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Category Archives: Human Longevity

Covid-19, flu combo vaccines an advance but with distribution quandaries – Clinical Trials Arena

Posted: March 15, 2022 at 6:17 am

Need to know:

Moderna and Novavaxs Covid-19 and influenza combination vaccine draws expert enthusiasm for efficacy owing to the formers mRNA vaccine technology and the latters noninferior data for its standalone protein subunit flu vaccine. They were less enthusiastic about Moderna and Pfizer/BioNTechs investigation for variant-specific or multivariant Covid-19 vaccines, noting nebulous commercial or practical value despite the studies having scientific importance.

Regarding the Covid-19/flu vaccines, the assets featuring two antigens should not interfere with each others efficacy when combined, and their side-effect profiles should be similar to standalone versions. The one notable caveat with this approach is that while flu has a predictable annual seasonality, the same cannot be said so far with Covid-19, which can make it tricky to pinpoint ideal distribution timelines for the combo. Novavaxs Phase I/II combo vaccine study (NCT04961541) has data expected in April, while Moderna is still in preclinical stage.

As for variant-specific or multivariant Covid-19 mRNA vaccines, the lack of expert enthusiasm is due to data from the current crop of vaccines showing they are still efficacious against recent variants of concern. Also, by the time a vaccine is tweaked to feature the most recent variant, there is the risk that the variant would no longer be prevalent in the community. Nonetheless, there is scientific rationale to these studies to demonstrate existing vaccine technologies can be adapted for future variants.

Modernas variant-specific vaccines are targeting Beta, Delta, or Omicron and the multivariant shot zeroing in on both Beta and Delta in a Phase II/III trial (NCT04927065). Pfizer/BioNTech are targeting Alpha/Delta in Phase II (NCT05004181). The Pfizer/BioNTech trial is estimated to end in April, while Modernas trial conclusion is expected March 2023.

A Covid-19/flu vaccine is attractive as it combines two preventive approaches into one, says Dr William Schaffner, an infectious diseases professor at Vanderbilt University. The combo can reduce vaccine hesitancy and ease the publics fatigue towards vaccinations, explains Rodney Rhode, PhD, chair and professor, Clinical Laboratory Science Program at Texas State University.

Novavaxs protein subunit combo vaccine features its yet-to-be US-authorised Covid-19 vaccine Nuvaxovid and its Phase III seasonal flu vaccine NanoFlu. Meanwhile, Modernas combo vaccine features its FDA-approved Covid-19 vaccine Spikevax and its seasonal flu vaccine mRNA-1010, with the latter standalone vaccines furthest study being a Phase I/II trial (NCT04956575).

For these combo vaccines to solidify their real-world value, experts say their flu vaccine element should improve upon available standalone flu vaccines. Existing flu vaccines typically offer 4060% protection. The combo vaccine should have at least 60% of protection for better uptake, Rhode says.

In a Phase III trial (NCT04120194), Novavaxs NanoFlu had noninferior immunogenicity to the active comparator Sanofis Fluzone quadrivalent vaccine. Even though NanoFlu is only noninferior, the added Covid-19 element to its combo will give an additional selling point, Rhode explains. There are no concerns that the combo version will be less effective versus the standalone flu vaccine as Novavax is using the same technology in flu and its Covid-19 vaccines, he adds.

Its only recently that mRNA technology started being investigated for flu and the shift is due to the success of Covid-19 mRNA vaccines, says Dr Reynold Panettieri, Jr, Vice Chancellor, Rutgers Institute for Translational Medicine and Science. And the mRNA technology has potential in increasing the efficacy of existing influenza vaccines, explains Rhode.

Modernas standalone mRNA-1010 flu vaccine produced positive interim Phase I data showing boosted influenza antibody titres in the participants ages 18 and older. Novavax preclinical data shows its combo vaccine produced high titre influenza haemagglutination inhibiting (HAI) antibody response to a viral infection, neutralising antibodies against influenza A and B strains, and maintained protection against SARS-CoV-2.

Yet such positive preclinical data does not guarantee the same results in human trials, Rhode says. The human immune system responds differently to dosing, the tested drugs have different interference with human proteins and enzyme kinetics, as well as the effects of antibody response longevity when compared to laboratory animals, he explains.

The two combos should also demonstrate that the efficacy of its Covid-19 vaccine element should not be compromised by the added flu vaccine, Panettieri says. Reduced efficacy when combined is a valid concern that would affect its marketability, Rhode explains. Reassuringly, there are no examples of less-efficacious combo vaccines that are still distributed versus any standalone counterparts, he notes.

The combo vaccines are likely to have similar side effects to standalone versions, such as soreness, muscle fatigue, fever, and nausea, Rhode adds. So far, existing combo vaccines are as safe as standalone versions, Rhode and Panettieri note.

Nevertheless, if a combo vaccine is authorised, there are rollout issues that need to be addressed. There is an established seasonality to flu, which is why it is updated every year with a predictable schedule, adds John McCauley, director of the Worldwide Influenza Centre at the Francis Crick Institute.

Covid-19s seasonality, while there is a trend for winter peaks, is still nebulous and there are still questions if people should be given a Covid-19 vaccine annually to address waning efficacy, or only when there is an aggressive new variant that significantly impacts vaccine efficacy. You have to be really stringent and on top of your genomic surveillance. The world needs to continuously be looking at these strains and new variants, Rhode says.

Meanwhile, efforts for variant-specific or multivariant Covid-19 mRNA vaccines are also underway. While the first crop of Covid-19 mRNA vaccines demonstrated at least 90% efficacy against the original variant, approaching this high level of efficacy will be challenging at present due to vaccination rates in the community, immunity from prior infections, as well as more aggressive variants. Comparing previous and current immunogenicity data is like comparing apples to oranges, Panettieri says.

Nonetheless, there is nebulous practical and commercial value to these variant-specific or multivariant Covid-19 vaccines considering the original vaccines are still robust against all variants, Panettieri says. We have to be careful trying to perfect something that is not broken, he says. Boosters reduced the morbidity and hospitalization of infected patients, he added. Three doses of original Pfizer and Moderna vaccines had 90% protection against severe disease caused by the Omicron variant, according to the UKs Health Security Agency.

Further, by the time variant-specific or multivalent vaccines may be available in the market, the variants they are investigating against may no longer be circulating, a vaccine expert says. You will always be chasing your tail to a degree, he adds.

