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What is DNA?: MedlinePlus Genetics
Posted: January 19, 2021 at 9:11 am
DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a persons body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). Mitochondria are structures within cells that convert the energy from food into a form that cells can use.
The information in DNA is stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T). Human DNA consists of about 3 billion bases, and more than 99 percent of those bases are the same in all people. The order, or sequence, of these bases determines the information available for building and maintaining an organism, similar to the way in which letters of the alphabet appear in a certain order to form words and sentences.
DNA bases pair up with each other, A with T and C with G, to form units called base pairs. Each base is also attached to a sugar molecule and a phosphate molecule. Together, a base, sugar, and phosphate are called a nucleotide. Nucleotides are arranged in two long strands that form a spiral called a double helix. The structure of the double helix is somewhat like a ladder, with the base pairs forming the ladders rungs and the sugar and phosphate molecules forming the vertical sidepieces of the ladder.
An important property of DNA is that it can replicate, or make copies of itself. Each strand of DNA in the double helix can serve as a pattern for duplicating the sequence of bases. This is critical when cells divide because each new cell needs to have an exact copy of the DNA present in the old cell.
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Applied DNA Provides Business Update on COVID-19 Diagnostics and Testing – BioSpace
Posted: at 9:11 am
Jan. 15, 2021 12:00 UTC
STONY BROOK, N.Y.--(BUSINESS WIRE)-- Applied DNA Sciences, Inc.(NASDAQ:APDN) (the Company), a leader in Polymerase Chain Reaction (PCR)-based DNA manufacturing, today announced that its safeCircle pooled surveillance testing service has seen a 158% increase in the daily average number of tests performed to date in January 2021 compared to December 2020. The increase is chiefly the result of the scale-up of certain testing contracts and from the acquisition of new clients. Launched in the fourth quarter of fiscal 2020 (ended September 30, 2020), safeCircle now counts 33 primary/secondary/higher education institutions, private client, local government, and businesses as clients.
Concurrently, the Company stated that it is increasing production of its Linea COVID-19 Assay Kit (the Assay Kit) and sample collection kits to meet expected demand from existing customers, from its safeCircle service that is powered by the Assay Kit, and due to heightened interest in the Assay Kit following a recent U.S. Food & Drug Administrations Food & Drug Administration (FDA) alert that identified the assay as an EUA-approved molecular diagnostic test that can potentially identify certain SARS-CoV-2 mutations (the FDA Alert). The Company also said that Applied DNA Clinical Laboratories, LLC (ADCL), its wholly-owned subsidiary, is on track to submit a request for CLEP-CLIA re-inspection during the current quarter ending March 31, 2021. If granted, CLEP-CLIA certification would enable ADCL to serve as a diagnostic laboratory that would allow for it to conduct diagnostic COVID-19 testing.
Positive business trends for safeCircle have carried over into January and are further enhanced by the growing awareness of our platform regionally and through our partnership with CLEARED4. The profile of prospective clients is changing with more and larger opportunities in our sales pipeline, said Dr. James A. Hayward, president and CEO.
The FDAs recent Alert has the potential to be a catalyst to revenue, concluded Dr. Hayward. We believe our assay is one of the few cost-effective and rapid ways a laboratory can detect S-gene target dropout that serves as a potential indication of a SARS-CoV-2 variant, including the U.K.s B.1.1.7 that is characterized by increased transmissibility. We believe the ability to identify new potential COVID-19 variants with an EUA-approved molecular diagnostic test that is in-market today is essential in the continuing fight against COVID-19. Diagnostic labs using molecular diagnostic tests that do not have the ability to discriminate potential COVID-19 variants from wildtype are unable to quickly and easily identify patients that are potentially infected with a more infectious variant, which we believe may lead to further infection spread.
safeCircle Pooled Surveillance Testing Service
In recent weeks safeCircle has added new clients. They include:
Ramp Up in Production of Kits utilized in COVID-19 Sample Collection
The Company is also increasing the production of sample collection kits utilized in surveillance testing by a factor of four to meet the testing scale-up of the Assay Kits largest customer and for use by new safeCircle clients.
CLEARED4 Partnership Generating New Clients
Applied DNAs recently announced partnership with CLEARED4, a provider of return-to-work health safety solutions, has begun to bear fruit. In addition to being utilized as a mobile-friendly, value-added option for the management of aggregate results testing and reporting to a key safeCircle client, Applied DNA is now providing CLEARED4 services to a second safeCircle client, the aforementioned jewelry company. Applied DNA expects to onboard a third new client this week, the aforementioned private higher education institution. The Company believes that the combination of its safeCircle offering with the CLEARED4 platform is a compelling service in a marketplace that is in search of an accurate, easy-to-employ, faster-turnaround testing service that incents participation.
Linea COVID-19 Assay Kit (Test) Production
The Companys largest customer for its Assay Kit expects to increase its use of the Assay and sample collection kits for its in-house surveillance testing program beginning in early February 2021 to coincide with its campus reopening for the Spring semester. The customers in-house program oversees the weekly surveillance testing of thousands of faculty and staff for the presence of COVID-19. Applied DNA receives recurring replenishment orders from the customer for both Assay and sample collection kits to meet its in-house surveillance testing needs.
In response to the FDA Alert, the Company is relaunching its sales and marketing strategy to center on the Assay Kits potential ability to signal for the presence of a SARS-CoV-2 variant due to S-gene target dropout. Refreshed Frequently Asked Questions are available for reference for prospective diagnostic laboratory customers nationally at https://adnas.com/sars-cov-2-69-70del-mutation-covid-assay-kit/.
Update on Applied DNA Clinical Laboratories (ADCL) CLEP-CLIA Certification
The Company is in the process of completing remediation of deficiencies in ADCLs clinical standard of practice and expects to submit a request for re-inspection during the current quarter ending March 31, 2021. CLEP-CLIA certification will enable ADCL to capture diagnostic COVID-19 revenues currently being conducted by third party clinical labs. CLEP-CLIA certification would also potentially allow ADCL to develop an additional revenue stream through the development and commercialization of a broad-array of diagnostic tests, as laboratory-developed tests (LDTs), that once approved by the applicable regulatory authority, could be offered by ADCL.
About the Linea COVID-19 Assay Kit and Pooled Surveillance Testing
The Linea COVID-19 Assay Kit is authorized by FDA EUA for the qualitative detection of nucleic acid from SARS-CoV-2 in respiratory specimens, including anterior nasal swabs, self-collected at a healthcare location or collected by a healthcare worker, and nasopharyngeal and oropharyngeal swabs, mid-turbinate nasal swabs, nasopharyngeal washes/aspirates or nasal aspirates, and bronchoalveolar lavage (BAL) specimens collected by a healthcare worker from individuals who are suspected of COVID-19 by their healthcare provider. The scope of the Linea COVID-19 Assay Kit EUA, as amended, is expressly limited to use consistent with the Instructions for Use by authorized laboratories, certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) to perform high complexity tests. The EUA will be effective until the declaration that circumstances exist justifying the authorization of the emergency use of in vitro diagnostics for detection and/or diagnosis of COVID-19 is terminated or until the EUAs prior termination or revocation. The diagnostic kit has not been FDA cleared or approved, and the EUAs limited authorization is only for the detection of nucleic acid from SARS-CoV-2, not for any other viruses or pathogens.
The Company is offering surveillance testing in compliance with current CDC, FDA, and CMS guidances. The use of saliva and pooled sampling for surveillance testing, which has been internally validated by the Company in compliance with current surveillance testing guidances, is not included in the Companys EUA authorization for the Linea COVID-19 Assay Kit.
About Applied DNA Sciences
Applied DNA is a provider of molecular technologies that enable supply chain security, anti-counterfeiting and anti-theft technology, product genotyping, and pre-clinical nucleic acid-based therapeutic drug candidates.
Visit adnas.com for more information. Follow us on Twitter and LinkedIn. Join our mailing list.
The Companys common stock is listed on NASDAQ under ticker symbol APDN, and its publicly traded warrants are listed on OTC under ticker symbol APPDW.
Applied DNA is a member of the Russell Microcap Index.
