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Somatic Variant Calling Is Added to OmniTier’s CompStor Novos Genomics Analysis Appliance – Business Wire
Posted: January 21, 2021 at 3:23 pm
SAN JOSE, Calif.--(BUSINESS WIRE)--OmniTier today announced that its genomic secondary analysis appliance, CompStor Novos, has added somatic variant calling from matched, whole genome sequencing (WGS) tumor-normal sample pairs.
About Somatic Variant Calling
The biggest challenge of somatic variant calling is to disambiguate low-frequency variants from artifacts. To solve that challenge OmniTier implemented sensitive statistical modeling to develop a new somatic variant caller that will provide superior accuracy from low to high allele frequencies. CompStor Novos can detect somatic mutations across the whole human genome with coverages up to 300x, reporting SNVs, indels and structural variants from NGS sequenced reads.
About CompStor Novos
CompStor Novos is a high throughput, low cost, easy to use, secondary analysis appliance, supporting Illumina, PacBio and BGI sequencers. Delivering end-to-end, WGS and WES secondary analysis pipelines, CompStor Novos includes both alignment and de novo assembly for genome identification. A GATK Mutect2 variant caller from the Broad Institute, and OmniTiers proprietary, higher accuracy variant caller are also included, providing a choice of caller outputs.
CompStor Novos is designed to be used as an on-premise appliance, or located in the Cloud or at the Edge to deliver secondary analysis services. By locating the CompStor Novos appliance on the same network as their sequencer, institutions can benefit from dramatic annual storage costs savings compared to cloud analysis services, whilst speeding up secondary analysis and throughput. For analyzing very large numbers of genomes quickly, CompStor Novos automatically allocates processing across two or more CompStor Novos appliances.
Availability
Somatic variant calling is included at no additional charge to new CompStor Novos customers, and for those customers on support and maintenance.
For a limited time OmniTier is offering a free trial to demonstrate CompStor Novos variant output results. Please contact us for more information.
About OmniTier
OmniTier develops AI and multiomics appliances and software for bioinformaticians and clinical researchers, that deliver affordable analysis solutions. Its integrated appliance solutions accelerate data-intensive genomic workflows and analysis, utilizing machine learning and AI. Founded in February 2015, the company has R&D operations in Milpitas, CA and Rochester, MN.
CompStor Novos is for research purposes only. CompStor Novos is a registered trademark of OmniTier, Inc.
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Tumor Genomic Subtype Might Influence Level of ctDNA Shedding in NSCLC – Cancer Therapy Advisor
Posted: at 3:23 pm
The genomic subtype of a tumor may contribute to the level of circulating tumor DNA (ctDNA) shedding in patients with advanced nonsmall cell lung cancer (NSCLC), according to the results of a retrospective study reported in the Journal of Thoracic Oncology that could have implications for the clinical utility of ctDNA testing in early detection and disease monitoring.
The analysis included 144 patients with advanced NSCLC who had ctDNA testing performed at The University of Texas MD Anderson Cancer Center in Houston between November 2015 and July 2017. All patients had a computed tomography scan and brain magnetic resonance imaging to measure tumor burden within 30 days of ctDNA sampling. Genomic subtypes seen in the study population included TP53 mutation (53.5%), KRAS mutation (22.9%), EGFR mutation (39.6%), and ALK fusion (2.8%).
The analysis showed that ctDNA variant allele frequency (VAF) was significantly associated with tumor burden, as determined by CT volume (rho=0.34; P 0.0001) and metabolic tumor volume (rho=0.36; P =0.003).
While positive, the modest correlation observed between VAF and tumor burden in our cohort suggests that other factors also significantly impact ctDNA shedding, the study authors wrote.
All genomic subtypes assessed were found to have an association between ctDNA VAF and tumor burden. This association varied by genomic subtype. For example, tumors with KRAS mutations had the strongest association (rho=0.56; P 0.001) while tumors with EGFR mutations had the weakest (rho=0.24; P =0.077).
A multivariate analysis revealed that TP53 mutations (HR, 1.45; 95% CI, 1.16-1.80; P =0.001) and EGFR mutations (HR, 1.36; 95% CI, 1.08-1.71; P =0.009) were both independent predictors of elevated ctDNA shedding.
Among tumors with EGFR mutations, those that had EGFR copy number gain had a significantly higher ctDNA VAF compared with tumors without EGFR copy number gain (P 0.00001).
