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Category Archives: Genetic Engineering
Explained: Who can take the Covid-19 vaccine, and who are advised not to – The Indian Express
Posted: January 29, 2021 at 11:38 am
Delay after hospitalisation
The Health Ministry on January 14 circulated a note on precautions and contraindications (reasons not to give the Covid-19 vaccine to certain people). The vaccine is only for people above the age of 18. Interchangeability is not allowed, which means that the second dose should be of the same vaccine (Covishield or Covaxin) that was given as the first dose. For acutely unwell or hospitalised patients due to any illness, vaccination can be deferred for four to eight weeks after recovery.
Not for pregnant women
Pregnancy alters the bodys immune system and its response to viral infections in general, which can occasionally be reflected in more severe symptoms. This holds true for Covid-19 as well. Pregnant or lactating women have not been part of any Covid-19 vaccine clinical trial, and so women who are pregnant or not sure of their pregnancy, as well as lactating women, should not receive the vaccine at this time, experts have said. This is also part of the Health Ministry advisory.
Those with weaker immunity
The Ministry has advised caution in vaccinating persons with a history of bleeding or coagulation disorder. A Bharat Biotech fact sheet says the vaccine is not advisable for persons with allergies, bleeding disorder or weaker immunity, or on medicine that affects the immune system. Dr Srinath Reddy, President, Public Health Foundation of India, said that for those with compromised immunity, I would say inactivated virus (Bharat Biotech vaccine) is safer but it is up to the treating doctor to decide.
Chronic illness no bar
Among those who are not contraindicated and can take the vaccine are persons with a previous SARS-CoV-2 infection, those with a history of chronic diseases and morbidities (cardiac, neurological, pulmonary, metabolic, renal, malignancies), or immunodeficiency HIV, and patients on immune suppression due to any condition. This was part of the advisory sent by Dr Manohar Agnani, Additional Secretary, Union Ministry of Health and Family Welfare, on January 14 to chief secretaries across states, mission directors and state immunisation directors.
Diabetics & the obese
Dr V S Chauhan, former director of International Centre for Genetic Engineering and Biotechnology (known for his efforts to develop a vaccine for malaria), said those with diabetes and obesity must be in the priority list. Anyone who is susceptible to allergies if they decide to take the vaccine have to be observed very carefully. However, for those people who are heavily immune-compromised, the vaccine does not really hurt them but the system for mounting antibodies responses would be slow, Dr Chauhan said.
Voluntary, but advisable
Individuals who have one or more co-morbid conditions can take the vaccine as they are at high risk, and their medication will not interfere with vaccine efficacy, said Dr Randeep Guleria, Director of AIIMS, during an audiovisual session on questions on the vaccine; the video has been posted on the Health Ministry website. Vaccination is voluntary but it is advisable to protect oneself and close contacts, Dr Guleria said. Over 28 lakh health workers have been vaccinated in India in 13 days.
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Explained: Who can take the Covid-19 vaccine, and who are advised not to - The Indian Express
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With bioengineered food labels showing up in stores, here’s what you should know about GMOs – Genetic Literacy Project
Posted: January 21, 2021 at 3:31 pm
While genetic engineering is the term typically used by scientists, you will start seeing the bioengineered label on some of the GMO foods we eat in the United States.
Humans have used traditional ways to modify crops and animals to suit their needs and tastes for more than 10,000 years. Cross-breeding, selective breeding and mutation breeding are examples of traditional ways to make these changes. These breeding methods often involve mixing all the genes from two different sources. They are used to create common crops like modern corn varieties and seedless watermelon.
Modern technology now allows scientists to use genetic engineering to take just a specific beneficial gene, like insect resistance or drought tolerance, and transfer it into a plant. The reasons for genetic modification today are similar to what they were thousands of years ago: higher crop yields, less crop loss, longer storage life, better appearance, better nutrition, or some combination of these traits.
Since GMO foods were introduced in the 1990s, research has shown that they are just as safe as non-GMO foods. Since then, the U.S. Food and Drug Administration (FDA), U.S. Environmental Protection Agency (EPA), and U.S. Department of Agriculture (USDA) have worked together to ensure that crops produced through genetic engineering are safe for people, animals, and the environment.
