Category Archives: Human Longevity

Latest published market study on Global AI Medicine Software Market with + data Tables, Pie Chart, high level qualitative chapters & Graphs is available now to provide complete assessment of the AI Medicine Software Market highlighting evolving trends, Measures taken up by players, current-to-future scenario analysis and growth factors validated with Viewpoints extracted via Industry experts and Consultants. The study breaks AI Medicine Software market by revenue and volume (wherever applicable) and price history to estimates size and trend analysis and identifying gaps and opportunities.

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Global AI Medicine Software Market Covering Prime Factors and Competitive Outlook till 2026 - Northwest Diamond Notes

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Andy Extances essay provides interesting fodder for thought but what is not discussed is the hysteria (initially over the availability for use then over the potential side effects), (vaccine) hesitancy (predominately over the relatively new technology which has never been used in large population) and hostility (as a result of the divide between those who are vaccinated and those who are not, and in response to government mandate for compulsory vaccination in gazetted workplace and occupation) during this COVID-19 pandemic.

Perhaps the article attempts to focus on scientific aspects of mRNA vaccine development but I would suggest the ink is still not dry yet when considering claims of success of mRNA vaccine based on experience of Pfizer BioNTech (PBNT) and Modernas COVID-19 products.

Of interest, Andy Extance is right to flag the results of Modernas previous foray into mRNA vaccine experience, (ref 1) whereby the 2015 trials of flu mRNA vaccine showed that immunity was short lived.

Remarkably I dont recall any discussion of the longevity of the immunity induced by mRNA vaccine when PBNT was approved for emergency use in the last days of 2020, nor even within the first 6 months of its rollout in the US, UK and EU; perhaps I move amongst the wrong crowd but the first hint of the limits of mRNA immunity in my consciousness only came when the CEO of Pfizer suggested publicly that booster shots may be needed after 6-12 months of the initial shots (ref 2); this is when the US was still trying to get the majority of the population vaccinated, and before reports of increased infection in vaccinated individuals in Israel 6 months after double vaccination (ref 3)

At the time this was attributed to the emerging dominance of the highly infectious delta variant, although it was later found that the vaccines are only slightly less effective to Delta variant compared to the original Alpha type (ref 4).

Hence it was not due to emergence of Delta variant after all (even though this was still being peddled in mainstream media)

Looking at the previous Modernas study in 2015 (published in 2019), this waning immunity 6 months after double vaccination could have been predicted, but was not flagged for some time.

Another important question should be raised regarding mRNA vaccines:The marketing department flogging the advantages of mRNA vaccines suggest the technology made it easy to tweak the mRNA genetic material to address evolving variants of COVID-19 and yet there does not appear to be any new trial to test new subtype of mRNA vaccine to address the apparently new delta variant which was behaving distinctly differently in transmissibility compared to preceding types. Granted the clinical research based on epidemiological data proved the original PBNT was almost just as effective (ref 4) but this data is only available after 5 months worth of data (and status quo in vaccine production).

Was it clinical inertia and more profitable to simply keep producing the same product in the hope that it was just as effective in the meantime? Was it not worthwhile to start testing and making new subtypes of the mRNA vaccine specifically for the delta variant? Were the clauses and restrictions with emergency authorisation for use by the FDA, EMA and MHRA make it too troublesome to have to resubmit new trial data to allow extension to new subtype of mRNA vaccines previously approved under different circumstances (and virus type).

And I havent even commented on the quality issues and stability of mRNA vaccine against COVID-19 and related cold chain logistic issues which is still unresolved.

How about the curious matter of how BioNTech managed to get to the first vaccine to be approved for use in many parts of the world, despite the apparent vast experience of Moderna in mRNA vaccine development prior 2020?

Albeit the fact the PBNT only beat Moderna by just 7 days for emergency use by FDA, there is no doubt that the dominant mRNA vaccine outside the US is PBNT. Granted Pfizer has a far bigger manufacturing capacity than Moderna, setting up a factory to produce mRNA vaccines is not a feat that can happen with a few months.

So many questions that would intrigue historians of the future, some of whom are now eligible for vaccination (ref 7).

Reference1. Feldman RA, Fuhr R, Smolenov I, et al. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials. Vaccine2019;37:3326-34. doi:10.1016/j.vaccine.2019.04.074 pmid:310798492. https://www.abc.net.au/news/2021-04-16/pfizer-boss-says-third-covid-vacc...3. https://www.abc.net.au/news/health/2021-09-09/covid-19-israel-vaccinatio...4. https://www.nejm.org/doi/full/10.1056/nejmoa21088915. https://www.nejm.org/doi/full/10.1056/NEJMoa21142286. https://www.abc.net.au/news/2021-11-26/new-covid-variant-in-south-africa....7. https://www.fda.gov/news-events/press-announcements/fda-authorizes-pfize...

