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Itchy scalp: 5 common causes and best treatments – Netdoctor
Posted: February 21, 2021 at 12:23 am
Can't stop itching your head? An itchy scalp is an incredibly common (and often very frustrating) condition, but it's not usually the sign of anything more serious. However, some itchy scalp signs can indicate that something needs treating and madly itching the area can make things worse.
Dr Roger Henderson looks at the most common causes and best treatment options for an itchy scalp and what you can do to prevent the dreaded itch from returning:
An itchy scalp also called scalp pruritis is a common problem. Although rarely due to a serious condition, it can cause significant discomfort thanks to frequent scratching and there may also be signs such as flaking skin or sores on the scalp.
Unsurprisingly, the main cause of an itchy scalp is the itching, but the scalp can also feel painful or tingling. Scratching may cause a temporary easing of the itch but it then recurs. Other associated problems may include hair loss, dry skin, infected sores, scalp swelling and scales on the scalp.
There are five typical causes of an itchy scalp, listed below. Other possible but less common itchy scalp causes include diabetes, allergies, anxiety, contact dermatitis (due to the scalp reacting to something it has been in contact with), excessive heat due to hair styling and alopecia. The best itchy scalp treatment depends on the cause:
Dandruff, also known as pityriasis capitis, is the most common cause of a dry, flaky and often itchy scalp. Most people are familiar with the appearance of tiny white flakes of dead skin on the shoulders of people that suffer from it, and it can affect up to half of all adults at some time.
Dandruff is not caused by poor hygiene, although it may be more obvious if you do not wash your hair regularly. Dandruff is due to dead skin cells being shed more rapidly than usual, and left untreated it can cause embarrassment and self-esteem problems. Using certain hair products excessively can sometimes lead to dandruff occurring and stress and cold weather may also make dandruff worse.
Dandruff is best treated with anti-dandruff shampoos that can be bought from pharmacies or supermarkets. Look for a shampoo containing one of these ingredients:
Use the shampoo for a month to see if your dandruff improves as you might need to try more than one type to find one that works for you. If you still have symptoms after using anti-dandruff shampoo for a month or if your scalp remains very itchy or reddened, then ask your GP for advice.
Seborrhoeic dermatitis affects around 3- 4 per cent of the population, and can start at any time after puberty. It is slightly more common in men and also runs in families. Babies can also get a short lived type of seborrhoeic dermatitis in the scalp known as cradle cap which usually clears after a few months.
Seborrhoeic dermatitis is thought to be triggered by an overgrowth of the Malassezia yeast that lives on the skin, or possibly by an overreaction by the skins immune system to this yeast. Seborrhoeic dermatitis is not usually linked to any underlying illness, but may be triggered by tiredness and stress. It is more common in cold weather, and it is not related to diet.
The symptoms of seborrhoeic dermatitis seem to vary from person to person. Affected areas can be itchy, sore and sensitive and flaking skin can be bothersome and embarrassing, while some people are not troubled by it.
Seborrhoeic dermatitis is best treated with a medicated shampoo such as an anti-dandruff or an anti-fungal shampoo such as ketoconazole. For best results, wash the shampoo into the scalp, then wait 5-10 minutes before rinsing. Thick scales can be removed before shampooing by applying a descaling preparation containing coconut oil and salicylic acid for several hours beforehand. If the irritation is severe your doctor may prescribe a steroid scalp lotion, gel or shampoo for occasional use.
Ringworm is not caused by any kind of worm but is due to a simple fungal infection that causes dry scaly hair patches and a classical ring of redness in the affected area. It can be passed from person to person, usually via hairbrushes and towels and can also affect other parts of the body such as the groin (known as jock itch) and trunk.
Ringworm does not usually respond well to antifungal shampoos as the infection goes deep into the hair follicles where shampoos cannot reach. It is best treated with oral antifungal tablets. To help stop ringworm from spreading, start treatment as soon as possible, wash your towels and bedsheets regularly, and take your pet to the vet if it looks as if they might have ringworm (such as having patches of missing fur).
Head lice are small grey-brown insects up to 3mm long that live on the scalp and can be difficult to spot in the hair. Head lice eggs (nits) are brown or white (empty shells) and attached to the hair. They are most commonly spread by head-to-head contact and can cause an itchy scalp if it is sensitive to the faeces or saliva of the lice. Although most common in children head lice can affect people at any age.
Head lice can be treated with over-the-counter preparations available from pharmacies but the current best advice is to try wet-combing first. Try the following wet-combing tips:
If you have tried wet combing for 17 days but live head lice are still present, ask a pharmacist for treatment.
Psoriasis is a common skin disease affecting 1 in 50 people, occurring equally in men and women and appearing at any age. Psoriasis is a long-term condition which may come and go throughout your lifetime, and is not infectious. It often affects the scalp and about half of people with the most common form of psoriasis (called plaque psoriasis) have scalp involvement. It causes a dry, scaly itchy rash that typically affects the hairline at the back of the head often giving the false impression that it is severe dandruff.
Scalp psoriasis is usually treated first with a coal-tar based shampoo and there are several such shampoos for treating scalp psoriasis available from your local chemist. These shampoos are designed to treat the scalp rather than washing hair so you can use a normal shampoo and conditioner afterwards to reduce any smell of tar. When using a tar shampoo you should massage the shampoo into the scalp and leave for 5-10 minutes before rinsing out. Tar shampoo alone is not recommended for treatment of severe scalp psoriasis (ie where there is thick scaling and redness) but is usually effective if there is only relatively mild flaking.
If this is not effective your GP may prescribe a strong steroid lotion (avoid using on the face and ears) that is used for a few weeks to bring the psoriasis under control. This can then be gradually phased out, switching to maintenance treatment with a coal tar shampoo.
Occasionally, Vitamin D derivatives - available as ointment, gel or lotion can be used in troublesome scalp psoriasis. These usually applied to the scalp once or twice a day and do not need to be washed out. They also do not smell or stain clothing, and are relatively easy to use.
If you have a condition such as psoriasis it may be extremely difficult to prevent this occurring but as a general point always wash your hair regularly to remove any built-up oils, and always in warm rather than hot water as this can help to prevent scalp irritation and drying. Try to avoid using scalp products containing fragrances, dyes or chemicals, and do not share items such as combs, brushes, hats and towels with other people.