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Foodborne diseases kill thousands of Americans each year. Tracing food with genetically engineered spores could help. – The Counter
Posted: at 3:31 pm
Bhuyan said that his company has plans to win over both farmers and consumers, and that many industries have already signed on to use the technology.
The traction we have gained spans multiple countries and supply chains ranging from meat, dairy, cannabis, coffee, leafy greens, and a range of non-organic items, he said. Its unclear which companies Aanika is currently working with, as only a handful of partnershipsincluding a collaboration with the diamond company, De Beers Grouphave been disclosed publicly.
A normal food recall can affect a dozen farms, some of which were not actually responsible for the outbreak. Instead of recalling produce from all those growers, Aanikas spores could instead be used to pinpoint the outbreaks source, which would have the additional benefit of reducing the number of claims that an insurance company would have to pay out. This year, Aanika will work directly with agricultural insurers, offering them up to $10 million in guarantees, an incentive to protect insurers against loss in case claims submitted to them by farmers are not reduced as a result of using Aanikas spores. The move was made public in a blog post that the company posted to Medium in December, and it could offer enough of a financial incentive to get more large-scale traction with farmers.
As for consumer concerns, Bhuyan said that, even if spores did end up on your dinner plate, the average person poops out thousands of bacterial spores every daya claim supported by a recent studyso we dont think this will be a problem.
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Livestock Producers on Level Playing Field Thanks to MOU Between USDA and FDA – Pork Magazine
Posted: at 3:31 pm
A Memorandum of Understanding (MOU) has been finalized regarding regulation of certain animals developed using genetic engineering. USDA announced the MOU with the Food and Drug Administration that outlines responsibilities regarding genetically engineered animals that are intended for agricultural purposes such as human food, fiber and labor.
This MOU complements USDAs issuance of an Advanced Notice of Proposed Rulemaking (ANPR) on the Movement of Animals Modified or Developed by Genetic Engineering on December 28, 2020.
Todays Memorandum of Understanding clears a path to bring our regulatory framework into the 21st century, putting American producers on a level playing field with their competitors around the world. In the past, regulations stifled innovation, causing American businesses to play catch-up and cede market share, said U.S. Secretary of Agriculture Sonny Perdue in a release. America has the safest and most affordable food supply in the entire world thanks to the innovation of our farmers, ranchers and producers. Establishing a new, transparent, risk and science-based regulatory framework would ensure this continues to be the case.
The terms of the MOU support USDAs ANPR outlining a contemplated regulatory framework that would apply to certain animals (cattle, sheep, goats, swine, horses, mules, or other equines, catfish, and poultry) developed using genetic engineering intended for agricultural purposes, USDA explains. Under this framework, USDA would safeguard animal and human health by overseeing pre-market reviews through post-market food safety monitoring for certain farm animals modified or developed using genetic engineering that are intended for human food.
The National Pork Producers Council (NPPC) applauded the MOU signed between the USDA and the FDA, giving USDA primary regulatory jurisdiction over the development of gene-edited livestock.
NPPC has been calling for this decision for more than three years to ensure that U.S. agriculture maintains its competitive edge globally. We look forward to working with the Biden administration to implement a technology that has the potential to improve animal health, further reduce agricultures environmental footprint and improve production efficiency, NPPC said in a statement.
The MOU also allows for the transition of portions of FDAs pre-existing animal biotechnology regulatory oversight to USDA. USDA would continue to coordinate closely with FDA to fulfill oversight responsibilities and provide the appropriate regulatory environment, ensuring the safety of products derived from new technologies and fostering innovation at the same time, the release said.
FDA would continue its review of intentional genomic alterations intended for any purpose other than agricultural use, such as biopharma and non-heritable genomic alteration, and the regulation of dairy products, table and shell eggs, certain meat products and animal feed derived from animals developed using genetic engineering.
