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Category Archives: Transhuman News

Shop the 5 Best Moisturizers to Combat Dry January Skin – Us Weekly

Posted: January 15, 2021 at 1:56 pm

You may not be participating in dry January, but your skin most certainly will be feeling the dehydrating effects of the winter month. Between indoor heating systems and the brisk, cold outdoor air, your skin is crying out for a little extra love and attention. Give it what it needs with the help of some seriously dependable moisturizers. We rounded up five of our favorites to make it easy for you no matter your skin type.

The best all-around moisturizer is none other than EltaMDs Moisturizer. It soothes even the most sensitive skin thanks to its simple formula made with petroleum. Its the perfect pick for those who suffer from eczema and other skin concerns. It can even help promote healing following chemical peels, lasers and any other treatments! And depending on your application process, you can pick it up in a jar or tube for a super affordable price point.

Looking for a boost of radiance while you moisturize? South Korean cosmetics brand Laneige just launched its newest product: the Radian-C Cream with Vitamin C. Not only will it brighten your complexion, but it will also help diminish unwanted dark spots. Now thats what we call multitasking!

Though you may not think you need SPF throughout the winter months, especially when youre staying inside, experts disagree. Its a common misconception that you dont need to wear sunscreen when youre indoors, board-certified dermatologist Joyce Park told Allure. Standard glass windows block UVB but not UVA rays, which can penetrate deeper into the skin than UVB [rays], [and] are the main contributing factor to photo-aging which are changes seen as dark spots, wrinkles, and leathery textured skin.

But dont worry! Rihannas Fenty Beauty recently released a skincare line that includes a lightweight sunscreen. Its so comfortable, you wont even know you have SPF on. Well, except for its light, fresh, desert melon scent.

Keep scrolling to shop all top five of our favorite moisturizers to use this winter.

Listen on Spotify to Get Tressed With Us to get the details of every hair love affair in Hollywood, from the hits and misses on the red carpet to your favorite celebrities street style dos (and donts!)

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Everything you need to know about psychodermatology – acne prevention – Tatler

Posted: at 1:56 pm

Igor Ustynskyy / Getty Images

One of the great joys of boarding school is being with your friends 24 hours a day, seven days a week. But if youre a teenager with a highly visible skin disorder such as acne, constantly living under the gaze of your peers can be stressful. A recent study in an international journal specialising in dermatology showed that almost 90 per cent of 15-year-olds felt embarrassed and self-conscious about their acne, causing a quarter of them to avoid sport, swimming, and even social interactions and this could be exacerbated in a boarding environment.

The impact [for teenagers with skin disorders] can be devastating, leading to low mood, depression and social avoidance as well as the inevitable lack of self-esteem and self-belief, says Marina Gardiner Legge, headmistress of Heathfield School in Ascot.

The resilience and mental wellbeing of our teenagers is a growing concern. Mental health network, Emerging Minds: Action for Child Mental Health, recently reported that one in 10 children and young people have a diagnosable mental health problem, such as depression, anxiety or self-harm. Stress levels during the teenage years are compounded by the desire to fit in something that neuroscientist Professor Sarah-Jayne Blakemore explains in her book about the teenage brain, Inventing Ourselves, is a genuine physiological need at this stage of life.

While a highly visible skin condition can affect mental health, the emerging medical discipline of psychodermatology is revealing that, in turn, mental wellbeing also has an impact on our skin.

There are well-established, biochemical links between the experience of psychological stress and your skin, explains eminent psychodermatologist Dr Alia Ahmed of the Royal London Hospital and private Eudelo Clinics on Harley Street and in Vauxhall. When you feel stressed, your brain releases a number of chemicals and they kick off inflammation in your body and your skin. That inflammation is the driver for most skin diseases like eczema, psoriasis and acne. This then goes around in a vicious circle.