Natural treatments which can be effective for an itchy scalp that does not require medical treatment include:
Last updated: 15-02-2021
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Itchy scalp: 5 common causes and best treatments - Netdoctor
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Arcutis Announces Fourth Quarter and Full Year 2020 Financial Results and Provides Business Update – Yahoo Finance
Posted: at 12:23 am
NDA submission for topical roflumilast cream as a potential treatment for plaque psoriasis anticipated in the second half of 2021
Positive Phase 3 data on topical roflumilast cream in plaque psoriasis reported in February
Advancing topical roflumilast into Phase 3 programs for atopic dermatitis, seborrheic dermatitis, and scalp psoriasis during 2021
Robust pipeline addressing unmet medical needs of over 20 million patients
Strong financial position with over $470 million in cash, cash equivalents and marketable securities, including the proceeds from recent equity offering, providing cash runway into 2023
WESTLAKE VILLAGE, Calif., Feb. 16, 2021 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT), a late-stage biopharmaceutical company focused on developing and commercializing treatments for unmet needs in immune-mediated dermatological diseases and conditions, or immuno-dermatology, today reported financial results for the quarter and year ended December 31, 2020, and provided a business update.
2020 was a year of incredibly strong execution for Arcutis, said Frank Watanabe, Arcutis President and Chief Executive Officer. From our initial public offering in February through implementation of 18 clinical trials with three different product candidates involving more than 3,200 patients, we made tremendous progress advancing our mission of addressing significant unmet needs in medical dermatology. I am unbelievably grateful to the patients and physicians participating in our clinical trials, and to our amazing Arcutis team. This effort culminated in multiple notable milestones, including our recently reported positive pivotal Phase 3 results in plaque psoriasis, positive Phase 2 results in atopic dermatitis, seborrheic dermatitis, and scalp psoriasis, and the landmark publication of plaque psoriasis Phase 2b data in the New England Journal of Medicine.
Mr. Watanabe continued, 2021 will be a transformational year for Arcutis as we continue to rapidly advance our innovative and differentiated late-stage pipeline of potential best-in-class topical dermatology therapies. Based on positive Phase 3 data, we anticipate submitting a New Drug Application to the FDA for topical roflumilast cream as a potential once daily topical treatment for plaque psoriasis this year. We are excited to advance three additional programs into pivotal Phase 3 trials in 2021. Our focus on addressing the gap in dermatology drug development currently includes four product candidates in development for seven indications, with an addressable U.S. market of over 20 million patients, representing a potential revenue opportunity of between $3 billion and $8 billion.
Story continues
Pipeline Updates
ARQ-151 (topical roflumilast cream) - a highly potent and selective phosphodiesterase type 4 (PDE4) inhibitor in a cream formulation, being developed as a potential treatment for plaque psoriasis, including intertriginous psoriasis, and atopic dermatitis.
Reported positive results from the two pivotal Phase 3 clinical trials (DERMIS-1 and DERMIS-2) in patients with plaque psoriasis; New Drug Application (NDA) submission to U.S. FDA anticipated in the second half of 2021.
Pivotal Phase 3 trials in patients with atopic dermatitis (INTEGUMENT-1 and INTEGUMENT-2) initiated in January 2021 with topline data anticipated in the second half of 2022.
Reported positive results from the Phase 2 long-term safety study as a potential once-daily chronic topical treatment for plaque psoriasis.
ARQ-154 (topical roflumilast foam) - a highly potent and selective phosphodiesterase type 4 (PDE4) inhibitor in a foam formulation, designed to overcome the challenges of delivering topical drugs in hair-bearing areas of the body, being developed as a potential treatment for seborrheic dermatitis and scalp psoriasis.
Reported positive topline data from Phase 2b study in patients with scalp and body psoriasis which affects more than 2.5 million of the 6 million psoriasis patients in U.S with active disease.
Announced advancement of seborrheic dermatitis into Phase 3 development, anticipating initiation of a single pivotal Phase 3 study (STRATUM) in the second or third quarter of 2021, with topline data anticipated in the second or third quarter of 2022.
Pending discussions with regulators, the Company expects to initiate its Phase 3 program in scalp psoriasis in the second half of 2021, with topline data anticipated in the second half of 2022.
ARQ-252 - a potent and highly selective topical small molecule inhibitor of Janus kinase type 1 (JAK1), being developed as a potential treatment for chronic hand eczema and other inflammatory dermatoses.
Completed enrollment of the ongoing Phase 1/2b study in chronic hand eczema, with topline data anticipated by mid-2021.
The Company anticipates initiating a Phase 2a study in vitiligo in the first quarter of 2021.
ARQ-255 - an alternative topical formulation of ARQ-252 designed to reach deeper into the skin in order to potentially treat alopecia areata.
Recent Corporate Highlights
Terrie Curran appointed to Arcutis Board of Directors
Arcutis common stock (ARQT) added to the Nasdaq Biotechnology Index
Matthew Moore joined the Company as Chief Business Officer
Completed underwritten public offering of common stock in February 2021 with gross proceeds of $221.4 million and net proceeds of $207.4 million
Fourth Quarter and Full Year 2020 Summary Financial Results
Cash, cash equivalents, restricted cash and marketable securities were $286.0 million as of December 31, 2020, compared to $101.3 million as of December 31, 2019. Arcutis believes that its current cash, cash equivalents and marketable securities of over $470 million, including the $207.4 million net proceeds from its recent financing, will be sufficient to fund its operations into 2023.
Research and development (R&D) expenses for the quarter ended December 31, 2020 were $27.4 million compared to $10.8 million for the corresponding period in 2019. R&D expenses for the year ended December 31, 2020 were $115.3 million compared to $36.5 million for the corresponding period in 2019. These year-over-year increases were primarily due to the initiation of multiple clinical trials during the last year.
General and administrative (G&A) expenses for the quarter ended December 31, 2020 were $6.7 million compared to $2.2 million for the corresponding period in 2019. G&A expenses for the year ended December 31, 2020 were $21.3 million compared to $6.6 million for the corresponding period in 2019. These year-over-year increases were primarily due to higher headcount and professional services costs, including the costs associated with being a public company.
Net loss was $34.0 million, or $0.79 per basic and diluted share, for the quarter ended December 31, 2020 compared to $12.6 million, or $6.13 per basic and diluted share, for the corresponding period in 2019. Net loss was $135.7 million, or $3.80 per basic and diluted share, for the year ended December 31, 2020 compared to $42.0 million, or $22.78 per basic and diluted share, for the corresponding period in 2019.
About Arcutis - Bioscience, applied to the skin.Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a late-stage biopharmaceutical company focused on developing and commercializing treatments for unmet needs in immune-mediated dermatological diseases and conditions, or immuno-dermatology. The company is leveraging recent advances in immunology and inflammation to develop differentiated therapies against biologically validated targets to solve persistent treatment challenges in serious diseases of the skin. Arcutis robust pipeline includes four novel drug candidates currently in development for a range of inflammatory dermatological conditions. The companys lead product candidate, topical roflumilast, has the potential to revitalize the standard of care for plaque psoriasis, atopic dermatitis, scalp psoriasis, and seborrheic dermatitis. For more information, visit https://www.arcutis.com or follow the company on LinkedIn and Twitter.
