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Category Archives: Genetic Engineering
8 ways business managers can use fiction to prepare for the uncertain reality of coronavirus – The Conversation CA
Posted: February 27, 2021 at 3:22 am
Reading fiction has always been, for many, a source of pleasure and a means to be transported to other worlds. But thats not all. Businesses can use novels to consider possible future scenarios, study sensitive workplace issues, develop future plans and avoid unplanned problematic events all without requiring a substantial budget.
During the COVID-19 pandemic, many business leaders have learned how important it is for businesses to consider a wide range of possible outcomes and to enhance organizational adaptability. Relying on analyzing or projecting trends and extending what business leaders usually do is no longer enough to assure future success. When management is poorly prepared for the unexpected, businesses start getting into trouble.
Scenario planning, therefore, helps businesses keep themselves flexible and move quickly with market shifts. Scenario planning is a series of potential stories or possible alternate futures in which todays decisions may play out. Such planning can help managers assess how they or their employees should respond in different potential situations.
Unfortunately, scenario planning requires time and resources. And depending on its use, such as for an investigation, budgeting or legal matters, it can also require collecting sensitive data. That can include employees personal experiences of sexual, discriminatory or psychological harassment, suicide, mental health, drug abuse, etc.
The more sensitive the needed data is, the more difficult it is to collect while ensuring employee privacy. This is where literary texts come in.
As sources for possible future scenarios capable of providing strategic foresight, or producing alternative future plans, novels can also help businesses create dialogue on difficult and even taboo subjects.
Novels are, therefore, capable of helping managers become better, providing them with creative insight and wisdom. Science fiction can provide a means to explore morality tales, a warning of possible futures, in an attempt to help us avoid or rectify that future.
Our research uses Aldous Huxleys 1932 novel Brave New World to explore possible scenarios related to situations that are usually kept confidential, such as employees mental health issues and drug use or abuse. We examined how employers encounter uncertainty around the impact that legalizing cannabis could have on the work environment, and ways to consider such potential effects.
Brave New World is set in a dystopian future and has been adapted numerous times, most recently into a 2020 TV series. It portrays a dystopic civilization whose members are shaped by genetic engineering and behavioural conditioning. Their happiness is maintained by government-sanctioned drug consumption. It is a world where countries are protected by walls that keep the undesired away an eerily familiar scenario to Donald Trumps promise of building a wall on the U.S.-Mexico border.
By reading the novel, business managers can compare the world we live in today and the path our countries and corporations are on to the fictional events in the novel. This can help them pay attention to and address less comfortable, and sometimes often neglected, sensitive workplace issues that need to be considered when planning for the future.
For example, in Brave New World, the consumption of the drug soma becomes the norm upon which life is founded. When soma is taken away, individuals can no longer face their reality and they end up welcoming death.
Brave New World offers workplace leaders a look at what could happen if employees wellness, mental health or drug use are disregarded, and lead to isolation, absence, resignation or, in dire circumstances, suicide.
To study sensitive workplace issues that could help generate new knowledge, lead to envisioning ways to act appropriately and develop future strategies, business managers can follow these steps:
Form a team of managers and an HR representative who is aware of company policies and ethics protocols, and is in direct contact with employees.
The team then decides which workplace issue(s) the organization needs to study.
The team chooses a literary text, such as a novel, that discusses those issues.
Each member of the team reads the literary text on their own before discussing it together in at least one session.
The team researches the chosen workplace topics inside the organization and outside (for example, laws and regulations related to each issue).
The team identifies insightful sections.
The team analyzes the chosen extracts.
The team writes a report with recommendations on workplace conditions and how best to improve them.
Reading has surged during lockdown. But literary works can provide us with more than a leisurely pastime. For businesses, novels represent a legitimate way to study the workplace, and this is accomplished by comparing the path our countries and corporations are on today to fictional events.
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8 ways business managers can use fiction to prepare for the uncertain reality of coronavirus - The Conversation CA
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Gene editing: Should livestock and crops be genetically engineered in the UK? – BBC Focus Magazine
Posted: February 6, 2021 at 8:08 am
In early January 2021, a consultation was launched that asks whether organisms produced by genetic engineering should continue to be classified as genetically modified, if the organisms could have been developed using traditional breeding methods.
The consultation is especially focused on gene editing, also known as genome editing, a technology that allows scientists to add, remove or alter an organisms DNA.
