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Category Archives: Transhuman News

There Is No Sex and the City Without Samantha – Rolling Stone

Posted: January 13, 2021 at 4:49 pm

There are many reasons And Just Like That,the forthcoming HBO Max reboot ofSex and the City, is a terrible idea. Theres the fact that the most recent installment of the franchise, Sex and the City 2, was released more than a decade ago, roughly the same time as the Eyjojakfull volcano, or eons ago in internet years. Theres the fact that Sex and the City 2was critically reviled due to its bloated two-and-a-half-hour run time, inherent Islamophobia, and clunky screenplay featuring such sterling wordplay as Lawrence of my labia. And theres the fact that, while critically acclaimed and hailed as subversive at the time of its release, Sex and the Cityitself has aged rather poorly, presenting a fantasia of New York City in which everyone is white, thin, heterosexual, and prone to wearing oddly positioned belts.

But the primary reason the Sex and the Cityreboot is a bad idea is the glaring absence of one of its four main characters the one who constituted the heart and soul, and arguably the moral center, of the entire franchise: the sexually voracious publicist Samantha Jones, played by Kim Cattrall.

Cattrall has been publicly warring with the other main players in the Sex and the Citycast in case you just woke up from a coma: Sarah Jessica Parker as navel-gazing writer Carrie Bradshaw; Cynthia Nixon as uptight attorney Miranda Hobbes; and Kristin Davis as WASPy gallerist Charlotte York for years, accusing them of forming a mean-girl clique that excluded her at every turn. (Naturally, at one point there was a dispute over being invited to a rental property while shooting in the Hamptons.) She repeatedly told interviewers that she would not participate in another installment of the franchise. Whether or not you think her stance is justified depends on numerous factors, like whether you tend to align yourself with the underdog (in this case, Cattrall) or youre a fan of celebrity-branded $400 shoes (SJP). Regardless, anyone actively rooting for a SATCreboot knew in their hearts that it would be one without Samantha, which last weeks release of the And Just Like Thatteaser confirmed.

But aSex and the Cityreboot without Samantha is noSex and the Cityat all. Its a paltry cash-grab, a facsimile of its former self, a screen grab of a Xerox copy of the very elements that have engendered such a rabidly loyal fan base to this day. Because as even the biggest SATCcritics know, at its core Sex and the Cityis neither about sex nor the city, nor shoes nor Chris Noths cleft chin, nor inexplicably wearing belts around your midriff its about the enduring power of female friendship. And the absence of one of the core group of female friends at its heart betrays that very idea.

In a different world, on a different series, and with a different actor, Samantha would have failed to rise above a mere caricature. She is libidinous to a comical degree, with a level of horniness rarely seen outside a MILF porn or tweets about Jon Ossoff. She has a propensity for snappy, Mae West-esque one-liners (dirty martini, dirty bastard, she purrs as she splashes a drink on a loutish ex-lover) and a level of confidence that seems borderline chemically induced, a fortysomething version of a homophobes conception of a drag queen. Indeed, more than one person has referred to the character as effectively a gay man in drag, though that perspective says a lot more about a persons views of gay male sexuality than it does about Cattralls portrayal.

But despite the cartoonishness of the character, and some of the politically incorrect lapses for which the show has been retroactively flagellated (see: the one time Samantha dated a man of color, referring to his big black cock), Samantha also has a bounty of admirable qualities. She is unapologetic about her lifestyle, continuously rebuffing judgmental health care professionals and snooty society wives. In the face of adversity, she is indefatigable, as seen in the final season when, struggling with breast cancer, she delivers a frank, vulgar speech at a cancer benefit, culminating in all the attendees proudly tossing their wigs into the air. Above all else, she is fiercely loyal to her friends, taking their sides even in petty skirmishes. At a baby shower, when Charlotte accuses a pregnant woman of stealing her future baby name, Samantha doesnt hesitate in calling the pregnant woman a bitch and ushering Charlotte out of the party; when a fragile Carrie tells her she is having an affair with her shitty ex, Samantha is unflappable, coolly telling Carrie that judging her for such a transgression is not [her] style. Critics have accused the four women at the heart of Sex and the City of being pathologically shallow and self-involved, but that applies the least to Samantha. In fact, despite being the most hedonistic, vice-indulging member of the quartet, she is arguably the most ethical.

