Category Archives: Human Longevity

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The Department of Health and Human Services (HHS) recommends American adults complete 150-300 minutes of moderate physical activity each week or 75-150 minutes per week of vigorous physical activity.

Although a 2018 study found around 80 percent of U.S. adults and adolescents are insufficiently active, those who exceed HHS thresholds are more likely to live longer, according to new research published in the American Heart Associations (AHA) journal Circulation.

The study also found no harmful cardiovascular health effects among individuals completing four times the minimum recommended physical activity levels. However, exceeding this threshold also did not result in any additional reduction in death risks.

America is changing faster than ever! Add Changing America to your Facebook or Twitter feed to stay on top of the news.

In an effort to better understand whether exercise above recommended amounts led to benefits or drawbacks to individuals cardiovascular health, researchers assessed the physical activity and medical records of more than 100,000 people over the span of 30 years.

While those who met the recommended levels of moderate and vigorous activity had a 20-21 percent and 19 percent lower risk of all-cause mortality, respectively, participants who completed two to four times that amount exhibited even greater risk reductions.

Those in the latter group who completed more vigorous activity than recommended had a 21-23 percent lower risk of death, while those who completed more moderate activity saw a 26-31 percent lower risk.

Data were gleaned from the Nurses Health Study and Health Professionals Follow-up Study,from 1988 through 2018. The majority of participants assessed were white females, while average participant age was 66.

Measurements of physical activity were self-reported. Exercise like walking, weightlifting and calisthenics were classified as moderate activity; jogging, running, swimming and biking were considered vigorous activities.

In general, physical activity at or above recommended levels was associated with lower risks of cardiovascular disease-related death and all-cause death.

We have known for a long time that moderate and intense levels of physical exercise can reduce a persons risk of both atherosclerotic cardiovascular disease and mortality, said former AHA president Donna K. Arnett, who was not involved in the study, in a press release.

We have also seen that getting more than 300 minutes of moderate-intensity aerobic physical activity or more than 150 minutes of vigorous-intensity aerobic physical exercise each week may reduce a persons risk of atherosclerotic cardiovascular disease even further, so it makes sense that getting those extra minutes of exercise may also decrease mortality, Arnett added.

Published on Jul. 25, 2022

Original post:
Exercising more than recommended could prolong your life: study - The Hill

EATING 30 different fruits and vegetables a week, taking an early night and having a cold shower could be the key to living longer, preventing illness and losing weight.

Top neuroscientist Dr Julia Jones says simple changes to our daily routine are more beneficial than the gym.

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She told Sun on Sunday Health: Just making simple adjustments to our lifelong routine can add decades of healthy life.

Julia runs an eight-week smart wellness longevity plan to help people boost their life expectancy.

Here she shares her top ten tips.

DELAYING your breakfast a few times a week can give cells the full time they need to do essential repair work, reducing your risk of everything from cancer to Type 2 diabetes.

Leave 16 hours overnight between your last meal.

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Drinks during the fasting window are OK. Just dont fill them with sugar or milk.

Stick with water, tea and coffee. Many scientists, including me, now regularly eat one healthy meal a day.

RESEARCH has shown that people with a higher diversity of gut bacteria have a reduced risk of illness.

But eating the same five fruits and veg each day doesnt boost diversity.

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You should aim to try 30 different types a week to boost gut diversity.

Frozen fruits and veg work as well as fresh, sobuy different frozen products in bulk to keep costs down.

YOU dont need a full gym workout but get out of breath a few times a week. Stop using the lift and take the stairs.

Walk faster. Short bursts will work simply adjust some if your habits.

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Cycle to the shops instead of driving.

ALL our organs age at different speeds. There are biological clocks working at different rates inside us.

Our skin actually ages fastest and this means we need to take extra care of it.

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When the skin suffers, it not only experiences damage in its own cells but also sends damaging signalling molecules through our bloodstream that can reach other parts of the body and kickstart problems elsewhere.

Always wear high SPF sunscreen, even when its cloudy.

OUR gut is home to lots of microbe bacteria and when they are not in balance, our health may hit trouble.

Keep your gut healthy by regularly having food and drinks that contain live bacteria known as probiotics for example, kombucha drinks, kefir, live yogurts and fermented sauerkraut.

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Note also that if a fermented food is not kept in a stores refrigerated section, the product will not contain live bacteria.

LISTS help to declutter our minds and reduce stress. Just writing one produces changes in the brain, reducing levels of the stress hormone cortisol.

And then, once you successfully tick a few things off, the feel-good reward chemical dopamine will be released in the brain.

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You will feel a buzz.

DAMAGE to the brain can start decades before symptoms become apparent, especially if we are overweight.

Brains have been shown to shrink as waistlines grow. Ensure your brain is getting good blood supply and calming signals by walking outdoors in nature every day.

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You also need to challenge the brain throughout life by learning new, complex tasks to build new connections try learning a musical instrument or a newlanguage.

BEING exposed to very hot or very cold conditions is potentially life-threatening for the human body.

But putting ourselves in these environments for short periods activates longevity pathways in our cells for positive health effects.

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Turn your shower to cold for a burst, go swimming outdoors or have a hot sauna.

LOSS of muscle tissue leads to frailty and increased risk of falls and fractures. It also lowers the effectiveness of your immune system.

To beat that decline you need to overload muscles regularly.

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Do slow-motion moves that make your largest muscles reach the point of fatigue try doing push-ups or squats really slowly until you cant do any more.