Unlike older types of transgenic genetic modification, this process doesnt introduce foreign DNA into the gene. In a speech launching the consultation, Environment Secretary George Eustice said gene editing raises far fewer ethical or biological concerns than transgenic modification and respects the rules of nature.
In 2018, the European Court of Justice ruled that gene-edited crops should be considered the same as other genetically modified crops under EU law, a ruling Eustice called flawed and stifling to scientific progress.
Prime Minister Boris Johnson shares a similar view. In 2019 he pledged to liberate the UKs extraordinary bioscience sector from anti-genetic-modification rules.
Read more about gene editing:
Gene editing is a relatively new and fast-evolving technology. The first type of gene editing, using CRISPR/Cas9, was only developed in 2012 (the two women that developed it won the 2020 Nobel Prize in Chemistry).
Views on regulating the use of gene editing in producing genetically modified animals or crops have generally fallen into two camps, says Prof Katherine Denby from the University of York, who works on new ways to improve crops using tools such as gene editing.
The first camp argues that as gene-edited crops or livestock could have arisen through traditional breeding processes, they should not be classed as genetically modified organisms, meaning they wouldnt be subject to genetic modification regulations.
The second camp holds that any organism made through gene editing should be regulated as a genetically modified organism, regardless of whether the final product could have been made using traditional breeding. Countries such as the US, Australia and Japan have taken the former, more relaxed, approach, while the EU has taken the latter, more stringent one.
Current UK regulations mean gene-edited crops can technically come to market, but the regulatory process is both lengthy and extremely costly, says Denby.
Its really prohibiting the development of products, both crops and genome-edited livestock, just because of that cost, she says. This, in turn, is prohibiting the development of traits that are for public good, such as disease resistance, she says.
Gene editing could potentially offer greater food security for the UK, but are there unseen dangers? Getty Images
For example, her own work aims to replicate the disease resistance found in older and wild relatives of lettuce in more modern varieties, a process that will go many times faster using gene editing rather than traditional breeding.
But other scientists are more sceptical about the benefits that gene editing can bring and are concerned about its potential dangers.
This technology comes with innate risks to alter the genetic composition, the patterns of gene function, says Dr Michael Antoniou, head of the gene expression and therapy group at Kings College London. In doing so you change the plants biochemistry.
Antoniou says gene editing is not as highly precise as is often claimed and can bring about unintended mutations. Worryingly, those who are developing gene-edited crops and foods are ignoring the risks, he says.
For instance, gene editing could run the risk of producing novel toxins or allergens, or increasing the levels of pre-existing toxins and allergens, especially in plants, he says.
Without strict safety checks, its possible that crops that are potentially harmful could enter the marketplace unlabelled and would therefore also be difficult to trace if any adverse outcomes were to be found, he adds.
In Antonious view, gene editing is unquestionably a genetic modification procedure and should continue being regulated in the UK as it is in the EU.
But many scientists argue that gene editing is crucial to supporting a more sustainable food system.
Genome editing is already used in medicine and has immense potential for tackling major agricultural challenges related to food security, climate change and sustainability, says Prof Denis Murphy from the University of South Wales.
Read more fromReality Check:
Denby agrees and says gene editing can play a part in making the UKs food system more sustainable, healthy and affordable, while admitting its not going to be a magic bullet.
But for Antoniou the focus really needs to be on the agricultural system as a whole, rather than improving individual crops and seeds.
Gareth Morgan, head of farming and land use policy at the Soil Association, has called gene editing a sticking plaster that diverts vital investment and attention from other more effective solutions.
The focus needs to be on how to restore exhausted soils, improve diversity in cropping, integrate livestock into rotations and reduce dependence on synthetic nitrogen and pesticides, he says. We want to see immediate progress in these areas rather than using Brexit to pursue a deregulatory agenda for genetic modification.
Visit the BBCs Reality Check website at bit.ly/reality_check_ or follow them on Twitter@BBCRealityCheck
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Gene editing: Should livestock and crops be genetically engineered in the UK? - BBC Focus Magazine
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Genomics and genre – Science
Posted: at 8:08 am
If the double helix is an icon of the modern age, then the genome is one of the last grand narratives of modernity, writes Lara Choksey in her new book, Narrative in the Age of the Genome. Hybridizing literary criticism with a genre-spanning consideration of a dozen distinct literary works, and imbued throughout with deep concern for the peripheral, the possible, and the political, the book seeks to challenge the whole imaginative apparatus for constructing the self into a coherent narrative, via the lexicon and syntax of the molecular.