Its hard to overemphasize just how large a role Cattralls performance plays in this. A less deft performer would play Samantha as little more than a man-eating cougar, Mrs. Robinson meets Jessica Rabbit with a dash of RuPaul thrown in for good measure. But while Cattralls campy delivery of punny lines like, Youre dating Mr. Big, Im dating Mr. Too Big is not beyond parody (and Christina Aguilera did so to pitch-perfect effect on an old episode of Saturday Night Live), she consistently imbues it with a level of fragility that goes above and beyond the material the writers gave her. Theres no better example of this than when she is betrayed by Richard (James Remar), the loutish hotelier who is the only man to truly scale Samanthas steely exterior. After she walks in on him giving oral sex to a random woman, she smashes a painting of a heart over her knee. There. Now your hearts broken too, she sobs. In the hands of a lesser actor, the line would be laughable. But Cattrall delivers it with such exquisite sorrow and conviction that its hard not to have your heart break along with hers.

Critics are not shy about pointing outSex and the Citys multifarious flaws, its attitudes toward race and sexuality among them (remember when Samantha becomes a lesbian?), as well as its healthy doses of Catskill comic-level puns. Few have singled out Cattralls virtuoso performance, how nimbly she fills out what should have been a wolfish caricature with warmth and vigor which is even more impressive considering how miserable Cattrall says she was during the duration of the series. (She claims she was subject to the worst treatment of all by Parker; the fact that Parker publicly has been nothing but kind and infuriatingly gracious in response makes Cattrall look terribly petty and makes me believe she is telling the truth.) People often single out Nixons understated, Emmy-winning performance as an example of real acting on the series, but nothing will ever make me laugh or make my heart soar more than Samantha triumphantly defending her life choices to Carrie by proclaiming she will blow whoever she wants as long as she can breathe or kneel.

Theres been much discussion over how theSATCreboot will deal with Samanthas absence. Cattrall has said she would like to see the character recast, perhaps with a woman of color or a nonbinary person, a laudable goal if not one that glosses over the privileged, white femaleness of the character. Meanwhile, Parker has responded to fans objections by primly saying: Samantha isnt part of this story. But she will always be part of us. No matter where we are or what we do. This leads me to believe that the writers have probably killed her off, perhaps by the breast cancer that she so valiantly fought in the shows final season. This strikes me as both a betrayal of the character and of Cattrall herself. All of the main characters on the show are fantasy versions of women, and fantasies by definition do not die, especially one with as much vibrancy as Cattrall gave Samantha. To casually murder the woman she spent nearly two decades embodying at great personal cost, according to her seems like nothing short of a slap in the face. But above all else, SATCwithout a Samantha is an insult to the fans who have spent 20 years falling in love with the world the show has built and the women who live in it and they should accept nothing less than the complete version of the real thing.

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After 27 years, the Indian Charlie newsletter is out of business – Horse Racing Nation

Posted: at 4:49 pm

Itwas always irreverent, often controversial and fiercely independent. As of thisweek, Indian Charlie is no more.

Thesardonic newsletter that Ed Musselman distributed free of charge for nearly 27years, first on racetrack backstretches in Kentucky and more recently throughdigital media, was posted for the last time Monday, according to its leadstory. (See the final issue here.)

Notbeing able to interact directly with horsemen and women at both racetracks andat horse sales due to the coronavirus took away any advantage we had to reporton issues and stories not otherwise covered in mainstream Thoroughbred racingpublications, the story said.

Withoutgetting into specifics, the note to readers mentioned some mistakes wemade last year that also entered into this decision, that Indian Charliewas a bit of a rerun in 2020 and that, in some ways, the game has passed usby.

Musselmanturned down a request from HRN for an interview Monday.

Inits familiar legal-sized format, but without the usual back page full ofadvertisements, Mondays edition was the first in two months, although aThanksgiving-to-New Years Day break has been the norm for years.

Withits slogan we never let the truth get in the way of a good story, IndianCharlie was equal parts TMZ and The Onion. Its biting, anti-establishmentattitude made it popular with many backside denizens. But it also was polarizing.

Itsstaunchest supporters praised its no-boundaries, take-no-prisoners style, whileits loudest critics said Indian Charlie was too often racist and sexist.Churchill Downs, Keeneland and racetracks run by the New York RacingAssociation and The Stronach Group took turns banning it when their executives believedits content was too politically incorrect.

Aflashpoint came in 2014, when Louisville Metro police were called to investigatethe report of a fistfight at Churchill Downs between Musselman and one of thenewsletters frequent targets, trainer Dale Romans. Yes, it was over somethingthat Muggins wrote.

