Category Archives: Human Longevity

A new study suggests that there may be a simple way to help reduce the risk of liver cancer and extend lifespan: consume mushrooms, soy, whole grains, aged cheese, and other foods rich in spermidine.

Researchers found that mice fed an oral supplement of spermidine were less likely to develop liver fibrosis and hepatocellular carcinoma (HCC) - the most common form of liver cancer - compared with rodents that did not receive the supplement.

Furthermore, the research team - from Texas A&M University in College Station - found that spermidine increased the lifespan of mice by as much as 25 percent.

Study co-author Leyuan Liu, Ph.D., of the Institute of Biosciences & Technology at Texas A&M, and colleagues recently reported their findings in the journal Cancer Research.

Spermidine is a polyamine - a compound that has at least two amino groups - that was originally isolated from sperm, hence its name. Spermidine is also naturally found in a variety of food products, including aged cheese, mushrooms, legumes, soy, whole grains, and corn.

Previous research has suggested that dietary spermidine may have health benefits. One study published in Nature Medicine last year, for example, associated oral supplementation of spermidine with better heart health and longevity in mice, while a more recent study linked the compound to reduced blood pressure.

For this latest study, Liu and colleagues investigated whether spermidine might have anti-cancer properties.

To reach their findings, the researchers gave an oral spermidine supplement to mice that were predisposed to develop HCC or liver fibrosis - that is, a buildup of scar tissue in the liver that can lead to liver cancer.

Not only were the mice less likely to develop HCC or liver fibrosis than rodents that were not given the spermidine supplement, but they were also found to live much longer.

"It's a dramatic increase in lifespan of animal models, as much as 25 percent," says Liu. "In human terms, that would mean that instead of living to about 81 years old, the average American could live to be over 100."

The authors note that the 25 percent increase in lifespan was only seen in mice that had lifelong spermidine supplementation; rodents that were given the supplement later in life experienced a 10 percent increase in longevity.

In previous research, Liu and team found that lack of autophagy - the process by which cells "eat" their own debris - contributed to cancer development.

In this study, the researchers found that the benefits of spermidine diminished in the absence of a protein called MAP1S, which is known to trigger autophagy. As such, the team speculates that the cancer-protective effects of the compound are down to its enhancement of MAP1S-related autophagy.

Further studies are needed to determine the safety and efficacy of spermidine supplementation in humans, but the team believes that it could offer significant health benefits.

"Just think: if we added spermidine to every bottle of beer, it might balance out the alcohol and help protect the liver," says Liu.

"It's still early, but perhaps one day this approach will provide a novel strategy to prolong lifespans, prevent or reverse liver fibrosis, and prevent, delay, or cure hepatocellular carcinoma in humans."

Leyuan Liu, Ph.D.

Learn how having children may increase lifespan.

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Compound in aged cheese may prevent liver cancer, boost longevity - Medical News Today

Maybe it wasnt exactly scientifically confirmed, but it was nonetheless clear that Saturdays March for Science in downtown Athens not a march, exactly, as things turned out exceeded the limits of the police-issued permit for the event in front of the federal courthouse on Hancock Avenue.

I think weve broken the law, folks! an exuberant Mark Farmer, a cellular biologist at the University of Georgia, told the crowd jamming the courthouse lawn from the steps into the street.

Because the local March for Science part of hundreds of such marches held around the world on Earth Day coincided with the popular G-Day intrasquad University of Georgia football game that brings thousands of visitors to town, organizers couldnt get a parade permit for downtown Athens, according to Farmer.

Instead, they were granted a permit to rally on the federal courthouse grounds outside the heaviest G-Day traffic from 11 a.m. until noon, with a limit of 400 people. But one glance around the crowded lawn made it clear that the actual number of people was well above that limit, with one estimate placing the crowd at 600 people or more, who waved signs and chanted as a line of speakers extolled the human progress made possible by science.

And, with a little lighthearted civil disobedience in his heart, as the rally was winding down Saturday morning, Farmer looked at the permit and said, I see nothing on here saying you cant all take your signs and walk downtown!

