying them as the last genetically aboriginal peoples is not cut and dry.

Firstly, researchers dont know for sure that southern Africa is the cradle of humankind. Some scientists think humans first evolved in East Africa, said Reynolds, and scientists haven't amassed enough archaeological evidence in either area to be completely certain just where Homo sapiens first came on the scene.

There's even a possibility people evolved in western Africa, Mark Stoneking, a molecular geneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, told Live Science. Different environments do a worse or better job at preserving fossil remains, Stoneking said, so just because human remains were or were not found in specific places doesn't mean humans didn't live there long ago.

Stoneking doesn't think there are any folks left on Earth who aren't scientifically, at least immigrants.

"People have always been on the move," Stoneking said. His recent genetic research on populations across Asia has shown that there's a touch of just about everyone in everyone else. "All human populations have been in contact with others," including the Khoe-San, he said, denoted by evidence in their genes, their cultures and their languages.

Early humans moved extensively around Africa for more than 100,000 years before leaving, at which point they probably moved out of eastern Africa into the Middle East, Stoneking said. It's likely that not long afterward, people headed southeastward along the Indian coast, with many more waves of migrants following these original adventurers over a span of tens of thousands of years. Along the way, there would have been a great exchange of DNA, Stoneking said, and these two components movement and intermixture is what he sees as a defining characteristic of the human species.

"Humans what they like to do is migrate, and they like to have sex," Stoneking said. And so it seems to have been since time immemorial.

Originally published on Live Science.

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Insights on Human Genetics Market 2020 to 2027: COVID-19 Impact Analysis, Drivers, Opportunity Analysis, Restraints, and Forecast – The Courier

Posted: at 10:37 am

A new report added by Research Dive offers insights and puts forth the impact of COVID-19 catastrophe on the global human genetics market. According to the report, the human genetics market is estimated to grow at a significant rate and generate robust revenue share by 2027 during the forecast period from 2020 to 2027.

The report provides brief summary and an in-depth information of the market by collecting data from industry experts and different sources prevalent in the market. The statistics presented in the report are extensive, reliable, and the outcome of an exhaustive analytical research. The report offers qualitative and quantitative trend analysis for the period of 2020-2027 to assist stakeholders to understand the overall market scenario. Comprehensive analysis of the key segments validates the types of products used in the industry and their applications.

MARKET SEGMENTATION

On the basis of type, the global human genetics market is segmented into:

Product Type Segmentation Prenatal Genetics Cytogenetics Molecular Genetics & Symptom Genetics

For More Detail Insights, Download Sample Copy of the Report at: https://www.researchdive.com/request-toc-and-sample/2137

On the basis of application, the global human genetics market is segmented into:

Cytogenetics Molecular Genetics Prenatal Genetics Symptom Genetics Research Center Industry Segmentation Forensic Laboratories Hospital

On the basis of region, the global human genetics market is segmented into:

North America U.S. Canada Mexico

Europe Germany UK France Spain Italy Rest of Europe

Asia-Pacific Japan China India Australia South Korea Rest of Asia-Pacific

LAMEA Brazil Argentina Saudi Arabia South Africa UAE Rest of LAMEA

Connect with Our Analyst to Contextualize Our Insights for Your Business: https://www.researchdive.com/connect-to-analyst/2137

KEY COMPANIES COVERED

The research report summarizes and outlines several aspects of the key players operating in the global human genetics market such as company snapshot, business performance, product portfolio, recent developments & strategies, SWOT analysis, and many more. The key players listed are:

LGC Forensics Agilent Technologies QIAGEN N.V. Bode Technology Illumina Thermo Fisher Scientific Inc. Promega Corporation Orchid Cellmark Inc. NextOmics GE Healthcare Takara Bio Inc. Oxford Nanopore Pacific Biosciences

RECENT DEVELOPMENTS

The key players of the market are adopting several strategies to obtain a leading position in the global industry. For instance, in August 2020, Ancestry launched AncestryHealth, a product that features next-generation sequencing with an ability to screen the genes associated with blood disorders, breast cancer, colon cancer, and heart disease.