IndianCharliewent down swinging Monday, saying the new Horseracing Integrity and Safety Act bringshope that it will be the answer (to) suspect governing bodies like theKentucky Horse Racing Commission and the New York State Racing and WageringBoard calling balls and strikes in our sport.

Thelast of its trademark caricatures, always with an accurately depicted face,lampooned horse owner Don Gamble, perhaps making him the answer to a triviaquestion about the history of Indian Charlie.

Therewas also a serious editorial calling into question the absence of trainers DavidWhiteley, Richard Hazleton and Dickie Small; jockeys Larry Snyder and JohnLively; and horses Nodouble and Broad Brush from the National Racing Museum andHall of Fame.

TheLast Word took a swipe at animal-rights activists while being 100 percent allin for the federal intervention and tightening of all approved medications exceptLasix.

Musselmandid not go into detail about plans for his future. Instead, it was left tothe newsletter to say whatever direction we go in, any new pursuits going forward,will be announced first on this website.

IndianCharliearchives will remain available at IndianCharlie.com.

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No magazine cover should have 1 woman and 9 men – Pitch

Posted: at 4:49 pm

latest-stories

Guest Column: But then again, writes Mithila Saraf, Business Head, Famous Innovations, no industry should have such few women leaders

Advertising is overwhelmingly, unapologetically, unabashedly a boys club. All-male panels, all-male juries, all-male boardrooms werent unheard of until recently when having all-male anything became politically incorrect. You can count the number of women CCOs in our country on one hand (and you wouldnt even need the whole hand). The situation is no less grim at the bottom, take a look at any creative team in any agency. So much so that I have seen even the few creative women who are at the top, often turn themselves into pseudo-guys, laughing, joking and spitting like men (metaphorically, of course) to fit into this gang. Its no surprise then, that when a publication starts hunting for the people behind some of the years best work, they run into a wall full of men.

So yes, lets get mad at IMPACT, but lets also realize that this cover is a symptom of the issue and not the issue itself. The covers will change when our creative leadership and creative teams change. Otherwise, wed only be fixing advertisings PR problem, not its diversity problem. Otherwise, wed only be signaling to journalists that the next time you have a cover like this, go far and beyond to find women to put on the cover. This will then worsen the oft-repeated narrative, shes only there because shes a woman or shes only there for the diversity count. The point is, they shouldnt have to look far and beyond. And they wont. If all of us decide to look a little harder in our everyday hiring, nurturing and promoting decisions.

The secondary cause for concern here is also whose idea makes it to covers like these. Barring a few, you will mostly see Agency Heads on this cover. Do only Agency Heads at these agencies come up with ideas that make headlines? Do younger people in their teams not come up with good ideas? And if so, what are they doing in that agency? No, its just that it is the senior-most people whose ideas finally go through and see the light of day. Talk to any creative at any network agency and you will hear this story every day. At a time when advertising is already losing its sheen, this tells younger people, youre better off in content or just freelancing. This makes things worse for the representation of women because the number of women at the top is scanty anyway.

So what can be done about all of this? Start by looking around the floor at your team. Go back and review the last few multi-crore films you released. Do you see enough young people and women represented there? Its easy to say, we dont get talent / good ideas from these groups. Its harder to ensure that you sit down with them, help them with their ideas and give them the time they need to do what you could do in a matter of minutes in your sleep. Further, when you are invited to a jury, a panel or a cover, ask what is the ratio of men to women there. And the next time you hear a colleague or a friend undermine the success of a woman (even jokingly), remember that she was 9 times less likely to make it up there.

Disclaimer: The views expressed here are solely those of the author and do not in any way represent the views of pitchonnet.com.

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Hamilton savaged by Spitting Image on his birthday – Grand Prix 247

Posted: at 4:49 pm

Spitting Image, the legendary political satire starring puppets, have savaged recently knighted Sir Lewis Hamilton in a tongue-in-cheek skit released on the occasion of his 36th birthday last week.

In Lewis Hamilton, Crusader For Justice he is depicted driving a car and justifying his stance on the environment, racing in politically incorrect countries and basically taking the mickey of the causes close to his heart, while wickedly suggesting double-standards by the seven-times F1 World Champion.

In an unprecedented year for the planet, Lewis has become a crusader for human rights and injustice around the globe. He instigated taking a knee by F1 drivers during the national anthem before a Grand Prix.

