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Category Archives: Transhuman News

Types of Psoriasis: Pictures, Symptoms and Treatments – Healthline

Posted: December 18, 2022 at 2:30 pm

Psoriasis is a chronic skin disease. Its considered an immune-mediated disease. This means the immune system acts abnormally.

Psoriasis typically affects the skin, causing skin cells to build up faster than usual. It can also affect other organ systems, especially the joints.

According to a 2021 study, about 7.5 million U.S. adults 20 years or older have psoriasis a 3 percent prevalence rate (occurrence of a condition). By race and ethnicity, the prevalence rates are:

Psoriasis causes your skin to develop scaly patches that can be itchy and painful.

Psoriasis tends to be pink or red on people with light or fair skin tones, with silvery-white scale. On medium skin tones, it can appear salmon-colored with silvery-white scale. On darker skin tones, the psoriasis could look violet, brown, or reddish brown often with light-colored or grayish-colored plaques.

There are different types of psoriasis, and its possible to have more than one type.

Theres limited research and information about managing and diagnosing psoriasis in People of Color. A 2014 study found the prevalence of psoriasis among adults ages 20 and older to be 3.2 percent, and found the rates vary by race and ethnicity:

These numbers may not tell the entire story, as People of Color may be disproportionately undertreated and misdiagnosed. This is because psoriasis isnt always recognized on darker skin tones as it is for people with lighter skin tones.

Read on to learn more about these different types and how theyre treated.

The most common symptoms of psoriasis include:

The symptoms of psoriasis also vary based on the type. There are eight types of psoriasis:

Psoriasis can lead to mental stress, anxiety, and low self-esteem. Depression is also common in people who have psoriasis.

Other diseases, such as Crohns disease, celiac disease, metabolic syndrome, and cardiovascular disease, have been linked with psoriasis.

There are also subcategories of psoriasis types. These appear differently depending on the location of the body. Psoriasis isnt contagious regardless of type.

Psoriasis patches on darker skin tones may also be more widespread, which can make it difficult to diagnose.

Generally, psoriasis patches appear more purple or brown on darker skin tones, often with thick silvery plaques.

Plaque psoriasis, or psoriasis vulgaris, is the most common form of psoriasis. An estimated 80% to 90% of people with psoriasis have plaque psoriasis. Its characterized by thick red or purplish patches of skin, often with a silvery-white or gray scales.

These patches often appear your elbows, knees, lower back, or scalp.

Patches are usually 1 to 10 centimeters wide, but can also be larger and cover more of your body. If you scratch at the scales, the symptoms will often get worse.

As a way to ease discomfort, a doctor may recommend applying moisturizers to keep the skin from becoming too dry or irritated. These moisturizers include an over-the-counter (OTC) cortisone cream or an ointment-based moisturizer.

A doctor may also work to identify your unique psoriasis triggers, including stress or lack of sleep.

Other treatments may include:

Medication may differ for guttate or erythrodermic psoriasis.

In some cases, you may need light therapy. This involves exposing the skin to both ultraviolet (UV)A and UVB rays. Sometimes, treatments combine prescription oral medications, light therapies, and prescription ointments to reduce inflammation.

With moderate to severe cases, you may be prescribed systemic medication in the form of oral, injectable, or intravenous (IV) medication.

Guttate psoriasis appears in small red spots on the skin. In darker skin tones, these spots can appear violet or brown. Its the second most common type, affecting around 8% of people with psoriasis. Most of the time, it starts during childhood or young adulthood.

The spots are small, separate, and drop-shaped. They often appear on the torso and limbs, but they can also appear on your face and scalp. Spots are usually not as thick as plaque psoriasis, but they can develop into plaque psoriasis over time.

Guttate psoriasis happens after certain triggers. These triggers include:

To treat guttate psoriasis, a doctor may prescribe steroid creams, light therapy, and oral medications. Determining the underlying cause of the infection can also help clear guttate psoriasis. If a bacterial infection caused the condition, antibiotics may help.

Flexural or inverse psoriasis often appears in skinfolds, such as under the breasts or in the armpits or groin area. This type of psoriasis is red or purple and often shiny and smooth.

The sweat and moisture from skinfolds keeps this form of psoriasis from shedding skin scales. Sometimes, its misdiagnosed as a fungal or bacterial infection. The skin-on-skin contact can make inverse psoriasis very uncomfortable.

