Category Archives: Immortality Medicine

In BriefEric Verdin, a world-leading researcher on aging, recentlyshared what he has learned about the future of growing old. WhileVerdin views immortality as a fairy tale, he said that manypromising methods for extending life are being studied. The Future of Getting Old

The Population Reference Bureau has projectedthat the percentage of the population over the age of 65 will rise from the current 15 percent to a staggering 24 percent by 2060. This means that research into aging has never been more important.

Eric Verdin is at the forefront of this research and has become thePresident and CEO of the Buck Institute for Research on Aging. The institute is the worlds biggest independent research facilitystudying the causes of growing old and how to combat them. Recently, he conducted an interview with Nautilus to discuss how aging is effecting our lives.

Verdin believes that the explosion in age-related research is due to researchers discovery in the 1990s that aging is not necessarily an inevitability. Instead, it is caused by mutations and scientists could make changes to the genome of other species that led to a lifetimes of up to twice as long. Verdin stated in the interview this resulted in a belief that there might be pathways to regulate aging, and if there are pathways that means there are proteins, and that means you can eventually develop drugs.

Despite this, he says, if you hear the word immortality, just run. There is no drug that can give you that. While Verdin believes we can increase the average human lifetime significantly, the fountain of youth is still just a fairy tale. Its just nonsense from my perspective, and I think we should really resist the I-word.

The best way to maximize your lifespan, he said in the interview, is to maintain your body well. Good nutrition and exercise are incredible anti-aging medicine. His general advice is to treat the cause rather than the symptom with a combination of lifestyle and pharmaceutical treatments to fight aging itself rather than dealing with Alzheimers, Parkinsons, or macular degeneration when they occur.

The human attraction to immortality has been present in our cultural landscape since the beginning of time the human mind seems to be unable to resist its lures. There are countless myths and stories based on it: the fountain of youth, the Wandering Jew, the philosophers stone, and the Bibles Enochare a few examples.

Recently, this mystical desire has birthed amyriad of promising methods forreversing the aging process which are currently underinvestigation: from transfusing young peoples blood into older people to give them more osteopontin, to digging into the role telemores play on the aging process, to developing anti-aging, bacteria-based pills.

However, when our increasing life expectancy is combined with the decrease in fertility that many nations are facing, the results arean aging population.In an interview with CNN, Elon Musk pointed out why this is undesirable, saying it causesa very high dependency ratio, where the number of people who are retired is very high relative to the number of people who are net producers an economically detrimental state of affairs.

Due to technological and therapeutic advancements, aging is looking less like an ugly inevitability of our condition and more likea new and exciting epoch in our lives. However,we must ensure that longer lives for people do not come at the expense of the environment, economy, orwellbeing of others.

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We Will Extend Our Lives but Not Attain Immortality, Says Anti-Aging Researcher - Futurism

Abi Jackson gives seven reasons to fall in love with aloe vera this summer

Naturally cooling and soothing, its often hailed for its anti-inflammatory and anti-oxidant qualities. It can help to speed up new cell growth and repair damaged tissues, says nutritionist Cassandra Barns. Thats why its an excellent soother for irritated and burnt skin.

Ultra-refreshing and naturally sweet, aloe vera is making its mark in the healthy drinks market, whether youre glugging an aloe-based drink, or topping up homemade smoothies and juices. Aloe vera is what we call a functional food. In other words, it has health benefits that can enhance our wellbeing, says Simplee Aloe nutritionist Libby Limon, who lists helping to balance energy levels and supporting our immune systems among its properties.

Thought superfoods were a new concept? Throughout history, people have turned to nature in a bid to bolster their health. The Ancient Egyptians dubbed aloe vera the plant of immortality. Its probably not going to make you live forever, but it is packed with vitamins. Aloe vera, often called a miracle plant, has been used in herbal medicine for over 2,000 years, adds Cassandra.

Cravings, energy slumps, mood swings, tiredness... our body has lots of ways of letting us know when were consuming too much sugar. Sometimes, poor blood-sugar balance can contribute to weight gain too, often due to a diet high in carbohydrates with a lack of fibre, healthy fats and protein, notes Libby.

Aloe vera has healthy polysaccharides, which have been shown to aid blood sugar balancing, and therefore can be a great tool to help weight management alongside reducing refined carbohydrates and sugars in the diet.

Aloe vera helps to improve the bodys digestion, beating the all too common bloat which is linked to an imbalance in the digestive tract, says Libby. Aloe vera has been long known for its digestive benefits, which include anti-inflammatory properties and helping to support friendly bacteria.