THE release of stress chemicals damages brain tissues and plays havoc with your gut bacteria.

Think about breathing breathe out for longer than you breathe in. Listen to music and relax.

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QUALITY sleep is so important for our health.

Getting enough of it helps to keep your in good shape, aids your emotional and mental wellbeing and can even help you maintain a healthy weight.

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Meanwhile, not getting enough sleep or disruptions to your night cycle can lead to fatigue.

Here, Jane Atkinson looks at ways to get enough shut-eye...

MANY aromatherapy essential oils may help to promote relaxation and sleep, and this new gadget is a brilliant way to fill your bedroom with them to help you nod off.

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The Rove Aroma Atomiser scents your space directly from the oil bottle, without the need for water, so you get a potent dose of essential oils.

You simply push an essential oil bottle into the base, switch it to the intensity and run-time you want, for up to 90 minutes.

It charges with a USB and lasts for 30 hours.

It is so dinky I have taken it, with a bottle of lavender essential oils, when I have stayed away from home to help me nod off.

Best to turn off before you actually go to sleep as it does have a little motor noise.

I love this.

It is compatible with 5ml, 10ml and 15ml oil bottles and costs 55. See madebyzen.com.

B-SYNC ON is the first and only supplement designed by sleep science and pharmacological experts to support and improve your wake-up process.

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It contains vitamins B5 and B12 plus zinc and caffeine in a delayed-release capsule.

You take it at bedtime, and about seven hours later it starts to release them into your body.

It is clinically proven to sharpen focus, with feelings of wellbeing upon waking, and helps you transition with ease from sleep to wide awake.

It definitely works my only problem is that I like eight hours kip.

With this, I was awake at 5am after just under seven hours, and there wasnt a chance I was nodding off again.

Good if you only like seven hours, or if you have gone to bed late and know you need to get up early.

23.99 for 20 capsules see b-sync.life.

CHELATED magnesium has been described as the best pill to pop for all-round health.

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It helps to regulate blood pressure, supports the immune system and could reduce a persons risk of heart disease and cancer and boost overall health.

It is easily absorbed by the body and good for tackling fatigue, tiredness and lethargy.

I take it every day and am convinced it helps me sleep better.

Solgar Chelated Magnesium delivers 100mg of magnesium per tablet and costs 13.75 for a bottle of 100.

You do need four a day though!

See solgar.co.uk.

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Take these 10 steps to live a longer life from delaying breakfast to list-making... - The US Sun

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Precision Medicine Software Market, By Delivery Type

On-Premise Cloud-Based

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Rare Diseases Oncology Pharmacogenomics Others

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Pharmaceutical and Biotechnology Companies Healthcare Providers Research Centers and Academic Institutes Others

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Precision Medicine Software Market Size, Scope, Growth Opportunities, Trends by Manufacturers And Forecast ... - This Is Ardee

KEESLER AIR FORCE BASE, Miss. --

The Human Performance Training Center started hosting its first 17 Airmen, July 11, for it's initial pilot program.

Keeslers Human Performance Initiative aims to develop healthy, resilient Airmen that are operational and maintain a high level of readiness.

As a part of the program, Airmen spend two hours a day, five days a week working with the HPI staff for individualized instruction, physical training, and treatment to address thepersonal needs and job requirements.

We want to help Airmen create and maintain healthy and sustainable habits to contribute to the preservation of their long term health and longevity as a warfighter, said Master Sgt. Steven Coon, 81st Diagnostic and Therapeutics Squadron HPI program manager.

The program is modeled after the Comprehensive Readiness for Aircrew Training and Integrated Resilience Optimization Network, but is uniquely tailored to support the development of the Airmen we need in all career fields.

The team supporting the 17 volunteersfor the 120-day program consists of a program manager, strength and conditioning coach, dietitian, physical therapist and physical therapy assistant.

We want to grow this program as much as possible, so every Airman can improve their overall quality of life and mission readiness, said Coon. In the future, wed love to add staff from other domains, such as mental health and research.

The HPI is looking to expand its resources and capabilities to support more Airmen.

Excerpt from:
Propelling Airmen to a higher level of readiness - keesler.af.mil

Bear Grylls is known for his ability to survive inthe most harrowing of conditions. The Man vs. Wild star showedviewers how tolive in the wilderness for five years and seven seasons, so the legendary survivalists' latest enemy comes as a bit of a surprise. Turns out he's got a major aversion to... vegetables. During a recent interview with GQ, the former vegan revealed that he is anti-vegetable. In a shocking revelation, Grylls told GQ that hes abandoned his vegetable-exclusive diet for a carnivore one featuring red meat, dairy, and some fruit.

"Super against nuts. And against grains, wheat, and vegetables," Grylls said. "My lunch is meat, eggs and dairy, a lot of butter, and fruit. I have liver probably every other day."

Grylls revealed that he decided to drop his plant-based diet when he caught COVID-19 approximately two years ago. He claims that he got mega-sore kidneys when he primarily ate vegetables and drank raw juice. Associating this diet with his declining health, Grylls stated without evidence that raw vegetables are really not good for you. He justified this decision by asserting that the human body has evolved to eat meat.

Grylls claims that humans have evolved to eat red meatare debunked by a growing portfolio of research. Examining 1.4 million meat-eaters, one study published last July found that regularly eating red or processed meats increased the risk of heart disease by 18 percent. With heart disease affecting approximately 48 percent of the American population, concerns regarding meat consumption continue to rise nationwide.

