Category Archives: Genome

Zoom in on your genome - female

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Zoom in on your genome - female - Video

Zoom in on your genome - male

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Zoom in on your genome - male - Video

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
To watch this video on jove.com, click here: http://www.jove.com/video/3303?utm_source=youtube The Target ID Library is a plasmid-based, genome-wide collecti...

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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library - Video

Population Genetics of the Neanderthal Genome Project
Montgomery Slatkin, UC Berkeley Computation-Intensive Probabilistic and Statistical Methods for Large-Scale Population Genomics http://simons.berkeley.edu/ta...

By: Simons Institute

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Population Genetics of the Neanderthal Genome Project - Video

IBM and Mars use Deep Analytics to Map the Cocoa Genome 00 12
http://www.network-engineer.usa.cc/index.php http://www.network-engineer.usa.cc/feed/ http://www.ibm.com https://twitter.com/CharlyPrudent https://plus.goog...

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IBM and Mars use Deep Analytics to Map the Cocoa Genome 00 12 - Video

Whole genome re-sequencing reveals agronomically important loci in rice using MutMap and QTL-seq
4th International Workshop on Next Generation Genomics and Integrated Breeding for Crop Improvement February 19-21, 2014 Title: Whole genome re-sequencing re...

By: KSIconnect

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Whole genome re-sequencing reveals agronomically important loci in rice using MutMap and QTL-seq - Video

Any Way You Want It: Applications of Whole Genome Capture to Ancient DNA, Metagenomics, and...
Any Way You Want It: Applications of Whole Genome Capture to Ancient DNA, Metagenomics, and Orthogonal Validation Carlos Bustamante, Stanford University Comp...

By: Simons Institute

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Any Way You Want It: Applications of Whole Genome Capture to Ancient DNA, Metagenomics, and... - Video

CSHL Professor David J. Stewart, Ph.D. speaks at the CSHLA Genome Education Presentation
Professor Stewart gives a lecture to the CSHL Association. CSHL at the Crossroads of Genome Science. January 23, 2014.

By: ColdSpringHarborLab

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CSHL Professor David J. Stewart, Ph.D. speaks at the CSHLA Genome Education Presentation - Video

A study led by Dr. Roderic Guig from the Centre for Genomic Regulation in Barcelona, as part of the Chronic Lymphatic leukemia Genome Consortium, has made new advances in the study of this disease. The work, which was published (in print version) last week in the journal Genome Research, scrutinised the functional profile of the genes and mutations associated with leukemia.

The Spanish Chronic Lymphatic Leukemia Genome Consortium had previously identified the principal mutations involved in the development of the disease. However, its functional profile, the activity of these mutated genes, had not been studied. Now, the researchers have sequenced the functional part of the genome of the leukemia cells, the RNA, and several populations of healthy B lymphocytes from 98 patients.

The scientists found that there are thousands of genes that are expressed in a distinct way in leukemia cells in comparison to the healthy B lymphocytes, and that their functions are also very different. In particular, in the leukemia cells many genes are expressed relating to certain metabolic pathways that make them more active.

By observing these differences, the researchers have also clearly identified two subgroups of patients with different disease behaviour, making up one group of patients that do not need treatment for a long time, while others need it more quickly. In addition, they observed that the origin of these two subgroups could be found in the activating signals received by the leukemia cells in the lymph nodes. "Thanks to the functional study of the genome we have been able to identify two clear subgroups amongst patients and we have confirmed that the aggressiveness of the disease is different in the two groups. Understanding the molecular basis of these two subgroups will enable specific treatments to be established for each of them," says Dr. Guig.

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The above story is based on materials provided by Center for Genomic Regulation. Note: Materials may be edited for content and length.

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New advances in the chronic lymphocytic leukaemia genome

Send to genome II

By: nativus222

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Send to genome II - Video