Forward Looking StatementsThis press release contains "forward-looking" statements, including, among others, statements regarding the potential for its topical drugs in development to address large markets with significant unmet need; expectations with regard to the timing of data events anticipated during 2021/2022; and the Companys belief that its current cash, cash equivalents and marketable securities, including the net proceeds from its recent financing, will be sufficient to fund its operations into 2023. These statements involve substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements and you should not place undue reliance on our forward-looking statements. Risks and uncertainties that may cause our actual results to differ include risks inherent in the clinical development process and regulatory approval process, the timing of regulatory filings, and our ability to defend our intellectual property. For a further description of the risks and uncertainties applicable to our business, see the Risk Factors section of our Form 10-K filed with U.S. Securities and Exchange Commission (SEC) on February 16, 2021, as well as any subsequent filings with the SEC. We undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.
Contact:Heather Rowe Armstrong Vice President, Investor Relations & Corporate Communicationsharmstrong@arcutis.com805-418-5006, Ext. 740
ARCUTIS BIOTHERAPEUTICS, INC.Balance Sheets(In thousands)
December 31,
2020
2019
ASSETS
Current assets:
Cash and cash equivalents
$
65,082
$
63,336
Restricted cash
1,542
Marketable securities
219,359
37,929
Prepaid expenses and other current assets
6,843
5,209
Total current assets
292,826
106,474
Property and equipment, net
2,016
227
Operating lease right-of-use asset
3,349
264
Other assets
78
47
Total assets
$
298,269
$
107,012
LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS EQUITY (DEFICIT)
Current liabilities:
Accounts payable
$
7,140
$
1,405
Accrued liabilities
15,462
3,654
Operating lease liability
178
Total current liabilities
22,602
5,237
Operating lease liability, noncurrent
4,964
129
Other long-term liabilities
82
184
Total liabilities
27,648
5,550
Convertible preferred stock
166,491
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HADLIMA (adalimumab injection) Now Available for the Treatment of Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic…
Posted: at 12:23 am
KIRKLAND, QC, Feb. 18, 2021 /CNW/ - Merck Canada Inc., an affiliate of Merck & Co., Inc., known as MSD outside the United States and Canada,announces today that HADLIMA is available and approved for the following indications:
HADLIMA is a fully human monoclonal antibody that binds to a specific protein called tumor necrosis factor (TNF-alpha), which is made by the body's immune system. People with RA, PsA, AS, CD, UC, HS or psoriasis have too much of TNF-alpha in their bodies.8 The presence of extra TNF-alpha in the body can attack normal healthy body tissues and cause inflammation, particularly in the bone, cartilage, joints, digestive tract and skin tissues. By binding to TNF-alpha, HADLIMA decreases the inflammation process of these diseases.9
Approximately six million (one in five) Canadians are living with arthritis, making it Canada's most prevalent chronic health condition.10 While there are many different subtypes of arthritis, inflammatory arthritis includes a group of conditions that impact the body's immune system. The most common forms of inflammatory arthritis are RA, AS and PsA.11
An estimated 270,000 Canadians live with inflammatory bowel disease (IBD), a group of disorders caused by inflammation in the intestines.12 The main forms of IBD are CD and UC.13 By 2030, the number of Canadians with IBD is expected to rise to 400,000 or approximately 1% of the population.14
It is estimated that over one million Canadians are currently living with HS, a chronic skin condition that causes lumps to appear in the folds of the skin.15 Psoriasis, also a chronic skin condition, affects approximately one million Canadians, and Ps affects approximately 90% of this patient population.16
Uveitis, an inflammatory disease that causes damage to the eye, causes about 20% of legal blindness. Every year, approximately 2% of the Canadian population is newly diagnosed with uveitis.17
"HADLIMA further expands Merck's portfolio of biosimilar treatments to address inflammatory and dermatological immune diseases," says AnnA Van Acker, President, Merck Canada. "We are very proud to bring more solutions and therapeutic choices to help improve the lives of Canadians with these chronic conditions."
About HADLIMA
HADLIMA is a biosimilar biologic drug (biosimilar) and authorized based on its similarity to HUMIRA. A biosimilar is a biologic drug that is highly similar to a biologic drug already authorized for sale.18 Biosimilars are assessed and approved by Health Canada against the same rigorous standards used to ensure the quality, efficacy and safety as in any other biologic drug.19 Biosimilars provide patients more treatment options to help manage their disease and symptoms.
Clinical efficacy and safety studies have been conducted in patients with RA to demonstrate clinical comparability between HADLIMA and HUMIRA. The extrapolation of these data to support uses of HADLIMA in IBD is based on the demonstrated comparability, in terms of product quality, non-clinical, human pharmacokinetic and clinical characteristics. Randomized clinical trials have not been conducted to compare HADLIMA to HUMIRA in patients with JIA, PsA, AS, adult CD, UC, HS, Ps, and adult uveitis.22
The types, frequency and severity of adverse events were comparable between HADLIMA and HUMIRA in the RA clinical trial. The most common expected adverse reactions with HADLIMA are injection site reactions and cough and cold symptoms. It should not be administered to patients with severe infections such as sepsis and tuberculosis. HADLIMA contains a Boxed Warning to alert health care professionals and patients about an increased risk of hepatosplenic T-cell lymphoma (HSTCL), a rare, serious lymphoma that is often fatal, which has been identified in patients treated with adalimumab injection. The Boxed Warning also notes allergic reactions, other cancers, lupus-like symptoms, nervous system diseases, serious infections and blood problems.
The Merck Harmony Patient Program provides free confidential patient-assistance services to patients who have been prescribed HADLIMA (adalimumab injection). To learn more visit MerckHarmony.ca.
About Merck
For more than 125 years, Merck, known as MSD outside of the United States and Canada, has been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases in pursuit of our mission to save and improve lives. We demonstrate our commitment to patients and population health by increasing access to health care through far-reaching policies, programs and partnerships. Today, Merck continues to be at the forefront of research to prevent and treat diseases that threaten people and animals including cancer, infectious diseases such as HIV and Ebola and emerging animal diseases as we aspire to be the premier research-intensive biopharmaceutical company in the world.
In Canada, Merck markets a broad range of vaccines, pharmaceutical and animal health products and is one of the top R&D investors in Canada, with investments totaling $89 million in 2019 and more than $1.3 billion since 2000. Basedin Kirkland, Qubec, Merck employs approximately 650 people across the country. For more information about our operations in Canada, visit http://www.merck.ca and connect with us on YouTube and Twitter @MerckCanada.
