Category Archives: Genetic Engineering

PUBLIC RELEASE DATE:

21-May-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, May 21, 2014A targeted gene silencing strategy blocks production of the dysfunctional huntingtin (Htt) protein, the cause of Huntington's disease, a fatal, inherited neurodegenerative disorder. The effectiveness of this RNA interference (RNAi) approach in reducing levels of mutant Htt protein and disease symptoms in a mouse model of the disease is described in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Human Gene Therapy website.

Lisa Stanek and coauthors from Genzyme (Framingham, MA) used an adeno-associated viral (AAV) vector to deliver a targeted nucleic acid sequence called a small interfering RNA (siRNA) into the cells of affected mice. The siRNA selectively binds to the mutated gene, blocking disease-causing Htt production. The authors present data demonstrating the ability to deliver the therapeutic RNAi into the cells, reduce mutant Htt levels, and impact behavioral deficits in the mice without causing any noticeable neurotoxicity, in their article "Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease."

"The Genzyme group uses state-of-the-art delivery technology and a gene silencing approach to generate very promising preclinical data for Huntington's disease," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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About the Journal

Human Gene Therapy, the official journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German Society of Gene Therapy, and five other gene therapy societies, is an authoritative peer-reviewed journal published monthly in print and online. Human Gene Therapy presents reports on the transfer and expression of genes in mammals, including humans. Related topics include improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, as well as ethical, legal, and regulatory issues related to the gene transfer in humans. Its sister journals, Human Gene Therapy Methods, published bimonthly, focuses on the application of gene therapy to product testing and development, and Human Gene Therapy Clinical Development, published quarterly, features data relevant to the regulatory review and commercial development of cell and gene therapy products. Tables of content for all three publications and a free sample issue may be viewed on the Human Gene Therapy website.

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Novel RNAi therapy silences mutated Huntington's disease gene and reduces symptoms

PUBLIC RELEASE DATE:

20-May-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, May 20, 2014Studies have identified mobile phones and related devices as sources of metal sensitization and potential causes of allergic contact dermatitis (ACD). Despite efforts to control allergen release in phones, many phones on the market release levels of metals, such as nickel and chromium, which are sufficient to induce ACD, according to an article in Pediatric Allergy, Immunology, and Pulmonology, a peer-reviewed journal published by Mary Ann Liebert, Inc., publishers. The article is available free on the Pediatric Allergy, Immunology, and Pulmonology website at http://online.liebertpub.com/doi/full/10.1089/ped.2013.0308.

In the article "Mobile Phone Dermatitis in Children and Adults: A Review of the Literature," a team of researchers led by Jacob Thyssen, MD, PhD, Copenhagen University Hospital Gentofte (Hellerup, Denmark), Loma Linda University School of Medicine (Loma Linda, CA), and University of Arizona College of Medicine (Phoenix, AZ), review the current literature on mobile phone dermatitis in both children and adults. Nickel sensitization is common in children, resulting in ACD prevalence levels of up to 33%. This information is important for practitioners, particularly when evaluating patients with dermatitis of the face, neck, hands, breast, or anterior thighscommon places exposed to cell phones. The authors provide important diagnostic tips for practitioners and strategies to raise awareness of nickel- or chromium-induced mobile phone ACD.

"With the rising use of cell phones and other mobile devices, pediatricians can expect to see additional cases of ACD," says Editor-in-Chief Mary Cataletto, MD, Professor of Clinical Pediatrics, State University of New York at Stony Brook (Stony Brook, NY) and practicing pediatric pulmonologist at Winthrop University Hospital. "Thyssen's paper discusses diagnostic patch testing for common metal allergens and the value of spot testing of the patient's phone in establishing a causal relationship."

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About the Journal

Pediatric Allergy, Immunology, and Pulmonology is a quarterly peer-reviewed journal published in online with Open Access options and in print. The Journal synthesizes the pulmonary, allergy, and immunology communities in the advancement of the respiratory health of children. The Journal provides comprehensive coverage to further the understanding, and optimize the treatment, of some of the most common and costly chronic illnesses in children. It includes original translational, clinical, and epidemiologic research; public health, quality improvement, and case control studies; patient education research; and the latest research and standards of care for functional and genetic immune deficiencies and interstitial lung diseases. Tables of content and a sample issue may be viewed on the Pediatric Allergy, Immunology, and Pulmonology website at http://www.liebertpub.com/ped.