#BlackLivesMatter issues are close to his heart and the Briton galvanised awareness of the movement through his symbolic gestures and high-profile comments.

Mercedes went as far as changing the Silver Arrows livery to black.

The legendary, hold no punches, Spitting Image satire TV series is back since last year after a hiatus stretching from 1996, and are now back exclusively on BritBox. More information here>>>

More than 100 puppets have been crafted for the new series with the original shows co-creator Roger Law back to head the creative team with some of the worlds biggest names in his sights, Sir Lewis has not been spared..

f1formula 1formula oneLewis Hamiltonseasonspitting imagesworld championship

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The worlds we build and destroy with words – The Times of Israel

Posted: at 4:49 pm

Words have long been humanitys most useful tool.

Few have described this more eloquently than Rabbi Jonathan Sacks ztl, the former Chief Rabbi of the UK, who passed away last year:

With words God created the universe: And God said, Let there beand there was. Through words He communicated with humankind. In Judaism, language itself is holy God created the natural universe with words.

God, in the narrative of Genesis, could have chosen any medium with which to create the world. He could have used a paintbrush to create life forms, or He could have merely thought the world into existence. Instead, he chose speech. He did this to convey a message that is no less significant today as it was in the days of old. In Sacks words:

We create worlds with words.

To put it in scientific terms: Yuval Noah Harari, the acclaimed Israeli author of the New York Times bestseller Sapiens: A Brief History of Humankind,argues that the distinguishing characteristic of Homo sapiens is its unique ability to create complex systems of communication. Other species can communicate, but only on a basic level. But the human affinity for creating complex languages has allowed us to communicate beliefs, value systems, and/or myths to others that eventually result in mass cooperation cooperation on a scale that no other species has been able to achieve. Language has allowed humans to develop rich cultures and thriving civilizations. Hararis anthropological message is the same as Rabbi Sacks religious one: worlds emerge from words.

Anything that can be used for good can also be used for bad, and words are no exception. While words can bring rights for minorities, they can also lead to their subjugation at the hands of the majority. While words can bring freedom, they can also bring tyranny. While words can make society progress, they can also make it regress. While words can build worlds, they also have the power to destroy them.

Alternatively, to paraphrase Joe Biden: while words can inspire, they can also incite. Irrespective of ones views of the President-elect, that is an unavoidable truth.

We saw the power of words on display last week at the US Capitol insurrection. Instead of being used to build and inspire, words were used to destroy and incite.

Thousands of people, present because of the disproven falsehoods that were fed to them about the election in an effort to stop the steal, attended a Trump-organized rally in Washington D.C. on the day Congress was to conclusively certify Joe Biden as the winner of the election. But this was no mere demonstration. Trump urged his supporters to fight much harder against bad people; affirmed that his followers can never take back our country with weakness, [that they] have to show strength and [they] have to be strong; and told them that when [they] catch somebody in a fraud, [they] are allowed to go by very different rules. He invited them to march over to the Capitol. If you dont fight like hell, he asserted, youre not going to have a country anymore, also proclaiming, We will never give up. We will never concede.

The speech he delivered was deeply terrifying. Ultimately, whether it was from his speech that day or the lies he had been spewing beforehand, the destruction we saw was brought about as a result of words.

Throughout the past four years, many people have dismissed much of Trumps problematic use of words. Hes Trump, some would say. Hes rough around the edges; hes politically incorrect. Sometimes he phrases things wrongly. He isnt a conventional politician, and thats precisely why people like him. Dont overreact to mere words. But what people, among whom I include myself, didnt fully understand was the full powerof those words. The power they had to foment a political climate of falsehood, conspiracy theories, and extremism. The power they had to bring people to storm the US Capitol with QAnon, neo-Nazi, and white supremacist symbols. The power they had to result in the first siege of the US Capitol since the War of 1812.

Embed from Getty Images

Whenever a significant event happens, we should always think about what we can learn from it and how we can apply what we learn to our personal lives. Here is the simple message I think we should internalize after last weeks events: words matter. The way we speak matters. Problematic rhetoric should not be dismissed as just words, or just political incorrectness. There is a direct correlation between dangerous words and violent action. We arent the President, and we dont have such a wide-ranging audience as he does. But words are powerful even coming from regular people, people like you and me. While we dont have presidential powers, we do have another type of power, one constantly used in everyday life. It is a power that can be used for societys betterment if used to bring people together, but one that can also lead to societys destruction if used to tear people apart. Such is the power of words. The choice of how we use this power is solely up to us.