Aloe vera has a special, hidden quality which allows the body to absorb vitamin C and E from other foods. The body uses vitamin C to make collagen which helps keep skin healthy and elastic, says Libby. And both vitamin C and E are antioxidants, which protect skin against damage and ageing. Beautiful glowing skin is also linked to your digestion, hormone balance and detoxification. The aloe vera inner gel also has components which help with all three of these.

On the lookout for more natural beauty products? It doesnt get much more natural than this: scoop out the gooey insides of the plant, whizz through a blender and then apply to your hair for luscious, conditioned locks, or use as a soothing, replenishing face mask.

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'Miracle plant' aloe vera is versatile and powerful | Irish Examiner - Irish Examiner

on July 11, 2017 at 3:36 pm

(From left) Trevor Torigoe, University of Hawaii John A. Burns School of Medicine Ph.D. student; David Watumull, Cardax, Inc. president and CEO; and Richard Allsopp, Ph.D., JABSOM Institute for Biogenesis Research associate professor and researcher

Humans have long sought to extend their lifespans by staving off physical decline. Gilgamesh went on a quest to find immortality, as did Juan Ponce de Leon, whose search for the fountain of youth ended with his discovery of Florida. Others, like Cleopatra, known for her milk-and-honey baths, were said to have tried reversing the effects of aging (or at least prevent them for as long as possible).

But what has been a futile search for the holy grail of medicine might actually not be so far-fetched any longer.

In fact, the work being done right here at home might very well turn science fiction into reality one day soon.

University of Hawaii John A. Burns School of Medicine (JABSOM) formed a partnership with Hawaii-based life sciences company Cardax Inc. and brought to light a remarkable discovery in terms of how people age.

University of Hawaii at Manoa John A. Burns School of Medicine students Madison Williams (front), Pomaikai Canaday (right) and Ross Villiger (back) dissect ureters from mouse embryos.

The March announcement of their findings all accumulated, analyzed and tested in Hawaii has shaken the medical field.

What the news confirmed was the ability of Cardaxs astaxanthin compound CDX-085 to significantly stimulate FOXO3, a gene all humans have and one that has a proven role in longevity.

Its one thing to know that a gene does something, says David Watumull, president and CEO of Cardax. But its another to be able to do something about it. In the scientific world, thats very unusual.

Researchers have long understood FOXO3 and its involvement with aging, and Cardaxs work with CDX-085 has been known for more than a decade to be important in reducing inflammation but its the relationship between the two that is the innovative breakthrough.

Inflammation, adds Watumull, is the underlying driver for most chronic illnesses related to aging, such as cardiovascular disease, gastrointestinal disease, liver disease and kidney disease. Even those with dementia, depression, Alzheimers, PTSD and bipolar disorder are impacted by inflammation.

This kind of commitment, I mean, this is an amazing service theyve done. Not just for Hawaii and for this country, but for the world.

DR. BRADLEY WILLCOX JABSOM Department of Geriatric Medicine professor and director of research These are all really important tissues with regard to aging, says Dr. Bradley Willcox, JABSOM Department of Geriatric Medicine professor and director of research. If your liver doesnt work, youre done. If your muscles dont work, youre crippled. If your brain doesnt work, you might as well be done. If your heart doesnt work, youre certainly done.

It is such a vital aspect of overall health that many have started using the term inflamm-aging.

Studies that test aging utilize life forms such as yeast, flies, worms and mice model organisms made up of genes that are conserved across evolution.

And the JABSOM-Cardax study moved science up the phylogenetic ladder. What once was only studied in worms has now been proven in mammals, specifically mice, which are an important physiological model, as they share a big chunk of their genome with humans.

The preliminary research conducted by JABSOM-Cardax the first of its kind to test astaxanthins ability to activate FOXO3 in mammals fed mice normal fare and others food containing a low or high dose of CDX-085.

The study found that CDX-085 stimulates FOXO3 to express properties that positively affect aging.

We found a nearly 90-percent increase in the activation of the FOXO3 longevity gene in the mice fed the higher dose of the astaxanthin compound CDX-085, stated Richard Allsopp, Ph.D., JABSOM Institute for Biogenesis Research associate professor, in a release.

FOXO3 comes in two basic forms, with a single DNA letter distinction those with TT (most of the population) and those that have a G somewhere in the mix (GT or GG).

About one-third of the population has GT, which doubles the odds of living to 100, says Willcox. Those lucky enough to have GG? They have triple the odds of living to be 100. For those fortunate few, they have won the genetic lottery, so to speak.

You really just need to be a carrier to have just one of those G letters to have the longevity effect, Willcox explains.

But, adds Watumull, a person doesnt need to have a good FOXO3 version for Cardaxs CDX-085 compound to work. It simply turns FOXO3 on, making it as if a TT person has the GT or GG version.