Forward-Looking Statement of Merck & Co., Inc., Kenilworth, N.J., USA
This news release of Merck & Co., Inc., Kenilworth, N.J., USA (the "company") includes "forward-looking statements" within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company's management and are subject to significant risks and uncertainties.If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.
Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company's patents and other protections for innovative products; and the exposure to litigation, including patent litigation and/or regulatory actions.
The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company's 2017 Annual Report on Form 10-K and the company's other filings with the Securities and Exchange Commission (SEC) available at the SEC's Internet site (www.sec.gov).
Please see the product monograph for HADLIMA (adalimumab injection) at: https://www.merck.ca/static/pdf/HADLIMA-PM_E.pdf
References
______________________________
1HADLIMA Product Monograph. Merck & Co. Inc. November 2020.
2The Arthritis Society. The Truth About Arthritis. Available at: https://arthritis.ca/about-arthritis/what-is-arthritis/the-truth-about-arthritis#:~:text=Today%206%20million%20Canadians%20have,to%20have%20arthritis%20than%20men. Accessed on February 16, 2021.
3Crohn's and Colitis Canada. Resources and Publications. Available at: https://crohnsandcolitis.ca/About-Us/Resources-Publications/Impact-of-IBD-Report. Accessed on February 16, 2021.
4The Canadian Skin Patient Alliance. Hidradenitis Suppurativa. Available at: https://www.canadianskin.ca/hidradenitis-suppurativa#:~:text=Overview%20%2D%20What%20is%20HS,-Hidradenitis%20Suppurativa%20(HS&text=Lumps%20that%20are%20close%20together,out%20a%20dermatologist%20for%20help. Accessed on February 16, 2021.
5Canadian Dermatology Association. Psoriasis. Available at: https://dermatology.ca/public-patients/skin/psoriasis/. Accessed on February 16, 2021.
6Fighting Blindness Canada. Uveitis. Available at: https://www.fightingblindness.ca/eye-diseases-pathways/uveitis/. Accessed on February 16, 2021.
7HADLIMA Product Monograph. Merck & Co. Inc. November 2020.
8HADLIMA Product Monograph. Merck & Co. Inc. November 2020.
9HADLIMA Product Monograph. Merck & Co. Inc. November 2020.
10The Arthritis Society. The Truth About Arthritis. Available at: https://arthritis.ca/about-arthritis/what-is-arthritis/the-truth-about-arthritis#:~:text=Today%206%20million%20Canadians%20have,to%20have%20arthritis%20than%20men. Accessed on February 16, 2021.
11The Arthritis Society. Inflammatory arthritis. Available at: https://arthritis.ca/about-arthritis/arthritis-types-(a-z)/types/inflammatory-arthritis#:~:text=The%20most%20common%20forms%20of,ankylosing%20spondylitis%20and%20psoriatic%20arthritis. Accessed on February 16, 2021.
12Crohn's and Colitis Canada. Resources and Publications. Available at: https://crohnsandcolitis.ca/About-Us/Resources-Publications/Impact-of-IBD-Report. Accessed on February 16, 2021.
13Crohn's and Colitis Canada. 2018 Impact of Inflammatory Bowel Disease In Canada. Available at: https://crohnsandcolitis.ca/Crohns_and_Colitis/documents/reports/2018-Impact-Report-LR.pdf. Accessed on February 16, 2021.
14Crohn's and Colitis Canada. Resources and Publications. Available at: https://crohnsandcolitis.ca/About-Us/Resources-Publications/Impact-of-IBD-Report. Accessed on February 16, 2021.
15The Canadian Skin Patient Alliance. Hidradenitis Suppurativa. Available at: https://www.canadianskin.ca/hidradenitis-suppurativa#:~:text=Overview%20%2D%20What%20is%20HS,-Hidradenitis%20Suppurativa%20(HS&text=Lumps%20that%20are%20close%20together,out%20a%20dermatologist%20for%20help. Accessed on February 16, 2021.
16Canadian Dermatology Association. Psoriasis. Available at: https://dermatology.ca/public-patients/skin/psoriasis/. Accessed on February 16, 2021.
17Fighting Blindness Canada. Uveitis. Available at: https://www.fightingblindness.ca/eye-diseases-pathways/uveitis/. Accessed on February 16, 2021.
18Government of Canada. Biosimilar Biologic Drugs in Canada: Fact Sheet. Available at: https://www.canada.ca/en/health-canada/services/drugs-health-products/biologics-radiopharmaceuticals-genetic-therapies/applications-submissions/guidance-documents/fact-sheet-biosimilars.html. Accessed on February 16, 2021.
19Government of Canada. Biosimilar Biologic Drugs in Canada: Fact Sheet. Available at: https://www.canada.ca/en/health-canada/services/drugs-health-products/biologics-radiopharmaceuticals-genetic-therapies/applications-submissions/guidance-documents/fact-sheet-biosimilars.html. Accessed on February 16, 2021.
SOURCE Merck Canada
For further information: Media Contacts: Merck Canada Media Relations, 1-833-906-3725; Alannah Nugent, 647-458-3867
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Olivia Bowen shares snaps of psoriasis as she tells how condition has improved – OK! magazine
Posted: at 12:23 am
Olivia Bowen has shared before and after snaps of her psoriasis in a candid Instagram post.
The Love Island star, 27, was diagnosed with the skin condition when she was 17.
In her post she proudly revealed the patches across her stomach and chest have improved thanks to prescription cream.
In her post, the excited reality TV star, wrote: "Progress!!! Last week they were sooo raised, angry, red & itchy [sic].
"A week on and they're becoming lighter & less angry! I went to the doctors & was prescribed cream So fingers crossed!"
Alex Bowen's wife also shared a snap of the current state of her abs.
Updating fans who are unaware of her condition, she explained: "A few of you catching up, this is called guttate psoriasis.
"I have had it a couple times before, I've had it like this (all over my body head to toe] once before when I was 17. It usually stays with me around 3/4 months. Some days it's horrible & painful & makes me feel terribly insecure.
"Other days I pick myself up & remind myself there are many many things worse than a wee skin condition, and that's what I hold onto! It's just skin, who I am is important [sic]."
She also shared that she wouldn't be revealing the name of her prescription cream.
Olivia added: "It is prescribed & very strong so it would be irresponsible for me to suggest out to everyone & anyone.
"All I can say is definitely definitely contact your doctors and go throughout them. It really is worth it, it's not embarrassing, it'll help [sic]."
Last month Olivia reached out on social media to ask her followers to help her find a sun bed which she says will stop her psoriasis from spreading all over her body.
The Love Island star asked her fans for recommendations for UVB light sun beds as she revealed using them was the only thing that helped her psoriasis when she was a teenager.