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More questions beyond the hype, hysteria, hesitancy and hostility: the greatest human trial ever (and the natural history of mRNA vaccine use) we had...

Having struggled with an eating disorder myself, there is no doubt that the festive season can be one of the most stressful times of the year. The holiday season is supposed to be a time for relaxation and fun. But, it seems like the whole festive season revolves almost entirely around food and eating. When you are already struggling with anxiety around food and eating, it can seem like the worst time of the year. But, though it doesnt necessarily help, you arent alone. In fact, some research suggests that one-third of all holiday stress derives from food-based overindulgence. Below is a combination of research and personal experience which I can only hope will help if you are in a similar position. This isnt medical advice and I still recommend seeing a professional who can help you in the long term and deal with your specific difficulties.Try to stop viewing food as good and bad

For me, this has been one of the most difficult things to do. To be totally honest, I still struggle with it. Seeing food as neutral rather than good or bad means letting go of all those toxic things youve been taught.

Abby Langer R.D. explained in an article for Self that going into the holiday season with the intention of restricting calories and strict plans usually ends in disaster. This all-or-nothing mentality can lead to even more negative feelings around eating and your body. Usually, these super restrictive rules lead to slip-ups. Once youve broken your rules, it can be easy to end up bingeing and ultimately, making yourself feel worse.

As difficult as it is when you begin to see food as neutral and simply eat what you feel like, at the time, it takes a weight off your mind. Ive found that focusing on listening to what my body wants has resulted in me eating less sugary snacks and more healthy foods that are nutritious and, generally good.

Its also important to realize that the low-calorie option isnt always the best option nutrition-wise. Eating a balanced and healthy diet is ultimately going to be better for you. That can include protein, salad, vegetables,and some sweet holiday snacks.

Its easy to get caught up in the holiday spirit and end up buying all the sweets and chocolates available. I have an awful tendency to fall for the pretty packaging and can end up buying things that, without that pretty container, I wouldnt usually buy. Making a list before you go shopping can be hugely beneficial for this and can help you to avoid falling into this trap.

It will also help you to eat better in the time surrounding the holidayswhen youre still cooking for yourself. Maintaining a normal way of eating as much as possible is of huge benefit and can make you feel that youre more in control.

Its also worth saying here that, if you dont have it, you cant eat it. If you are looking to avoid unhealthy snacks and foods, making sure you keep them to a minimum will inevitably help you to avoid them, at least when youre in your own house.

Planning to have healthy snacks on hand can also be of huge benefit to those last-minute invitations. You can bring something from home that you are comfortable eating, which means that youll have a safe option to rely on.

Unfortunately, there seems to be at least one in every family. It might be that random uncle whocomments on your body or weight that you can usually avoid.

Photographee.eu/Shutterstock

However, over the holiday season, you are forced to interact with him. Its definitely not great but, unfortunately, it can be unavoidable. When you are forced into interactions with those types of people, try to set boundaries with them right up front.

For instance, Langer suggests telling them that you wont discuss your body or your diet. She also suggests the thats none of your business angle might work. However, it could also cause issues so what I try to do is stay away from those types of people as much as I possibly can.

Alternatively, if you really cannot manage to avoid them, try to immediately re-direct the conversation when you start to feel triggered. Remember that you always have the right to take some time away from everybody to breathe and regain control of the situation. If you really struggle, try to chat to a friend about being on hand for a text if you need emotional support.

Remember that you are human and that things can affect your emotions differently even on a day-to-day basis. Trying to take some personal time away from people during the holiday season, as I find this can really be helpful in maintaining a more balanced perspective. Taking care of yourself and accepting the way you feel is also hugely helpful when it comes to dealing with food and the holidays.

As much as you can, try to actually enjoy the food itself and become more focused on the enjoyment than the calories or carbs. It can be a difficult time when it comes to food, forgive yourself when you are unable to cope, and really take time to analyze how you feel. Itll likely help you in the future.

https://www.self.com/story/holidays-food-anxiety

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Food Anxiety and The Festive Season - Longevity LIVE - Longevity LIVE

Denise Obrero understood the power of housing stability early in her career and learned a deep respect for elders and seniors from her family and community. The ability to combine those passions in her latest work with Community HousingWorks is an opportunity she welcomes.

The nonprofit organization develops, rehabilitates and operates affordable housing in San Diego County and California, providing programming, resources and services to help residents.

Last month, it was one of a number of local nonprofits awarded grants from The San Diego Foundation for efforts to enhance the quality of life for older San Diegans.

With a $30,000 grant, CHW is launching a yearlong pilot program for seniors 55 and older in their housing communities to work part time in areas that include education-related programs with children, health and wellness programs, and services that include food delivery or financial literacy support for fellow senior residents.