Youre not at a loss, Willcox continues. Because now we have a way to activate it.

Cardax and JABSOM announced the results of their study earlier this year, but representatives are quick to note that nothing would have come to fruition if it werent for the Kuakini Honolulu Heart Program, which is one of the largest ongoing studies in the world on aging men.

JABSOM researchers chose 30 genes that had been shown in model organisms to be important for longevity and were able to compare them to genetic data from

Kuakini Honolulu Heart Program. The gene that stood out? FOXO3.

This data set doesnt exist anywhere else in the world, says Watumull of Kuakini Honolulu Heart Program. And thats what has resulted from that is this breakthrough.

Initial study volunteers about 120 currently still living have continued to give blood samples and medical information for more than 50 years (the program started in 1965), making the data pool even richer, and their children also have volunteered for the offspring study.

This kind of commitment, I mean, this is an amazing service theyve done, says Willcox. Not just for Hawaii and for this country, but for the world.

And to actually take work thats being done in Hawaii, following from the 1960s with Japanese-American men, coming up with a gene that affects longevity, defining it, knowing what it is, and then having another Hawaii company actually be able to do something all in the state thats really unusual, Watumull adds. Thats really unusual to be able to do any of that, any one of those steps, but to put them all together and all in Hawaii, thats a breakthrough.

Others already are seeing the benefits of the JABSOM-Cardax findings.

Just last month, CDX-085 was chosen for the National Institutes on Agings prestigious Interventions Testing Program, which, says Willcox is a game changer. He, along with Allsopp, submitted a proposal in the hopes that the compound would be one of the very few to be chosen.

And its selection, adds Watumull, is totally validating.

Were the ones that discovered this, we put together this concept, we can export it, bring people here to experience the benefits, he muses.

Linking CDX-085 and FOXO3 has provided, in a way, the catalyst for numerous medical possibilities. According to JABSOM, scientists also are planning human clinical trials to see, for example, if CDX-085 could improve cognitive function in people with early dementia.

It is their hope that one day Hawaii can be the foremost expert on aging joining the ranks of medically renowned, field-specific institutions such as MD Anderson Cancer Center, Cleveland Clinic and Mayo Clinic. And, says Watumull, its not improbable in the slightest. At least, not anymore anyway.

We have the tools today to offer something meaningful, real and unparalleled at this point in time, he says. Hawaii can serve as the kind of anti-aging center of excellence for the world.

For more information, visit cardaxpharma.com or jabsom.hawaii.edu.

PHOTOS BY LAWRENCE TABUDLO

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THe Secret To A Longer Life - Midweek

Icon of Jesus at the Mystical Supper. Photograph by Henry Karlson

We are born again in baptism, then we find ourselves sanctified in the Spirit through the anointing of chrism. But as we are limited beings in the world, and we find ourselves consistently needing to eat and drink in order to extend ourselves and add to our potential energy lest we die, so we need spiritual nourishment to extend our spiritual potential and grow in the spirit lest we find a limit to our spiritual growth and then find ourselves facing a living-death, where our spiritual potential is, as it were, stretched to the limit in eternity.

In the whole of our being, body and soul, we hunger and thirst. We seek after food so we do not suffer loss. But the greatest food is that which can help our whole being, body and soul, at once, nourishing both that neither finds a limit to its potentiality before being stretched thin.

In our core, we thirst, and we receive the stream of living water, the Holy Spirit; likewise, we hunger, and receive the bread of life, by which we are able to partake of eternal life. Jesus said that he is himself that bread of life; he is the one who has come down from heaven in order for us to partake of him. In this manner, we can abide in him as he abides in us, and so we share in his infinite potential and life in a way which whatever we need, we can have from him and so never suffer loss:

I am the living bread which came down from heaven; if any one eats of this bread, he will live for ever; and the bread which I shall give for the life of the world is my flesh.

The Jews then disputed among themselves, saying, How can this man give us his flesh to eat? So Jesus said to them, Truly, truly, I say to you, unless you eat the flesh of the Son of man and drink his blood, you have no life in you; he who eats my flesh and drinks my blood has eternal life, and I will raise him up at the last day. For my flesh is food indeed, and my blood is drink indeed. He who eats my flesh and drinks my blood abides in me, and I in him. As the living Father sent me, and I live because of the Father, so he who eats me will live because of me. This is the bread which came down from heaven, not such as the fathers ate and died; he who eats this bread will live for ever (Jn. 6:51 8 RSV).