Forward-Looking Statements
The statements made by Applied DNA in this press release may be forward-looking in nature within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. Forward-looking statements describe Applied DNAs future plans, projections, strategies, and expectations, and are based on assumptions and involve a number of risks and uncertainties, many of which are beyond the control of Applied DNA. Actual results could differ materially from those projected due to its history of net losses, limited financial resources, limited market acceptance, the possibility that the assay kit could become obsolete or have its utility diminished, the uncertainties inherent in research and development, future clinical data and analysis, including whether any of Applied DNAs or its partners diagnostic candidates will advance further in the preclinical research or clinical trial process, including receiving clearance from the U.S. Food and Drug Administration (U.S. FDA) or equivalent foreign regulatory agencies to conduct clinical trials and whether and when, if at all, they will receive final approval from the U.S. FDA or equivalent foreign regulatory agencies, the unknown outcome of any applications or requests to U.S. FDA, equivalent foreign regulatory agencies and/or the New York State Department of Health, the unknown limited duration of any Emergency Use Authorization (EUA) approval from U.S. FDA, changes in guidances promulgated by the CDC, U.S. FDA and/or CMS relating to COVID-19 surveillance and diagnostic testing, disruptions in the supply of raw materials and supplies, and various other factors detailed from time to time in Applied DNAs SEC reports and filings, including our Annual Report on Form 10-K filed on December 17, 2020, and other reports we file with the SEC, which are available at http://www.sec.gov. Applied DNA undertakes no obligation to update publicly any forward-looking statements to reflect new information, events, or circumstances after the date hereof or to reflect the occurrence of unanticipated events, unless otherwise required by law.
View source version on businesswire.com: https://www.businesswire.com/news/home/20210115005079/en/
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‘We all need to wake up’: Advocacy, activism are part of new Tigers coach Lombard’s DNA – The Detroit News
Posted: at 9:11 am
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Detroit There may not be a more fitting day to introduce or reintroduce for fans of a more aged vintage new Tigers bench coach George Lombard than on Martin Luther King Day. That's because the late Posy Lombard, a white woman from a wealthy New England family who became a legendary activist in the American civil rights movement, is his mother.
Posy Lombard, who was killed in a car accident at age 41, when George was 10, marched with Dr. King in 1963. She was a congressional intern. She went to civil rights seminars to hear Malcolm X. She was arrested in Montgomery, Ala., in 1965, for protesting the Bloody Sunday beatings in Selma. Later she was arrested twice for protesting racial injustice in Natchez, Miss., where she famously stared down members of the Ku Klux Klan that blocked her attempts at integrating a neighborhood playground. She helped affect positive change in the Deep South.
George Lombard was hired as bench coach by new Tigers manager AJ Hinch.(Photo: Elsa, Getty Images)
Your mom was a bad-ass, former Tiger David Price texted Lombard during the baseball shutdown last summer.
The mention of that text raised goosebumps on George Lombards arms Sunday during a Zoom interview.
More: Tigers sign former Red Sox lefty Robbie Ross to minor-league deal
Just being a difference-maker, said Lombard, who spent the last five years going to three World Series and winning one with the Los Angeles Dodgers last October. Jackie Robinson. Martin Luther King. My mom lived such a short life and impacted so many people.
With my story coming out, it was just a chance to change some minds and to move so many people.
More: Tigers splash cash in signing 17-year-old international shortstops Santana, Bastidas
Lombard, though certainly aware of his mothers history his older brother and younger sister worked to obtain a thick file the FBI had on his Posy had never made her story public, never made it part of his story.
Until COVID-19 happened. Until Ahmaud Arbery, Jacob Black and George Floyd happened. Until Black Lives Matter happened.
A police booking photo of Posy Lombard after she was arrested in Montgomery, Alabama.(Photo: Los Angeles Daily News)
Here we are, 50 years later, and were still fighting the same fight, he said. Which is a bit embarrassing. We all need to wake up and understand what is happening.
Lombard, who played for the Tigers in 2002, spent the early days of the pandemic researching his mothers life. He knew he wanted to use her story as a base for his own advocacy efforts. He knew, as a big-league coach, he had a platform. It just wasnt in his nature to jump up on that platform and speak to large groups.
More: Tigers avoid arbitration with all nine eligible players
Especially about his childhood. Posy was raising the three children by herself. All of a sudden, she was gone and their father, Paul Williams, an autoworker who had been living elsewhere, was moving back in. Lombard remembers being in an Atlanta courtroom and a judge asking him if he wanted to keep the name Lombard or use their fathers name Williams.
More: Ex-Tigers help throw iconic Detroit columnist Pete Waldmeir a 90th birthday bash
Those are tough questions to answer at a young age, he said. But Im 45 now and I realize the decisions Ive made throughout my life had a great deal to do with the way my mother raised us.
Lombard, with the help of renowned mental skills trainer Lucas Jadin, gradually started bringing his and his mothers story into the light. First a feature story in the Los Angeles Daily News. Then ESPN gave it a national ride. Within the clubhouse, Price was the first one Lombard opened up to about it.
Former Tigers pitcher David Price was instrumental in telling players the story of George Lombard's mother Posy, who was a strong advocate in the fight for civil rights.(Photo: Carlos Osorio, AP)
Pricey was great, he was the one who really pushed the story to the players, Lombard said.
After taking part in a peaceful march for justice in Scottsdalethis summer, Price, as reported in the ESPN story, texted Lombard: George, I just wanted to let you know that my family and I did a peaceful protest in honor of your mom's name. I can't tell you how many shapes, sizes, colors, religions, ethnicities however you identify, everybody was out there. We were together as one, and that's the way it needs to be."
More: Power up: Tigers pitcher Michael Fulmer done being skinny
Lombard told ESPN, "I told my wife it was my greatest moment as a coach. I was almost in tears."
Its been the most emotional six months that Ive had, Lombard said on Sunday.
Culminating, of course, with a World Series championship with the Dodgers.
I was part of five years in L.A. where we went to five playoffs and three World Series just to win one, he said. Thats just to explain the difficulty of winning at that level. It was eye-opening.
The Tigers had gotten permission to interview Lombard for the open manager job earlier in the playoffs. And although Lombard made it clear that his sole focus at the time was on trying to win a ring with the Dodgers and he hadnt had time to properly research the Tigers' job, he impressed both general manager Al Avila and assistant general manager David Chadd.
David Chadd called me and said they had hired AJ Hinch, but would I have any interest in being a bench coach, Lombard said. They loved my interview. That came out of the blue because I pictured myself being with the Dodgers for many years.
George Lombard played for the Tigers in 2002.(Photo: Al Bello, Getty Images)
Having won a ring with the Dodgers, having managerial ambitions, with the mutual admiration and history he has with Hinch, and with Detroit a heck of a lot closer to his family in Georgia than Los Angeles it ended up being an easy call to accept the Tigers job.
I have so much gratitude for (Dodgers president) Andrew Friedman and (manager) Dave Roberts for giving me my first Major League coaching job, Lombard said. But they both pushed on me that it was important for me to get into a position where I could start making decisions and take on more responsibility.
And with AJ, I think hes going to be a great person for me to learn from and to teach me the Xs and Os of the game.
Detroit is a trigger point of a lot of memories for Lombard, memories from his playing days. He was traded from the Braves to the Tigers on June 19, 2002. The Braves and Tigers happened to playing each other that day in Atlanta. He just walked from the home clubhouse to the visitor's clubhouse.
Lombard has the distinction of taking batting practice for both teams, first in a Braves uniform and then in a Tigers uniform, before the same game.
Later that summer, Lombard made his first visit to Boston as a big-leaguer. He hadnt been back to New England since the summer his mother died. On July 7, with his mothers family, his grandparents, in the stands, he clubbed a massive home run off pitcher Sun Woo-Kim in the third inning that cleared the wall in center field.
That was unquestionably one of the highlights of my career," he said. "The ball hit off the cameramans leg. The trainer got the ball and his wife did a lot of artwork on it. I still have it.
That was one proud moment for my grandfather, just to see the Lombard name all over the paper. Also, that was the summer Ted Williams died. I have a picture that ran in the Boston Globe of me batting against Pedro Martinez with the flag at half-mast in the background.
And now, as best he can, in his own way, Lombard is carrying the torch of advocacy that his mother helped light 50 years ago.
All of us see things, he said. There are things weve noticed over the last year or so, starting with COVID and the racial injustices. I hope its opened up our eyes to the way we should live our life.
Lombard, above all else, wants to facilitate conversations about justice. He wants to create and sustain awareness. He does it by words and deeds. The cleats he wore last season bore the images of his mother on his left heel and civil rights leader John Lewis on his right.
We can make a difference every day and it doesnt have to be going out and marching for the civil rights movement, he said. It can be as simple as helping out one of your teammates, helping the community or just helping some kid.
We have to be more educated on the subject. I need to be better. I need to teach and overcome some of the things we are going through today. We need to be more educated on that, and thats what I take pride in doing.
Its also, from a leadership standpoint, about listening.
Great leaders are great listeners, he said. Thats where it starts. Before we can open up our minds and hearts, we need to be better listeners. We all know that. But hearing it and reemphasizing it is important.