However, Dr Stefanie Williams, medical director at the Eudelo Clinic, cautions that we should not see stress as the sole cause of skin conditions. If you have a general tendency towards acne and other skin conditions, then stress such as exams can make it worse. But if you dont have any genetic acne predisposition at all, then stress wont cause you to breakout. In short, stress and other lifestyle factors can aggravate pre-existing acne, but does not cause it.

Psychodermatology treats skin conditions by combining traditional medicine with effective psychological techniques such as psychotherapy, mindfulness and cognitive behavioural therapy (CBT). Research shows that this combined treatment has physical and psychological benefits, with a 2014 British Association of Der- matologists study revealing that, among patients who completed psychodermatology therapies, nine out of 10 reported reduced stress, increased confidence and a better understanding of their condition.

It is a seminal theory but, in practice, teenagers are unlikely to link their skin condition to their mental health and, even if they do, may feel too self-conscious to visit a psychologist. The award-winning Teenage and Young Adult Dermatology Clinic at Oxford University Hospitals is looking to overcome these barriers, and reduce any stigma or embarrassment, by employing an on-site psychiatrist who is both accessible and low key.

I try to get all new patients to meet our in-house psychologist, so they can have a quick catch-up and explore if there is anything we can help them with, explains Dr Tess McPherson, a consultant dermatologist who leads the paediatric and adolescent service at the centre. Some will benefit from formal CBT, others will be referred to psychiatric care for antidepressants; some people just need a chat and a little bit of support, while others will be offered a course of mindful yoga.

One patient who has benefited from the holistic approach offered by this groundbreaking clinic is 18-year-old Miriam.

Ive always had eczema, and then it started getting really bad during secondary school, when I was in Year 7 or 8, she said. It was really lovely to find the centre I felt like Id finally got somewhere. Talking to Tess gave me so much more confidence than the GP ever had. She said, Well sort this out, and she had a whole plan I came out of there feeling better than I had in quite a while.

Like all the young patients at the clinic, Miriam met the resident psychologist shortly after her dermatology consultation. It was weird, because Ive had eczema since I was so little, Id never really thought about it as more than a skin problem or even an addiction all the scratching and touching my face, and all these little tics, she explains. I never considered it may be beneficial to think about it in a different way.

Delmaine Donson / Getty Images

CBT offered through psychodermatology clinics is one of the best ways to stop the itch-scratch-pick cycle that can lead to infection and scarring. In Miriams case, however, it was recommended that she listened to a specially prepared mindfulness CD every night. Through that concentration, the itch became less important and less on my mind and that helped, she says.

Psychodermatology has been transformational for Miriam. Yes, my eczema is still here, she explains. I have A-levels coming up and there are flare-ups, so Ive got to be careful, but Im in such a good routine now, thanks to Tess, that I can control it a lot better than I used to and so it affects me far less.

The impact of skin conditions on mental health can be serious, but psychodermatology is helping teenagers accept their skin and empowering them not to be held back by it. Though currently only available in a few specialist dermatology clinics, those patients whove been helped testify that the physical and mental benefits of psychodermatology are truly life changing.

For further information, visit: British Association of Dermatologists (bad.org.uk)Eudelo Clinics (eudelo.com)Oxford University Hospitals Dermatology Service (ouh.nhs. uk/services/departments/specialist- medicine/dermatology)Dr Linda Papadopoulos (drlinda.co.uk)

Leading psychodermatologist, psychologist and broadcaster Dr Linda Papadopoulos offers five ways to help teens overcome skin conditions

1. Be aware of the vicious cycle With some dermatological conditions, there is the potential for a vicious cycle to be set up whereby the worse our skin looks, the more stressed we get, and the more stressed we get, the worse our skin looks. Being aware of this and intervening, not just externally (with topical treatments), but also internally, through stress management and self-care, is vital.

2. Listen to your skin Get a diary and draw a line down the middle of the page. On one side, write down every time your skin flares up; down the other side, note what is going on in your life, how you are feeling, how busy, stressed or anxious you are. Compare to see if you can spot any patterns in your emotional state and skin health.

