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Investigation Explores Relationship Between Psoriasis and Autoimmune Disorders – AJMC.com Managed Markets Network
Posted: January 9, 2021 at 2:34 pm
Patients with psoriasis may be more likely to have additional autoimmune disorders, including vitiligo, diabetes, autoimmune thyroiditis, rheumatoid arthritis, and inflammatory bowel disease.
Patients with psoriasis may be more likely to have additional autoimmune disorders, including vitiligo, diabetes, autoimmune thyroiditis, rheumatoid arthritis, and inflammatory bowel disease (IBD), according to study results published in Indian Dermatology Online Journal.
Although the exact etiology of psoriasis is unknown, genetic, metabolic, and immunologic mechanisms have all been implicated in the conditions pathophysiology. Between 0.5% and 11.4% of individuals around the world are affected by psoriasis.
Psoriasis, an immune-mediated inflammatory dermatosishas been widely viewed as an autoimmune disease in view of flare-ups in psoriasis being triggered by bacterial microbiota by molecular mimicry, the researchers explained. The efficacy of various targeted therapies, both in psoriasis and other autoimmune disorders, further upholds this view.
Because no autoantigens or self-reactive T cells that trigger psoriasis have been authenticated, the issue as to whether psoriasis ought to be considered a bona fide autoimmune disease remains. To better understand the profile of autoimmune disorders among Indian patients with psoriasis, the researchers recruited 80 consecutive patients with chronic plaque psoriasis from an outpatient clinic between 2017 and 2018.
Any patient taking systemic retinoids, corticosteroids, or other immunomodulator drugs in the last 3 months were excluded from the study. In addition, psoriasis severity was graded based on Psoriasis Area and Severity Index (PASI) scores (mild PASI < 6; moderate PASI = 6-12; and severe PASI > 12).
Biological data were gleaned from blood samples, measurements of antithyroid peroxidase (anti-TPO) antibodiesand glycated hemoglobin, and other assessments. The majority of patients included were male (n = 57). The mean (SD) patient age was 42.04 (13.47) years, with a mean disease duration of 58.8 (60.6) months.
Analyses revealed:
Deranged thyroid status in 7 (8.8%) patients in this study was consistent with hyperthyroidism in 1 and hypothyroidism in 2 patients, the authors wrote, while the other 4 (5.0%) patients with euthyroid status had elevated anti-TPO antibodies indicating possible subclinical autoimmune thyroiditis.
Because of the relatively small number of patients included in the study, future long-term investigations may be able to better delineate the role of these hormones in the etiopathogenesis of psoriasis as an autoimmune disorder, the researchers explained.
The presence of clinical and laboratory abnormalities in patients with psoriasis reflects subtle autoimmunity or a predilection for isolated or multiple diseases within the psoriasis-associated autoimmunity spectrum, which may remain asymptomatic, the authors concluded. Screening for concurrent autoimmune disorders seems prudent for holistic management of patients with psoriasis.
Reference
Vashist S, Mahajan VK, Mehta KS, et al. Association of psoriasis with autoimmune disorders: results of a pilot study. Indian Dermatol Online J. Published online September 19, 2020. doi:10.4103/idoj.IDOJ_648_19
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Peeling feet: Causes, treatments, and remedies – Medical News Today
Posted: at 2:34 pm
Peeling feet have several potential causes. Foot injuries, dry skin, and athletes foot, among other conditions, can all cause peeling skin on the feet.
Peeling feet may look dry and scaly. The skin may peel all over or only in certain areas. Sometimes, peeling is the only symptom, but the feet may also itch or develop yellow patches.
Dry or peeling skin on the feet is not usually a symptom of a severe condition. However, if a person has other symptoms, develops foot wounds, or experiences intense foot pain, a doctor may need to examine peeling feet to rule out a health condition.
This article will examine the causes of peeling feet. It will also look at some potential treatments and when a person should contact a doctor.
There are several causes of peeling feet, including:
Corns and calluses both cause dead skin to build up. This can lead to hard, scratchy growths on the feet that sometimes crack open or peel. Peeling them down to the surface of the skin may cause bleeding or pain.
Calluses tend to appear on the bottom of the feet and feel hard. They are usually not painful but can be tender to touch. Corns cause dead skin to grow around inflamed skin, which may hurt. They look waxy and often appear on the toes.
Doctors sometimes call corns clavi or helomas.
Corns and calluses are not dangerous, but they can be uncomfortable. People should not attempt to cut them off or remove them, as this may cause painful injuries and infections.
Dry skin, especially in the winter months and in dry climates, may cause the feet to become so dry that they peel or crack open and bleed.
A person may also have other symptoms on their feet, such as:
Dry skin is not dangerous. However, if it is severe enough to cause the skin of the feet to crack open, there may be a higher risk of infection.
Eczema is a type of inflammatory skin condition that causes the body to overreact to harmless substances. This can lead to inflammation in healthy skin.
The skin may look or feel dry, but eczema is not just dry skin. It can also cause painful flushed or white patches and even blisters.