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Facebook censors Ron Paul – New York Post
Posted: at 12:21 am
Former Texas congressman Ron Paul says hes been blocked from using his Facebook page for unspecified violations of community standards as Big Tech purges users following last weeks Capitol riot.
Paul, a libertarian leader and critic of President Trump, tweeted a screenshot of his temporarily restricted Facebook page.
With no explanation other than repeatedly going against our community standards, @Facebook has blocked me from managing my page. Never have we received notice of violating community standards in the past and nowhere is the offending post identified, Paul tweeted.
His most recent post linked to an article he wrote denouncing shocking and chilling censorship on social media.
Paul, 85, unsuccessfully ran for the GOP presidential nomination in 2008 and 2012 as an anti-war, pro-civil liberties candidate. His son is Sen. Rand Paul (R-Ky.), who opposed Trumps request to overturn President-elect Joe Bidens electoral win and called Trumps pre-riot speech irresponsible.
In response to his father being censored, Sen. Paul tweeted, Facebook now considers advocating for liberty to be sedition. Where will it end?
Facebook did not immediately respond to a request for comment.
Although his son sought to work with and influence Trump, the elder Paul remained an often fiery critic. He opposed Trumps foreign and immigration policies, and said a Mexico border wall might be used for keeping us in. He mused about Trump being vulnerable to a challenge in 2020.
Some civil libertarians are concerned about fallout from the Capitol riot, which disrupted but did not prevent certification of Bidens victory.
Since the violence on Capitol Hill, which killed four Trump supporters and a policeman, Twitter, Facebook, Google, Apple and Amazon have moved to limit the reach of Trumps supporters and alleged conspiracy theorist accounts.
Twitter permanently banned Trump on Friday after Facebook said he would lose control of his account through at least Bidens inauguration on Jan. 20. As Trump supporters migrated to free speech social network Parler, Apple and Google yanked the app and Amazon dropped its hosting of the platform.
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Brian Dozier, an All-Star for the Twins, retires at 33 – Minneapolis Star Tribune
Posted: at 12:21 am
FORT MYERS, Fla. Whenever a popular Twins player from Brad Radke, Joe Nathan, Michael Cuddyer, Torii Hunter, through the M & M boys has a retirement news conference, the organization turns out in force.
The Zoom version of that occurred Thursday when Brian Dozier, 33, announced his retirement after nine seasons, including seven with the Twins. Dozier wore a perpetual grin on his face as Ron Gardenhire, Paul Molitor, Eduardo Escobar, Terry Ryan, Josh Willingham and even clubhouse major-domo Rod McCormick appeared on screen to wish No. 2 a happy retirement.
"You know how much I respect you, man," said Escobar, who got out of a Diamondbacks team meeting to congratulate Dozier. "You [taught] me [how to] play this game the right way, man. That's why I'm still here."
Escobar was the teammate who experienced good times and endured bad times with Dozier's help. Gardenhire was the manager who told Dozier to stop taking ground balls at shortstop after his rookie season when the Twins made him their full-time second baseman. Molitor was the manager who benefited when Dozier unlocked his power, blasting 42 home runs in 2016 the only Twin other than Harmon Killebrew and Nelson Cruz to reach 40 in a season.
"In addition to that performance, it was just how you took care of your teammates and made everybody better," Molitor said. "You were never selfish about anything that you do."
Of the 192 home runs Dozier hit in his career, 167 came as a second baseman for the Twins, a club record. He hit 127 home runs from 2014-17, sixth most in the American League.
Brian Dozier career statistics
He was traded to the Dodgers in July of 2018, playing in 47 games. In 2019, he signed as a free agent with the Nationals, who shook off a terrible start to win the World Series, but he only hit .238 during the season and went 0-for-6 in the postseason. After a brief stint in the Padres organization, Dozier signed with the Mets in July of 2020 but only played in seven games before being released a month later, and he began to realize his time might be up. After thinking about retiring during the offseason, he made it official Thursday.
"I was blessed, so blessed to be able to play for such good managers and general managers throughout my career and some people I respect forever and call them friends forever," Dozier said. "I played for some great organizations and so I appreciate all of you."
Gardenhire, of course, flashed his trademark humor while saluting Dozier.
"One of the nicest people I've ever been around in my life and really just thoroughly enjoyed watching him grow as a player," Gardenhire said, "and of course, after I left, he started hitting bombs all in the seats."
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Fact Check: Did the Biden Administration Remove the White House Petitioning System? – Newsweek
Posted: at 12:21 am
At his inauguration, President Joe Biden pledged to restore democracy and declared that the will of the people had been heard. But his detractors are now pointing to an allegedly missing page from the White House website as evidence against these proclamations.
"We the People," an online petitioning system launched by President Barack Obama's administration, is said to have been removed without explanation.
On Tuesday, the Ron Paul Institute, responding to an article published by the anti-imperialist website antiwar.com, decried the Biden administration for allegedly taking down a White House petitioning system that allowed citizens to start campaigns. Once the campaigns reached at least 100,000, the White House was required to respond.
"It appears that the 'We the People' petition system has been taken off the White House website," the Ron Paul Institute posted to its blog. "This is a terrible event, and it must be publicized, and Biden must be made to reverse this decision."
In 2011, the Obama White House debuted a new section of whitehouse.gov where users could create, browse and sign online petitions that, under most circumstances, would require a government response once they reached 100,000 signatures.
Criminal proceedings and many federal processes were exempt from this, and the platform functioned mainly as a public relations tool for citizens to express themselves and communicate their concerns to the White House. Many petitions were created tongue-in-cheek, and some might remember a playful 2012 petition for the federal government to create a Death Star as an economy-driving enterprise.
When President Donald Trump took office in 2017, his administration removed the "We the People" page, sparking outrage and media response. The Washington Post reported that several petitions demanding Trump release his tax returns and resign reached well over 100,000 signatures before the page was removed with a note saying it was undergoing maintenance.
Eventually, the petitioning system returned, but the page disappeared the day of Biden's inauguration. Previous links redirect to the White House homepage.
The White House did not respond to requests for comment Wednesday regarding the reason for the page's removal or whether the petitioning system would return. Archives of the page from previous administrations still are accessible.
True.
The "We the People" system is nowhere to be found on the White House website. The reason behind its removal has not been released.
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THIS, THAT AND THE OTHER: A Buccaneers connection, and a Super Bowl party that (almost) wasnt – Wicked Local
Posted: at 12:21 am
Beata Cook| Wicked Local
Hi Folks. Once I get an idea for the week's topic, sometimes the words start to flow effortlessly until I realize I'm running out of space. At other times, I have to push myself to get the column ready to hand over to Avis for typing, proofreading, and small edits before it's sent to the editor of the Banner. That's where I find myself today, Monday, Feb. 8.