3. Dont put your life on hold Dont let your skin limit your world. Dont wait for it to clear up before you book the holiday, ask out the girl or go for that job interview. Instead, minimise the impact that it has on you by getting on with your life regardless.

4. Develop strategies to deal with uncertainty One of the hardest things is that you are constantly having to adapt to a change in appearance and, consequently, your body image. Engage in both short-term strategies like concealing or treatment but also in deeper, long-term strategies like pursuing activities you enjoy and finding support to talk about your feelings.

5. Dont be defined by the condition Skin conditions are often visible to others and, as a consequence, we may feel our condition begins to define us. It doesnt. Dont feel obliged to answer questions about it. Instead, when you engage with people, talk about your interests and the things that matter to you. If you are asked about it, have a stock answer that assures them that you are fine with it.

Here are a range of cosmetic solutions to help calm and control

LA ROCHE-POSAYEffaclar Duo[+]This anti-blemish moisturiser uses a natural prebiotic to balance skin bacteria and helps to prevent hormonal breakouts. 16. laroche-posay.co.uk

NATALIYA ROBINSONTeen Skin TreatmentThis facial to address early skin complaints is best for calming and controlling sensitive or acne-prone skin aimed at 12- to 19-year-olds. 130. nataliyarobinson.co.uk

DR ARIEL HAUSHydraFacialA prescriptive cleansing and skin nourishing treatment including adeep pore cleanse, exfoliation, hydration and key ingredients to control sebum production in the skin. 220. drhausdermatology.com

YOUNG LDNBespoke Acne FacialA customised treatment plan will ensure your concerns are taken care of both inside and out. From 78. youngldn.com

SKINADETargeted Solutions ClearDesigned to target specific concerns and support normal skin function. It is naturally flavoured with pineapple and available in 30-, 60- and 90-day courses. 90 for a 30-day course. skinade.com

This article first appeared in the Tatler's 2020 Schools Guide

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Is coconut oil good for your skin? How to use it effectively, based on your skin type – Insider – INSIDER

Posted: at 1:56 pm

People now use coconut oil in everything from food to skincare products. While coconut oil has benefits such as moisturizing and reducing inflammation, it can also clog pores. Some people with a tree nut allergy can have an allergic reaction to coconuts, so they should be wary of using coconut oil.

Before you start lathering coconut oil over your skin, here's what you need to know about coconut oil's potential effects.

There are two primary types of coconut oil: virgin and refined.

"Virgin coconut oil is made from fresh coconuts, and it is typically higher in content in polyphenols and antioxidants," says Michele Green, MD, a cosmetic dermatologist in New York City. "Refined coconut oil is made from dried coconut meat. Refined coconut oil goes through more processing steps, including machine pressing to obtain the oil." In some instances, bleaching and chemical solvents are added to refined coconut oil.

Coconut oil can also be labeled as cold-pressed when produced without heat. "This type may be richer in nutrients," says Green. Thanks to greater amounts of polyphenols and antioxidants, as well as its limited processing, virgin coconut oil, especially when cold-pressed, is a better choice for use on the skin.

While coconut oil can provide dermatological benefits, it may not be right for everyone. We've broken down the benefits and detriments of using coconut oil on your skin and how to decide if it's right for you.

Applying coconut oil to your skin can help retain moisture. This is because coconut oil contains a component of ceramides, called linoleic acid.

Ceramides are organic compounds naturally found in the skin and commonly added to skin care. "Ceramides help to strengthen the skin barrier and minimize moisture loss," says Tsippora Shainhouse, MD, a dermatologist at SkinSafe Dermatology and Skin Care in Los Angeles.

In a small 2004 study, participants used virgin coconut oil on their legs twice a day for two weeks. At the end of the two weeks, skin hydration had significantly improved. Coconut oil can be particularly good for people with eczema or chronically dry skin.

Coconut oil can also reduce skin inflammation, which causes rashes, redness, or itching, among other symptoms.