Visceral metastasis (hepatic, adrenal, renal, or splenic) was also an independent predictor of elevated ctDNA shedding (HR, 1.48; 95% CI, 1.16-1.91; P =0.002), as was tumor burden (HR, 1.00; 95% CI, 1.00-1.00; P <0.001), according to a multivariate analysis.
Our findings strongly suggest that ctDNA shedding is not only impacted by tumor burden but also by anatomic location and genomic subtype, the study authors concluded.
Disclosures: Some of the study authors disclosed financial relationships with the pharmaceutical industry and/or themedicaldeviceindustry. For a full list of disclosures, please refer to the original study.
Reference
Lam VK, Zhang J, Wu CC, et al. Genotype-specific differences in circulating tumor DNA levels in advanced NSCLC. J Thorac Oncol. Published online December 31, 2020. doi:10.1016/j.jtho.2020.12.011
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How Will Global CRISPR Genome Editing Market React from 2021 Onwards? The Courier – The Courier
Posted: at 3:23 pm
The report by Zion Market Research titled How Will Global CRISPR Genome Editing Market React from 2021 Onwards?Research Reportpresents a profound comprehension regarding the functioning and expansion of theCRISPR Genome Editing Marketon a regional and global level. This analysis report is the collation of all the wide-ranging information relating to the market statistics during the recent years as well as forecasts for coming years. To begin with, the report comprises the major players actively participating and competing within the CRISPR Genome Editing Market; it entails several companies, manufacturers, suppliers, organizations, and so on. Thus, the report will assist in understanding the initiatives and approaches implemented by these players to create and reinforce their market presence. The thorough analysis presents a wide-ranging comprehension of the global market in a knowledgeable way. The client can merely point out the steps of the firm by having details regarding their global revenue, market share, price, production & capacity, and recent developments during the forecast period.
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The research report includes the outline of the global CRISPR Genome Editing Market such as definition, classifications, and applications. Apart from this, it entails the comprehensive assessment of a number of factors like constraints, opportunities, drivers, challenges, and risk. Further, the global CRISPR Genome Editing Market is bifurcated on the basis of diverse parameters into respective segments as well as sub-segments. The report also encompasses the existing, previous, and likely growth trends within the market for each segment and sub-segment[Product, Applications, End-Users, and Major Regions]. Additionally, the market is also segregated based on regions[North America, Europe, Asia-Pacific, Latin America, The Middle East & Africa].along with detailed evaluation of their growth, key developments & strategies, opportunities, and the key patterns influencing the market expansion in those regions. The report will further also entail a particular part putting forth the changes and of the ongoing COVID-19pandemic. It comprises-depth market analysis rooted in the predictions of post-COVID-19 market circumstances together with data on the existing impacts on the CRISPR Genome Editing Marketof the pandemic.
Global CRISPR Genome Editing Market: Regional Segment Analysis
The research report also highlights the wide array of tactical steps, such as the latest business deals, joint ventures, partnerships, M&As, technological developments, and the launch of new products taking place in the market. In addition, it scrutinizes several patterns of the global CRISPR Genome Editing Market, entailing the rules, criteria, and policy deviations implemented by the private companies and government on the market over the last few years. As a final point, the analysis includes forecasts and historic data making it a beneficial asset for experts, industry executives, presentation, sales & product managers, consultants, and every other person or organization looking for essential market data and statistics.
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Zion Market Research is an obligated company. We create futuristic, cutting-edge, informative reports ranging from industry reports, the company reports to country reports. We provide our clients not only with market statistics unveiled by avowed private publishers and public organizations but also with vogue and newest industry reports along with pre-eminent and niche company profiles. Our database of market research reports comprises a wide variety of reports from cardinal industries. Our database is been updated constantly in order to fulfill our clients with prompt and direct online access to our database. Keeping in mind the clients needs, we have included expert insights on global industries, products, and market trends in this database. Last but not the least, we make it our duty to ensure the success of clients connected to usafter allif you do well, a little of the light shines on us.
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COVID-19: Genomic sequencing finds 17 of NZ’s recent cases are the mutated UK, South African variants – Newshub
Posted: at 3:23 pm
A number of other previously identified strains have also been detected by whole genome sequencing, the ministry said.
