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Category Archives: Transhuman News

Europeans Recognize Trumpism for What It Is – The Atlantic

Posted: January 13, 2021 at 4:20 pm

I called Asselborn to ask him what he thought about all of this. He apologized for his English (I have to speak Luxembourgish in the morning, read the papers in German, talk to diplomats in French and now to you in English. Its a lot.) and was somewhat bemused by the fuss, but agreed to a brief interview. The following transcript has been condensed and edited for clarity.

Anne Applebaum: So what happened?

Jean Asselborn: Nothing, really. The U.S. ambassador in Luxembourg told us that Pompeo has a meeting with [NATO Secretary General] Jens Stoltenberg on the 14th, and that he would like to stop by Luxembourg too. We were waiting to hear details. And then Sunday evening we were told Pompeo will not come.

Applebaum: Do you know why?

Asselborn: Nobody spoke with me, but The New York Times seems to think it was my comments, so that must be the reason. We also heard that in Brussels they were planning to meet with him, but without any press conference or public statement; maybe that bothered him too? I did call Trump Brandstifter, pyromaneI think it means pyromaniac in English. From my side, this is correct, and I will not correct this.

Applebaum: Had you met Pompeo before?

Asselborn: I met him once in Washington and saw him several times in Europe. It was never easy with him.

Applebaum: What does that mean?

Asselborn: I heard Trump twice at the UN General Assembly, both times speaking about this wrong idea of patriotism. It wasughawful. In the 1930s, in Europe, we learned where this wrong patriotism can go. We never understood it. A big majority in the EU never understood it. But Pompeo was always repeating this too.

Applebaum: He was an emissary of Trumpism?

Asselborn: He was somebody who defended the positions of Trump. Very difficult cooperation with him. Pompeo is really one of the last pillars of Trump. In a week, it will be better.

Applebaum: What lasting damage did the Trump administration do?

Asselborn: I am not defending Iran. On human rights, Iran is catastrophic. But we negotiated with them for 13 years, and finally in 2015 we got the deal that Iran could not build nuclear weapons. The idea was to engage and change this regime. I was twice in Iran, in 2015 and 2016young people expected something from the free world; now that is all destroyed. Trump destroyed this. He destroyed solidarity with the Paris climate agreement. He did all of these aggressive things on trade. He left the World Health Organization.

I dont know of one positive thing on foreign policy that has come out of EU-U.S. cooperation during the past four years. I dont see one single positive thing. It would be healthy to have again a president and a secretary of state who understand the past, the history of the European Union, who know that before World War II we had exactly this wrong sort of patriotism, nationalism, racism. The EU was created to help us to overcome this wrong patriotism.

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Commentary: Health experts and other San Diego leaders must unite to better coordinate pandemic response – The San Diego Union-Tribune

Posted: at 4:20 pm

Watching frontline health care workers and other volunteers receive their first doses of the COVID-19 vaccine, there is reason to believe after months of uncertainty that this pandemic will indeed end. The challenge now, though, is to keep ourselves safe until enough of us have been inoculated and possess protective immunity.

It will not be easy. As we write this, more than 21 million Americans have been diagnosed with the coronavirus that causes COVID-19, and more than 365,000 have died. Across the nation, hospital intensive care units are at or even beyond capacity. In California, state officials have ordered thousands of additional body bags and refrigerated storage units to serve as portable morgues. San Diego County escaped the worst of the summer COVID-19 surge, but the current situation is not good. Case and mortality rates in the county continue to rise, each day seemingly worse than the last. Our hospitals and health systems are stressed to the breaking point.

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But we are fortunate that the countys hospitals have a long history of close cooperation and coordination and that they have worked through these difficult times to provide and process lab tests, review predictions for hospital needs and revamp in-patient processes to effectively meet ever-increasing patient loads and needs.

In addition to its strong Health & Human Services Agency, San Diego County enjoys abundant public health expertise at San Diego State University, University of California San Diego and other local institutions. Experts at these institutions have been involved from the beginning in helping predict and map viral spread and supporting county contact tracing efforts, and they have offered guidance and services to other institutions, such as local school systems. The pandemic has strengthened and deepened these inter-institutional partnerships and called on us to find new ways to prioritize the needs and health of those most vulnerable.

But more can be done, and more could be better coordinated, including nationwide public health efforts to provide messaging aimed at reducing transmission through early diagnosis, case investigation and contact tracing. We offer some suggestions on how.

Efforts must shift to prioritizing the rapid identification of cases among those who have symptoms or have known exposures, so they can be isolated and treated if positive. The focus needs to be on making sure that those who have positive tests are quickly informed and appropriate actions taken to prevent further spread of the disease, with contact tracing performed only for cases with a high risk of spread to multiple individuals. Finally, but no less importantly, we must reimagine the public health messages about facial coverings and distancing so that they resonate in a time when we are grappling with frustration and fatigue.

Public health professionals at UCSDs Herbert Wertheim School of Public Health and Human Longevity Science and the SDSU School of Public Health urgently call for a convening of stakeholders to discuss how we can pool and reallocate resources at institutions across San Diego County to meet the current crisis. We must prioritize our needs based on the most acute stresses to systems, institutions and communities. We must come together with tangible offers of available capacity to test, trace and treat our families, friends and neighbors and new, innovative ideas for effective prevention strategies and public health messaging that connects us all.

We can do this. UC San Diego alone has the capacity to conduct at least 10,000 COVID-19 tests per day. It conducts routine testing of thousands of on-campus students and staff every week and, under contract from the county, has traced thousands of COVID-19 contacts. Similarly, SDSU, which has developed exceptional skills in community health worker-led contact tracing and testing through its Communities Fighting COVID! program, could expand it to meet near-term needs throughout the region. Immediate efforts should be directed to reaching positive cases within 24 hours. This may require shifting of staffing priorities to ensure prompt containment of COVID-19. Our local universities have deep knowledge about public health messaging and communication, which could be leveraged to create new connections to populations at greatest risk.

It is critical that we identify and consider possibilities now before we find ourselves overwhelmed. Lets bring our strengths to a virtual table so that we those of us with the most protections and those of us with the least outlast these dark times and reach a brighter future of immunity.

