Category Archives: Genome

SINGAPORE & SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--

The Genome Institute of Singapore (GIS), an institute under the umbrella of the Agency for Science, Technology and Research (A*STAR), and Fluidigm Corporation (FLDM) today announced the establishment of the first research center in Asia exclusively dedicated to accelerating the understanding of how individual cells work, and how diagnosis and treatment might be enhanced through insight derived from single cells. The GIS-Fluidigm Single-Cell Omics Center (SCOC) is expected to act as a focal point for collaborative efforts among single-cell genomics researchers across the region.

The SCOC will be a visionary academic-industry partnership designed to provide integrated analytics for single-cell genomic applications to the regions researchers. This interdisciplinary center will bring together molecular and cell biologists and provide them with genomics and genotypic data for their assessment of biological pathways, disease mechanisms and the characterization of healthy and diseased tissues.

The center will provide single-cell analytics across a diverse collection of stakeholders such as drug discovery firms, pharmaceutical and biotech companies, academia and clinics. The SCOC is targeted to provide single-cell infrastructure across Singapore and Asia that will engage various disciplines in an adaptive multi-source platform.

An example of one of the early projects that the SCOC will tackle is defining early embryonic cellular state spaces using single-cell transcriptomics through mRNA sequencing. This project will be led by GIS Senior Group Leader Dr. Paul Robson. The measurement of the transcriptome at the single-cell level is the most accessible method to define cell states with digital gene expression patterns providing the state space coordinates. This project aims to define a minimal set of signaling and regulatory genes capable of defining the attractor and transitional cellular states spaces in existence early in human development.

The SCOC will be housed in dedicated laboratory space at GIS facilities in Biopolis, Singapore. It will feature the full capabilities of Fluidigms new C1 Single-Cell Auto Prep System and the Fluidigm BioMark HD System for gene expression analytics and validation. In addition, the center will have access to various NGS capabilities for sequencing.

GIS is one of the worlds premier centers for human genetics studies, genomic discovery, and the pursuit of integrating technology, genetics and biology towards the goal of individualized medicine. Drs. Paul Robson and Bing Lim, GIS Senior Group Leader and Associate Director, Cancer Stem Cell Biology, will oversee the initial projects run through the SCOC.

GIS Executive Director Prof Ng Huck Hui said, GIS has identified Single-Cell Genomics as one of our new research frontiers. We are set up to build a repertoire of new research capabilities for single-cell analyses. Our initial collaboration with Fluidigm has borne fruit with the publication of a landmark paper by Dr. Paul Robson. This larger and very important collaboration will see an even greater synergy between the technologies from GIS and Fluidigm.

With the creation of the SCOC, we assemble a strong multidisciplinary consortium of academia and industry, and an interdisciplinary team of senior scientists, engineers and informatics specialists with very deep knowledge and skills in analyzing cellomics and genomics information. This will create a platform for information-sharing in a collaborative manner designed to deliver fast execution from concept to results, said Dr. Michael Rossbach, Head of the GIS Office of Business Development.

The Single-Cell Omics Center is a major boost to the emerging, burgeoning field of single-cell analysis and we are thrilled to be part of it together with GIS, said Gajus Worthington, President and Chief Executive Officer of Fluidigm. GIS has a track record of publishing breakthroughs based upon single-cell research, so this center can act as an accelerant for more new science. In addition, we expect the SCOC will stimulate more single-cell genomics research throughout Asia, Worthington concluded.