First of all, yesterday (the day of the Super Bowl, of all days) got all screwed up, which set me up for a very poor night's sleep, and as a consequence I could easily take a nap right now. But time grows short so I shall force myself to continue to follow my trend of thought wherever it might lead and hope my readers aren't overcome by my lethargy.
Back to the annual Super Bowl played by the champion teams of the NFL football season, which was won for many years by our New England Patriots, led by our quarterback, Tom Brady. Tom, at age 43, is considered kind of long in the tooth for a professional football player, but for some unknown reason he opted to go on playing but with a different team. Happily for me, he picked a team with which I feel a sort of connection, the Tampa Bay Buccaneers. You see, my younger brother Paul (who died about 16 years ago and to whom I was very devoted) had moved many years ago from Boston with his partner, Ron, to St. Petersburg, Florida. Soon after the move they became fans of the Buccaneers, but Paul's team of choice always remained the Patriots. I still have a stadium blanket which the boys sent me years ago, with the name Buccaneers printed on its pretty orange quilting. I treasure it to this day. My sister Marian, our Aunt Ruth and I spent our yearly winter vacations with Paul and Ron in St. Pete, and therein lies my connection. If Brady felt it necessary to move to another locale with a different team, what better choice than the Tampa Bay Buccaneers?
So it was that I and my nieces Sue and Cindy planned a Super Bowl celebration of our own on game day. Cindy, who works at Stop & Shop, ordered freshly fried chicken wings to be picked up at the designated hour. Our neighbor, Mark Bove, contributed homemade pizza. Our plans were to do our weekly grocery shopping, put the stuff away, pick up the chicken wings and sit down to enjoy the game. Alas, that was not to be!
Was it Robert Burns who said, The best laid plans of mice and men often go awry ?
Disappointment #1: When Cindy arrived, she announced that the machine which fries the Stop & Shop chicken wings had burned out and would need repairs. As an alternative, we decided on frozen chicken wings accompanied by potato skins such as we once devoured at the now- defunct Pucci's. After we got the groceries sorted and put where they belong, we were really looking forward to sitting down with a drink and a piece of Mark's pizza as we watched the opening ceremonies of the Super Bowl.
Then came Disappointment #2. It was just about this time that I lost my picture on my Direct TV hookup. Since this has happened in the past during bad weather, I wasn't overly concerned.
Usually when it goes down, the screen delivers a message stating that the satellite dish is not relaying a signal but that they are searching and the connection would be restored shortly. But that's not what happened this time!
Susie got in touch with Direct TV customer service, and though she is much more experienced with technology than I am, after a series of unplug this, plug in that she was still unable to get a picture. Frustrated, Cindy and I had a piece of Mark's pizza but Susie did not. She said she didn't feel well and wasn't hungry. Because Cindy had an early work schedule the next day, Susie put the frozen wings and potato skins in the oven for Cindy to take home for her supper and then continued the hopeless task of getting a picture on the TV. She got so involved she forgot about the food in the oven, and when I reminded her, it was too late. The food was dry and tasteless, but before Cindy left for home she gamely ate hers anyway and said that it wasn't too bad.
What she deemed not too bad was Disappointment #3 for me, as far as I was concerned.
With the game well underway, Susie finally located a radio station on which she could follow the action and scores. Because football is such a visual game and my hearing is so impaired, there really isn't much pleasure in a radio broadcast. But when we turned it on the Buccaneers were in the lead after a couple of touchdowns by Rob Gronkowski, also a former Patriots player.
Finally, even better news arrived when Susie noticed that a light usually showing on the converter box wasn't shining. With that she started fooling around with plugs and outlets once again when, lo and behold, the screen suddenly came to life, informing us that they had almost located the signal on my disc and we should be connected in a few minutes. It was now halftime and I was hungry and tired, but we were able to see the last half of the game as well as the celebration when the Buccaneers handily won the Super Bowl! Brady will get his seventh ring.
It was then that my thoughts turned to my deceased loved ones, Paul, Marian, and friend Ron who have all gone on to another place, but I was able to join them in spirit as I shouted,
YIPPEE!
We won another Super Bowl. Not only did Tom Brady win one for the Buccaneers, but I finished my column with no space to spare!
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THIS, THAT AND THE OTHER: A Buccaneers connection, and a Super Bowl party that (almost) wasnt - Wicked Local
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Labyrinths: The Films of Milla Jovovich and Paul WS Anderson – Los Angeles Review of Books – lareviewofbooks
Posted: at 12:21 am
FEBRUARY 18, 2021
LATE IN RESIDENT EVIL (2002), an amnesiac security officer named Alice (Milla Jovovich) kicks a zombie dog in the face. It is a moment of Proustian self-realization, the undead canine a drooling madeleine that triggers memories of her role in the multinational boogeyman known as the Umbrella Corporation. This emergence of Alice-as-superhero signaled the beginning of an unlikely franchise, and the personal and professional collaboration between Jovovich and director Paul W. S. Anderson, who married in 2009. They have worked closely together on female-fronted action movies of sleek and brutal intelligence, with Anderson building elaborately detailed labyrinths that Jovovich determinedly destroys. Together, they have charted the subterranean postapocalyptic corridors of the Resident Evil franchise; the steampunk Paris of their The Three Musketeers (2011) rethink; and the desert battlegrounds of their latest video game adaptation, Monster Hunter (2020). It is one of the most fruitful collaborations in contemporary action cinema, as inventive as Christopher McQuarrie and Tom Cruise on the Mission: Impossible franchise or Chad Stahelski and Keanu Reeves on John Wick. Regrettably, Anderson and Jovovich are often overlooked due to the critically reviled nature of video game movies.
Jovovichs Alice was not a part of the Resident Evil video game series, but an Alice in Wonderlandinspired invention that allowed Anderson and his longtime producer Jeremy Bolt to stray from the games convoluted mythology. With no guarantee of a sequel, they couldnt spend much time on world-building. Instead, they churned out a controlled piece of survival horror taking place almost entirely in The Hive, Umbrella Corporations down-the-rabbit-hole underground lab.
Resident Evil was the first screenplay Anderson had written since his debut feature, Shopping (1994), a violent youth-in-revolt dystopia starring a dewy Jude Law and his then-wife Sadie Frost. During one of their joy rides, Frost plays Crazy Cars, a handheld video game. From the start, Anderson demonstrates his interest in how virtual worlds can be more truthful than reality. In his features, surfaces are deceptive: something propped up by a repressive regime like Umbrella, and it is the virtual space, the world within or behind the visible, where societys subjugation is revealed. Anderson grew up in Northeast England, in the crumbling post-industrial town of Newcastle upon Tyne, and his films are usually set in modern structures gone to seed, left to rot by a fascistic authority. Shoppings London is a smoke-belching wasteland; Event Horizon (1997) is set on an abandoned, seemingly decrepit spaceship; and Resident Evil turns a modern glass-testing facility into a bloodbath.