Even in the way he came to us in his birth, he revealed to us that he came to give us of himself as the bread of life. As St. Anthony of Padua explained, the incarnation works in and through fitting symbols which reinforce each other, and here, we find Jesus being born in Bethlehem hints at his being the bread of life:

He is also called a Bethlehemite. Bethlehem means house of bread. He feeds us in the Church with the bready of his Body:

the bread will give is my flesh, for the life of the world. [Jn 6:52][1]

Jesus was born in the house of bread, to be the true Bethlehemite, indeed, to fulfill the meaning behind Bethlehem itself. He came to the world, not in some ordinary home, not even in an ordinary room at some inn, but in a manger, fulfilling what it means to be a Bethlehemite, for the manger is the place in which food is stored for animals. We are, to be sure, animals ourselves, and by coming to Christ, we come to the manger to feed. Jesus remains every in the manger as he is our food, the bread of life which has come down to the house of bread, so that we might live forever. We are nourished by the flesh and blood of Christ. Even as an infant, he was put on display in a trough. He came down from heaven and immediately showed he was to give of himself to us as our feed.

In receiving him, we are received by him; by eating the gift of the bread of life, we discover what eating itself is all about. Normally what we eat becomes a part of us as we absorb what we can receive and expel that which we cannot. By receiving the eucharist, we have Jesus presence in us, and we find ourselves receiving the medicine of immortality, the food which transforms us into the body of Christ. But instead of absorbing Christ in us, we find ourselves being taken in by Christ and become one with him in and through our reception of his holy gifts. We truly find ourselves abiding in him because we first opened ourselves up to let him abide in us. By accepting him, by eating his gift of himself found in the eucharist, we find he has entered us and transforms us. Thus, he is not consumed like simple food, but nonetheless, he still allows us to become what we eat, himself, as Hugh of St. Victor explained:

Finally we eat the flesh of the lamb when by taking His true body in the sacrament we are incorporated with Christ through faith and love. Elsewhere what is eaten is incorporated. Now when the body of Christ is eaten, not what is eaten but he who eats is incorporated with Him whom he eats. On this account Christ wished to be eaten by us, that He might incorporate us with Him.[2]

Christ takes what humans need in order to survive, food, and turns himself into it in order to fulfill the human condition and lift it up so that all that is truly and properly human finds itself received by him as a means of receiving him. Our body is real and represents a truth about ourselves which must not be denied. We are not Gnostics rejecting the functions of our body. All that Christ assume is itself able to be transformed by him and used by him for our gain.

As that which we eat is from what has been killed and so dead, we receive the lamb of God slain from the foundation of the world, from the one who died for our sake, so we can eat him and receive everlasting life. Ordinary food helps us in our temporal existence; our spiritual food of the bread of life, of the flesh and blood of Christ offered for us, gives us what we need in order to ne nourished in eternity.

He made it clear through repetition that he truly wants to believe he is the bread which has come down from heaven, that he truly came to give us his flesh and blood to eat and drink. He did not want us to think it was mere metaphor: he had many chances to indicate it was, but instead, through his repetition and how he declared himself to be the bread of life, he became more emphatic about it. We cannot neglect the meaning which he gave; we can dismiss it as absurd, and so dismiss him, but he did not offer those who believed in him and followed him any other choice than to accept this hard saying.

What Moses gave was food for the journey of life; it was manna from heaven which was good and helpful; but what Moses gave was only a foreshadow of what God sent to us in Jesus, so that we have food, not just for a particular day and time, but for eternity the difference between the two is night and day, with Moses giving a shadow of the things to come:

Jesus then said to them, Truly, truly, I say to you, it was not Moses who gave you the bread from heaven; my Father gives you the true bread from heaven. For the bread of God is that which comes down from heaven, and gives life to the world (Jn. 6:32-3 RSV).

Clearly, what Jesus said shocked his listeners; after he made sure they knew how serious he was by the emphasis he put in his words, many of them left (cf. Jn. 6:66). They, like so many others throughout the centuries, could not understand how and why we would be called to eat Jesus himself. It sounded like cannibalism. At least for those listening to his speech here, since he had yet to explain how he would offer himself as good, it is far easier to forgive those who departed at that point than those who later rejected his words after he revealed how he was to give himself in holy communion. What were the disciples to believe? How could they understand his enigmatic and cryptic words? Obviously, those who had already come to know and love Jesus knew he could be enigmatic, that his words could be filled with paradoxes which they could not comprehend. Thus, they continued to follow him even when others rejected him due to such confusion. They had already seen the glory of God manifested in him, attracting them to him, bringing out their love and acceptance of him, so that they could come to him in a faith which was open to the truth and the awareness such truth gave to them. They could know the truth even if they could not comprehend it; they could accept the truth and contemplate it with human reason, to see a kind of logic associated with it even if they saw the limits of human logic as it came face to face with the face of truth in Jesus himself. They continued to follow him even when he challenged them, but others, as soon as they found themselves challenged, left grumbling (cf. Jn. 6:66).