Twitter: @cmccosky
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'We all need to wake up': Advocacy, activism are part of new Tigers coach Lombard's DNA - The Detroit News
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Significant Growth of DNA RNA Extraction Ki Market Will Grow at a Healthy CAGR by 2027 Along with Top Key Players Qiagen, Thermo Fisher Scientific,…
Posted: at 9:11 am
Understand the influence of COVID-19 on the DNA RNA Extraction Ki market with our analysts monitoring the situation across the globe.DNA RNA Extraction Ki market Analyasis 2021-2027
The DNA RNA Extraction Ki market report studies vital factors about the DNA RNA Extraction Ki that are essential to be understood by existing as well as latest market players. The report highlights the essential elements such as market share, profitability, production, sales, manufacturing, advertising, key market players, regional segmentation, and many more crucial aspects related to the Global DNA RNA Extraction Ki market.
Top Manufacturer Detail Qiagen, Thermo Fisher Scientific, Merck KGaA, Roche, Cytiva, Agilent, Danaher, Promega, Bio-Rad, Bioneer, Akonni Biosystems
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Section (5 6 7): Product Type SegmentationDNA Extraction Kit, RNA Extraction Kit
Industry SegmentationHospital, Laboratory, Other
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1.Gives a thorough analysis of the key strategies with focus on the corporate structure, R&D methods, localization strategies, production capabilities, sales and performance in various companies.2.Provides valuable insights of the product portfolio, including product planning, development and positioning.3.Analyses the role of key DNA RNA Extraction Ki market players and their partnerships, mergers and acquisitions.
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Significant Growth of DNA RNA Extraction Ki Market Will Grow at a Healthy CAGR by 2027 Along with Top Key Players Qiagen, Thermo Fisher Scientific,...
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DNA Repair Drugs Market: Rise in prevalence of cancer among population is likely to fuel the growth of the market – BioSpace
Posted: at 9:11 am
DNA Repair Drugs Market: Introduction
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Key Drivers and Opportunities of Global DNA Repair Drugs Market
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North America to Capture Major Share of Global DNA Repair Drugs Market
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Key Players Operating in Global DNA Repair Drugs Market
The global DNA repair drugs market is highly concentrated due to the presence of key players. A large number of manufacturers hold major share in their respective regions. Demand for technologically advaced products has increased in emerging as well as developed markets, owing to rise in prevalence of cancer. Growth strategies adopted by leading players are likely to drive the global market.
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Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through ad hoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories.
TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key to help enterprises reach right decision.
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DNA Repair Drugs Market: Rise in prevalence of cancer among population is likely to fuel the growth of the market - BioSpace
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Timothy Propes lived 43 years thinking his father died before he was born. A DNA test proved he was wrong – Gainesville Sun
Posted: at 9:11 am
John Henderson|The Gainesville Sun
For more than 40 years, Timothy Propes didnt know he had a father, as his mother told him he had died before Propes was born.
But over the years, he yearned to know more about his other family members.
He never knew that a DNA test would result in him finding out that his father was actually alive and livesonly an hour away from his Gainesville home, but also that he also had four sisters.
Honestly, I was still under the impression that my father had passed away before I was born, so I was hoping that I could possibly find some aunts or uncles, some relatives, the 43-year-old Propes said.
Propes and his wife decided to try out the genetic testing firm, 23andMe, which discovered that he had an aunt who was a blood relative who lived in Orlando.
He said he wasnt that excited at first, as aunts and uncles are popular relatives, not thinking that if the woman was in fact his aunt, that her brother would have been his father.
He tried reachingout to her by friending her on Facebook, but she didnt initially accept his request.
After six months, he decided to try and friend his aunts husband on Facebook to relay the message to her.
I sent him a request and he fortunately accepted it without knowing who I was, Propes said.
The man then relayed the message to his aunt.
When he accepted it, I sent him this letter explaining that, I was linked to your wife. We are relatives. She came back as my aunt.Id really like to talk to her, Propes said. And then she accepted my request.
They talked on the phone, and initially, his aunt was skeptical that her brother was his father, Propes said.
But after seeing his picture, the aunt then realized not only that Propes was her brothers son. She also knew which of her two brothers was his father.
As soon as she saw my picture, shes like, 'Oh crap, (what a resemblance), Propes said.
The aunt did not want to comment for this story, nor did Propes' father.
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Propes, who has his own children and works for Lake Butler Reception & Medical Center correctional facility, said his mother, who is no longer alive, gave birth to him at the young age of 14.
He was raised by his grandparents.
My grandparents actually adopted me because she was only 15 and she couldnt really raise me, he said. I always kept in contact with my mom. Id see her during the summer time.
Over the years, he didnt question his mom about his father as he thought he was dead.
The man she thought was my father, she thought he had died when she was pregnant, Propes said. And she really didnt talk about him too much. I didnt have anything to go by, not even the name of the man she thought it was.
But as the years passed, he yearned to learn more about the rest of his extended family, as it seemed like he just knew about his immediate family.
As I got older, curiosity kind of got the best of me, especially when I started having a family of my own, Propes said. I just kind of wanted to know a little bit about my biological history and things of that nature.
Inspiration: In a pandemic year, blind runner finishes 2,020-mile '2020 Challenge'
Propes said a couple of days after finally talking to his aunt, his father called him.
He learned that he lived in Green Cove Springs outside Jacksonville, about an hour drive from his home in Gainesville. It's also where Propes grew up.
We spoke for the first time, which went really well, Propes said. He was actually a lot calmer than Id thought hed be in that situation. We just kind of talked a little bit about my mom and the past.
In late March, Prope's father took a genetic test through23andMe, which confirmed thathe was his biological father.
He sent me a message with a screenshot of the results, Propes said. He just said, Welcome to the family, my long-lost son.
Propes said his father wanted to wait until April Fools Day to announce to his four daughters sisters Prope never knew he had that a son was also part ofthe family.
He wanted to play a prank on his daughters, Prope said. He had a little fun with it. We found out at the end of March so it wasnt too long before the family knew about it.
Propes then drove up to Green Cove Springs and met his father.
They hugged.
It was exciting, emotional, just a lot of feelings, Propes said. My wife has it on video. He was just walking out from his pier. He lives right on the water there in Green Cove Springs. We met in the front yard. We embraced. It was just surreal I guess you could say.
Tina Pearce, who also lives in the Jacksonville area, learned that Prope was her brother from the experience and has visited him several times at her fathers house.
It was kind of surreal because when my dad told us, it was on April Fools Day, so we thought he was just playing a prank, Pearce said. When we started looking at pictures it was just amazing how much he looked like our family. It was just crazy.
She said she wasnt there when her father first met Propes but she saw a video of it.
He was just kind of shocked and surprised, Pearce said. I dont think he had any idea.
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Timothy Propes lived 43 years thinking his father died before he was born. A DNA test proved he was wrong - Gainesville Sun
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Viral Vector & Plasmid DNA Manufacturing Market Research Report by Type, by Indication, by Workflow, by Application, by End User – Global Forecast…
Posted: at 9:11 am
New York, Jan. 13, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Viral Vector & Plasmid DNA Manufacturing Market Research Report by Type, by Indication, by Workflow, by Application, by End User - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p06007650/?utm_source=GNW
Market Statistics:The report provides market sizing and forecast across five major currencies - USD, EUR GBP, JPY, and AUD. This helps organization leaders make better decisions when currency exchange data is readily available.
1. The Global Viral Vector & Plasmid DNA Manufacturing Market is expected to grow from USD 688.42 Million in 2020 to USD 2,103.32 Million by the end of 2025.2. The Global Viral Vector & Plasmid DNA Manufacturing Market is expected to grow from EUR 603.62 Million in 2020 to EUR 1,844.23 Million by the end of 2025.3. The Global Viral Vector & Plasmid DNA Manufacturing Market is expected to grow from GBP 536.62 Million in 2020 to GBP 1,639.53 Million by the end of 2025.4. The Global Viral Vector & Plasmid DNA Manufacturing Market is expected to grow from JPY 73,472.92 Million in 2020 to JPY 224,478.60 Million by the end of 2025.5. The Global Viral Vector & Plasmid DNA Manufacturing Market is expected to grow from AUD 999.69 Million in 2020 to AUD 3,054.31 Million by the end of 2025.
Market Segmentation & Coverage:This research report categorizes the Viral Vector & Plasmid DNA Manufacturing to forecast the revenues and analyze the trends in each of the following sub-markets:
"The Adeno-Associated Virus is projected to witness the highest growth during the forecast period"
Based on Type, the Viral Vector & Plasmid DNA Manufacturing Market studied across Adeno-Associated Virus, Adenovirus, Lentivirus, and Plasmid DNA. The Lentivirus commanded the largest size in the Viral Vector & Plasmid DNA Manufacturing Market in 2020. On the other hand, the Adeno-Associated Virus is expected to grow at the fastest CAGR during the forecast period.
