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Human genetics | Description, Chromosomes, & Inheritance
Posted: January 31, 2023 at 5:32 pm
human genetics, study of the inheritance of characteristics by children from parents. Inheritance in humans does not differ in any fundamental way from that in other organisms.
The study of human heredity occupies a central position in genetics. Much of this interest stems from a basic desire to know who humans are and why they are as they are. At a more practical level, an understanding of human heredity is of critical importance in the prediction, diagnosis, and treatment of diseases that have a genetic component. The quest to determine the genetic basis of human health has given rise to the field of medical genetics. In general, medicine has given focus and purpose to human genetics, so the terms medical genetics and human genetics are often considered synonymous.
A new era in cytogenetics, the field of investigation concerned with studies of the chromosomes, began in 1956 with the discovery by Jo Hin Tjio and Albert Levan that human somatic cells contain 23 pairs of chromosomes. Since that time the field has advanced with amazing rapidity and has demonstrated that human chromosome aberrations rank as major causes of fetal death and of tragic human diseases, many of which are accompanied by intellectual disability. Since the chromosomes can be delineated only during mitosis, it is necessary to examine material in which there are many dividing cells. This can usually be accomplished by culturing cells from the blood or skin, since only the bone marrow cells (not readily sampled except during serious bone marrow disease such as leukemia) have sufficient mitoses in the absence of artificial culture. After growth, the cells are fixed on slides and then stained with a variety of DNA-specific stains that permit the delineation and identification of the chromosomes. The Denver system of chromosome classification, established in 1959, identified the chromosomes by their length and the position of the centromeres. Since then the method has been improved by the use of special staining techniques that impart unique light and dark bands to each chromosome. These bands permit the identification of chromosomal regions that are duplicated, missing, or transposed to other chromosomes.
Micrographs showing the karyotypes (i.e., the physical appearance of the chromosome) of a male and a female have been produced. In a typical micrograph the 46 human chromosomes (the diploid number) are arranged in homologous pairs, each consisting of one maternally derived and one paternally derived member. The chromosomes are all numbered except for the X and the Y chromosomes, which are the sex chromosomes. In humans, as in all mammals, the normal female has two X chromosomes and the normal male has one X chromosome and one Y chromosome. The female is thus the homogametic sex, as all her gametes normally have one X chromosome. The male is heterogametic, as he produces two types of gametesone type containing an X chromosome and the other containing a Y chromosome. There is good evidence that the Y chromosome in humans, unlike that in Drosophila, is necessary (but not sufficient) for maleness.
A human individual arises through the union of two cells, an egg from the mother and a sperm from the father. Human egg cells are barely visible to the naked eye. They are shed, usually one at a time, from the ovary into the oviducts (fallopian tubes), through which they pass into the uterus. Fertilization, the penetration of an egg by a sperm, occurs in the oviducts. This is the main event of sexual reproduction and determines the genetic constitution of the new individual.
Human sex determination is a genetic process that depends basically on the presence of the Y chromosome in the fertilized egg. This chromosome stimulates a change in the undifferentiated gonad into that of the male (a testicle). The gonadal action of the Y chromosome is mediated by a gene located near the centromere; this gene codes for the production of a cell surface molecule called the H-Y antigen. Further development of the anatomic structures, both internal and external, that are associated with maleness is controlled by hormones produced by the testicle. The sex of an individual can be thought of in three different contexts: chromosomal sex, gonadal sex, and anatomic sex. Discrepancies between these, especially the latter two, result in the development of individuals with ambiguous sex, often called hermaphrodites. Homosexuality is unrelated to the above sex-determining factors. It is of interest that in the absence of a male gonad (testicle) the internal and external sex anatomy is always female, even in the absence of a female ovary. A female without ovaries will, of course, be infertile and will not experience any of the female developmental changes normally associated with puberty. Such a female will often have Turner syndrome.
If X-containing and Y-containing sperm are produced in equal numbers, then according to simple chance one would expect the sex ratio at conception (fertilization) to be half boys and half girls, or 1 : 1. Direct observation of sex ratios among newly fertilized human eggs is not yet feasible, and sex-ratio data are usually collected at the time of birth. In almost all human populations of newborns, there is a slight excess of males; about 106 boys are born for every100 girls. Throughout life, however, there is a slightly greater mortality of males; this slowly alters the sex ratio until, beyond the age of about 50 years, there is an excess of females. Studies indicate that male embryos suffer a relatively greater degree of prenatal mortality, so the sex ratio at conception might be expected to favour males even more than the 106 : 100 ratio observed at birth would suggest. Firm explanations for the apparent excess of male conceptions have not been established; it is possible that Y-containing sperm survive better within the female reproductive tract, or they may be a little more successful in reaching the egg in order to fertilize it. In any case, the sex differences are small, the statistical expectation for a boy (or girl) at any single birth still being close to one out of two.