Eating partially plant-based is proven to help consumers stay healthy for longer, rather than the carnivore diet championed by Grylls. Last August, one study found that the earlier you incorporate a plant-centered diet, the more likely you are to lower your risk of heart disease nearly 30 years later. Tracking the dietary habit of 5,000 people between 1985 and 2018 revealed how positive a predominantly plant-based diet is for longevity.

Despite Grylls reputation for survival instincts, the carnivore diet presents serious risks to longevity. This February, a study in the PLOS Medicine Journal found that a mostly plant-based diet can prolong life expectancy by over 10 years. This study emphasizedthat regular meat and dairy consumption can lead to fatal diseases including cancers, heart disease, diabetes, and more.

Controversial podcast hostJoe Rogan also advocates for a carnivore diet. Recently, Rogan revealed that he cut out vegetables from his diet in favor of an exclusive meat diet. This happened nearly three years after the host invited The Game Changers producer James Wilks on his show to debate Paleo advocate Chris Kresser. During the interview, Rogan admitted that he was impressed with Wilks evidence for the plant-based diet, stating that he considered taking down his original critical review of the film.

[James Wilks] one of the producers of The Game Changers came on to challenge some of the criticism that Chris Kresser presented about the movie, and to say he did well would be a tremendous understatement. Rogan wrote on Instagram at the time. James knocked it out of the park and defended himself and the film quite spectacularly. So much so that Im actually considering taking the original breakdown of the film offline.

Grylls and Rogans affinity for the carnivore diet potentially deprives them and other dieters of essential plant-based nutrients like polyphenols and fiber. Red meat consumption can also lead to inflammation, slow recovery times, and difficulty losing weight. Although a significant source of protein, the carnivore diet excludes a significant amount of important nutrients.

Check out these 9 surprising ways that eating meat is harmful to your health.

For more plant-based happenings, visit The Beet's News articles.

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Bear Grylls Says He's Anti-Vegetable. Here's What Science Says - The Beet

It seems that Elon Musk is the man of 2022 but not exactly all for good reasons. Recently, its been reported that the Tesla founder might have an extramarital affair with Google co-founder Sergey Brins wife, Nicole Shanahan.The news broke after The Wall Street Journal reported that his friendship with Brin had ended over the alleged affair.

Elon Musk has been accused of having an affair with Sergey Brins wife, Nicole Shanahan. Photos: AFP, @KaiseratCB/TwitterMusk has denied the allegations and wrote a reply on Twitter saying it was total BS, adding that hes still very much friends with the Google co-founder and was even at a party with him the night before. He said hes only seen Shanahan twice in three years and both times with many people around. Nothing romantic.

The Wall Street Journal, however, reported that Musk had an affair with Shanahan late last year that led to her divorce with Brin earlier this year which is still ongoing also supposedly ending Brin and Musks long friendship.

Tesla CEO Elon Musk attends the groundbreaking ceremony of Tesla Shanghai Gigafactory in Shanghai, east China, in January 2019. Photo: Xinhua/Zuma Press/TNSSo, what do we know about the mysterious Nicole Shanahan, the 33-year-old at the centre of the worlds richest man and his fellow multibillionaires would-be rift?

Nicole Shanahan and Sergey Brin got married in 2018. Photo: @MelaynaLokosky/TwitterShe is a lawyer and a tech guruAlthough she has links to billionaires, Shanahan is a woman of her own accord. She is a lawyer and founded ClearAccessIP in 2013 a firm based in Palo Alto that helps patent owners manage and monetise their intellectual property rights, reported The Straits Times. She sold the company in 2020 and its since been acquired by rival IPwe for an undisclosed amount.

Nicole Shanahan is a research fellow at CodeX. Photo: Stanford UniversityOn the legal front, the graduate of Santa Clara University School of Law is also a research fellow at CodeX, the Stanford Centre of Legal Informatics, a joint centre between Stanford Law School and Computer Science, per her LinkedIn page.

Nicole Shanahan graduated from Santa Clara University School of Law. Photo: @NicoleShanahan/TwitterHer profile also states that she specialises in the legal applications of neural networks, structured databases, APIs, UI/UX, automation and SaaS. Away from the tech world, Shanahan is also working on an economic theory called Coasean Mapping to predict the pace and nature of societys adoption of legal artificial intelligence. Take that, haters!

Nicole Shanahan is a tech whizz in her own right. Photo: Stanford UniversityShe is also a philanthropistAfter she sold her company, Shanahan founded Bia-Echo in 2019. The foundation focuses mainly on reproductive longevity and equality along with criminal justice reform and to preserve a healthy and liveable planet.

Her interest in reproductive longevity ties to her own personal struggle to get pregnant, according to The Chronicle of Philanthropys website. Her foundation partnered with the Buck Centre for Reproductive Longevity and Equality as well as with the National University of Singapores Yong Loo Lin School of Medicine.

Nicole Shanahan has publicly opened up about her fertility struggles in the past. Photo: @ACRLE_NUS/TwitterLike many women who are not quite ready to start a family in their early 30s, I decided, or so I thought at the time, to take matters into my own hands and freeze embryos. However, after three failed attempts at embryo-making and three dozen visits to in vitro fertilisation clinics around the Bay Area, I learned that I was not nearly as unshakeable as I thought I was, she said in an interview, per the New York Post.

Meanwhile, her interests in social justice stem from her own belief that criminal justice reform will be this generations biggest topic. She told Modern Luxury that she donated to Measure J in Los Angeles County, which will divert its law enforcement budget towards mental and social support services.