Anderson is dean of the Herbert Wertheim School of Public Health and Human Longevity at UC San Diego and lives in Del Mar. Madanat is a distinguished professor of public health and interim vice president for research and innovation at SDSU. She lives in Sabre Springs.

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Commentary: Health experts and other San Diego leaders must unite to better coordinate pandemic response - The San Diego Union-Tribune

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Is it Time to Rethink Gilt Development? – Pork Magazine

Posted: at 4:20 pm

Sow mortality has been making the headlines as producers grapple with rising sow death loss in the U.S. pork industry. Although the topic deserves discussion, some experts believe it is time to focus on gilt retention.

Sow mortality has been scrutinized ad nauseum, but gilt retention hasn't been focused on quite as much. I think it may be the top of the bottleneck when it really comes back to what we can do to improve things downstream in production, said Hyatt Frobose, USA commercial director at Jyga Technologies-Gestal, during a recent webinar.

In a 2003 study published by Ken Stalder at Iowa State University that was reiterated in 2017, it showed on average, replacement females failed to generate a positive return on investment until parity three to four, depending a little on farm size and conditions, Frobose explained.

In general, our females aren't really paying for themselves until they've stayed in the herd for three parities, he said. What's concerning to me is we know that the parity averages for the U.S. sow herd, as represented by Agristats and Swine Management Systems, are only averaging about 2.4 to 2.6. So somewhere, we're not really matching up with when these sows are paying for themselves. It seems to me we're leaving opportunity on the table.

How can we get these animals into their most productive parities?

In North America, most growing gilts are housed in similar housing environments compared to their growing-finishing counterparts. Ad libitum feed access is provided until just prior to breeding, with most gilts receiving diets with marginally elevated levels of amino acids, vitamins and trace minerals. While this rearing strategy is prevalent due to convenience, consistency and availability, recent research suggests it may not necessarily be best for sow longevity. Frobose suggests its time to rethink how gilts are raised and developed.

Limit-Feed GiltsMost of the farms Frobose works with provide ad libitum feed access for gilts from the time they enter the gilt development unit (GDU) until they move into breeding stalls. He said a common issue in commercial GDUs is that gilts grow too fast and are bigger than ideal. Research indicates these gilts are more likely to prematurely exit the herd.

Frobose offered producers two suggestions to help optimize gilts, as they move into breeding.

1. Change feed presentation method. Change feed presentation method to moderately restrict gilts from the end of the nursery period by targeting gains of 1.65 lb/day to1.76 lb/day until flushing two weeks prior to breeding.

2. Change the feed composition. If ad libitum feeding is the only option, add fiber, increase micron size and adjust energy and lysine targets downward by 10% to 15% in order to slow growth rate.

Controlling gilt weight at breeding may also offer downstream diet savings, by moderating mature sow size and reducing annual maintenance costs. Simple math would suggest that reducing gestation feed by as little as 150 g/d could reduce annual feed costs by USD $9/sow/year, Frobose said.

Revisit GDU DesignGDU design is often an afterthought in sow farm design, Frobose said.

It's human nature to lay out your ideal floor plan and equipment and technology. Then, when you get down to the price tag, we try to figure out where we can shave off some dollars and cents to make it more palatable, Frobose said. Unfortunately, in my experience, the GDU becomes a target area that gets the axe on some extra dollars and cents. I think that's unfortunate, because we really should be treating that as the proving ground for the next gilts that are going to be entering the herd.

GDUs are often designed like a grow-finish environment. Frobose said this may be convenient and easier, but he argued it may not be best for the gilt long-term.

Clearly, were getting these gilts to grow fast enough, and we don't really need them to grow any faster than they already are, he said. So, if we're ad lib feeding in the GDU (which I think needs questioned), are wet-dry feeders the right way to go to maximize growth, or would we be better off with a dry feeder that can maybe help us slow down that growth just a little to keep gills from getting too big?

Frobose suggested producers implement these ideas into GDU design.

1. Mimic the environment of the sow farm. Frobose suggested using the same flooring and maintaining the same type of ambient temperature environment and air quality to prepare gilts for moving into the actual sow farm flow. Avoid creating new stresses as they move into the breeding environment.

Waterers are a big thing that Ive seen messed up, Frobose said. Its easy to make the mistake of having a different waterer type in the GDU pens, or even in gestation, than what those gilts will experience in farrowing. I can count too many times where I've seen a gilt that didn't find the water or know how to drink when she got into farrowing. That can really set her on the wrong path as she enters production.

2. Maintain group cohesiveness. If possible, maintain the hierarchy of a group of gilts that were raised together by keeping them together as they move from breeding into pen gestation to minimize aggression and lameness. Research shows grouping gilts or even gilts and P1s separately from older sows can increase farrowing rates and help improve retention of those animals in the herd, he added.

GDUs are continuous flow and that's one of the key differences from most grow-finish environments that are managed all-in, all-out. It's always a challenge of how to optimize stocking density with our different age groups, he said. But its something we've got to continue to think about.

3. Consider precision feeding technology. Most would agree its best to give gilts multiple diets throughout the grow-finish period, Frobose said.

Unfortunately, in my experience, the in-herd nutritionists are usually the last people asked on pen design or barn design for GDUs, and so they end up kind of effectively hamstringed by whatever the construction folks decide is the best thing for the GDU, he added.

Additional feed systems usually require more gilt movement, increasing labor requirements that are already lacking in the GDU. Frobose said blending technologies, however, can enhance pen flexibility and help deliver multiphase diets to a pen of gilts based on their age and weight while reducing diet cost and increasing feed efficiency.

Invest WiselyGilts may have historically been thought of as a cheap investment, but as an industry, we have become accustomed to introducing gilts at an average of 70% to breed at a 55% annual replacement rate, Frobose explained.

In a 2019 study, Derald Holtkamp, Iowa State University, showed that implementing a gilt management program yielded a 10% reduction in annual gilt replacement rate (62% to 52%) on a 2,400-head sow farm and resulted in 829 additional marketed pigs and 222,310 additional pounds of pork produced per year, ultimately yielding a benefit-to-cost ratio of 2.41:1.

Once you account for genetic premiums, overhead costs and the currently low value of cull sows, isnt it worth realigning your gilt development programs to improve herd retention? Frobose asked.