During gestationthe period of nine months between fertilization and the birth of the infanta remarkable series of developmental changes occur. Through the process of mitosis, the total number of cells changes from 1 (the fertilized egg) to about 2 1011. In addition, these cells differentiate into hundreds of different types with specific functions (liver cells, nerve cells, muscle cells, etc.). A multitude of regulatory processes, both genetically and environmentally controlled, accomplish this differentiation. Elucidation of the exquisite timing of these processes remains one of the great challenges of human biology.
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Human genetics | Description, Chromosomes, & Inheritance
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Genetic testing – Mayo Clinic
Posted: at 5:32 pm
Overview
Genetic testing involves examining your DNA, the chemical database that carries instructions for your body's functions. Genetic testing can reveal changes (mutations) in your genes that may cause illness or disease.
Although genetic testing can provide important information for diagnosing, treating and preventing illness, there are limitations. For example, if you're a healthy person, a positive result from genetic testing doesn't always mean you will develop a disease. On the other hand, in some situations, a negative result doesn't guarantee that you won't have a certain disorder.
Talking to your doctor, a medical geneticist or a genetic counselor about what you will do with the results is an important step in the process of genetic testing.
When genetic testing doesn't lead to a diagnosis but a genetic cause is still suspected, some facilities offer genome sequencing a process for analyzing a sample of DNA taken from your blood.
Everyone has a unique genome, made up of the DNA in all of a person's genes. This complex testing can help identify genetic variants that may relate to your health. This testing is usually limited to just looking at the protein-encoding parts of DNA called the exome.
Genetic testing plays a vital role in determining the risk of developing certain diseases as well as screening and sometimes medical treatment. Different types of genetic testing are done for different reasons:
Generally genetic tests have little physical risk. Blood and cheek swab tests have almost no risk. However, prenatal testing such as amniocentesis or chorionic villus sampling has a small risk of pregnancy loss (miscarriage).
Genetic testing can have emotional, social and financial risks as well. Discuss all risks and benefits of genetic testing with your doctor, a medical geneticist or a genetic counselor before you have a genetic test.
Before you have genetic testing, gather as much information as you can about your family's medical history. Then, talk with your doctor or a genetic counselor about your personal and family medical history to better understand your risk. Ask questions and discuss any concerns about genetic testing at that meeting. Also, talk about your options, depending on the test results.
If you're being tested for a genetic disorder that runs in families, you may want to consider discussing your decision to have genetic testing with your family. Having these conversations before testing can give you a sense of how your family might respond to your test results and how it may affect them.
Not all health insurance policies pay for genetic testing. So, before you have a genetic test, check with your insurance provider to see what will be covered.
In the United States, the federal Genetic Information Nondiscrimination Act of 2008 (GINA) helps prevent health insurers or employers from discriminating against you based on test results. Under GINA, employment discrimination based on genetic risk also is illegal. However, this act does not cover life, long-term care or disability insurance. Most states offer additional protection.
Depending on the type of test, a sample of your blood, skin, amniotic fluid or other tissue will be collected and sent to a lab for analysis.
The amount of time it takes for you to receive your genetic test results depends on the type of test and your health care facility. Talk to your doctor, medical geneticist or genetic counselor before the test about when you can expect the results and have a discussion about them.
If the genetic test result is positive, that means the genetic change that was being tested for was detected. The steps you take after you receive a positive result will depend on the reason you had genetic testing.
If the purpose is to:
Talk to your doctor about what a positive result means for you. In some cases, you can make lifestyle changes that may reduce your risk of developing a disease, even if you have a gene that makes you more susceptible to a disorder. Results may also help you make choices related to treatment, family planning, careers and insurance coverage.
In addition, you may choose to participate in research or registries related to your genetic disorder or condition. These options may help you stay updated with new developments in prevention or treatment.
A negative result means a mutated gene was not detected by the test, which can be reassuring, but it's not a 100 percent guarantee that you don't have the disorder. The accuracy of genetic tests to detect mutated genes varies, depending on the condition being tested for and whether or not the gene mutation was previously identified in a family member.
Even if you don't have the mutated gene, that doesn't necessarily mean you'll never get the disease. For example, the majority of people who develop breast cancer don't have a breast cancer gene (BRCA1 or BRCA2). Also, genetic testing may not be able to detect all genetic defects.