Obrero, 50, is director of programs for the nonprofit and has previously worked as a teacher and in managing public funding to support affordable housing developers. She divides her time between living in Golden Hill with her son, Kai Pele, and their dog, Chivo; and San Clemente to take care of her aging parents. She took some time to talk about the organizations pilot program and how her experiences growing up in Los Angeles in the 1990s, and her previous work in education, have influenced how she approaches her nonprofit work today.

Q: Where did the idea for this kind of program for seniors come from?

A: For some time, weve been discussing how the senior population in San Diego and in CHWs communities is growing rapidly. Weve made some move in terms of our development focus to address this, by building several senior-focused communities in the past few years (including North Park Seniors, which specifically serves the LGBTQ population, along with Mission Cove Seniors in Oceanside, and Windsor Gardens, which is a rehab project in Escondido).

This initiative is really about the programs and services we deliver once these communities are built. All of our programs and services are designed to provide residents with a platform for success, and what that looks like for seniors is the ability to age in a safe, stable and affordable home where they can rely on neighbors and engage in community activities that increase health and wellness.

Q: Why did your organization want to focus on employment, financial independence and decreasing isolation?

A: In conversations about seniors in our society, we hear that they still have a lot to contribute, even in retirement. There is a tremendous amount of leadership and energy that can benefit other generations of residents, while giving seniors a way to stay mentally and physically active. Theres a great deal of data to support that decreasing isolation leads to better health outcomes, which means greater longevity and independence. We saw a need with our after-school programming, which really excels when we have part-time support in helping with the children at each of our sites. This pilot will test whether these two needs can be met with the same initiative, and to see how that might function in terms of providing some additional resources to seniors living on a fixed income, particularly at a time when prices for so many things are rising.

Q: How have your experiences growing up in Los Angeles, and as a teacher in New York and Oakland, influenced the way youve approached your later work in nonprofit organizations?

A: All of my experiences in North America and living abroad have shaped the way that I approach working in high-need communities and raising my son. I am a compassionate, empathetic, tolerant and spiritual human being. The epidemic of gang-related homicides while growing up in L.A. was deeply impactful, and I have seen generational trauma in the communities that I have worked in. Looking back, I would not change one decision because in each of these urban cities, Ive learned a great deal about myself. I lean into taking risks and moving to new areas because I enjoy the challenges that come with not knowing everyone. I have intentionally continued to work in a nonprofit organization because I want to positively influence and move the needle in terms of using housing as a platform for resident success.

I was drawn to Golden Hill because it offers one of San Diegos most historic and architecturally eclectic buildings with many homes from before the 1900s. It is centrally located and close to downtown. It is a vibrant community of cool shops, restaurants and boutiques intermixed with small mom-and-pop businesses that I like to support. The neighborhood is very walkable, and the neighbors are friendly. Golden Hill has the type of vibe and diversity that reminds me of growing up in Los Angeles and parts of the Bay Area.

Q: Whats been challenging about your work?

A: Our current housing crisis is clearly a challenging health issue. We struggle to debunk and fight against the Not in My Backyard attitudes, and we cannot build homes fast enough to meet our current regional housing gaps. Another glaring layer to this is the historical context. When we analyze the federal housing policies in the 1940s and 1950s, there was a deliberate system of oppression targeted at people of color. The federal government created the Federal Housing Association (FHA) in order to spur homeownership. However, the long-term mortgage loan opportunities were only for White homeowners. Redlining occurred in areas like southeastern San Diego, which were earmarked as hazardous. If you are reading my story today and are intrigued to learn more about the history of subsidized housing, racial covenants and their role in housing segregation, please, take the time to read The Color of Law: A Forgotten History of How Our Government Segregated America by Richard Rothstein.

Q: Whats been rewarding about this work?

A: Hearing our senior residents lived experiences and stories. They embody genuine humility, grace and grit. For me, I feel the human connection with people who have the same dreams for their children and grandchildren as I do. Since 1994, I have been working in this vibrant industry. My first career path was teaching in urban cities and when I conducted home visits to my students apartments in communities like West Oakland, I saw firsthand that opportunities began with housing stability. Seeing the smiles and successes from our residents has been the most rewarding part of this work. Knowing that neighbors are consistently caring for each other especially during last years lockdown was truly inspirational.

Q: What is the best advice youve ever received?

A: Doors will close, doors will open in your life and This, too, shall pass. My 78-year-old dads sage advice has helped me to clearly recognize that a negative event or circumstance often leaves room for the beginning of something positive. In 1977, my parents took a big leap of faith and became small business owners in South Central Los Angeles. During the 1992 Los Angeles riots, it felt like the world was closing in on all of us. My parents embodied the resilience that you need to carry on along with the residents. Our community rallied together and collectively became organized and stronger in many ways.

Q: What is one thing people would be surprised to find out about you?