More from Farm Journal's PORK:

A Look at the Unknown Factors in Sow Mortality

No Magic Bullet to Reduce Pre-Wean Mortality in Pigs

Remodeling Facilities: You Have Options

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Live longer: Chlorophyll reduces cancer risk and promotes liver health to boost longevity – Express

Posted: at 4:20 pm

Chlorophyll is a pigment present in all green plants and a few other organisms. It is required for photosynthesis, which is the process by which light energy is converted into chemical energy. According to health experts, chlorophyll should be part of our daily lives and with the numerous health benefits its easy to see why.

Chlorophyll contains vitamins, antioxidants, and therapeutic properties that all majorly benefit the body.

Dr Keith Kantor, nutritionist and dietician and CEO of the Nutritional Addiction Mitigation Eating and Drinking program said: Chlorophyllsuppresses appetite, aids in weight loss, decreases spikes in insulin which lessens cravings, helps with skin healing, helps in detoxifying the blood, reduces the risk for cancer, increases energy, helps in eliminating odours (as a natural deodorant), and helps in boosting the immune system.

People have used chlorophyll as a health supplement for many years.

A variety of medical studies have suggested that it may be helpful for skin conditions, body odours, and fighting certain kinds ofcancer.

READ MORE:How to live longer: Consume this spice to reduce heart disease risk and inhibit cancer

In a study published in the US National Library of Medicine National Institutes of Health, chlorophylls ability to extend lifespan was investigated..

Results of the study indicate that chlorophyll is absorbed by worms and is thus bioavailable, constituting an important prerequisite for antioxidant and longevity-promoting activities inside the body, noted the study.

It continued: Our study thereby supports the view that green vegetables may also be beneficial for humans.

In conclusion, our experiments demonstrate that chlorophyll exhibits substantial antioxidant activity and significantly improves antioxidant resistance ofC. elegans.

Therefore, dietary chlorophyll derivatives support the recommendation of nutritionists to eat green vegetables and salads containing high contents of chlorophyll, as this could also help to improve human health and prevent diseases.

In another study published in Science Alert, the effects of chlorophyll on body functioning and blood glucose levels were analysed.

The study noted: Blood glucose levels can be affected by the various types of chlorophyll.

Experiments have proven that chlorophyll has antioxidant activities that are present in various foods.

A diet rich in chlorophyll led to a slight decrease in the number of white blood cells, haematocrit, haemoglobin and an increase in red blood cells compared with control.

It is concluded that chlorophyll is likely to have important implications regarding blood sugar and has benefits in body weight with further studies being warranted.

In addition to its neuroprotective and appetite-suppressing effects, chlorophyll promotes liver health and balances the gut flora.

A recent study posted in Frontiers in Physiology in 2018 has found that chlorophyllin may help relieve hepatic fibrosis symptoms by reducing harmful gut bacteria.

The study also indicates that chlorophyllin may reduce liver inflammation and protect the small intestine in mice with hepatic fibrosis.

Its beneficial effects on the gut microbiota hold promise for future research.

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WISeKey develops WISeToken utility token, a blockchain-based asset for drones and robots to secure IoT interactions (drone-to-drone or…

Posted: at 4:20 pm

WISeKey develops WISeToken utility token, a blockchain-based asset for drones and robots to secure IoT interactions (drone-to-drone or people-to-drone), recognize and trust each other

WISeTokens will not be listed on secondary markets, will not be subjected to price fluctuations, and will be sold on a fixed price basis

Geneva January 13, 2020 - WISeKey International Holding Ltd (WISeKey, SIX: WIHN / Nasdaq: WKEY), a leading cybersecurity, AI and IoT company, today announced that it has developed WISeToken utility token, a blockchain-based asset to be used by drones and robots to secure IoT interactions (drone-to-drone or people-to-drone) and to recognize and trust each other. The WISeKey Validation Service (the certificates validation authority), using the WISeKey Public Key Infrastructure, analyses WISeToken digital certificates to recognize and trust the identity of the drone and other parties these drones interact with, and mitigate malicious actors and hackers from compromising interactions.

According to the FAA, commercial and recreational drone market continues to increase. The number of commercial drones in use in the U.S. is expected to reach 835,000 aircraft in use by 2023. Commercial drones, which are used for research, pilot training, filming, building inspection and a slew of other professional activities, are typically more expensive and robust than the model aircraft used by hobbyists. The number of recreational drones in use across the U.S. is expected to reach 1.4 million by 2023.

WISeKey offers a service to authenticate and validate each drone to allow the exchange of information or value with each other. This Tokenization capability is a way to answer the regulatory FAAs Remote ID requirement that will require every drone sold in the U.S. that weighs more than 0.55 pounds to be equipped with secured and trusted capabilities to broadcasts its location and identification to local authorities. One way to think of the technology is as a digital license plate for drones.

WISeTokens are sold directly by WISeKey as a utility token and generates revenue as a hybrid product/service offering. WISeTokens will not be listed on secondary markets, will not be subjected to price fluctuations, and will be sold on a fixed price basis.

The WISeKey Validation Service offer objects the ability to send the validation authority the third partys Public Key and the Digital Certificate for validation. WISeKey checks that the corresponding Public Key holds a valid WISeToken and if so, the identity is verified. In order to get the verification, the object making the request needs to hold at least 1 WISeToken in its wallet, which is valid for 12 months or 100 requests. WISeKey can, over time, adjust the number of utility tokens required to get verified, the longevity of the token and entitled verifications per token.

The WISeKey Validation Service is used for the verification of the validity of digital identity of the drone in real time, thus ensuring secure use of digital identities for authentication of any drone connected to the internet and the activation of attributes such as digital signing, transactions, or sending data.

The WISeKey Validation Service is suitable for all e-services that can be used with a WISeToken. Each validation will be charged with a WISeToken that will represent a fraction of the transaction validation fee equivalent to 0.001 cents of dollar.

The WISeKey platform is Blockchain neutral and allows Blockchain configurations to benefit greatly by the use of secure private keys instead of public keys currently used. Private keys secure data and transactions which can be only conducted between authenticated parties thus making it a very viable option for any sort of IoT transaction imaginable. Drones equipped with WISeKeys Secure Element, called VaultIC184, consists of a tamper resistant silicon chip, based on a state-of-the-art secure microcontroller chip which can be easily integrated to the device by its manufacturers.

