Category Archives: Genome

Shuang Wang - Genome Compression
iDASH Third Annual All Hands Symposium September 16-17, 2013 Atkinson Hall (Calit2) auditorium, University of California San Diego.

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Shuang Wang - Genome Compression - Video

Parts of human DNA that do not contain genes but instead turn them on and off may be just as vulnerable to cancer-causing mutations as protein-producing genes are, a new study finds.

Using computer programs to comb through the DNA of 88 cancer patients, researchers identified 98 mutations in gene-regulating parts of the genome that may be causing the patients breast, prostate or brain tumors, the team reports in the Oct. 4 Science.

The findings may help researchers better understand which genetic alterations lead to disease and which are harmless. It helps to clarify a confusing question in human variation: What variants are important? says Douglas Levine, a surgeon at Memorial Sloan-Kettering Cancer Center in New York City who was not involved with the work.

Finding one or a handful of variants that lead to disease is a daunting task because it requires sorting through more than 3 billion bases the information-carrying chemicals that make up DNA in each person. As a result, many scientists have narrowed their search to the 1 to 2 percent of the genome that makes proteins.

But many genetic variants implicated in common conditions such as diabetes and heart disease fall in the no-protein land between genes. Rare disease-causing mutations, such as those that spark cancer, may also fall in that vast, mysterious territory known as noncoding DNA.

"When it comes to cancer, those regions have been neglected so far," says Jan Korbel, a geneticist at the European Molecular Biology Laboratory in Heidelberg, Germany. Cancer researchers didn't have enough data to allow a search, says Korbel, who was not involved in the research. "This study shows how you can find these candidates."

To narrow down which noncoding parts probably contain important variants, Ekta Khurana, a computational biologist at Yale University, and her colleagues examined DNA from 1,092 volunteers in the 1000 Genomes Project, an effort to uncover human genetic variation. The team also used information from the Encyclopedia of DNA Elements, known as ENCODE. That project maps stretches of noncoding DNA that are important for switching genes on and off. Some switches control when one or a small number of genes turn on; others govern many genes.

To find the switches most likely related to disease, Khurana and colleagues reasoned that if a stretch of noncoding DNA were particularly important for health, natural selection would have weeded out variants. So the team looked for regions that contain fewer mutations than would be expected by chance. A mutation in one of those sensitive places is about 40 times as likely to cause disease as is a mutation elsewhere in the genome, the researchers found.

Even fewer mutations showed up in a small subset of those sensitive regions, indicating that those switches may be ultrasensitive to change. A mutation in one of these glass-jawed pieces of DNA is about 400 times as likely to cause disease as is one in an average stretch of DNA.

The team used these data to create a computer program that identifies mutations in noncoding parts of the genome and scores how detrimental changes are likely to be. The researchers then used the program to analyze the cancer patients DNA. Of 98 mutations the researchers identified, 90 damage hub controllers of gene syndicates and 68 fall in sensitive noncoding areas.

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Cancer variants found in 'neglected' region of genome

BroadE: Introduction to Genome STRiP for discovery and genotyping of deletions
Copyright Broad Institute, 2013. All rights reserved. The presentations below were filmed during the 2013 GATK Workshop, part of the BroadE Workshop series. ...

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BroadE: Introduction to Genome STRiP for discovery and genotyping of deletions - Video

Code For Life The Human Genome MultiScienceChannel

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Code For Life The Human Genome MultiScienceChannel - Video

Sasquatch Genome Project #39;s Dr. Melba Ketchum on ABC 8

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Sasquatch Genome Project's Dr. Melba Ketchum on ABC 8 - Video

The researchers of Sasquatch Genome Project led by Dr. Melba Ketchum has presented evidences of Bigfoot existence in Texas during a press conference. Some DNA samples and an HD video footage of the...

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The researchers of Sasquatch Genome Project led by Dr. Melba Ketchum has presented evidences of Bigfoot existence in Texas during a press conference. Some DNA samples and an HD video footage of the alleged Bigfoot sleeping in the Kentucky woods has been shown to media.

Sasquatch Genome Project team claims that these evidences proves that the Bigfoot is a human hybrid. Their $500,000 study now shows that the legendary Sasquatch creature "Bigfoot" exists in North America. This alleged creature was once human. Bigfoot was evolved from humans approximately 13,000 years ago.

The group of Sasquatch Genome Project researchers also claims that they have "111 specimens of Sasquatch hair, blood, skin and other tissue types," according to NYDailyNews. These specimens confirms that Bigfoot is real.

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Sasquatch Genome Project Finds Bigfoot

When it comes to believing in Bigfoot or Sasquatch, it seems like you are either a die hard believer or a complete skeptic. If you happened to be torn between believer and skeptic, you may want to consider the evidence brought force by the Sasquatch Genome Project researchers. This group of scientists recently released footage and DNA evidence that they said would prove the existence of Sasquatch.

The evidence was presented at a news conference held in Dallas on Tuesday. The researchers claim that they have been sequencing DNA from 3 different sasquatch genomes and have spent over 5 years on the project. The results of the study show that sasquatch is a human relative that arose approximately 13,000 years ago and is a hybrid cross between a primate and Homo sapiens.

While the three Sasquatch nuclear genomes aligned well with one another and showed significant homology to human chromosome 11, the Sasquatch genomes were novel and fell well outside of known ancient hominin as well as ape sequences, explains Melba Ketchum. Because some of the mtDNA haplogroups found in our Sasquatch samples originated as late as 13,000 years ago, we are hypothesizing that the Sasquatch are human hybrids, the result of males of an unknown hominin species crossing with female Homo sapiens.

While many people say their presentation is bologna, many other were excited to see the film evidence and believe it to be authentic. The team says they are not finished with their work and are still collecting evidence and working on DNA evidence. They plan to use the evidence to film a documentary in the near future.

Image from Wikimedia Commons.

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Sasquatch Genome Project Presents Evidence

Recurrent mutations in melanoma detected by genome sequencing
Drs. John M. Kirkwood and Antoni Ribas chaired the Perspectives in Melanoma XVII meeting on September 13-14, 2013 in Baltimore, Maryland. This webcast is composed of presentations from though...

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Recurrent mutations in melanoma detected by genome sequencing - Video

Jewish Genome Myth BUSTED! video below
Jewish Genome Myth BUSTED! video below.

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Jewish Genome Myth BUSTED! video below - Video

Bt Genome analysis

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Bt Genome analysis - Video