To a reading of Richard Dawkins's The Selfish Gene (1976) as a repudiation of class struggle and E. O. Wilson's Sociobiology (1975) as a defense of warfare, Choksey juxtaposes another kind of ambiguous heterotopia in which genetic engineering is a tool of neoliberal self-fashioning. In Samuel R. Delany's Trouble on Triton (1976), Bron, a transgender ex-gigolo turned informatics expert, is caught between sociobiology and the selfish gene, between the liberal developmentalism of progressive evolution, and the neoliberal extraction and rearrangement of biological information. Even the undulating interruptions and parentheticals of Bron's thoughts [mimic] the description of the activation and silencing of genes, she suggests, tying together gene and genre in a way that encapsulates neoliberal alienation.
Choksey next explores the ways in which collectivist fantasies of biological reinvention under Soviet Lysenkoism fused code and cultivation through a close reading of Arkady and Boris Strugatsky's Roadside Picnic (1972) in which cultivated utopian dreamworlds become contaminated by alien forces, resulting in fundamental ecological transformations beyond the promised reach of human control. The novel brings to light not forgotten Soviet utopias but literal zombies and mutations. In a world where planned cultivation fails entirely in the face of the unfamiliar, even as new biological weapons are being developed, Earth itself viscerally reflects a fractured reality of lost promisesa world in crisis with all meaning gone, and survival itself a chancy proposition.
Framed as a family history, The Immortal Life of Henrietta Lacks is actually a horror story, argues Choksey.
As the promise of precision medicine emerged, so too did new forms of memoir. In Kazuo Ishiguro's Never Let Me Go (2005) and the film Gattaca (1997), for example, the traditional aspirational narrative of a pilgrim's progress is subverted: As the unitary subject disappears into data, algorithms, and commodities, a new grammar of existence emerges, albeit one in which the inherited problems of the pastracism, ableism, and the fiction of heteronormativityremain ever-present.
In Saidiya Hartman's Lose Your Mother (2006) and Yaa Gyasi's Homegoing (2016), Choksey sees a reorientation of genomics away from the reduction of self to code and toward new forms of kinship and belonging that offer a reckoning with the histories of brutalization and displacement upon which liberal humanism is founded. Even as genomics seeks to locate the trauma of enslavement at the level of the molecular, communities seeking reunion and reparation know that technology alone cannot do the cultural work of caring for history that narrative can offer.
Reading Rebecca Skloot's The Immortal Life of Henrietta Lacks (2010) as a biography of Black horror which tries, time and again, to resolve itself as family romance, Choksey identifies the perils of narratives unable to recognize their own genre. She argues that by blurring the lines not between fact and fiction but between horror and family history, the dehumanization of Black lives as experimental biomatter echoes inescapably with larger histories of the extraction of Black flesh for the expansion of colonial-capitalist production.
What emerges as most compelling out of this entire tapestry of readings is the author's interpretation of the limits and failures of the extraordinary cultural power of the genome. Concluding that genomics has privileged a particular conception of the human that is in the process of being reconfigured, Choksey ventures that the uncomplicated subject, the Vitruvian Man of the Human Genome Project, has reached its end. What is left is neither dust, stardust, nor a face erased in the sand (as Foucault would have it) but rather whatever might emerge next from the unwieldy kaleidoscope of possible meanings.
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Genomics and genre - Science
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Berkeley Lab Celebrates 90th Anniversary, Imagines the Next 90 Years | Berkeley Lab – Lawrence Berkeley National Laboratory
Posted: at 8:08 am
Ninety years ago, in August of 1931, physics professor Ernest Lawrence created the Radiation Laboratory in a modest building on the UC Berkeley campus to house his cyclotron, a particle accelerator that ushered in a new era in the study of subatomic particles. The invention of the cyclotron would go on to win Lawrence the 1939 Nobel Prize in physics.
From this start, Lawrences unique approach of bringing together multidisciplinary teams, world-class research facilities, and bold discovery science has fueled nine decades of pioneering research at the Department of Energys Lawrence Berkeley National Laboratory (Berkeley Lab). His team science approach also grew into todays national laboratory system.
Over the years, as Berkeley Labs mission expanded to cover a remarkable range of science, this approach has delivered countless solutions to challenges in energy, environment, materials, biology, computing, and physics.
And this same approach will continue to deliver breakthroughs for decades to come.