[1] St. Anthony of Padua, Sermons for Sundays and Festivals. Volume I. trans. Paul Spilsbury (Padova: Edizioni Messaggero Padova, 2007), 341.

[2] Hugh of Saint Victor, On the Sacraments. Trans. Roy J. Deferrari (Cambridge: Medieval Academy of America, 1951), 307.

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On The Eucharist: Part One - Patheos (blog)

In BriefResearchers have identified a single gene deletion in E. colibacteria that influence longevity in C. elegans worms. This pointsto the role of gut bacteria in life extension and points to thepossibility of a life-extending probiotic in the future.

Researchers at the Baylor College of Medicine have found the key to longevity in Caenorhabditis elegans (C. elegans) worms and maybe, someday, humans. The team noticed that genetically identical worms would occasionally live for much longer, and looked to their gut bacteria to find the answer. They discovered that a strain of E. coli with a single gene deletion might be the reason that its hosts lives were being significantly extended.

This study is one among a number of projects that focus on the influence of the microbiome the community of microbes which share the body of the host organism on longevity. Ultimately, the goal of this kind of research is to develop probiotics that could extend human life. Ive always studied the molecular genetics of aging, Meng Wang, one of the researchers who conducted the study, told The Atlantic. But before, we always looked at the host. This is my first attempt to understand the bacterias side.

Even in cases like this, where it seems fairly obvious that the microbiome is influencing longevity, parsing out the details of how and why this happens among a tremendous variety of chemicals and microbe species is extremely complex. The team, in this case, was successful because they simplified the question and focused on a single relationship.

Genetically engineering bacteria to support and improve human health and even to slow aging and turning it into a usable, life-extending probiotic wont be easy. It is extremely difficult to make bacteria colonize the gut in a stable manner, which is a primary challenge in this field. The team, in this case, is looking to the microbiome, because the organisms used would be relatively safe to use because they would originate in the gut.

Clearly, researchers dont know yet whether these discoveries will be able to be applied to people, though it seems promising. Despite the obvious differences between the tiny C. elegans worm and us, its biology is surprisingly similar; many treatments that work well in mice and primates also work in the worm. The team will begin experiments along these same lines with mice soon.

Other interesting and recent research hoping to stop or slow the march of time includes work with induced pluripotent stem (iPS) cells, antioxidants that target the mitochondria, and even somewhat strangework with cord blood. It seems very likely that we wont have a single solution offering immortality anytime soon, but instead a range of treatment options that help to incrementally hold back time. And, with an improving quality of life, this kind of life extension sounds promising.

Continue reading here:
This Study Could Help Extend the Human Lifespan - Futurism

We arent worthy of immortality. Indeed, weve already passed our sell by date. Photograph: VCG/VCG via Getty Images

Last week, as the Senate was still trying to deny health care to 22 million fellow Americans, a friend asked me whether I would choose to live forever if I could. We were discussing Silicon Valley billionaires and their investments in new bio-technologies that they hope will enable them to do what no human has ever done: cheat death. The technology includes some dubious treatments, like being pumped with the blood of much younger people.

Both of us agreed we do not wish for immortality, though we are both extremely happy with our lives and healthy. Wanting to live forever is fundamentally selfish. Its obvious why immortality appeals to billionaires like Peter Thiel. It obviously wouldnt to the millions in the US who wont have health insurance if the Republicans pull out the vote on their bill.

Peter Thiel, the PayPal founder who is a friend of Trump, is one of the Immortalists. Lucky that he will never run out of money, especially since the Senates version of Repeal and Replace Obamacare is such a generous giveaway to the billionaire class.

The only reason its getting any Republican votes is that, as The New York Times reported a few days ago, The bills largest benefits go to the wealthiest Americans, who have the most comfortable health care arrangements, and its biggest losses fall to poorer Americans who rely on government support.

It should be called The John Galt Bill after the hero of Ayn Rands Atlas Shrugged, the doorstopper of a novel that is akin to the Bible for certain conservative politicians, including House Speaker Paul Ryan, who hands out copies of the book to newly elected Members (The House version of the health care bill is even more Galtian than the Senates). Its the only book Im aware of that Donald Trump claims to have read.

Keep in mind that at her funeral in New York in 1982, Ayn Rands body lay next to the symbol she had adopted as her own - a six-foot dollar sign, according to Susan Chira who covered the service for the Times. A few years ago, The Atlas Society, which keeps the Rand flame alive, urged Senate Majority Leader Mitch McConnell to unleash our inner John Galt. They must be celebrating because even they could not have come up with a more hard-hearted piece of legislation.

