Category Archives: Human Longevity

Tom Brady is 43 years old now, and in some ways his age is showing. His hair is a little more salt and pepper than it once was, theres a few more wrinkles here and there, his legs arent as nimble. Entropy happens to us all.

Tom Brady is also a 43 year old who has one of the best diets a human can have and still plays the game of football at a high level. The now Tampa Bay Buccaneers quarterback is the greatest QB of all time. With 6 Super Bowl rings and 9 appearances overall, thats a topic that shouldnt even be a discussion present day. Even when youve received all the accolades of yesteryear like Brady has, he still has to continuously prove himself once more.

Just like most times in his career when he struggled, Brady battled back. He turned things around during the game. The Bucs faced a 17-point deficit, but being behind by that score isnt something that is going to make Brady put his head down. Instead, Brady ended up having one hell of a second half. Brady completed 15 of 17 passes in the second half for 263 yards, 3 touchdowns with a perfect 158.3 passer rating. Tampa won 38-35. Brady threw 5 touchdowns to 5 different receivers, the first time hes done that in a game in his career.

Bradys passes still have a lot of zip on them, he can still deliver an accurate deep ball. His mental prowess is unparalleled. Hes Tom effin Brady. Not much has changed. Hes still someone you dont want to go toe-to-toe with in Week 4, and definitely not in the playoffs.

Its quite hilarious to see some of the narratives play out when Brady makes any error. Those reactions tend not to age well. Weve seen this for the better part of a decade now, and Brady keeps proving doubters wrong. Beyond Bradys love for the game, the fact he still has to prove himself is reason enough for him to keep playing.

In a relatively weak looking NFC, Brady and the Buccaneers have a realistic shot at making the Super Bowl. With that in mind, now would be a good time to stop doubting Tom Brady and his longevity. Instead, appreciate greatness and look into what the hell hes doing to stay so physically fit and healthy. The TB12 method seems to be working.

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Doubting Tom Bradys longevity never ages well - Maize n Brew

City trees lead difficult lives. A lot of things are trying to kill them, particularly the trees planted on sidewalks: Tightly compacted soil with high alkaline content makes it harder for them to absorb nutrients. Tiny plots of land admit very little rainwater. Theyve got dogs peeing on them, people dropping cigarette butts nearby, and cars belching pollution.

Were talking about trees that are very vulnerable, says Nav Strauss, the head of street-tree planting for New York City. His team manages the planting of new trees on streets and public rights of way; there are more than 666,000 street trees in the city, and the team plants about 16,000 new ones annually. For decades, New York arborists have tended to prefer tough, hardy species that thrive well against adversitysuch as the London planetree, which sports grayish bark and big, maple-like leaves that offer sidewalks tons of shade.

But lately, Strauss has been looking for trees that can handle an even tougher challenge: climate change.

In the past century, the United States has heated up as much as 1.9 degrees Fahrenheit. The natural cycle of cities is already being pushed in new directions; in New York, spring now begins a week earlier than in the 1950s. Current predictions suggest that the temperature in the city will rise by up to 6 degrees by the 2050s, and up to 10 degrees by the 2080s. This hotter climate will bring longer periods of drought too. That will require some entirely new trees that can survive, and thrive, in the decades to come.

One stands out: Theres this crazy tree out in Arizona, where it's highly, highly dry, Strauss told me. A few of its relatives, the northern catalpa, have already migrated to New York and thrived, sporting huge leaves and flowers. Youll see them growing in vacant lots, where youd be likeWheres their food source? he laughed. Thats why he thinks this new hybrid ought to be able to handle the coming droughts. So he pulled the trigger, and 10 of them went into the ground. Within a few years, Strauss and his team will know whether this tree will be a useful part of New Yorks warmer, weirder climate.

Read: Trees have their own songs

Urban foresters think a lot about their cities distant future, because when you plant trees, you have to. A well-maintained tree in an urban park can last 150 years or longer. A sidewalk tree lives a shorter period, but it still might get 30 years or more. So a city arborist is always thinking: Whats this city going to be like 20 years from now? Or 50? Or 100? Trees are time machines, connecting us to the future.

American cities are host to 3.8 billion treeson sidewalks, in parks, in our front yards and backyards, outside houses of worship and office complexes. Theyre crucial for urban life: Most notably, trees cool down cities by creating shade and engaging in transpiration, the process by which they return water vapor into the atmosphere. Together, these effects can lower the temperature of a city street a few degrees (and as much as 10 degrees, as one recent study found). Studies have also found that well-placed trees can reduce air-conditioning costs by about one-third. Trees also remove up to 24 percent of dust; studies show that kids who live near urban trees have lower rates of asthma. Trees can even make pavement last a decade longer.