Instead, there should be more effort in improving vaccine distribution rather than improving upon a vaccine that is still efficacious, the vaccine expert says. Moderna has announced giving access to technology producing its Covid-19 vaccine to low- and mid-income countries, with BioNTech providing modular mRNA manufacturing facilities to improve vaccine supply in Africa.

Nonetheless, there is still scientific value in investigating these variant-specific or multivalent vaccines as they might be valuable if we do need them in the future, says the vaccine expert. A Pfizer spokesperson says staying vigilant against the virus requires identifying new ways to protect as SARS-CoV-2 naturally evolves. Developing and investigating different approaches, should they be needed, are essential towards their goal, she adds.

Moderna has said previous research on SARS-CoV-1 and MERS enabled the company to rapidly respond to the Covid-19 pandemic. Moderna and Novavax did not respond to the comment request.

Moderna is only investigating its vaccine as a booster, while Pfizer and BioNTech are also studying their vaccine in vaccine-nave people. While a significant number of people have received two doses, which argues for only investigating these as boosters, there are many people who are still vaccine-nave, particularly in places that are harder to reach, he added.

Reassuringly, variant-specific or multivariant vaccines are unlikely to pose a higher side-effect risk than the original version, Schaffner says. The side effects are attributed to the technology of the vaccine and not the antigen, he explains.

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How Social Media Memes, Palettes of Emotions And Intuitions, Make Us Who We Are – Outlook India

Posted: March 8, 2022 at 10:21 pm

The power of human imagination is endless and so is the realm of creativity. With greater access to the Internet and social media, more and more people are able to hone and harness their divergent thinking patterns these days. It is the basic human senses that help us observe the world around us. And that panoramic observation often leads to the evolution of the funniest visuals or graphics called memes.

A meme is like a palette of emotions and intuitions. They work with the idea of playing wicked, but not sleazy; you can connect with memes as easily as a five-year-old connects with any rough sketches. But whats the best way to describe it? Should it be termed as illustration or skill of using concise words with art to connect with the world?

What makes it so easy for us to connect with memes? Is it the play of emotions, the human element that makes us go, Oh My God! This meme is so me? Most of the time, it shows what we, as humans, feel, do or think; things which we may not feel comfortable expressing about, we have memes to do that for us. Be it happiness, sadness, enchantment, admiration, relief, calmness, confusion, nostalgia, entrancement, or boredom, memes help us vent it out. Memes are like a vocabulary for your emotions. They offer us a way to channelize the otherwise suppressed hysteria of life.

Be it in your heart, mind or soul, it straightens all the creases. Memes blend a pinch of sarcasm with a punch of humour. It stimulates your imagination, an exercise that further oils and sharpens your brains. With the changing times, reading books has kept us sane and alive all this while. Yet, one just cant deny how truly magnetic the field of art is vast and infinite. Memes are also works of art.

Nevertheless, Richard Dawkins, the man who coined the term meme in 1976, must be confused by its constant mutation: memes. He used the term to refer to an idea, behaviour or style that spreads from person to person within a culture. According to the genes-eye view theory Dawkins propounded, genes possess the required evolutionary longevity and they pass on their structure intact from one generation to the next. The theory of gene mutation finds a parallel in meme mutation.

There is more to what we call memes. Is it just the result of human creativity or something more? The damage the pandemic has wreaked could be irrevocable. Slowly, but steadily, we are all rolling with the punches; somewhere we have found new habits or ways of channelizing our emotions and anxieties. We enhance their appearance by giving them the form of art and presenting them to the world. These are then shared widely and circulated with a general acceptance of variegated human emotions. Sharing memes help each one of us connect with even those living in the most distant parts of planet earth, proving that the world is round.

Meanwhile, social media is doing its job of bridging the big generation gap between Gen X and the Digital natives. Visual arts, memes, and cultural trend reels are helping even those who feel technically crippled.

This has somewhere also increased the touchpoints that exist between the users. When people were homebound during Covid-19 lockdown, the pith and brevity of human creativity and memes kept them sane and uplifted.

In a nutshell, memes tickle our fancy, satiate our artistic appetites, apart from giving us brief moments of laughter and giggling.

(Hina Fatima Khan is an independent multimedia journalist, who thoroughly enjoys writing on social issues, space and world affairs)

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Sunflower Bean discuss Headful of Sugar and a return to the road – Kansas City Pitch

Posted: at 10:21 pm

Sunflower Bean. // Photo by DreilyS

Regarded as one of the hardest working bands from NYC, rock trio Sunflower Bean are currently on the road ahead of their upcoming third studio album Headful of Sugar. We caught up with Julia Cumming (lead singer/bass), Nick Kivlen (lead guitar), and Olive Faber (drummer) to discuss the bands history, returning to the road, and their third studio album out May 6.

The Pitch: We were first introduced to your music shortly after the release of your album Human Ceremony back in 2016. All of you are students of the game when it comes to rock music. Who were some of the artists or bands that inspired you to start playing?

Olive Faber: Ive been inspired by so many different kinds of music over the years. Around the time we started Sunflower Bean though, I think we all felt inspired by what was happening around us in NYC. Diiv, Heavens Gate, Night Manager, Total Slacker, Tonstartssbandht

New York has such a huge role in American music history. Can you talk about living there and how the various music scenes helped cultivate Sunflower Beans career when you were first starting?

Olive: I think the biggest thing for us was just having the opportunity to play live so often. Like there were so many venues and bands we were able to play shows three or four times a week.

A few months back you did an interview and talked about how after touring for five years straight, the lockdown at the beginning of 2020 forced you to re-evaluate a lot of different things. With your upcoming tour starting in March, how have your views on touring changed over the past few years?

Nick Kivlen: Im not sure because we havent done it yet, but I love touring so much. Im super excited. I love hotels, soundcheck, living communally, and constantly moving. The day-to-day schedule and routine. And of course, seeing the country in a very unique zoomed-in way has changed my life.

Olive: I think there will be a renewed appreciation for it.

In your latest single, Baby Dont Cry, Julia said something that really resonated: TV makes me so mad / NPR is always telling me something bad. As a Black, queer man in his mid-20s, its hard trying to build upon your career while dealing with different forms of bigotry from the music industry and the world in general. How do you find the balance of pursuing creative interests while taking care of your mental health?