For his next project, Anderson was hired to adapt and direct the feature film of Mortal Kombat, based on the arcade smash he used to play as a college student. He wanted it to be a combination of Bruce Lee and Robert Clouses 1973 Enter the Dragon and Don Chaffeys 1963 Jason and the Argonauts, with its stop-motion six-armed monster. Under the guidance of Hong Kong fight expert Robin Shou, the film hit its throwback mark, becoming a box office hit. Despite fan disappointment that George A. Romero wasnt hired to make Resident Evil (he wrote a script that the studio rejected), Anderson was the logical choice.
On Resident Evil, their first film together, Anderson shunts Jovovichs Alice down a corporate rabbit hole to an underground Umbrella facility that produces the T-Virus, an experimental weapon that happens to turn dour government types into drooling zombie brain-eaters. Aided by a brusque security team and an enigmatic artificial intelligence named the Red Queen, Alice tries to lead the ragtag group back to the surface. Operating more like a locked-room thriller than a gruesome zombie splatter fest, Anderson kept costs down, completing the film for a comparatively slight $33 million with the help of the German production company Constantin Film.
Jovovich has been in front of cameras since starting a modeling career at the age of 12 and has a keen knowledge of how to utilize her body as a weapon. Up until the age of five, she lived in the Soviet Union with her mother (actress Galina Loginova) and father (Bogich Jovovich). Her family emigrated to London and ended up in Los Angeles, where her parents cobbled together a living doing housework, including cooking and cleaning for writer-director Brian De Palma. When Bogich was imprisoned for participating in a health insurance scam, mother and daughter had to fend for themselves. Galina, a successful actor in Russia, started coaching Milla for a life in front of the camera. As a teenager, Milla was supporting her family by modeling for fashion photographer Herb Ritts. Jovovich told Purple Magazine that, as a kid, she liked reading Japanese comics and seeing ninjas swooping from tree to tree. I wanted to have that kind of control over my body, the kind dancers and martial artists have. It fascinated me.
Jovovich did not receive an opportunity to explore that physicality on screen until she was cast in Luc Bessons The Fifth Element (1997), which she credits as the turning point in her film career. She had appeared in films before, but only as eye candy, like her shipwrecked teen in Return to the Blue Lagoon (1991) or her hippie chick in Dazed and Confused (1993). The Fifth Elements Leeloo was something else: a divine alien naf with martial arts skills. She played her like a baby bird who could lash out if threatened: jittery, wide-eyed, and limber. This ability to seem otherworldly, while being able to handle the athleticism necessary for many of the stunts, made her a natural Alice.
Jovovich took the Resident Evil job on a lark, since her brother was a fan of the games. She was upset after reading revised versions of the script, though, which handed off many of the action scenes to her co-star Michelle Rodriguez, who was fresh off of The Fast and the Furious (2001). Jovovich told The Guardian that she stormed into Andersons hotel room and threatened to leave the project. Instead, they spent four hours going over the script together, line by line, giving her back the scene where she runs up a wall, scissor-kicks the mutant dog, and breaks the neck of the zombie by crushing his head between her thighs. An athletic, commanding presence, Jovovich wanted to take center stage, and Anderson was happy to cede it to her. This impromptu rewrite would become the model for their working relationship.
Anderson obsessively maps underground tunnels and corridors in his films, and Jovovich is his willing avatar, able to conquer these torturous constructions the explorer to his cartographer. Andersons family worked in coal mining. He told The New York Times about the lure of going down there into the dark. Its in my blood. My grandfather, who brought me up, was a coal miner. I visited the mines with him. I remember it vividly. It was horrible. Im glad I didnt go into the family business. He could never get away from the imagery, though, admitting to Cinematical,
I cant remember who it was now, probably some other French filmmaker, said that there are two kinds of filmmakers there were farmers and miners. Farmers every year would grow different crop in their fields, right? One year it would be wheat; the next, it would be corn, so those are the directors that go make a comedy and they go make a drama and they go make a horror movie. And then there are those who are miners, and all theyre interested in is gold. They just dig on one seam, and I guess Im a miner.
As a result, CG schematics are a familiar image in the Resident Evil series, an aid to orient the viewer in the franchises labyrinthine spaces. Anderson wrote and produced all six Resident Evil movies, but only directed four of them: Resident Evil, Afterlife, Retribution, and The Final Chapter. Yet, through each installment of the franchise, Anderson establishes destination as destiny knowing where you are going is the only way to survive.
The series utilizes diverse landscapes to change the direction and texture of each journey. Resident Evil is an underground lair, with Alice surging upward. Resident Evil: Apocalypse (2004, directed by Alexander Witt) takes place in the ravaged urban space of Raccoon City, with Alice ranging horizontally out of the locked-down metropolis. Resident Evil: Extinction (2007, directed by Russell Mulcahy) takes place in the desert and she must travel downward, back underground to find another of Umbrellas secret labs. Resident Evil: Afterlife (2010) ranges in the sky to the Pacific Northwest and down into the sewers of a Los Angeles prison.
Resident Evil: Retribution (2012) is an amalgam of the previous four, taking place in a testing facility that simulates T-virus breakouts, infecting replicas of Tokyo, New York City, Moscow, and a suburb of Raccoon City. Alices travels through these simulacra create the illusion of movement when she is the one standing in place as the world dies around her. Resident Evil: The Final Chapter returns to The Hive from the first film and mimics its upward trajectory, but in casting their daughter Ever Anderson as the Red Queen, it turns the films climactic apocalypse sequence into an improbably moving vision. Alice turns out to be a clone of a sick child that the Red Queen was modeled on. As a final gift, the Red Queen gives Alice the childs memories to keep as her own, to fill the gap in time before Alice was created. This is rendered visually in real home videos of Ever growing up, as Jovovichs eyes well up with tears. This bloody zombie franchise all of a sudden becomes a documentary expression of a familys love.