Atopic dermatitis, which is the most common form of eczema, occurs when the immune system damages the skins moisture barrier, causing it to become dry. This may cause peeling feet. A person may also have eczema patches on other parts of the body.
Dyshidrotic eczema primarily affects the hands and feet, and it can cause tiny flushed blisters on the toes. These blisters may be itchy and peel or break open. Some people mistake this type of eczema for other kinds of blisters, as they look similar.
Psoriasis is a chronic autoimmune condition that causes the body to attack healthy tissue. This causes skin cells to turn over much faster than usual. It can occur anywhere on the body but typically affects the elbows, knees, and bottoms of the feet.
People with psoriasis may notice flushed, thickened patches that look gray or silvery on their feet. The skin may peel, itch, or turn yellow over time.
Although dry skin does not cause psoriasis, moisturizing the skin may help psoriasis heal more quickly.
Athletes foot is a highly contagious fungal infection that may cause yellow or white patches on the feet, toes, or areas under the nails.
The feet may itch or look dry, and the skin may sometimes peel. A person may be more likely to experience athletes foot when their feet come into contact with contaminated surfaces, such as gym floors or showers.
Blisters usually appear when something rubs against the foot, causing small, fluid filled bumps to develop.
Blisters are typically harmless, but they can be painful. Wearing shoes that rub on the same areas of the feet may cause blisters to crack open and bleed.
People should not pop a blister, as it may become painful and bleed. Popping a blister may also increase the risk of infection.
Diabetes can damage blood vessels, which may affect blood flow to the feet. The reduction in blood flow increases the risk of various foot issues, including dry skin that cracks open and bleeds.
People with diabetes and foot pain or dry skin that does not go away should contact a doctor.
Peeling feet may be uncomfortable. There are several potential causes, and the best treatment or home care option will depend on the cause.
Dry skin may rub on shoes and crack open, causing intense pain and making walking difficult. Usually, a person can treat dry skin at home with moisturizers. If it becomes severe, however, they should consider seeking advice from a doctor.
A doctor may prescribe medications to manage chronic conditions, such as psoriasis, which may improve peeling feet.
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Weight Training with Psoriatic Arthritis: What to Know – Healthline
Posted: at 2:34 pm
If youve been diagnosed with psoriatic arthritis (PsA), you might not feel like exercising. The stiffness and fatigue of PsA along with pain and swelling might leave you choosing a more restful activity. But exercise can actually make it easier to manage your condition.
Exercises that are tailored to PsA can help alleviate symptoms. You should strive for a balance of cardiovascular fitness, range of motion exercise, stretching, and strength training. Strength training in particular can help build muscle to support and protect affected joints.
Each case of PsA is different. Before starting an exercise routine, have a physiotherapist assess your condition and make exercise recommendations best suited to your situation. Ask if weighted exercises are a strength-training option for you, and which types of movements can help rather than hinder your PsA management.
Once youve been cleared by a healthcare provider to try weight training, find a trainer to teach you proper form, execution, and breathing techniques to help you get the most out of your routine.
Weighted exercises use free weights, weight machines, or bodyweight to increase the force on your muscles to strengthen them.
These come in several styles, such as fixed and adjustable dumbbells, barbells, and kettlebells. There are also wearable wrist and ankle weights if PsA interferes with your grip.
Use weights for lifting, or for increasing your bodyweight for moves such as lunges.
Start with a light weight and work your way up over time as you build strength. If you find a movement difficult, like lateral raises, practice them without weights until your strength has improved.
Gym weight rooms have a wide selection of free weights. Once youve tried a few options, consider buying some of your own to enjoy the freedom of exercising at home.
Examples of free weight arm exercises include:
While theyre not as versatile as free weights, weight machines can be easier and safer when used correctly if youre new to strength training. Before you try a machine for the first time, ask a trainer to show you how to use it properly.
Weight machine exercises include:
This type of activity uses the weight of your body as resistance against gravity to help strengthen your muscles. They can be done in your home at your convenience. Use a yoga mat to cushion any area of your body thats in contact with the floor. Work with a trainer to learn how to use proper form to prevent injuries.
As you build strength over time, you can increase the intensity of bodyweight exercises by holding free weights while you work out. If finger pain is one of your PsA symptoms, try a weighted vest or wrist and ankle weights instead of free weights.
Bodyweight exercises to try include:
Ask a trainer to show you the correct way to perform any type of weighted exercise, both for safety and to help you achieve maximum health benefits. Proper body position is important to support your spine and joints and to protect them from injury. Find a trainer with knowledge about PsA who can help you follow the recommendations from your physiotherapist.
From there, be sure to set up your workout plan with three main factors in mind:
Intensity: If you have no prior weight training experience, you should begin with a very light intensity. This allows time for your muscles and joints to adjust to your new activity. Focus on learning proper form and injury prevention techniques. Once your muscle strength has increased, you can gradually increase the intensity of your strength training workout.