Julia Cumming: Im really glad to hear that line resonated with you. There are no clear pathways in these fields, which is really terrifying and freeing. I feel like the way I deal with it now is to just check in with myself and be realistic about my needs. If I prioritize something, what are the consequences? I could work myself into the ground but then theres nothing to make art with.

Baby Dont Cry and Who Put You Up To This are from your third studio album Headful of Sugar. Without giving too much away, can you talk about what fans can expect?

Nick: The record is tough and determined but also extremely hopeful, and above all, fun. We wanted to make something gleefully powerful. You can read into the lyrics, but you can also just bob your head and feel empowered.

You three will soon be celebrating ten years together as a band. The music industry landscape has changed a lot over the past decade. What are some things that have contributed to your success and longevity as a band?

Nick: Our band is centered around us as a family. We also have a huge community of friends in New York who all play their roles in our band while using their creative skills. Three people who deeply connect at the center of all that support is a really special thing.

Sunflower Bean are currently on the road and will be performing at Off Broadway in St. Louis on March 12. Tickets here.

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Dermal Fillers Market to Cross Us$ 5,411.2 Mn by 2026, Increasing Awareness about Esthetic Appearance among People to Drive the Market – BioSpace

Posted: at 10:21 pm

Albany NY, United States: Transparency Market Research (TMR) has Published a new report titled, Dermal Fillers Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 20182026. According to the report, the global dermal fillers market was valued at US$ 2,584.9 Mn in 2017. It is projected to expand at a CAGR of 8.6% from 2018 to 2026. Expansion of the market can be attributed to technological advances leading to the development of newer hyaluronic acid dermal fillers with higher efficiency and long-lasting abilities, marketing strategies employed by market players, increasing awareness about these products on social media, and rising fad of anti-aging among people.

Biodegradables is anticipated to be a lucrative segment

The report offers detailed segmentation of the global dermal fillers market. Based on product, the market has been classified into biodegradable and non-biodegradable. The biodegradable segment dominated the market in 2017. It is likely to maintain its dominance during the forecast period. Biodegradable dermal fillers usually consist of purified dermal components derived from animal, human, or bacterial sources. Expansion of the segment can be attributed to the high safety profile of these fillers and recent technological advances that offer longevity on the usage of biodegradable fillers.

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Hyaluronic acid segment to expand at a robust CAGR

In terms of material, the dermal fillers market has been split into calcium hydroxylapatite, hyaluronic acid, collagen, poly-l-lactic acid, PMMA, fat, and others. The hyaluronic acid segment dominated the market in 2017. It is likely to maintain its dominance and expand at a high CAGR during the forecast period. More than 60% of dermal filler procedures performed globally are carried out with hyaluronic acid fillers. According to International Society of Plastic Surgeons (ISAPS), over 3,298,266 hyaluronic acid dermal filler procedures were performed annually.

Additionally, technological advances have led to the development of various forms of hyaluronic acid dermal fillers, which differ according to the concentration of hyaluronic acid and the degree of crosslinking. These are known to enhance the longevity of the filler effect. These factors are anticipated to drive the market.

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Rising fad of anti-aging driving the facial line correction treatment segment

Based on application, the dermal fillers market has been segregated into facial line correction treatment, lip enhancement, scar treatment, and others. The facial line correction treatment segment dominated the market in 2017. It is likely to continue the trend and expand at a high CAGR during the forecast period. Expansion of the segment can be attributed to the rising trend of anti-aging and increasing awareness about esthetic appearance among people.

Additionally, facial line correction treatment appeals to varied age demographic, ranging from young adults to enhance their youthful features to middle-aged adults for volume restoration and older individuals to maintain age-related symptoms. Marketing strategies employed by market players, wherein celebrities promote their products, are fueling the desire among the population to mimic their favorite celebrities. This, in turn, is boosting the demand for facial line correction treatment procedures.

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Dermatology clinics to expand at high CAGR

In terms of end-user, the market has been split into hospitals, ambulatory surgical centers, dermatology clinics, and others. In terms of revenue, the hospitals segment dominated the market in 2017. It is likely to maintain the trend during the forecast period. However, the dermatology clinics segment is anticipated to expand at a robust growth rate during the forecast period. Robust expansion of the segment can be attributed to the increase in dermatology consultations and surge in preference for specialist dermatologists.

Growth in Asia Pacific to be driven by Japan and India

In terms of revenue, North America dominated the global dermal fillers market in 2017. The U.S. was the major revenue generating country in the region. Expansion of the market in the country can be attributed to a rise in the number of dermal filler procedures performed annually. According to American Society of Plastic Surgeons (ASPS) over 2.3 million dermal filler procedures were performed in 2017, an increase of over 3% over 2016. The market in Asia Pacific is expected to expand at a high CAGR during the forecast period. Expansion of the market in the region can be attributed to the increasing demand for dermal filler procedures in Japan, India, and China. Hyaluronic acid dermal filler procedures are highly common non-surgical procedures performed in various countries across Asia Pacific, including Japan, China, India, and Thailand.

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Strategic acquisitions is a key strategy adopted by key players

The report provides profiles of leading players operating in the global dermal fillers market. These players include Allergan plc, Sinclair Pharma (a subsidiary of Huadong Medicine Ltd), Merz Pharma GmbH & Co. KGaA, Nestle Skin Health (Galderma), BioPlus Co., Ltd., Bioxis pharmaceuticals, SCULPT Luxury Dermal Fillers LTD, Dr. Korman Laboratories Ltd., Prollenium Medical Technologies, Advanced Aesthetic Technologies, Inc., and TEOXANE Laboratories.

For instance, in 2014, Nestle acquired several dermatology brands owned by Canada-based pharmaceuticals group Valeant, which added a range of dermal fillers to the Nestle skincare business. Nestles skincare business was established through the acquisition of Galderma. In the same year, Allergan acquired Aline hyaluronic acid (HA) thread technology from Aline Aesthetics, a wholly owned subsidiary of TauTona Group.

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Hospital Infection Therapeutics Market: The global hospital infection therapeutics market is characterized by increase in incidence of infections of resistance bacteria. The market is witnessing gradual rise in research and development activities to develop novel antibiotics, which are supported by government policies.