The way we talk indicates who we are. The words we choose demonstrate who we choose to be. Let us all internalize the timeless message that can be learned from last weeks horrific events, that while words can build worlds, they can, if not chosen carefully, be used to destroy them.

Lets use them to build.

Zev Bell is a Jewish 17 year-old student who attends TanenbaumCHAT high school in Toronto. He has a particular interest in politics, Judaism, philosophy, and science.

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Attack on the Capitol and the German far right – Cleveland American

Posted: at 4:49 pm

The violent entry of protesters into the Capitol provoked a wide range of views in Germany. In the context of analyzes, some historical analogies have been used and similar incidents have been mentioned in recent years.

a Radio interviewFor example, the historian Achats von Mller drew parallel attention between the Washington attack and the so-called March on Rome organized in October 1922 by the Italian fascist leader Benito Mussolini.

Many German politicians recalled the events of August 29, 2020 in Berlin. In a demonstration against coronary measures, a group of German ultranationalists tried to force their way into the Bundestag building in Berlin.

The most common of those who tried to enter the building were the so-called Reichsburgers (Reichs citizens). (More details about Reichsberger here.)

Most far-right groups in Germany called the Washington attack a patriotic operation. This is despite the traditional anti-American characteristic of most nationalist organizations created in the post-war period.

In October 2014, this trend became apparent to the founders of the anti-Muslim and racist movement Pekida (abbreviated as European Patriots Against Islamization of the West). The founders initially wanted to call it: Pegota, European Patriots Against Western Americanization (recalls Volker Weiss in 2017: Dictatorial Rebellion. New ownership and the fall of the West.)

Groups and individuals not recommended by Methane openly expressed their sympathy and solidarity with those who entered the Capitol. Their position on the United States changed after Donald Trump became president. The origins of the Q-Anan conspiracy movement and the intensification caused by coronary restrictions have contributed to the strange international repercussions of unity.

The publications of German extremist activists or those close to sophisticated organizations were firmly aligned with the American rebels.

Here are some notable examples from radical, ultra-conservative and German nationalist publications.

The American election is the biggest fraud not only in American history but also in the history of democracies

Stage PI , (Politically incorrect), states that what has happened in the United States since 10.1.2021 is nothing more than an attempt to intimidate, punish, and isolate nearly 80 million Americans. -They voted for Trump. Of course, this election points to an unproven study that is the greatest fraud not only in the history of the United States, but in the history of democracies. (The study was published by a Romanian-language publication of the same name. On January 6, the Romanian extremist publication published an article entitled Patriots Occupy Capital Building! War to Save America.)

Death of the Patriot Ashley BabbittGerman courier(8.1 to 21) says he fell in the struggle for his firm belief that Donald Trump won the presidential election.

The right-wing racist and extremist party Third Way (Der III. Weck) claims that Ashley Babbitts death was a conscious assassination by an African-American police officer.

Editor of the Ultranationalist, Anti-Racist and Anti-Muslim Journal Small shop(7.1 to 2021), Jrgen Elsaser likens the attack to a revolution for the salvation of democracy. In his article, he argues that the established media is a liar and that the action of the rebels is a peaceful and patriotic act. These psychic forces are the result of the infiltration of psychic forces into the conservative and national-patriotic parties, which Elseir argues for in his rhetoric and anti-democratic attitudes (according to activists and activists on the Internet and social media), are now on the verge of establishing a global crown-dictatorship.

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Here’s what we know sex with Neanderthals was like – BBC News

Posted: at 4:37 pm

Their eyes met across the rugged mountain landscape of prehistoric Romania.

He was a Neanderthal, and stark naked apart from a fur cape. He had good posture and pale skin, perhaps reddened slightly with sunburn. Around one of his thick, muscular biceps he wore bracelet of eagle-talons. She was an early modern human, clad in an animal-skin coat with a wolf-fur trim. She had dark skin, long legs, and her hair was worn in braids.

He cleared his throat, looked her up and down, and in an absurdly high-pitched, nasal voice deployed his best chat-up line. She stared back blankly. Luckily for him, they didnt speak the same language. They had an awkward laugh and, well, we can all guess what happened next.

Of course, it could have been far less like a scene from a steamy romance novel. Perhaps the woman was actually the Neanderthal and the man belonged to our own species. Maybe their relationship was of the casual, pragmatic kind, because there just werent many people around at the time. Its even been suggested, too, that such hook-ups werent consensual.