Frequency: The American College of Sports Medicine (ACSM) recommends performing strength training exercises 2 to 3 times each week. Allow rest days in between workouts.
Repetitions and sets: The weights you use should be comfortable to lift for 8 to 12 repetitions (reps) in a row with good form. If you cant do at least 8 reps, the weights youre using are too heavy. If youre able to continue lifting well beyond 12 reps, you can increase the weight.
One set is 8 to 12 reps. Aim for 2 to 3 sets per workout for each muscle group that youre focusing on.
Remember to warm up before you exercise. Start with slow and easy range of motion movements. During your workout, pay attention to how you feel and slow down or stop if necessary. Listen to your body and dont push yourself.
Weight lifting is typically a safe PsA activity, but speak with your doctor first. Each case is different, so its important to get clearance from your healthcare team before you try weightlifting.
When done correctly, even moderate weight training can help arthritis management. Benefits include:
Strong muscles can also absorb more of the shock from daily movements that is otherwise felt by your joints.
To keep weight lifting safe for PsA, its important to follow proper precautions. Do not try movements or exercises that your doctor has advised against.
Other potentially harmful practices include:
Any of these things can put too much stress on your joints, which can in turn aggravate PsA symptoms.
Exercise can help manage the symptoms of PsA by strengthening muscles that support joints. See a physiotherapist first for an assessment of your condition and exercise recommendations.
Types of weight training include free weights, exercise machines, and bodyweight exercise. Ask a trainer to show you the correct way to perform each exercise so you can achieve the most benefit and reduce your chance of injury.
Start with light intensity and focus on learning proper form. Gradually increase the intensity over time. Schedule rest days in between workout days.
Pay attention to how you feel while you practice weight training. Stop and rest if you experience discomfort or pain. During a PsA flare, reduce the intensity of your exercise routine, or take a break entirely.
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DiCE gets its ‘library’ card ready as it speeds development of DNA database-derived molecules with more investor cash – Endpoints News
Posted: at 2:34 pm
Investors like to see big plans, and Kevin Judice has plenty. The DiCE Molecules CEO is plotting a clinical trial launch for the biotechs lead small molecule for psoriasis and wants to double the staff in the next year and a half.
On Friday, those big plans landed him an $80 million Series C round.
Were very excited about it, he said of the raise led by RA Capital Management.
The round comes around two years after a $50 million Series B. While the B round was used for optimizing technology and building a pipeline, Judice says the Series C will propel the biotechs IL-17 antagonist to the clinic and fund the development of two other undisclosed programs.
This new capital allows us to expand our reach and get at more targets and have more opportunities to make high impact, Judice said.
DiCEs development process revolves around its DNA-encoded library. Such libraries allow researchers to screen millions even billions of compounds in parallel, using DNA tags that Judice compared to barcodes, which tell you what the constituent pieces of a molecule are.
Usually you do some kind of screen, like a high-throughput screen, or a DNA-encoded library screen, something like that, and you get a few hits. And then theres a long phase of just lab chemistry, where youre making individual compounds and trying to progress those hits, those initial binders, to something thats closer to a drug, Judice said.
That hit-to-lead phase is typically labor-intensive and slow, the CEO said. But DiCEs approach accelerates that work by using a smaller DNA-encoded library much smaller but richer in information, Judice said to screen in different ways after getting a hit.
What were actually looking for is the difference between just binding and something that is functional, Judice said.
DiCEs lead program is an agonist for cytokine receptor IL-17, which is implicated in diseases like psoriasis and psoriatic arthritis. Current antibody treatments targeting IL-17 are quite effective at treating psoriasis, but they are injectable and lack in convenience. DiCEs candidate would be oral, and the biotech is hoping to top the efficacy of Amgens already approved oral PDE4 inhibitor Otezla.
What were working on is an oral that will work as well as the anti-IL-17 antibodies. So it combines the convenience and safety of something like Otezla with the efficacy of an antibody like Cosentyx, Judice said. The antibodies tell us that IL-17 is exactly the right target.
Since 2017, DiCE has grown from a seven-person, peanut-sized company to a 29-person staff. And in the next 18 months, Judice is looking to bring that number to 58. The biotech inked a $2.3 billion discovery pact with Sanofi years ago, and is currently partnering with them on an I-O small-molecule program that Judice says isnt far behind the IL-17 candidate.
We should be ready to go public with more data on earlier programs over the course of the next 12 months. And then Im really excited about the opportunity to grow the pipeline by adding new programs to it, he said. Thats one of the things that is particularly great, from my perspective, about having RA Capital lead this round.
In addition to RA, Eventide Asset Management, New Leaf Venture Partners, Soleus Capital, Driehaus Capital Management, Osage University Partners and Asymmetry Capital Management, Northpond Ventures, Sands Capital, Sanofi Ventures, Alexandria Venture Investments, Altitude Ventures and Agent Capital also chipped into the Series C.