In 2021, Berkeley Labs 90th year, we invite you to join our anniversary celebration, Berkeley Lab: The Next 90, as we celebrate our past and imagine our future.
The pursuit of discovery science by multidisciplinary teams has brought, and will continue to bring, tremendous benefits to the nation and world, said Berkeley Lab Director Mike Witherell. Our celebration is a chance to honor everyone who has contributed to solving human problems through science, and to imagine what we can accomplish together in the next 90 years.
Berkeley Labs 90th anniversary celebration honors the diverse efforts of the Lab community: from scientists and engineers to administrative and operations staff.
It also celebrates our commitment to discovery science, which explores the fundamental underpinnings of the universe, materials, biology, and more. This research requires patience the dividends can be decades in the future but the results are often surprising and profound, from the cyclotron of yesteryear to todays CRISPR-Cas9 genetic engineering technology.
Its an incredible story were proud to share, and inspired to continue with your support. Over the next several months, well offer many ways to join our celebration. Visit Berkeley Lab: The Next 90 to learn more, and engage with us on Twitter at #BerkeleyLab90.
Here are several ways to join our celebration, all highlighted on the website:
Celebrate the past
90 Breakthroughs: To celebrate Berkeley Labs nine decades of transforming discovery science into solutions that benefit the world, well roll out 90 Berkeley Lab breakthroughs over the next several months.
Interactive Timeline: Explore the Labs many remarkable achievements and events through the decades.
History and photos: Check out our decade-by-decade photo album and historical material.
Imagine the Future
Charitable giving: In 2021, Berkeley Lab will support five non-profit organizations that help prepare young scholars to become leaders and problem solvers.
Basics 2 Breakthroughs: Research at Berkeley Lab often starts with basic science, which leads to breakthroughs that help the world. In this video series, early career scientists discuss their game-changing research and what inspires them.
A Day in the Half Life: This podcast series chronicles the incredible and often unexpected ways that science evolves over time, as told by scientists who helped shape a research field, and those who will bring it into the future.
Speaker series: These monthly lectures offer a look at game-changing scientific breakthroughs of the last 90 years, highlight current research aimed at tackling the nations most pressing challenges, and offer a glimpse into future research that will spur discoveries yet to be made.
Connect
Virtual tours: These live, interactive tours will enable you to learn more about Berkeley Labs research efforts, hear from the scientists who conduct this important work, and peek inside our amazing facilities.
Social media: Join us on social media for fun and engaging content that will help you discover the Labs incredible history, and learn what were imagining for the future. BerkeleyLab#90
# # #
Founded in 1931 on the belief that the biggest scientific challenges are best addressed by teams,Lawrence Berkeley National Laboratoryand its scientists have been recognized with 13 Nobel Prizes. Today, Berkeley Lab researchers develop sustainable energy and environmental solutions, create useful new materials, advance the frontiers of computing, and probe the mysteries of life, matter, and the universe. Scientists from around the world rely on the Labs facilities for their own discovery science. Berkeley Lab is a multiprogram national laboratory, managed by the University of California for the U.S. Department of Energys Office of Science.
DOEs Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visitenergy.gov/science.
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Berkeley Lab Celebrates 90th Anniversary, Imagines the Next 90 Years | Berkeley Lab - Lawrence Berkeley National Laboratory
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Synthetic Biology Used To Develop a New Type of Genetic Design – Technology Networks
Posted: at 8:08 am
Richard Feynman, one of the most respected physicists of the twentieth century, said "What I cannot create, I do not understand". Not surprisingly, many physicists and mathematicians have observed fundamental biological processes with the aim of precisely identifying the minimum ingredients that could generate them. One such example are the patterns of nature observed by Alan Turing. The brilliant English mathematician demonstrated in 1952 that it was possible to explain how a completely homogeneous tissue could be used to create a complex embryo, and he did so using one of the simplest, most elegant mathematical models ever written. One of the results of such models is that the symmetry shown by a cell or a tissue can "break" under a set of conditions. However, Turing was not able to test his ideas, and it took over 70 years before a breakthrough in biology technique was able to evaluate them decisively. Can Turing's dream be made a reality through Feynman's proposal? Genetic engineering has proved it can.
Now, a research team from the Institute of Evolutionary Biology (IBE), a joint centre of UPF and the Spanish National Research Council (CSIC), has developed a new type of model and its implementation using synthetic biology can reproduce the symmetry breakage observed in embryos with the minimum amount of ingredients possible.