If cities want to keep those benefits, theyve got to plan for a future with a different, more hostile climate. As cities heat up, they effectively become different places, where a species that has persisted for hundreds of years can no longer thrive. By some estimates, the habitable zones for 130 of the countrys tree species could move north by more than 400 miles by the end of the century. New invasive species will arrive. Unless cities continually adapt, these shifts could significantly erode their tree canopies, making urban landscapes uglierand more unlivable.

If you wander around Louisville, Kentucky, youll find trees tucked in nooks all oversome dotting the downtown sidewalks, big clusters of mature ones along the snaky banks of the Ohio River, and even a few young trees adding a splash of green in front of the KFC Yum! Center sports complex.

But those trees are in danger. After an assessment of its urban forest in 2015, the local government discovered that the city was losing its canopy at a startling rate of 54,000 trees a year. The reasons for the decline are multifaceted, ranging from real-estate development to disease. The emerald ash borer, an invasive Asian beetle species that has been on a rampage across the United States, poses a particular problem. It destroys ash, a tree commonly planted in urban areas because of its good leaf cover and (normally) hardy nature. More than one in 10 trees in Jefferson County, where Louisville is located, are ash.

But on top of those problems, Louisvilles rate of heating is intense: Research by Brian Stone, the director of the Urban Climate Lab, discovered that Louisville had the fastest-growing urban heat-island effect of any other American city he and his team had studied.

Big red flag, big red flag, says Cindi Sullivan, a horticulturalist who used to work for the city and is now the executive director of TreesLouisville, a group that funds tree planting across the city. On top of regular climate warming, Louisville has the curse of geography; its in the Ohio Valley, and the air will tend to kind of hang, as Sullivan told me. Unfortunately, thats why were also called the allergy and asthma capital of the world. Some of the citys local climate change can likely be attributed to the loss of trees. Trees are, in effect, lo-fi geoengineering on an urban scale. Plant them, and things cool down; remove them, and things heat up.

Read: The best technology for fighting climate change? Trees

So Louisville needs to plant more trees, and ones that are future-proofed. This means working with private citizens, because in Jefferson County, most of the trees arent on public land such as streets or parks. Fully 70 percent grow on private property, rooted in peoples yards. Rebuilding the canopy thus means making it as easy as possible for everyday citizens to plant a new tree; among other things, Sullivans group raises money to subsidize all this planting. It connects residents with software from the Arbor Day Foundation that lets a Louisville resident find the best place on their property to plant a tree thatll provide maximum shade and energy savings.

But which species of tree will survive Louisvilles emerging climate? Lately, Sullivans group has been looking for trees that are native a bit farther south, such as Ulmus crassifolia, the cedar elm. It produces a big cloud of oval leaves, offering terrific shade, and its also good at dealing with drought.

And drought resistance is maybe even more important than heat resistance, if you want a tree thats future-proof. Under climate change, city planners note, their precipitation is increasingly arriving in bursts; they get longer jags with less rain, followed by torrential downpours. When weather becomes spiky like that, a healthy urban canopy is even more crucial to have around, because trees help reduce the runoff that would otherwise overwhelm a citys drain system. But the catch is finding a tree that can handle those erratic, feast-or-famine rainfall patterns. Crassifolia, Sullivan thinks, fits the bill for Louisville, and, as a bonus, its aesthetically interesting. Its a really cool tree, she told me. It has quirky bark, quirky stemthere are these ridges that fall all along the branches and stems.

On a personal level, Sullivan also has high hopes for the zydeco twist, a species of black gum she planted at her own Louisville home nine years ago. The zydeco twist is originally from Louisiana, and Sullivan bubbled with excitement as she described it to me. It has great fall colorsoh my gosh, it is fluorescent everything, all at the same time. Its purple and its red and its yellow and its orange. I mean, it is amazing; its a beautiful tree! She predicts that hers could survive another 50 to 90 years, well into maturity.

Sullivans sheer joy at her zydeco twist points to another reason cities need trees: They lift the human spirit. Trees dont just keep the city cool and the air clean. They also have powerful aesthetic and psychological effects.

You can see it even in the numbers. People are more likely to walk down tree-laden streets, and they pay a premium of 6 to 9 percent for homes in neighborhoods with good tree cover. Sick people do better when surrounded by trees, too: One study found that patients recovering from surgery spent 8.5 percent less time in the hospital when they had a view of nature, compared with those who didnt. Other research found that children with ADHD displayed better concentration after a 20-minute walk in a green park. Trees even appear, remarkably, to correlate with lower rates of crime: Academic research in 2001 discovered that apartments with abundant greenery experienced 52 percent less crime than those with less foliage.