In some cases, a genetic test may not provide helpful information about the gene in question. Everyone has variations in the way genes appear, and often these variations don't affect your health. But sometimes it can be difficult to distinguish between a disease-causing gene and a harmless gene variation. These changes are called variants of uncertain significance. In these situations, follow-up testing or periodic reviews of the gene over time may be necessary.
No matter what the results of your genetic testing, talk with your doctor, medical geneticist or genetic counselor about questions or concerns you may have. This will help you understand what the results mean for you and your family.
Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.
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Genetic testing - Mayo Clinic
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Genetic Disorders: What Are They, Types, Symptoms & Causes
Posted: at 5:32 pm
OverviewWhat are genetic disorders?
Genetic disorders occur when a mutation (a harmful change to a gene, also known as a pathogenic variant) affects your genes or when you have the wrong amount of genetic material. Genes are made of DNA (deoxyribonucleic acid), which contain instructions for cell functioning and the characteristics that make you unique.
You receive half your genes from each biological parent and may inherit a gene mutation from one parent or both. Sometimes genes change due to issues within the DNA (mutations). This can raise your risk of having a genetic disorder. Some cause symptoms at birth, while others develop over time.
Genetic disorders can be:
There are many types. They include:
Chromosomal disorders
Multifactorial disorders
Monogenic disorders
Genetic disorders may also cause rare diseases. This group of conditions affects fewer than 200,000 people in the U.S. According to experts, there may be as many as 7,000 of these diseases.
Rare genetic disorders include:
To understand genetic disorder causes, its helpful to learn more about how your genes and DNA work. Most of the DNA in your genes instructs the body to make proteins. These proteins start complex cell interactions that help you stay healthy.
When a mutation occurs, it affects the genes protein-making instructions. There could be missing proteins. Or the ones you have do not function properly. Environmental factors (also called mutagens) that could lead to a genetic mutation include:
Symptoms vary depending on the type of disorder, organs affected and how severe it is. You may experience:
If you have a family history of a genetic disorder, you may wish to consider genetic counseling to see if genetic testing is appropriate for you. Lab tests can typically show whether you have gene mutations responsible for that condition. In many cases, carrying the mutation does not always mean youll end up with it. Genetic counselors can explain your risk and if there are steps you can take to protect your health.
If theres a family history, DNA testing for genetic disorders can be an important part of starting a family. Options include:
Most genetic disorders do not have a cure. Some have treatments that may slow disease progression or lessen their impact on your life. The type of treatment thats right for you depends on the type and severity of the disease. With others, we may not have treatment but we can provide medical surveillance to try to catch complications early.
You may need:
There is often little you can do to prevent a genetic disorder. But genetic counseling and testing can help you learn more about your risk. It can also let you know the likelihood of passing some disorders on to your children.
Some conditions, including certain rare and congenital diseases, have a grim prognosis. Children born with anencephaly typically survive only a few days. Other conditions, like an isolated cleft lip, do not affect lifespan. But you may need regular, specialized care to stay comfortable.
When you are living with a genetic disorder, you may have frequent medical needs. Its important to see a healthcare provider specializing in the condition. They are more likely to know which treatments are best for your needs.
You may also benefit from the support of others. Genetic disorders often have local or national support groups. These organizations can help you access resources that make life a little easier. They may also host events where you can meet other families going through similar challenges.
A note from Cleveland Clinic
Genetic disorders occur when a mutation affects your genes or chromosomes. Some disorders cause symptoms at birth, while others develop over time. Genetic testing can help you learn more about the likelihood of experiencing a genetic disorder. If you or a loved one have a genetic disorder, its important to seek care from an experienced specialist. You may be able to get additional information and help from support groups.
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How would human DNA do in deep space? Experiments from Artemis I being studied at University of Colorado – CBS News
Posted: at 5:18 pm
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Human – Simple English Wikipedia, the free encyclopedia
Posted: January 30, 2023 at 2:25 am
A human is a member of the species Homo sapiens, which means 'wise man' in Latin.[3] Carolus Linnaeus put humans in the mammalian order of primates.[1] Humans are a species of hominid, and chimpanzees, bonobos, gorillas and orangutans are their closest living relatives.
Humans are mammals. They are also social animals. They usually live in groups. They help and protect each other. They care for their children. Humans are bipedal, which means they walk on two legs.
Humans have a complex brain, which is much larger than that of the other living apes. They use language, make ideas, and feel emotions. This brain, and the fact that arms are not needed for walking, lets humans use tools. Humans use tools far more than any other species.