"The Infectious Disease is projected to witness the highest growth during the forecast period"
Based on Indication, the Viral Vector & Plasmid DNA Manufacturing Market studied across Cancer, Genetic Disorder, and Infectious Disease. The Cancer commanded the largest size in the Viral Vector & Plasmid DNA Manufacturing Market in 2020. On the other hand, the Infectious Disease is expected to grow at the fastest CAGR during the forecast period.
"The Upstream Processing is projected to witness the highest growth during the forecast period"
Based on Workflow, the Viral Vector & Plasmid DNA Manufacturing Market studied across Downstream Processing and Upstream Processing. The Downstream Processing further studied across Fill-finish and Purification. The Upstream Processing further studied across Vector Amplification & Expansion and Vector Recovery/Harvesting. The Downstream Processing commanded the largest size in the Viral Vector & Plasmid DNA Manufacturing Market in 2020. On the other hand, the Upstream Processing is expected to grow at the fastest CAGR during the forecast period.
"The Vaccinology is projected to witness the highest growth during the forecast period"
Based on Application, the Viral Vector & Plasmid DNA Manufacturing Market studied across Antisense & RNAi, Cell Therapy, Gene Therapy, and Vaccinology. The Gene Therapy commanded the largest size in the Viral Vector & Plasmid DNA Manufacturing Market in 2020. On the other hand, the Vaccinology is expected to grow at the fastest CAGR during the forecast period.
"The Research Institutes is projected to witness the highest growth during the forecast period"
Based on End User, the Viral Vector & Plasmid DNA Manufacturing Market studied across Biotech Companies and Research Institutes. The Biotech Companies commanded the largest size in the Viral Vector & Plasmid DNA Manufacturing Market in 2020. On the other hand, the Research Institutes is expected to grow at the fastest CAGR during the forecast period.
"The Asia-Pacific is projected to witness the highest growth during the forecast period"
Based on Geography, the Viral Vector & Plasmid DNA Manufacturing Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom. The Americas commanded the largest size in the Viral Vector & Plasmid DNA Manufacturing Market in 2020. On the other hand, the Asia-Pacific is expected to grow at the fastest CAGR during the forecast period.
Company Usability Profiles:The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Viral Vector & Plasmid DNA Manufacturing Market including ABL Inc., Batavia Biosciences B.V., BioNTech IMFS GmbH, Biovian Oy, c-LEcta GmbH, Cell and Gene Therapy Catapult, Cevec Pharmaceuticals GmbH, Cobra Biologics Limited, Creative Biogene, FinVector Vision Therapies, FUJIFILM Diosynth Biotechnologies Inc., GE Healthcare, GeneOne Life Science, Inc., Genezen Laboratories, Kaneka Eurogentec S.A., Lonza Group AG, Merck KGaA, Miltenyi Biotec GmbH, Novasep Inc., Sirion-Biotech GmbH, Spark Therapeutics Inc., Thermo Fisher Scientific Inc., uniQure N.V., Vigene Biosciences, Inc., and Wuxi AppTec Co., Ltd..
Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.
360iResearch FPNV Positioning Matrix:The 360iResearch FPNV Positioning Matrix evaluates and categorizes the vendors in the Viral Vector & Plasmid DNA Manufacturing Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.
360iResearch Competitive Strategic Window:The 360iResearch Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The 360iResearch Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.
The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments
The report answers questions such as:1. What is the market size and forecast of the Global Viral Vector & Plasmid DNA Manufacturing Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Viral Vector & Plasmid DNA Manufacturing Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Viral Vector & Plasmid DNA Manufacturing Market?4. What is the competitive strategic window for opportunities in the Global Viral Vector & Plasmid DNA Manufacturing Market?5. What are the technology trends and regulatory frameworks in the Global Viral Vector & Plasmid DNA Manufacturing Market?6. What are the modes and strategic moves considered suitable for entering the Global Viral Vector & Plasmid DNA Manufacturing Market?Read the full report: https://www.reportlinker.com/p06007650/?utm_source=GNW
About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.
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Viral Vector & Plasmid DNA Manufacturing Market Research Report by Type, by Indication, by Workflow, by Application, by End User - Global Forecast...
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DNA Special: Are OTT platforms abusing right to expression? – DNA India
Posted: at 9:11 am
In today's show, we will tell you how the guidelines applied to news channels over news coverage doesn't apply to OTT platforms and digital media, which affects the youth. News Broadcasting Standards Authority (NBSA) is an independent nine-member body set up by the News Broadcasters Association (NBA) for the self-regulation of 24X7 news channels that are part of NBA. The body issues guidelines for covering sensitive news from time to time, which the news channels have to follow.
For example, channels cannot show an interview of a terrorist, pictures of dead bodies, blood. In serious cases, the victim's identity is not disclosed.
This set of guidelines apply to all news channels, but no such rules are applicable to OTT platforms and digital media and that is why the viewers get to see and hear a lot of violence and abuses in online content. This in turn negatively affects the youth and children.
It has become important to decode this unlimited freedom of OTT platforms. First of all, we will tell you what is meant by the term 'OTT platforms'. OTT means Over The Top. When the content of films and television is made available to viewers through the Internet without any cable network and satellite channel, it is called OTT.
The basis of this analysis is a Web Series released on 15 January 'Tandav'. In this Web Series, there are allegations of humiliating Hindu deities. And the important thing is all this has happened in the name of freedom of expression. Imagine the freedom to express ideas, which is called the right to expression, how it transcends boundaries and justifies the insult of Hindu deities. It is said that this is an art and this art should be valued.
Many people are angry because of this, but a big thing here is that there was no riot in India. It can be said that in our country, it has become very easy to insult Hindu deities and the producer and director of this web series have been accused of similar.
This new web series has presented a very negative image of the country. The character of the country's politician, hospital, school, police, university, administration, government, the prime minister is shown in such a way that you will lose your trust and confidence in the system. It has been shown that nothing good is happening in our country. In the series, a narrative has been portrayed by linking the names of characters to a particular religion which presents the wrong image of the country to the world.
However, a dispute has now arisen and an FIR has also been filed in Lucknow and people are demanding action against the producers and directors of this web series.
The News Broadcasting Standards Authority, or NBSA, is the organisation that regulates the content currently shown on news channels in India. There is the Press Council of India to regulate print media. For films, there is the Central Board of Film Certification which is called censor board. But there is no such organization to control the content on digital media and OTT platforms.
Censorship and regulation are two different things. Censorship is modesty and regulation an arrangement. There should be regulations for OTT platforms and digital media as well, because when the expression in the society gets molded in the form of speaking, writing and showing, then the biggest danger to this expression is democracy itself. It becomes a power over which no one has control.
The films and web series shown in the name of freedom of expression are starting to take the course of abuses and vulgarity. You may have inadvertently submitted a membership fee on many online streaming platforms to do this course. And we are confident that these streaming platforms will be streaming negative thoughts in your mind by misusing your time and money. Therefore, we want you to take a pledge to delete these thoughts from today.
Earlier, the films used to go from shooting to screening in a long reel, which was delivered to theaters in a box. That hundred of feet long reel was mechanically rotated, through which a bright light used to go on the screen and the scenes that were produced from that light were seen in those iconic films of Bollywood.
This journey started with Doordarshan, through which information and many TV serials reached people.
One of the serials was 'Hum Paanch', which was based on the story of India's middle-class families. Similarly, serials like 'Wagle Ki Duniya', 'Malgudi Days', 'Yatra' and 'Mungeri Lal Ke Haseen Sapne' became very popular.
The Zee TV entered the industry after the entry of private satellite channels in India. In 1993, a serial was aired on ZEE TV, titled 'Tara'. It was a clean serial with no vulgarity of any kind. There were no abuses. Then also the serial became quite a hit in India. Apart from this, there came serials like 'Jeena Isi Ka Naam Hai', 'Rajni', 'Sa Re Ga Ma Pa' and 'Kaun Banega Crorepati', which created a different identity among the people.
And now this journey has reached OTT platforms, where vulgarity and abuses are treated as a test of success. Where it is believed that the more abuses, the greater the chance of getting success.
According to a study, while watching movies and web series on OTT platforms, the attention of people changes every 8 seconds. And in such a situation, abuses and obscenity are put into films to keep these people tied with them. This means, by taking money from you, some people decide how much abuses and vulgarity they have to sell.
It is quite easy to trade negative thoughts in India. Negative thoughts are easily valued in our country. And many companies make crores of rupees by selling them. But all this does not happen with the government's money. Trading negative thoughts become a profitable deal with your money.
In the year 1994, a film 'Hum Aapke Hain Koun' was released, in which, weddings with Indian customs and traditions were shown as an event. It is said that due to this film, the mentality of the people also changed and wedding business became a big market in India.