Vaginal Slings Market: Rising prevalence of urinary incontinence, increasing number of vaginal slings procedures, and intensive research activities being performed to determine the efficacy of vaginal slings over other surgery and procedures are some factors that are estimated to propel the vaginal slings market during the forecast period.

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Dermal Fillers Market to Cross Us$ 5,411.2 Mn by 2026, Increasing Awareness about Esthetic Appearance among People to Drive the Market - BioSpace

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Understanding Caste and the Power of Empathy in Human Health – University of California San Diego

Posted: March 6, 2022 at 9:30 pm

Empathy is not a weakness, Pulitzer Prize-winning author Isabel Wilkerson told a live audience gathered virtually to hear her insights into an artificial division that continues to plague society known as caste, and its contribution to health injustice.

Empathy is a window into the fellow members of our species. Empathy is a superpower that would heal the world if we could only harness it, said Wilkerson.

Dedicated to building a more equitable and just health care system and educational pipeline through engaged empathy and compassion, the UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science, the Center for Empathy and Social Justice and Human Health at the T. Denny Sanford Institute for Empathy and Compassion, and UC San Diego Health invited Wilkerson to discuss her research into the history of caste in the United States and the resulting No. 1 New York Times bestseller she authored, Caste: The Origins of Our Discontents.

Isabel Wilkerson

It was not a book that I wanted to write, Wilkerson told the UC San Diego audience. It was a book that called to be written, insisted upon being written in the era that we find ourselves in.

The intense national conversation about anti-Black racism, structural and systemic racism, and the historic number of deaths during the COVID-19 pandemic can be partly explained by societal divisions, she said.

There are many, many reasons why we find ourselves in a current crisis. But caste and the divisions that it sells surely are among them, said Wilkerson.

Wilkerson defined caste as an artificial, arbitrary graded ranking of the human value in a society designed to keep people in a fixed place. She compares caste to bones, the invisible structure that forms the basis of our divisions. While race, like skin, is the visible manifestation of where a person is assigned within a caste system.

In the U.S., Black and Latino communities faced a disproportionate number of COVID-19 cases and deaths. However, COVID-19 is not the first public health crisis to highlight health disparities among individual populations.

Differences in access to health care and treatments, quality of care, culturally competent resources and research that is not representative of the community adds to health care inequities.

Dr. Crystal Wiley Cen

The road to health, healing, equity, and social justice starts with a conversation. Conversations like this, and the history and science that they are grounded in, will give us a common language, framing and knowledge to guide our work, said Dr. Crystal Wiley Cen, chief administrative officer for healthy equity, diversity and inclusion at UC San Diego Health.

Armed with this foundational knowledge, we can then do the continual work required to transform our organization into one that is truly anti-racist. In doing that, we will not only transform ourselves, but our city and surrounding communities.

UC San Diego Health, the regions only academic hospital system, is setting yearly antiracism goals for the institution to achieve and has built equity, diversity and inclusion into its overall strategic framework for how it operates as a health system, said UC San Diego Health CEO Patty Maysent

Whether we realize it or not, what happens in our communities can affect how we approach our work, and as health care providers, we need to ensure that every patient receives the respect and fairness he or she deserves, said Maysent. Hopefully, supporting conversations like the one with Isabel Wilkerson can help us continue on our anti-racism journey.

During her research for the book, Wilkerson met a Nigerian immigrant in his 50s who was shocked to find himself diagnosed with high blood pressure and diabetes, something he attributed to living his adult life as a Black man in the U.S. given that his 90-year-old father in Nigeria did not suffer from either of these conditions.

Gentry N. Patrick

This is a reminder that many of the of the health inequities that might show up in the bodies of Black people are not as a result of genetics, said Wilkerson. They are a result of the exposure constantly pressing against the expectations and constantly having to address and navigate a society that has been hostile to them and to people who look like them going back centuries.

Dismantling the causes of health inequities requires identifying necessary changes to policies and system level structures, said Gentry N. Patrick, director of the Center for Empathy and Social Justice in Human Health.

Each of us here today must do our part in our respective spaces to commit to those changes in order to eradicate health injustice, said Patrick. Importantly, these changes must be rooted in compassionate action by rephrasing the landscape of health equity through the lens of casteism. We can re-envision our path to success and, to borrow a term from Ms. Wilkerson, the role that radical empathy must play.

Nothing will change unless people recognize the unconscious biases that has been programmed into our society, said Wilkerson.

People are walking around with worsened health as a result of the effect of 400 years of the social order that has been built into the infrastructure of our systems and has permeated our subconscious to the degree that it does, said Wilkerson. And, it has health consequences for everyone. Our collective health is worse than other nations.

Wilkerson said the country is in a unique situation to learn from recent events to expand our definition of who we are as a nation and to remake ourselves in a way that's more holistic, more humane, more empathic and more compassionate.

Cheryl A.M. Anderson

Cheryl A.M. Anderson, founding dean of the Herbert Wertheim School of Public Health and Human Longevity Science and inaugural Hood Family Endowed Deans Chair in Public Health, believes the country is poised and ready for change.

This conversation will kick off and energize what weve been intellectually describing to catalyze a more equitable health care culture and system. We are all coalesced around this concept so let's build systems and structures that really put our next generation ahead of where we are today, said Anderson.

Higher education institutions and their leadership have a responsibility to define and effectively commit to their own accountability for improved justice in health care via systemic change as well as in public health research and interventions.

UC San Diegos Office for Equity, Diversity and Inclusion (EDI) leads the universitys efforts to cultivate a welcoming campus climate where all students, faculty and staff have the resources they need to thrive. This includes leading UC San Diegos Strategic Plan for Inclusive Excellence, which is deeply connected to the UC San Diego Strategic Plan. The Office for EDI also oversees the Center for Faculty Diversity and Inclusion and the six campus community centers that serve as places for belonging, open dialogue and education about identity and social justice as well.

In addition, numerous educational and advocacy programs engage the campus community, including the Black Academic Excellence Initiative, which works to foster an environment of equity, diversity, and inclusion for our Black community. In addition, the Latinx/Chicanx Academic Excellence Initiative was formed as a holistic infrastructure of support and community. UC San Diego is an emerging Hispanic-Serving Institution with a 20% population of students who identify as Latinx/Chicanx.