Exactly why trees have such a powerful effect on us is not clear, though in the 1980s, the biologist Edward O. Wilson advanced the concept of biophilia, an innately emotional affiliation of human beings to other living organisms. Weve co-evolved with trees, so maybe we have an emotional bond with them. Some scientists note that trees have self-replicating fractal patternsthe structure of a leaf resembles the structure of an entire treewhich may tickle human brains in ways that few other urban objects do.

You start seeing, through biophilia, what the dappled shade does, says Janette Monear, the head of the Texas Trees Foundation, a nonprofit that supports urban forestry in the state. Your reptilian brain really connects to nature.

Read: Trees that have lived for millennia are suddenly dying

I remember noticing this effect myself after Hurricane Sandy swept through Brooklyn, where I live, in 2012. It destroyed 319 trees in Prospect Park, a huge, 585-acre green space where some 30,000 trees grow. Of those trees that were killed, almost 50 were very maturemore than 150 years old, planted when the park was constructed in the 19th century. When I wandered through the park two days after the hurricane, local residents were standing in little clusters around the huge, toppled elms and oaks, and I saw a few people weeping. I feel like someone has died, one cleanup volunteer told the local radio station WNYC.

Sandy was a big wake-up call to us to make sure that were considering planting trees that are going to be climate-adapted, New Yorks Nav Strauss told me. Kristen King, a colleague of Strausss, is the citys director of natural-areas restoration and management, in charge of planting and maintaining New Yorks parkland, which has about 2 million trees. King and Strauss know that climate change means more superstorms like Sandy. Theyre easing back on planting trees that wont thrive in the hotter, wilder weather to come, such as sugar maple (they need that cold, Strauss says) and northern red oak.

Increasing the diversity of trees is also crucial, King told me. In previous decades, the city had a fairly small range of trees, with only 40 different species. Now King oversees parks and forests with 180 species.

If you have diversity, you have some built-in resilience, she says. If you lose one species, you dont lose them all. This is arguably what got cities in such trouble when they overplanted the ash in the 20th century, only to be sideswiped by the ash borer decades later. Our work in forest management is to fight against monoculture, King says.

Trees dont show you your results right away, as Rob Davis told me. You can build a new building, you can put new sod in, you can build new roadsbut no matter how much money and power somebody has, they cant put back 50-year-old trees.

Davis, back when I spoke with him two years ago, was a forester for Denver, and he was making a crucial point about urban trees: They are the acme of civic planning. You want a street lined with mature, 50-year trees with tons of shade? Great! Even if you find the money and space to plant them, you need to wait half a century to see the fruits of your labor. Odds are youll be dead by then. This means that urban trees require serious forethought; theyre the opposite of whats-in-it-for-me-right-now transactional politics.

The White House has abandoned serious climate planning, and federal climate legislation has also flagged. But some state and local governments have enacted effective climate action. Cities are more responsive, because theyre closer to where early climate problems are already being feltincluding flooding coastal towns and sweltering inland ones. And city councils are a lot more accessible to activists too. When it comes to the urban canopy, everyday citizens have led the way: Some cities created an urban-forestry department after being urged by local nonprofit groups that had spent years doing volunteer work to aid green spaces; in others, urban-forestry departments rely on volunteer labor, such as citizen pruners (permitted to clear dead or hanging branches as they wander the town) and residents who walk around with clipboards doing tree censuses.

Thus far, Denvers trees have survived the temperature increase of the 20th and early 21st centuries pretty well. Davis has seen pictures taken in the late 1800s showing American elm trees that still stand today. But Denver is now heating up in ways that longtime locals can notice too. Ive lived in Colorado all my life, and we used to play ice hockey on ponds here, he noted. Good luck playing ice hockey on a pond here anymore.

Sara Davis, who worked as Denvers urban-forestry program manager when I interviewed her in 2018 (shes currently the city forester for Carmel-by-the-Sea, California), agreed. Were getting heavy, wet snow at the wrong time, she said. It was a couple of years ago that we had a huge storm on Mothers Day. Everything was in leaf, and it washow many inches of wet snow? Eight inches?

So they, too, are focusing on trees that might survive the hotter, spottier weather in decades to come. Kentucky coffeetreeswith pointed oval leaves that cast a mountain of shadewill thrive, they suspect, because they handle drought easily and dont seem much bothered yet by invasive species.

It might also be that, when it comes to trees, our urban future will borrow from our truly ancient past.

I asked Jenny Willoughby, the sustainability manager for Frederick, Maryland, how the citys trees would fare in the hotter decades to come. She worried that one loser would be the sugar maple.