Most people with inverse psoriasis also have a different form of psoriasis in other places on the body.

The treatments for inverse psoriasis are like plaque psoriasis treatments. They can include:

A doctor may prescribe a lower potency steroid cream to avoid your skin from thinning too much. You may also benefit from taking or applying medications that reduce yeast or bacteria growth.

Pustular psoriasis can be severe at times. This form of psoriasis may develop quickly in the form of many white pustules surrounded by red or darkened skin.

Pustular psoriasis may affect isolated areas of your body, like your hands and feet, or cover most of the skins surface. These pustules can also join together and form scaling. However, if it affects all areas of the body such as the Von Zumbusch subtype it can be life threatening because it has severe systemic effects.

Some people experience cyclic periods of pustules and remission. While the pus is noninfectious, this condition can cause flu-like symptoms such as:

There are three kinds of pustular psoriasis:

Each of the three forms of pustular psoriasis can have different symptoms and severity.

Treatment may include OTC or prescription corticosteroid creams, oral medications, or light therapy. Biologics may also be recommended.

Identifying and treating the underlying cause may also help reduce reoccurrence of pustular psoriasis.

Erythrodermic psoriasis, or exfoliative psoriasis, is a rare type of psoriasis that looks bright red or dark purplish in people with darker skin tones along with shedding of the skin. The condition is serious and is a medical emergency. You may need to be hospitalized, as your body may not be able to manage your body temperature.

This form of psoriasis is widespread, with red or purple skin and silvery scales. It may cover large portions of your body. Exfoliation often occurs in larger pieces than the small scales typical to most psoriasis.

Erythrodermic psoriasis can develop from:

This condition often needs attention at a hospital. There, youll receive a combination of therapies.

This can include an application of medicated wet dressings, topical steroid applications, biologics, or prescription oral medications until symptoms have improved.

Make an appointment with a doctor if you think you have erythrodermic psoriasis.

Psoriatic arthritis (PsA) is a painful and physically limiting condition that affects between 30% and 33% of people with psoriasis. There are five types of PsA with varying symptoms. Theres also no cure for this condition.

Psoriasis is an autoimmune disease, so it can trigger your body to attack your joints and skin. It can affect many joints and often becomes quite severe in the hands and affect the nails. Skin symptoms usually appear before joint symptoms.

Treatments for psoriatic arthritis can include nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) and naproxen sodium (Aleve). NSAIDs can help reduce the incidences of swelling and pain associated with psoriatic arthritis.

Prescription medications, such as an oral corticosteroid, may also help reduce inflammation that leads to psoriatic arthritis. Prescription topical medications used to treat psoriatic arthritis include salicylic acid, calciopotriene, and tazarotene.

A unique category of medications known as disease-modifying antirheumatic drugs (DMARDs) can help reduce inflammation and joint damage. Biologics, which are a subcategory of DMARDs, may be prescribed to reduce inflammation at a cellular level.

Although not an official type of psoriasis, nail psoriasis is a manifestation of psoriasis. The condition can often be confused with fungal infections and other infections of the nail.

Nail psoriasis can cause:

Sometimes, the nail can even crumble and fall off. Theres no cure for psoriatic nails, but some treatments may improve the health and appearance of nails.

Treatments for nail psoriasis are like the ones used for plaque psoriasis. It may take time to see the effects of these treatments as nails grow very slowly. Treatment options include:

Scalp psoriasis is common in people with plaque psoriasis. For some people, it may cause severe dandruff. For others, it can be painful, itchy, and very noticeable at the hairline. Scalp psoriasis can extend to your neck, face, and ears in one large patch or many smaller patches.

In some cases, scalp psoriasis can complicate regular hair hygiene. Excessive scratching can cause hair loss and scalp infections. The condition may also cause feelings of social stress.

Topical treatments are most commonly used for scalp psoriasis. They may require an initial 2 months of intensive applications, plus permanent, regular maintenance. Treatment options include:

Light therapy, oral medications, and biologics also may be recommended depending on the responsiveness to treatment.

Theres no one cure for any form of psoriasis, but remission and significant healing is possible. Your doctor will work with you to create a treatment plan that helps manage your condition. You can also take steps at home to manage psoriasis.

These can include:

Doctors may slowly build up to the most effective treatment plan for your psoriasis symptoms. Most start with a topical or light therapy treatment and only progress to systemic medications if the first line of treatment is unsuccessful.