Ultimately, it is the collective impact of students, faculty and staff across the university that makes a difference. There are numerous ways to move from awareness to action, including participation in the White Allyship, Action & Accountability Initiative. The self-paced educational program is open to people of all races and ethnicities with a focus on engaging white campus community members in organizing and partnering to eliminate systemic racism.

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Improving quality of life and longevity in communities is topic of Tulsa Town Hall – Tulsa World

Posted: at 9:30 pm

Fridays speaker at the Tulsa Town Hall lecture series challenged Tulsans to think collectively rather than individually about improving longevity and quality of life.

Nick Buettner is director of community and corporate programs for the Blue Zones Project, a community-wide well-being improvement initiative based on lessons gleaned from locales around the globe with the highest concentrations of people living to 100 years and beyond.

He began with a quick audience survey of predictors of longer-than-average life expectancy: Do you sleep at least 7 hours five days a week? Do you eat at least three full servings of vegetables and get at least 30 minutes of vigorous exercise daily?

Had no unprotected sex during the last year? Belong to a faith-based institution and attend three times per month? Do you have three good friends who would answer if you call on a bad day? Have you not smoked in the past five years?

Do you actually want to live to 90?

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If you raised your hand all eight times, youre dismissed I have nothing to teach you, Buettner ended the survey, prompting uproarious laughter.

The Blue Zones Project, which was founded by Buettners brother and best-selling author Dan Buettner, is based on observations and scientific data from centers of extraordinary human longevity including Ikaria, Greece; Sardinia, Italy; Nicoya, Costa Rica; Okinawa, Japan; and Loma Linda, California.

The Blue Zones Project aims to improve the quality of life and longevity of individuals through community-wide improvements in cities, states and even within workplaces.

Unlike many health or wellness initiatives, the Blue Zones Project addresses the environment, not just individual behavior changes in an effort to have widespread, long-term impacts.

The nearest locale to try it has been the Pottawatomie County Blue Zones Project, which began in 2017, Buettner said.

For example, instead of nagging people to exercise, communities can make walking not only the healthy choice but also the easier choice through sidewalk improvements and walking initiatives.

And communities can work together to make wholesome foods more accessible at schools, restaurants and food banks so people in Blue Zones begin to eat healthier naturally.

The crux of Buettners message is what his brother dubbed The Power 9, the common lifestyle habits found in the worlds healthiest, longest-lived people.

The first is to move naturally. What does that mean?

It doesnt mean going to a gym or training for marathons, which Buettner said the vast majority of people wont sustain as a habit. Its about habitually walking or biking to a friends house, to the grocery store, to school, or gardening and other active activities.

Next is purpose. Buettner said the loss of purpose and engagement, with that reason to get up each morning, is what makes people 30% more likely to die in the year after they retire.

The Japanese call it Ikigai, which translates to lifes purpose.

Third is having routines to shed stress, or what Blue Zones calls down shift. This varies by centers of longevity and includes praying, napping and even regular happy hours with friends and family.

Fourth is the 80% rule: Stop eating before your stomach is all the way full as a simple means of managing caloric intake. Buettner said people in the Blue Zones also eat their smallest meal in the late afternoon or early evening and dont eat again until the next day.

Fifth is having a happy hour of one to two glasses of wine regularly and that does not translate to having 14 drinks on the weekend, Buettner said.

Sixth, active, regular engagement in faith-based communities was common across all centenarians studied by the Blue Zones Project.

Seventh was a mostly plant-based diet.

And no, Buettner said that doesnt mean vegan or vegetarian. But in large centenarian clusters, cow milk is not part of the diet, meat is limited to fewer than five meals per month and fish to three times or fewer per week; water, tea, coffee or wine are the common beverages consumed.

Eighth is a family-first priority in life, including not just children but also maintaining a life partner and caring for nearby, aging parents and grandparents.

Lastly is what Blue Zones refers to as having the right tribe. Simply put, it means being in social circles with people with similarly healthy habits and behaviors.

Buettner said it is critical for communities to identify what is working and what isnt and to implement the kinds of changes that make healthy choices easier to make.

To date, 56 communities and 4,823 organizations participate in the Blue Zones Project, but the lessons about what improvements work are applicable most everywhere and urgently needed, he said.

The life expectancy of our kids is less than our own, Buettner said. We spend $3 trillion on health care costs for (preventable) diseases.

201 E. Second St.

An ideal place for people-watching, the ground-floor patio is open to the public. As always, we LOVE the cheese-fries.

222 S. Kenosha Ave.

The patio area at this new addition to the East Village neighborhood wraps around two sides of the building, giving diners plenty of vantage points from which to watch lifes rich pageant. The food has a distinctive Middle Eastern flair, paired with its range of craft cocktails, wines and beers.

1816 Utica Square

Queenies Plus moved up the sidewalk this year to a larger space, complete with a much larger patio area that faces 21st Street. Its the perfect place to enjoy a breakfast treat or lunch.

1551 E. 15th St.

The restaurants staff used the down-time to spruce up its patio area and space out the tables to put more distance between groups of diners. Otherwise, the same good vibes and fine foods remain at this Cherry Street hot spot.

1740 S. Boston Ave.

The Tulsa Worlds pick as the best restaurant of 2020 has a covered patio outside its entrance, equipped with fans and heaters, to allow diners to savor chef Lisa Becklunds 10-course tasting menu in the cool of the evening.

1820 Utica Square

The Wild Fork is another Tulsa landmark that took advantage of the lockdown to transform itself, with a completely renovated interior and slightly slimmed down menu. The restaurants sidewalk seating was also given a boost with new seating and an expanded footprint. The food and the people watching are just as good as ever.

3324 E. 31st St.

Bird & Bottles neighbors gave the restaurant permission to put tables out on the sidewalks to augment the small open space it uses for outdoor seating. Its something of a secluded spot, but its likely youll be too focused on chef Stephen Lindstroms food to miss any people-watching.

319 E. Archer St.

The interior of the new French Hen is spectacular, to say the least. But the restaurants patio area gives one the sense of dining at a Parisian outdoor cafe in the middle of downtown Tulsa. Whether enjoyed inside or out, chef Kathy Bondys food is superb.

817 E. Third St.

One of Tulsas finest restaurants just happens to have one of the citys finest patios. Thats one reason why it fills up quickly, as seating here is first-come, first-served.

