Category Archives: Genome

Jan. 7, 2013 Fox Chase Cancer Center, a National Cancer Institute-designated Comprehensive Cancer Center, is now offering patients with advanced cancer a cutting-edge clinical test that will provide them with a unique blueprint of their cancer genes.

The new clinical test, known as CancerCode-45TM, evaluates an individual's tumor for genetic alterations in a select group of 45 genes and gives physicians the opportunity to look at the alterations and be even more precise when choosing a course of treatment. The test is being offered through the Cancer Genome Institute at Fox Chase -- one of only a few centers in the nation to offer such pioneering technology in cancer molecular diagnostics.

"Gaining insight like this into the DNA of a specific tumor is the next step in transforming cancer care and prevailing over cancer," says Michael V. Seiden, MD, PhD, president and CEO of Fox Chase. "We are very excited to be offering this innovative test at our Center and look forward to the ways it will enhance the care we provide our patients."

Using leading-edge technology, physicians and scientists at Fox Chase are able to perform the CancerCode-45 test and analyze the genetic information in the DNA of a patient's tumor to find changes that are crucial to supporting their cancer. This genetic analysis will examine multiple alterations in 45 cancer-related genes and provide a report to the patient's treating physician.

Prior to the CancerCode-45 test being performed, patients will need to see a Fox Chase physician to provide information about their background, medical history, current medications, and ability to perform daily activities. In addition, the physician will need to take a blood sample and a sample of the tumor (which can come from a previous surgery or biopsy that the patient might have had). It takes about 20 working days to get each patient's test results.

"Not every patient will benefit from this test, but for some it could very well change their entire course of treatment and significantly prolong their life," says Jeff Boyd, PhD, executive director of the Cancer Genome Institute at Fox Chase. "At the very least, the results may help physicians decide how to treat their patients with advanced cancer -- whether by suggesting they use a particular type of drug or not use a particular type of drug or by allowing them to take part in clinical trials of new medications guided by their tumor's genetic profile."

To learn more about this new clinical test, please call 1-888-FOX CHASE or (1-888-369-2427).

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Cancer Genome Institute at Fox Chase among first to offer clinical blueprint of cancer genes

SAN FRANCISCO, Jan. 7, 2013 /PRNewswire/ --Second Genome announced today an initiative with the American Gut project to explore the connection between the human microbiome and type 2 diabetes. The cooperation will bring together American Gut's broad citizen science network for microbiome sample collection with Second Genome's efforts in identifying microbiome modulators and novel therapeutics. Second Genome has made an undisclosed donation to American Gut to subsidize specimen collection for participants with type 2 diabetes.

It is believed that the human microbiome plays an important role in the maintenance of good health, and that alterations to the balance of these microbial populations may have a negative impact on immunity and metabolism. American Gut has built the world's largest open-source, community driven effort to characterize the microbiomes of everyday people in order to understand the connections between environmental factors and microbiome changes.

"By working with the American Gut project and its preeminent group of microbiome scientists, we have the opportunity to accelerate the clinical impact of this citizen science effort to build the world's leading reference dataset of microbiomes," said Peter DiLaura, President and CEO of Second Genome. "Second Genome is focusing on patients with type 2 diabetes as one part of its effort to translate microbiome science into the discovery and development of microbiome modulators with therapeutic potential."

"Second Genome brings a special focus on tackling specific clinical questions, including the impact that changes in the human microbiome have in patients with type 2 diabetes," said Dr. Rob Knight, Associate Professor of Chemistry and Biochemistry at University of Colorado - Boulder and project lead for American Gut. "We are pleased to partner in this way with Second Genome and look forward to exciting new discoveries from this research."

About Second Genome

Second Genome brings microbiome science to the discovery and development of therapeutic products. The company has established a pipeline of microbiome modulators that impact infection, immunity and metabolic diseases. Second Genome's development pipeline is fueled by novel technologies for identifying, screening and scientifically validating product candidates and microbial biomarkers. Second Genome's technologies have been rigorously validated through partnerships with leading pharmaceutical and nutrition companies, as well as academic and governmental research institutions. Please visit http://www.secondgenome.com for more information.