The lineages are all consistent with overseas exposure, the ministry confirmed, reiterating that the 17 infections were detected due to routine testing in managed isolation facilities.
New Zealand has now recorded 29 cases of B.1.1.7, the mutated strain currently ravaging the United Kingdom, and seven infections of B.1.3.5.1, the South Africa variant.
"We expect we will continue to see both the UK variant and South Africa variant in positive cases in our managed isolation facilities here in New Zealand, as these forms of the virus become increasingly common around the world," the Ministry of Health said in Thursday's statement.
"All positive COVID-19 tests in New Zealand are sent to ESR to attempt whole genome sequencing as part of ongoing surveillance.
"This surveillance allows us to identify and better understand these variants in order to inform and refine our overall elimination strategy, in particular optimising our current stringent border processes including testing and regularly reviewing infection prevention procedures."
The healthcare department noted that further steps have been recently taken to strengthen New Zealand's border processes, including an additional test for returnees on arrival or day one of their stay in managed isolation. Pre-departure testing is now also required for all passengers planning to enter New Zealand, with the exception of travellers returning from Australia, Antarctica and the majority of the Pacific Islands.
On Wednesday, the Ministry of Health confirmed that six new imported cases had been detected in managed isolation facilities over the previous two days, including one who tested positive more than three weeks after arriving in the country. The person has been at the Jet Park Hotel, Auckland's quarantine facility, since the new year.
The ministry's next update is scheduled for 1pm on Friday, January 22.
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COVID-19: Genomic sequencing finds 17 of NZ's recent cases are the mutated UK, South African variants - Newshub
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Ron Paul: The Unwelcome Return Of The Real Purveyors Of Violence – OpEd – Eurasia Review
Posted: January 19, 2021 at 9:23 am
With the mainstream media still obsessing about the January 6th violent coup attempt at the US Capitol Building, the incoming Biden Administration looks to be chock full of actual purveyors of violent coups. Dont look to the mainstream media to report on this, however. Some of the same politicians and bureaucrats denouncing the ridiculous farce at the Capitol as if it were the equivalent of 9/11 have been involved for decades in planning and executing real coups overseas. In their real coups, many thousands of civilians have died.
Take returning Assistant Secretary of State Victoria Nuland, for example. More than anyone else she is the face of the US-led violent coup against a democratically-elected government in Ukraine in 2014. Nuland not only passed out snacks to the coup leaders, she was caught on a phone call actually plotting the coup right down to who would take power once the smoke cleared.
Unlike the fake Capitol coup, this was a real overthrow. Unlike the buffalo horn-wearing joke who desecrated the sacred Senate chamber, the Ukraine coup had real armed insurrectionists with a real plan to overthrow the government. Eventually, with the help of incoming Assistant Secretary of State Nuland, they succeeded after thousands of civilians were killed.
As we were unfortunately reminded during the last four years of the Trump Administration, the personnel is the policy. So while President Trump railed against the stupid wars and promised to bring the troops home, he hired people like John Bolton and Mike Pompeo to get the job done. They spent their time clarifying Trumps call for ending wars to mean he wanted to actually continue the wars. It was a colossal failure.
So its hard to be optimistic about a Biden Administration with so many hyper-interventionist Obama retreads.
While the US Agency for International Development (USAID) likes to sell itself as the compassionate arm of the US foreign policy, in fact USAID is one of the main US regime change agencies. Biden has announced that a top humanitarian interventionist Samantha Power would head that Agency in his Administration.
Power, who served on President Obamas National Security Council staff and as US Ambassador to the UN, argued passionately and successfully that a US attack on the Gaddafi government in Libya would result in a liberation of the people and the outbreak of democracy in the country. In reality, her justification was all based on lies and the US assault has left nothing but murder and mayhem. Gaddafis relatively peaceful, if authoritarian, government has been replaced by radical terrorists and even slave markets.
At the end of the day, the Bush Republicans like Rep. Liz Cheney will join hands with the Biden Democrats to reinstate American leadership. This of course means more US overt and covert wars overseas. The unholy alliance between Big Tech and the US government will happily assist the US State Department under Secretary of State Tony Blinken and Assistant Secretary of State Nuland with the technology to foment more regime change operations wherever the Biden Administration sees fit. Finish destroying Syria and the secular Assad? Sure! Go back into Iraq? Why not? Afghanistan? Thats the good war! And Russia and China must be punished as well.