9999 S. Mingo Road

One of the more spacious patios of any local restaurant can be found at this south Tulsa restaurant, where people can enjoy its specialty burgers and craft beers as well as a bit of the great outdoors.

1324 S. Main St.

What general manager Tracey Sudberry once described as the most under-utilized space in the Ambassador Hotel was transformed earlier this year with louvered awnings, fans and heaters, new tables and chairs, to create a comfortable space in which to enjoy the Chalkboards acclaimed cuisine.

108 N. Detroit Ave.

Duets patio also serves as the stage for many of the local, regional and national jazz acts that perform there regularly. But its also a good place to enjoy Duets array of good food and libations.

4532 E. 51st St.

When this outpost of a small regional chain moved into town, it completely transformed the space once home to the Green Onion, adding a spacious patio on the buildings north side.Its a good place to work ones way through the restaurants extensive drinks menu.

201 W. Fifth St.

About half a dozen or so tables take up the patio area of this family restaurant, which is almost always full on pleasant days. Enjoy one of the variations of pho, the savory broth loaded with noodles and your choice of proteins.

1124 S. Lewis Ave.

Mother Road Market reopened its patio area to give its merchants who werent able at the time to handle curbside delivery a way to serve their customers. Now, with the markets app, one can have just about any dish from any vendor delivered to ones socially distanced table.

318 E. Second St.

Arnies renovated its courtyard area last year, adding a stone fireplace and a mosaic of the classic Lovely Day for a Guinness image.

514 S. Boston Ave.

Libby Billings helped kickstart the parklet boom in downtown Tulsa, turning a parking space or two into a welcoming place to enjoy Elotes signature puffy tacos and other area-sourced Mexican specialties.

121 S. Elgin Ave.

Hotel Indigos rooftop patio, home to the Roof Sixty-Six Bar, boasts some of the best views of Tulsa. Because the patio faces west, visitors are also able to grab epic sunset photos during their stay.

3509 S. Peoria Ave.

Cafe Ol has been a dining destination on Brookside for 30 years, serving up Southwestern-inspired cuisine with some Oklahoma flair. The Tin Pan Tuesday specials let you sample street foods for $2 each, and the housemade queso is a must.

Mayo Hotel, 115 W. Fifth St.

Almost 20 stories off the ground, what better way to enjoy a specialty cocktail and one of Tulsas phenomenal sunsets?

818 E. Third St.

This East Village spot has a cozy patio space that is the perfect place to enjoy some treats, such as the Craigies Angry Bee pizza, which tempers the bite of hot peppers with honey.

122 N. Boston Ave.

Amelias offers patio seating in the heart of the Tulsa Arts District. Enjoy a glass of wine or one of the wood-fired pizzas while people-watching on the patio.

7501 E. Kenosha St., Broken Arrow

The Rocking R Ranch House at Forest Ridge Golf Club offers patio seating in nice weather. Try the Sweet Heat shrimp appetizer, featuring crispy shrimp tossed in a sweet and spicy aioli.

111 N. Main St.

Right in the heart of the Tulsa Arts District, Laffa Medi-Eastern Restaurant and Bar has a great patio to watch the world go by. Check out the Mezze Medley small shareable plates with a huge piece of laffa bread. Our favorites are the West African hummus with sweet potatoes and peanuts, or the Anatolian labneh, a creamy yogurt dip.

304 S. Elgin Ave.

Enjoy a view of the Tulsa skyline at the biergarten at Fassler Hall. Grab a beer and an order of duck fat fries.

1004 E. Fourth St.

Grab a brew and relax in the outdoor area at Dead Armadillo Brewery.

325 E. Reconciliation Way

Pizzas dominate the menu of this family-friendly sports bar, with its 55 TV screens. One of the more unusual, but tasty, choices is the white potato thin potato slices topped with pecorino cheese, rosemary and onion on a relatively thin and crispy crust.

River Spirit Casino Resort, 8330 Riverside Parkway

The patio of the Margaritaville restaurant is part of a triple-decker outdoor venue. Above Margaritaville is the Salty Bar, an area typically reserved for private events, with lounge furniture and a dedicated bar area. On the ground level is the Landshark Pool Bar, which serves the resorts guests in the lounge pool and the hungry and thirsty trekkers along the River Parks trails.

Oren

3509 S. Peoria Ave., Suite 161

This stunning restaurant on Brookside features a plush patio that is perfect for drinks.

3523 S. Peoria Ave.

The front patio is good for people-watching in Brookside, and the back courtyard has been popular among evening diners. Both are dog friendly. Try the shrimp and grits.

8921 S. Yale Ave.

The patio was the main reason owner Todd Billingsly took over the space that used to be Jamesons Pub, to make it a venue for live music and televised sports, as well as dining.

3301 S. Peoria Ave.

Bricktown Brewery in Brookside specializes in local and regional craft beers. As for the food, the Loaded Nachosaurus is a perfect partner for a flight of beers.

402 E. Second St./211 S. Elgin Ave.

Guests can get a two-for-one deal here. The Dilly Diner courtyard has a bocce ball court, picnic tables and playhouses for the kids. The quirky Dust Bowl patio has artificial grass-covered sofas and spring stools. A walkway connects the two.

7031 S. Zurich Ave.

This companion restaurant to McNellies Pub downtown has become a popular destination spot for south Tulsans looking for a great brew, outstanding pub food and a good time. We recommend the lobster roll or the top-flight fish and chips.

151 Bass Pro Drive, Broken Arrow

300 Riverwalk Terrace, Jenks

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Don’t overemphasize tolls on the highway to longevity – Daily Herald

Posted: at 9:30 pm

Many experience increasing "aches and pains" as the years roll on. Most older people have a litany of joints and body parts that hurt. We eventually realize conversations with friends, relatives and neighbors are often dominated by recounting all these medical conditions and complaints.

Common topics are high cholesterol, high blood pressure, arthritis, stiff joints and doctor visits -- all sorts of problems. Sometimes it's not just the person you're speaking to -- you often get reports about what their friends and neighbors are going through.

Usually people just say, "It's is part of aging."

However, we actually know many of these problems can be avoided with a healthful diet and proper exercise, caution and other preventive health care. Yet, being human, often we do not follow these measures, so here come aches and pains.

I'm not talking about serious illness, accidents or surgeries, which of course must be addressed and communicated. We all need support, and need to support each other, when a big health issue strikes. And of course we must tell our loved ones and close friends what happened. I know, personally, I hope to be kept up to date on these matters and would feel terrible if not kept in the loop.