Now a similar hit formula is also being worked on OTT platforms. The formula is to offend religious sentiments, add as much vulgarity to the story, glamorize abuses in the name of dialogues and connect the whole story around a negative character.
However, we feel that OTT Platforms also have some powers which can become a very effective platform if the designer is free of ideas. So today we want to tell you some strong aspects of this as well.
First, OTT platforms have brought a new freshness to stories. A new style of telling and showing films has been born. New artists and writers have got the chance to present on the stage. And most importantly, because of this platform, a 10-hour long web series has been created, which probably no one had even imagined.
There was a time when it was said that the duration of films should be three hours. But in this era of web series, the theory of 'The End' is now over.
In India, it was announced recently that the control of all the OTT platforms will now be with the Ministry of Information and Broadcasting, Government of India. The President of the country has also signed this notification and now the government keeps a close watch on whatever content you see online. A few days ago the government also made it clear in the Supreme Court that before controlling the news channels, digital media needs to be controlled.
OTT service providers' accountability regarding content should be fixed. And to do this, the government has to make new laws and regulations. The government will have to ensure that when a complaint is made about any content of the OTT platform, then action should be taken in due time.
However, Ali Abbas has apologized after the controversy on the web series Tandav. He has shared his apology on Twitter. He has written that "the cast and crew did not have any intention to offend the sentiments of any individual, caste, community, race, religion or religious beliefs."
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DNA Special: Are OTT platforms abusing right to expression? - DNA India
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Living with Death: A Podcast with BJ Miller – GeriPal – A Geriatrics and Palliative Care Blog
Posted: at 9:01 am
Most of us know we are going to die. How often though do we actually let ourselves really internalize that understanding? To imagine it? To feel it? To try to accept it?
On todays podcast we invited BJ Miller back on our podcast to talk about death using as our guide his recent NY Times editorial What Is Death? How the pandemic is changing our understanding of mortality.In addition to being the author of this NY Times article, BJ is a Hospice and Palliative Care doc, and the founder of Mettle Health which aims to provide personalized, holistic consultations for any patient, caregiver or clinician who need help navigating the practical, emotional and existential issues that come with serious illness and disability.
We start off with BJ appropriately picking the song "Ebony Eyes" as our intro song, which is a good analogy to talking about death, as it was initially banned by the BBC from airplay as its lyrics were considered too upsetting to play on the radio. We then go into his thoughts on how we picture our deaths and dealing with those emotions we feel when we do, how we live with death, and
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TRANSCRIPT
Alex: This is Alex Smith.
Alex: And today we're delighted to welcome back BJ Miller, who a hospice and palliative care doc, and co-author of Beginner's Guide to the End. We had a podcast about that previously, we'll link to that in the show notes affiliated with this podcast, and also the founder of Mettle Health and author of a opinion piece in the New York Times that came out in December about death that we're going to talk about today.
Eric: Before we get into that topic, BJ, again we'll have links to that New York Times article What Is Death? How Is the Pandemic Changing Our Understanding of Mortality, big topic, but we always start off with a song request. Do you have a song request for Alex?
BJ: I sure do. This is my favorite part of you guys' show. Ebony Eyes by the Everly Brothers.
Alex: And why this choice?
BJ: Well, I mean, those of you who don't know the song, you'll see. It's just a lovely, sweet little lullaby that has a pretty devastating end to it. And it touches on our theme of the day.
Alex: It does.
BJ: And I just love the Everlys.
Alex: Yeah. I did a little Googling. I was not familiar with this song, and it's in 3/4, which is unusual, it's got this beautiful beginning lullaby story that I'll play at the beginning, and then we'll get to the devastating ending at the end. But it just is so emotionally manipulative and wrenching that it's almost humorous in that it's just right in your face in the way that it does it. It came out in 1961, made it to the top 10 in the charts. It was banned by the BBC because they worried it would make people too sad to listen to.
BJ: I didn't realize that. Hilarious. Thank you.
Alex: (singing)
Eric: Uh-oh. Foreshadowing makes me worried.
BJ: You should be, Eric. That was beautiful, man. That was beautiful.
Eric: So BJ this podcast and maybe banned because it may because severe sadness amongst all of our listeners, because we're going to be talking about death. We can talk about puppies and kitties instead if you'd like. [laughter]
BJ: No. I was going to make a horrible joke about that, no. But we'll do it. We'll dive in. We'll go ahead and we'll do what our patients have to do.
Eric: All right. Can I just ask, before we get into this topic, when we think about other people's death, that's like, okay, we can't handle that emotionally, but for a lot of us, when we think about our own personal mortality and death, maybe our heart starts to flutter. We feel that deep pit, our stomachs are churning.
Eric: Obviously you wrote this piece and I'd love to hear why you wrote this piece, but do you still get that inner feeling of dread when you think about death, or how have you handled that?
BJ: It hasn't changed much. I watch my mind begin to try to picture it, I picture my corpse, I picture a lifeless body, I picture the world without me running around in it, but of course that's where I started short-circuiting, because when I picture the world without me running around it, I'm still picturing it through my eyes. I'm still picturing it as I know it. And that stops.
BJ: It's almost like I feel myself short circuit, so I can approach it, I can get close, but ultimately I really struggle to actually get all the way there. I don't know if we can get all the way there, but it does seem to be some utility in trying to get as close as you can, to narrow the distance between you and this thing that can get so scary.
Alex: Mm-hmm (affirmative). So, you've been thinking about death for a great deal of your life. And as you've talked about in your book and in your Ted talk, you had an experience of coming close to death in your late teens, early twenties?
BJ: Yeah. 19. Yup.
Alex: 19. And so you've been thinking about death for much of your life. I wonder if you could tell us how your thinking about death has evolved over time.
BJ: Yeah. Well, in some ways it hasn't. In some ways it remains as ultimately, it's penetrable to a point and I can't quite get past to the point. So what's happened over time, and what has felt, and it feels therapeutic for me and has attenuated my fear, is that the process of imagining my own death, trying to internalize it, trying to make it real, because it is real, and therefore me trying to come to terms with reality, which is ultimately my personal goal, I want to know reality and I want to be okay with it, where I get my, like I was saying earlier, I ping off it, I could watch my brain deflect off it eventually.
BJ: But I deflect to a place where I imagine other people, I imagine the world ... like right now, one of the ways I picture my death is not so much me picturing me dead, it's picture things happening in the world without me in it. So just picturing your lives is almost a practice. My friends, if I think about my friends, what they're doing right now without me in the room ... in a way, thinking about my own death has hope is that it puts me in touch with the world beyond myself. And that seems to be so much of its therapeutic value. That's where the humility is, that's where the right-sizing is, that's where the realization is that yeah, my ego will die, this body per se, on some level will die, but life keeps going. Life keeps going. That's what this misnomer of end of life. No, no end of your life, end of my life, but even that's a porous thing.
BJ: So over time, to answer your question, Alex, it has evolved to allow me to see the world outside of myself. And that seems pretty important.
Eric: And I really loved your New York Times piece, because it starts to talking about how this pandemic is changing a little bit about how we're thinking about death. I was wondering, would you be willing to read the first maybe paragraph or two of the New York Times piece?
BJ: Yeah. I'd be happy to. I'll pull it up. So, let's see here. "This year has awakened us to the fact that we die. We've always known it to be true in a technical sense, but a pandemic demands that we internalize this understanding. It's one thing to acknowledge the death of others, and another to accept our own. It's not just emotionally taxing; it is difficult even to conceive. To do this means to imagine it, reckon with it, and most important, personalize it. Your life. Your death.
BJ: "COVID-19's daily deaths and hospitalization tallies read like ticker tape or the weather report. This week, the death toll passed 300,000 in the US. Worldwide, it's more than 1.6 million. The cumulative effect is shock fatigue or numbness, but instead of turning away, we need to fold death into our lives. We really have only two choices: to share life with death, or to be robbed by death."
Alex: As you've talked about here and in your piece, you have this focus on trying to imagine what it's like to be death and trying to grapple with and understand what it means to be alive and then to die. And I'm wondering if you're suggesting, and also for you, personally, is, do you have a regular practice of thinking about death? Is this almost ritualized in some way for you, in terms of something that you come back to with regularity?
BJ: There are certain death meditation's, more formalized traditions around this sort of practice. I don't have a practice per se. I guess I'm trying to be integrated in a way, for my own personal development. So it's not like I'm one way at work and another way here, and I have my formal meditation hours and the rest of time I'm letting my brain run me around the planet. For me, it's all much more mushy and vague. And so I think about my death throughout the day in multiple ways, but not as a practice and not in a formal way, it's just a sweet little reminder. And I think of it any time I see a bug in my windshield, or when I see the death tally, I try to remember these were actual people, and [crosstalk 00:10:55] plant myself into that math.