These are grave moments for we non-interventionists. But also we have a unique opportunity, informed by history, to denounce the warmongers and push for a peaceful and non-interventionist foreign policy.
This article was published by RonPaul Institute
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Ron Paul: The Unwelcome Return Of The Real Purveyors Of Violence - OpEd - Eurasia Review
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Premature pension in New Haven is $117000; and a new hidden tax is coming – Journal Inquirer
Posted: at 9:23 am
Last week this column examined the government pension racket in Connecticut through the example of the "retirement" of New Haven Police Chief Tony Reyes, who is only 49 and is giving up his city salary of $170,000 to become police chief at Quinnipiac University in adjacent Hamden. Since New Haven City Hall needed a week before it could provide an estimate of the annual pension Reyes immediately will begin receiving, last week's column surmised it might amount to $80,000.
That was low. The city's budget office now estimates Reyes' annual pension at $117,000.
While Quinnipiac is a nonprofit institution exempt from federal, state, and municipal taxes and thereby is subsidized by all levels of government, the university won't disclose what it will pay Reyes. But his salary there likely will equal or exceed his salary with the city. That would mean annual income for him of at least $287,000 for his remaining 15 or so years of a typical working life. That's getting close to the $319,000 salary now being paid by the University of Connecticut to its former president, Susan Herbst, who is now teaching just one or two political science courses at UConn's Stamford branch -- essentially another premature pension -- after enjoying a year of paid vacation costing UConn $711,000.
Social Security, the pension system covering most people who do not work for the government, penalizes those who begin claiming benefits prior to the standard retirement age but continue to work for wages. The benefits of such people are reduced. But Connecticut's government pension systemrewardspeople for working for wages while also collecting benefits, thereby signifying that government employees are better and more deserving than the people who pay for them.
This practice is somehow called public service, and while it is all taxpayer money, it draws no objection from the governor, state legislators, and mayors like New Haven's Justin Elicker, who are always pleading poverty.
* * *
ANOTHER HIDDEN TAX: Now Democratic state legislators are planning to impose another hidden tax like the "gross receipts tax" levied on wholesale gasoline prices, which drivers pay without seeing it posted at the gas pump or anywhere else.
The Democrats' new idea is to tax medical insurance companies as the federal government did until recently in the name of raising money for insurance for the poor. This tax would drive up insurance costs for everybody while giving the false impression that the big, bad insurance companies had raised prices again. The Democrats' idea presumes that medical insurance isnotalready expensive enough for nearly everyone.
Government already imposes hidden taxes on medical insurance by requiring policies to provide discretionary coverage many people don't want.
While government should facilitate decent medical insurance for all, people always should be given a clear view of government's cost. Other than deceiving voters, there is no justification for hiding the cost of insurance for the poor in the insurance bills of others.
The additional tax burden would be clearer if the revenue was drawn from general state taxes, like the income and sales taxes. Then insurance for the poor would compete in the open with all other demands on government.
Until people can see clearly how they are taxed, they are not likely to insist on efficiency and better priorities in government, like ending the pension racket.
* * *
MURPHY LOOKS AWAY: Last week Connecticut U.S. Sen. Chris Murphy deplored the decline of press freedom in Ethiopia. Meanwhile the giant social media companies in the United States began censoring President Trump, former U.S. Rep. Ron Paul, and others because of their political views.
That did not bother the senator.
Additionally, in recent years one national media company has acquired half the daily and weekly newspapers in Connecticut and another three companies have acquired most major radio and television stations in both the state and the country -- again without objection from the senator.
Is the senator unaware of the worsening concentration of media ownership at home and the resulting reduction of voices? Or does he realize that while nothing about Ethiopia can ever hurt him, challenging the concentration of media ownership here might?
Chris Powell is a columnist for the Journal Inquirer.
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Premature pension in New Haven is $117000; and a new hidden tax is coming - Journal Inquirer
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As Fed Chair, Janet Yellen Discounted Economic Desperation. The Pandemic Will Likely Force a Different Approach. – The Intercept
Posted: at 9:23 am
In December, the economy lost 140,000 jobs, with a total of 9.8 million job losses since the coronavirus pandemic began. Rent debt could be as high as $70 billion. Fifty-four million Americans face food insecurity, an increase of 17 million from pre-pandemic levels. Mass transit cuts are happening across the country, further isolating low-income individuals, making them more dependent on expensive Uber and Lyft rides, and triggering job losses.