If the White House actually fights for the bill, it will be because it repeals the higher taxes on estates and the Medicare surcharge that helped fund President Obamas expansion of health care to cover the poor. Although he has said the House version of the bill is too mean, hes happy to see his billionaire friends evade the governments hand in their pockets. (Hey, wed certainly like to see your taxes so we can figure out how you would make out, Mr President).

In an effort to reduce the meanness of the bill somewhat, McConnell is reported to be considering something wealthy Republicans hate, preserving the Obama laws 3.8% tax on investment income in order to provide more money for combatting opioid addiction and other services to the poor. Its unclear whether that would unlock enough votes to pass a bill.

The Presidents 71st birthday a few weeks ago made him one of the oldest surviving Boomers, those of us born between 1946 and 1964, a generation that is notoriously selfish and also physically fit, (though the presidents recent photos on the golf course raise questions about the latter). In the presidents case, the typical Baby Boom self-centeredness has blossomed into a raging form of megalomania.

In 2020, the president may be running for re-election and I will be one of the many Boomers who have officially become senior citizens. More importantly, it will also be the year that the number of those over 65 will be larger than those under 5. Thats unhealthy for many reasons, not least of which is the pressure it will put on Medicare and Social Security.

The billionaire class does not need to worry, however, because their tax savings from the repeal of Obamacare, if it ever passes, will easily pay for a lifetime of concierge medicine. (Well, maybe not, if Thiels plan to live forever works out).

Since modern American politics is always a revenge cycle, one way to look at the Republican health repeal measures is as payback to Chief Justice John Roberts, who infuriated Republicans in 2012 when he sided with the US Supreme Courts four liberals to uphold the Affordable Care Act. He finessed his decision by defining the individual mandate as a tax, citing congressional power to levy taxes. Now McConnell & Co are using that same power to repeal them and make the billionaires richer.

Health care is not the only area in which supreme selfishness guides the Trump administration. Washington Post columnist David Ignatius had a strong piece on Wednesday showing many examples of other countries adopting Trumps America First mantra and adapting it to themselves.

In the Middle East, Saudi Arabia and the United Arab Emirates bully Qatar into bending to their will, as the Kurds forge on with their independence drive, both selfish moves that dont even consider how they may destabilize the rest of the region. Pulling out of multi-lateral treaties, like the Paris and Trans-Pacific accords, because Trump says they dont put US interests first is also supremely selfish, as Ignatius rightly points out.

Its no wonder theres something called Boomer Death Watch. We arent worthy of immortality. Indeed, weve already passed our sell by date.

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Billionaires dream of immortality. The rest of us worry about healthcare - The Guardian

The quest for immortality is an oft repeated story throughout history, but its only in the past century that the movement has pivoted from the annals of religious escapades and spiritual endeavors, to the realms of scientific and technological research. But is it possible? A study published in Nature last October suggested no humans beings, in the speciess current state, seem have maxed out at 115 years. Five separate research teams, however, are strongly contesting that notion.

Those groups new studies, published as a series in the new issue of Nature, together rebut the notion that there is even a finite age to the human body.

The 2016 study, led by molecular geneticist Jan Vijg from Albert Einstein College of Medicine, essentially analyzed global demographic data from the last century and appeared to illustrate that peak age in humans plateaued at 114.9 years. Vijg and his colleagues argued that this was most likely the natural age limit of human beings, and the probably of living past up to or over age 125 was less than 1 in 10,000.

Jim Vaupel, an expert in ageing at the Max Planck Institute for Demographic Research in Germany and one of the authors of the new papers, told The Guardian, The evidence points towards no looming limit. At present the balance of the evidence suggests that if there is a limit it is above 120, perhaps much above and perhaps there is not a limit at all.

The new papers take on a multi-pronged approach to critique that conclusion, utilizing data in several different ways to portray more optimistic interpretations of human mortality limits. One paper, for example, presents a scenario where the data suggests the mortality is still steadily rising, and that by the year 2,300, the oldest person could be 150 years old.

A big complaint about the 2016 study is that it split the data into two time periods according to the year 1995, where it was the determined the plateau of human age began. The the trends calculated after 1995 showed a flat gradient that confirmed that hypothesis, which Siegfried Hekimi from McGill University in Montreal, one of the authors of the new papers, says is the wrong kind of statistical approach.

Vijg, for his part, has suggested in comments to The Guardian and The Scientist that maximum lifespan is a hard topic for many people to discuss. He defends his analytical methods as part of the variable way statistics can be conducted these days.