"It helps to strengthen the skin barrier, which minimizes irritants from entering the skin and maintains skin hydration, both of which work to reduce potential inflammation," says Shainhouse.

Common skin conditions that involve inflammation include:

These conditions can each be soothed, at least temporarily, by coconut oil. In a 2018 study, virgin coconut oil suppressed skin's anti-inflammatory properties and enhanced skin barrier function. However, the study was conducted in vitro outside of a living organism so the exact effect on humans is unknown.

"Coconut oil also contains lauric acid, which has mild antibacterial and antifungal properties," says Shainhouse.

Coconut oil's antibacterial and antifungal properties can be misleading. "For these reasons, coconut oil is often touted as helpful for acne," says Brooke Jeffy, MD, a dermatologist at Spectrum Dermatology in Phoenix. However, acne is the result of clogged pores, which coconut oil can cause.

Coconut oil is comedogenic, meaning it can clog your pores, increasing your risk of breakouts and acne.

"Coconut is considered a four on the comedogenic scale. This measures how pore-clogging an ingredient is, rated zero to five with five being the most pore-clogging," says Green. As a result, using coconut oil frequently, especially on the face, is not recommended, she says.

Though coconut oil is comedogenic, not everyone will experience acne from it as each skin type will react differently.

Coconut oil will affect everyone's skin differently, therefore, it may not be the best addition to everyone's skincare routine. Here's how to use coconut oil based on your skin type.

People with eczema: Thanks to its moisturizing and anti-inflammatory properties, you can use coconut oil to soothe eczema flare-ups. In a 2013 study, applying virgin coconut oil to the skin of children with eczema for eight weeks improved the skin's hydration.

People with dry skin: "If you have dry, flaky skin, using coconut oil instead of your regular moisturizer may soften and hydrate your skin, leaving it looking refreshed and soft upon waking," says Green.

People with diabetes: "Diabetics with dry, scaly feet may tolerate this natural oil to moisturize and prevent skin barrier breakdown, which could otherwise leave them at risk for skin and foot infection," says Shainhouse. However, since people with diabetes can lose sensation in their feet, the skin should be carefully monitored for irritation or allergic reactions.

People with acne-prone or oily skin: "For acne-prone individuals, coconut oil can clog pores and trigger acne flares. If you do choose to use coconut oil as part of your double-cleansing routine to remove oil-soluble makeup, be sure to wash off any residual coconut oil completely," says Shainhouse.

Oily skin can already be more prone to clogged pores, and coconut oil may add to the problem.

If you do try coconut oil, there are a few ways to add it to your routine. According to Shainhouse, you can use coconut oil on your skin in the following ways:

If you have acne-prone or oily skin and should avoid using coconut oil on your face, Jeffy recommends applying it to areas with thicker skin, such as the elbows, knees, feet, nails, and cuticles.

"Coconut oil can be used as a body lotion or lip balm, but if breakouts start happening, it would be the first thing to stop," says Jeffy. "If someone feels really strongly that they want to be using coconut oil on the skin, looking for it as an ingredient in a product versus using the pure oil may be less likely to contribute to problems."

Coconut oil, especially virgin coconut oil, can have beneficial properties for the skin, such as boosting hydration. However, for people with acne-prone or oily skin, it can further clog pores and increase breakouts. Using coconut oil on thicker skin, such as the legs, may lead to less irritation.

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Itchy bum cheeks: Causes, treatment, home remedies, and more – Medical News Today

Posted: at 1:56 pm

Having itchy buttocks is usually not a cause for concern. However, it may occur due to some conditions that affect the skin, such as contact dermatitis, folliculitis, and more.

This article will go over the potential causes of itchy buttocks. It will also outline the treatment options and when to see a doctor.

Contact dermatitis occurs when a persons skin comes into contact with something that causes an allergic reaction.

Symptoms of contact dermatitis include:

If a person has repeated exposure to an allergen, they may also experience:

Some common causes of contact dermatitis include poison ivy, nickel, latex, and soaps.