Humans first came from Africa. There are humans living on every continent.[4][5] As of 2022, there were over 7900 million people living on Earth.[6] Overpopulation is a problem.
Humans have a long period of development after birth. Their life depends less on instinct than other animals, and more on learning. Humans are also born with their brains not so well developed as those of other mammals. This makes for an unusually long childhood, and so makes family life important. If their brains were better developed at birth, their head would be larger, and this would make birth more difficult. In birth, the baby's head has to get through the 'birth canal', the passageway through the mother's pelvis.
Many animals use signs and sounds to communicate with each other. But humans have language. It lets them express ideas by using words. Humans are capable of making abstract ideas and communicating them to others. Human language can express things which are not present, or talk about events that are not happening at that time.[7] The things might be elsewhere, and the events may also have occurred at another place or time.[8]
No known animals have a system of communication that is as elaborate as human language. By using words to communicate with each other, humans make complex communities with laws, traditions and customs. Humans like to understand the world around them. They try to explain things through myth, science and philosophy. Wanting to understand things has helped humans make important discoveries.
Humans are the only species living today known to build fires, to cook their food and wear clothes. Humans use more technology than any other animal on Earth ever has. Humans like things that are beautiful and like to make art, literature and music. Humans use education and teaching to pass on skills, ideas and customs to the next generations.
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Humans are part of the animal kingdom. They are mammals, which means that they give birth to their young, and females feed their babies with breast milk. Humans belong to the order of primates. Apes like gorillas, orangutans, chimps, and gibbons are also primates.
The closest living relatives of humans are the two chimpanzee species: the common chimpanzee and the bonobo. Scientists have examined the genes of humans and chimpanzees, and compared their DNA. The studies showed that 95% to 99% of the DNA of humans and chimpanzees is the same.[9][10][11][12][13]
Biologists explain the similarity between humans and other hominoids by their descent from a common ancestor. In 2001, a hominid skull was discovered in Chad. The skull is about 7 million years old, and has been classified as Sahelanthropus tchadensis. This skull may show that the date at which humans started to evolve (develop differently) from other primates is 2 million years earlier than scientists had previously thought.[14]
Humans are part of a subfamily called the Homininae (or hominins), inside the hominids or great apes.
Long ago, there used to be other types of hominins on Earth. They were like modern humans, but not the same. Homo sapiens are the only type of hominins who are alive today.[15] The earliest known fossils of genus Homo have been called Homo habilis (handy man). The first fossils of Homo habilis were found in Tanzania. Homo hablilis is thought to have lived about 2.2 to 1.7 million years ago.[16] Another human species thought to be an ancestor of the modern human is Homo erectus.[17] There are other extinct species of Homo known today. Many of them were likely our 'cousins', as they developed differently than our ancestors.[18] Different species of plants and animals moved from Africa to the Middle East, and then elsewhere. Early humans may have moved from Africa to other parts of the world in the same way.
The first truly modern humans seem to have appeared between 300,000,[19] and 200,000 years ago in East Africa.[20][21][22] In paleontology, 200,000 years is a "short" time. So, scientists speak of a "recent single origin" of humans. Some of these early humans later moved out from Africa. By about 90,000 years ago they had moved into Eurasia. This was the area where Neanderthals, Homo neanderthalensis, had been living for a long time (at least 350,000 years).
By about 42 to 44,000 years ago Homo sapiens had reached western Europe, including Britain.[23] In Europe and western Asia, Homo sapiens replaced the neanderthals by about 35,000 years ago. The details of this event are not known.
At roughly the same time Homo sapiens arrived in Australia. Their arrival in the Americas was much later, about 15,000 years ago.[24] All these earlier groups of modern man were hunter-gatherers.
Early human history is commonly divided into three ages. The time periods are labeled with the material used for tools.
The "Stone Age" is commonly subdivided into the Paleolithic, Mesolithic, and Neolithic periods.
Up to about 10 thousand years ago most humans were hunter-gatherers. They did not live in one place, but moved around as the seasons changed. The start of planting crops for food, called farming made the Neolithic revolution. Some people chose to live in settlements. This also led to the invention of metal tools and the training of animals. About 6000 years ago the first proper civilizations began in places like Egypt, India, and Syria. The people formed governments and armies for protection. They competed for area to live and resources and sometimes they fought with each other. About 4000 years ago some states took over or conquered other states and made empires. Examples include ancient Greece and the Roman Empire.