Perhaps Vijgs best argument is one he hasnt even made yet that human lifespan perhaps needs to be finite*, and that evolution has ensured this limit. The longer individuals in a given species live, the more resources they take up to keep living resources that cannot go to newborns and others who are of ripe reproductive age.

There many other quibbles with the 2016 paper the new studies dig into, but perhaps one of the biggest problems is simply the fact that longevity studies are based on a very small sample size. There arent a whole lot of people alive (or who have lived very lengthy lives) who can help demonstrate what a maximum age limit might be. Age studies are essentially limited by the fact that reaching a maximum age is extremely difficult at least naturally.

Of course, there are plenty of rich people looking to change that. Hey there, Silicon Valley!

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There's No Upper Limit to Human Lifespan, Argue Scientists - Inverse

Dont mess with our collective dreams of immortality. A flurry of new research vigorously opposes a study from last year that dared to suggest there might be a ceiling to the human lifespan.

In one new paper, Dutch scientists predict, by 2070, our lifespan may increase to 125 years while, beyond that, the sky may be the limit. Their analysis was published Wednesday in the journal Nature.

The debate over his original paper, published last October in Nature and widely reported by CNN and other media outlets, took Jan Vijg, senior author, by surprise.

For a biologist, a natural limit to the lifespan makes a lot of sense, so thats why I never imagined the paper would stir up so much comment, said Vijg, a professor at Albert Einstein College of Medicine in New York.

New analysis

To prove a 125-year lifespan is possible, researchers from the Netherlands Interdisciplinary Demographic Institute team began their study by refuting the relationship between age and immortality posed by Benjamin Gompertz.

This 19th-century mathematician pored over mortality data and noticed young people have a very low chance of dying. Yet, in middle age, the chance of dying increases and then rises again dramatically in old age.

This exponential increase in the rate of human mortality has long been accepted wisdom, yet the Dutch researchers decided to challenge it. Instead of basing their work on data derived from the general population, they used data from a group of people noted for their long lives Japanese women.

Using mathematical models, they claim mortality goes down in old age and projected an astounding new human lifespan 125 years will be achieved by 2070.

Along with this theory, an additional four separate papers poke holes in Vijgs work. A Canadian team of scientists claims Vijgs original paper is based on statistically noisy (or meaningless) data. Meanwhile, a research team from the University of Copenhagen argues any inferences about lifespan potential are premature; a team from the Max Planck Institute claims theres simply no evidence of a looming limit; and a team from the University of Groningen offers four cohesive arguments contesting the conclusions drawn by Vijgs team.

What inspired this heated debate?

Record-breakers

In their paper, Vijg and his graduate students, Xiao Dong and Brandon Milholland, analyzed aging trends in the United States, the United Kingdom, France and Japan.

Vijg explained their analysis was based not on some mathematical model that projected future data but on actual data of real human lives. They examined not one but two different data sets, and what they observed was, despite life expectancy being dramatically higher than it was 100 years ago, the probability of anyone living for more than 125 years was unlikely.

Initially, you see this increase every year, and you see this oldest record holder until the 1990s and then it stops, Vijg said. Think about it, how strange it is.

The number of healthy centenarians increased dramatically every year. That being the case, Vijg theorized the supply is certainly there to create more record-breakers, every year, yet there were none.

Vijg wondered How is that possible? A decades-long plateau following years of new old-age records must mean humans have reached the lifespan limit, he and his colleagues concluded.

It is a rather logical conclusion for biologists, who have long seen individual animal species each have a particular span of time in which they are born, develop into maturity and then die, Vijg explained.

When Jeanne Calment died, I really thought that this was the beginning of something very dramatic, Vijg said.

Calment died in 1997 at age 122, which remains the greatest fully authenticated age to which any human has ever lived, according to Guinness World Records.

Hearing about Calments long life, Vijg rebelled against the accepted wisdom that lifespan must be fixed, it must be like a ceiling.

Yet, testing the theory, Vijg and his co-authors found no fresh old-age record breakers. Sure, the Canadian scientists who created a mathematical model found random plateaus, some seven years long but still their research fails to explain a plateau of decades, Vijg said.

The Canadian scientists may believe their research disproves his but, instead, it is a beautiful confirmation of what we found, he said.

They want us to be wrong, said Vijg, who with his colleagues published a rebuttal to all the criticism. I can see that its very depressing when you find out that we can never get older than 115 years on average.

Vijg, though, is not a depressed man.

He said hes seen the tremendous strides made in all scientific fields as well as technology and hopes someday the aging process might be halted.

We may be able to do that at some point, as I say, by the way, at the end of my paper. But, if we are not able to do that because aging turns out to be still very mysterious or a process that we cannot really intervene with, then we are stuck with a real maximum lifespan that fluctuates around 115, Vijg said. Accept it.