Contact Us:

Mr. Abhishek PaliwalResearch Dive30 Wall St. 8th Floor, New YorkNY 10005 (P)+ 91 (788) 802-9103 (India)+1 (917) 444-1262 (US) TollFree : +1 -888-961-4454Email:support@researchdive.comLinkedIn:https://www.linkedin.com/company/research-diveTwitter:https://twitter.com/ResearchDiveFacebook:https://www.facebook.com/Research-DiveBlog:https://www.researchdive.com/blogFollow us on:https://covid-19-market-insights.blogspot.com

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Insights on Human Genetics Market 2020 to 2027: COVID-19 Impact Analysis, Drivers, Opportunity Analysis, Restraints, and Forecast - The Courier

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Host genetics and infectious disease: new tools, insights and translational opportunities – DocWire News

Posted: at 10:37 am

This article was originally published here

Nat Rev Genet. 2020 Dec 4. doi: 10.1038/s41576-020-00297-6. Online ahead of print.

ABSTRACT

Understanding how human genetics influence infectious disease susceptibility offers the opportunity for new insights into pathogenesis, potential drug targets, risk stratification, response to therapy and vaccination. As new infectious diseases continue to emerge, together with growing levels of antimicrobial resistance and an increasing awareness of substantial differences between populations in genetic associations, the need for such work is expanding. In this Review, we illustrate how our understanding of the host-pathogen relationship is advancing through holistic approaches, describing current strategies to investigate the role of host genetic variation in established and emerging infections, including COVID-19, the need for wider application to diverse global populations mirroring the burden of disease, the impact of pathogen and vector genetic diversity and a broad array of immune and inflammation phenotypes that can be mapped as traits in health and disease. Insights from study of inborn errors of immunity and multi-omics profiling together with developments in analytical methods are further advancing our knowledge of this important area.

PMID:33277640 | DOI:10.1038/s41576-020-00297-6

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Host genetics and infectious disease: new tools, insights and translational opportunities - DocWire News

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Rare variants tied to neuronal migration, autism traits – Spectrum

Posted: at 10:37 am

Detailed look: Some mutations in the autism gene NCKAP1 interfere with a cells ability to transport NCKAP1 protein into and out of its nucleus.

Many people with mutations that disrupt a gene called NCKAP1 have autism or autism traits along with speech and language problems, motor delays and learning difficulties according to a new study. The results, from a large international team of researchers and clinicians, clarify how mutations in NCKAP1 affect people and solidify its position as a top autism gene.

Sequencing studies over the past decade have turned up three autistic people with de novo, or non-inherited, variants that likely disrupt NCKAP1, putting it on a list of genes strongly tied to autism. Other work has shown that mice that do not express the gene have atypical brain development.

But those reports contain little information about the outward characteristics of people with NCKAP1 mutations which are challenging to study because variants in the gene are rare, says Hui Guo, associate professor of life sciences at Central South University in Changsha, China.

In the new work, Guo teamed up with scientists and clinicians across the globe to identify and characterize 18 additional people with NCKAP1 mutations.

This study demonstrates that international cooperation among many institutions is becoming fundamental to advancing our understanding of rare variants, says Abha Gupta, assistant professor of pediatrics at Yale University, who was not involved in the study.

Painting a detailed picture of traits associated with NCKAP1 mutations can also improve a persons chance of being diagnosed and provide guidance about expected outcomes, she says.

Guo asked colleagues who collect genetic data for other research to sift through their records for people with NCKAP1 variants. He also used GeneMatcher, a site that connects researchers to clinicians interested in the same genetic variants.

For each person Guo and his colleagues identified, they followed up to assess that individuals clinical traits; they either contacted the person directly or asked medical professionals to review the persons records.

The researchers also collected genetic and clinical information about family members of the people with NCKAP1 mutations to determine if the variants had been inherited.

In all, the team identified and characterized the traits of 21 affected people across seven countries.