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DiCE gets its 'library' card ready as it speeds development of DNA database-derived molecules with more investor cash - Endpoints News
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Sparse Eyebrows Treatment, Home Remedies, and Precautions – Healthline
Posted: at 2:34 pm
Big brows are all the rage on runways. But sparse or thinning eyebrows arent uncommon everywhere else. A 2012 research review showed that there are many possible causes of thinning or sparse eyebrows, including:
Lets cover some strategies for filling in and treating eyebrows that have lost some of their fullness.
The easiest way to treat thin eyebrows is to use makeup to make them look thicker and fuller. There are several types of makeup products that you can use to do this, including:
You may want to experiment with a few products, mixing and matching to find the beauty routine that gives you the eyebrow look you want.
To try filling in your eyebrows to make them look fuller, start with these steps:
If you want a remedy thats more permanent than makeup, you can consider these other techniques and treatments for filling in your eyebrows.
You can use semipermanent or permanent hair dye to add a darker pigment to your eyebrows. This can give the illusion of brows that are thicker and fuller.
You can DIY this treatment yourself with drugstore hair dye or go to an esthetician.
A 2017 research review showed that hair loss has been linked to some vitamin deficiencies, including vitamin D and iron deficiencies.
So, it makes sense to think that taking nutritional supplements for vitamin D and iron may help regrow your hair, including at your eyebrows.
Additionally, the same research review above showed that if you dont have a nutritional deficiency, dietary supplements likely wont be effective.
Anecdotally, some essential oils are said to promote hair growth on your head and at your eyebrows.
Be sure to always dilute them with a carrier oil, and do not use oils too close to your eye and on your eyelid. Castor oil and peppermint oil are two anecdotal favorites for hair growth.
Microblading is a cosmetic procedure performed by a licensed provider. The goal of microblading is to make your brows look full and even.
Microblading (and its cousin procedure, nanoblading) does this by making tiny, feather-like strokes that mimic real hair and filling these strokes with a semipermanent pigment.
The results of microblading last 8 to 30 months, after which you will have to get a touch-up if you like the result.
Similar to microblading, microshading is a procedure also performed by a licensed provider.
Unlike microblading, microshading mimics the appearance of a powdered makeup application (in other words, it looks like makeup and not like real eyebrows). Microshading lasts 3 to 6 months.
Semipermanant eyebrow tattoos (such as henna) and regular, permanent tattoos have been around for many years. They often do not look as realistic as microblading.
According to a 2016 study, bimatoprost (Latisse) has not yet been approved by the FDA for the use of eyebrow restoration and would be considered off-label use. The dosage is a topical application to your eyebrows once or twice daily.
This FDA-approved medication for eyelash growth stimulation is by prescription only, and it may take several months to see full results.
Minoxidil (Rogaine) is available as both an over-the-counter and prescription-strength medication. It can be used as a topical foam, a concentrated solution, or be given orally.
In a small 2014 study, 39 participants were asked to use a lotion containing minoxidil on one side of their faces, and a placebo product on the other side in an attempt to treat eyebrow thinning.
The study found that the minoxodil side saw significantly better results than the placebo.
You can talk with a dermatologist or cosmetic surgeon about hair grafts that target your eyebrows. These types of grafts use your existing hair follicles to fill in thin spots and encourage regrowth.
These eyebrow transplant procedures can be quite expensive, require a few weeks of recovery, and there is a risk of serious side effects and infection.
Sparse eyebrows can have several causes.
Overplucking or tweezing your eyebrows can damage your hair follicles and lead to poor hair regrowth. Other causes of sparse eyebrows include:
Hair loss from your eyebrows can be frustrating, but there are lots of available treatments. You can also look into cosmetic procedures and even hair grafts to make your brows look bigger.
If youre concerned about hair loss or cant figure out whats causing it, talk with a doctor.
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Sparse Eyebrows Treatment, Home Remedies, and Precautions - Healthline
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Psoriasis Drugs Market Analysis, Growth Forecast Analysis by Manufacturers, Regions, Type and Application to 2026 – SoccerNurds
Posted: at 2:34 pm
Psoriasis Drugs Market Report offers a comprehensive analysis of the Psoriasis Drugs industry, standing on the readers perspective, delivering detailed market data, and penetrating insights. No matter the client is an industry insider, potential entrant, or investor, the report will provide useful data and information.
Psoriasis Drugs Market Report Summary:
The report demonstrates detailed coverage of thePsoriasis Drugs industry and main market trends. The market research includes historical and forecast data, like demand, application details, price trends, and company shares of the leading Psoriasis Drugs by geography, especially focuses on the key regions like United States, European Union, China, and other regions. This report studies and analyzes the in-depth impact of Coronavirus COVID-19 on the Psoriasis Drugs industry.
In addition, the report provides insight into the main drivers of market demand and strategies of suppliers. Key players are profiled, and their market shares in the global Psoriasis Drugs market are discussed. And this report covers the historical situation, present status, and the future prospects of the global Psoriasis Drugs market.