The Three Musketeers is the first film Anderson and Jovovich made together outside of the Resident Evil universe, and it is a film of dizzying verticality. From a purely visual standpoint, it is their most beautiful collaboration, as they secured permission to film in Bavarian castles commissioned by King Ludwig II, ornate Neo-Baroque in style, modeled after Versailles. Anderson indulges his inner cartographer by installing a floor map inside Cardinal Richelieus (Christoph Waltz) quarters, on which he deploys world armies like chess pieces. Milady de Winter (Jovovich) is a duplicitous double agent who plays Richelieu against the British Duke of Buckingham (Orlando Bloom). Jovovich again fills out her role to include a few spectacular fight scenes, including a jewel robbery that features sword-fighting, safe-cracking, musketry, and a soupon of base diving. Her big dive sets up an even more death-defying one later, as Da Vincidesigned airships cannonade each other in the clouds. It is a supporting performance, but a bravura one.
Over the years, Anderson has grown as a nimble director of fight sequences, keenly attentive to spatial clarity, but his collaborations with Jovovich are always the most physically dynamic and innovative. Working with Jovovich has expanded the possibilities of violence in his films. Jovovich is a relentless trainer who loves to fight, and she weighs in on the details. The viewer can witness her thinking during each bout, planning every counter, and Anderson ensures each punch lands inside his rigidly defined spaces. This perfectionism is present even in the timbre of her voice she demanded to rerecord all of her lines in Apocalypse to lower the pitch of her voice and give Alice more of a Dirty Harry menace.
According to director of photography Glen MacPherson (Andersons DP since Resident Evil: Afterlife), Jovovich does lots of her own stunts and
does a lot of modeling still, so she knows about light, and if Im in a tricky situation, shell stand there on the mark for 10 minutes just to help me out. [] She trains for weeks before the production, for all those fight scenes. She has to get into harnesses, and they pull her up in ropes and pulleys and things. And working with the fight choreography, I dont know how they remember that stuff. Its like pretty elaborate dance moves, you have to be at the right place at the right time.
Anderson is one of the few Hollywood directors to fully embrace the possibilities of 3D film, so Jovovich must be more precise with her movements. MacPherson said that in 3D, punches must brush their nose with your fist, or else you can see the gap. It is a matter of precision and trust, qualities the duo have built up over their decade of working together.
2020s Monster Hunter gives Anderson and Jovovich an enormous sandbox to play in, a South African desert standing in for an alien landscape populated by massively scaled monsters, taken from the blockbuster Capcom game. Anderson treats the locations as levels for Jovovich to conquer, as her UN military squad travels (with the help of a combative Tony Jaa and a swashbuckling Ron Perlman) from the quicksand of the burrowing horned Diablos; to the cave of the Nerscylla mega-spiders; to, finally, the vaulting mountains, the stage of a climactic boss battle with the dragonlike Rathalos. Video game critics have been impressed by how faithfully the film mimics the games style. But for a viewer who hasnt played it (like myself), the visual scheme feels like a Frank Frazetta painting come to life, with surging peaks bisected by giant flaming swords.
The Nerscylla battle is most emblematic of the Anderson-Jovovich aesthetic, staged in an underground lair from which Jovovich surges upward in the dark, scattering pus-filled spider spores as she scrambles from darkness to light. It represents the elemental pleasures of their cinema, two artists honing what they each do best: constructing a grotesque dystopian world that a hard-bitten female annihilates with desperate fury.
Monster Hunter received a doomed theatrical release at the end of the pandemic-ravaged 2020 and was further set back by an insensitive pun that offended Chinese audiences, requiring it to be briefly pulled from that countrys theaters. As an international co-production partly funded by Chinese money (Tencent Pictures), this was an economic deathblow, and the ending cliffhanger seems unlikely to net a sequel. The only thing certain for their future is that Paul W. S. Anderson will surely build a new world for Milla Jovovich to tear down, another expression of their mutual love of assured destruction.
R. Emmet Sweeney works for Kino Lorber, Inc. producing DVDs and Blu-rays, and has written for Filmmaker Magazine,Film Comment, Turner Classic Movies, and NeoText.
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Ron Rudin’s Body Was Found & His Autopsy Revealed Details – Heavy.com
Posted: at 12:21 am
ABC News/Find a GraveMargaret Rudin/Ron Rudin
Ron Rudin was brutally murdered and his body was not found until years later when a fisherman stumbled across his charred remains. His wife, Margaret Rudin, was convicted of murder and served 20 years in prison. She became known as the Black Widow. His full name was Ronald Julian Rudin.
The couple had been married for seven years when Ron Rudin was shot in the back of the head with his own gun. Both Margaret and Ron had been married four times before their wedding. Margaret went on the run when the murder weapon was found in 1996, and she was indicted in 1997. Authorities also said Margaret Rudin tapped her husbands phone, suspecting he was having an affair.
Margaret Rudin, now 77, maintains her innocence. Rudin spoke out in exclusive interviews featured on ABC 20/20. The new episode, Five Weddings and a Murder, airs at 9 p.m. Eastern time Friday, February 21, 2021.
Heres what you need to know:
Ron Rudins body was found about 45 miles from Las Vegas, near the shoreline of a Colorado River Reservoir. Fisherman stumbled upon his remains, which included a skull and some charred bones. A decorative bracelet, which said RON in jewels, was also found in the area.
Prosecutors said at the Black Widow trial Rudin was shot in the head as he slept. They said his body was taken away in a truck, burned and dumped in the desert, according to the Associated Press.
Police determined Rudin was shot multiple times with a .22-caliber gun with a silencer. It was Rons own gun that was used to kill him. He had reported the gun missing just one year after he and Margaret were married. In addition to burning the body, Las Vegas Police and an autopsy determined he had been decapitated, according to the Las Vegas Sun.
Police believe Rudin was after her husbands property, which had an estimated $11 million worth. Police alleged Rudin shot her husband in their bed. They believe she had an accomplice, who was never identified. That person, they believe, helped her put the body into an antique humpback trunk and discard the body in the desert. The remains were found in 1995 at Nelsons Landing near Lake Mojave and the Colorado River.
Ron Rudin was murdered December 18, 1994 when he was 64 years old. He was buried at Saint Paul Lutheran Cemetery in Dieterich, Illinois, according to Find a Grave.
A diver found the weapon used in Ron Rudins murder at the bottom of Lake Mead in 1996. That sent Margaret Rudin on the run, several weeks before she was indicted on murder charges in 1997. She was arrested in Massachusetts in 1999.
Ron Rudin was a millionaire who earned his wealth as a prominent real estate developer in Las Vegas. Margaret Rudin was an antique shop owner and a socialite. She was arrested in Revere, Massachusetts after a tip was called in following a most wanted TV show. She had been living there for a year with a retired firefighter who she met among a group of retirees in Mexico.
I want to be exonerated, she told the Las Vegas Review-Journal. She said she wants a passport, to vote and to be able to do all the things that I was able to do before Ron was murdered.
I did not do it, she added.
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Ron Rudin's Body Was Found & His Autopsy Revealed Details - Heavy.com
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