The Athens event and those held worldwide were aimed at promoting an understanding of science and defending science from issues such as proposed federal government budget cuts that could adversely affect scientific research in this country.

Waving signs with slogans like Grab them by the data and Science is not a liberal conspiracy, the hundreds of people who attended the March for Science in downtown Athens heard from a number of speakers including Marilyn Williams, the director of spiritual care at St. Marys Hospital in Athens.

Prior to becoming a chaplain, Williams worked for two decades in cancer research and health care management, and she spoke Saturday about the nexus between science and religion.

Theres no conflict between the two, she said. Both are just different approaches for understanding our world.

And, Williams said, pastoral care work shows the connection between faith and science.

We really do see where science and faith come together, she said. Theyve always been connected.

Also speaking Saturday was Kathy Fowler, a veterinarian and march organizer who suggested to the crowd that without science particularly the medical research that has improved human health and longevity many of the people at Saturdays march might not have been there.

The scientific discoveries of the the last few centuries are what allowed you to be here today, she said.

Human health has also been improved by scientific advancements in water quality and in properly handling wastewater, Fowler continued.

They all came about because of scientific research and discovery, she said.

The local focus on science will continue in neighboring Oconee County on Sunday, where the Oconee County Democrats will host a nonpartisan event called Walk and Talk with a Scientist.

The walk is scheduled for 3 to 5 p.m. at Herman C. Michael Park off Georgia Highway 53 and Elder Road. Scientists will gather at the walking trail, which is paved and about a third of a mile long.

People can choose a scientist and walk the trail with them while talking about that persons scientific investigations or study. Among the scientists participating in the event are a geologist, an expert in water toxicity, a botanist, a specialist in endangered species and an expert on coral reefs.

Across the United States on Saturday, one of the organizers of the first Earth Day, Denis Hayes, said the crowd he saw on the National Mall in Washington appeared energized and magical, almost like what he saw on the first Earth Day 47 years ago.

Hundreds turned out in light rain for a pro-science rally on the Vermont Statehouse lawn in Montpelier. One of the speakers, Rose Paul, director of conservation science for The Nature Conservancy of Vermont, told the crowd that Science is not a partisan issue. She said climate change is happening and scientists are needed to help understand how shifting weather patterns are affecting the world.

In Nashville, Tenn., hundreds of people braved pouring rain, marching through city streets and chanting science, not silence.

President Donald Trump said in an Earth Day statement that his administration is committed to keeping our air and water clean, to preserving our forests, lakes and open spaces and to protecting endangered species.

But that wont be done, he said, in a way that harms working families, and he added that the government is reducing unnecessary burdens on American workers and American companies, while being mindful that our actions must also protect the environment.

The Associated Press contributed to this report.

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Hundreds in Athens join worldwide marches for science - Online Athens

DUANVALE, Jamaica Violet Brown spent much of her life cutting sugarcane in the fields around her home in western Jamaica. She attended church regularly, avoids pork and chicken and celebrated her 117th birthday last month.

On Saturday, she is believed to have become the world's oldest living person following the death of Emma Morano of Italy, born Nov. 29, 1899.

Brown told The Associated Press she is surprised but grateful to have lived this long.

"This is what God has given me, so I have to take it long life," Brown said in an interview in her home in the town of Duanvale.

Brown is considered to be the oldest person in the world with credible birth documentation, according to Robert Young, director of the supercentenarian research and database division at Gerontology Research Group, a network of volunteer researchers into the world's oldest people. Its website says she was born on March 10, 1900.

Brown has not yet been declared the world's oldest by Guinness World Records, considered to be the official arbiter of the oldest person title but Guinness depends heavily on Young's group. Young said he has met Brown and examined her birth certificate, which was issued by the British authorities who governed Jamaica at the time of her birth.

"She's the oldest person that we have sufficient documentation for at this time," Young said.

Jamaica's prime minister congratulated Brown on Twitter.