I'm talking about day-to-day chitchat and constant complaining about aches and pains. Before we know it, conversations are almost totally dominated by reports of medical issues and concerns. Over and over. Now, this becomes a danger zone. Right after the weather, this becomes the new "small talk."

It cannot be healthy for mind or body to have every casual conversation taken over by telling medical stories and reports. And to make it worse, these tend to be negative and complaining conversations, which are not healthy for the spirit. There are other matters to discuss -- and uplifting stories to tell.

Recently a friend told me she was together with friends for dinner when one said: "Do you realize we've been talking for an hour and no one has mentioned even one medical thing?" So they laughed. But it's true. It's hard for people to avoid the medical topic.

What shall we do about this?

First thing that comes to my mind is self-protection. In my experience, it's not good to be constantly engaged in worry and complaints. Change the topic.

When people sincerely want to know, they ask.

People live to be real old these days, which is a blessing. I just read an essay that "80 is the new 60."

If we ignore health advice about diet and exercise, that's a choice.

And some of those aches and pains are simply a toll we pay on the highway of longevity. They are one topic of course, but not the whole phone call or meeting.

The point is: In my experience, we need to take this in hand and consciously avoid constant "medical complaint" conversations and not let them dominate our minds and interactions with friends and relatives. It's a matter of selection and balance.

There are other interesting and important matters to discuss. Let's not have these endless complaints and stories be the new small talk.

Susan Anderson-Khleif of Sleepy Hollow has a doctorate in family sociology from Harvard, taught at Wellesley College and is a retired Motorola executive. Contact her at sakhleif@comcast.net or see her blog longtermgrief.tumblr.com. See previous columns at http://www.dailyherald.com/topics/Anderson-Kleif-Susan.

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93% Indians live with air quality below WHO standards; life expectancy reduced by 1.5 years: Study – Times of India

Posted: at 9:30 pm

A whopping 93 per cent of Indians live in areas where air pollution levels exceed WHO standards, according to a global report.The report revealed that life expectancy in India, as a result, has been shortened by about 1.5 years.The findings by Health Effects Institute (HEI) in Washington, US, is part of its annual State of Global Air annual analysis for 2020.The study showed that with an average annual population-weighted PM2.5 of 83 microgram/ cubic metre (mg/cu) in 2019, as many as 9,79,700 deaths in India can be attributed to PM 2.5.

It showed that almost 100 per cent of the world's population lived in areas where the PM2.5 levels exceeded WHO recommendations - which is average annual PM2.5 exposure levels of 5 mg/cu.

On average, more than 40 per cent of the world's population lives in areas where ozone levels exceeded the least stringent WHO interim target in 2019.

Globally, India ranks ninth highest population exposure to ozone (98 per cent), following countries like Congo, Ethiopia, Germany, Bangladesh, Nigeria, Pakistan, Iran and Turkey taking the top eight positions and China ranking 10th.

"Air pollution is a leading risk factor for deaths and disability around the world; in 2019 alone, exposure to air pollution was linked to 6.7 million deaths," the authors wrote in the study.

The large exposure to PM2.5 has also reduced life expectancy for countries and regions -- Egypt (2.11 years), Saudi Arabia (1.91 years), India (1.51 years) China (1.32 years) and Pakistan (1.31 years).

The lowest impacts of pollution on longevity is in Norway, Sweden, Australia, and New Zealand.

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Library : Alliance of Generations Is Indispensable – Catholic Culture

Posted: at 9:30 pm

by Pope Francis

Pope Francis General Audience Address March 2, 2022

In his second reflection in a new catechetical series on old age, Pope Francis said the earliest moments of human history required a slow and prolonged initiation, as human beings, created in Gods image and likeness, yet bearing the fragility of mortal existence, needed time to decipher experiences and confront the enigmas of life. During that same time, he said, the spiritual quality of man was also slowly cultivated.

Vatican, March 2, 2022

Dear brothers and sisters, good morning!

In the Bible account of the genealogies, one is immediately struck by their tremendous longevity: we are talking about centuries! When does old age begin here, we wonder? And what is the significance of the fact that these ancient fathers live so long after fathering their children? Fathers and sons live together for centuries! This passage of time in terms of centuries, narrated in a ritual style, confers a strong, very strong symbolic meaning to the relationship between longevity and genealogy.

It is as though the transmission of human life, so new in the created universe, demanded a slow and prolonged initiation. Everything is new, at the beginnings of the history of a creature who is spirit and life, conscience and freedom, sensibility and responsibility. The new life human life immersed in the tension between its origin in the image and semblance of God, and the fragility of his mortal condition, represents a novelty to be discovered. And it requires a long initiation period, in which mutual support among generations is indispensable in order to decipher experiences and confront the enigmas of life. During this long time, the spiritual quality of man is also slowly cultivated.

In a certain sense, every passing epoch in human history offers this feeling again: it is as if we had to start over calmly from the beginning with our questions on the meaning of life, when the scenario of the human condition appears crowded with new experiences and hitherto unasked questions. Certainly, the accumulation of cultural memory increases the familiarity necessary to face new passages. The times of transmission are reduced, but the times of assimilation always require patience. The excess of speed, which by now obsesses every stage of our life, makes every experience more superficial and less nourishing. Young people are unconscious victims of this split between the time on the clock, that needs to be rushed, and the times of life, that require a proper leavening. A long life enables these long times, and the damages of haste, to be experienced.

Old age certainly imposes a slower pace: but they are not merely times of inertia. Indeed, the measure of these rhythms opens up, for all, spaces of meaning of life unknown to the obsession with speed. Losing contact with the slower rhythms of old age closes up these spaces to everyone. It is from this perspective that I wished to establish the feast of grandparents, on the last Sunday of July. The alliance between the two extreme generations of life children and the elderly also helps the other two young people and adults to bond with each other so as to make everyones existence richer in humanity.

There is a need for dialogue between the generations: if there is no dialogue between young people and the elderly, if there is no dialogue, each generation remains isolated and cannot transmit the message. Think: a young person who is not bonded to his or her roots, which are the grandparents, does not receive the strength, like the tree, the strength of the roots, and grows up badly, grows up ailing, grows up without points of reference. Therefore, it is necessary to seek, as a human need, dialogue between generations. And this dialogue is important between grandparents and grandchildren, who are the two extremes.