Learn more about contact dermatitis here.

If possible, a person should avoid the substance that caused the rash to appear.

A doctor may also treat a persons contact dermatitis using:

Folliculitis is a common skin infection that affects hair follicles.

Buttock folliculitis can be acute or chronic:

This usually occurs due to bacteria and results in painful pustules and papules.

A person can take antibiotics to treat acute buttock folliculitis.

This does not typically cause severe symptoms, but it can be persistent.

Treatment includes:

Hot tub folliculitis appears when the hair follicles come into contact with contaminated water. It typically affects children more so than adults.

A person can get hot tub folliculitis from hot tubs, whirlpools, and waterslides.

The symptoms include itchy and flushed bumps that can develop into painful nodules. They may also be filled with pus.

Hot tub folliculitis usually clears up without treatment in 510 days.

However, if the rash does not go away or if a person grows concerned, they should speak with a doctor.

Treatments for hot tub rash include:

Ringworm is a type of contagious fungal infection. It can appear anywhere on the skin, and without treatment, it can spread across the body.

Symptoms of ringworm around the groin and buttocks, or jock itch, include:

Learn more about jock itch here.

A person who has ringworm may wish to contact a doctor regarding treatment. The doctor may treat ringworm with antifungal cream or medicine.

The Centers for Disease Control and Prevention (CDC) note that scabies is a skin infection that occurs due to the human itch mite, or Sarcoptes scabiei var. hominis.

People may experience itching and a rash on the:

Itching and a rash may also affect the area between the fingers or under the armpit.

Symptoms of scabies include:

Learn more about scabies here.

A person can treat scabies using scabicides, which are medications that kill the mites and the eggs.

These medications come in the form of a cream or lotion.

Dermatitis herpetiformis, also known as Duhrings disease, is a chronic skin condition that occurs as a reaction to eating gluten. It occurs in 1015% of people with celiac disease.

Dermatitis herpetiformis causes extremely itchy bumps to appear on the forearms, knees, buttocks, and hairline.

Learn more about dermatitis herpetiformis here.

A person with dermatitis herpetiformis should follow a gluten-free diet to help their symptoms.

A doctor may also prescribe dapsone, which is a sulfone antibiotic.

Porokeratosis ptychotropica is a rare skin condition that affects the buttocks.

A person with porokeratosis ptychotropica will experience scaly or warty plaques on the buttocks. They may also experience itching. The condition may affect the lower legs as well.

Healthcare professionals do not yet know the cause. However, this condition may occur due to:

There is currently no cure for porokeratosis ptychotropica. However, doctors may suggest the following:

Cutaneous larva migrans is a parasitic skin infection. It occurs when a person comes into contact with hookworm larva, usually via soil or sand.

Once the larva has entered a persons skin, it travels beneath the surface, causing itchy red tracks. These tracks usually appear on a persons feet or buttocks.

The larvae cannot mature inside a human host and will eventually die. However, a doctor can treat a person with cutaneous larva migrans using:

To soothe itchy skin at home, a person can try the following:

However, a person should seek guidance from a doctor to receive proper treatment.

The doctor may ask the person questions about their medical history and any symptoms they have.

The doctor may also take skin samples from the affected area to help diagnose any skin conditions.

If the itching is persistent, a person should contact a doctor.

A person should also speak with a doctor if the itching is causing discomfort or if they are experiencing additional symptoms.

Itchy buttocks can also occur alongside a rash.

According to the American Academy of Dermatology Association, a person should seek immediate medical attention if they have a rash that:

A person should also seek immediate medical attention if they have difficulty breathing or a swollen face or eyes. This is the result of a severe allergic reaction.

Usually, itchy buttocks are not a cause for concern. However, certain conditions can cause the buttocks to become itchy.

A person who is concerned about itchy buttocks should consult a doctor. The doctor will be able to discuss potential causes and treatment options.

If a person notices any serious symptoms regarding a rash they have, they should seek immediate medical attention.