Some modern day religions also began at this time such as Judaism and Hinduism. From the Middle Ages and beyond humanity saw an explosion of new technology and inventions. The printing press, the car, the train, and electricity are all examples of this kind of invention. As a result of the developments in technology, modern humans live in a world where everyone is connected, for example by telephone or by internet. People now control and change the environment around them in many different ways.
In early times, humans usually settled near to water and other natural resources. In modern times if people need things they can transport them from somewhere else. So basing a settlement close to resources is no longer as important as it once was. Since 1800, the number of humans, or population, has increased by six billion.[25] Most humans (61%) live in Asia. The rest live in the Americas (14%), Africa (14%), Europe (11%), and Oceania (0.5%).
Most people live in towns and cities. This number is expected to get higher. In 2005 the United Nations said that by the end of that year, over half the world would be living in cities. This is an important change in human settlement patterns: a century earlier in 1900 only 14% of people lived in cities, in 2000 47% of the world's population lived in cities. In developed countries, like the United States, 80% of the population live in cities.[26]
Humans have a large effect on the world. Humans are at the top of the food chain and are generally not eaten by any animals. Humans have been described as super predators because of this.[27] Because of industry and other reasons humans are said to be a big cause of global climate change.[28]
Human body measurements differ. The worldwide average height for an adult human male is about 172cm (5ft 7+12in), and the worldwide average height for adult human females is about 158cm (5ft 2in). The average weight of an adult human is 5464kg (119141lb) for females and 7083kg (154183lb) for males.[29][30] Body weight and body type is influenced by genetics and environment. It varies greatly among individuals.
Human hair grows on the underarms, the genitals, legs, arms, and on the top of the head in adults of both genders. Hair will usually grow on the face of most adult males, and on the chest and back of many adult males. In human children of both genders, long hair grows only on the top of the head. Although it might look like humans have fewer hairs than most primates, they actually do not. The average human has more hair follicles, where hair grows from, than most chimpanzees have.[31] Human hair can be black, brown, red or blond.[32] When humans get older hair can turn grey or white.
Human skin colors vary greatly. They can be a very pale pink all the way to dark brown. There is a reason why people in tropical areas have dark skins. The dark pigment (melanin) in the skin protects them against ultraviolet rays in sunlight. The damage caused by UV rays can and does cause skin cancer in some people. Therefore, in more sunny areas, natural selection favors darker skin color.[33][34] Sun tanning has nothing to do with this issue, because it is just a temporary process which is not inherited. In colder climates the advantage of light-coloured skin is two-fold. It radiates less heat, and it absorbs more sunlight. In weaker sunlight a darker body produces less vitamin D than a lighter body. The selection for lighter skin is driven by these two reasons. Therefore, in less sunny areas, natural selection favours lighter skin colour.[35][36][37]
Humans are not as strong as other primates of the same size. An average female orangutan is at least three times as strong as an average human.[38]
The average human male needs 7 to 8 hours sleep a day. People who sleep less than this are generally not as healthy. A child needs more sleep, 9 to 10 hours on average.
The human life cycle is similar in some ways to most other mammals. However, there are some differences. The young grow inside the female mother for nine months. After this time the baby is pushed out of the woman's vagina, with its brain only half developed.
Unlike most other mammals, human childbirth is somewhat dangerous. Babies' heads are large, and the mothers pelvis bones are not very wide. Since people walk on two legs, their hips are fairly narrow. This means that birth can be difficult. Rarely, mother or baby may die in childbirth.[39] The number of mothers dying in childbirth is less in the 21st century. This is because of better medication and treatment. In many poor countries the number of mothers dying is higher. Sometimes it is up to 10 times as many as richer countries.[40]
In the human female, her fertile period in the oestrous cycle is hidden, and mating can take place at any time. That is quite unusual. In mammals generally the fertile period is very noticeable. Mating only takes place when the female signals her fertility. Think about cats, for example. The human cycle is unusual, and it is thought that there is a reason. Humans band together in tribes which have many people. It helps the tribe if the father of a child is not known for certainty. Men live together and work together in much larger groups than do chimpanzees (our nearest living relatives). They have a collective interest in the tribe. It is thought that the human mating system helps this.[41][42]
The average human baby weighs 34 kg at birth and is 5060 cm tall. Babies are often smaller in poorer countries,[43] and may die early because of this.[44]
Humans have four stages in their lives: childhood, adolescence, adulthood and old age.