While we will never know what really happened in this encounter or others like it what we can be sure of is that such a couple did get together. Around 37,000-42,000 years later, in February 2002, two explorers made an extraordinary discovery in an underground cave system in the southwestern Carpathian mountains, near the Romanian town of Anina.

Even getting there was no easy task. First they waded neck-deep in an underground river for 200m (656ft). Then came a scuba dive for 30m (98ft) along an underwater passage, followed by a 300-metre (984ft) ascent up to the poarta, or mouse hole an opening through which they entered a previously unknown chamber.

Inside the Petera cu Oase, or "Cave with Bones", they found thousands of mammalian bones. Over its long history, its thought to have primarily been inhabited by male cave bears extinct relatives of the brown bear to which they largely belong. Resting on the surface among them was a human jawbone, which radiocarbon dating revealed to be from one of the oldest known early modern humans in Europe.

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Gaucher Disease Treatment Market Shows Expected Trend to Guide from 2020-2026 with Growth Analysis | Genzyme Corporation, Pfizer, Inc., Shire Human…

Posted: at 4:37 pm

This Global Gaucher Disease Treatment Market report has been formulated by considering an ever-increasing demand and the value of market research for the success of different business sectors. This market report comprises many work areas of the Healthcare industry. It is not only professional but also is comprehensive which focuses on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis.

The size of the global Gaucher Disease Treatment Market is expected to grow in the forecast period from 2020 to 2027, with a CAGR of XX. x% over the forecast period from 2020 to 2027 and is expected to reach XXX. X million by 2027, starting at XXX. X million in 2019.

Gaucher disease is an autosomal recessive inherited metabolism disorder where a type of fat (lipid) called glucocerebroside is unable to degrade. Body synthesis enzyme called glucocerebrosidase, which breakdowns and reprocesses glucocerebroside. Gaucher disease is caused by mutations of a single gene called GBA, which leads to very low levels of glucocerebrosidase enzyme leading to low degradation of glucocerebroside. There are three types of Gaucher disease namely: type 1, type 2, and type 3. Type 1 is the most common type of Gaucher disease while Type 2 and 3 are not as common as type 1.

Global Gaucher Disease Treatment Market competition by Top Key Players: Genzyme Corporation, Pfizer, Inc., Shire Human Genetics Therapies, Inc., and Actelion Pharmaceuticals Ltd. (acquired by Johnson & Johnson in June 2017). There are various drugs in pipeline of companies such as Lixte Biotechnology Holdings Inc, JCR Pharmaceuticals Co Ltd, Pharming Group NV and Orphazyme ApS, for Gaucher disease treatment.

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Analysis Of The Competitive Landscape:

The competitive landscape is an essential aspect that all key players must know. The report highlights the competitive scenario of the Gaucher Disease Treatment global market for competing nationally and globally. Market experts also presented an overview of all major players in the global Gaucher Disease Treatment market, taking into account key aspects such as the areas of operation, production and the product portfolio. In addition, the companies in the report are studied based on key factors such as company size, market share, market growth, revenues, production volume and profits.

Market Scope

The Global Gaucher Disease Treatment Market Analysis to 2027 is a specialized and in-depth study of theHealthcare industry with a special focus on the global market trend analysis. The report aims to provide an overview of the Gaucher Disease Treatment market with detailed market segmentation by component, product, application, and geography. The global Gaucher Disease Treatment market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading Gaucher Disease Treatment market players and offers key trends and opportunities in the market.

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Promising Regions & Countries Mentioned In The Gaucher Disease Treatment Market Report:

Table of Content (TOC):

Chapter 1 Introduction and Overview

Chapter 2 Industry Cost Structure and Economic Impact

Chapter 3 Rising Trends and New Technologies with Major key players

Chapter 4 Global Gaucher Disease Treatment Market Analysis, Trends, Growth Factor

Chapter 5 Gaucher Disease Treatment Market Application and Business with Potential Analysis

Chapter 6 Global Gaucher Disease Treatment Market Segment, Type, Application

Chapter 7 Global Gaucher Disease Treatment Market Analysis (by Application, Type, End-User)

Chapter 8 Major Key Vendors Analysis of Gaucher Disease Treatment Market

Chapter 9 Development Trend of Analysis

Chapter 10 Conclusion

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Competitive companies and manufacturers in the global marketBy Product Type, Applications & Growth FactorsIndustry Status and Outlook for Major Applications / End Users / Usage Area

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Best from science journals: Why are platypus so weird? – The Hindu

Posted: at 4:37 pm

Here are some of the most interesting research papers to have appeared in top science journals last week.