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Psoriasis Drugs Market: Product Type Segment Analysis (Consumption Volume, Average Price, Revenue, Market Share, and Trend 2016-2026):
Psoriasis Drugs Market: Application Segment Analysis (Consumption Volume and Market Share 2016-2026; Downstream Customers and Market Analysis):
Psoriasis Drugs Market: Regional Segment Analysis (Regional Consumption Volume, Consumption Volume, Revenue, and Growth Rate 2016-2026):
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Psoriasis Drugs Market Research Objectives:
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Global Interleukin Market Analysis, Size, Trends and Forecast to 2026 | Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Asthma – Factory Gate
Posted: at 2:34 pm
United States of America:-The Interleukin market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.
The global Interleukin market size is expected to gain market growth in the forecast period of 2020 to 2026, with a CAGR of xx% in the forecast period of 2020 to 2026 and will expected to reach USD xx million by 2026, from USD xx million in 2019.
Under COVID-19 Outbreak, how the Interleukin Industry will develop is also analyzed in detail in COVID Impact Chapter of this report.
For Better Understanding, Download FREE Sample Copy of Interleukin Market Report(Including full TOC, Graphs, Sample Data, and Tables)@ https://www.marketreportexpert.com/report/Interleukin/36243/sample
Some of top players influencing the Global Interleukin market:
Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Asthma, Inflammatory Bowel Disease (IBD), Others
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Market segmentation
Interleukin market is split by Type and by Application. For the period 2015-2026, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.
Majortype, primarily split into
Pharmaceuticals and Healthcare
Major applications/end users, including
IL-17IL-23IL-1IL-5IL-6Others
Do You Have Any Query Or Specific Requirement? Ask to Our Industry Expert(Note: Our reports include the analysis of the impact of COVID-19 on this industry. Our updated sample pages shows impact of Covid-19 on Industry trends.): https://www.marketreportexpert.com/report/Interleukin/36243/inquiry
This report examines all the key factors influencing growth of global Interleukin market, including demand-supply scenario, pricing structure, profit margins, production and value chain analysis. Regional assessment of global Interleukin market unlocks a plethora of untapped opportunities in regional and domestic market places. Detailed company profiling enables users to evaluate company shares analysis, emerging product lines, scope of NPD in new markets, pricing strategies, innovation possibilities and much more.
The Interleukin market is analysed and market size information is provided by regions (countries).
The key regions covered in the Interleukin market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.
The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026.
Regional analysis is another highly comprehensive part of the research and analysis study of the global Interleukin market presented in the report. This section sheds light on the sales growth of different regional and country-level Interleukin markets. For the historical and forecast period 2015 to 2026, it provides detailed and accurate country-wise volume analysis and region-wise market size analysis of the global Interleukin market.
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What will the market growth rate, growth momentum or acceleration market carries during the forecast period?Which are the key factors driving the Interleukin market?What was the size of the emerging Interleukin market by value in 2020?What will be the size of the emerging Interleukin market in 2026?Which region is expected to hold the highest market share in the Interleukin market?What trends, challenges and barriers will impact the development and sizing of the Global Interleukin market?What is sales volume, revenue, and price analysis of top manufacturers of Interleukin market?What are the Interleukin market opportunities and threats faced by the vendors in the global Interleukin Industry?
The reports conclusion leads into the overall scope of the Global market with respect to feasibility of investments in various segments of the market, along with a descriptive passage that outlines the feasibility of new projects that might succeed in the Global Interleukin market in the near future. The report will assist understand the requirements of customers, discover problem areas and possibility to get higher, and help in the basic leadership manner of any organization. It can guarantee the success of your promoting attempt, enables to reveal the clients competition empowering them to be one level ahead and restriction losses.
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Global Interleukin Market Analysis, Size, Trends and Forecast to 2026 | Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Asthma - Factory Gate
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Psoriasis Treatment Market Share, Demand, New Opportunities and Foresight to 2022 – NeighborWebSJ
Posted: at 2:34 pm
Market Insights:
Psoriasis is a highly common chronic skin condition. Market Research Futures (MRFR) in-depth market report on the global psoriasis treatment market has disclosed that the market is anticipated to witness a promising CAGR of 7.3% during the forecast period of 2016 to 2022. The social stigma and discomfort that is associated with psoriasis is expected to promote swift market growth. Valued at USD 7 Bn at the beginning of 2016, the global market is expected to witness increased revenue which results in an approximate evaluation of over USD 10 bn by the end of the assessment period.
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Rising awareness and screening for psoriasis is the leading factor driving growth in the demand for psoriasis treatment. This chronic condition is exacerbated by several factors which can vary from patient to patient, thus further increasing the demand for appropriate and effective treatment options. Increasing exposure to chemicals and polluted environments have resulted in an increase in the diagnosis of psoriasis. Presently, all treatment options are temporary in nature or need ongoing patient involvement with no concrete cure. Drugs for psoriasis treatment carry a high cost which will hamper market growth. However, increasing adoptions of alternative psoriasis treatments, and the race among market players to develop an effective psoriasis treatment solution will lead to market opportunities.