Nicole Shanahan and Sergey Brin attended several events together. Photo: @WorldFishNews/TwitterI want to get the word out and assure everyone that I am committed as ever to dedicating my lifes work to social justice, climate solutions and a thoughtful, caring democracy, Shanahan said in an interview with Puck recently.

She told the same publication that she wants her legacy to be in the form of ideas and wants it to be about evolving the human experience on this planet with strength, love and compassion.

Nicole Shanahan and Sergey Brin share a child together. Photo: @drewaltizerphotography/InstagramShe reportedly seeks a US$1 billion divorce settlement Brin and Shanahan reportedly met for the first time at a yoga retreat in 2015, but didnt make their relationship official until 2016s Met Gala, according to The Wall Street Journal. They got married in 2018 and welcomed a daughter together the same year. They reportedly ended their marriage in late 2021, though the divorce terms are yet to be finalised.

Nicole Shanahan, left, and Sergey Brin attend the 2020 Breakthrough Prize Red Carpet at Nasa Ames Research Center in November 2019, in Mountain View, California. Photo: Getty Images/TNSAccording to multiple reports, Shanahan and Brin are in the midst of negotiating the divorce settlements. She signed a prenuptial agreement and is reportedly seeking a settlement of more than US$1 billion, according to The WSJ. Brin cited irreconcilable differences as the reason for their divorce and is seeking joint custody of their daughter. He is not seeking spousal support for Shanahan, requesting she not be awarded any either.

Anne Wojcicki and Sergey Brin presenting at the 2014 Breakthrough Prizes Awarded in Fundamental Physics and Life Sciences Ceremony at Nasa Ames Research Center, in December 2013, in Mountain View, California. Photo: Getty ImagesThe Google co-founder himself was previously married to 23andMe co-founder Anne Wojcicki from 2007 to 2015. They share son Benji, 13, and daughter Chloe, 11.

Nicole Shanahan has Chinese roots. Photo: JoroShe had a rough childhoodShanahan might enjoy a high-profile life today, but it was not always easy for the techpreneur. Born to a Chinese immigrant mother and a father struggling with mental health issues, Shanahan had to mature faster than other kids.

My dad was diagnosed with bipolar [and] schizophrenia when I was nine, and my Chinese-born mom had only been in the US for two years when I was born. I had two unemployed parents for the majority of my childhood, so not only was there no money, there was almost no parental guidance, and as you can imagine with a mentally ill father, there was lots of chaos and fear, she told San Francisco magazine in 2021.

Nicole Shanahan grew up under difficult conditions. Photo: News UnzipShe also shared how public assistance got her through the hard times. When you lack access to resources, you really learn how to live with suboptimal infrastructure, she said. So, I learned how to compete in really creative ways by making broken objects perform at levels beyond their perceived capacity.

In the interview, she also opened up about how she bused tables when she was just 12 and loves the internet: Without the internet I would probably still be in Oakland doing the same thing I was doing at age 12.

Nicole Shanahan credits the internet for her career boost. Photo: Bia EchoShe had an unfortunate #MeToo experienceWhile working for a company called RPX Corporation in her mid-20s, Shanahan experienced sexual assault.

It wasnt until the #MeToo movement that I felt comfortable discussing this, but while I was at this job, a male co-worker sexually assaulted me one evening while we were working on a project, she said in the San Francisco magazine interview.

Because the company at the time was all male-led, and this co-worker was highly regarded by the management, he continued to advance more quickly than I did, even though I was the one doing most of the work on our projects, she added.

Nicole Shanahan experienced sexual assault in her mid-20s. Photo: KiddaanAfter the incident, Shanahan suffered from severe depression and had to quit her job to move in with an aunt in Berkeley. She revealed that her biggest regret today was that she didnt report what had happened, as the perpetrator had also assaulted other female employees at the company.

No one understood why I had left and I dont think that I even understood what was happening to me, she revealed.

Nicole Shanahan and Sergey Brin are a combination of two great tech minds. Photo: @KaiseratCB/TwitterHowever, as the strong and persistent woman she is, Shanahan managed to overcome her trauma and founded her AI-enabled patent management company afterwards.

The Silicon Valley entrepreneur has also pledged US$100 million to womens reproductive rights and criminal justice reform through her foundation.

And I actually think that as I move forward out of this separation, I feel very optimistic in how I might grow in this role, she told Puck News.

Note: This story was originally published on SCMP and has been republished on this website.

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Beyond the Elon Musk hook-up scandal - Meet the real Nicole Shanahan - The 33 year old is a tech whiz and a lawyer who had very humble beginnings and...

In Vatican diplomacy, balancing the prophetic witness of the faith, the internal relationships of the local Church, and the realities of statecraft is a challenge.

Vatican diplomats often have to walk a fine line in what they say publicly, none more so than the Secretariat of States foreign minister, Archbishop Paul Gallagher, who has led the departments diplomatic section since 2014.

For much of the last eight years, Archbishop Gallagher has appeared to be a model of diplomatic restraint, limiting his public statements and choosing his words carefully. He has also been, at times, a dogged defender of Vatican diplomatic efforts, pushing back on public criticism on controversial issues like the Vatican-China deal, and stressing the Holy Sees reliance on private discussions, away from the public eye.

Yet, in recent days, Gallagher has appeared to strike a more frank tone, offering measured but pointed criticism on some of the most contentious topics in the Churchs internal and external relations. But what prompted this change in tone from the Vaticans chief diplomat, and what might it signal about the Holy Sees internal thinking?