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Former GOP congressman urges Never Trumpers to join Libertarian Party – Washington Times

Posted: at 1:56 pm

Former Rep. Justin Amash, who repeatedly sparred with President Trump during his time in office, called Thursday for Republicans to join the Libertarian Party.

Mr. Amash represented Michigans 3rd Congressional District from 2011 to 2021. He was a Republican but ended up leaving the party and becoming an independent in 2019 before officially joining the Libertarian Party last year over his opposition to Mr. Trump.

The GOP isnt getting better anytime soon. If youre a Republican whos had enough, join me in the Libertarian Party. Reach out to me. Im happy to answer questions about making the switch. Were readying to make a big impact over the next few years, he said on Twitter.

Mr. Amash voted to impeach Mr. Trump in 2019 over the Ukrainian scandal.

He has toyed with running for the presidential nomination for the Libertarian Party.

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Letter to the editor: There are options to political dissatisfaction – Jacksonville Journal-Courier

Posted: at 1:56 pm

Journal-Courier staff, dbauer@myjournalcourier.com

Letter to the editor: There are options to political dissatisfaction

To the editor:

The Non-Aggression Principle is a central philosophy of Libertarianism. It is defined that any aggression initiated by force, threats or coercion to make any forceful interference with either a person or their property is inherently wrong. It does not forbid forceful defense.

There are several arguments around the principles definitions and philosophy, which is encapsulated within each of the different caucuses of the Libertarian Party. Like both major parties, we have many competing ideologies. It can sometimes lead to the frustrations we commonly see in the world of politics and to the gridlock that slows down the machinations of government. We are not a perfect party, but we do have a large tent to welcome all who wish to join.

Like the rioting and burning that took place in several major cities across the country this past summer, the Morgan County Libertarians condemn any and all acts of violence and destruction, especially those that occurred in our nations capital this week. We are against the initiation of force to achieve political or social goals. There are real grievances on both sides of the political spectrum that need to be earnestly and honestly addressed in the highest echelons of our government. Both sides have exploited the government to their own benefit and have disregarded and disenfranchised others. Those loopholes and deficiencies in our laws must be stopped and things must be changed. Libertarians wish to see a very different government and set of public policies that listen to all grievances and petitions with equality and fairness. Libertarians are committed to achieving that end peacefully by persuasion, peaceful protest and demonstration, and through winning elections at all levels of government.

It is time for you, dear reader, to decide if you wish to continue the madness of voting against your own self-interests through re-electing Democrats and Republicans or if you are willing to try something more principled.

If you are a Republican that is shocked and angered by your party giving succor to an authoritative, seditious tyrant wishing to overthrow the general tenants of our democracy, inciting a cult-mob to acts of violence to retain power, or are a Democrat that feels that socialism is a failed economic philosophy that will only take more of your money and expand the size of government and debt your grandchildren will owe or are simply a common citizen that is tired by the response from both parties saying more government is the solution to all of the nations ills, there is another way. If you want a party that follows the Constitution and wants to leave you alone to live your life as you see fit as long as you are not hurting anybody else, please reach out to the Morgan County Libertarians or the Illinois Libertarian Party.

Even if you are not convinced, simply ask questions you may be surprised by the answers.

Ben Cox

Jacksonville

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Low fitness linked to higher psoriasis risk later in life – Newswise

Posted: at 1:53 pm

Newswise In a major register-based study, scientists at University of Gothenburg, Sweden, have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. For the male recruits to compulsory military training who were rated as the least fit, the risk of developing psoriasis later was 35 percent higher than for the fittest.

The study was based on data on more than 1.2 million men conscripted, aged 18, into the Swedish Armed Forces between the years 1968 and 2005. During the enrollment process, all these young men underwent the same fitness test on an exercise bicycle. The researchers divided the data, according to how fit the men were, into three levels (low, medium, and high fitness). They then merged the data with other registers, using Sweden's National Patient Register to obtain diagnostic codes for psoriasis and the joint disease psoriatic arthritis. The men who had already received one of these diagnoses before conscription were excluded from the study.