A: People often ask about my nationality. On my fathers side, his mom emigrated from Hermosillo, Mexico, and his dad emigrated from the Philippines. On my mothers side, her parents emigrated from Japan to Los Angeles (via Angel Island). In 1942, my grandparents lost everything they owned when they were forced into the Japanese internment camps. When my grandparents and family returned from the Wyoming relocation center, they helped to create the close-knit neighborhood of Little Tokyo in downtown L.A. There was a strong sense of belonging that provided ongoing support for seniors and residents in need. Because of my multiracial background, I see the world from a multicultural lens. My relatives on both sides of my family have instilled a strong respect for all elders and seniors. Elders offer their life experiences and stories, and bring wisdom that is part of the fabric of our extended family and collective community.

Q: Please describe your ideal San Diego weekend.

A: It starts off with pretty strong coffee and lounging in the backyard garden patio. I would definitely (join) my two close friends from my UC San Diego days to get a body detox spa treatment at Karma Massage in Hillcrest. Afterward, we would find a Korean barbecue or sushi spot to share a leisurely lunch where were typically eating and talking for hours. That evening, I would get my dog and walk along the beach in Del Mar, watching the sunset.

On Sunday morning, I enjoy reading the print version of the paper and going to yoga in the park. My ideal day would be spent listening to podcasts and Common Kings island music, and maybe paddle boarding at the beach. I also enjoy stopping by The Ecology Center in Encinitas and purchasing a farm share fresh produce box for the rest of the week. My weekend would wrap up with barbecuing in the backyard and enjoying time with my aging parents and my son. We always try to plan Sunday dinners together.

See the original post here:
San Diego nonprofit gets grant to help seniors living in its affordable housing communities - The San Diego Union-Tribune

Last December we were still deep in social distancing and isolation.

But here we are a year later, and the holiday season feels a bit more hopeful. Evidence shows that the prospect of being able to gather playsbig role in our enthusiasm for the upcoming holiday season.

Even before the pandemic, many couldn't wait for the holidays. And this year, people are especially excited because we can be together without any major restrictions.

But being apart for such a long time and the new habits we've developed due to social distancing rules means the adjustment to full-on festivities won't be easy for everyone. But, staying isolated isn't good for our well-being either particularly during the holidays when being together in person is a major contributor to our happiness.

According to the Canadian Mental Health Association,connecting with others is more important than most people realize. Social connection can lower anxiety and depression, help us regulate our emotions, and can give us higher self-esteem and increase our empathy.

According to Stanford researcher Emma Seppala, social connection:

Unfortunately, the opposite is also true. Low levels of social connection are associated with:

Major holidays are important for maintaining and growing close connections with family members and research shows people often experience increased wellbeing during these times.

For example, Dec.25is one of the happiest day of the year in Canada, andThanksgiving is one of the happiest days of the year in the United Statesas people claim to have the least stress.

A study that analyzed well-being during Thanksgiving in 2020 found that participants who saw even one other person face-to-face reported significantly higher personal life satisfaction, sense of growth, and wellbeing than those who did not.

The data reinforces that it's connection not gifts or food or decorations that make us happy during the holidays.

However, the holidays can place pressure on people to be happy,even when they aren't.

For some, this time of the year can feel increasingly isolating and stressful. In an era of grief where families have lost loved onesto COVID-19, celebrating can feel particularly hard.

It can also be challenging for seniors. Some may be living alone, or they can't risk being with others because of COVID-19, or travel is too hard on them physically.

This is why we really need to look out for each other and find ways to connect even more this year than ever before.

Eldercare consultant and Minding Our Elders author Carol Bradley Bursackhas several suggestions on how to better connect with our seniors. She suggests:

Most importantly, it's about reinforcing social connections and making sure our most vulnerable know that they matter and are loved.

After 20 months of being apart, it's understandable to struggle with getting out there and being social. The number of people now reporting social anxiety has skyrocketed since the pandemic.

But, it doesn't need to be this way forever. We can break the habit of disconnection to get back to what contributes most to our long-term happiness:social connection. Here are some tips to get back in the habit of hanging out.

Talk Yourself Up. It may sound hokey, but sometimes we need a little internal pep talkto make sure we don't bail at the last minute. We don't need to say yesto every event,but we should commit to one or two that are meaningful. Just plan to follow-through without giving your brain anopt-out clause.

Help the host. Focusing on tasks can help reduce anxiety and as we're handing out food or taking coats or helping out,we get time to normalize to the environment.

Hang out with the littles. According to journalist ReneeFabian, in her article 9 Ways To Manage Social Anxiety During The Holidays she shares that "adults can be anxiety-provoking. But at a family or friend party, there's a good chance there may be children, pets, or both, and they offer an opportunity to take the perceived spotlight off of you."

Fabian writes that pets can also provide mental health benefits during stressful times: "Petting animals reduces blood pressure, elevates mood, and releases endorphins."

Prep talking points. Some suggest if you are feelingextreme social anxiety to use tools like preparing a few talking points or conversation starters.