Were getting out of their range, she said. Her phrasing reminded me that the language of cities and climate change can be odd. When you speak of a city going out of range for a tree, it makes it sound like the city is the thing thats movingas if it were an unmoored ship, floating away, pushed along by the tides of climate. Willoughby is also concerned about the fate of the eastern white pine, and the chestnut oak, which is already showing signs of distress.

When I asked her what trees might thrive, she brightened: Ginkgo! The ginkgo tree, as she noted, has a strange history. More than 200 million years ago, it was native to the landmass that became North America, back when the Earth was composed of one supercontinent, Pangaea. When continental drift broke Pangaea apart, the ginkgo vanished from North America. It thrived in Asia, though, where it became a common, hardy tree with large, fan-shaped leaves, and one famous for longevityJapan and China have ginkgo trees that are more than 1,000 years old.

In 1784, William Hamilton, a wealthy botanical collector in Philadelphia, brought ginkgo trees back to the United States to plant on his property. The architect Frank Lloyd Wright loved them, and partly because of Wrights influence, the ginkgo spread into cities across the country. Its still an extremely hardy tree; two of those Hamilton originally planted were alive two centuries later. After hundreds of millions of years, the ginkgo had finally come back to America.

Its technically native, Willoughby noted, so it thrives almost anywhere in the United States. But it doesnt have any species that attack it, nor any that it attacks and crowds out, which makes it a useful addition to a citys forests. Its a really weird conundrum. Ecologically, it exists outside of the whole webits a living fossil. It really hasnt changed over the years. And it really can survive cold and heat, and seems to be happy wherever you put it. One of the trees that helps cities survive climate change may well be one that survived the dinosaurs.

Read more here:
City Trees Need to Be Future-Proofed - The Atlantic

BioAge Plans Phase 2 Clinical trial in Hospitalized COVID-19 Patients

Clinical development plan supported by potent inhibition of PGD2 DP1 Receptor by BGE-175, activating immune-modulating mechanisms that result in 100% survival in aged preclinical models of coronavirus

BioAges proprietary human aging data links activation of PGD2 DP1 signaling to increased risk of mortality and susceptibility to infections

RICHMOND, Calif., Aug. 25, 2020 (GLOBE NEWSWIRE) -- BioAge Labs, Inc., a biotechnology company developing medicines to treat aging and age-related diseases, today announced that it has in-licensed a clinical-stage therapy with significant promise and potential in treating immune aging in older patients hospitalized with COVID-19. The compound, BGE-175, is a potent orally administered inhibitor of the prostaglandin D2 (PGD2) DP1 signaling pathway associated with increased risk of mortality, and susceptibility to infections. The company recently generated preclinical data showing significant immune-modulating and anti-viral activity of BGE-175 which resulted in 100 percent survival in a preclinical model of the SARS 1 virus. In addition to fully protecting infected mice from death and improving morbidity, treated mice showed a 10-fold decrease in virus in their lungs. BGE-175 has demonstrated clinical activity and safety in a large number of subjects across multiple clinical trials for another indication.

Aging is the largest risk factor for COVID-19 morbidity and mortality, said Kristen Fortney, Ph.D., BioAges Chief Executive Officer. BGE-175 has the potential to restore the function of several key immune mechanisms that become dysregulated with aging, and that are critical to mount an effective response to major immune challenges such as COVID-19, SARS, and pandemic influenza. We plan to advance BGE-175 into a Phase 2 clinical trial in COVID-19 patients to evaluate whether its unique mechanism can improve patient outcomes by directly targeting immune aging.

Dr. Fortney added, Our AI-driven analysis of our proprietary human aging data maps out how the immune system is dysregulated during aging. Beyond COVID-19, BGE-175 has the potential to address other diseases driven by immune aging. BGE-175 is the second in a growing pipeline of promising therapeutics that BioAge will bring forward to treat diseases of aging.

BioAges preclinical data, obtained in collaboration with coronavirus expert Stanley Perlman, M.D., an American Academy of Microbiology fellow, and professor at the University of Iowa, shows that DP1 receptor antagonism elicits a potent protective response in a mouse model of SARS-coronavirus viral challenge.

Dr. Perlman noted, We have found over the past several years thatan age-dependent increase inDP1 signaling contributes to worse outcomes in the context of mouse infection with several human pathogens.We havepreviously shownimproved outcomes when DP1 signaling is genetically blocked, but BGE-175 is the first drug that has the same effect.BGE-175 may help counteract deleterious immune changes that occur with aging.

These preclinical data are particularly impressive and highly differentiating to support the potential of BGE-175 in COVID-19, said Adolfo Garcia-Sastre, Ph.D., Professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at The Icahn School of Medicine at Mount Sinai in New York City. While others in the field have used cellular models, BioAges preclinical data in a coronavirus preclinical model may offer more predictive translation of potential in clinical trials.