Key Players:
Market leaders who participate in the competitive landscape of the global psoriasis treatment market include Eli Lilly, Novartis International AG, Johnson & Johnson, Pfizer Inc., Merck and Co Inc., Amgen and AbbVie.
Latest Industry News:
Eli Lilly & Company in Korea has received government approval from the Ministry of Health & Welfare for the reimbursement for its psoriasis treatment drug Taltz.
Market Segmentation:
The global psoriasis treatment market is segmented in MRFRs competitive analysis on the basis of mechanism of action, route of administration, drug types, and region. Based on mechanism of action, the market is segmented into interleukin blockers, phosphodiesterase inhibitors, TNF inhibitors, and others.
By route of administration, the market is divided between oral, injectable, and topical. Oral treatment options are highly popular and capture around 40% of the global market.
On the basis of drug types, the market is segmented into biologics and small molecules.
Globally, the market is divided into the Americas, Europe, Asia-Pacific (APAC), and the Middle East and Africa.
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Regional Analysis:
Due to the presence of North America, the Americas account for the largest share of the global market. The presence of several market players and a high patient population afflicted with psoriasis is expected to lead to increased revenue generated for market growth. Moreover, the awareness about this condition is quite high in the region and has led to an increased demand for effective treatment options. Increasing R&D activities to develop a long-term solution for psoriasis is expected to facilitate market expansion opportunities.
Meanwhile, the Asia Pacific is the fastest growing region due to the swiftly developing healthcare sector and the growing awareness regarding conditions like psoriasis which has resulted in increased demand. The affinity for natural skin care methods is expected to reveal effective alternate treatment strategies that may assist future market growth.
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Psoriasis Treatment Market Share, Demand, New Opportunities and Foresight to 2022 - NeighborWebSJ
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Show Kindness And Volunteer More: New Book Says Improving Human Connections Can Lengthen Life – Here And Now
Posted: January 7, 2021 at 5:44 am
Making New Years resolutions to lose weight, eat more superfoods or exercise may be all well and good. But in terms of living a long life, science writer Marta Zaraska argues those actions wont help you as much as improving connections to other people.
Human contact is crucial for good health, says Zaraska, author of the new book, Growing Young: How Friendship, Optimism and Kindness Can Help You Live to 100. She illustrates this point by explaining how the mind communicates with the body, especially when we are under stress.
In our evolutionary past, being alone usually meant being under stress from potential lurking danger. Humans, innately social beings, evolved to recognize when we are safe with other humans from accidents or predators, she says. One of those adaptations is the hypothalamic-pituitary-adrenal (HPA) axis, she says.
The HPA axis starts with the signal in your brain that tells you that there is a reason to be stressed and then sends a soup of hormones throughout your body, basically one triggering another and so on and so on, she explains.
Those hormones cortisol, known as the stress hormone, or adrenaline ramp up your body to face dangers, she says. But over time, humans stressors have changed dramatically. The HPA axis is now chronically activated by stress points such as finances, work, school or even traffic, she says. That means the hormones are constantly flooding the body, putting us in a perpetual fight or flight mode.
There are detrimental downstream effects from the ceaseless barrage of stress hormones, such as higher risk of diabetes or cardiovascular disease, she says.
But at the same time, so-called social hormones oxytocin, serotonin, endorphins and vasopressin can also be activated when were socially connected to other people. Those also have key impacts on our health, she says.
One example is the Roseto effect. In the early 1960s, a close-knit community in Roseto, Pennsylvania, had a death rate that was about 35% lower than the general U.S. population.
By Western standards, Roseto residents werent particularly healthy people many engaged in drinking, smoking and bad eating habits. There was also nothing unusual about their genes, Zaraska says.
But their deep social connections proved valuable. At the time, no one was dying from heart attacks in Roseto, she says. This attracted scientists to study the population.
Researchers found the Roseto community built on 22 civic organizations for only 2,000 inhabitants and principles of volunteering, taking care of public space and caring for each other actually yielded amazing health, she says.
But researchers also predicted that if Roseto residents lost their communal touch, their overall health would deteriorate, Zaraska says.
Unfortunately, this is exactly what happened generations later in the 70s and 80s and so on, she says. And when people started pursuing the so-called American dream and living in the suburbs, buying cars, working longer hours, they stopped being so connected to their community [and] their health also just went back to American average.
In Growing Young, Zaraska says human connection is not just a want, but a need. Building in-person relationships and being social have all but come to a halt during the COVID-19 pandemic. Zaraska is hopeful this time period of social isolation wont shorten lives because its quite a temporary state.
If the pandemic dragged on for years and years, thats when Zaraska says shed be much more worried.
It is true that we need the connection, she says. Loneliness has very serious detrimental effects on our health. People who are lonely have higher blood pressure.
Fortunately, there are still ways to connect with others during the pandemic, she says. Volunteering in person or online is a great way to boost your health and longevity, she advises, as well as performing acts of kindness.
Engaging in kindness and experiencing empathy cannot be overstated, as Zaraska writes in her book. In collaboration with scientists at Kings College London, she took part in an experiment to measure her cortisol, the stress hormone.