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In an interview with the official outlet of the German bishops conference published on Wednesday, the normally circumspect Gallagher discussed the Vaticans relationship both with the German government and the German bishops conference.

The archbishop seemed clear that the Holy See enjoyed a far easier and more positive relationship with the civil government, led by a Catholic who publicly renounced the faith, than it did with the local bishops.

We are very concerned right now about the direction that the Church in Germany seems to be taking at the moment, Gallagher said. Of course, this also has an impact on our work. This has an impact on how the German state sees the Holy See and the Catholic Church - and vice versa.

The archbishop went on to suggest archly that the German Church should ask itself some tough questions about its considerable wealth, stemming from billions in state-collected tax revenues, and its effect on the local bishops.

The remarks were striking, even in the context of recent Vatican interventions against the German synodal process.

Gallaghers pointed comments about the influence of money on the German bishops were even more striking, given he went on to point out it wasnt an issue that related to the secretariats work. In June last year, the archbishop drew scrutiny for saying that the Holy Sees diplomatic department didnt talk about issues it didnt think it could affect by doing so even to the point of remaining silent on the human rights crisis in China and Hong Kong.

But on China, too, Gallagher has taken a suddenly more robust public stance.

Speaking about the controversial Vatican-Beijing deal, which the pope recently said he expects to see renewed in October, Gallagher candidly admitted in an interview last week that the balance sheet, I suppose, is not terribly impressive.

Despite his stance last year that Vatican diplomats didnt talk about human rights and Hong Kong, Gallagher also weighed in on the arrest of Cardinal Joseph Zen earlier this year, telling America magazine that the Vatican wanted to see Zens case resolved satisfactorily in the near future, and acknowledged Hong Kong Bishop Stephen Chows statements on civil liberties in the special administrative region.

The Holy See is committed to the defense of religious freedom, Gallagher affirmed, including in Hong Kong.

While these statements are hardly provocative in themselves, they all represent a noticeable sharpening of tone by the Vatican foreign minister and a real, if subtle, shift in the way he addresses the most sensitive issues facing the Vatican right now.

And they are not the only sensitive topics Gallagher has addressed with sudden candor.

For months, the Vatican, and Pope Francis personally, have beaten back against furious media speculation about his health and longevity, and insisting, pain in his knee notwithstanding, that the pope is otherwise in rude health and set to continue in office indefinitely.

But, speaking to the German bishops official outlet about the popes future plans, Gallagher noted that other proposed trips presented a great challenge, also for the health of the Holy Father.

Of course, the time he has left is limited, Gallagher observed when asked about the prospects of Francis visiting European countries like France or Germany.

The pope is, of course, 85 years old, and acknowledging that there are fewer days ahead than behind in his pontificate is just stating the obvious. Nevertheless, its an obvious truth the Vatican has been at pains to deflect from aknowledging in public.

Even if the shift is subtle, the Holy Sees senior diplomat suddenly becoming casually frank about Germany, China, and the limited time left to Pope Francis marks a real change. But what is driving it?

One possibility is that it is a calculated change in tone from the Secretariat of State itself.

Gallaghers interview with the German bishops own news service comes hot on the heels of an unsigned statement from Rome about their synodal way, interpreted by some German Catholics as the Vatican pulling the emergency brake.

Similarly, while Pope Francis has remained bullish on reviewing the controversial Vatican-China deal, the Secretariat of State has quietly filled its vacant senior posts in Taiwan and Hong Kong in recent weeks, suggesting it has drawn a line under the idea of more formal diplomatic links to Beijing for the time being.

It could be that Archbishop Gallagher is deliberately tipping the Vaticans hand on German and China as a show of resolve, perhaps in an effort to forestall any further moves by the German bishops to upend their ecclesial structures or by the Chinese to tighten their grip on the Church in Hong Kong.

Together with a sudden frankness about Pope Francis longevity, it might even be meant to signal the institutional commitments of the Vatican, beyond the current pontificate.

It is equally possible that Gallagher is freelancing with his change of tone, perhaps in the expectation he is soon to change jobs. While Vatican officials normally work to five year appointment terms, many of the senior roles below prefect turn over on a different schedule.

The 68 year-old Englishman is approaching eight years in post, the same amount of time served by his predecessor, Dominique Mamberti, whom Pope Francis made a cardinal in 2014 and appointed to lead the Supreme Tribunal of the Apostolic Signatura. When Cardinal Angelo Becciu was made a cardinal by the pope and appointed to lead the then-Congregation for the Causes of Saints, he had served seven years as sostituto at the Secretariat of State, a term he has said was already longer than usual for the role.

At the end of August, Pope Francis is set to convene a consistory in Rome to formally elevate the most recent slate of newly named cardinals and discuss the principles of his new apostolic constitution for the Roman curia, Praedicate Evangelium.

There is widespread expectation in the Vatican that shortly afterwards, in the first weeks of September, Francis will announce a reshuffle in the leadership of several departments, including the dicasteries for bishops, Catholic education, and for Eastern Churches.

With new appointments expected, and new vacancies arising as a result, it is possible Gallagher expects to be moved from his current role and his recent interventions are signs of a kind of end-of-term relaxation on his part.

Whether calculated or casual, what is certain is that Archbishop Gallaghers change in tone isnt meaningless. And what he talks about in the coming weeks, and how he talks about it, should make for interesting reading.