Yellens tenure at the Fed, which included rate hikes that almost certainly caused higher unemployment rates from 2015 through 2017, demonstrates that Yellen has, in the past, overestimated the strength of the economy for working people.
Her recent statements, however, suggest that the pandemic, along with the run of wage growth and unemployment decline after 2017 many economists thought wasnt possible, has altered her thinking, and she now believes in aggressive action by the Fed and Treasury to continue to lift up the economy. In October, Yellen said, While the pandemic is still seriously affecting the economy, we need to continue extraordinary fiscal support. We need support for the economy from both monetary and fiscal policy.
Which direction she chooses austerity or stimulus, deficits or employment will have enormous import for this deeply divided country.
The late journalist William Greider called his masterpiece 1987 book on the Fed Secrets of the Temple because the Fed gives itself an aura of impenetrability, too dense or complex for ordinary people to understand. Greider revealed that this is a deliberate political choice by the Fed to insulate its decision-making from democratic oversight.
The key problem is that the Fed has two mandates that are at odds: control inflation and expand employment. Inflation is often used by monetary policymakers as a proxy for wage growth for working people. So if the Fed seeks to control inflation, wage growth slows and unemployment goes up; if the Fed seeks to expand employment, the way the Fed measures inflation means that inflation will go up. Former Fed Chair Paul Volcker kept a card that detailed construction worker wages in his pocket, seeing his mission to fight inflation as inseparable from stagnating the wage growth of the working class.
Inflation has been a reflection of class struggles, said Samir Sonti, a professor at the CUNY School of Labor and Urban Studies. In the late 70s the Volcker Fed responded to wage inflation with monetary austerity without precedent, and the result was a recession that broke the back of the industrial labor movement.
Since the early 80s we havent seen any real consumer price inflation and that is an expression of the weakening power of the organized working class, Sonti said. What weve seen is asset price inflation which is enabled by interest rates that can be kept low because theres no significant working class threat.
Yellen was appointed to the Fed in 2013, beating out Larry Summers for Obamas nomination. Progressives despised Summers and worked against a potential Summers nomination, not least because he had worked with former Obama chief of staff Rahm Emanuel to limit the size of the $900 billion stimulus in 2009 famously not even showing a proposal for a $1.8 trillion stimulus crafted by economic advisers Christina Romer and Jared Bernstein to the president for review. While by 2013 there had been significant economic recovery since the Great Recession, millions of Americans were still struggling, with 13 percent of the working age population unemployed or unemployed.
On December 16, 2015, Yellen announced that the Fed had raised interest rates for the first time in a decade. I feel confident about the fundamentals driving the U.S. economy, the health of U.S. households, and domestic spending, Yellen said. There are pressures on some sectors of the economy, particularly manufacturing, and the energy sector but the underlying health of the U.S. economy I consider to be quite sound.
At that point, there were still nearly 16 million people either unemployed or significantly underemployed in the U.S., or 9.9 percent of the population (otherwise known as the U-6 unemployment rate). The inflation rate in the year prior was just 0.12 percent, the second lowest year on record since 1960. The Fed raised interest rates again in December 2016, when the inflation rate was 1.26 percent, well below the Feds 2 percent target rate.
Mainstream economists have praised Yellens record. Under Janet Yellen the United States achieved some of the best outcomes in terms of both low and falling unemployment rates and stable inflation we have enjoyed in the postwar period, you can quibble with any given decision but the overall outcome was very good, said former Obama economic advisor Jason Furman, who was referred to The Intercept by the Biden transition.
But others have said that Yellen raised rates too soon, artificially slowing down the economy while millions were out of work. The soft 2016 economy contributed to the election of President Donald Trump. She presided over a premature rate increase, said Rohan Grey, a professor at Willamette University College of Law. She was the chair and this was a decision made by her board. Its pretty clear that was premature. What it shows is that even someone who has framed themselves as a dove and pro-labor is that when push comes to shove she wont stand out. She was in power and they prematurely tightened the economy and thats a big problem.
Yellen oversaw four more rate hikes during her time as Fed chair, one at the end of the Obama administration and three during her overlap with the Trump administration. The economy continued to grow, but the U-6 unemployment rate never dropped below 8 percent. The activistcampaign Fed Upcontinuously urged the Fed to hold off on increasing interest rates, with concerns that it would prevent more Americans from getting jobs. In spite of those criticisms, the group did urge Trump to reappoint her as Fed chair.