For more information on WISeKeys IoT security offerings please visits: https://www.wisekey.com/solutions/iot-connected-devices/iot-security/

About WISeKey

WISeKey (NASDAQ: WKEY; SIX Swiss Exchange: WIHN) is a leading global cybersecurity company currently deploying large scale digital identity ecosystems for people and objects using Blockchain, AI and IoT respecting the Human as the Fulcrum of the Internet. WISeKey microprocessors secure the pervasive computing shaping todays Internet of Everything. WISeKey IoT has an install base of over 1.5 billion microchips in virtually all IoT sectors (connected cars, smart cities, drones, agricultural sensors, anti-counterfeiting, smart lighting, servers, computers, mobile phones, crypto tokens etc.). WISeKey is uniquely positioned to be at the edge of IoT as our semiconductors produce a huge amount of Big Data that, when analyzed with Artificial Intelligence (AI), can help industrial applications to predict the failure of their equipment before it happens.

Our technology is Trusted by the OISTE/WISeKeys Swiss based cryptographic Root of Trust (RoT) provides secure authentication and identification, in both physical and virtual environments, for the Internet of Things, Blockchain and Artificial Intelligence. The WISeKey RoT serves as a common trust anchor to ensure the integrity of online transactions among objects and between objects and people. For more information, visitwww.wisekey.com.

Press and investor contacts:

Disclaimer:This communication expressly or implicitly contains certain forward-looking statements concerning WISeKey International Holding Ltd and its business. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of WISeKey International Holding Ltd to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. WISeKey International Holding Ltd is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

This press release does not constitute an offer to sell, or a solicitation of an offer to buy, any securities, and it does not constitute an offering prospectus within the meaning of article 652a or article 1156 of the Swiss Code of Obligations or a listing prospectus within the meaning of the listing rules of the SIX Swiss Exchange. Investors must rely on their own evaluation of WISeKey and its securities, including the merits and risks involved. Nothing contained herein is, or shall be relied on as, a promise or representation as to the future performance of WISeKey.

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8 celebrities in their 90s share thoughts on living a fulfilling life – Marin Independent Journal

Posted: at 4:20 pm

Photo by Frederick M. Brown/Getty Images

Get at least eight hours of beauty sleep, nine if youre ugly," jokes Betty White.

Mel Brooks promotes outrageous humor. (Photo by Chris Pizzello/Invision/AP, File)

Ive never been particularly aware of my age," says actress Angela Lansbury, age 95. "It's like being on a bicycle I just put my foot down and keep going. (Photo by Richard Shotwell, Invision/AP)

I actually look for things to smile about," says Dr. Ruth Westheimer. (Photo by Dia Dipasupil/Getty Images)

For a long and good life, Dick Van Dyke suggests that you sing, dance and laugh everyday. (Photo by John Salangsang/Invision/AP, File)

Iris Apfel, age 99, is a businesswoman, interior designer, model and considered the worlds oldest fashion icon. (Magnolia Pictures)

In 2017, HBO presented a documentary entitled If Youre Not in the Obit, Eat Breakfast that confronted stereotypes about life after age 90. In the film, Carl Reiner has a conversation with several of his friends from show business, challenging what it means to really live in your 90s.

Reiner, the legendary comedian, director and screenwriter, offers himself as Exhibit A at age 95. (Reiner died in June 2020 at age 98.) He spoke with other legendary comedians: Filmmaker and funnyman Mel Brooks, age 90; TV icon Norman Lear, age 95; and beloved performer Dick van Dyke, age 91.

Comedy is part of these mens work. Humor can be used as a teaching tool, although it is unlikely that is the intention of these notables. Yet, here are some messages we can extract from these talented funny men, taken from the HBO documentary, and some wisdom from four dynamic women in their 90s.

Carl Reiner

Carl Reiner celebrates humor.Reiner had a running quip about being in his nineties. Every morning, I pick up my newspaper, get the obituary section and see if Im listed, he said. If Im not, I have my breakfast.

What we know: A sense of humor is related to longevity. Adults with an average sense of humor live longer than those who dont find humor in life, according to researchers. Benefits include decreased blood pressure while laughter boosts the immune system by decreasing the stress hormone cortisol and minimizing inflammation.

Norman Lear

Norman Lear talks about cultureand flexibility.I think the culture stereotypes everything, said Lear. Because Im 93, Im supposed to behave in a certain way. The fact I can touch my toes shouldnt be so amazing to people.

What we know: Society seems to have some unrealistic expectations about ones age and respective appearance, activities and capabilities. Not to be overlooked is Lears ability to touch his toes, demonstrating flexibility typically achieved with physical activity. Such activity improves our ability to perform daily physical activities, improves our range of motion and increases our sense of balance, helping us avoid falling and injuries.

Dick Van Dyke

Dick Van Dyke suggests dance and song.For a long and good life, Van Dyke suggests that you sing, dance and laugh everyday. Without knowing his daily routine, we do know in 2018 Van Dyke played the older cantankerous banker, Mr. Dawes in the movie Mary Poppins Returns. He not only danced and sang but jumped on a desk, did a tap dance number and jumped down with a spring and a bounce. Dancing has been found to have results comparable to formal exercise improving emotional, psychological and physical well-being. And its fun!

Mel Brooks

Mel Brooks promotes outrageous humor.During the HBO show, Brooks stood up and told the crowd, Ladies and gentlemen, the greatest cat sound in the world, as he broke out into the loudest yowl. As the audience howled, he said, What the hell do you want? Youre not paying a penny here.

Reiner refers to him as the funniest human being in the world. Age and outrageous are terms typically not paired together., but there is a book titled, Be an Outrageous Older Woman by Ruth Harriet Jacobs. Sometimes outrage is needed to get attention.

At the time of this HBO program, all four men continued to work at a craft and art they loved. And herein lies a message. Having a sense of purpose is a lifesaver; humor is a healer helping us keep a perspective. And laughing is healthy. So, think about ways to do something you love to do, keep your sense of humor, have a good laugh and even do a little dance while taking a break from the news.

Angela Lansbury

Age doesnt matter according to Angela Lansbury. Lansbury, age 95, has been on stage, television and in films for more than 70 years, never permitting her chronological age to hold her back. She has said, Ive never been particularly aware of my age. Its like being on a bicycle I just put my foot down and keep going.