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What's behind the Vatican chief diplomat's change of tune? - The Pillar

The raw food diet has gotten the attention of pet owners in recent years.

One of the most popular raw food diets for petsis called Biologically Appropriate Raw Food, or BARF for short. Created in the 1990s, BARF mimics the diet of a wild animal with meat, bones, vegetables and other raw foods. The diet claims to bring dogs back to their non-domesticated way of feeding and boasts benefits like growth, better health and longevity.

But is the diet for dogs? Can your furry friend maintain a healthy lifestyle by eating raw meat? Heres what you need to know.

Yes, technically, dogs can eat raw meatbut that doesnt mean they should.

According to Soma Technology, animals, particularly wild ones, have a stronger stomach acid,helping them digest food and kill off parasites and bacteria found in raw meat. Before dogs were domesticated, their diet contained raw meat like most animals.

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Common proteins in a raw meat diet include eggs, bones milk and these meats:

One type of meat dog owners should be aware of is denatured meat, sometimes called 3D or 4D meat. This meat typically comes from dying, dead or diseased animals, Rogue Pet Science writes. While being processed, this meat isoften deemed unfit for human consumption and ends up in pet food. It's a legalbut dangerous factbecause of the bacteria and chemicals used in manufacturing.

The American Veterinary Medical Associationcautions against feeding your dog raw meat because it doesnt provide the balanced nutrition your canine companion needs in their diet.

Eating raw meat regularly can increaserisk of nutritional deficiencies.A 2011 study from Cambridge University found 60% of dogs on a diet of bones and raw food had nutritional imbalances.

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Proportions are key: How much food you should be feeding your dog

Most veterinarians advise against giving dogs raw diets for the same reason humans dont eat raw meat there are health risks when it comes to the bacteria found in raw food. The Centers for Disease Control and Prevention warns pet owners about raw diets because of bacteria, like salmonella and listeria, which can be found in raw pet food, even packaged meats in stores.

According to a study from the University of California, Davis, there is little to no scientific support in favor of the raw diet. Research suggests canned diets and kibble, as well as home-cooked meals, are beneficial to your pets nutritional intake. In this case, the risks far outweigh any potential benefits of a raw meat diet.

Raw food diets can also be potentially harmful for dog owners and their families. You could be subject to food poisoning or sickness by just handling raw food or taking care of your pet.

If you do decide to feed your dog raw meat, the CDC recommends keeping it frozen and thawing in the fridge until use. Make sure to disinfect all surfaces the raw meat touched, and avoid playing with your pet directly after they eat.

Your pet licking your face or mouth is a playful gesture of affection that can turn risky after theyve gobbled down raw meat. The CDC recommends exercising extra caution around young children and raw meat because their immune systems are not fully developed.

Just curious?: We're here to help with life's everyday questions

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Can dogs eat raw meat? The risks and rewards of putting your pup on a raw food diet. - USA TODAY

image:Copenhagen to Host Gathering of Top Aging Researchers in Biopharmaceutical Industry view more

Credit: insilico

July 18, 2022: From Aug. 29-Sept. 2, 2022, the 9th annual Aging Research and Drug Discovery (ARDD) conference will be held at the University of Copenhagen and virtually and is expected to exceed the number of 2021 delegates with a year-over-year growth of on-site delegates exceeding 300%. During the pandemic, the conference remained open and attracted thousands of participants both on-site and online.

In addition to leading academic and industry speakers, the conference attracts prominent startups, venture capitalists, and editors of major industry journals, including Nature Aging and other Nature journals, Lancet Healthy Longevity, Frontiers, Aging, eLife, and others.

Since its inception, ARDD has prioritized academic excellence, credibility, and value for the biopharmaceutical industry as the main virtues for both the speakers and the delegates, says Alex Zhavoronkov, PhD, co-chair of the 9th ARDD and founder and CEO of Insilico Medicine, an artificial intelligence (AI)-driven end-to-end drug discovery company. This conference was designed to create the worlds first platform for the pharmaceutical industry to actively engage in and incorporate the latest discoveries in credible aging research into every aspect of their internal R&D strategy. I am very happy that the 9th ARDD in Copenhagen has taken these already high standards even higher and the conference has scaled to become the largest global event of this kind.

The quest to combat aging is gaining momentum with many new technologies including aging clocks, senolytics, AI-discovered and AI-designed antifibrotics, and other geroprotectors being adopted by academic researchers, startups, and pharmaceutical companies. Despite the general slowdown in the biotechnology industry, the subsector focusing on longevity biotechnology is growing exponentially with significant new funding commitments from venture capitalists, the pharmaceutical industry, new private foundations, and government institutions.

Insilico was one of the first companies to recognize this trend. In 2014, the same year the company was founded, Dr. Zhavoronkov brought together a large group of aging researchers and pharmaceutical company executives at the Aging Forum as part of the Miptec/BaselLife conference in Basel, Switzerland. In 2019, Professor Morten Scheibye-Knudsen, MD, PhD, the head of the Biology of Aging laboratory at the University of Copenhagen, joined the ARDD as executive chair and brought the conference from Switzerland to Copenhagen.

The nonprofit conference is managed by the University of Copenhagen with Insilico Medicine as co-organizer and sponsor. This year, Boston Consulting Group will join the conference as a Knowledge Partner with BCG Managing Director and Senior Partner Michael Ringel, JD, PhD, participating as a speaker.