BJ: But in answer to your question about, no, I don't have a formal practice, but in a way I do it all day long, every day. And it's gotten to the point where there's a relief too. I feel some relief, too. I use it ... Sorry, Eric. I'm just going to say I also use this when I get anxious about all the things I'm doing wrong or not doing right, and I also let death be a comfortable thought, like, "Someday, I won't have to worry about these things." And when I get down on myself for not getting to everything on my list, I realize that's part of the practice, also, of death and dying, is you're not going to get to everything that you've dreamed of. In a way, that's a good thing. My dreams exceed my reality my life's boundaries. And I have come to like that tension.
Eric: And when you talk about sharing life with death, is that what you mean?
BJ: Yeah, yes. That I think the goal is death from a design view or from a worldview, from an integrated view, is if we can actually rope death into our frame of life, versus the thing that robs us of life, that takes our life, this pernicious force that comes in and sneaks in and snatches us away.
BJ: That's terrifying. And I think it's just more accurate to say that death is part of life, that death frames a life. And like we were saying earlier, my life ends, but life keeps going, and in some ways my body goes on to be other things. Death gets hard to say that it actually exists. Certainly exists in my ego. The death of BJ will happen. I don't doubt that. But if I can normalize that, see myself in the world that accommodates that fact, then I'm going to be less at odds with nature, less at odds with reality and less at odds with myself. And that's very appealing.
Alex: You talk in this piece about how the cells in our body are continually dying and turning over. And when we die, the cells in our bodies will turn over and become other things as well. The carbon molecules will become parts of plants and parts of other aspects of nature. And it struck me as I was reading, that this is like a scientific, spiritual conception of life and death. And so I wanted to ask you about your own spiritual religious beliefs or framework. Where are you coming from?
Eric: I also love seeing that big oak tree right behind you as we're talking about what happens to the atoms of ourselves when we die.
BJ: Yeah. Yeah. I love this tree, this big live oak, and it actually may be dying. I recently had someone look at it. It may be slowly dying and I guess, okay, so we are.
Eric: What really is death, BJ?
BJ: Exactly. As you were describing that, Alex, as you were describing that passage, as I listened to you describe it, I'm tempted to go, "Wow, that sounds spiritual," or, "that sounds fantastical or something, or it sounds poetic, even," but no, that actually just is. You just described observable science. Nature is pretty poetic all by herself. That's part of the fun realization, is that when you start paying attention, it is everywhere: in you, on you, around you, death and life, completely just turning, ever churning.
BJ: So, I don't wish that to be or not wish I had be. That just is. I mean, again, that's observational science. I mean, the point about atoms, I guess that starts getting theoretical. You have to believe that there was a Big Bang theory. You have to believe in the Big Bang theory to set off this cascade of action. And that has set us a finite number of atoms in the universe and these atoms keep coalescing and decaying, coalesce, decay, that's happening all the time.
BJ: So, that's the only piece that asks for a little leap of faith that is somewhat theoretical, but otherwise we're just talking about the things you can observe. So, I don't think of it as so spiritual per se, but then again I do, because I guess the point here is separation, separating life from death, separating each other from one another ... this is where we get into trouble, separating spirituality from science. That's so much of our problem, is siloing these things when in fact they're different ways of describing so much the same thing. So that's my answer your question, that's my spiritual bent, is to keep looking for the limitations of language versus the limitations of reality, the limitations of myself versus the limitation of life writ large.
BJ: Now, I'm trying to find these false distinction, these false dichotomies and these false separations, so that I don't feel so separate from, or other than, et cetera, because I think that's where all the trouble creeps into human endeavor.
Eric: Well, it's really fascinating. That one paragraph ... So you talk about from the time you're born and your body's turning over, cells are dying and growing every day. So, data driven start of that sentence, but it ends that paragraph with a story. It's a metaphor. It's poetry. A vital tension holds you together until the truce is broken. So we're now using metaphors to help us understand the data.
BJ: Yeah. And like we were saying earlier, sorry to interrupt you, Eric. I mean, I think we're only left with metaphor. It's like asking us to picture our own death. You can only talk around it. It's like describing a hole or a negative or a vortex. You can define it in the negative space around it.
BJ: Similarly, metaphor may be as close as we can get to a literal truth. I don't know if that sounds ironic, but yeah, I think this is the power of metaphor and why we need it and why we need the expressive arts to even begin to get closer to our subject matter.
Alex: I'm just reading through ... you end this section, "But we have fuller ways of knowing. Who doubts that imagination and intuition and love hold power and capacity beyond what language can describe? You are a person with consciousness and emotions and ties. You live on in those you've touched, in hearts and minds. Just remember those who've died before you. There's your immortality. There, in you, they live. Maybe this force wanes over time, but it is never nothing."
Alex: It is interesting to move from this scientific conception of the cells moving over into time, into parts that are still unknown and unexplained in terms of science. What is consciousness, right? What gives us the ability to be conscious? This is at that liminal border between spirituality and science. We haven't gotten there with science; we can't explain it, yet. There may come a day, but we have to rely on something more in order to integrate our understanding, and also to integrate our understanding of our relationship to others. And I love that line that you live on in others in different ways when you touch them, also with the love that they experienced for you, and they carry that with them, their memories of you, but also in terms of just the cells that you transmit to other people, and that turnover become other people over time.
BJ: Yeah. Isn't it cool? It's just really amazing. And I think that's part of the practice, too, is part of the fun of being reminded that these things can be scary putting yourself in perspective like this, but it's so dang interesting. It's so fascinating. It's so dang amazing. And I think that's another reason why I'm interested in pulling attention to the subject, is not to be a downer or to be ... but because it's actually fascinating and in a way beautiful and beyond our comprehension.
Alex: I was also struck reading this and wondering, do you have mentors or spiritual advisors, or are there people who you read in particular who have influenced your thinking about death strongly?
BJ: No, I don't have a mentor per se or a pathway per se, because for me, the pathway is a self discovery. I mean, received wisdom, received knowledge is important, and I don't want to shirk it, but I also know that I don't want to fall in a pit of actually memorizing lines or memorizing other people's ideas to help me understand myself.
BJ: So, yeah, I might draw from the existentialists, Heidegger, Kierkegaard, Nietzsche, these guys have been helpful to me. Working at Zen Hospice and just thinking about Buddhism is of interest to me. I grew up in the Episcopalian tradition, and that informed a lot of my early thinking around death.
BJ: So, yeah, sure. I mean, eclectically, I'm hearing and reading to some degree these thoughts and ideas of others, but that just helped me get in the ballpark. The rest, it feels important and it is. I don't want to over read other people. It needs to be self-evident, because we're talking about a process that is going to happen to me and my relationship to it. And I think that's what's so important. So, yes, respecting traditions that have gone before, but really ultimately, I need to figure that stuff out myself.
BJ: So my main teacher is daily life. And it's born of this notion that Monday through Saturday should be just as amazing and fascinating, and God, whoever, whatever that is, should be palpable in a strip mall as much as in a church. And so, similarly, I feel like I have to be able to live these things. And even if I'm discovering things a zillion other people have discovered before me, that's okay. This way I can own it in my gut, in my viscera.
BJ: So daily life as my teacher. Reconciling my own feelings about my own losses, my own inadequacies, that's stuff comes up every day, and those are proxies for death meditations to some degree.
Eric: And how has the pandemic changed anything for you or have you seen it change for other people, how they think about death or life?
BJ: You asked why I wrote that article, Eric. I mean, it's a little bit because ... Well, for one, I mean the skeleton of that article, interestingly or whatever, was a book chapter in Beginner's Guide to the End that I wrote for that book, but the publisher cut it. It wasn't practical enough or something for the publisher. So they cut that chapter. I loved that chapter. For me, it's where so much of the interest is.
BJ: So I'd always been looking, wondering what I could do with that. So that was the background, but then the pandemic, the overlay now is that this existential crises that have been personal for me personally, my own life or with our patients, and we deal with people in existential crises all the time. And we watch folks at the individual level or the family level confront their own fears, either by choice or by force, and you see transformations happening, you see expansions happening. And so we get these little sweet little vicarious things all the time through our patients and families.
BJ: And so just has struck me that what's happening now with the pandemic is that's happening at scale. We are having a massive shared existential crisis. And that's terrifying, because existential crisis are terrifying, but we know existential crisis. They have just felt like a secret. You almost wish to have an existential crisis, have an excuse to think and feel about these things, because it's vital. So, I guess the point here is I feel an opportunity right now, because normally, that transformation happens quietly, knowing it's not shared. One of the hard parts about existential crisis is that very often it makes people feel very alone.