(Subscribe to Science For All, our weekly newsletter, where we aim to take the jargon out of science and put the fun in. Click here.)

Published in Nature

Australias duck-billed platypus are the perfect example of weird - they lay eggs, nurse their young ones, are toothless with webbed feet, and most interestingly, have 10 sex chromosomes.

Belonging to an ancient group of mammals called monotremes, platypus have always confused scientists. Now, by mapping the complete genome of the mammal, researchers have answered a few questions about the species. The team explains that they are a mixture of mammals, birds and reptiles and have preserved many of their ancestors original features which help in adapting to the environment they live in.

Published in Nature Plants

One particular type of rice plant grown in Zhejiang,China was found to be resistant to the plant pathogen Burkholderia plantarii. But how and why? Researchers who studied the seed of the plant found that a bacteria called Sphingomonas meloni that lived inside the seed helped the plant gain this resistance. The bacteria produce an acid called anthranilic acid which inhibits the pathogen thus saving the crop.

Published in Nature Methods

Minion device. Credit: https://nanoporetech.com/

Weighing just 450gm and measuring 14cm, Oxford Nanopore Technologies MinION device has helped sequence DNA on the go. Now, using special molecular tags, a team from the University of British Columbia has reduced the error rate to less than 0.005%. A beautiful thing about this method is that it is applicable to any gene of interest that can be amplified...it can be very useful in any field where the combination of high-accuracy and long-range genomic information is valuable, such as cancer research, human genetics and microbiome science," writes Ryan Ziels, one of the authors of the study, in a release.

Published in Nature Climate Change

By the late 21st century, the population facing extreme droughts could more than double - from 3% ( from 1976 to 2005) to 8% by 2099. The team notes that this could heighten human migration and conflict. The paper, based on 27 global climate-hydrological model simulations spanning 125 years, also stresses the urgent need for water resources management.

Published in Cell Host & Microbe

Phytoplankton bloom in the Arabian Gulf, Credit: Jeff Schmaltz, MODIS Rapid Response Team, NASA/GSFC.

Researchers have now found that viruses play an important role in microalgae evolution by whole-genome sequencing 107 different species of microalgae from different ecosystems. They compared the genomes of salt-water (marine) and fresh-water microalgae and found that the marine species contained more viral-origin genes. Sequences from Chlorovirus, Coccolithovirus, Pandoravirus, Marseillevirus, Tupanvirus, and other viruses were found integrated into the genomes of algal from marine environments, notes the paper.

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Best from science journals: Why are platypus so weird? - The Hindu

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Developmental Biologist Kathryn Anderson Dies at 68 – The Scientist

Posted: at 4:37 pm

Kathryn Anderson, a developmental biologist at the Memorial Sloan Kettering Cancer Center known for her work detailing the genetics of early embryogenesis, died November 30 at age 68.

Throughout her scientific career, Anderson used rigorous genetic screening assays to identify mutations suspected of disrupting cell division and differentiation in model systems. Having identified a gene of interest, she would then turn to a technique known as forward genetics, creating model organisms such as fruit flies and mice with a particular phenotype to better understand its molecular underpinnings. Using these tools, Anderson made important contributions to scientists understanding of several genetic pathwaysmost notably the Toll and Hedgehog pathwaysrequired for proper development of these animals.

Kathryn was fearless and very open-minded, Tatiana Omelchenko, a senior research scientist in Andersons lab who uses confocal microscopy to do live imaging of mouse embryos, tells The Scientist. Every lab has its own environment and its own mood, and when you stepped into Kathryns lab, you immediately felt very focused.

Born in La Jolla, California, in 1952, Anderson became interested in science at a young age, stemming back to an article in LIFEthat included a detailed image of a human fetus, according to an interview released shortly after her death. She attended the University of California, Berkeley, where she earned her undergraduate degree in biochemistry before heading to a graduate program in neurodevelopment at Stanford University in 1973.

Anderson left that program after only two years, earning a masters degree in neuroscience, and spent the next several years looking for her scientific niche. She enrolled briefly in medical school at the University of California, San Diego, an experience that led her to realize her love of basic research. The clinical work wasnt my cup of tea, Anderson shared in a 2005 biography. The lab was where I felt most at home.