After seven days of performing small acts of kindness and a week of life as usual, she was amazed at the results. She saw measurable differences in her day-to-day. Her levels of cortisol were much better on days where she was kind to others, even if the day was still considerably stressful, she says.
Her results mimicked the positive findings of a research study in California that connected acts of kindness to less bodily inflammation. Study participants did small favors, such as buying a stranger a coffee or letting someone go first in traffic.
Zaraska also writes about dietary fads, including how goji berries arent improving your health in the long term. She argues a healthy, exercise enthusiast who is lonely and antisocial may not live as long as a couch potato with a bountiful social life and a lot of friends.
Of course, the best scenario is when you are socially connected, optimistic, and you eat healthy and exercise, she says. But if something has to give, completely giving up on your social life is not a good health strategy.
Emiko Tamagawaproduced and edited this interview for broadcast withTinku Ray.Serena McMahonadapted it for the web.
By Marta Zaraska
In our culture we tend to think about longevity in terms of healthy food and exercise. Asked in a poll what they were doing to stay healthy, 56 percent of Americans mentioned physical activity and 26 percent watching food/drink. The only category that might have involved boosting relationships or changing mindsets was otherand it got just 8 percent of the vote. We dont realize that volunteering or investing in friendships can help increase our lifespans. Instead, we worry about gluten and obsess about pesticides and mercury in fish. We sign up for Zumba and spinning classes. We search for easy rejuvenating therapies.
The global anti-aging market is already worth upward of $250 billion, and Americans spend more on longevity cures than they do on any other kind of drug, even though most are untested by science. We love pills: about a half of Americans and Canadians take at least one dietary supplement. There are now over 55,000 such products on the US market alone, from moringa leaves to ashwagandha powder. And then, we diet. In one survey, 56 percent of women said they wanted to lose weight to live longer, yet the research on whether this will work is ambiguous.
Of course, eating healthy food and doing sports are important for health and longevity, but not as important as we tend to think (and certainly moringa leaves are not required). Its a bit like with smok- ing and nutrition. Smoking a pack of cigarettes a day is so bad for you that it overshadows the best of diets, but that doesnt mean that non-smokers can rest on their laurels and stuff themselves with junk food. Apart from shunning tobacco, investing in a thriving social life might be the best thing you could do for your longevity. Consider the numbers. Studies show that building a strong support network of family and friends lowers mortality risk by about 45 percent. Exercise, on the other hand, can lower mortality risk by 23 to 33 percent. Eating six or more servings of vegetables and fruits per day, which is admittedly quite a lot, can cut mortality risk by 26 percent, while following the Mediterranean dietso eating lots of fruits and vegetables, whole grains, replacing butter with olive oil, etc.21 percent. Of course, such numbers should be taken with caution, coming as they do from studies with varying methodologies which means they are not straightforward to compare, but they do reveal some important general trends.
In recent years science has begun to unveil how much our minds and bodies are intertwined. Technological advances in molecular biology and brain imaging techniques allow researchers to look deeper into the many links between our
thoughts and emotions and our physiology. The vagus nerve, the social hormones oxytocin and serotonin, the stress axes such as the hypothalamic-pituitary-adrenal axisall of these emerge as the reasons behind why friendships or kindness matter for longevity. Oxytocin, for example, has been linked with our social skills on one hand, and with health on the other. It has anti-inflammatory properties, reduces pain, and helps bone growth, potentially preventing osteoporosis. Studies also show that spraying oxytocin into the nostrils of squabbling married couples makes them more likely to reconcile. It makes us better at reading facial expressions of emotions, and it makes us more trusting. It can even make husbands stand further away from pretty women. Gut microbiota, another link between the body and the mind, play a role in many diseases including diabetes, multiple sclerosis, and allergies, while also affecting emotions and personality. The vagus nerve, the longest of the nerves that emerge directly from the brain, which is responsible for breathing, swallowing, and digestion, has been implicated in sudden psychogenic death reported among the tribes of Africa and the islands of the Pacific.
Marta Zaraska, "Growing Young: How Friendship, Optimism and Kindness Can Help You Live to 100"
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Show Kindness And Volunteer More: New Book Says Improving Human Connections Can Lengthen Life - Here And Now
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What are longevity supplements, and are they safe? – MarketWatch
Posted: at 5:44 am
Aches and pains. A growing waistline. Diminishing eyesight, hearing loss, memory lapses. These are the woes of growing older for some people, once considered inevitable. But recent, exciting discoveries in the fast-growing field of longevity science have some doctors and researchers pronouncing that these symptoms of aging may one day be treatable with pharmaceuticals, gene therapies or other yet-to-be-discovered medical technologies.
Many people havent been content to wait, though. Dozens of commercial producers are selling hundreds of so-called longevity supplements right now, and sales data suggest anawful lot of peopleare trying them. But do they work? Are they even safe?
To find out, we scoured the latest research and interviewed two top scientists in the field. What we learned suggests that you may want to hold off on ordering a supply, or at least do your research very carefully.