Later in life, between the ages of 37 and 51, just over 23,000 of the conscripts developed psoriasis or psoriatic arthritis. In the low-fitness group, 2.5 percent developed one or both of these diseases, while only 1.7 percent in the high-fitness group did so. In calculating this risk differential, the scientists adjusted for other risk factors, such as body mass index (BMI).

Association not causal

Thus, the less fit the men were when they were recruited, the higher the proportion of them who later fell ill with psoriasis or psoriatic arthritis. In the low-fitness group, the risk of developing psoriasis was 35 percent higher, and that of developing psoriatic arthritis 44 percent higher, than in the high-fitness group.

"We show that there's an association between lower fitness and raised risk of developing psoriasis and psoriatic arthritis, but we don't show a causal connection. So we can't say that these health conditions can be prevented by exercising," says the study's first author Marta Laskowski, a doctoral student in dermatology at the University of Gothenburg and resident physician (specialist trainee) at Sahlgrenska University Hospital.

Group in need of monitoring

The group of men who were least fit was also the smallest: just under 48,000 or 3.9 percent of all the conscripts in the study. This is a group that healthcare services should try to monitor regularly.

"Low fitness was already known to boost the risk of incurring cardiovascular disease, and psoriasis as such is linked to raised cardiovascular disease risk, too. The results from our study confirm the reasons for assessing people's fitness early in life, to identify individuals at a higher risk for adverse health outcomes later in life," Laskowski says.

Previous research has indicated that, in general, people with psoriasis are less fit than those without it who engage in an equal amount of physical activity. However, the reasons for this difference have not been fully clarified.

"One weakness of our study is that we weren't been able to monitor the trends of the men's fitness during the intervening years, between their conscription and the disease onset. We're also lacking data on smoking, which is a known risk factor for psoriasis," Laskowski explains.

Scaly skin patches

Some 300,000 Swedes have psoriasis in a mild, moderate, or severe form. It is a chronic, systemic inflammatory disease that affects women as often as men. What triggers its onset is not entirely clear, but heredity is known to play a large part in combination with external factors. The most common type, plaque psoriasis, causes reddened, flaking, and itchy skin lesions ("plaques").

Psoriasis sufferers also often have other diseases. Some 30 percent get the inflammatory joint condition known as psoriatic arthritis. Examples of other known comorbidities are obesity, cardiovascular disease, diabetes, and depression.

In recent years, treatment options have substantially improved. Today, besides ointments with local effects, there are drugs that have systemic effects. Recent years have also seen the emergence of efficacious biological agents that modulate the signaling cascade in the inflammatory process that drives psoriasis.

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Psoriasis Drugs Industry Market size and Key Trends in terms of volume and value – Business-newsupdate.com

Posted: at 1:53 pm

Psoriasis Drugs Industry Market size and Key Trends in terms of volume and value 2020-2025

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Amgen Inks $240 Million Autoimmune Deal with Tiny EVOQ Therapeutics – BioSpace

Posted: at 1:53 pm

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Amgen is partnering with Ann Arbor, Michigan-based EVOQ Therapeutics for a license and collaboration deal to discover and develop drugs for autoimmune disorders. Amgen is paying EVOQ $240 million up front in addition to royalties on subsequent sales.

EVOQs focus is on autoimmune diseases, although its original intent was targeting oncology. It is a spinoff from the University of Michigan (U of M) in 2016. It was co-founded by James Moon and Anna Schwendeman, both from U of M. Moon is the chief scientific officer and Schwendeman is the vice president of preclinical development. William Brinkerhoff is also a co-founder and acts as the chief executive officer. Their technology platform is called NanoDisc, a high-density lipoprotein platform, that they believe can be used to deliver peptides directly into the lymph nodes.