Guinness said it was researching a number of candidates for the new world's oldest person title.

"It can be a uniquely complex and sometimes lengthy process," Guinness spokeswoman Elizabeth Montoya said. "There is no confirmation of a new title holder until our thorough processes are complete."

Brown has two caregivers and spends most of the day resting in the home she shares with her 97-year-old son. She is able to sit up by herself and walk short distances. And while she is hard of hearing, she offered swift, complete responses to questions about her life and family.

The secret to long life is hard work, she said.

"I was a cane farmer. I would do every work myself," she said. "I worked, me and my husband, over that hill."

She also credited her Christian faith for her long life.

"I've done nearly everything at the church," she said. "I spent all my time in the church. I like to sing. I spent all my time in the church from a child to right up," to today, she said.

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At 117, world's oldest woman works hard and avoids pork - Greensboro News & Record

Researchers found that a protein in human umbilical cord blood plasma improved learning and memory in older mice, but there's no indication it would work in people. Mike Kemp/Rubberball/Getty Images hide caption

Researchers found that a protein in human umbilical cord blood plasma improved learning and memory in older mice, but there's no indication it would work in people.

Decades ago, scientists surgically attached pairs of rats to each other and noticed that old rats tended to live longer if they shared a bloodstream with young rats.

It was the beginning of a peculiar and ambitious scientific endeavor to understand how certain materials from young bodies, when transplanted into older ones, can sometimes improve or rejuvenate them.

From the beginning, the findings were exciting, complex and, sometimes, contradictory. For example, scientists have shown that young blood can restore cell activity in the muscles and livers of aging mice. They've also found that linking old mice to young ones helped reverse heart muscle thickening.

On the other hand, researchers weren't able to replicate some of the most eye-catching findings and another study concluded that, in mice that swapped blood without being connected surgically, the negative effects of being exposed to old blood outweighed the benefits of getting young blood.

What was clear was that, like humans, as mice age their bodies and their behavior change on a fundamental level. For example, older mice stop building nests, and they tend to become forgetful, taking a long time to remember how to escape from a maze.

"We see a pretty dramatic difference between young and aged mice in terms of their performance," says Joe Castellano, a neuroscientist at Stanford University School of Medicine.

Castellano and his colleagues wondered if young human blood might have beneficial effects for aging mice.

Now, they report in the journal Nature that they've found a protein in human umbilical cord blood that improved learning and memory in aging mice. It's an exciting find in the field of regenerative medicine.

But, scientists caution, it does not mean people should start ordering umbilical cord blood online. There is no indication that it would work in humans.

For their study, Castellano and his colleagues collected plasma, which is the watery part of blood, from people of different ages. Some were in their 60s and 70s, others in their 20s. They also collected plasma from human umbilical cords.

Then, they injected human plasma from those different age groups and from umbilical cord blood into mice several times over the course of a couple of weeks.

The mice were 12 and 14 months old, which is approximately the mouse equivalent of being in your late 50s or 60s.

When they dissected the mouse brains and inspected the hippocampi, they found that certain genes linked to making new memories had been turned on in some of the mice.

"So, we had a hint early on that one of these donor groups, specifically the [umbilical] cord plasma, might be having an effect on the brain itself," he says.

Next, they injected more aging mice with human plasma and tested the animals' ability to remember things.

For example, they watched how long it took the mice to escape from a maze the mice had done before, using visual cues to choose an exit that would lead to safety.

Castellano says it's basically like observing a person try to navigate through a crowded garage to locate their parked car.

Before being injected with umbilical cord blood, Castellano says, "their performance wasn't very impressive." It took them a long time to learn and remember the location of the escape hole, and some of them didn't manage at all. "But after cord plasma treatment, both the time [it took to] find it, the rate at which they'd find it and the fact that they do find it was improved and changing," he says.

Similarly, mice treated with human umbilical cord blood performed better on a second memory test. That test involved introducing mice to a chamber and then delivering a little shock to their feet. Mice that remembered the unpleasant experience would, when reintroduced to the chamber, freeze in anticipation of the shock. A forgetful mouse, on the other hand, would go about its usual business.