The research team has managed to implement via synthetic biology (by introducing parts of genes of other species into the E. coli bacteria) a mechanism to generate spatial patterns observed in more complex animals, such as Drosophila melanogaster (fruit fly) or humans. In the study, the team observed that the strains of modified E. coli, which normally grow in (symmetrical) circular patterns, do as in the shape of a flower with petals at regular intervals, just as Turing had predicted.
"We wanted to build symmetry breaking that is never seen in colonies of E. coli, but is seen in patterns of animals, and then to discover which are the essential ingredients needed to generate these patterns", says Salva Duran-Nebreda, who conducted this research for his doctorate in the Complex Systems laboratory and is currently a postdoctoral researcher at the IBE Evolution of Technology laboratory.
Bacteria E. coli forming patterns induced by the new synthetic system. Credit: Jordi Pla /ACS.
Using the new synthetic platform, the research team was able to identify the parameters that modulate the emergence of spatial patterns in E. coli . "We have seen that by modulating three ingredients we can induce symmetry breaking. In essence, we have altered cell division, adhesion between cells and long-distance communication capacity (quorum sensing), that is to say, perceive when there is a collective decision", Duran-Nebreda comments.
The observations made in the E. coli model could be applied to more complex animal models or to insect colony design principles. "In the same way that organoids or miniature organs can help us develop therapies without having to resort to animal models, this synthetic system paves the way to understanding as universal a phenomenon as embryonic development in a far simpler in vitro system", says Ricard Sol, ICREA researcher with the Complex Systems group at the IBE, and head of the research.
The model developed in this study, the first of its kind, could be key to understanding some embryonic development events. "We must think of this synthetic system as a platform for learning to design different fundamental biological mechanisms that generate structures, such as the step from a zygote to the formation of a complete organism. Moreover, such knowledge on the frontier between mechanical and biological processes, could be very useful for understanding developmental disorders", Duran-Nebreda concludes.
Reference: Duran-Nebreda S, Pla J, Vidiella B, Piero J, Conde-Pueyo N, Sol R. Synthetic Lateral Inhibition in Periodic Pattern Forming Microbial Colonies. ACS Synth Biol. 2021. doi:10.1021/acssynbio.0c00318.
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.
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Synthetic Biology Used To Develop a New Type of Genetic Design - Technology Networks
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Are Scientists ‘Literally Creating Glow-in-the-Dark Trees’ With Firefly DNA? – Snopes.com
Posted: at 8:08 am
In a Jan. 30, 2021, TikTok video, user niklongo blew the minds of his collective audience with a purported scientific development by Dutch scientists:
You wanna have your mind blown?
Dutch scientists have located and isolated the gene that makes fireflies able to glow, recombined the DNA, and put that DNA in plants, literally creating glow-in-the-dark trees. Eco-friendly outdoor nightlights!
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Broadly speaking, these claims stem primarily from confused and overhyped reporting that, at the time of the TikTok video, was over six years old. While scientists have inserted genes into plants that create a faint glow, glowing trees remain theoretical. The imagery used in the video stems from artwork inspired by but not created with this largely theoretical technology. Below, we break down all the problems with the assertions in the video:
Two words in, and already we are in trouble. The video asserts that Dutch scientists are responsible for locating and isolating the gene that makes fireflies able to glow. This is incorrect. The videos Dutch connection is an artist and designer named Daan Roosegaarde who did not actually locate or isolate any genes, or put said genes in a tree. Some of the images used in the TikTok video were created by Roosegaarde, but these were created by literally shining lights on trees as part of an art installation called Glowing Nature.
In 2014, Roosegaarde received a splash of U.S. media coverage while promoting his work at that years SXSW festival in Austin, TX. During an interview in which he discussed using biologically inspired technology to solve environmental problems, he explained that the idea of using glowing trees as street lamps was inspired in part by the work of former SUNY Stony Brook professor Alexander Krichevsky, who in 2011 left his academic post to start a company named Bioglow. The company developed the worlds first autoluminescent (light producing) plants, according to an archived version of the companys website.