Stress, anxiety, depression, and other mental health conditions can be commonly found in people with psoriasis. You may benefit from therapy or support groups where you can meet other people experiencing similar issues or concerns.

You can also talk with a healthcare professional about seeing a therapist who has experience with psoriasis. Theyll be able to help identify ways to cope.

Visit the National Psoriasis Foundation for the latest information on research, events, and programs.

There are different types of psoriasis that present different symptoms. While theres no cure for psoriasis, treatment can help relieve and manage your symptoms. Talk with a doctor if youre concerned about your skin.

The type of psoriasis you have, and its severity, will determine your treatment. Generally speaking, milder cases with smaller psoriasis patches can often be treated topically. More serious cases, with larger patches, may require systemic treatment.

Many people believe that psoriasis is contagious, but it wont spread from person to person. Researchers believe that a combination of genetics and environmental and immune system factors cause psoriasis.

Thanks to the advocacy work of dozens of psoriasis activists and organizations, psoriasis is also gaining more support and awareness. Talk with a doctor if you believe you have psoriasis. Theyll be able to provide treatment options and coping methods.

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Types of Psoriasis: Pictures, Symptoms and Treatments - Healthline

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Regenerative Medicine Advanced Therapy Designation | FDA

Posted: at 2:29 pm

As described in Section 3033 of the 21st Century Cures Act, a drug is eligible for regenerative medicine advanced therapy (RMAT) designation if:

Based on FDAs interpretation of Section 506(g) of the Federal Food, Drug, and Cosmetic Act (as added by Section 3033 of the 21st Century Cures Act), certain human gene therapies and xenogeneic cell products may also meet the definition of a regenerative medicine therapy. For more information on FDAs definition of regenerative medicine therapies, refer to the Guidance for Industry, Expedited Programs for Regenerative Medicine Therapies for Serious Conditions.

The request for RMAT designation must be made either concurrently with submission of an Investigational New Drug application (IND) or as an amendment to an existing IND. We will not grant a RMAT designation if an IND is on hold or is placed on hold during the designation review.

You may submit a request for RMAT designation to:

Food and Drug AdministrationCenter for Biologics Evaluation and ResearchOffice of Tissues and Advanced TherapiesDocument Control Center10903 New Hampshire AvenueWO71, G112Silver Spring, MD 20993-0002

If the RMAT designation request is submitted to your IND as an amendment, the cover letter should specify that the submission contains a REQUEST FOR REGENERATIVE MEDICINE ADVANCED THERAPY DESIGNATION in bold, uppercase letters. If the request is submitted with an initial IND, the cover letter should specify that the submission contains both an INITIAL INVESTIGATIONAL NEW DRUG SUBMISSION and REQUEST FOR REGENERATIVE MEDICINE ADVANCED THERAPY DESIGNATION in bold, upper case letters.

No later than 60 calendar days after receipt of the designation request, the Office of Tissues and Advanced Therapies (OTAT) will notify the sponsor as to whether RMAT designation has been granted. If OTAT determines that the RMAT designation request was incomplete or that the drug development program does not meet the criteria for RMAT designation, OTAT will include a written description of the rationale for such determination.

10/06/2021

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Regenerative Medicine Advanced Therapy Designation | FDA

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‘Yellowstone’ Season 5, Episode 6 Recap: Jamie and Sarah Join Forces, Plan to Oust John as Governor – Entertainment Tonight

Posted: December 16, 2022 at 6:35 pm

'Yellowstone' Season 5, Episode 6 Recap: Jamie and Sarah Join Forces, Plan to Oust John as Governor  Entertainment Tonight

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'Yellowstone' Season 5, Episode 6 Recap: Jamie and Sarah Join Forces, Plan to Oust John as Governor - Entertainment Tonight

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Story Time From Space

Posted: December 14, 2022 at 9:33 am

New Reading!

Una dreams of a life in Space. Life on Earth is just so so-so. But how will she get there? And will she complete her mission to discover life in Space? And did she remember to feed Neil the goldfish?

On May 19th 2021,Give Me Some Space!was read to over 1.98 million children across Australia and New Zealand simultaneouslyby NASA astronautShannon Walker from theInternational Space Station!