The pathways impacted by BGE-175 are linked to lifespan and healthspan in BioAges proprietary human aging data. The prostaglandin pathway, as well as several key components of the immune response to viral challenge, are significantly associated with longevity and multiple functional measures. Inhibition of PGD2 DP1 receptor signaling impacts multiple immune mechanisms, including activation of dendritic cells and NK cells, and reducing neutrophil infiltration. Preclinical studies demonstrate that BGE-175 inhibits neutrophil migration and that DP1 inhibition boosts dendritic cell function, both of which counteract known aspects of immune aging, and are also therapeutically promising for COVID-19 and other respiratory infections.

BGE-175 has demonstrated clear target engagement with inhibition of PGD2 signaling and safety in a large number of subjects across multiple clinical trials in another indication. Based on its groundbreaking research on the potential of BGE-175 for COVID-19, BioAge was granted a binding Letter of Intent from an undisclosed pharmaceutical company to enter into an exclusive license agreement to develop and commercialize BGE-175 for treatment and prevention of COVID-19 infections in the United States, Europe and the United Kingdom. Furthermore, for a one-year period BioAge has the exclusive option to license additional rights for other disease indications. Under the terms of the LOI, BioAge will make an upfront payment and contingent development and regulatory milestone payments plus royalties based on annual net sales. BioAge will be responsible for all development, manufacturing and commercialization of BGE-175 for treatment or prevention of COVID-19 infection in the United States, Europe and UK. Further details of the agreement will be released after additional patents applications are filed.

About the BioAge Platform The BioAge platform identifies key drug targets that will impact aging. The Companys proprietary human aging cohorts have blood samples collected up to 45 years ago, with participant -omics data that is tied to extensive medical follow-up records including detailed future healthspan, lifespan and disease outcomes. BioAge has built a systems biology and AI platform that leverages these rich datasets to identify the molecular drivers of age-related pathology. BioAges pipeline of therapies targeting these key pathways will address the significant unmet medical needs of an aging population.

About BioAgeBioAge is a biotechnology company developing proprietary drugs to treat aging and aging-related diseases. Since its founding in 2015, the Company has raised $37 million in venture capital funding from Andreessen Horowitz, Khosla Ventures, Felicis Ventures and others to back its AI-driven approach to map the molecular pathways that impact human longevity. BioAges mission is to develop a pipeline of therapeutic assets that increase healthspan and lifespan.

Source: BioAge Labs, Inc.

Contact Information:BioAge | peng@bioagelabs.comMedia | swheeler@wheelhouselsa.com

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BioAge Discovers Key Pathway and Identifies Promising Phase 2 Ready Drug to Treat and Reverse Immune Aging, a Root Cause of COVID-19 Morbidity and...

The Longevity and Anti senescence Therapy Market Research Report published by Prophecy Market Insights is an all-inclusive business research study on the current state of the industry which analyzes innovative strategies for business growth and describes significant factors such as top developers/manufacturers, production value, key regions, and growth rate. Impact of Covid-19 pandemic on the market will be completely analyzed in this report and it will also quantify the impact of this pandemic on the market.

The research study encompasses an evaluation of the market, including growth rate, current scenario, and volume inflation prospects, based on DROT and Porters Five Forces analyses. The market study pitches light on the various factors that are projected to impact the overall market dynamics of the Longevity and Anti senescence Therapy market over the forecast period (2019-2029).

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The survey report includes a vast investigation of the geographical scene of the Longevity and Anti senescence Therapy market, which is manifestly arranged into the localities. The report provides an analysis of regional market players operating in the specific market and outcomes related to the target market for more than 20 countries.

Australia, New Zealand, Rest of Asia-Pacific

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The research report also focuses on global major leading industry players of Longevity and Anti senescence Therapy market report providing information such as company profiles, product picture and specification, R&D developments, distribution & production capacity, distribution channels, price, cost, revenue and contact information. The research report examines, legal policies, and competitive analysis between the leading and emerging and upcoming market trends.

Longevity and Anti senescence TherapyMarket Key Companies:

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Segmentation Overview:

Global Longevity and Anti-senescence Therapy Market, By Therapy:

Global Longevity and Anti-senescence Therapy Market, By Application:

The report provides an in-depth analysis of the Longevity and Anti senescence Therapy market segments and highlights the latest trending segment and major innovations in the market. In addition to this, it states the impact of these segments on the growth of the market. Apart from key players analysis provoking business-related decisions that are usually backed by prevalent market conditions, we also do substantial analysis of market based on COVID-19 impact, detailed analysis on economic, health and financial structure.