Ultimately, Anderson landed at the University of California, Los Angeles, studying the developmental genetics of Drosophilaunder the guidance of biologist Judith Lengyel. For her PhD work, Anderson showed that in the first two hours after fertilization, the development of Drosophilaembryos remains under maternal control, with maternal RNA and proteins directing cell division and differentiation within the egg.

Looking to further her study of fruit flies, Anderson next traveled to the Max Planck Institute for Developmental Biology in Germany as a postdoc to work with Drosophilageneticist Christiane Nsslein-Volhard. In 1995, Nsslein-Volhard would share a Nobel Prize for her work using mass screenings to identify mutations that disrupt embryonic development, and Anderson would continue studying a handful of the genes identified in these early screens throughout her career.

One such gene, known as Toll, turned out to play an important role in dorsal-ventral (D-V) differentiationdictating, as Anderson said in her biography, how a fly embryo knows its back from its belly. In addition to probing the function of Toll,Anderson continued building out the wider Toll pathway after returning to the University of California, Berkeley, as an assistant professor in 1985, and later in her own lab at the Sloan Kettering Institute, which she launched in 1996 at Memorial Sloan Kettering. During this time, Anderson and her team identified roughly a dozen genes involved in cell differentiation along the D-V axis, and she used similar screening methods to better understand Tolls role in innate immunity of Drosophila. Her findings were noted by geneticists Jules Hoffmann and Bruce Beutler, whose study of Toll-like receptors in both fruit fly and mammalian immunity would later earn them a Nobel Prize.

Kathryn Anderson

Memorial Sloan Kettering Cancer Center

After her successes in fruit flies, Anderson began thinking about applying her same methods to the study of mice. She spent a year on sabbatical in the lab of Rosa Beddington at the National Institute for Medical Research in the UK, where she showed that Toll had no analogous role in the D-V differentiation of mammals. It demonstrated, she said in a 2016 interview with Development, that there are things about early mammalian development that you cant figure out by extrapolating from flies.

Back at the Sloan Kettering Institute, Anderson began once again using mass genetic screenings, this time to identify mutations of interest in mice, and then studying them in fine detail. These were lengthy experiments that often took years to yield results. I think her major contribution is discovering the functions and roles of genes through this mutagenesis screen, Omelchenko says. This is amazing because . . . the mouse embryo model is quite complex, but she did the work.

Anderson and her team screened more than 12,000 mutations, selecting roughly 40 that produce obvious phenotypic disruptions midway through gestation. Working diligently over many years, Anderson identified previously unknown pathways that have since prompted new research directions in the field of developmental biology.

Through her screening, for example, Anderson identified a previously unknown relationship between ciliamicroscopic, hairlike structures on the outside of some cellsand proper signaling of the Hedgehog pathway that dictates cell differentiation in mammalian embryos. Further research showed that components of this pathway are enriched in cilia, while mice with certain mutations in genes involved in Hedgehog signaling lacked cilia altogether in a structure called the node that directs gastrulation in vertebrate embryos. That turned out to be pretty amazing, actually: theres this whole organelle required for Hedgehog signaling in vertebrates, but not in flies, Anderson said in her Developmentinterview. Its a geneticists dream, but raises the question of why organize the genome like this: there are so many weak points in Hedgehog signalingand Hedgehog is so vital.

For her contributions to the field of developmental biology, Anderson was inducted into the National Academy of Sciences in 2002 and elected as a member of the Institute of Medicine of the National Academies in 2008. In addition, she was awarded the Thomas Hunt Morgan Medal for lifetime contributions to the science of genetics in 2012, the Federation of American Societies for Experimental Biologys Excellence in Science Award in 2014, and the Society for Developmental Biologys Edwin G. Conklin Medal for distinguished and sustained research in 2016, among other honors.

Prior to her death, Anderson had spoken about the possible extension of her research into human genetics, as disruptions in hedgehog signaling have since been linked both to birth defects and to a series of diseases referred to as ciliopathies. It was, however, a line of questioning she planned to leave to other scientists, content to continue her methodical work exploring mutations in mice.

Many scientists are very quiet people, but contemporary society requires you to be very loud [so] that people will listen to you, Omelchenko says. Kathryn is such a great example of being quiet, being a very deep thinker, and at the same time becoming a very successful and bright scientist. I think I will keep learning from her even though she has passed away.

Anderson is survived by her husband, Timothy Bestor, a geneticist at Columbia University.

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Developmental Biologist Kathryn Anderson Dies at 68 - The Scientist

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