What we know. During childhood, there are expected age-related milestones in a childs development, such as when the child walks, talks and can read. Thats not the case for older adults. Expectations about how older adults look, behave and think are not based on developmental stages but on social expectations which often is an excuse for ageism. Most older adults keep going regardless of their age.

Betty White

Betty White advocates getting enough sleep. As a 98-year old actress and comedian, White has a television career spanning 80 years and has worked longer in the industry than anyone else. In promoting sleep, she says, Get at least eight hours of beauty sleep, nine if youre ugly.

What we know: Sleep is considered an important part of our routine and is essential for survival as is food and water. Recent research suggests that sleep has a housekeeping role by removing toxins in our brain that accumulate when we are awake. For older adults, less than seven hours of sleep a night generally is considered insufficient.

The American Academy of Sleep Medicine refers to a study by UCLA researchers who discovered that just a single night of insufficient sleep can make older adults cells age quicker. For a good read on sleep, see The Sleep Revolution: Transforming Your Life One Night at a Time by Arianna Huffington (Harmony Books, 2017).

Iris Apfel

Iris Apfel believes in authenticity. Apfel, age 99, is a businesswoman, interior designer, model and considered the worlds oldest fashion icon. She describes herself as a geriatric starlet, known for her brightly colored clothing, layered jewelry and oversized glasses. There is even a Barbie doll modeled after her. She says, When you dont dress like everyone else then you dont have to think like everyone else. She adds, I always dressed for myself and dont care what anybody thinks.

What we know:With age we have the opportunity to become more of ourselves and less reliant on fulfilling expectations of others. Authenticity refers to the characteristics, roles or attributes that define who we are, even if they are different from how we may act.With age there is a tendency to see ourselves as more authentic, according to researchers Elizabeth Seto and Rebecca J. Schlegel.

Dr. Ruth

Dr. Ruth views life in a positive way. Ruth Westheimer, age 92, is a sex therapist, author, media personality and talk-show host. She says, I actually look for things to smile about. In a 2019 interview she indicated as a Holocaust survivor, she defused anxiety and shame by focusing on the present and using humor and charm.

What we know: Having a positive attitude not only makes us feel good, it effects our longevity. A study from the Boston University School of Medicine found that after decades of research, those who were more optimistic about life lived longer, often to age 85 and older. Researchers suggest several reasons. More optimistic people may be able to regulate their emotions and behavior more effectively as well as their ability to bounce back from difficult situations. Furthermore, they may have healthier lifestyle habits.

These men and women in their 90s have lived and seen a lot. During the current climate, some of their tips might be useful: Dont let age hold you back, stay positive and authentic and of course, get enough sleep. Above all, stay safe and be well and kind to yourself and others.

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CRISPR and the Splice to Survive – The New Yorker

Posted: at 4:17 pm

Odin, in Norse mythology, is an extremely powerful god whos also a trickster. He has only one eye, having sacrificed the other for wisdom. Among his many talents, he can wake the dead, calm storms, cure the sick, and blind his enemies. Not infrequently, he transforms himself into an animal; as a snake, he acquires the gift of poetry, which he transfers to people, inadvertently.

The Odin, in Oakland, California, is a company that sells genetic-engineering kits. The companys founder, Josiah Zayner, sports a side-swept undercut, multiple piercings, and a tattoo that urges: Create Something Beautiful. He holds a Ph.D. in biophysics and is a well-known provocateur. Among his many stunts, he has coaxed his skin to produce a fluorescent protein, ingested a friends poop in a D.I.Y. fecal-matter transplant, and attempted to deactivate one of his genes so that he could grow bigger muscles. (This last effort, he acknowledges, failed.) Zayner calls himself a genetic designer and has said that his goal is to give people access to the resources they need to modify life in their spare time.

The Odins offerings range from a Biohack the Planet shot glass, which costs three bucks, to a genetic engineering home lab kit, which runs almost two thousand dollars and includes a centrifuge, a polymerase-chain-reaction machine, and an electrophoresis gel box. I opted for something in between: the bacterial CRISPR and fluorescent yeast combo kit, which set me back two hundred and nine dollars. It came in a cardboard box decorated with the companys logo, a twisting tree circled by a double helix. The tree, I believe, is supposed to represent Yggdrasil, whose trunk, in Norse mythology, rises through the center of the cosmos.

Inside the box, I found an assortment of lab toolspipette tips, petri dishes, disposable glovesas well as several vials containing E. coli and all Id need to rearrange its genome. The E. coli went into the fridge, next to the butter. The other vials went into a bin in the freezer, with the ice cream.

Genetic engineering is, by now, middle-aged. The first genetically engineered bacterium was produced in 1973. This was soon followed by a genetically engineered mouse, in 1974, and a genetically engineered tobacco plant, in 1983. The first genetically engineered food approved for human consumption, the Flavr Savr tomato, was introduced in 1994; it proved such a disappointment that it went out of production a few years later. Genetically engineered varieties of corn and soy were developed around the same time; these, by contrast, have become more or less ubiquitous.

In the past decade or so, genetic engineering has undergone its own transformation, thanks to CRISPRshorthand for a suite of techniques, mostly borrowed from bacteria, that make it vastly easier for biohackers and researchers to manipulate DNA. (The acronym stands for clustered regularly interspaced short palindromic repeats.) CRISPR allows its users to snip a stretch of DNA and then either disable the affected sequence or replace it with a new one.

The possibilities that follow are pretty much endless. Jennifer Doudna, a professor at the University of California, Berkeley, and one of the developers of CRISPR, has put it like this: we now have a way to rewrite the very molecules of life any way we wish. With CRISPR, biologists have already createdamong many, many other living thingsants that cant smell, beagles that put on superhero-like brawn, pigs that resist swine fever, macaques that suffer from sleep disorders, coffee beans that contain no caffeine, salmon that dont lay eggs, mice that dont get fat, and bacteria whose genes contain, in code, Eadweard Muybridges famous series of photographs showing a horse in motion. Two years ago, a Chinese scientist, He Jiankui, announced that he had produced the worlds first CRISPR-edited humans, twin baby girls. According to He, the girls genes had been tweaked to confer resistance to H.I.V., though whether this is actually the case remains unclear. Following his announcement, He was fired from his academic post, in Shenzhen, and sentenced to three years in prison.