Leverage a mantra. In your head in moments where you're particularly stressed, repeat, "I'm ok" or"I'm not the only person who feels weird/uncomfortable/awkward.I am not alone."

Phone a friend. Or just plan a signal that has your friend coming to your rescue if you're really struggling in a conversation.

Despite people feeling more nervous than normal to connect with others right now, it's important to try even if it's just for a few hours.

This next month in our lives should be about gathering and reconnecting. We could all use some levity and storytelling while eating and celebrating traditions it's deeply encoded into the traits that makes us human.

And it's why so many of us, despite our stresses and worries and fears, love this season most of all.

More here:
Ways to feel connected this holiday season after months of isolation: Jennifer Moss - CBC.ca

For years, certain foods have been promoted as the key to a long and healthy life, from common vegetables and healthy fats to powders made from exotic plants.

But a number of anti-aging diets focus not on what you should eat, but instead on limiting your intake of food overall or restricting your meals to certain days or times of the day.

These diets include calorie restriction, intermittent fasting, fasting-mimicking diet, the keto diet, and time-restricted feeding.

All of these are intended to not only increase your life, but also extend the number of years youre in good health, known as lifespan and healthspan, respectively.

Much of the research on anti-aging diets has been done in non-human organisms from microbes to worms to rodents.

One reason for this is that its easier to follow the entire lifespan of these creatures, because their lives are so much shorter.

Research in people is also starting to suggest that some dietary patterns may help people live longer and age more gracefully.

However, some researchers caution that data on the benefits of these diets for people is limited especially when it comes to knowing if eating a certain way can extend the human lifespan.

Despite their recent popularization, there is not yet strong evidence that any of the anti-aging diets studied in laboratory animals have substantial long-term health benefits in non-obese humans, wrote Matt Kaeberlein, PhD, and his colleagues in a review in the journal Science.

In the Science paper, Kaeberlein and his colleagues reviewed existing research on anti-aging diets, focusing on studies done in rodents, and whenever possible, people.

In the rodent studies, the most promising anti-aging diets involved calorie restriction.

This included the classic calorie restriction diet, where daily calories are reduced by 20 to 50 percent, and a variation that involves reducing overall calories but maintaining protein intake.

This fits with other research looking at the opposite the impact of greater food intake.

Michael J. Forster, PhD, a researcher at the University of North Texas Health Science Center who studies aging, said research shows that when rodents and non-human primates consume more calories than their body uses, they see a reduction in life expectancy.

The size of this lifespan shortening depends on how much excess food is eaten and for how long, he said.

One could argue from the rodent studies that the difference in life expectancy [between animals] due to caloric intake is up to 50 percent, said Forster.

Another diet that Kaeberlein and his colleagues found promising is intermittent fasting, in which mice fasted for 1 day in between feedings.

However, this is also considered a type of calorie restriction because mice end up consuming fewer calories overall due to the fasting days.

Scientists have studied other diets, as well, but so far, calorie reduction seems to have the biggest impact on the lifespan of rodents and other non-human organisms.

The evidence is poor that any current dietary practice other than [calorie restriction] will significantly and broadly influence health and longevity, said Forster.

In spite of the promising results in rodents, so far no anti-aging diets have been shown to be effective in the clinic, wrote Kaeberlein and his colleagues.

However, there is some evidence consistent with anti-aging effects for [calorie restriction] and related diets in humans, they added.

Valter Longo, PhD, a researcher who studies aging at the University of Southern California Leonard Davis School of Gerontology, said part of the problem with this research is that researchers, scientists, and clinicians often work in isolation.

Whats missing is a multi-disciplinary approach, he said. If you put all [the research] together, you get a very different picture with certain nutritional interventions not only consistently associated with health, but also with longevity.

Because of the challenges of following people for decades, much of the anti-aging diet research focuses on shorter-term benefits.

For example, caloric restriction over a period of 2 years has been found to improve insulin sensitivity and risk factors for cardiovascular disease.

The fasting-mimicking diet has also been found to improve body mass index (BMI), blood glucose levels, blood pressure, and other health markers.

While much of the emphasis of anti-aging diet research is on pushing the boundaries of lifespan and healthspan, Forster thinks researchers should focus more on why some people lose their physical and mental function as they age.

What processes and preventable events contribute to failure to achieve optimal health during aging and make us vulnerable to disease? he said.

Although more research on these diets is needed, from one perspective, we already have significant information, said Forster. Maintaining a healthy weight throughout life tends to maximize health and longevity.

Longo also thinks scientists have enough data on the benefits of less extreme diets to be able to recommend them to certain groups.

For example, while he doesnt think people should do 16 hours of fasting every day for the rest of their lives, a shorter fast period during the day should be safe for most people.

There are no studies that Ive ever seen on 12 hours of fasting and 12 hours of feeding every day being harmful, he said.