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Longevity and Anti senescence Therapy Market Size The Daily Chronicle - The Daily Chronicle

The report on the Global Cellular Reprogramming Tools Market has been prepared after conducting a comprehensive research through a systematized methodology. These skills are useful for scrutinizing the market on the terms of outlined research guidelines. Mainly, global Cellular Reprogramming Tools market research report covers all the information about the target audience, manufactures, vendors, research papers, products and many more. Keeping a focus on the overall market aspects, and perceptions, this report vastly covers profiles of the companies who have made it big in this particular field along with their sales data and other data. It also suggests the business models, innovations, growth and every information about the big manufacturers that will be present the future market estimates. Every market consists of set of manufacturers, vendors and consumers that gives a definition to the market, its each and every move, achievements. All these are the important subjects required to study the analysis of the global Cellular Reprogramming Tools market.

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Adult Stem CellsHuman Embryonic Stem CellsInduced Pluripotent Stem CellsOther

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Hepatocytes in the liver can naturally regenerate, provided the organ is completely healthy. But when the liver is diseased, it has too much scar tissue to nurture the environment hepatocytes need to replenish themselves.

In a new study published in Liver Transplantation, researchers led by the University of Pittsburgh School of Medicine demonstrated that pigs can grow functioning livers in their abdominal lymph nodes after their own hepatocytes are isolated and injected into them. A startup founded by three of the researchers, LyGenesis, is working to bring the method into human clinical trials.

Senior author Eric Lagasse, Ph.D., associate professor of pathology at Pitt, first demonstrated a decade ago that healthy liver cells injected into the lymph nodes of mice with malfunctioning livers would regenerate and take over normal liver functions. To further prove out the concept, Lagasse wanted to replicate the work in a larger model.

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So Lagasse and his team took pieces of healthy liver tissue from six pigs while at the same time cutting off the main blood supply to the organ. They then injected the cells into abdominal lymph nodes. All six animals were able to regain normal liver functions, they reported.

When they examined the lymph nodes, the researchers discovered a plentiful supply of hepatocytes, along with bile ducts and vasculature that had formed in the transplanted cells.

"It's all about location, location, location," Lagasse said in a statement. "If hepatocytes get in the right spot and there is a need for liver functions, they will form an ectopic liver in the lymph node."

RELATED: Liver-focused Ambys launches with $140M, Takeda partnership

Regenerative approaches to treating liver disease have generated enthusiasm among private investors. In 2018, for example, Third Rock Ventures launched Ambys Medicines, which is developing both cell and gene therapy approaches to regenerating hepatocytes.

LyGenesis, which was founded in 2017, got a major boost in May of the following year when it pulled in $3 million in a series A round from Juvenescence, a U.K.-based fund that has raised $165 million to support longevity-focused companies. In October of last year, Juvenescence and Longevity Vision Fund handed LyGenesis another $4 million in private financing and convertible notes.

LyGenesis is gearing up to start a phase 2a clinical trial of its technique in people with end-stage liver disease later this year.

The new animal study follows previous work by Lagasse and colleagues demonstrating that liver tissue grown in the lymph nodes of pigs with a form of genetic liver disease could treat the condition effectively. The researchers believe the technique could ultimately help people with a wide range of liver-damaging diseases, including hepatitis and alcoholism.

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Functioning liver cells regenerate in pig lymph nodes, and a human trial is coming - FierceBiotech

These days its easy to feel frazzled and distracted. You may be multi-tasking and not getting enough sleep. Maybe youre anxious. And youre probably not doing enough to help your brain work efficiently. If you want to remain sharp and clear-headed as you age, taking care of your brain should be top of mind, says functional medicine expert Bryce Wylde, author of the newly released book Brainspanners.

Accumulation of toxins is associated with cognitive decline, which makes detoxifying essential.

While the brain is designed to detoxify itself, over time this process may become less efficient. Your brain may also be overwhelmed by the sheer amount of toxins its exposed to from the environment and your diet. Thankfully, there are ways you can support your brains detoxification process, says Wylde. And doing so may increase your Brainspan.

Your lifespan is the number of years youll spend on this planet. Healthspan is the number of years you will live in good health. Brainspan, explains Wylde, is the number of years you will live in good health with the healthiest brain possible.

You probably know how much you weigh, and possibly your cholesterol levels and blood pressure. But Wylde says, most people dont know what their brain is doing. We dont give our brain the attention it deserves. Yet it controls the heart, gut and every organ in the body. We arent taught a lot about how to make it healthier.