I have almost no experience in genetics and have not done hands-on lab work since high school. Still, by following the instructions that came in the box from the Odin, in the course of a weekend I was able to create a novel organism. First I grew a colony of E. coli in one of the petri dishes. Then I doused it with the various proteins and bits of designer DNA Id stored in the freezer. The process swapped out one letter of the bacterias genome, replacing an A (adenine) with a C (cytosine). Thanks to this emendation, my new and improved E. coli could, in effect, thumb its nose at streptomycin, a powerful antibiotic. Although it felt a little creepy engineering a drug-resistant strain of E. coli in my kitchen, there was also a definite sense of achievement, so much so that I decided to move on to the second project in the kit: inserting a jellyfish gene into yeast in order to make it glow.

The Australian Centre for Disease Preparedness, in the city of Geelong, is one of the most advanced high-containment laboratories in the world. It sits behind two sets of gates, the second of which is intended to foil truck bombers, and its poured-concrete walls are thick enough, I was told, to withstand a plane crash. There are five hundred and twenty air-lock doors at the facility and four levels of security. Its where youd want to be in the zombie apocalypse, a staff member told me. Until recently, the center was known as the Australian Animal Health Laboratory, and at the highest biosecurity levelBSL-4there are vials of some of the nastiest animal-borne pathogens on the planet, including Ebola. (The laboratory gets a shout-out in the movie Contagion.) Staff members who work in BSL-4 units cant wear their own clothes into the lab and have to shower for at least three minutes before heading home. The animals at the facility, for their part, cant leave at all. Their only way out is through the incinerator is how one employee put it to me.

About a year ago, not long before the pandemic began, I paid a visit to the center, which is an hour southwest of Melbourne. The draw was an experiment on a species of giant toad known familiarly as the cane toad. The toad was introduced to Australia as an agent of pest control, but it promptly got out of control itself, producing an ecological disaster. Researchers at the A.C.D.P. were hoping to put the toad back in the bottle, as it were, using CRISPR.

A molecular biologist named Mark Tizard, who was in charge of the project, had agreed to show me around. Tizard is a slight man with a fringe of white hair and twinkling blue eyes. Like many of the scientists I met in Australia, hes from somewhere elsein his case, England. Before getting into amphibians, Tizard worked mostly on poultry. Several years ago, he and some colleagues at the center inserted a jellyfish gene into a hen. This gene, similar to the one I was planning to plug into my yeast, encodes a fluorescent protein. A chicken in possession of it will, as a consequence, emit an eerie glow under UV light. Next, Tizard figured out a way to insert the fluorescence gene so that it would be passed down to male offspring only. The result is a hen whose chicks can be sexed while theyre still in their shells.

Tizard knows that many people are freaked out by genetically modified organisms. They find the idea of eating them repugnant, and of releasing them into the world anathema. Though hes no provocateur, he, like Zayner, believes that such people are looking at things all wrong. We have chickens that glow green, Tizard told me. And so we have school groups that come, and when they see the green chicken, you know, some of the kids go, Oh, thats really cool. Hey, if I eat that chicken, will I turn green? And Im, like, You eat chicken already, right? Have you grown feathers and a beak?

Anyway, according to Tizard, its too late to be worried about a few genes here and there. If you look at a native Australian environment, you see eucalyptus trees, koalas, kookaburras, whatever, he said. If I look at it, as a scientist, what Im seeing is multiple copies of the eucalyptus genome, multiple copies of the koala genome, and so on. And these genomes are interacting with each other. Then, all of a sudden, ploomph, you put an additional genome in therethe cane-toad genome. It was never there before, and its interaction with all these other genomes is catastrophic. It takes other genomes out completely. He went on, What people are not seeing is that this is already a genetically modified environment. Invasive species alter the environment by adding entire creatures that dont belong. Genetic engineers, by contrast, just alter a few stretches of DNA here and there.

What were doing is potentially adding maybe ten more genes onto the twenty thousand toad genes that shouldnt be there in the first place, and those ten will sabotage the rest and take them out of the system and so restore balance, Tizard said. The classic thing people say with molecular biology is: Are you playing God? Well, no. We are using our understanding of biological processes to see if we can benefit a system that is in trauma.

Formally known as Rhinella marina, cane toads are a splotchy brown, with thick limbs and bumpy skin. Descriptions inevitably emphasize their size. Rhinella marina is an enormous, warty bufonid (true toad), the U.S.Fish and Wildlife Service notes. The U.S.Geological Survey observes that large individuals sitting on roadways are easily mistaken for boulders. The biggest cane toad ever recorded was fifteen inches long and weighed six poundsas much as a chubby chihuahua. A toad named Big Bette, who lived at the Queensland Museum, in Brisbane, in the nineteen-eighties, was nine and a half inches long and almost as wideabout the size of a dinner plate. The toads will eat almost anything they can fit in their oversized mouths, including mice, dog food, and other cane toads.

Cane toads are native to South America, Central America, and the southernmost tip of Texas. In the mid-eighteen-hundreds, they were brought to the Caribbean. The idea was to enlist the toads in the battle against beetle grubs, which were plaguing the regions cash crop, sugar cane. (Sugar cane, too, is an import; it is native to New Guinea.) From the Caribbean, the toads were shipped to Hawaii. In 1935, a hundred and two toads were loaded onto a steamer in Honolulu, headed for Australia. A hundred and one survived the journey and ended up at a research station in sugar-cane country, in northeast Queensland. Within a year, theyd produced more than 1.5 million eggs. (A female cane toad can produce up to thirty thousand eggs at a go.) The resulting toadlets were intentionally released into the regions rivers and ponds.

Its doubtful that the toads ever did the sugar cane much good. Cane beetles perch too high off the ground for a boulder-size amphibian to reach. This didnt faze the toads. They found plenty else to eat, and continued to produce toadlets by the truckload. From a sliver of the Queensland coast, they pushed north, into the Cape York Peninsula, and south, into New South Wales. Sometime in the nineteen-eighties, they crossed into the Northern Territory. In 2005, they reached a spot known as Middle Point, in the western part of the Territory, not far from the city of Darwin.