Grey also raised concerns about Yellens closeness to deficit fearmongering groups like Fix the Debt. Yellen is a member of the advisory boards for both Fix the Debt and the Committee for a Responsible Federal Budget, which advocate for cuts to Social Security and Medicare.
She said on the record that the national debt and the size of deficits has a sustainability concern in the long run, said Grey. And has in the past conceded that benefit cuts could help to address it. Its a classic right-wing trope. Shes liked more by team blue but her language is not too different from Paul Ryan or Ron Paul.
Sonti, the CUNY professor, for his part said that the economic impact of the pandemic may have altered Yellens thinking: The crisis is of such magnitude that even the technocratic elite are likely aware of the need to change course.
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As Fed Chair, Janet Yellen Discounted Economic Desperation. The Pandemic Will Likely Force a Different Approach. - The Intercept
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Opinion: Trump’s social media ban raises a question what are the rules and who enforces them? – The San Diego Union-Tribune
Posted: at 9:23 am
The United States and the world in general are in an unprecedented place when it comes to basic issues of free speech. The emergence of Facebook and Twitter as mass purveyors of speech and the related emergence of a cancel culture in which people and groups try to shut down those with views they find offensive has created a complicated, unsettling array of issues. Its now close to inevitable that some governments worldwide will respond to the question of whether the private sector especially giant tech firms based in California gets to decide what speech is acceptable and what is not.
Three recent cases raise basic free speech issues.
Facebook and Twitter removed President Donald Trumps accounts from their global platforms in recent weeks after concluding that he was attempting to foment violence by his supporters over his false claim that he was cheated out of re-election. He brought that on himself. Yet the social networks did nothing in response to similar incendiary communications by politicians in Myanmar, India, Sri Lanka, the Philippines and Brazil that led to lynchings, pogroms, extrajudicial killings or ethnic cleansing, as the Los Angeles Times reported.
The leaders of Germany, Mexico and Australia raised another concern as well: They said a decision to shut off an elected officials prime means of communicating with a nation should be made by a government, not a CEO. This is a fair point but it is hard to see the irresponsible Trump as a victim.
Drawing a line at incitement of violence is easy, and essential. Deciding what else goes too far will be more difficult, but social media giants have had problems for years with users complaining of abuse, harassment and threats. Theyve known this day was coming. In plain language, Facebook and Twitter need to explain what is and isnt acceptable for posting. Increasingly, they are being considered for greater government regulation la utility companies. That almost seems inevitable. Ultimately, Donald Trumps most lasting legacy may be his role in the overdue reckoning of social media sites.
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Opinion: Trump's social media ban raises a question what are the rules and who enforces them? - The San Diego Union-Tribune
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Ron Williams named National Western Stock Show’s Citizen of the West for 2022 – The Know
Posted: at 9:23 am
Denver business leader and former National Western Stock Show chairman Ron Williams was named Citizen of the West, although Williams will not receive the award this year due to the Stocks Shows postponement. (Provided by National Western Stock Show)
The National Western Stock Shows 2021 postponement has been disappointing for countless participants and attendees, even as its allowed the complexs $1 billionconstruction project to push forward.
But its highest honor, the Citizen of the West, could not skip a year.
I wasnt expecting it, said Ron Williams, the 74-year-old business leader, philanthropist and former National Western Stock Show chairman who received the award this week. But I knew Id be terribly appreciative if I did. There are a lot of great candidates for it here, but Im honored I ended up being the one for this coming year.
The annual Citizen of the West award recognizes those who embody Western pioneers spirit and determination and perpetuate their agricultural heritage and ideals, stock show officials said. A committee of community leaders, including past winners such as Bruce and Marcy Benson (2020s recipients), select each new winner.
Despite this weeks announcement, Williams will not formally receive the award until Jan. 22, 2022, during the Stock Shows planned return.Proceeds from the dinner will support 100 scholarships that the National Western Scholarship Trust awards annually to students in Colorado and Wyoming who major in agricultural science, rural medicine or veterinary medicine, stock show officials said.
I felt it was important that we announce this during the time when the show had been postponed so we can celebrate Ron Williams the entire year, said Paul Andrews, president and CEO of the National Western Stock Show. Well be celebrating the opening of the new Cilland Ron Williams Stock Yards at the 2022 show, as well as the new Hutchinson Western Stockyards, so that will make it a commemorative ticket.