Castellano says the mice that had received umbilical cord plasma froze more often.

"We were, first of all, surprised and excited that there was something in human plasma, and more specifically there's something exciting about cord plasma," he says.

After a series of other experiments, Castellano and his colleagues concluded that one protein, called TIMP2, in human umbilical cord blood was likely responsible for the improvement.

When they removed TIMP2 from cord plasma and injected the plasma into mice, they didn't observe any improvement on the memory tests. And when they injected plasma containing TIMP2 into elderly mice, they again observed improvement in memory and learning tasks.

"The really exciting thing about this study, and previous studies that have come before it, is that we've sort of tapped into previously unappreciated potential of our blood our plasma and what it can do for reversing the harmful effects of aging on the brain," says Castellano.

It's an intriguing hint at how potential therapies might someday work to prevent age-related illness, including Alzheimer's disease, from developing.

"The desired outcome is overall whole body rejuvenation," says Aubrey de Grey, a biomedical gerontologist who founded the SENS Research Foundation.

The study by Castellano and colleagues, he says, is an "excellent" starting point.

"The only thing, of course, is that it's a mouse experiment and mouse experiments often don't actually translate faithfully into the human setting," he says.

And Castellano agrees that this finding does not mean that people should start sprinkling TIMP2 protein on their cereal or signing up for umbilical cord transfusions.

First off, he says, there's no evidence that elderly humans would experience the same effects as the mice did in this study. It's also unclear what would happen to mice if they received the plasma for more than just a few weeks.

There's also the nagging worry that, while proteins like TIMP2 may be beneficial for developing babies, they could be harmful in older humans.

"Maybe there's a reason that older brains aren't exposed to certain proteins any longer," says Castellano.

And Irina Conboy, who studies aging and degenerative diseases at the University of California, Berkeley, points out that the TIMP2 protein is actually present in higher levels in people with Alzheimer's disease.

That runs counter to the argument made by Castellano and colleagues that TIMP2 is associated with improved memory and learning, and that TIMP2 levels would drop as people age.

"TIMP2 is a very well-known protein," she says. She also notes that one of Castellano's co-authors, Tony Wyss-Coray, is the board chair for a company called Alkahest, which has separately studied plasma injections as a potential treatment for Alzheimer's.

And, Conboy says, there is no indication that the TIMP2 Castellano and colleagues detected in mouse brains actually came from the injections of human plasma. It's unclear, she says, whether a protein in plasma could actually make its way from a mouse's bloodstream into its brain, or that, once there, it could actually impact brain function.

Last year, Conboy published a study in which she and colleagues swapped half of the blood in old mice with that of young mice, and vice versa. They saw signs of regeneration in the muscles and liver.

But, says Conboy, "There was zero positive effect on the brain. The mice were not smarter. They did not learn better."

Such conflicting results reflect two fundamentally different ways of thinking about aging.

From the point of view of Castellano and colleagues, aging involves a loss of beneficial materials; for example, diminishing amounts of proteins that were once present in the plasma.

To Conboy, however, "The problem is not that you run out of positive things, but that you accumulate negative things."

She and others hold that proteins likely accumulate with old age, sometimes inhibiting certain functions, including the growth of new cells.

"We have hundreds of proteins that change with age," she says, and finding a way to reduce the effects of aging will likely require tinkering with a huge bouquet of them.

"If you are looking for miracles, it will not come from [injecting] bodily fluids," she says. "There will not be one silver bullet."

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Human Umbilical Cord Blood Helps Aging Mice Remember, Study Finds - NPR

The world's oldest person Violet Brown, center, poses with her care givers Elaine Mcgrowder , left, and Dolet Grant at her home in Duanvale district of Trelawny, Jamaica, Sunday, April 16, 2017. The 117-year-old woman living in the hills of western Jamaica is believed to have become the world's oldest person, according to groups that monitor human longevity. (AP Photo/Raymond Simpson)

KINGSTON, Jamaica (AP) The son of a woman believed to be the oldest person in the world died at their home Wednesday in Jamaica at the ripe old age of 97.