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Second Genome Sponsors American Gut Initiative to Identify Links Between Type 2 Diabetes and the Human Microbiome

Whole-genome Testing and the Possibility of Gene Therapy for Neurological Disorders
(Visit: http://www.uctv.tv Soon everyone can have their genome sequenced. Will this information improve health, or simply clarify our fate? Series: "MIND Institute Lecture Series on Neurodevelopmental Disorders" [Health and Medicine] [Show ID: 24540]

By: UCtelevision

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Whole-genome Testing and the Possibility of Gene Therapy for Neurological Disorders - Video

AP Biology cvitale Evolution of Genomes.mp4
Table of Contents: 00:01 - GENOMES AND THEIR EVOLUTION 00:18 - GENOMICS 00:22 - BIOINFORMATICS 00:34 - HUMAN GENOME PROJECT 00:51 - 01:02 - COMPETING PROJECTS 01:23 - Three-Stage Approach to Genome Sequencing 01:30 - 01:54 - 03:43 - 05:29 - EXPRESSED SEQUENCE TAGS 06:02 - GENOME INTERACTIONS 06:09 - PROTEOMICS 06:17 - SYSTEMS BIOLOGY 06:38 - 06:53 - 07:00 - 07:16 - 07:36 - 07:49 - PSEUDOGENES 08:05 - REPETITIVE DNA 08:12 - TRANSPOSABLE ELEMENTS 11:01 - TRANSPOSONS AND RETROTRANSPOSONS 11:26 - TANDEMLY REPETITIVE DNA 11:46 - MULTIGENE FAMILIES 12:10 - 12:35 - 12:48 -

By: cvitale1015

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AP Biology cvitale Evolution of Genomes.mp4 - Video

WashU Browser: visualizing long-range genome interaction data (Updated)
Visualizing long-range genome interaction data with WashU Epigenome Browser Visit the Browser at: epigenomegateway.wustl.edu Narrated by Rebecca Lowdon Recorded using camStudio (camStudio.org)

By: Xin Zhou

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WashU Browser: visualizing long-range genome interaction data (Updated) - Video

Cancer Genome Institute TV Ad - January 2013

By: FoxChaseCancerCenter

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Cancer Genome Institute TV Ad - January 2013 - Video

Jan. 3, 2013 Researchers at MIT, the Broad Institute and Rockefeller University have developed a new technique for precisely altering the genomes of living cells by adding or deleting genes. The researchers say the technology could offer an easy-to-use, less-expensive way to engineer organisms that produce biofuels; to design animal models to study human disease; and to develop new therapies, among other potential applications.

To create their new genome-editing technique, the researchers modified a set of bacterial proteins that normally defend against viral invaders. Using this system, scientists can alter several genome sites simultaneously and can achieve much greater control over where new genes are inserted, says Feng Zhang, an assistant professor of brain and cognitive sciences at MIT and leader of the research team.

"Anything that requires engineering of an organism to put in new genes or to modify what's in the genome will be able to benefit from this," says Zhang, who is a core member of the Broad Institute and MIT's McGovern Institute for Brain Research.

Zhang and his colleagues describe the new technique in the Jan. 3 online edition of Science. Lead authors of the paper are graduate students Le Cong and Ann Ran.

Early efforts

The first genetically altered mice were created in the 1980s by adding small pieces of DNA to mouse embryonic cells. This method is now widely used to create transgenic mice for the study of human disease, but, because it inserts DNA randomly in the genome, researchers can't target the newly delivered genes to replace existing ones.

In recent years, scientists have sought more precise ways to edit the genome. One such method, known as homologous recombination, involves delivering a piece of DNA that includes the gene of interest flanked by sequences that match the genome region where the gene is to be inserted. However, this technique's success rate is very low because the natural recombination process is rare in normal cells.

More recently, biologists discovered that they could improve the efficiency of this process by adding enzymes called nucleases, which can cut DNA. Zinc fingers are commonly used to deliver the nuclease to a specific location, but zinc finger arrays can't target every possible sequence of DNA, limiting their usefulness. Furthermore, assembling the proteins is a labor-intensive and expensive process.

Complexes known as transcription activator-like effector nucleases (TALENs) can also cut the genome in specific locations, but these complexes can also be expensive and difficult to assemble.

Precise targeting

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Editing genome with high precision: New method to insert multiple genes in specific locations, delete defective genes

Re-design the Human Genome. Thanks to the Pentagone and the Industral Complex.

By: william ross

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Re-design the Human Genome. Thanks to the Pentagone and the Industral Complex. - Video

The Plan to Redesign the Human Genome
The pieces of the puzzle are coming together: the rise of social media, the Human Genome Project, DNA as an antenna for receiving/transmitting electromagnetic frequencies, genetically modified organisms (Monsanto), HAARP (High frequency Aurora Active Research Project), the worldwide spraying of chemtrails (aluminum, barium, nanoparticles), and the discovery that nanoparticles can act as transmitters.

By: metedude3

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The Plan to Redesign the Human Genome - Video

"To Redesign the Human Genome"
Source: SuperDeltaBravo1 http://www.youtube.com Human Genome Project Resources: http://www.kumc.edu Thoughts on eugenics and eugenicists: rense.com

By: irisphant

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"To Redesign the Human Genome" - Video