Bioglow apparently no longer exists, but it did produce and sell a limited run of faintly glowing plants. Unlike the imagery shown in the TikTok, the glowing effect in these plants was significantly more modest. Some people over 40 may not be able to see the glow, explained a Bioglow promotional video from August 2015:
In the 2014 SXSW video, Roosegaarde held one of these early Bioglow plants as an example of biomimicry that inspires his art. Several reporters apparently falsely concluded that the Bioglow plant was an invention that Roosegaarde conceived of and helped to develop. This does not appear to be accurate. While some reports suggested there were or are theoretical plans for the artist and the scientist to collaborate on a really large [autoluminescent plant] like a tree which glows at night instead of standard street lighting, there is no indication anything came of this collaboration, if it materialized at all.
Contact information for Krichevsky was not readily apparent. We reached out to Roosegaardes studio for more information on their work together and will update our piece if we receive new information.
Contrary to the claim in the TikTok video, the creation of genetically modified glowing plants does not, at any point, introduce genes sourced from fireflies. Part of the confusion is that several academic or commercial enterprises are attempting, or have attempted, to create glowing plants. All of these efforts involve, in some way, the chemical luciferase, which reacts with a group of chemicals termed luciferins in a way that generates light. This chemical mechanism, generally speaking, is responsible for bioluminescence in several organisms, including fireflies.
Several glowing plant projects attempt to create luminescence by directly injecting or applying luciferins and luciferase into or on them. One of the most notable efforts using this sort of methodology comes from the laboratory of Michael Strano, a professor of chemical engineering at MIT developing a nanoparticle delivery mechanism. These efforts have also received significant (and more recent) media coverage, but this work is not actually genetic engineering.
As far as we are aware, the only person to attempt to use genetic engineering to create glowing plants is Krichevsky. The central difference in his approach compared to those that apply luciferin-related chemicals is that Krichevskys plants are autoluminescent. In other words, he modified the genes of a plant in a way that allows it to create its own luciferins and luciferase.
However, the genetic material inserted into the plants genome does not come from fireflies. Krichevsky published his methodology for engineering his plants in a 2010 paper. The genes it uses are sourced from the bioluminescent marine bacteria Photobacterium leiognathi. In neither method would it be accurate to say genes are isolated from fireflies.
A commonly invoked vision for people involved in glowing plant research is a future where energy consumption is reduced thanks to glowing trees that could serve as self-powered streetlamps.
Speaking to the outlet Dezeen in 2014, Krichevsky explained, In the long term we see use of glowing plants in contemporary lighting design, namely in landscaping and architecture as well as in transportation, marking driveways and highways with natural light that does not require electricity.
In an article introducing his SXSW interview a few months later, Dezeen introduced Roosegaarde as someone exploring ways of using bioluminescent bacteria found in jellyfish and mushrooms to create glow-in-the-dark trees that could replace street lights.
Our target is to perform one treatment when the plant is a seedling or a mature plant, and have it last for the lifetime of the plant, Strano said in the 2017 MIT Press release. Our work very seriously opens up the doorway to streetlamps that are nothing but treated trees, and to indirect lighting around homes.
In none of these cases, however, did these individuals literally create a glowing tree. The technology simply is not there yet. Krichevskys plants were not trees, but instead modified tobacco plants, which are commonly used in genetic research. The imagery used in the TikTok video comes from either art installations made by Roosegaarde which only mimicked the technology, or from computer-generated concept art, not literal glowing trees. Sadly.
Because glowing trees do not (yet) exist, because firefly genes are not used in this area of research, and because the work is falsely attributed to Dutch scientists, the claims presented in niklongos TikTok are False.
Excerpt from:
Are Scientists 'Literally Creating Glow-in-the-Dark Trees' With Firefly DNA? - Snopes.com
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Antibody Isotyping Kit Market: Rise in awareness about diseases and improvement in the health care infrastructure is expected to drive the market -…
Posted: at 8:08 am
Antibody Isotyping Kit: Introduction
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Key Drivers and Restraints of Global Antibody Isotyping Kit Market
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Governments of several countries are investing in diagnostic health care. According to the World Bank, global healthcare expenditure was 6% of GDP. In 2016, world health care expenditure was US$ 6.5 Trn. In 2015, health care spending in the U.S. increased by 5.8% to reach US$ 3.2 Trn. The overall share of the U.S. economy devoted to health care spending was 17.8% in 2015, up from 17.4% in 2014. In 2015, total government health care expenditure in Europe was 7.2% of GDP.
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Key Players Operating in Global Antibody Isotyping Kit Market
Manufacturers in the global antibody isotyping kit market are increasingly investing in research & development of new and innovative techniques for screening and diagnosis. These players are also focused on offering highly efficient and reliable products.