Harland Fairweather, who had recently been ill but had seemed to recover, awoke saying he felt dizzy and then deteriorated over the course of the morning, said Elaine McGrowder, one of two family caretakers who were at the home at the time.

"He had been unwell for some time but we didn't expect him to go like this," McGrowder said.

Fairweather lived with his 117-year-old mother, Violet Brown, in the rural northwestern Jamaican community of Duanvale. He was born and raised there but spent much of his life in Britain, the caretaker said in a phone interview with The Associated Press. "He was a beautiful man very, very special," she said.

Brown is considered to be the oldest person in the world with credible birth documentation, according to the Gerontology Research Group, a network of volunteer researchers into the world's oldest people.

Guinness World Records, considered to be the official arbiter of the oldest person, said it was still researching a number of candidates for the new world's oldest person title following the death Saturday of 117-year-old Emma Morano of Italy.

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Son of world's oldest woman dies at 97 at home in Jamaica - Trinidad & Tobago Express

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Longevity

April 19th, is National Garlic Day.Cathy Isom tells you how you may pay homage to a stinky vegetable that is also known as natures wonder drug.Thats coming up on This Land of Ours.

Garlic, which is dubbed the Stinking Rose because of its overpowering taste and smell,dates back more than 6,000 years ago. Its a member of the Lily family, which also includes onions, leeks and shallots. Its great in many culinary cuisines. But its also known for its wide-reaching medicinal properties in treating illness and disease. Garlic are rich in protein, Vitamin A, B-1 and C and contains essential minerals such as calcium, magnesium and iron. The U.S. is the 6th top producer of garlic in the world. With much of its supply coming out of Gilroy, California, a town about an hour southeast of San Francisco, known as the self-proclaimed as the Garlic Capital of the World. Will Rogers was once quoted as saying it is the only place in America where you can marinate a steak just by hanging it out on a clothes line.

Im Cathy Isom

From: National Garlic Day

Regarded as a force of both good and evil, the Egyptians are said to have fed the herb to workers building the Great Pyramid of Giza because they believed it boosted their stamina. In the Middle Ages, plague-phobic Europeans ate whole cloves of garlic to fight off the scourge known as the Black Death.

The herb, which can also be deemed a vegetable too, is rich in protein, vitamins A, B-1 and C and contains essential minerals such as calcium, magnesium and iron. It also contains 17 different amino acids.

Link:
National Garlic Day - AgNet West

Humans start getting ready to die as soon as they are born. But for some, that process takes a whole lot longer than it does for everyone else.

Take Italys Emma Morano. She was officially the worlds best live-r before passing away at 117 on Saturday, according to The Chicago Tribune. She was born on November 29, 1899Guinness World Records says that would have made her the last known person born in the 19th century. What do you do to live that old?

You do nothing. It just happens. Then you die anyway.

In the world of aging sciences, if you want to live a long life, choose long-lived parents, S. Jay Olshansky, Professor in the School of Public Health at the University of Illinois at Chicago, told Gizmodo. Thats always rule number one. Olshansky, a human longevity expert, walked us through how aging really works.

As a courtesy, newspapers always ask the oldest living person what their secret is. Morano said she ended an abusive marriage and ate raw eggs and cookies. Jeanne Louise Calment used to be the oldest person ever and lived to 122; she ate two pounds of chocolate per week and quit smoking at 119. Thats nice, but those lifestyle choiceswhere they lived and what they ate probably didnt do much.

Lifestyle is far from the whole story when it comes to your lifespan. There are a lot more people alive today compared with when Morano was born, so there will naturally be a lot more centenarians in the future. The world population has increased over 4 times since 1900, and the infant mortality rate has dropped a whole lot, from 100 babies per 1000 in 1900 to around 7 per 1000 births in 1999, according to the Centers for Disease Control and Prevention. Were treating diseases better, and our geriatric care is adding years onto people who may have died at 90, said Olshansky.