Along the way, something curious happened. In the early phase of the invasion, the toads were advancing at the rate of about six miles a year. A few decades later, they were moving at the pace of twelve miles a year. By the time they hit Middle Point, theyd sped up to thirty miles a year. When researchers measured the individuals at the invasion front, they found out why. The toads had significantly longer legs than the toads back in Queensland, and this trait was heritable. The Northern Territory News played the story on its front page, under the headline SUPER TOAD. Accompanying the article was a doctored photo of a cane toad wearing a cape. It has invaded the Territory and now the hated cane toad is evolving, the newspaper gasped. Contra Darwin, it seemed, evolution could be observed in real time.

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Programmable genetics gets more cash as Tessera Therapeutics gets a $230 million infusion – TechCrunch

Posted: at 4:17 pm

Technologists are getting better at coding biology and venture firms are flooding a new generation of startups with cash so they can commercialize their technology bringing in the next wave of genetic innovation.

Tessera Therapeutics, the Boston-based spin-up from Flagship Pioneering, is the latest company to enter the mix with $230 million in new financing to build up its platform for better biological programming.

The round was led by Alaska Permanent Fund Corp., Altitude Life Science Ventures and the second SoftBank Vision Fund, with participation from the Qatari Investment Authority and other undisclosed investors.

Last year, the company took the covers off its gene-writing service, which combined an array of different gene editing, manufacturing and synthesizing technologies to provide more tailored therapeutic instructions to genetic code.

By providing more instructions to genetic material, the company aims to increase the precision of therapies while expanding the number of potential pathogens or mutations they can target, the company said in a statement.

The thesis is similar to the approach taken by companies like Senti Bio, another early-stage biotech company that raised $105 million earlier this month.

The ability to write in the code of life will be a defining technology of this century and drive a fundamental change in medicine. Todays support is a testament to Tesseras outstanding team of scientists and our focus on bringing the extraordinary promise of Gene Writing to patients, said Geoffrey von Maltzahn, CEO and co-founder of Tessera Therapeutics, and a partner at Flagship Pioneering. We look forward to turning this powerful technology into a new category of medicines.

Part of a number of companies focused on gene therapies and gene-editing technologies that have been developed under the Flagship Pioneering umbrella, Tessera Therapeutics focuses on the development of new therapies that will use messenger RNA, targeted fusogenic vectors and epigenetic controllers, according to Flagship Pioneering founder and chief executive Noubar Afeyan, who also serves as the chair and co-founder of Tessera.

While Senti Bio is adding more programming to existing genetic material, Tessera uses mobile genetic elements, the most abundant genetic material in the body to create new vectors for writing and rewriting the human genome.

The company asserts that this represents a breakthrough in genetic engineering, which can build better therapies. Thats because the technology can target very specific sites in the genome to make any substitutions, insertions or deletions in genetic code. Tessera also said that its tech allows for more efficient engineering of somatic cell genomes without double stranded-breaks and with very little reliance on DNA repair pathways.

Gene writing is inspired by and builds upon the shoulders of natures most prevalent class of genes: mobile genetic elements. Tesseras computational and high-throughput laboratory platform has enabled the team to design, build and test thousands of engineered and synthetic mobile genetic elements for writing and rewriting the human genome.

The company said it can also write entirely new sequences into the genome by delivering only RNA.

With the new round of funding, Tessera said it would look to further develop its tech, hire more staff and establish manufacturing and automation capabilities critical for its platform and programs.

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Juggernaut Just Discovered the New Weapon X | Screen Rant – Screen Rant

Posted: at 4:16 pm

Juggernaut and D-Cel learn the secret, for-profit superhuman prison called the Dungeon is essentially becoming the latest Weapon X program.

Warning! Spoilers to Juggernaut #5ahead!

The Juggernaut and his mutant sidekick D-Cel thought they were going to take down a secret, for-profit superhuman prison called the Dungeon but what they discovered was actually worse. While the original facility was a decoy, the real Dungeon is an airborne prison full of genetically modified guards who are protected by the government to experiment on their seemingly permanent residents in the pursuit of using their powers to better the world struggling to survive everyday superhuman conflict. In essence, the Dungeon is becoming the latest Weapon X program.

The Weapon X program was a clandestine government project that sought to create superhumans that could be used for military purposes. Weapon X was the tenth attempt of the Weapon Plus program which attempted to recreate the success of Project: Rebirth but by using genetic engineering to create mutations within normal humans or manipulate pre-existing mutations within mutants. Weapon X is famously known for capturing Logan Howlett and grafting adamantium to his skeleton, implanting false memories in hopes of molding him into the perfect military operative. Although Wolverine killed many when he originally escaped, the Weapon X program or similar programs have resurfaced occasionally throughout the years, trying but inevitably failing to create the perfect soldier or an army of loyal superhumans.

RELATED:Weapon X Kept Wolverine Prisoner In The Most Humiliating Way

In Juggernaut #5 by Fabian Nicieza and Ron Garney, Juggernaut and D-Cel hit the Dungeon hard but discover the facility is empty, a decoy with a teleporter to the real Dungeon. Although Cain initially has little trouble with the guards, the Dungeon's Warden explains that the guards have been spliced with DNA taken from their residents as he exhibits enough control to temporarily stop Juggernaut in his tracks. Although the guards fail to strip Cain of his powers, they learn that the flying superhuman prison is not only contracted by the USA Justice Department but they've been experimenting on their prisoners, hoping to understand and control certain abilities so they can be properly weaponized.

The guard's experimenting on the prisoners, giving themselves new superpowers, and being protected by the government are all similar behavior that sounds within Weapon X's wheelhouse but what really confirmed the Dungeon's direction was something their warden said. After Juggernaut and D-Cel declare her mutant status and desire to seek political asylum on Krakoa, the Warden is bound by law to let them go but states that the Dungeon is a symbol that the corporate and political world are done with mutants, superhumans, and all the trouble they bring.

Weapon X followed in Project: Rebirth's footsteps but didn't want an army of Super Soldiers to help win a World War but instead desired brainwashed covert super-assassins to handle black ops missions and other secret directives. The Dungeon is not just keeping powerful metahuman criminals incarcerated, it wants to control and manipulate superhumans similar to the villain Syndrome in Disney's The Incredibles. By giving everyone impressive abilities via technology, Syndrome would negate the need for superheroes but the Dungeon is prepared to take that one step further, they seek to manipulate superhumans to destroy other superhumans instead of putting ordinary civilians at risk.