Leading companies operating in the global antibody isotyping kit market include:
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Global Antibody Isotyping Kit Market, by Product
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Antibody Isotyping Kit Market: Rise in awareness about diseases and improvement in the health care infrastructure is expected to drive the market -...
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Novavax Announces Start of Rolling Review by Multiple Regulatory Authorities for COVID-19 Vaccine Authorization | Vaccines | News Channels -…
Posted: at 8:08 am
DetailsCategory: VaccinesPublished on Friday, 05 February 2021 11:17Hits: 363
GAITHERSBURG, MD, USA I February 04, 2021 I Novavax, Inc. (Nasdaq: NVAX), a biotechnology company developing next-generation vaccines for serious infectious diseases, today announced the start of the rolling review process for authorization of NVX-CoV2373, its COVID-19 vaccine, by multiple regulatory agencies. The reviews will continue while the company completes its pivotal Phase 3 trials in the United Kingdom (U.K.) and United States (U.S.) and through initial authorization for emergency use granted under country-specific regulations.
The rolling review of our submission by regulatory authorities of non-clinical data and early clinical studies will help expedite the review process and bring us that much closer to delivering a safe and effective vaccine worldwide, said Gregory M. Glenn, MD, President of Research and Development, Novavax. We appreciate the agencies confidence in Novavax based on our early data and the collective sense of urgency to ensure speedier access to much-needed COVID-19 vaccination.
To date, Novavax has begun the rolling review process with several regulatory agencies worldwide, including the European Medicines Agency (EMA), U.S. Food and Drug Administration (FDA), U.K. Medicines and Healthcare products Regulatory Agency (MHRA), and Health Canada. As part of the rolling review, the company will continue to submit additional information, including clinical and manufacturing data.
Novavax recombinant protein-based vaccine candidate is currently in Phase 3 clinical development in both the U.K. and U.S. for the prevention of COVID-19. It was the first vaccine to demonstrate clinical efficacy against the original strain of COVID-19 and both of the rapidly emerging variants in the United Kingdom and South Africa.
About NVX-CoV2373
NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of SARS-CoV-2, the virus that causes COVID-19 disease. NVX-CoV2373 was created using Novavax recombinant nanoparticle technology to generate antigen derived from the coronavirus spike (S) protein and is adjuvanted with Novavax patented saponin-based Matrix-M to enhance the immune response and stimulate high levels of neutralizing antibodies. NVX-CoV2373 contains purified protein antigen and can neither replicate, nor can it cause COVID-19. In preclinical studies, NVX-CoV2373 induced antibodies that block binding of spike protein to cellular receptors and provided protection from infection and disease. It was generally well-tolerated and elicited robust antibody response numerically superior to that seen in human convalescent sera in Phase 1/2 clinical testing. NVX-CoV2373 is currently being evaluated in two pivotal Phase 3 trials: a trial in the U.K that demonstrated 89.3 percent overall efficacy and 95.6 percent against the original strain in a post-hoc analysis, and the PREVENT-19 trial in the U.S. and Mexico that began in December. It is also being tested in two ongoing Phase 2 studies that began in August: A Phase 2b trial in South Africa that demonstrated up to 60 percent efficacy against newly emerging escape variants, and a Phase 1/2 continuation in the U.S. and Australia.
About Matrix-MNovavax patented saponin-based Matrix-M adjuvant has demonstrated a potent and well-tolerated effect by stimulating the entry of antigen presenting cells into the injection site and enhancing antigen presentation in local lymph nodes, boosting immune response.
About NovavaxNovavax, Inc.(Nasdaq: NVAX) is a biotechnology company that promotes improved health globally through the discovery, development and commercialization of innovative vaccines to prevent serious infectious diseases. The companys proprietary recombinant technology platform combines the power and speed of genetic engineering to efficiently produce highly immunogenic nanoparticles designed to address urgent global health needs. Novavaxis conducting late-stage clinical trials for NVX-CoV2373, its vaccine candidate against SARS-CoV-2, the virus that causes COVID-19. NanoFlu, its quadrivalent influenza nanoparticle vaccine, met all primary objectives in its pivotal Phase 3 clinical trial in older adults and will be advanced for regulatory submission. Both vaccine candidates incorporate Novavax proprietary saponin-based Matrix-M adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies.
For more information, visit http://www.novavax.com and connect with us on Twitter and LinkedIn.