Life expectancy is how long you are expected to live. This depends on many things including where you live. The highest life expectancy is for people from Monaco, 89.52 years. The lowest is for people from Chad where life expectancy is only 49.81 years.[45]
Psychology is the study of how the human mind works. The human brain is the main controller of what a person does. Everything from moving and breathing to thinking is done by the brain. The human neocortex is huge compared with other mammals, and gives us our thinking ability, and the ability to speak and understand language.
Neurology is the study of how the brain works, psychology is the study of how and why people think and feel. Many aspects of life are also influenced by the hormone system, including growth and sexual development. The hormonal system (especially the pituitary gland) is partly controlled by the brain.
Human behaviour is hard to understand, so sometimes psychologists study animals because they may be simpler and easier to know. Psychology overlaps with many other sciences including medicine, biology, computer science and linguistics.
Language at its most basic is talking, reading and writing. The study of language is called linguistics. Humans have the most complicated languages on Earth. Although almost all animals communicate, human language is unique. Its use of syntax, and its huge learnt vocabulary are its main features.[8][46] There are over 7,300 languages spoken around the world. The world's most spoken first language is Mandarin Chinese, and the most spoken language is English.[47] This includes speakers of English as a second language.
Art has existed almost as long as humans. People have been doing some types of art for thousands of years as the picture on the right shows. Art represents how someone feels in the form of a painting, a sculpture or a photograph.
Music has also been around for thousands of years. Music can be made with only your voice but most of the time people use instruments. Music can be made using simple instruments only such as simple drums all the way up to electric guitars, keyboards and violins. Music can be loud, fast, quiet, slow or many different styles. Music represents how the people who are playing the music feel.
Literature is anything made or written using language. This includes books, poetry, legends, myths and fairy tales. Literature is important as without it many of the things we use today, such as Wikipedia, would not exist.
Humans often categorize themselves by race or ethnicity. Modern biologists know that human gene sequences are very similar compared to many other animals.[48][49][50] This is because of the "recent single origin" of modern humans.[22] That is one reason why there is only one human race.[51][52]:360
Ethnic groups are often linked by linguistic, cultural, ancestral, and national or regional ties. Race and ethnicity can lead to different social treatment called racism.
Religion is a belief of faith in a higher being, spirit, or any system of ideas that a group of people believe in. To have faith in a belief is to have the belief without proof that it is true. Faith can bring people together because they all believe in the same thing. Some of the things religions talk about are what happens after death, why humans exist, how humans came to exist (creation), and what is good to do and not to do (morality). Some people are very religious. Many people believe in one all-powerful god; some people believe in more than one god; some people are atheists, who do not believe in a god; and some people are agnostics, who are not sure if there is a god.
Technology are the things and methods which humans use to make tasks easier. Science is understanding how the universe and the things in it work. Technology used to be quite simple. It was passed on by people telling others, until writing was invented. This allowed technology to develop much quicker. Now people understand more and more about the world and the universe. The use of the telescope by Galileo, Einstein's theory of relativity, lasers, and computing are all scientific discoveries. Technology is of great importance to science, to medicine, and to everyday life.
A war is a lethal fight between large groups of people, usually countries or states. A war involves the use of lethal weapons as both sides try to kill the other. It is estimated that during the 20th century, between 167 and 188 million humans died because of war.[53] The people who fight for a state in wars are called soldiers. The people who fight in wars, but not for a state, are usually called "fighters".
Modern wars are very different from wars a thousand or even a hundred years ago. Modern war involves sabotage, terrorism, propaganda, and guerrilla warfare. In modern-day wars, civilians (people who are not soldiers) are often targets. An example of this is the nuclear bomb dropped on Hiroshima and Nagasaki at the end of World War II. The bombs killed as many as 140,000 people in Hiroshima and 80,000 in Nagasaki by the end of 1945,[54] about half on the days of the bombings. Since then, thousands more have died from wounds or illness because of exposure to radiation released by the bombs.[55] In both cities, the overwhelming majority of the dead were civilians. In Germany, Austria, and Great Britain, conventional bombs were used. About 60,595 British,[56] and 550,000 German,[57] civilians were killed by planes bombing cities.
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Ron Paul hospitalized after he appears to suffer stroke – New York Post
Posted: at 2:13 am
Ron Paul, a former Texas congressman, presidential candidate and the father of Sen. Rand Paul, suffered an apparent stroke-like illness in the middle of a livestream Friday afternoon.
Paul, 85, who was livestreaming his weekday Liberty Report broadcast on YouTube, has been hospitalized for precautionary reasons, Fox News reported.
Message from Ron Paul: I am doing fine. Thank you for your concern, he tweeted just before 3 p.m. alongside a photo of him in a hospital bed, smiling and giving a thumbs up.