For Williams and his wife, Cill, it will be the latest and greatest recognition in a career full of them. Williams was born in a small town in Nebraska, one of only 10 kids in his rural school and 300 people in his entire town, according to a 2016 CoBiz profile.
When I was 10 years old I was driving a tractor for my uncle, so Ive always been involved in agriculture at some level, said Williams, who came to Denver in 1967after graduating with his masters degree from the University of Nebraska in Lincoln.
Here, Williams worked as an accountant for Arthur Anderson and, in 1977, joined Samuel Gary Oil Producer Inc. (later Gary-Williams Energy), where he would become an owner, president and CEO. That companys community investment division, The Piton Foundation, supported nonprofits including the Colorado Childrens Campaign, Denver Preschool Program, Urban Land Conservancy and others.
This is where Mr. Williams first became involved in and found a passion for philanthropy, stock show officials said.
Nineteen-sixty-seven may seem like a long time ago, but its not that long to me, Williams said. Although, when I came to Denver the tallest building in town then was the 31-storySecurity Life Building (now 1600 Glenarm Place). If you went out for lunch at noon, youd walk a block and see five people that you knew. The growth has been dramatic but, for the most part, I think its been managed well.
Over his years as a metro-area business leader including a 2016 induction into the Colorado Business Hall of Fame Williams flexed his philanthropic muscle by helping lead the capital campaign to raise private funds for a new state-of-the-art Childrens Hospital at the Fitzsimons Campus in Denver, gathering $250 million.
He also served on the board of directors for the Denver Public Schools Foundation for a decade, where he raised $10 million for the organization, and on the board of the University of Colorado Hospital. Hes a longtime member of the powerful Colorado Forum of business leaders. But, even as he attended the National Western Stock Show annually, it wasnt until 2004that he joined the stock shows board.
Pat Grant (former National Western chairman) asked if I would consider it then, Williams said, and it took me about two seconds to say, Absolutely.
A natural fit for the organization, Williams has brought attention and support to National Western projects ever since then. He acted as chairman for a time and, starting next year, will be able to see his and his wifes name on one of its busiest stockyards. Williams still owns a little cattle ranch in Kansas, Andrew said.
Hes just a tremendous selection for this award, he said. Hes given so much in terms of philanthropy his entire career. Hes found this balance between being a very tough businessman and being fair and caring about people. Nobody I know cares about people more than Ron. I dont think he has an enemy in Colorado, and our entire staff loves him to death.
Williams said hes still focused on bringing the stock show back, and keeping the organization strong in the meantime.
A lot of people in the agriculture industry, along with ranchers, hog raisers they come to us because this is almost like an educational vocation for them, Williams said. At the stock show, they get to meet their peers, learn and do business with each other. Theres a lot that goes on down in those yards each January.
Without a stock show this year, however, Williams will also continue his philanthropic work. Its contributed as much to his own happiness as his business successes, he said.
Its funny how, if you step out of your comfort zone and get involved in things like that, it changes your perspective on whats important, he said. I like to think we can learn from everyone we meet by taking little pieces of what works and integrating that into ourselves.
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Toby Gardenhire to Manage the Saint Paul Saints – KSOO News
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The first manager of the new Minnesota Twins triple-A ball club Saint Paul Saints will be announced on Tuesday and a familiar last name will be heard. Toby Gardenhire, the son of former Twins manager Ron Gardenhire will be leading the team.
The 38-year old Gardenhire himself played AAA ball for two seasons and has played in the minors since 2005. He managed in the farm system out of Cedar Rapids in 2018 and Fort Myers in 2019. Originally drafted by the Twins in the 41st round of the 2005 MLB draft. He was invited to Spring Training in 2010 by Minnesota.
Get those guys to the big leagues, thats the plan Im excited, Gardenhire, 38, said Monday while playing in Twins first base coach Tommy Watkins fundraiser golf tournament in Florida. -St. Paul Pioneer Press
Does he have big shoes to fill and will he manage in the shadows of his big-league-manager-father? Maybe after watching dad get tossed out of games 85 times he will have a calmer demeanor but with the same intense coaching approach.
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Toby Gardenhire to Manage the Saint Paul Saints - KSOO News
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