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Genome Institute of Singapore and Fluidigm Establish Asia’s First Single-Cell Genomics Research Center

Richard Dawkins mdash; Sex, Death and the Meaning of Life (2/3) [Multi sub]
#1069; #1090; #1086; #1090; #1085; #1086; #1074; #1099; #1081; #1092; #1080; #1083; #1100; #1084;- #1088; #1072; #1079; #1084; #1099; #1096; #1083; #1077; #1085; #1080; #1077; #1056; #1080; #1095; #1072; #1088; #1076; #1072; #1044; #1086; #1082; #1080; #1085; #1079; #1072; #1085; #1077; #1086; #1090; #1086; #1084;, #1089; #1091; #1097; #1077; #1089; #1090; #1074; #1091; #1077; #1090; #1041; #1086; #1075; #1080; #1083; #1080; #1085; #1077; #1090;. #1042; #1085; #1077; #1084; #1080; #1089; #1089; #1083; #1077; #1076; #1091; #1102; #1090; #1089; #1103; #1075; #1086; #1088; #1072; #1079; #1076; #1086; #1073; #1086; #1083; #1077; #1077; #1089; #1083; #1086; #1078; #1085; #1099; #1077; #1074; #1086; #1087; #1088; #1086; #1089; #1099;, #1090; #1072; #1082; #1080; #1077; #1082; #1072; #1082;: " #1095; #1090; #1086; #1087; #1088; #1086; #1080; #1089; #1093; #1086; #1076; #1080; #1090; #1082; #1086; #1075; #1076; #1072; #1084; #1099; #1080; #1076; #1077; #1084; #1076; #1072; #1083; #1100; #1096; #1077; #1080; #1086; #1089; #1090; #1072; #1074; #1083; #1103; #1077; #1084; #1088; #1077; #1083; #1080; #1075; #1080; #1102; #1087; #1086; #1079; #1072; #1076; #1080;?", " #1095; #1090; #1086; #1073; #1091; #1076; #1077; #1090; #1085; #1072; #1087; #1088; #1072; #1074; #1083; #1103; #1090; #1100; #1080; #1074; #1076; #1086; #1093; #1085; #1086; #1074; #1083; #1103; #1090; #1100; #1085; #1072; #1089; #1074; #1084; #1080; #1088; #1077;, #1089; #1074; #1086; #1073; #1086; #1076; #1085; #1086; #1084; #1086; #1090; #1074; #1089; #1077; #1093; #1073; #1086; #1075; #1086; #1074;?", " #1082; #1072; #1082; #1072; #1090; #1077; #1080; #1089; #1090; #1085; #1072; #1093; #1086; #1076; #1080; #1090; #1089; #1084; #1099; #1089; #1083; #1074; #1078; #1080; #1079; #1085; #1080;?", " #1082; #1072; #1082; #1084; #1099; #1084; #1086; #1078; #1077; #1084; #1089; #1084; #1086; #1090; #1088; #1077; #1090; #1100; #1074; #1083; #1080; #1094; #1086; #1089; #1084; #1077; #1088; #1090; #1080; #1073; #1077; #1079; #1091; #1090; #1077; #1096; #1077; #1085; #1080; #1103; #1079; #1072; #1075; #1088; #1086; #1073; #1085; #1086; #1081; #1078; #1080; #1079; #1085; #1080;?", #1080; " #1082; #1072; #1082; #1085; #1072; #1084; #1088; #1072; #1079; #1083; #1080; #1095; #1072; #1090; #1100; #1076; #1086; #1073; #1088; #1086; #1080; #1079; #1083; #1086;?" ______________________________________________ Evolutionary biologist Richard Dawkins asks if science can provide answers to the big questions we used to entrust to religion Richard Dawkins explores what science can tell us about death. It #39;s a journey that takes him from Hindu funeral pyres in India to genetics labs in New York. Dawkins brings together the latest neuroscience, evolutionary and genetic theory to examine why we crave life after death, why we evolved to age and how the human genome is something like real immortality - traits inherited from our distant ancestors that we pass on to future generations. He meets a Christian dying of motor neurone disease, reminisces about the Wall Street Crash with a 105-year-old stockbroker, and interviews James Watson, the geneticist who co-discovered the structure of DNA. Dawkins admits to sentimentality in imagining his own church funeral, but he argues we must embrace the truth, however hard that is. In a television first, he has his entire genome sequenced to reveal the genetic indicators of how he himself ...From:lolollloloViews:44 1ratingsTime:47:07More inScience Technology