For other diets, such as the fasting-mimicking diet which Longo studies, there are more caveats. But not so many that Longo couldnt easily rattle them off in 30 seconds.

Some of his warnings are against doing these diets too often or too extremely or when there are medical reasons for a person to not restrict their diet.

What if you restrict yourself too much or for too long? What if you restrict yourself when youre 85? Well, that could be a big problem, said Longo.

Severe calorie restriction can potentially lead to increased cold sensitivity, decreased sex drive, poor sleep, chronic fatigue, and muscle weakness.

A study by Longo and his colleagues also found that while a low protein diet was beneficial for people ages 50 to 65, those over 65 on this diet had a higher risk of dying.

Other researchers have raised a concern that intermittent fasting and other restrictive diets could lead to disordered eating.

While not everyone who restricts their eating to every other day or within an 8-hour window will go on to develop an eating disorder, some people may have a higher risk.

As for the fasting-mimicking diet, Longo said many people could benefit from doing this 2 or 3 times a year, but not more frequently.

But, he said there are other dietary patterns not related to calorie restriction that are known to be beneficial.

This includes eating a low protein diet (but not too low, especially if youre an older adult), and eating a more plant-based diet, and if youre vegan, ensuring that you get all the macronutrients you need, especially amino acids.

While you have the need for personalization [of the diet], said Longo, there are some things that will benefit the great majority of people.

Original post:
How Effective Are Anti-Aging Diets? Here's What Science Tells Us - Healthline

Antiageing foods: Myths or reality?  |  Photo Credit: iStock Images

"First hint that bodys biological age can be reversed," screamed the headline of Nature.com, an online scientific articles website. In a small trial, drugs seemed to rejuvenate the bodys epigenetic clock, which tracks a persons biological age, it reassured.

According to the report in Nature.com, a small clinical study in California has suggested for the first time that it might be possible to reverse the bodys epigenetic clock, which measures a persons biological age. By testing the blood samples from the said clinical trial designed to reverse aspects of human ageing, scientists found a significant reversal in their epigenetic ages.

What was the experiment?

Thymus Gland on the radar:According to the report in Nature.com, the results were a surprise even to the trial organisers but researchers caution that the findings are preliminary because the trial was small and did not include a control arm.

Id expected to see slowing down of the clock, but not a reversal, says geneticist Steve Horvath at the University of California, Los Angeles, who conducted the epigenetic analysis. That felt kind of futuristic. The findings were published on 5 September in Aging Cell.

It may be that there is an effect, says cell biologist Wolfgang Wagner at the University of Aachen in Germany. But the results are not rock-solid because the study is very small and not well controlled.

The latest trial was designed mainly to test whether growth hormone could be used safely in humans to restore tissue in the thymus gland. The gland, which is in the chest between the lungs and the breastbone, is crucial for efficient immune function.

What the Thymus Gland does:White blood cells are produced in the bone marrow and then mature inside the thymus, where they become specialized T cells that help the body fight infections and cancers. In simple words, a type of lymphocyte that develops in the thymus gland, T-cells are essential to human immunity. As we age the thymus gland starts to shrink after puberty and increasingly becomes clogged with fat.

The epigenetic clock is an age predictor based on DNA methylation levels. It is dependent on the bodys epigenome, which is a complete description of all the chemical modificationssuch as methyl groupsthat tag DNA and histone proteins.

The pattern of these tags changes throughout the course of a persons life, and tracks their biological age, which does not necessarily coincide with their chronological age.

According to the researchers, additional studies need to be done on immunosenescence.

Evidence from animal and some human studies shows that growth hormone stimulates regeneration of the thymus. But this hormone can also promote diabetes, so the trial included two widely used anti-diabetic drugs, dehydroepiandrosterone (DHEA) and metformin, in the treatment cocktail.

Foods that boost the functions of the Thymus gland and Immunity:

What "not to do" or what to "give up" to age healthier?Ageing is inevitable. But take the dullness, stress, ill-health, and regret out of the process. Go easy on sugar if you cannot give up the artificial option altogether. Sugar can actually depress immune activity, so avoid any forms of it if you are fighting an infection. Give up smoking. That is in fact, enemy number one of a long healthy life. Longevity does not sit fine on the cancer stick, sorry! People around the world are changing the rules of ageing. Some simple changes in your lifestyle will help you age gracefully. Why not do it?

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

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5 foods that have anti-ageing longevity-promoting properties; boost immunity, reverse ageing and help live long healthy life - Times Now

The debate of greatest of all time between Michael Jordan and LeBron James is never-ending, but the Lakers star keeps getting his flowers from the players currently in the league.

For the past 10-15 years, LeBron James has been the face of the NBA, and for many the GOAT. The four-time Finals MVP is a generational superstar. Though he has a section of haters, one cannot deny his impact on the game.