That means most of the things you can do to lengthen your life are being done for you already. Your decisions can only shorten it. We expose ourselves to the sun, we dont exercise, we eat things we shouldnt be eating, he said. Theres lots of things we can do to accelerate the aging process, but decelerating it is still a mystery.

As far as how the centenarians get to live so long, Olshansky believes their biological clocks simply tick slower (and that those of women tick slower than those of men). The visible aging processes and physiological signs like cell division might happen at a slower rate, possibly due to genetic factorshe pointed out that really old folks generally look younger throughout their life. But this is something that lots of folks around the world are still researching.

So, you will die, the decisions youre making are probably making your life shorter, you probably wont live to be 100, and if you do, its not because you drank red wine, snorted antioxidants or bathed in coconut oil. You got lucky. Chaos reigns.

[Chicago Tribune, Guinness World Records]

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The Last Person Born in the 1800s Died and So Will You - Gizmodo

BBC News

World's oldest person Emma Morano dies at 117 BBC News The world's oldest person has died in Italy at the age of 117, reports say. Emma Morano was born on 29 November 1899 in the Piedmont region of Italy. She was officially the last person born in the 1800s still living. She had attributed her longevity to ... World's oldest person dies, aged 117Radio New Zealand Jamaican woman now oldest person aliveJamaica Observer Emma Morano, World's Oldest Person, Dies at 117 Years OldComplex FITSNews -The Straits Times -JOE all 68 news articles »

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World's oldest person Emma Morano dies at 117 - BBC News

Texas A&M started a new chapter in clinical research on April 11 with the grand opening of the Human Clinical Research Facility.

The College of Education and Human Development hosted the event from 1 p.m. to 5 p.m. The Clinical Research Facility will be home to both the Center for Translational Research in Aging and Longevity and the Exercise & Sports Nutrition Lab. To start off the event, audience members listened to guest speakers and participated in group tours around the building, showcasing the new labs and equipment.

Human Clinical Research Facility will help the college to narrow its research focus, according to the Director for the Center for Translational Research in Aging and Longevity Dr. Nicolaas Deutz.

It focuses on the clinical research, so thats a real plus of having the building on campus, Deutz said. Besides that, I think its a very good place for other researchers on campus to start working with us to do more clinical research because in the end, that is what we want.

Deutz said this step into the field of clinical research will be worthwhile for the university as a whole.

Clinical research was actually missing on campus, so if we can do more clinical research we will become a better university, with more money and appreciation by others, Deutz said.

U.S. Representative and guest speaker at the grand opening Bill Flores said there are many benefits to be gained from clinical research and that the university can change lives.

I commend Texas A&M for its commitment to expand the research activities conducted by this university, Flores said, This commitment not only improves Texas A&M, it improves opportunities and life here in the Brazos Valley and all across Texas and the Nation. Actually across the world.

Flores said by opening the Human Clinical Research Facility, A&M is going back to its original purpose.

What's being done with this facility and this program follows as closely as you can get to the land grant mission of Texas A&M University, Flores said.

Head of Exercise & Sports Nutrition Lab and Department of Health & Kinesiology Richard Kreider said the wide variety of research resources in this one location is what makes the Human Clinical Research Facility unique.

We can do overnight stay studies, outpatient studies, training and do all the analyses all in house, Kreider said. Almost everyone else has a place they have to go to do the training or rehab then they have to collect samples in one place and go to another place for analyses. Its all here and we are working collaboratively.

Kreider said the core characteristics of the Aggie spirit also make the Human Clinical Research Facility stand out.

Aggies are bold, Kreider said. They envision. Lead by example and find a solution to societal problems. That is what makes us special. That is what draws so many great faculty and students here. Thats what keeps us here. Today's grand opening of a beautiful research facility is yet another example of how Texas A&M University system has led by example.

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A&M opens Human Clinical Research Facility - Texas A&M The Battalion