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Richard Dawkins — Sex, Death and the Meaning of Life (2/3) [Multi sub] - Video

11/25/12 - Pinned Down - Mutiny - Saint
In this game Saint, and Genome tried to rush the left side to see if we could capture the red brick building. We knew that our other guys would be able to grab the boat so we thought if we captured this building, we could push them back one house at a time. We ended up not making it to that building... they had to many people there and they had little distance to get there. Hope you guys like the footage!From:IllestAirsoftViews:48 1ratingsTime:08:01More inEntertainment

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TCGA 2012 Poster Session
November 27-28, 2012 - The Cancer Genome Atlas #39; 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA More: http://www.genome.govFrom:GenomeTVViews:7 1ratingsTime:09:32More inScience Technology

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Sequenced Pig Genome Creates Opportunities for Health Research
An international scientific collaboration that includes two CVM researchers is bringing home the bacon when it comes to potential animal and human health advancements, thanks to successfully mapping the genome of the domestic pig. The sequenced genome gives researchers a genetic blueprint of the pig. It includes a complete list of DNA and genes that give pigs their traits like height and color. Once all of the genetic information is understood, scientists anticipate improvements to the animal #39;s health as well as human health, as pigs and humans share similar physiologies. "With the sequenced genome we have a better blueprint than we had before about the pig #39;s genetics and how those genetic mechanisms work together to create, such as the unique merits in disease resistance," said Dr. Yongming Sang, research assistant professor in the Department of Anatomy and Physiology. For three years, Dr. Sang worked on the genome sequencing project with Dr. Frank Blecha, associate dean for the College of Veterinary Medicine and university distinguished professor of anatomy and physiology. A report of the international study appears as the cover story for the Nov. 15 issue of the journal Nature. To read more of the November issue of Lifelines, go to http://www.vet.k-state.eduFrom:KSUCVMViews:3 0ratingsTime:04:04More inEducation

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Evolution of gymnosperm
For more information, log on to- shomusbiology.weebly.com Download the study materials here- shomusbiology.weebly.com There are between 800 and 900 extant or currently living species of Gymnosperms. It is widely accepted that the gymnosperms originated in the late Carboniferous period.[5] This appears to have been the result of a whole genome duplication event around 319 million years ago.[6] Early characteristics of seed plants were evident in fossil progymnosperms of the late Devonian period around 380 million years ago. It has been suggested that during the mid-Mesozoic era, pollination of some extinct groups of gymnosperms were by extinct species of scorpionflies that had specialized proboscis for feeding on pollination drops. The scorpionflies likely engaged in pollination mutualisms with gymnosperms, long before the similar and independent coevolution of nectar-feeding insects on angiosperms.[7][8] Conifers are by far the most abundant extant group of gymnosperms with six to eight families, with a total of 65-70 genera and 600-630 species (696 accepted names).[9] Conifers are woody plants and most are evergreens.[10] The leaves of many conifers are long, thin and needle-like, others species, including most Cupressaceae and some Podocarpaceae, have flat, triangular scale-like leaves. Agathis in Araucariaceae and Nageia in Podocarpaceae have broad, flat strap-shaped leaves. Cycads are the next most abundant group of gymnosperms, with about 130 species. The other ...From:Suman BhattacharjeeViews:0 0ratingsTime:13:46More inEducation