Supercharged and feeling protected, the Warden indirectly challenges Juggernaut by stating that people like him cannot stop what they are doing. No stranger to being manipulated by others, Juggernaut meets with his previous opponents such as Arnim Zola, his android Primus, and the reassembled Quicksand and proposes that they join forces against their common enemy, someone who seeks to abuse people like them for their own purposes. Weapon X's problem was they often tried to control people or forces beyond their capabilities which often ended in death and destruction. By putting themselves in Juggernaut's peripheral, the Dungeon may have set themselves down a similar fate, if they're not careful.

NEXT:Juggernaut Is Forming His Own Team of Reformed Supervillains

The Dark X-Men Just Discovered the Easiest Way to Beat a Villain

Drew is a reader, writer, artist, and creative professional based in Westchester, New York. He dabbles into cosplay, movie references, comics, and some anime while also being a Ghostbuster. He has a Bachelors in History, a Masters in Publishing and is excited to be working with Screen Rant. Previously his articles have been featured on Comic Book Resources and Iron Age Comics and he's excited to see what happens next!

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Last Call with Jenna Balestrini, the WPI grad treating cancer with cell therapy – Worcester Mag

Posted: at 4:16 pm

Sarah Connell Sanders| Correspondent

Jenna Balestrini is the Head of Strategy and Business Development for Precision Medicine and Cell Bioprocessing at Draper.

What is your connection to the city of Worcester?

Well, I love Worcester. I moved there to do my Ph.D. in 2003. I graduated with a Ph.D. from WPI in 2009. I have to say, those were six of the best years of my life. Worcester is such an amazing place and WPI is such a great school. I've always had a fondness for that city more than pretty much anywhere else I've lived. It's just a very special place filled with really great people.

I was hoping you could talk a bit about your career trajectory, particularly after you finished your Ph.D.

I went to WPI and worked for Kristen Billiar, who is the best advisor anyone could ever ask for. One of our focuses was to understand the environment in cells and around cells. Factors like breathing or stiffness can either stimulate cells or impact cells pathologically and create disease. Or, if you understand a cells environment, you can harness those signals and start to build therapies. You can get cells to make specific proteins and we looked at the fundamentals of that. From there, I did a postdoc in Toronto studying fibrosis with Boris Hinz. Then, I went to Yale and worked for Laura Niklason doing translational medicine work. All of this ties to understanding how we can direct regenerative medicine applications with cells by understanding the cues around them to make different therapies. In 2016, I was at the end of my postdoc and I was trying to think about what to do. I had wanted to be a professor for many years, but towards the end, I realized what I really wanted was to be more translational and be a little bit closer to where the patients and the action are. I had a friend that I met at WPI who recommended I speak to her uncle, Jeff Borenstein, at Draper. I'd never heard of Draper before and I didn't know much about the nonprofit world. He looked at my CV and said, "You know what, you'd actually make a really good fit here."

What can you tell me about Draper?

I came to Draper in 2016. As a nonprofit, Draper reinvests its profits into research. One of the manifestations of that are large internal awards called IRaD, which stands for Internal Research and Development. Within six months, I got an IRaD to build technologies to make the next generation of cell therapy. That project went from concept to commercial pretty quickly. I transitioned into being a business development lead and then the portfolio grew even more, mainly because I work with some really talented engineers, some of whom went to WPI. Ultimately, we partnered with Kite Therapeutics. So what that means is my career in cell therapy literally went from an idea scribbled on a napkin with a colleague, to overseeing a partnership with, in my opinion, one of the best cell therapy companies in the world in just a few years. I am in a completely different space than I ever would have imagined. I had no idea I'd ever go into business or cell therapy and I'm really pleased.

I suspect a lot of great ideas have started on napkins. I'm curious about just the term cell bioprocessing. Can you explain it for someone lacking a science background?

Basically, what we're trying to do is take cells from a patient and modify them to make those cells into therapies themselves. It's a really interesting way to enable a patient to heal themselves. We take your immune system cells and then we genetically modify them with equipment that we've made. The equipment separates the cells from your blood, and then we introduce genes that serve as a set of instructions for your immune system to attack something like cancer. Think of it like taking those cells from the patient, giving them some extra tools to make them "super-powered," to make them better at hunting down and identifying things like cancer, and then putting them back into the patient.

Sounds very futuristic.

So here's the thing, I don't know why this is, but most people don't realize that it's not 10 years from now. It's happening right now. Cell therapy is FDA approved. If you have certain types of leukemia or lymphoma, you can get cell therapy made from your cells to target and kill your cancer. And this is a curative solution. You can get a dose of these cells that have been modified to hunt the leukemia down, or lymphoma down, and then you are cured from that disease.

That's amazing.

We're living in an era where cancer is curable. But now, the thing is, can we take it further? You can identify a unique combination that separates out the thing you're trying to hunt down HIV, hepatitis. You can also use the same tools to rectify genetic diseases like sickle cell anemia or cystic fibrosis. It's just a faulty gene that you can replace, right? Those are the next steps.

What are your hopes for the future?

You know what? I would like people to get excited. Everything I just described is what's called autologous cell therapy we take cells from a patient and do all of this work and it's really expensive to do but the future is something called allogeneic cell therapy, where we can take the same tool to do genetic engineering or modification of cells and knock out all those individual components that make yourself uniquely identifiable to you. From that, you create a universal donor. And you can use that as a starting material to make therapies for everyone. So what that means for you as a patient is that you could come into your doctor's office and find out you have something, let's just say a cancer, and you'll have an off-the-shelf ready-to-go therapy that day, frozen and ready to go for you. I don't think that chemotherapy and radiation are going to last much longer in terms of what the first line of defense is going to be. And they're terrible. The truth is, we are still behind the times with cancer therapy. If you look at the cause of death over the last hundred years, pretty much everything but cancer has gone down. Heart disease, influenza, strokes, but not cancer. This is for a variety of reasons, one of which is that we're living longer. But the thing is, our tools are terrible. We kill people with our drugs. Weve arrived at a moment when we can finally imagine a world where cancer is no big deal.

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