The two companies will work together to use dendritic cells to develop immune tolerance. The companys in-house pipeline includes two compounds that target MOG antibody disease, a new condition that results in neuro-spinal swelling and is typically misdiagnosed as multiple sclerosis (MS), and type 1 diabetes.

A big driver of Amgens autoimmune portfolio is Otezla (apremilast). Amgen acquired Otezla for moderate-to-severe plaque psoriasis and psoriatic arthritis in November 2019 from Celgene. Bristol Myers Squibb acquired Celgene, but was forced by the U.S. Securities and Exchange Commission (SEC) to divest Otezla because of a competing product in their pipeline, deucravacitinib (BMS-986165). In fact, in November 2020, deucravacitinib beat out Otezla in the POETYK PSO-1 Phase III clinical trial in one of the key secondary endpoints. The drug otherwise hit the co-primary endpoints on psoriasis.

Amgen paid $13.4 billion in cash for access to Otezla, which is approved in the U.S. for moderate-to-severe plaque psoriasis patients who are candidates for phototherapy or systemic therapy; adults with active psoriatic arthritis; and adults with oral ulcers associated with Behcets disease. The drug is approved in more than 50 markets outside the U.S. and has patent protection through at least 2028 in the U.S. In 2018, Otezla sales were $1.6 billion.

In other news, Amgen announced new data from its oncology pipeline in lung cancer will be presented at the 2020 World Conference on Lung Cancer (WCLC) from January 28-31, 2021. That will include Phase II data from the CodeBreaK 100 clinical trial of sotorasib in KRAS G12C-mutated advanced non-small cell lung cancer (NSCLC). They will also describe updated Phase I data from AMG 757, a first-in-class BiTE molecule that targets delta-like ligand 3 (DLL3) in small cell lung cancer (SCLC).

We are incredibly excited to present the first complete Phase II non-small cell lung cancer data set for an investigational KRAS G12C inhibitor, including novel biomarker analyses, said David M. Reese, executive vice president of Research and Development at Amgen. This is an historic moment not only for us, but for the scientific community working on the 40-year quest to target KRAS, one of cancer researchs toughest challenges. Additionally, following recent regulatory submissions to the FDA and European Medicines Agency, we remain focused on rapidly bringing this potential foundational KRAS G12C therapy to patients with advanced non-small cell lung cancer harboring this mutation.

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National Psoriasis Foundation COVID-19 Task Force Guidance for Management of Psoriatic Disease During the Pandemic: Version 2 – Advances in Psoriatic…

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J Am Acad Dermatol. 2021 Jan 7:S0190-9622(21)00016-5. doi: 10.1016/j.jaad.2020.12.058. Online ahead of print.

ABSTRACT

OBJECTIVE: To update guidance regarding the management of psoriatic disease during the COVID-19 pandemic.

STUDY DESIGN: The task force (TF) includes 18 physician voting members with expertise in dermatology, rheumatology, epidemiology, infectious diseases, and critical care. The TF was supplemented by non-voting members, which included fellows and National Psoriasis Foundation (NPF) staff. Clinical questions relevant to the psoriatic disease community were informed by inquiries received by the NPF. A Delphi process was conducted.

RESULTS: The TF updated evidence for the original 22 statements and added 5 new recommendations. The average of the votes was within the category of agreement for all statements, 13 with high consensus, 14 with moderate consensus.

LIMITATIONS: The evidence behind many guidance statements is variable in quality and/or quantity.

CONCLUSION: These statements provide guidance for the management of patients with psoriatic disease on topics ranging from how the disease and its treatments impact COVID-19 risk, how medical care can be optimized during the pandemic, what patients should do to lower their risk of getting infected with SARS-CoV-2 (including novel vaccination), and what they should do if they develop COVID-19. The guidance is a living document that is continuously updated by the TF as data emerge.

PMID:33422626 | DOI:10.1016/j.jaad.2020.12.058

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National Psoriasis Foundation COVID-19 Task Force Guidance for Management of Psoriatic Disease During the Pandemic: Version 2 - Advances in Psoriatic...

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