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Probing the Effect of Conformational Constraint on Binding
TACC Vis Showcased at SC12 Anne Bowen, Texas Advanced Computing Center. Work in collaboration with Yue Shi, UT Biomedical Engineering Increasing the strength of binding between a molecule and a receptor is an important technique in the design of effective drugs. One experimental technique to increase the strength of binding (called "binding affinity") is to synthesize molecules that are already in the shape that it will take when bound to a receptor. This technique works because it decreases the binding entropy which increases the overall binding affinity. A recent experimental study of a series of receptor-molecule complexes (the Grb2 SH2 domain with peptide analogues) aimed to increase the binding affinity by introducing a bond constraint. However, the constrained molecules had less favorable binding entropies than their flexible counterparts. Yue Shi of the Ren lab at UT Austin aimed to probe the origin of this entropy paradox with molecular dynamics simulations which were run on Lonestar and Ranger at TACC. Their group used approximately 2 million CPU hours on Ranger and almost 1 million on Lonestar this past year. Their research addresses biological and medical challenges from single molecules to the genome with high performance computing and theory. In collaboration with other experimental groups, they utilize computer modeling and simulations to understand these complex biomolecular systems and to discover molecules for treating disease and improving human health ...From:TACCutexasViews:1 0ratingsTime:00:10More inScience Technology

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Probing the Effect of Conformational Constraint on Binding - Video

Austin Brown "Slow Down" - Pandora Whiteboard Sessions
Austin Brown performs "Slow Down" for Pandora Whiteboard Sessions 12.6.12 Pandora Oakland HQ Over the years the Pandora office has had the great pleasure of receiving visits from many of these talented musicians and comedians. Some are well-established artists in town for a major show, others are in the middle of a grassroots tour, hitting coffee houses and small clubs up and down the West Coast. Sometimes we just meet up to show them around the office and learn about their careers, other times our employees are treated to a short performance. We also take the opportunity to show them the Music Genome Project and walk them through an analysis of their music, along with some data on their audience on Pandora. It #39;s been fun to see their reaction when they learn which songs are the most "thumbed up" or how large their audience is, and what areas around the country are particularly enthusiastic for their sound. This performances take place in front of a giant whiteboard in a common area of the Pandora Oakland office. On the day of the show one of the Pandora designers creates a unique drawing to represent each artist on the white board, which becomes the backdrop for the performance. The Whiteboard Sessions are unique because the daytime office environment calls for a different kind of performance than what people normally see at concerts. These sessions are mostly acoustic and there is a lot of interaction with the crowd. And there #39;s lots of improvising too - recycling bins ...From:pandoraViews:3 9ratingsTime:04:49More inMusic

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IT Insider - Cliff Farrah on "The Problem with Big Data"
"Like" us on Facebook: on.fb.me Follow us on Twitter: bit.ly Big Data is everywhere these days from Google and LinkedIn to mapping the genome, so why does Cliff Farrah, President and Chairman of Beacon Group Consulting say that businesses are just not getting it? In a recent publication for Beacon #39;s Fortune 500 clients, Farrah lays out the nine reasons Big Data is not being adopted and what he says needs to be done about it. Farrah recommends a strategy for streamlining the Big Data industry as whole and identifying areas of growth and opportunity. Join host Richard Schlesinger as he addresses "The Problem with Big Data" on this episode of "IT Insider".From:EMCCorpViews:0 0ratingsTime:27:55More inScience Technology

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UC Berkeley AMP Lab Genomics Project on AWS - Customer Success Story
The AMP Lab at the University of California Berkeley builds scalable machine learning and data analysis technologies to turn data into information. Among the many experiments run by the AMP Lab, one area of concentration is in the field of genomics and cancer research. Due to the vast amount of data that genome sequencing produces, the AMP Lab leverages Amazon Web Services (AWS) to quickly scale the compute resources needed to analyze the algorithms that are used in genomics work. As a result, researchers are able to use many machines in the cloud simultaneously to process genome data faster and more cost effectively. To learn more about how AWS helps universities, researchers and analytics teams solve the big data problem, visit aws.amazon.comFrom:AmazonWebServicesViews:2 0ratingsTime:03:24More inScience Technology

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UC Berkeley AMP Lab Genomics Project on AWS - Customer Success Story - Video