Since the day he debuted in the Cleveland Cavaliers uniform for the first time in 2003, theres never been a player in the NBA who has performed at the top for 19-years. But is he the GOAT?

Also read: Lakers superstar shows off a few celebrations as he leads the team past the Pacers in a OT 124-116 win

Every time a GOAT conversation comes up, Michael Jordan stays a constant parameter. But if one talks about longevity and giving their everything to the game, no one comes close to LeBron. Even MJ, the 6-time NBA Champion got bored of the game and tried Baseball, while already struggling with a gambling issue.

James never had such issues, hes the perfect role model for any up-and-coming athletes to structure their career path around. In his year nineteen, the King is a force to reckon with, no matter where he plays. And is now playing with players who as kids, watched him destroying several NBA legends since he debuted in 2003.

LeBron James made it to 8-straight finals since 2011 when he went to the Miami Heat. Only the Boston Celtics and 3 players of that team have more. The 4-time NBA champion has played most Playoffs games in NBA history and also has thebest winning percentage. Then hes third in the all-time scoring list and might finish at the top when its all said and done.

What separates him from others in the GOAT conversation is his understanding of the game and playmaking abilities. The point-forward is top-10 in all-time assists as well.

Those are just the records speaking for the King, in his 19th year in the league. Nobody has been as consistent as him for this long. The 17-time All-Star is still the MVP in his team ahead of two future Hall of Famers and NBAs top-75 players of all time. His longevity coupled with the level of production he is still showing is unmatched.

After winning his 4th title with his third franchise, for the last two seasons, he has shown signs of being a human who can have injuries. The Lakers projected to be the best team in the West at the start of this season, would clearly not make it to the Playoffs if their 36-year old MVP misses more games due to nagging injuries.

After their win over the Indiana Pacers Wednesday night, on the back of a LeBron James show, Lakers shooting guard Malik Monk described the 4-time MVP to be his and his generations GOAT.

With the form they are in, the Lakers might face a tough time to finish as a top-4 team in the West, but where ever they do end up, LeBron James and Co will be a team to avoid in a 7-game series.

The way few teams were trying to avoid the them in the last seasons Playoffs when the Lakers were struggling to even make it there, with an injury-plagued squad, solidifies Brons significance as an undisputed king of the league at this age.

Also read: LeBron James anger deemed righteous by Pacers fan after Lakers superstar got hecklers ejected

If James somehow wins another title, he will surely be head to head with Michael Jordan to be the GOAT just because of his longevity and unmatched basketball IQ.

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"LeBron James is the Michael Jordan of my generation": Lakers teammate Malik Monk heaps praises of the King... - The Sportsrush

Personnel Operations

The personnel operations section of this division processes all personnel actions. In fiscal year 2019, more than 3,673 separate actions were processed manually, including appointments, separations, leaves without pay, three and six-month probationary paperwork, and longevity bonuses, preparing and distributing salary adjustment invoices, as well as, other miscellaneous actions such as tax, address, and name changes. The operations section maintains all employee personnel records and position control for the judicial branch of government, using an automated information system and periodic reports. This section also audits all Unified Judicial System payrolls and certifies state service for the annual longevity bonus and conducts background checks and E-verify for applicants for the pre-employment screening process.

The payroll section of the Human Resources Division provides or processes services such as: daily data entry, timesheets, one-time pay, supplemental pay, circuit clerks restitution, reimbursement checks, Title IV-D payments, duplicate/cancelled warrants, county supplement, FICA cut offs, W-2 and eMap service requests through the year, JPO fund updates, insurance, reimbursement for separated/terminated/retired employees, longevity bonuses, deferred compensation (e.g., Great-West, RSA-1, United Way) funding source/organization code changes, unemployment compensation, insurance billing, direct deposits, employment verifications, retirement contributions, and miscellaneous deduction.

The Human Resources Division is responsible for monitoring a leave program (Human Resources Desktop) for approximately 1,500 leave-earning UJS employees. Because leave represents a potential debt of the UJS, the Human Resources Division audits leave accounts annually. In fiscal year 2019, the Unified Judicial Systems total leave liability exceeded $863,334.60 and separation costs exceeded $936.757.00.

For fiscal year 2019, approximately 450 applicants took the written court specialist examinations that were given in the State of Alabama. In addition to maintaining the open and promotional court specialist registers, the division issued numerous special job announcements for positions at the AOC, the trial courts, the appellate courts, and the State Law Library. Approximately 800 total applications were received from these announcements.

As of December 2019, there were 487 minorities employed in the UJS. This included 67 elected officials. Minorities comprised 24.45 percent of the total Unified Judicial System work force. The Human Resources Director is also the EEOC Officer for the UJS.

Image courtesy of Ambro at FreeDigitalPhotos.net

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State of Alabama AOC: Human Resources Division

Demographers predict that as many as half of the children born in the developed world since 2000 will reach the age of 100 and beyond. Once a rare event, century-long lives will become commonplace by 2050. The near doubling of life expectancy presents a range of challenges along with yet unrealized opportunities.