Other 2022 ARDD speakers include: Mehmood Khan, MD, CEO of Hevolution Foundation; Andrea B. Maier, MD, Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research, and Co-Director of the Centre for Healthy Longevity; Vadim Gladyshev, PhD, Professor of Medicine at Harvard Medical School; Vishwa Deep Dixit, DVM, PhD, Waldemar Von Zedtwitz Professor of Pathology and Professor of Immunobiology and Director of the Yale Center for Research on Aging (Y-Age); Evelyne Bischof, MD, Associate Professor at Shanghai University of Medicine and Health Sciences; and Joan Mannick, MD, co-founder and CEO of Tornado Therapeutics, among many others.

Additional sponsors of the event include: Rubedo Life Sciences, Gordion, Cambrian, Rejuveron, Bioage, Gameto, Molecule, VitaDao, Foxo Technologies Inc., Longe VC, TruDiagnostic, Apollo Health Ventures, Oisin Biotechnologies, Rejuvenate Biomed, GlycanAge, Deep Longevity, Frontiers in Aging, and Longevity Center.

Despite the pandemic and the shocking conflict on the European continent, the ARDD 2022 conference will be held in person at the University of Copenhagen, said Dr. Scheibye-Knudsen. We are extremely excited about the program and the possibility of meeting friends and colleagues outside of Zoom. This year, we are maintaining our focus on young scientists who will be the future of our field. We have a large number of speaker slots for these rising stars."

Highlights of this years conference include an Emerging Tech Workshop that will explore the growth of scientific collaboration in blockchain, artificial intelligence, and robotics. Through the Student Ambassador Program, teenage researchers with an interest in aging and drug discovery are paired with experts and receive mentorship and insight as well as conference registration.

In March, Aging published a paper showing how Insilico Medicine used its drug discovery platform, PandaOmics, to identify 145 aging-related therapeutic targets across various age-related diseases like Alzheimers, Parkinsons, and osteoarthritis in under two months. These were further narrowed down into nine highly promising dual aging-and-disease targets. By training deep neural networks on human omics data, the company was able to generate massive quantities of synthetic data with age as a generation condition and use these DNNs to better understand human disease and aging biology. Insilico now has the first AI-discovered and AI-designed drug in Phase 1 trials for idiopathic pulmonary fibrosis.

The ARDD conference is designed to highlight these sorts of breakthroughs and foster new collaboration among aging researchers to drive discoveries forward.

This years discussion topics include: translating geroscience into the clinic; longevity medicine therapeutics; longevity medicine diagnostics and interventions; tissue immunology and repair; and the biochemistry uniting infectious disease and aging, among many others.

Aging research is growing faster than ever on both academia and industry fronts, said Daniela Bakula, PhD, University of Copenhagen. The ARDD meeting unites experts from different fields and backgrounds, sharing with us their latest groundbreaking research and developments.

Details and registration: http://www.agingpharma.org/

For further information, images or interviews, please contact: ardd@insilico.com

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70+ leaders in aging and longevity to present at the 9th ARDD Conference - EurekAlert

The research team also discovered that protective phenotypes, like the hard shells of most turtle species, might delay the aging process and, in some circumstances, even stop biological aging.

Jonathan the Seychelles giant tortoise, who is 190 years old, made headlines recently for being the oldest living land animal in the world. Although there is anecdotal evidence that certain species of turtles and other ectotherms, or cold-blooded creatures, live a long life, this evidence is spottyand mostly focuses on animals kept in zoos or a small number of individuals surviving in the wild. The largest study on aging and lifespan to date, conducted by an international team of 114 scientists and directed by Penn State and Northeastern Illinois University, has recently been published. It contains data gathered in the wild from 107 populations of 77 different species of reptiles and amphibians.

A photo of a painted turtle (Chrysemys picta), a widespread North American species of freshwater turtle. Credit: Beth A. Reinke, Northeastern Illinois University

The researchers discovered several things, including for the first time, that salamanders, crocodilians, and turtles had extremely slow aging rates and prolonged lifespans for their sizes. They recently published their results in the journal Science. The research team also discovered that protective phenotypes, such as the hard shells of the majority of turtle species, lead to slower aging and, in certain circumstances, even to negligible aging, or the absence of biological aging.

Anecdotal evidence exists that some reptiles and amphibians age slowly and have long lifespans, but until now no one has actually studied this on a large scale across numerous species in the wild, said David Miller, senior author and associate professor of wildlife population ecology, Penn State. If we can understand what allows some animals to age more slowly, we can better understand aging in humans, and we can also inform conservation strategies for reptiles and amphibians, many of which are threatened or endangered.

In their study, the researchers used mark-recapture data, in which animals are taken, tagged, released back into the wild, and then watched, in conjunction with comparative phylogenetic approaches, which allow forinvestigation of organisms evolution. Their purpose was to compare ectotherm aging and lifespan in the wild to endotherms (warm-blooded animals) and investigate earlier assumptions about aging, such as manner of body temperature control and the presence or absence of protective physical features.

The face of a tuatara (Sphenodon punctatus). Credit: Sarah Lamar

Miller explained that the thermoregulatory mode hypothesis suggests that ectotherms because they require external temperatures to regulate their body temperatures and, therefore, often have lower metabolisms age more slowly than endotherms, which internally generate their own heat and have higher metabolisms.

People tend to think, for example, that mice age quickly because they have high metabolisms, whereas turtles age slowly because they have low metabolisms, said Miller.

