Category Archives: Genome

Evolution Lesson 10 - DNA Human Genome (2)
One year study of Evolution DNA by Dr. Bo Kirkwood bokirkwood@ aol.com.

By: norrislong

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Evolution Lesson 10 - DNA & Human Genome (2) - Video

Could far-flung mutations in the genome activate cancer-causing genes?
A Perspective published with his postdocs, Hans-Martin Herz, Ph.D. and Deqing Hu, Ph.D., in the March 20th issue of Molecular Cell. In it, they summarize how...

By: Stowers Institute

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Could far-flung mutations in the genome activate cancer-causing genes? - Video

Genome: A healthcare revolution - Newsnight
Rohan Silva investigates the potential of the human genome in creating a personalised healthcare revolution Follow @BBCNewsnight on Twitter https://twitter.c...

By: BBC Newsnight

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Genome: A healthcare revolution - Newsnight - Video

IBM says it is joining a 'genomic medicine' initiative, using its Watson supercomputer to deliver customised treatment options for cancer patients.

The US computing group said on Wednesday it was teaming with the New York Genome Center in a program to help doctors develop treatments tailored to each patient's genetic makeup.

The first phase will help oncologists find treatments for patients with glioblastoma, an aggressive and malignant brain cancer that kills more than 13,000 people in the United States each year.

The supercomputer will be used to scan medical journals, new studies and clinical records and correlate those with a patient's genetic mutations.

'Clinicians lack the tools and time required to bring DNA-based treatment options to their patients,' said a statement from IBM and the Genome Center.

'This joint NYGC Watson initiative aims to speed up this complex process, identifying patterns in genome sequencing and medical data to unlock insights that will help clinicians bring the promise of genomic medicine to their patients.'

Because Watson can continually 'learn' from new data, the initiative aims to update databases that give doctors the best treatment options.

'Since the human genome was first mapped more than a decade ago, we've made tremendous progress in understanding the genetic drivers of disease,' said Robert Darnell, president and scientific director of the centre.

'The real challenge before us is how to make sense of massive quantities of genetic data and translate that information into better treatments for patients.

'Applying the cognitive computing power of Watson is going to revolutionise genomics and accelerate the opportunity to improve outcomes for patients with deadly diseases.'

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IBM's Watson helps genome research

INOKI GENOME FIGHT 1
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By: inokigenome

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INOKI GENOME FIGHT 1 - Video

Genome-Scale Sequence Analysis - Tyra Wolfsberg
March 19, 2014 - Current Topics in Genome Analysis 2014 A lecture series covering contemporary areas in genomics and bioinformatics. More: http://www.genome....

By: GenomeTV

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Genome-Scale Sequence Analysis - Tyra Wolfsberg - Video

Scientists Complete Largest Sequenced Genome Yet
Researchers sequenced the loblolly pine #39;s 22 billion base pairs, the largest sequenced genome yet. The human genome only has 3 billion base pairs. Follow Mik...

By: NewsyScience

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Scientists Complete Largest Sequenced Genome Yet - Video

[PPC Debut] [Orange Genome] [8]
Here is our debut song! We start with a story of unrequited love for someone who is in love with someone else. Leader comments : I am so sorry for any mistak...

By: Paka Paka Chorus

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[PPC Debut] [Orange Genome] [8] - Video

The massive genome sequence of the loblolly pine the most commercially important tree species in the United States and the source of most American paper products has been completed by a nationwide research team, led by a UC Davis scientist.

The draft genome approximately seven times bigger than the human genome is the largest genome sequenced to date and the most complete conifer genome sequence ever published. The sequencing was accomplished by using, for the first time, a faster and more efficient analytical process. The achievement is described in two papers in the March 2014 issue of GENETICS and in one paper in the open access journal Genome Biology.

The genome sequence will help scientists breed improved varieties of the loblolly pine, which also is being developed as a feedstock for biofuel. The newly sequenced genome also provides a better understanding of the evolution and diversity of plants.

Its a huge genome. But the challenge isnt just collecting all the sequence data. The problem is assembling that sequence into order, said David Neale, a professor of plant sciences at the University of California, Davis, who led the loblolly pine genome project and is an author on the GENETICS and Genome Biology articles.

To tackle the enormous size of the loblolly pines genome, which until recently has been an obstacle to sequencing efforts, the research team used a new method that can speed up genome assembly by compressing the raw sequence data 100-fold.

Modern genome sequencing methods make it relatively easy to read the individual letters in DNA, but only in short fragments. In the case of the loblolly, 16 billion separate fragments had to be fit back together a computational puzzle called genome assembly.

We were able to assemble the human genome, but that was close to the limit of our ability; seven times bigger was just too much, said Steven Salzberg, professor of medicine and biostatistics at Johns Hopkins University, one of the directors of the loblolly genome assembly team and an author on the papers.

The key to the solution was using a new method, developed by researchers at the University of Maryland, which pre-processes the sequence data, eliminates redundancies and yields 100 times less sequence data. This approach, tested for the first time in this study, allowed the team to assemble a much more complete genome sequence than the draft assemblies of two other conifer species reported last year.

The size of the pieces of consecutive sequence that we assembled are orders of magnitude larger than whats been previously published, said Neale, noting that the loblolly now provides a high-quality reference genome that considerably speeds along future conifer genome projects.

The loblolly genome research was conducted in an open-access manner, benefiting the research community even before the genome sequencing effort was completed and published. Data have been freely available throughout the project, with three public releases starting in June 2012.

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Loblolly pine's immense genome conquered

USDM Sti Genome
Quick video of my USDM sti genome exhaust with cat less downpipe Uploaded with iPhone.

By: Dominic Chao

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USDM Sti Genome - Video