Category Archives: Genome

IGF-1INOKI GENOME FIGHT 2014

By: PRIDE DREAM

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IGF-1INOKI GENOME FIGHT 2014 - Video

The Cancer Genome Atlas : Genomic Characteristics of Ovarian Cancer
A discussion of the results of a new study, part of The Cancer Genome Atlas (TCGA), to genomically characterize ovarian cancer, featuring Paul Spellman, Ph.D...

By: CancerVideoTV

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The Cancer Genome Atlas : Genomic Characteristics of Ovarian Cancer - Video

Kevin Davies Discusses The $1,000 Genome
ISHI24 Keynote Speaker, Kevin Davies, shares how his book, The $1000 Genome, came to fruition and what he foresees to be the future of genome sequencing.

By: Promega Corporation

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Kevin Davies Discusses The $1,000 Genome - Video

Trialomics Presentation

By: Genome Technology Access Center

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Trialomics Presentation - Video

Jewish Genome Exposed as Fraud
We at Ancestral Productions would like to see Yitzchak Ginsburgh #39;s own DNA analysis given his very public self-congratulatory remarks concerning the supposed...

By: Ancestral Productions

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Jewish Genome Exposed as Fraud - Video

Edico Genome has developed a circuit board card that plugs into computers to speed processing of genomic data.

A San Diego startup has come up with technology that it claims streamlines the mapping of next-generation DNA sequencing data into useful information.

Edico Genome has developed the Dragen Wavefront Processor system that can take data that might require 20 hours to process today and do it in less than 30 minutes, said Pieter van Rooyen, chief executive officer of the firm.

It makes things obviously a lot faster, but our biggest value proposition, I would say, is actually the cost, he said. It provides all the bio-IT processing at a much lower cost.

While the core cost of sequencing a human genome now has fallen below $1,000 thanks to new high-tech machines from San Diego-based Illumina and similar devices from Thermo Fishers Life Technologies unit in Carlsbad processing the enormous amounts of digital data created during DNA sequencing remains a time-consuming, computer-intensive bottleneck that is slowing down efforts to bring the full benefit of genomic medicine to the public.

According to van Rooyen, the company is talking with Illumina and Thermo Fisher about its technology. Illumina declined to comment. Mike Lelivelt, director of software products for Thermo Fishers Ion Torrent line of sequencers, said data sets are so large in next-generation sequencing that research labs have banks of computers sitting near sequencing machines to process the genetic information and hunt for variants.

What (Edico is) trying to do is speed up what could be a very time-intensive process by using a highly modified collection of graphic processors that are specifically built to do massively parallel mapping of these individual (sequencing) reads, he said.

The question is whether Edicos faster processing technology is worth the potential cost.

Van Rooyen claims Dragen Wavefront cuts costs by reducing computer hardware and other back-office infrastructure expenses. But Lelivelt isnt so sure of the savings. Edico sells an aftermarket circuit board card that plugs into computers. Installation, along with the costs of the processor itself, could make it too expensive for the benefit.

Do the people buying this value speed to the point where they are willing to pay the premium that might be coming in with this? asked Lelivelt.

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Edico Genome seeks to speed up DNA mapping

Anthony Donovan Jaan Patterson - Genome Chomsky (pt I)
Genome Chomsky (pt I) is a song by: Anthony Donovan Jaan Patterson from the album: Classwar Karaoke - 0025 Survey Release Date: February 28th, 2014 Label: ...

By: ccBestMusic

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Anthony Donovan & Jaan Patterson - Genome Chomsky (pt I) - Video

Highlights: John Duvick, Iowa State - xGDBvm Genome Annotation in the Cloud
These clips are taken from some of the presentations at the International Plant and Animal Genome Meeting XXIII, held in January 2014, in San Diego. iPlant u...

By: iPlant Collaborative

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Highlights: John Duvick, Iowa State - xGDBvm Genome Annotation in the Cloud - Video

CRISPR Genome Editing - Horizon Discovery
Horizon Discovery GENASSIST - CRISPR (clustered regularly interspaced short palindromic repeats) is a microbial #39;immune system #39; that has evolved to protect ...

By: GENESIS Gene-editing

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CRISPR Genome Editing - Horizon Discovery - Video

The spread of the antibiotic-resistant pathogen MRSA (methicillin-resistant Staphylococcus aureus) remains a concerning public health problem, especially among doctors trying to determine appropriate treatment options for infected patients. Bacterial pathogens, such as MRSA, cause disease in part due to toxicity, or the bacterium's ability to damage a host's tissue. In a study published online today in Genome Research, researchers used the genome sequence of MRSA to predict which isolates were highly toxic, thus potentially personalizing the treatment of individual MRSA infections.

To study MRSA's toxicity, "the standard approach has always been to focus on a single or small number of genes and proteins," said lead author Ruth Massey, from the University of Bath. However, this has not always been successful because toxicity is a complex trait encoded by many genetic loci.

In this new study, the authors used whole genome sequences from 90 MRSA isolates to identify over 100 genetic loci associated with toxicity. Despite belonging to the same ST239 clone, the isolates varied greatly in toxicity.

Importantly, the highly toxic isolates shared a common genetic signature. By looking for this signature in the MRSA genome, the researchers were able to predict which isolates were the most toxic and thus more likely to cause severe disease when used to infect mice.

"As the cost and speed of genome sequencing decreases, it is becoming increasingly feasible to sequence the genome of an infecting organism," said Massey. In a clinical setting, sequencing may be useful for deciding the course of MRSA treatment. For example, a clinician may treat a highly toxic infection more aggressively, including prescribing certain antibiotics known to reduce toxin expression. The patient also may be monitored more closely for complications and isolated from others to help control the spread of infection.

Although many novel genetic loci involved in MRSA toxicity were identified in this study, it remains to be determined how each influences disease. In addition to examining genomes of other MRSA strains, such as the particularly antibiotic-resistant USA300 strain, the authors are working to apply their methodology to other bacterial pathogens, such as Streptococcus pneumonia, a leading cause of deaths in infants and children under the age of five.

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The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.

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Genome sequencing of MRSA infection predicts disease severity