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Living to 125 and beyond: Scientists dispute there's a limit to our lifespans - kfor.com

(CNN) -- Don't mess with our collective dreams of immortality. A flurry of new research vigorously opposes a study from last year that dared to suggest there might be a ceiling to the human lifespan.

In onenew paper, Dutch scientists predict that, by 2070, our lifespan may increase to 125 years while beyond that, the sky may be the limit. Their analysis was published Wednesday in the journal Nature.

The debate over hisoriginal paper, published last October in Nature andwidely reported by CNNand other media outlets, took Jan Vijg, senior author, by surprise.

For a biologist, a natural limit to the lifespan "makes a lot of sense, so that's why I never imagined the paper would stir up so much comment," said Vijg, a professor at Albert Einstein College of Medicine in New York.

To prove a 125-year lifespan is possible, researchers from the Netherlands Interdisciplinary Demographic Institute team began their study by refuting the relationship between age and immortality posed byBenjamin Gompertz.

This 19th-century mathematician pored over mortality data and noticed that young people have a very low chance of dying. Yet, in middle age, the chance of dying increases and then rises again dramatically in old age.

This exponential increase in the rate of human mortality has long been accepted wisdom, yet the Dutch researchers decided to challenge it. Instead of basing their work on data derived from the general population, they used data from a group of people noted for their long lives -- Japanese women.

Using mathematical models, they claim mortality goes down in old age and projected an astounding new human lifespan -- 125 years -- will be achieved by 2070.

Along with this theory, an additional four separate papers poke holes in Vijg's work. ACanadian teamof scientists claims Vijg's original paper is based on statistically "noisy" (or meaningless) data. Meanwhile, a research team from theUniversity of Copenhagenargues that any inferences about lifespan potential are premature; a team from theMax Planck Instituteclaims there's simply no evidence of a "looming limit;" and a team from theUniversity of Groningenoffers four cohesive arguments contesting the conclusions drawn by Vijg's team.

What inspired this heated debate?

In their paper, Vijg and his graduate students, Xiao Dong and Brandon Milholland, analyzed aging trends in the United States, the United Kingdom, France and Japan.

Vijg explained that their analysis was based not on some mathematical model that projected future data, but on "actual data" of real human lives. They examined not one but two different data sets, and what they observed was that, despite life expectancy being dramatically higher than it was 100 years ago, the probability of anyone living for more than 125 years was unlikely.

"Initially, you see this increase every year and you see this oldest record holder until the 1990s, and then it stops," said Vijg. "Think about it, how strange it is."

The number of healthy centenarians increased dramatically every year. That being the case, Vijg theorized "the supply is certainly there" to create more record-breakers, every year, yet there were none.

Vijg wondered, "How is that possible?" A decades-long plateau following years of new old-age records must mean humans have reached the lifespan limit, he and his colleagues concluded.

It is a rather logical conclusion for biologists, who have long seen that individual animal species each have a particular span of time in which they are born, develop into maturity, and then die, Vijg explained.

"WhenJeanne Calmentdied, I really thought that this was the beginning of something very dramatic," said Vijg. Jeanne Calment died in 1997 at age 122, which remains "the greatest fully authenticated age to which any human has ever lived," according toGuinness World Records.

Hearing about Calment's long life, Vijg rebelled against the accepted wisdom that lifespan "must be fixed, it must be like a ceiling."

Yet, testing the theory, Vijg and his co-authors found no fresh old-age record breakers. Sure, the Canadian scientists who created a mathematical model found random plateaus, some seven years long -- but still their research fails to explain a plateau of decades, said Vijg.

The Canadian scientists may believe their research disproves his, but instead, it "is a beautiful confirmation of what we found," he said.

"They want us to be wrong," said Vijg, who with his colleagues published arebuttalto all the criticism. "I can see that it's very depressing when you find out that we can never get older than 115 years on average."

Vijg, though, is not a depressed man.

He says he's seen the tremendous strides made in all scientific fields as well as technology and hopes that someday the aging process might be halted.

"We may be able to do that at some point, as I say, by the way, at the end of my paper," said Vijg. "But if we are not able to do that because aging turns out to be still very mysterious, or a process that we cannot really intervene with, then we are stuck with a real maximum lifespan that fluctuates around 115."

"Accept it," he says.

The-CNN-Wire & 2017 Cable News Network, Inc., a Time Warner Company. All rights reserved.

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Living to 125 and beyond: Scientists dispute there's a limit to - KMOV.com - KMOV.com

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Forget the Blood of Teens. This Pill Promises to Extend Life for a Nickel a Pop. - WIRED