Read More:
FDA Stalls U.S. Gene-Edited Livestock Efforts
USDA Oversight of Gene-Edited Livestock: A Seismic Shift for Agriculture
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Livestock Producers on Level Playing Field Thanks to MOU Between USDA and FDA - Pork Magazine
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Advarra Announces New Gene Therapy Ready Site Network – PRNewswire
Posted: at 3:31 pm
This will address an accelerating gene therapy market that is expected to grow globally by 16.6 percent from 2020-2027.
"The Gene Therapy Ready network demonstrates our commitment to empowering sites and supporting our industry partners as they pursue advanced genetic engineering to find cures for the world's most pressing health conditions," said Scott Uebele, President and Chief Research Services Officer at Advarra. "Our commitment to efficient study activation is unwavering, and this is another example of how Advarra bringslife sciences companies,CROs, research sites, investigators,andacademiatogether at the intersection of safety,compliance,technology, and collaboration."
All Gene Therapy Ready sites stand ready to help industry sponsors conduct clinical trials that advance cures, develop vaccines, and find treatments for rare disease. By placing clinical trials with a Gene Therapy Ready site, research sponsors can save significant time during study startup.
"This innovative network is truly the first of its kind. We constantly look for ways to support our sponsors in rapidly starting trials in a safe, compliant, and quality manner. With the Gene Therapy Ready network, we can improve study startup times by a month or more, potentially placing cures in the hands of patients faster," said James Riddle, Vice President of Research Services and Strategic Consulting at Advarra. "The Gene Therapy Ready site network charts a course to success by providing our sponsor clients with a clear choice for IBC review services."
About Advarra
Advarra advances the way clinical research is conducted: bringing life sciences companies, CROs, research sites, investigators, and academia together at the intersection of safety, technology, and collaboration. With trusted IRB and IBC review solutions, innovative technologies, experienced consultants, and deep-seated connections across the industry, Advarra provides integrated solutions that safeguard trial participants, empower clinical sites, ensure compliance, and optimize research performance. Advarra is advancing clinical trials to make them safer, smarter, and faster. For more information, visit advarra.com.
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Advarra Announces New Gene Therapy Ready Site Network - PRNewswire
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Designer baby book trilogy explores the moral dilemmas humans may soon create – Big Think
Posted: at 3:31 pm
Imagine it's 2045. You start hearing rumors from your well-heeled friends about a mysterious corporation based on an undisclosed island that's offering an unprecedented service: the ability to genetically design your baby.
The baby will have some of your genetics, and some genetics from a sperm or egg donor, selected by you. But the rest of your child's genetic profile will be engineered by science. These changes will make it impossible for your child to develop genetic diseases. They'll also allow you to customize your child for dozens of traits, including intelligence level, emotional disposition, sexual orientation, height, skin tone, hair color, and eye color, to name a few.
This raises unsettling philosophical questions for some customers. "When does my child stop being my child?" they ask the corporate representatives. These wary customers are reminded of how risky it is to reproduce the old-fashioned way. The Better Genetics Corporation's motto sums it up: "Only God plays dicehumans don't have to."
This is the world described in a new science-fiction series by Eugene Clark titled "Genetic Pressure", which explores the moral and scientific implications of a future in which designer babies are becoming a major industry. The first book begins with the story of Rachel, a renowned horse breeder who befriends a billionaire client, and soon gets the funding to visit the tropical island on which the Better Genetics Corporation is headquartered.
There, corporate executives walk her through the process of designing a babyan experience that feels like an uncanny mix between visiting a doctor and designing a luxury car. The series is told from multiple perspectives, serving as a deep dive into a complex moral web that today's scientists may already be weaving.
Case in point: In 2018, Chinese scientist He Jiankui announced that he had helped create the world's first genetically engineered babies. Using the gene-editing tool CRISPR on embryos, He Jiankui modified a gene called CCR5, which enables HIV to enter and infect immune system cells. His goal was to engineer children that were immune to the virus.
It's unclear whether he succeeded. But what's certain is that the experiment shocked the international scientific community, which generally agreed that it's unethical to conduct gene-editing procedures on humans, given that scientists don't yet fully understand the consequences.
"This experiment is monstrous," Julian Savulescu, a professor of practical ethics at the University of Oxford, told The Guardian. "The embryos were healthy. No known diseases. Gene editing itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life, including the development of cancer."