Wylde says that some of the more efficient ways to support your brains detox process include: M

While many people only think of folate as a necessary nutrient during pregnancy, it is very active in the brain and central nervous system. It also aids in cellular detoxification. Vitamin B9 is found in many fortified foods, as well as fresh fruits and vegetables including nuts and leafy green vegetables.

Glutathione is the most important detoxification molecule, essential for getting rid of harmful chemicals and metabolic byproducts that are dangerous to the human brain. The body makes glutathione but depending on our genetics, some of us are more efficient than others at making it.

Also, our ability to manufacture glutathione declines with age. Others cant get into the cells. Research has shown that a new compound called Glyteine, now available over the counter as Continual-G, raises the cellular levels of glutathione rapidly, within an hour or two.

Our brains do most of their detoxifying when were in deep, non-REM sleep. Thats when the spaces between the brains cells enlarge, and accumulated waste can be flushed away. This cant happen during waking hours. It would be like a railway crew trying to repair tracks while the trains are running.

Wylde explains that toxins lurk everywhere. These include bleach in the laundry room and chemicals in foods and cosmetics. Youve got to pee, poop, sweat, or breathe out these toxins. When your output is less than your input, your brains health may be compromised.

We spoke to Bryce Wylde about how doing something for your brain, every day, is the best thing you can do to ensure its longevity.

Read more here:
What are you doing to increase your Brainspan? - Longevity LIVE

While there's a genetic component to telomere length and durability, there seem to be a few things we can do to help support our own telomeres. Steven Gundry, M.D., heart surgeon and bestselling author of The Longevity Paradox: How To Die Young at a Ripe Old Age, shared an easy one when he appeared on the mindbodygreen podcast: Make sure you're getting enough vitamin D.

"Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob, referring to research in the Archives of Medical Science and the Journal of Nutrition on the association between telomere length and vitamin D levels.

It seems that vitamin D, a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase, the building blocks of telomeres that protect cellular DNA from aging. Gundry goes so far as to say that he thinks it's "the greatest hormone that exists."

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What This Cardiologist Wants You To Know About Vitamin D & Longevity - mindbodygreen.com

The report on the Global Adrenomyeloneuropathy Treatment Market has been prepared after conducting a comprehensive research through a systematized methodology. These skills are useful for scrutinizing the market on the terms of outlined research guidelines. Mainly, global Adrenomyeloneuropathy Treatment market research report covers all the information about the target audience, manufactures, vendors, research papers, products and many more. Keeping a focus on the overall market aspects, and perceptions, this report vastly covers profiles of the companies who have made it big in this particular field along with their sales data and other data. It also suggests the business models, innovations, growth and every information about the big manufacturers that will be present the future market estimates. Every market consists of set of manufacturers, vendors and consumers that gives a definition to the market, its each and every move, achievements. All these are the important subjects required to study the analysis of the global Adrenomyeloneuropathy Treatment market.

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I love you. . . when a spouse says it to their husband or wife, its happy words that re-establish over and over again steadfast endearment, affection, loyalty and it rejuvenates that special bond between two people. Three little words you never tire of, regardless of the longevity of your relationship just engaged, newlyweds or 50+ years together hanging in there through thick and thin, hard times and good times when as a couple you saw everything through together. Bills, ailments, illness, worries and lifes challenges, knowing as a team ordained by God, you could take on the world through sickness and health, life and death. That sweet expression of I love you lasts forever and ever and the miles between Heaven and Earth dont change a thing. Love is love and it is precious. And when a parent says it to their son or daughter, regardless of age, and especially if our children temporarily break our heart, those words bring joy, happiness and security. When a child says it to his/her mom or dad again, regardless of age, they are words we never feel are overstated. Love is the greatest gift.

In my case, I truly, absolutely love everybody and I say it a lot! In fact, folks might think I overdo it, but I hope not. When I recently met with a veteran to assign his Dare County Veteran Discount Card and I started to drive away, I said to him, Love ya! and I meant it. It didnt matter to me if I had never seen him before, I was happy to meet him and thank him for his service. After I got home, I thought, Gee, he didnt even know me . . . wonder if he thought I was a little kooky or something! So I texted him to explain that this is me Marsha M. Brown maybe different than a lot of folks for sure, but well-meaning and sincere.

Im sorry and I forgive you offer peace within our soul to know that if we made a mistake, let someone special down or really blew it, we can tell them were sorry and hopefully they can and will forgive us realizing that none of us are perfect. Sometimes we just plain made a mistake, we misunderstood, we truly forgot or we unintentionally stepped out of line. The hope and assurance the disappointment we might have caused will not be held against us makes a world of difference, because the human aspect is plain and simple we goof up sometimes, not because we mean to, not because were mean spirited or selfish and self-centered. And besides, most of the time, when we let someone else down, in retrospect, the act itself hurts us more deeply. Personally, I fall short of the forgiveness of God way too often. I dont study the Word like I should. I dont take as good a care of my body as I should. I say bad words if I step on something that hurts or Im chased by a swarm of wasps trying to get into the truck before I do or if I forget to do something important that bad word slips out as smooth as melted butter and as quick as a duck on a June bug!