A clip of the disturbing medical episode was first tweeted out by the outlet Intelwave.
The live episode may have been a blessing in disguise, the outlet added in a subsequent tweet.
Echoing the sentiment of one of my associates, Im glad it happened live where someone noticed immediately and could get him medical help rather than it happening and him only being found hours later, the tweet said.
Paul ran for president three times, first as a Libertarian in 1988. He then threw his hat in the ring as a Republican in the 2008 and 2012 presidential primaries.
Paul was in the middle of talking about free market economists when he begins to slur his words, according to saved clips of the livestream.
We have to get rid of that and its a burd a burd, he struggles to say before his speech becomes unintelligible.
The YouTube stream was quickly taken down afterward.
Reps for Rand Paul (R-Ky.) and Ron Paul were not immediately available for comment.
The Pittsburgh-born, former pol and physician is a longtime Libertarian and advocate for a free market and small government.
He retired from his five-decade congressional career in 2013 long enough to become the first member of Congress ever to serve at the same time as their child, when Rand Paul was elected to the Senate from Kentucky in 2010.
But he has remained a political firebrand, whether he was insisting that the 9/11 attacks were motivated by U.S. involvement in the Middle East or arguing against COVID-19 quarantines as a restriction of civil liberties.
As recently as April, in a broadcast of his Liberty Report, he called on President Trump to fire Dr. Anthony Fauci, calling the top White House infectious disease expert a fraud for predicting inaccurately, it turned out that initial predictions of as many as 240,000 U.S. coronavirus deaths were too high, and that fatalities might top out at only 60,000.
U.S. deaths hit 200,000 this week.
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Ron Paul Issues an Urgent Warning to Retirement Savers
Posted: at 2:13 am
The following article by Ron Paul is sponsored content by Birch Gold.
If you are nearing your retirement age, all of the hard-earned money you have put away for your future could now be in danger.
Why? Because the worst financial disaster in history is unfolding before our eyes. Call it the everything bubble. Call it the death of the dollar. Call it whatever you want. Most Americans are struggling to make ends meet because of whats happening.
And the elites know things are only going to get worse. For example, the UN secretary-general Antonio Guterres recently said, We are looking into the eye of a Category 5 hurricane. Our world is plagued by a perfect storm on a number of fronts.
Meanwhile, the government thinks the solution is more taxes and more money printing. And dont forget, the far-left Democrat in the White House has targeted retirees multiple times with increased taxes.
Clearly this situation cannot continue! But heres the crucial question: do you really believe Biden wont be able to indirectly get your retirement savings? By continuing to print dollars and eventually driving America into hyperinflation?
If this happens, it would be disastrous for everyone with a stock and dollar-based retirement account.
But the good news is you are not powerless.There is one strategy that can protect your retirement savings from stock crashes, inflation, and Biden.
Its a powerful gold-based retirement strategy that tens of thousands of Americans have used this year. Best of all, there are NO penalties or TAXES when you transfer money into the account. And its all explained in this FREE Info Kit on Gold.
This no-cost guide, which comes from my friends at Birch Gold Group, reveals why Gold IRAs are exploding in popularity right now. And this information is FREE, with no strings or obligations attached. So click here to request your FREE Info Kit on Gold before Biden decides your savings are better spent funding his left-wing agenda.
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The Ron Paul Institute for Peace and Prosperity : Zelenskyy Regime to …
Posted: at 2:13 am
The Zelenskyy regime is desperate. It is reportedlylosing more than 300 soldiers a dayin eastern Ukraine. The latest effort by the doomed regime to throw men and foreign war materiel at a slow and overpowering Russian advance in Donbas will completely fall apart.
The regime is now busy abducting potential bullet stoppers in the Zakarpattia Oblast (Ruthenia), situated in the Carpathian Mountains of southwestern Ukraine, between Slovakia, Hungary, and Romania.
Due to heavy losses, which exceed all previous ones, radical methods are used to replenish the numbers [of troops]. According to local sources, the Ukrainian authorities plan to call up 10,000 people from Transcarpathia by spring, Hungarian journalists toldEuroWeekly.
The Zelenskyy regime has apparently taken a page from the British Royal Navy during the Age of Sail. The British employed press gangs to crew ships during war and peacetime. Refusal to be impressed resulted in a one-way trip to the gallows.
Almost every settlement in Transcarpathia has been for several days now undergoing forced conscription into the army. In the area of the city of Berehove, in Nagysholes, on Sunday the market was surrounded. 70 people were taken away from there, the post continues.