Importantly, He Jiankui wasn't treating a disease, but rather genetically engineering babies to prevent the future contraction of a virus. These kinds of changes are heritable, meaning the experiment could have major downstream effects on future generations. So, too, would a designer-baby industry, even if scientists can do it safely.
With major implications on inequality, discrimination, sexuality, and our conceptions of life, the introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore.
One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groupsas it does in the series.
"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."
For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"they call her "soulless" and say she was "made in a factory," a "consumer product."
Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with.
Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate?
Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.
But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.
But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image.
When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc.
Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.
"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.
But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme.
On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.
In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, " three generations of imbeciles are enough."
After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations into the 1970s). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century.
Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it illegal to implant a genetically modified embryo. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies.
But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits.
If the industry did that, it'd effectively signal that the opposites of those traits are undesirable. As the International Bioethics Committee wrote, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."
"Genetic Pressure Volume I: Baby Steps" by Eugene Clark is available now.
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Designer baby book trilogy explores the moral dilemmas humans may soon create - Big Think
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Risk assessment of GE plants in the EU: Taking a look at the ‘dark side of the moon’ EUbusiness.com | EU news, business and politics – EUbusiness
Posted: at 3:31 pm
21 January 2021by testbiotech-- last modified 21 January 2021
Testbiotech has published a new report providing evidence that the European Food Safety Authority (EFSA) is intentionally keeping significant risks related to genetically engineered (GE) plants 'in the dark'.
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While EFSA is aware that the data compiled by industry are insufficient to demonstrate the safety of the plants, it has nevertheless failed to take action to solve the problems. On the contrary, the authority has for years defended assumptions even if they are in contradiction to the facts. In addition, EFSA is intentionally trying to distract awareness away from the 'dark' sides of its risk assessment.
During the first 20 years of its existence, EFSA published more than 100 opinions on the risk assessment of GE crops, but was nevertheless unable to present sufficiently robust criteria and methods. The report published today reveals major gaps in risk assessment which can no longer be disputed. Moreover, the report also shows that specific areas of risk assessment are intentionally ignored .
"We need science more than ever to stop dangers such as climate change and pandemics. Science also has to be impartial, transparent and reliable when it comes to assessment of risky technologies and their profitable products. However, in the case of genetically engineered plants, the trade interests of industry are given priority when it comes to decision-making in the face of uncertainties," Christoph Then states for Testbiotech, an institute which is independent of the interests of biotech industry. Testbiotech has for more than ten years analysed the risks of genetically engineered organisms with a view to protecting health and the environment.
Testbiotech is accusing EFSA of a systematic failure to request sufficiently reliable data from industry. These problems concern, for example, field trials with genetically engineered herbicide-resistant plants that are sprayed with much lower rates of herbicide applications compared to current agricultural practice. Furthermore, the regions in which the field trials are carried out do not represent the bioclimatic conditions under which the GE plants are to be cultivated.
For the assessment of insecticidal Bt toxins produced in the plants, EFSA accepts experiments with toxins produced by bacteria. However, it is known that the toxins produced in the plants must be assumed to be much more toxic since plant constituents can multiply their toxicity. Furthermore, most of the approved GE plants carry a combination of (several) Bt toxins and (several) herbicide resistances. Nevertheless, EFSA does not request any empirical data on mixed toxicity or immunogenicity of the compounds present in the harvest.
At the same time, in regard to the potential spread of GE plants, EFSA makes assumptions that are outdated and therefore underestimates the actual risks. From a legal point of view, it also seems to be questionable that EFSA, in a self-assigned task, adopted a new guidance in 2015 allowing it to evade legally binding EU Commission standards in field trial assessments.
In conclusion, evidence has been provided to show that the genetic engineering of food plants has layers of complexity that go far beyond what can be assessed by current standards of risk assessment. The safety of the plants is claimed on basis of approval processes that only consider risks that are easiest to assess.