Thats a lot of work, considering how rare an NCKAP1 variant is, says Megan Dennis, assistant professor of biochemistry and molecular medicine at the University of California, Davis MIND Institute, who was not involved in the study.

The people in Guos cohort ranged in age from 7 to 23 years at the time they were assessed.

The researchers diagnosed autism in 10 out of 15 participants who had been previously assessed for the condition; 2 others have autism traits but no formal diagnosis; the remaining 3 have no reported autism traits. Another 12 participants have difficulties with speech and language, 11 have delayed motor function, and 11 have intellectual or learning disabilities.

According to the clinical assessments, nine of the participants have had sleep problems and seven have experienced seizures, both of which are also associated with autism. The results were published in The American Journal of Human Genetics in November.

Guo and his colleagues further investigated the variants effects on NCKAP1 function by introducing mutations from five participants into cultured human embryonic kidney cells. They tagged NCKAP1 protein with a fluorescent marker to trace its location in the cells.

NCKAP1 protein is typically present throughout the cell. Two variants, though, cause it to appear mainly in the cytoplasm, suggesting that these mutations create problems with transporting the protein into and out of the nucleus.

The team also evaluated how NCKAP1 expression varies throughout development by using the BrainSpan atlas, which catalogs gene-expression data from human brain tissue from 8 weeks after conception to 40 years of age. NCKAP1 is highly expressed during the second and third month of prenatal development, and at multiple points throughout a persons life, they found.

They also found that the spatial distribution of NCKAP1 expression across the brain most closely resembles the spatial distribution of gene clusters associated with excitatory neurons and radial glia, and not with inhibitory neurons. This pattern suggests the NCKAP1 gene has a function that is specific for these cell types perhaps by regulating their structure or ensuring that they differentiate properly, the researchers say.

The team further compared the brains of typically developing mice with those of mice that were treated to express less NCKAP1 protein. They injected the embryonic mice with a fluorescent protein that tags nascent cortical neurons, and then assessed where those cells ended up after two or four days. In mice that express less NCKAP1, many of the neurons did not arrive at the correct final location, the team found, suggesting that the gene may play a role in the migration of these cells. That finding, though preliminary, fits with prior work tying premature NCKAP1 expression to delayed neuronal migration.

The functional studies shed some light on the mechanisms that may underlie a genetically based form of autism, Dennis says. But in terms of being able to have any kind of actionable clinical information, theres still more to be done.

Guo and his colleagues plan to characterize the traits tied to rare mutations in other top autism genes, with the goal of defining specific genetic or molecular subtypes of the condition.

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Rare variants tied to neuronal migration, autism traits - Spectrum

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Seminars Explore the Immorality of the Eugenics Movement and Its Implications Today – Bowdoin News

Posted: at 10:37 am

Hadley Horch and Scott McEachern

The second session featured Horch alongside noted anthropologist and former Bowdoin professor Scott MacEachern, who is now vice chancellor for academic affairs at Duke Kunshan University in China. This discussion, titled Eugenics and the IQ Test, revisited the theme of the misuse of scientific knowledge. Particular attention was paid to the problems of trying to define and measure intelligence. Any documented difference in IQ scores between different racial and ethnic groups says more about inequality in societies than it does about intelligence, said Horch. Environmental and cultural factors are rarely well-controlled in these comparison studies, she added.

There are important lessons to be learned from studying the impact of eugenics in the last century, said Horch and Logan. Today we are exposed to brand new sources of information, vast troves of genomic information that weve never had before, said Logan, and in managing that there comes huge ethical responsibility. He is referring to the era ushered in by the Human Genome Projecta multiyear international scientific effort to map all human genes. The thirteen-year project, which concluded in 2003, has given scientists the most accurate reading yet of the entire human genetic sequence and greatly increased our capacity to survey the genomes of humans and other organisms. The discovery, said Logan, marked a quantum leap in human knowledge. There are, however, problems with the huge data sets used in the project, said Horch, because about 70 percent of the genetic information sampled is from people of white European stock. This points to an inherent bias in the data, she explained, so there is much in the way of complexity and richness that is not represented.

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