SOURCE: Novavax
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Novavax Announces Start of Rolling Review by Multiple Regulatory Authorities for COVID-19 Vaccine Authorization | Vaccines | News Channels -...
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Uncertain future: Will Europe’s Green Deal encourage or cripple crop gene-editing innovation? – Genetic Literacy Project
Posted: at 8:08 am
The EU Green Deal and its Farm-to-Fork and Biodiversity Strategies stipulate ambitious policy objectives that will fundamentally impact agricultural businesses and value chains. Are these objectives realistic? And how do they fit with the EUs policies on food security, the internal market, international trade and multilateral economic agreements? As significant conflicts of goals become apparent, the discussion on expectations, preconditions and consequences is now underway.
The Farm to Fork Strategy concretely foresees a reduction of pesticide and fertilizer use of 50% and 20% by 2030, respectively. In addition, 25% of EUs agricultural land is supposed to be put under organic farming conditions, which generally means a reduction in productivity. Unfortunately, the strategy is less concrete about the important role of innovation in general and plant breeding innovation specifically to compensate for productivity losses and to contribute to a more sustainable agriculture.
On July 25, 2018 the European Court of Justice (ECJ) published its ruling on mutagenesis breeding, including targeted genome editing techniques. This ruling subjected new tools like CRISPR Cas-9 to the EUs strict rules and requirements for GMOs, and with that effectively prohibited European plant breeders and farmers from utilizing these powerful technologies. These regulatory obstacles are not based on evidence showing that genome editing poses a risk to human health or the environment, but rather on political interference in the regulatory approval process. The COVID pandemic made this abundantly clear. In July 2020, for example, the EU suspended some of its excessive genetic engineering rules to facilitate the development of COVID vaccines, and has since celebrated the approval of these important drugs while trying to prevent the use of biotechnology in agriculture.
Since the discovery of the laws of genetics by Gregory Mendel in 1866, plant breeders have continuously integrated the latest plant biology innovations into their toolbox to develop enhanced crops that help farmers sustainably grow the food we all depend on.
Europes seed sector, technology developers and public researchers have always been important actors in this evolving effort and remain global leaders in developing improved plant breeding methods. They work tirelessly to provide farmers with crop varieties that fit the needs of a highly productive and sustainable agriculture system and meet the exacting demands of consumers. It is no secret that these experts understand the value of new breeding techniques (NBTs) like CRISPR and want to employ them.
Contrary to the claim of some environmental groups that genome editing provides new avenues of control through modifying specific plant traits, most notably insect and herbicide resistance, industrial applications of this sort are only one aspect of NBT research, and a minor one at that. Our recent survey of 62 private plant breeding companies, 90% of which are small and medium size firms (SMEs), confirms that EU plant breeders are able and willing to use these technologies to develop a wide range of crop species and traits for farmers. From grape vine to wheat, NBTs can generate innovation to protect Europes traditional crops from pests and diseases and other threats posed by climate change.
Independent of their size, many companies are already using NBTs in their R&D pipelines for technology development, gene discovery and to produce improved plant varieties. These activities cover a wide range of agricultural and horticultural cropsfrom the so-called cash crops like maize and soybean to minor crops like pulses, forage crops and chicoryand span a wide diversity of characteristics, including yield, plant architecture, disease and pest resistance, food-quality traits and abiotic stresses like drought and heat.
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Bayer’s ThryvOn Technology Moves Forward – Southeast AgNet
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The U.S. Department of Agricultures (USDA) Animal and Plant Health Inspection Service (APHIS) recently announced the deregulation of a cotton variety, designated as MON 88702, otherwise known as ThryvOn Technology. It was developed by the Monsanto Company, which is now owned by Bayer. It uses genetic engineering for resistance to certain insects, primarily tarnished plant bugs.
APHIS considered all public comments and conducted a thorough review of the potential environmental impacts in its final EA pursuant to the National Environmental Policy Act (NEPA), reaching a finding of no significant impact. They concluded the MON 88702 cotton variety is unlikely to pose a plant pest risk to agricultural crops or other plants in the U.S. and deregulated it, effective Jan. 19, 2021.
Bayers ThryvOn Technology represents the industrys first cotton biotech trait to protect against feeding damage from key tarnished plant bug and thrips species. These include tobacco thrips, Western flower thrips, tarnished plant bug and the Western Tarnished Plant bug. The technology provides cotton growers an additional tool to manage these damaging pests.
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Bayer's ThryvOn Technology Moves Forward - Southeast AgNet
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