There is a solid handful of compounds that look very promising in the scientific quest to slow the aging process. One of the most exciting is nicotinamide adenine dinucleotide, or NAD, which has been shown to extend both the lifespans and youthful function of yeast and animals in clinical trials. Human trials are ongoing, with only a handful published to date.
NAD (also often written as NAD+) is a substance found in every cell in your body, which controls all kinds of metabolic processes, including the regulation of sirtuins, the so-called longevity genes. As you age, your NAD+ levels decline, and scientists think it is perhapsthisdecline that leads toall sortsof other age-related declines.
Also read: Should you invest in the new longevity funds?
The working theory, then, is that if we can boost our NAD+ levels as we age, we can slow our decline tremendously. Lab studies on yeast and rodentslend strong supportto that theory. The most recent studies have primarily involved the administration of either nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), which is then converted into NAD in the body.
To learn more about NAD, Next Avenue talked to Dr. Shin-Ichiro Imai, professor of developmental biology at the Washington University School of Medicine in St. Louis. Along with Leonard Guarente, Imai discovered the link between NAD and sirtuin control in 1999. Hes been studying the molecule ever since.
There have been 10 human clinical trials using NR, most at very high dose, with no safety issues, Imai said. Most of those trials, however, lasted for a duration of weeks or months at most.
Is it safe to take NAD-boosting supplements continuously, for years?
NMN and NR have already been available in Japan and the U.S. since 2015, and some people have been taking it since then, Imai noted. Anecdotally, I havent heard of any side effects from the taking of these supplements.
Some trials, however, have recorded mild side effects including headaches, nausea, diarrhea and skin flushing.
See: 3 aging experts tell how they decided on where to grow older
More troubling, however, is the conclusion of a 2019 study that showed a possible link between elevated levels of NAD and tumor growth in isolated cells and animals. Rugang Zhang, deputy director at the nonprofit Wistar Institute Cancer Center in Philadelphia, was the lead researcher on that study.The study, published in the UK journal Nature Cell Biology, did not find that NAD causes cancer, rather that elevated levelsappeared to accelerateoncogenesis (tumor formation) already in motion.
We dont want to oversell the results of our study, Zhang said. Lots of studies in the literature have clearly demonstrated that as normal cells age, there is lower NAD. So, supplementing NAD could be beneficial. Its possible that NAD boosters could help people live longer and healthier. Were not saying that if people take NAD boosters they will get cancer. This was a very early study on mouse models, and more study is needed.
He suggests a course of action grounded in a deep preponderance of evidence: At the end of the day, we just need more knowledge, through more research. We need the scientific community to come to a consensus. The risk to potential benefit remains to be seen.
Mucking up the risk/benefit ratio further is the fact that supplements are onlyvery lightly regulatedby the U.S. Food and Drug Administration, with the testing, evaluation and labeling of such products left up to manufacturers. This presents another dilemma for those considering longevity supplements: theres no sure way of knowing exactly what youre getting.
The results of the few published human clinical trials to date unequivocally show that taking NR boosts levels of NAD in the body. But apparently, more NAD doesnt translate to more youthful function.
See: There are six types of retirees which are you?
Unfortunately, those studies have not yet shown any significant efficacy, Imai said.
And thats when the substance administered is of lab-grade purity. So what about the typical supplements available online?
There are so many products out there, Imai lamented, particularly for NMN, but Im concerned about the quality.
Indeed, a 2020meta-analysisof NAD trials surmised: it seems likely that side effects linked to interventions that target NAD metabolism more likely arise from impurities rather than the supplements themselves, since this industry generally operates without rigorous control of quality and standardization.
Imais lab has evaluated a number of commercially available NAD-boosting supplements, but found only two of lab-grade purity. Imai wouldnt disclose the names of the products (both Japanese-made), as he doesnt endorse supplements. But he did note that they are extremely expensive.
Dont miss: What is the secret to aging well?
Finally, we asked someone whod taken an NAD-booster to share her experience. Kim Oberdorfer, an air-traffic controller in Oakland, Calif., wasnt impressed.
I took [a popular NR supplement] for about two months and it just gave me these dull headaches. I was having hot flashes last February, and when I told my sister Im 47, shes 53 about how horrified I was to be having them so young, she goes, Are you sure its not just a reaction to an NAD supplement? said Oberdorfer. At the time I wasnt really working out much, but my sleep schedule was really messed up and I heard it was good for that as well. I didnt think it helped at all.
Rashelle Brownis a longtime fitness professional and freelance writer with hundreds of bylines in print and online. She is a regular contributor for NextAvenue and the Active Network, and is the author of Reboot Your Body: Unlocking the Genetic Secrets to Permanent Weight Loss (Turner Publishing). Connect with her on Twitter and Instagram @RashelleBrownMN.
This article is reprinted by permission fromNextAvenue.org, 2021 Twin Cities Public Television, Inc. All rights reserved.
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What are longevity supplements, and are they safe? - MarketWatch
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