The forced conscription of ethnic Hungarians in Transcarpathia has a political aspect. Viktor Orbn, the PM of Hungary, is a critic of the war in Ukraine.
There is a sort of purposeful policy, which besides narrowing the rights of all minorities, tries to portray the Hungarian minority as the enemy in Ukrainian public opinion,Laszlo Brenzovics, the only ethnic Hungarian in the Ukrainian parliament, told the Associated Press in 2018.
The ultranationalists of Ukraine believe all ethnic minoritiesRomanians, Belorussians, Crimean Tatars, Bulgarians, Hungarians, Poles, Jews, and Armeniansare untermenschen that must be ethnically cleansed.
The current situation is clearly among the worst ones,Trnok Balzswrote in 2021, prior to Russias SMO.
The USG, the UK, and the Europeans are not worried about nazi-ultranats persecuting and ethnically cleansing minorities. The USG is obsessively concerned with making sure its crumbling empire and its devalued fiat dollar remains king in a unipolar world. Everything else, including the welfare of the American people, comes in a distant second.
If resisting Russia requires the crime of kidnapping Hungarians by nazi-ultranats in Transcarpathia and shipping them to die in a Russian military boiler (a cauldron, or encirclement), that is the price the USG believes innocents must pay for its futile and criminal effort to remain top dog perched on a mountain of rotting corpses.
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Gene vs. genome: Definition, function, and impact
Posted: at 1:36 am
DNA is the genetic material or code that tells cells in the body how to replicate themselves. Within this code are genes, which are specific segments of DNA that influence certain aspects of growth and health. Collectively, scientists refer to all of an organisms genes as a genome.
Almost every cell in an organisms body contains a complete copy of its genome, packaged into chromosomes. Chromosomes are thread-like structures consisting of DNA and protein that sit inside cells.
This article will explain what DNA, genes, and genomes are. It will also look at the differences between a gene and a genome and answer some frequently asked questions.
Genes consist of DNA, which is the genetic material that tells cells how to reproduce. Strands of DNA look like a twisted ladder, which scientists call a double helix.
DNA consists of four chemicals, which are known as bases. They are:
The order of these chemical bases in a persons DNA determines how their cells grow and develop.
A gene is a segment of DNA that contains sequences of many bases, varying in size from a few hundred to 2 million. Each gene affects a specific aspect of health. For example, some genes contain instructions on how to make specific proteins.
Parents pass on their genes to their biological children. As a result, each person has two copies of each human gene one from each parent. In total, the human body has between 20,000 and 25,000 genes.
The word genome refers to all the genetic material in an organism. The human genome consists of around 3 billion DNA base pairs.
Almost every cell in the body contains a complete copy of the organisms genome, tightly packaged inside its chromosomes. Chromosomes are present in the nucleus of every cell.
Most of the human genome is the same in all people. However, about 0.001% of the genetic material will be different from person to person. This figure is even smaller in people who are related to each other.
Below are some of the differences between genes and genomes:
Genes influence health in two main ways:
Some variations in genes directly result in health conditions. These conditions are known as genetic disorders. Genetic disorders can be:
In addition to inheriting genetic disorders from parents, people can also spontaneously get them if the gene mutates during fetal development or later in life. This can result in a person having a genetic variation that their parents do not have themselves.
Learn more about autosomal inheritance.
In other cases, genes are merely risk factors for a condition. This means they can raise or lower the risk of someone getting a disease but do not directly cause it.
For example, some people carry genes that raise the risk of certain cancers, diabetes, or heart disease. Doctors call this a nonmodifiable risk factor because a person cannot change their genes.
However, having genes that raise the risk of a condition does not guarantee that a person will get it. Different genes, and different combinations of genes, pose different levels of risk. A persons environment, diet, and lifestyle also influence the risk.
Working on modifiable risk factors, which are things a person can control, can help offset the elevated risk of developing a condition.
Other terms doctors use when talking about genes include:
A gene is a specific segment of DNA that tells cells how to function. A genome is the entirety of the genetic material inside an organism. The human genome consists of between 20,000 and 25,000 genes.
Most of the human genome is the same from person to person, but variations in genes can influence someones health, appearance, and risk of developing certain diseases. There are also some conditions that occur as a direct result of specific genetic variants, such as sickle cell disease.
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Vasan Bala says, censorship is always going to be there, boring to have a black and white discourse | Exclusive – India Today
Posted: January 27, 2023 at 8:46 pm
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Vasan Bala says, censorship is always going to be there, boring to have a black and white discourse | Exclusive - India Today
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