BJ: Well, here we are having the potential to have all sorts of realizations with an existential crisis, but in a shared way. And then in fact, this could bring new levels of community, new levels of empathy, new levels of shared experience, and can right-size us as a people.
BJ: So I feel this great potential, based on what we see with our patients and families for that to happen in a public way. And so the reason to try to get this into the public discourse was to try to begin helping to catalyze the realizations that happen when you dare to look at something that you're afraid of.
Alex: Yeah. And as you started off the piece, it can be so easy to become inured to death, and it's just another number, as you say, like a ticker tape on the stock market, numbers up, numbers up, numbers up again. But who are these people? And it's so personal for so many people who have lost their loved ones, who've cared for loved ones who have died. I mean, I think we've all cared for people who've died of COVID in our work in palliative care and hospice.
Alex: And that brings us to an experience that you talk about with a patient who, it sounds like she has cancer, advanced cancer, and she talks about how COVID is changed her friends' perspective and that she seems able to relate to them more because of the tremendous uncertainty about what's going to happen to all of us and confronting our own mortality. I wonder if you could say more about that experience in that patient encounter.
BJ: Yeah. Well, so, I'm going to change her name. I'll call her Tina. So, the experience that happened with Tina was on a Zoom visit like we're talking, and she's a ... the word I should use really is client now, because in Mettle Health, I'm not doing the medical piece, it's all the nonmedical stuff that I'm wading into with folks. So she's a client. And we were just talking about her own experience and how she was noticing what used to feel so ... She's beloved, students, friends love her, she's surrounded by, but there's an unbridgeable divide oftentimes with folks when it comes to really the personal vulnerability of being frail or dying. And there's some of that piece that the patient really just often ends up having to walk alone. And maybe ultimately there's always a piece that they have to walk alone.
BJ: But the aloneness is so much often the problem. I don't know about you guys, but so often in clinic ... many of the things, but when you get down to it, the person just feels so alone, so unseen and unwitnessed, and as though they don't exist. I've had this feeling myself, the feeling of being in saran wrap. People can see you, you can see them, but there's something that gets in the way that you're just not quite totally reachable.
BJ: And we were talking about that phenomenon and she was just reflecting, almost in this embarrassed way, embarrassed to say it out loud, because celebrating a pandemic seems kind of crazy. But as we know, this is where language gets screwy. So many of our patients, they're not going to be like, "Hey, I love cancer." But in their most honest moments, they will share with us all they've learned from their cancer and they wouldn't have learned it otherwise.
BJ: So it goes with this, in this hush whispered tone, where she was just realizing as we were talking that she felt less alone, less unseen, more seen. And it wasn't that people were saying different things to her, but they were just holding eye contact a little bit longer, there was a little bit more shared silence, there was a vibe. A vibe, that's the best way to put it, that they could share, where she felt just a little bit more seen, just a little bit more heard.
BJ: Anyway, it's just a telling, sweet, sweet moment. And as it goes, like in our work, our goal would be to root out suffering, as it's not possible as we know, ultimately, but even if it were possible, can you imagine what Stooges we be if we all ... The learning that comes from our suffering and from the things that we can't control is profound and not to be dismissed. And I would be very careful of trying to root out all suffering, because we root out a lot of learning, too.
BJ: It's a moot point because we can't rule out all this suffering. But anyway, I'm going round and round in circles here, but somewhere in this mix of trying to find language to respect what pain and suffering and things outside of our control teach us and do for us, without somehow wanting or courting or celebrating the pain itself or overly attaching to that pain. I find it very tricky to describe, but that look on Tina's face when she leaned into the computer was unmistakable. There was a sweet little wink in her face that I hadn't seen before. And it was all thanks to this shared pain.
Eric: You brought up the word "crisis." I'm actually reading a book by Jared Diamond called Upheaval and it talks about nations in crisis ... It's a really good book for anybody who wants to read it. But basically, another way to think about a crisis, it's a decisive point. And it can go either way, and while there is this potentially fleeting sense that we have that it's recognizing our own mortality, do you think it's just going to be fleeting, that it's just going to go away and we return to the usual? And like for your patient that you were describing, will it go back to just people trying their best to ignore the fact that, including myself, that we're mortal beings, and it's so much nicer to think about something else?
BJ: Yeah. Well, I hope not. I'm glad you asked that, brother. I mean, this is my big wondering right now personally. Are we just going to snap back? It's almost like the financial crisis in 2008. It was such an excuse to learn a bunch of stuff and change some things, but we just snapped so forcibly back right to where we were and clung to that old way even more tightly.
BJ: So the question have we suffered long enough has enough dripped from our control and have enough illusions reveal themselves as illusions for us to actually remember? I don't know. The jury's out. But that's another reason I wanted to write that piece. And I'm glad we're having this conversation and many others are too is to try to keep it in our field of view so that we don't forget.
BJ: And you said, something, Eric, which is a tell, get back to thinking about something that's more pleasant about than our own death. But even as we're talking, whether it's the Everly Brothers' music or own conversation or the poetry or metaphor, actually, there's something really beautiful about all these thoughts, too. And that's another thing I'm hoping that corner will turn, is that we don't really lose this reflexive sense that, gosh, we'd rather be thinking about anything else or talking about anything else, because with a little practice, I think actually we realize there are a few things that are more interesting or more amazing than what we're talking about, than actually facing the [crosstalk 00:31:58] end.
Eric: Yeah, it's fascinating, because I think about death all the time in my work. I'm a hospice and palliative care doctor. But it's other people's death. And when I think about my death, I still get that feeling inside me, like this is a dangerous place to be. I explore it, I explore around it, and when I no longer can take it, I'll think of something else. But I would say 10% of the time, it also makes me think take advantage of what we have today. The life around us is really amazing. All of those things I'm worried about, it really doesn't matter. And just hang out with the family, hang out with my friends. And it does bring some beauty to what we're all going through.
BJ: Yeah. It's so very interesting that this is coming along a pandemic, is coming along at around the time of social upheaval, of renewed calls or new calls for social justice. In a time where we're so divided, I think it's actually also another reason to put this stuff out in the world right now, is we might say, "Oh, we have so much in common as human beings, black, white, rich, poor ..." But even that stuff isn't so palpable right now. In fact, a lot of the divisions that separate us from each other, what's so palpable where so much of the focus is.
BJ: So I think it's also really important right now to name the things that we actually do share, that we actually do share, not just as a pleasant idea, and death being one of them. Not only being mortal, but as human being, having to know you die in advance of your death, I can't say enough about how tricky that is, and that itself is a bond between people.
BJ: So I think it's really important to name this actual shared space and to dwell in there and hang out in there before we go back to separating ourselves and distinguishing ourselves from one another.
BJ: Illusions, hey, illusions are fun. Just call a spade a spade. I think it's important that we let this moment take us down. Let the stuff fall. Let it take us down to the studs so that we can see what part of us isn't mutable, what doesn't change, and so that we can see all the stuff that actually turns out we can live without. And we can welcome luxuries back into our life, sure. But just call it a luxury. Don't call it a necessity. That little distinction is really potent. So we don't have to come out of this with the life of anesthetic and somehow of keeping ourselves from those pesky illusions, no. Illusions are fun and hilarious. Just call them an illusion, just call them temporary. That's all I'm asking.
Alex: And we're coming to the end here. I would love it if you could read the last three paragraph of this before we get there, because so much of your, as I told you before we started, the prose, your writing is terrific, BJ, and some of my favorite lines, I tweeted out one and then Rob Rossick tweeted out another, they were all from these last three paragraphs. I wonder if you could read those.
BJ: Yeah, that'd be my pleasure. And thank you, man. I really like hearing that from you, Alex in particular with that brain of yours. So let's see here.
BJ: "Beyond fear and isolation, maybe this is what the pandemic holds for us: the understanding that living in the face of death can set off a cascade of realization and appreciation. Death is the force that shows you what you love and urges you to revel in that love while the clock ticks. Reveling in love is one sure way to see through and beyond yourself to the wider world, where immortality lives. A pretty brilliant system, really, showing you who you are (limited) and all that you're a part of (vast). And as a connecting force, love makes a person much more resistant to obliteration.
BJ: "You might have to loosen your need to know what lies ahead. Rather than spend so much energy keeping pain at bay, you might want to suspend your judgment and let your body do what a body does. The past, present and future come together, as we sense they must, then death is a process of becoming.
BJ: "So, once more, what is death? If you're reading this, you still have time to respond. Since there's no known right answer, you can't get it wrong. You can even make your life the answer to the question."
Alex: It's great.