Let us imagine a city in which the co-existence of the different ages forms an integral part of the overall plan of its habitat. Let us think about the formation of affectionate relations between old age and youth that irradiate out onto the overall style of relations. The overlapping of the generations would become a source of energy for a truly visible and livable humanism. The modern city tends to be hostile to the elderly (and, not by chance, also to children). This society, that has this spirit of rejection: it rejects so many unwanted children and it rejects the elderly. It casts them aside they are no use to rest homes, hospitals, there The excess of speed puts us in a centrifuge that sweeps us away like confetti. One completely loses sight of the bigger picture. Each person holds on to his or her own piece, that floats on the currents of the city-market, for which slower pace means losses and speed is money. The excess of speed pulverizes life: it does not make it more intense. And wisdom it takes to waste time. When you return home and see your son, your daughter, and you waste time, but in this conversation that is fundamental for society, you waste time with children; and when you come home and there is the grandfather or grandmother who is perhaps no longer lucid or, I dont know, has lost something of the ability to speak, and you stay with him or with her, you waste time, but this waste of time strengthens the human family. It is necessary to spend time, time that is not lucrative, with children and with the elderly, because they give us another ability to see life.

The pandemic, in which we are still forced to live, has imposed very painfully, unfortunately a halt to the obtuse cult of speed. And in this period, grandparents have acted as a barrier to the affective dehydration of the youngest. The visible alliance of the generations, that harmonizes pace and rhythms, restores to use the hope of not living life in vain. And it restores to each of us the love for our vulnerable lives, blocking the way to the obsession with speed, which simply consumes it. The key word here to each one of you, I ask: do you know how to waste time, or are you always in a hurry? No, Im in a rush, I cant. Do you know how to waste time with grandparents, with the elderly? Do you know how to spend time playing with your children, with children? This is the touchstone. Think about it. And this restores to each person the love for our vulnerable life, blocking the road of the obsession with speed, which simply consumes it. The rhythms of old age are an indispensable resource for grasping the meaning of life marked by time. The elderly have their rhythms, but they are rhythms that help us. Thanks to this mediation, the destination of life to the encounter with God becomes more credible: a design that is hidden in the creation of the human being in his image and likeness and is sealed in the Son of God becoming man.

Today there is a greater longevity of human life. This gives us the opportunity to increase the covenant between all times of life. So much longevity, but we must make more alliance. And this also helps us to increase with the meaning of life in its entirety. The meaning of life is not only in adulthood, say, from 25 to 60 years no. The meaning of life is all of it, from birth to death, and you should be able to interact with everyone, and also to have emotional relationships with everyone, so that your maturity will be richer and stronger. And it also offers us this meaning of life, which is everything. May the Spirit grant us the intelligence and strength for this reform: a reform is needed. The arrogance of the time of the clock must be converted into the beauty of the rhythms of life. This is the reform we must make in our hearts, in the family and in society. I repeat: what must we reform? The arrogance of the time of the clock must be converted into the beauty of the rhythms of life. The alliance of the generations is indispensable. A society in which the elderly do not speak with the young, the young do not speak with the elderly, is a sterile society, without a future, a society that does not look to the horizon but rather looks at itself. And it becomes lonely. May God help us to find the right music for this harmonization of the various ages: the little ones, the elderly, adults, everyone together: a beautiful symphony of dialogue. Thank you.

Greeting in English

I greet the English-speaking pilgrims and visitors taking part in todays Audience, especially the groups from Norway, Ireland and the United States of America. May the Lenten journey we begin today, with prayer and fasting for peace in Ukraine, bring us to the joy of Easter with hearts purified and renewed by the grace of the Holy Spirit. Upon each of you, and your families, I cordially invoke Gods abundant blessings.

Libreria Editrice Vaticana 2022

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Now You Have A Reason To Exercise – Longevity LIVE – Longevity LIVE

Posted: at 9:30 pm

When it comes to aging, research shows that, next to genetics, lifestyle habits are the biggest shapers of the human body. That means your destiny is largely in your hands, and not your DNA. This should be enough to motivate you to fine-tune your diet, start a regular exercise routine and ensure you get eight hours of sleep.

Is this enough though? The healthy lifestyle drill is something weve all become accustomed to, so why do we tend to revert to our old habits? Perhaps this is down to following trends because we think we ought to, rather than really wanting to. The want needs to come from within and, post-lockdown, we now have a choice and, more importantly, a reason.

Our priority should be focused on building a strong immune system and looking after our mental health. And what better way to start than with exercise?

When you exercise and learn to relax, your immune system lifts, cortisol, and blood pressure levels go down, and your mood is enhanced. Bone density increases with weight-bearing exercise; you have improved joint mobility, and a stronger heart and lungs.

Nowadays, with many of us working from home, its become clear that we dont need the most high-tech gym equipment to get a great workout, but still, theres Im pressed for time when it comes to taking action and getting to exercise.

A workout Ive been teaching for years that has finally been given an official name. Peripheral heart action is a time-efficient training formula that gives you a great CV workout, while simultaneously toning up the muscles all in one session.

It can be completed almost anywhere with minimal equipment, such as light weights and resistance bands. Your own home can save you time traveling to and from the gym, but it can also be done in the gym, incorporating both resistance training and CV equipment.

The theory behind PHA training is that, by alternating between upper and lower-body exercises, the heart has to work harder to divert blood from one end of the body to the other, which is further enhanced with bursts of CV training. However, Ive also found that switching between the upper and lower body allows you to achieve more without realizing how hard youre working because you work the lower body to fatigue and then rest it while you train the upper body, and so on.

Whatever your current level of fitness, incorporating even two PHA sessions into your schedule will make significant improvements to your fitness levels and all-around conditioning.

Once youre into the PHA routines, youll notice changes fairly rapidly, and realize just how effective and challenging they are. Its certainly a smart way for time-pressed individuals to train with or without lockdown.

Prepared by Jenni Rivett

Equipment needed: a chair, 6-8kg kettlebell, 2kg dumbbells

Warm-up for 5 minutes.

REPEAT ABOVE ROUTINE

REPEAT ABOVE ROUTINE

Photo by AirFit from Pexels

REPEAT ABOVE ROUTINE

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