The teams findings, however, reveal that ectotherms aging rates and lifespans range both well above and below the known aging rates for similar-sized endotherms, suggesting that the way an animal regulates its temperature cold-blooded versus warm-blooded is not necessarily indicative of its aging rate or lifespan.

We didnt find support for the idea that a lower metabolic rate means ectotherms are aging slower, said Miller. That relationship was only true for turtles, which suggests that turtles are unique among ectotherms.

The protective phenotypes hypothesis suggests that animals with physical or chemical traits that confer protection such as armor, spines, shells, or venom have slower aging and greater longevity. The team documented that these protective traits do, indeed, enable animals to age more slowly and, in the case of physical protection, live much longer for their size than those without protective phenotypes.

It could be that their altered morphology with hard shells provides protection and has contributed to the evolution of their life histories, including negligible aging or lack of demographic aging and exceptional longevity, said Anne Bronikowski, co-senior author and professor of integrative biology, Michigan State.

Beth Reinke, first author and assistant professor of biology, at Northeastern Illinois University, further explained, These various protective mechanisms can reduce animals mortality rates because theyre not getting eaten by other animals. Thus, theyre more likely to live longer, and that exerts pressure to age more slowly. We found the biggest support for the protective phenotype hypothesis in turtles. Again, this demonstrates that turtles, as a group, are unique.

Interestingly, the team observed negligible aging in at least one species in each of the ectotherm groups, including frogs and toads, crocodilians, and turtles.

An Iberian tree frog (Hyla molleri). Credit: Iigo Martnez-Solano

It sounds dramatic to say that they dont age at all, but basically their likelihood of dying does not change with age once theyre past reproduction, said Reinke.

Miller added, Negligible aging means that if an animals chance of dying in a year is 1% at age 10, if it is alive at 100 years, its chance of dying is still 1%. By contrast, in adult females in the U.S., the risk of dying in a year is about 1 in 2,500 at age 10 and 1 in 24 at age 80. When a species exhibits negligible senescence (deterioration), aging just doesnt happen.

Reinke noted that the teams novel study was only possible because of the contributions of a large number of collaborators from across the world studying a wide variety of species.

Being able to bring these authors together who have all done years and years of work studying their individual species is what made it possible for us to get these more reliable estimates of aging rate and longevity that are based on population data instead of just individual animals, she said.

Bronikowski added, Understanding the comparative landscape of aging across animals can reveal flexible traits that may prove worthy targets for biomedical study related to human aging.

Reference: Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity by Beth A. Reinke, Hugo Cayuela, Fredric J. Janzen, Jean-Franois Lematre, Jean-Michel Gaillard, A. Michelle Lawing, John B. Iverson, Ditte G. Christiansen, Iigo Martnez-Solano, Gregorio Snchez-Montes, Jorge Gutirrez-Rodrguez, Francis L. Rose, Nicola Nelson, Susan Keall, Alain J. Crivelli, Theodoros Nazirides, Annegret Grimm-Seyfarth, Klaus Henle, Emiliano Mori, Gatan Guiller, Rebecca Homan, Anthony Olivier, Erin Muths, Blake R. Hossack, Xavier Bonnet, David S. Pilliod, Marieke Lettink, Tony Whitaker, Benedikt R. Schmidt, Michael G. Gardner, Marc Cheylan, Franoise Poitevin, Ana Golubovi, Ljiljana Tomovi, Dragan Arsovski, Richard A. Griffiths, Jan W. Arntzen, Jean-Pierre Baron, Jean-Franois Le Galliard, Thomas Tully, Luca Luiselli, Massimo Capula, Lorenzo Rugiero, Rebecca McCaffery, Lisa A. Eby, Venetia Briggs-Gonzalez, Frank Mazzotti, David Pearson, Brad A. Lambert, David M. Green, Nathalie Jreidini, Claudio Angelini, Graham Pyke, Jean-Marc Thirion, Pierre Joly, Jean-Paul Lna, Anton D. Tucker, Col Limpus, Pauline Priol, Aurlien Besnard, Pauline Bernard, Kristin Stanford, Richard King, Justin Garwood, Jaime Bosch, Franco L. Souza, Jaime Bertoluci, Shirley Famelli, Kurt Grossenbacher, Omar Lenzi, Kathleen Matthews, Sylvain Boitaud, Deanna H. Olson, Tim S. Jessop, Graeme R. Gillespie, Jean Clobert, Murielle Richard, Andrs Valenzuela-Snchez, Gary M. Fellers, Patrick M. Kleeman, Brian J. Halstead, Evan H. Campbell Grant, Phillip G. Byrne, Thierry Frtey, Bernard Le Garff, Pauline Levionnois, John C. Maerz, Julian Pichenot, Kurtulu Olgun, Nazan zm, Aziz Avc, Claude Miaud, Johan Elmberg, Gregory P. Brown, Richard Shine, Nathan F. Bendik, Lisa ODonnell, Courtney L. Davis, Michael J. Lannoo, Rochelle M. Stiles, Robert M. Cox, Aaron M. Reedy, Daniel A. Warner, Eric Bonnaire, Kristine Grayson, Roberto Ramos-Targarona, Eyup Baskale, David Muoz, John Measey, F. Andre de Villiers, Will Selman, Victor Ronget, Anne M. Bronikowski and David A. W. Miller, 23 June 2022, Science.DOI: 10.1126/science.abm0151

The study was funded by the National Institutes of Health.

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Secrets of Longevity Revealed: Scientists Find Species That Essentially Do Not Age - SciTechDaily