To the extent that we continue to live our lives according to the norms, institutions and policies based on lives half as long as the ones we now enjoy, we will surely face a crisis. However, if we act quickly to apply scientific and technological solutions and change the ways we live, theadded yearscan improve quality of life atallages.

In 2018, the Stanford Center on Longevity launched an initiative we callThe New Map of Life, premised on the belief that this profound transformation in human longevity calls for equally momentous and creative changes in the ways we lead 100-year lives. Building on the work of Stanford Center on Longevity research fellows, who analyzed central life domains affecting long life outcomes, we argue that if we act now, we can not only meet the challenges longer lives present, but we can also use added years to improve quality of life at all ages. We have distilled this work into a set of crosscutting principles that can act as guideposts for The New Map of Life.

We must first recognize that the unprecedented age diversity in society today is a net positive.The speed, strength and zest for discovery common in younger people, combined with the emotional intelligence, prosocial tendencies and wisdom prevalent among older people, create new possibilities for families, communities and workplaces that havent existed before.

Rather than dwelling so anxiously on the costs incurred by an aging society, we can instead measure and reap the remarkable dividends of our increasingly age-diverse world.

The process begins by investing in todays children the futurecentenariansof the 21stcentury. Early childhood investments deliver big returns, as benefits can compound for decades, while allowing for more time to recover from disadvantages and setbacks.

The pivotal years between birth and kindergarten are an optimal time for children to acquire many of the cognitive, emotional and social skills needed for a healthy, happy and active life. Beyond childhood, we must invest in public health ateverylife stage.

Also see: 90% of people want to grow old in their own home whats the real cost of doing so?

Rather than lifespan, we should makehealth span the years when people are healthy, mobile, mentally sharp and free of pain the new metric for determining how, when and where to allocate our resources.

To ensure that all people reap these benefits, we should invest not only in better access to health care, but in the health of communities, especially those affected by poverty, discrimination and environmental damage.

Read: The best ways to save for retirement at every age

Over the course of 100-year lives, we may work 60 years or more. But we should not work the way we do now, cramming 40-hour weeks into lives impossibly packed from morning until night with parenting, family, caregiving, schooling and other obligations.

Workers seek flexibility, whether that means working from home at times or having flexible routes in and out of the workplace, including paid and unpaid intervals for caregiving, health needs, lifelong learning and other transitions to be expected over century-long lives.

As we move in and out of careers and life roles, we will need to also buildflexibility into how we learn. Rather than front-loading formal education into the first two decades of life, The New Map of Life envisions new options for learning outside the confines of formal education, with people of all ages able to acquire the knowledge they need at each stage of their lives and to access it in ways that fit their needs, interests, abilities, schedules and budgets.

We cannot ignore the impact of the physical world around us. The impacts of the physical environment begin before birth, with advantages and disadvantages accumulating over the entire course of life, determining how likely an individual is to be physically active, whether they are isolated or socially engaged, and how likely they are to develop obesity, respiratory, cardiovascular or neurodegenerative disease.

Currently, individual life expectancies in the U.S. can vary by as much as 20 years, depending on where a person is born and raised. We must start now to design and build neighborhoods that are longevity-ready, and to assess potential investments through a lens of long life, considering not only current quality of life, but the impact of our homes and communities on our future selves.

Finally, we must all be prepared to be amazed by the future of aging!

Todays children will grow up in tomorrows world. Medical advances will lead to treatments both more effective and more personalized than what we currently experience. Progress in artificial intelligence, ubiquitous high-speed connectivity, materials and manufacturing hold the promise of redesigning a more flexible and equitable world.

And while there is currently no way to stop the process of aging, the emerging field ofgeroscienceholds the potential to transformhowwe age, by seeking to identify and reprogram the genetic and molecular mechanisms behind aging at a cellular level. Such interventions would simultaneously reduce the risk of the host of diseases and degenerative conditions for which age is the dominant risk factor.

Meeting the challenges of longevity is not the sole responsibility of government, employers, health care providers or insurance companies. It is an all-hands, all-sector undertaking, requiring the best ideas from the private sector, government, medicine, academia and philanthropy.

Read next: This couple retired 2 years ago on about $27,000 a year. Heres how thats going

It is not enough to reimagine or rethink society to become longevity-ready; we must build it, and fast. The policies and investments we undertake today will determine how the current young become the future old and whether we make the most of the 30 extra years of life that have been handed to us.

Laura Carstensenis the director of the Stanford Center on Longevity and professor of psychology and Fairleigh S. Dickinson professor in public policy at Stanford University.

This article is reprinted by permission fromNextAvenue.org, 2021 Twin Cities Public Television, Inc. All rights reserved.

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