Good job! is seldom heard enough in the workplace. Maybe sometimes supervisors or managers think that if they say it too often, the person theyre praising will get a little cocky, overly confident or too sure of themselves so they hold back, but as the voice of experience and for all the close to 40 years I have been a Realtor, I have been privileged to work for a firm on the Outer Banks that I work for today. Years ago, before I went into full times sales, I was a property manager on Hatteras Island Salvo to be exact and my boss, Janice A. Farr, senior vice president of property management at Sun Realty, who doesnt personally care for the title boss, set an example that I have not experienced since.

She offered to help me whenever I needed guidance; she encouraged me to be the best I could be and she praised my work. She wasnt overboard with it with empty words and meaningless compliments, but she fairly and honestly pointed out my good traits as an asset to the company, which kept me wanting to keep on keepin on to make her proud. She was a hero to me in the workplace and beyond and still is. I loved her then and I love her now. To know Janice is to love Janice.

We all need kind words no matter where we work or what we do. We are human after all, and I think God instilled in all of us the ability to lift others up to a higher plane, to help us see our potential, our value, our worthiness as employees, staff and associates and to help us grasp our contribution to making life better for not only ourselves but for others too. Though I am now in real estate sales, the ten years under her direct supervision were ten of the happiest working years of my life. (Note: it was Janice Farrs daddy W. Chris Aydlett Sr.s celebration of life service that I wrote about in Gig Line, The Sanctity of Life.)

Thank you! Two words that express gratitude. A million times . . . I thank you . . . all of you. The first Gig Line I wrote in March 2012 about my sweet Billys coming home from Vietnam. It was the story about how his return, his outlook on life and his maturity as a vet, grew me up! He and I werent dating when he was deployed in 1966, but after his return in March 1968, God brought us together through a tragic event in my life and from that point, he matured and transformed a 17 year old new graduate of Manteo High School into a young woman who suddenly saw life through his eyes. It was then that I learned what sacrifice really meant, what patriotism was really all about and what riches we as Americans have in our veterans. At 17 we were married and it was nothing but the grace and love of God that gave me the honor and privilege of being married to William S. Billy Brown Jr.

What has that got to do with saying thank you to all of you? Ill tell you . . . because when I wrote that first Gig Line, my sweet husband was proud not because it was about him it was because Gig Line brought to the forefront a personal perspective on Vietnam veteran brothers and sisters, some of what they went through and from that time almost eight years ago, I have continued to write about Billy, brotherhood love of our veterans, their sacrifice that unintentionally taking them for granted. Through that, I have been blessed beyond measure.

Thank you to all the veterans who have called, emailed or snail mailed me over these years. My Billy is in Heaven four years now, but Im contacted sometimes by the men and women who read my column who dearly loved their veteran husband, wife, brother or other family member too who is now up there with Billy. Anna, Wendy, Barbara S., Cathy, Therese, Lee B., Barbara L., Liz, Polly, Valerie, Anna, Peggy, Janice and Alline (my Billy was a hunk a hunk of burning love too!) and literally countless others. My one true love inspired me to write Gig Line, a name we created together. Then in reading it, you all touched Billy, which made him happy; then you inspired me to continue to write it and over time, we have become a veteran community all in its own and that my friend has made me very thankful. I am currently in the process of writing a book and I cannot wait until its ready to be out there!

Until next time, you made my Billy proud, which makes you all precious to me. I love you all! Stay healthy, safe and proud of the veteran you love and were loved by and if he or she is no longer with us, thank the good Lord for the time they were. Love the person God created you to be He doesnt mess up! You are special, you are unique and you are the only you there is. Embrace that, okay? Thank you to all our veterans, active duty and military wantabees! And please keep wearing your masks because its helping keep all of us safe!

If you want to talk, or you know a vet or family member who could use some help, please call/text me: 252-202-2058 or email me: giglineheroes@aol.com or for the real expert in the matters of Veteran Affairs, contact our Dare County Veteran Service Officer, Patty OSullivan 252-475-5604 or email her: dcvac@darenc.com Patty is very diligent about follow up phone calls, so if you call and she doesnt answer, please leave a detailed message with your name, phone number and if you would like, the reason for your call she will call you back and she will do everything she can to help you, I promise! Love yall and please stay tuned!

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Gig Line: A few words that can change the world - The Coastland Times - The Coastland Times