National Simultaneous Storytime is held annually, thanks to the Australian Library and Information Association (ALIA). Each year, one book is selected to be read simultaneously in libraries, schools, pre-schools, childcare centers, family homes, bookshops and many other places around Australia and New Zealand.

Be sure to watch the Science Time From Space companion video: Sun, Earth, and Space

Maybe you remember when a little robotic spacecraft landed on a far-off planet. On August 6, 2012, the roverCuriositytouched down on the rocky surface of Mars and now shes ready to guide you through her journey firsthand. From idea to creation and beyond, this fact-filled, stylish book introduces readers toCuriosityand her mission: to discover more about the red planet and search for evidence of life. How didCuriosityget her name? What tools does she use to carry out her tasks? In her own voice, the popular NASA rover tells how and why she traveled more than 350,000,000 miles to explore a planet no human has ever visited . . . and what shes been doing there. In his debut picture book, Markus Motum bringsCuriositys story to life in vivid color: the deep blues of space set off the warm, rusted hues of Marss dusty red surface, marking this lovable rover and her mission as something special truly a world apart.

Re-watch our very first LIVE Story Time From Space reading from the International Space Station! Read along with astronaut Shannon Walker as we follow the extreme adventures of Willow the Water Bear.

Link:
Story Time From Space

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Boom! Watch an inflatable space station module explode on video – Space.com

Posted: at 9:33 am

  1. Boom! Watch an inflatable space station module explode on video  Space.com
  2. Experimental Inflatable Space Station Segment Explodes Violently  Futurism
  3. Sierra Space Successfully Completes Series of Major Development Milestones for First Commercial Space Station  Business Wire
  4. Inflatable Space Station Prototype Explodes During Testing; Heres What Happened  Gizbot
  5. Major development milestones completed by Sierra Space for their 1st commercial spacestation SatNews  SatNews
  6. View Full Coverage on Google News

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Boom! Watch an inflatable space station module explode on video - Space.com

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Heads or tails: What statistical models tell us about the probability of living beyond 110 – The Conversation

Posted: December 12, 2022 at 4:44 am

Heads or tails: What statistical models tell us about the probability of living beyond 110  The Conversation

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Heads or tails: What statistical models tell us about the probability of living beyond 110 - The Conversation

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LinkedIn founder and VC Reid Hoffman says human amplification via A.I. will revolutionize large enterprises in the next five years – Fortune

Posted: at 4:44 am

LinkedIn founder and VC Reid Hoffman says human amplification via A.I. will revolutionize large enterprises in the next five years  Fortune

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LinkedIn founder and VC Reid Hoffman says human amplification via A.I. will revolutionize large enterprises in the next five years - Fortune

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Maj Toure: Why Black Gunsand LibertarianismMatter

Posted: at 4:40 am

Today's episode is guest-hosted by my Reason TV colleague Zach Weissmueller. Zach went to Philadelphia to talk with Maj Toure, who runs the Solutionary Center in North Philadelphia. It's a place for locals to learn firearms skills and safety, how to avoid and de-escalate conflicts, and to pick up other life skills ranging from first aid to yoga to phlebotomy. "We hear a lot of people say, 'If these communities would just pull themselves up by the bootstraps,'" says Maj. "Okay, this is the bootstraps."

The Philly native is a hardcore libertarian, founder of the gun rights group Black Guns Matter, and a supporter of the Mises Caucus that recently took control of the Libertarian Party. He tells Reason that libertarians can improve their outreach in urban America by getting behind leaders and organizers who have an intuitive understanding of the needs and concerns of the residents who live there.

Here is the Reason interview with Maj Toure.

Today's sponsors:

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Maj Toure: Why Black Gunsand LibertarianismMatter

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Georgia’s ‘blank ballot’ voters | Who are they? And why did they do it? – 11Alive.com WXIA

Posted: at 4:40 am

Georgia's 'blank ballot' voters | Who are they? And why did they do it?  11Alive.com WXIA

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Georgia's 'blank ballot' voters | Who are they? And why did they do it? - 11Alive.com WXIA

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Exclusive: No official records of personal meeting between Institute of Economic Affairs and Jacob Rees-Mogg – NationalWorld

Posted: at 4:40 am

Exclusive: No official records of personal meeting between Institute of Economic Affairs and Jacob Rees-Mogg  NationalWorld

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Exclusive: No official records of personal meeting between Institute of Economic Affairs and Jacob Rees-Mogg - NationalWorld

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