The Testbiotech analysis of the work of EFSA is also based on the outcomes of the RAGES (Risk Assessment of genetically engineered organisms in the EU and Switzerland) project. The RAGES project started in 2016 and ended in 2020; the outcomes were subsequently assessed by EFSA in June 2020.
Testbiotech is now urging the EU Commission to take action because the political responsibility for setting the standards in the risk assessment of GE organisms lies with the Commission.
What are the consequences of genetic engineering for humans and the environment? From a critical point of view, Testbiotech provides information and scientific expertise on the risks associated with these technologies, that is completely independent of the biotech industry.
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New computational method detects disrupted pathways in cancer – UB Now: News and views for UB faculty and staff – University at Buffalo Reporter
Posted: at 3:31 pm
Cancer is a notoriously complex disease, in part because it may be caused by mutations among hundreds or even thousands of genes. In addition, most cancers exhibit an extraordinary amount of variation among genetic mutations, even between patients with the same types of cancers.
Consequently, cancer researchers have chosen to study interactions among groups of genes in certain biological pathways that are disrupted.
When genes in certain pathways are frequently mutated or disrupted, that pathway may play a critical role in the initiation or development of cancer. But unraveling the molecular mechanisms underlying those disruptions is extremely complex.
Now, UB researchers have developed a new, statistically more powerful method called FDRnet that can more effectively detect key functional pathways in cancer using genomics data generated by next-generation sequencing technology.
Published in Nature Computational Science on Jan. 14, the new method has the potential to give biologists more precise data with which to zero in on therapeutic targets.
Using the new method, we can find biological pathways in which genes are significantly mutated or disrupted, explains Yijun Sun, associate professor of bioinformatics in the Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences at UB and the corresponding author. It addresses some key challenges in molecular pathway analysis in cancer studies. Once the tumor biologists obtain this information, they can use it to verify our findings, and from there develop new cancer treatments.
By overcoming the limitations of existing approaches, FDRnet can facilitate the detection of key functional pathways in cancer and other genetic diseases, he says.
When Sun and his co-authors tested FDRnet on simulation data and on breast cancer and B-cell lymphoma data, they found that FDRnet was able to detect which subnetworks or pathways are significantly perturbed in these cancers, potentially leading tumor biologists to identify new therapeutic targets.
Co-authors with Sun are Le Yang and Runpu Chen, both doctoral students in the Department of Computer Science and Engineering, School of Engineering and Applied Sciences, and Steven Goodison of the Department of Health Sciences Research at the Mayo Clinic.
The research was funded by the National Institutes of Health.
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Some Citrus Fruits Are In Danger. Here’s How Scientists Are Working To Save Them – WVXU
Posted: at 3:31 pm
Oranges and grapefruit are under siege in California. Growers are under pressure to protect all citrus varieties from an increasing threat that's already hit Florida.
Citrus Greening Disease, or HLB, was detected in Florida more than 10 years ago. Researchers are still trying to figure out how to protect the fruit from a disease with no effective commercial treatment.
Now HLB is in California. It has been detected in 2,000 trees but not yet in commercial orchards.
But there is hope on the horizon. University of California Riverside (UCR) researchers and their partners are perfecting a fruit that may be resistant to the greening disease.
Through genetic engineering, UCR scientists like Mikeal Roose is crossing U.S. varieties with Australian ones. A fruit down under similar to a lemon or lime, seems to have some resistance. Roose is crossing the U.S. variety with an Australian one and then again with an American citrus fruit.
"It's still a little bit difficult but it's doable," he says.
UCR has a $4.67 million grant from the National Institute of Food and Agriculture and is partnering with Texas A&M, the University of Florida, Washington State University and the U.S. Department of Agriculture.
UCR's Chandrka Ramadugu is leading the project. Eight years ago she was in Florida testing microcitrus varieties that had some natural resistance. "The goal is to have plants that have proven to be similar to citrus, that's acceptable by the public, but also to have part of the Australian citrus genome so it will be resistant to the disease," she says.
The challenge is to get the fruit to also taste good. This all takes time, maybe four to five years as all the crossbreeding takes place and is grown in different places and environments.
Scientists are also altering the soil to see if that could provide some immunity.