BJ: Not bad. [laughter]
Alex: Yeah. Oh, it's great. And it really is, as you started off, an encouragement to people to take this pandemic as a moment to remind us of death, and then incorporate that into our daily experiences, because death is around us all the time as you said earlier. A bug on the windshield is a reminder of death, and that we can take this opportunity to explore within ourselves what that means and to come to our own understanding of what it means to die, and to know that we will one day die, and how will that shape the way in which we live, the way in which we relate to others, the way in which we relate to the natural world? Yeah, I just have to say I love that.
Alex: What sort of reaction have you had from others, from patients to this piece in the New York Times?
BJ: It's been really sweet, I got to say, and it was fun to read the comments in the New York Times, because a lot of people were actually we're taking the charge, were answering the question for themselves. And that's really the hope here, is people ... So people were taking the bait. In a way it's the wrong word, but that was just lovely to see.
BJ: And then I've heard a lot from patients that they felt that they saw themselves in those words, and they saw something that they have felt put into words in ways that resonated, words that maybe they hadn't found yet. But that's my favorite compliment, I guess. People are telling me they could have written it if they had found the words. It described how they have felt in moments of clarity. And that's been really cool.
BJ: And that's been coming from patients and families. I mean, one of the tricks here is the subject is interesting. And if you're not careful, you can bring your intellect to it. But that's won't get you all the way there, and in some ways it's even hazardous. Eric, you mentioned something really important about us. One of, I think, the pitfalls of our work, guys, is we are around the subject a lot. So if we're not careful, we might fool ourselves into thinking, "Oh, we've got this. We understand what this subject ... I'm around it all the time. Patients are dying all the time around me. So therefore I got it."
BJ: Uh-uh (negative), not necessarily. It is a different corner to put ourselves into those shoes. And the hope here would be that this, for our field, that the potential here is to just a little bit narrow the gap between us and our patients and our families, and thereby make us even better at our jobs. But getting these few millimeters of being better at our jobs means we're going to have to get used to being uncomfortable ourselves.
Eric: Yeah. And I think, Alex said the concept of knowing that we're going to die, it's easy. I have that all the time. It doesn't bother me. Feeling like I'm going to die, that's the scary part, being willing to have that feeling and sit with that, we bring them to the word "suffering," and that there is suffering in that. And out of that can come a lot of beauty.
BJ: Amen, brother. Yep. And just one more ... I know where we're trying to wrap up, but I want to also make it clear, because there is a rapturous, exalted side of this very earthly thing. I just want to be careful, too, and just clarify, I can imagine someone hearing this and reading these things and feel like we're just putting lipstick on a pig or trying to somehow focus on the pretty parts. I don't think you guys are, but let's just be clear. The idea is to not polish this subject, but find beauty in the rough. So you've got to go through the hard feelings. This is not an effort to keep hard feelings at bay; it's to go into these hard feelings so that you can see that you're more than just these hard feelings and these hard feelings become fertilizer for other things.
BJ: So I don't want to beeline for the pretty stuff and short circuit the hard stuff. That would be an absolute mistake. The point here is to get into the world of the feeling of the viscera, and that kind of pain, that's where these next level lessons come.
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Living with Death: A Podcast with BJ Miller - GeriPal - A Geriatrics and Palliative Care Blog
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SpaceX will launch its 1st Starlink satellites of 2021 on Wednesday. Here’s how to watch. – Space.com
Posted: at 9:01 am
Editor's note: SpaceX has postponed the launch of its first Starlink mission of 2021 until Wednesday, Jan. 20, at 8:02 a.m. EST (1302 GMT) due to bad weather conditions at sea for its Falcon 9 rocket's landing.
Original story:
CAPE CANAVERAL, Fla. SpaceX will launch its first batch of Starlink satellites in 2021 on Monday (Jan. 18) to expand the company's growing megaconstellation and you can watch the action live online.
The Hawthorne, California-based company will loft 60 Starlink internet satellites on its workhorse Falcon 9 rocket from NASA's historic Pad 39A here at Kennedy Space Center in Florida at 8:45 a.m. EDT (1422 GMT).
You can watch the launch live here and on the Space.com homepage, courtesy of SpaceX, beginning about 15 minutes before liftoff. You can also watch the launch directly via SpaceX.
Related: SpaceX's Starlink satellite megaconstellation launches in photos
SpaceX already has one launch under its belt this year and is looking to ramp up the pace. 2020 was a banner year for the private spaceflight company, which included two different astronaut missions to the International Space Station the first for a commercial company.
It was also the company's busiest launch year to date, with a record 26 flights, smashing the previous record of 18 set in 2018. This year SpaceX has even bigger ambitions, as the company plans to launch 40 rockets between its California and Florida launch sites.
Following liftoff on Monday, the Falcon 9's first stage is expected to land on SpaceX's drone ship, "Just Read the Instructions" in the Atlantic Ocean. (SpaceXs main drone ship, "Of Course I Still Love You," is undergoing maintenance before it returns to service following a busy year.) If successful, the landing will mark the 72nd recovery of a first stage booster for the California-based rocket manufacturer.
The rocket featured in this launch will be another record-setting booster. Known as B1051, this flight proven booster will embark on its eighth flight the first of SpaceX's fleet to do so. It will also mark one of SpaceX's shortest turnaround times between flights as this particular last flew just over a month ago.
To date, B1051 has carried an assortment of payloads, including an uncrewed Crew Dragon spacecraft to the International Space Station as part of a 2019 flight test, followed by a trio of Earth-observing satellites for Canada as well as four different Starlink missions. Most recently, it carried a 15,432-lb. (7,000 kilograms) satellite into orbit for Sirius XM, that will beam down content to Sirius subscribers across the U.S., Canada and the Caribbean.
Related: See the evolution of SpaceX's rockets in pictures
SpaceX created its Starlink internet program to connect users around the globe and provide reliable and affordable internet service, mainly to remote and rural areas. By using a small terminal (no larger than a laptop), users on the ground will be able to connect to the ever-growing network. SpaceX founder and CEO Elon Musk has said that the company needs to launch between 500 and 800 satellites in order to begin rolling out service.
To date, SpaceX has launched more than 1,000 of the internet-beaming satellites into orbit, in an effort to fill out its planned initial constellation of 1,440 spacecraft. SpaceX has already begun beta-testing its space-based internet service, and the initial testing phase has shown that the service is reliable.
The phase is going so well that SpaceX has even started to offer users in the U.K. to help in the beta-testing. The company received a license to start operating in the U.K. last year, thanks to local telecoms regulator Ofcom.
Related: SpaceX launches 60 Starlink satellites in dazzling nighttime liftoff
Monday's launch marks the 102nd flight overall for SpaceXs workhorse two-stage Falcon 9 rocket, as well as the 51st reflight of a Falcon 9 rocket since the company began recovering boosters in 2015.
Over the past five years, the company has honed its recovery efforts, while continuing to prove Falcon 9s reliability. Flying previously flown boosters has now become commonplace for SpaceX, and has allowed the company to launch its rockets at a record pace.
To date, SpaceX has successfully landed its first-stage boosters 71 times. Now that the company has two fully operational drone-ship landing platforms "Of Course I Still Love You" and "Just Read the Instructions" in Florida, its able to launch (and land) more rockets. The newer drone ship on the block, "Just Read the Instructions," is already at the recovery zone waiting for its turn to catch B1051 when it returns to Earth on Monday.
Related: Why SpaceX's Starlink satellites caught astronomers off guard
SpaceX is expected to continue its tradition of recovering the Falcon 9's payload fairing, or nose cone, on this flight. The company has two net-equipped boats called GO Ms. Tree and GO Ms. Chief that it uses to snag the fairings as they fall back to Earth in two pieces.
Each piece of the clamshell-like hardware, which cost approximately $6 million combined, is outfitted with software that navigates it to the recovery zone, and a parachute system that lets them gently land in the ocean or the outstretched net of GO Ms. Tree and GO Ms. Chief.
The boats are also able to scoop the fairings up out of the water as making a midair catch is tricky and dependent upon several factors, like weather and winds. Typically the team decides whether it will catch or scoop the day of launch. And those recovery efforts take place roughly 45 minutes after liftoff.
Currently, weather is 70% go for the launch opportunity on Monday, with the only weather concerns being the potential for cumulus clouds over the launch site. There is a backup launch time on Tuesday if need be. The launch weather that day looks even better, with a 90% chance of favorable launch conditions.
If everything goes as planned, this could mark the first of two SpaceX launches from Florida this week. The Hawthorne, California based company is planning to launch a rideshare mission on Thursday (Jan. 21). And could cap off the month with another Starlink mission.
Follow Amy Thompson on Twitter @astrogingersnap. Follow us on Twitter @Spacedotcom or Facebook.
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SpaceX will launch its 1st Starlink satellites of 2021 on Wednesday. Here's how to watch. - Space.com
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