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Some Citrus Fruits Are In Danger. Here's How Scientists Are Working To Save Them - WVXU
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Global CRISPR Gene-Editing Market Analysis With Key Players, Applications, Trends And Forecasts 2028 – KSU | The Sentinel Newspaper
Posted: January 15, 2021 at 2:28 pm
DBMR has added a new report titled Global CRISPR Gene-Editing Market with analysis provides the insights which bring marketplace clearly into the focus and thus help organizations make better decisions. The Global CRISPR Gene-Editing Market research report offers the market insights from the statistics, gathered from the reliable market information such as manufacturers, channel partners, decision-makers and regulatory bodies. It outlines segment of the market investigates progression such as drivers, limitations and opportunities that at present strongly affect the market and could impact the market in future, Market share analysis mentioned in this report with a specific end goal to clarify the intensity of rivalry between driving market players working over the globe. It validated primary and secondary research methodology and data sources that are implied to collect key information like market size, trends, revenue and analysis.
The main objective of this Global CRISPR Gene-Editing Market report is to analyze the opportunities, threats and market drivers. Key insights like competitive industry scenario, gross margin analysis, price structure and cost analysis. It correctly calculates the global market share of important sections, regions and businesses. This research report examines the international market on the business plan based on numerous business verticals.
Global CRISPR gene-editing market is rising gradually with a healthy CAGR of 23.35 % in the forecast period of 2019-2026. Growing prevalence of cancer worldwide and expanding the application of CRISPR technology by innovative research from the different academic organizations are the key factors for market growth.
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Few of the major competitors currently working in the global CRISPR gene-editing market are Applied StemCell, ACEA BIO, Synthego, Thermo Fisher Scientific Inc, GenScript, Addgene, Merck KGaA, Intellia Therapeutics, Inc, Cellectis, Precision Biosciences, Caribou Biosciences, Inc, Transposagen Biopharmaceuticals, Inc, OriGene Technologies, Inc, Novartis AG, New England Biolabs among others
Global CRISPR Gene-Editing Market By Therapeutic Application (Oncology, Autoimmune/Inflammatory), Application (Genome Engineering, Disease Models, Functional Genomics and Others), Technology (CRISPR/Cas9, Zinc Finger Nucleases and Others), Services (Design Tools, Plasmid and Vector, Cas9 and g-RNA, Delivery System Products and Others), Products (GenCrispr/Cas9 kits, GenCrispr Cas9 Antibodies, GenCrispr Cas9 Enzymes and Others), End-Users (Biotechnology & Pharmaceutical Companies, Academic & Government Research Institutes, Contract Research Organizations and Others), Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa) Industry Trends and Forecast to 2026
Market Drivers
Market Restraints
Some of the Major Highlights of TOC covers:
Chapter 1: Methodology & Scope
Definition and forecast parameters
Methodology and forecast parameters
Data Sources
Chapter 2: Executive Summary
Business trends
Regional trends
Product trends
End-use trends
Chapter 3: CRISPR Gene-Editing Industry Insights
Industry segmentation
Industry landscape
Vendor matrix
Technological and innovation landscape
Chapter 4: CRISPR Gene-Editing Market, By Region
Chapter 5: Company Profile
Business Overview
Financial Data
Product Landscape
Strategic Outlook
SWOT Analysis
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Key Developments in the Market:
In April 2019, GenScript has launched Single-stranded DNA Service for CRISPR-based Gene Editing which help the key researchers to have access on the high quality, pure ssDNA for CRISPR-based gene insertion and hence can accelerate the development of gene as well as cell therapy for cancer immunotherapy
In February 2018, Cellectis has received two U.S. patents (US#9,855,297 and US#9,890,393) entiled as Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system for CRISPR Use in T-Cells. The U.S. grant of these patents, the company can generate revenue by out-licensing the products to the pharma companies that are ready to use CRISPR technologies in T-cells
Competitive Analysis:
Global CRISPR gene-editing market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of CRISPR gene-editing market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.
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Global CRISPR Gene-Editing Market Analysis With Key Players, Applications, Trends And Forecasts 2028 - KSU | The Sentinel Newspaper
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