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Can mobile phones cause allergic reactions?

Early genetic engineering experiment

By: Rafa_el

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Early genetic engineering experiment - Video

Req ID: 7661

Overview: Marathon Oil Corporation is an international energy company engaged in exploration and production; oil sands mining;and integrated gas.

Marathon Oil has a major leasehold position in the core of the Eagle Ford Shale formation in South Texas.

The Company holds acreage in the Eagle Ford, focusing on Atascosa, DeWitt, Gonzales, and Karnes counties.

Marathon Oil's Eagle Ford Subsurface team is seeking an Engineering Technician to support our Kenedy group.

The successful candidate will support the Eagle Ford subsurface team primarily with company operated assets.

The candidate will be expected to work closely with multidisciplinary teams and management in support of a variety of development activities and functions.

This position will report to a Subsurface Manager for the Eagle Ford Asset Team and will be located in Houston.

Responsibilities:

Preferred Qualifications:

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Engineering Technician Job

PUBLIC RELEASE DATE:

19-May-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, May 19, 2014Two studies of the anti-depressive drug duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), compared its effectiveness and safety to either fluoxetine or placebo in children and adolescents with major depressive disorder (MDD). The results of these first controlled trials of duloxetine in pediatric patients with MDD are published in Journal of Child and Adolescent Psychopharmacology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available free on the Journal of Child and Adolescent Psychopharmacology

Graham Emslie, MD and coauthors evaluated the efficacy and safety of a fixed dose of duloxetineeither 60 mg or 30 mg once a dayversus 20 mg daily of fluoxetine or placebo in children ages 7-11 years and adolescents ages 12-17 years. In the article "A Double-Blind Efficacy and Safety Study of Duloxetine Fixed Doses in Children and Adolescents with Major Depressive Disorder" they compare the treatments based on worsening of suicidal ideation, emergence of suicidal behavior, and adverse effects including abnormal findings on an electrocardiogram and laboratory tests.

Sarah Atkinson, MD and colleagues compared a flexible dosing regimen of duloxetine (60-120 mg daily) to fluoxetine (20-40 mg daily) or placebo and reported measures from a depression rating scale and a suicide severity rating scale, as well as treatment-related adverse events, in the article "A Double-Blind Efficacy and Safety Study of Duloxetine Flexible Dosing in Children and Adolescents with Major Depressive Disorder".

Neither study found a significant difference in response between the two drugs and placebo. The authors suggest that this may be due to the complexity of these novel studies and offer observations that may direct the design of future investigations.

"Drs. Emslie and Atkinson and their colleagues took a fascinating approach towards testing the efficacy of a novel SNRI in the pediatric population," said Harold S. Koplewicz, MD, Editor-in-Chief of Journal of Child and Adolescent Psychopharmacology, and President, Child Mind Institute, New York, NY. "Researchers are of course excited by positive results, but in this case the curious lack of response tells us volumes about how to better design complex studiesstudies that may soon give us uncommon insight into our pharmacologic interventions."

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Is Duloxetine more or less effective than Fluoxetine in children and teens with MDD?

On The Offensive Against GMOs with Jeffrey Smith
Genetic engineering of foods is one of the most controversial subjects of the last two decades. Since humans first domesticated crops and animals, people have bred different breeds and species...

By: NextNewsNetwork

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On The Offensive Against GMOs with Jeffrey Smith - Video

Understanding The Science For Tomorrow 10 Genetic EngineeringLife #39;s Building Blocks {audiobook}
Entire playlist: https://www.youtube.com/playlist?list=PLT6gX_wy0SNrGEsl9Q9tBDWP0gWcG7eIO.

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Understanding The Science For Tomorrow 10 Genetic EngineeringLife's Building Blocks {audiobook} - Video

Genetic Engineering Research Project
Genetic Engineering Project (Cloning, DNA extractionn; Artificial selection/ Selective breeding) and squid cause hes a squid.

By: Keshaun Ram

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Genetic Engineering Research Project - Video

B3 Selective Breeding and Genetic Engineering
Revision video for OCR unit B3.

By: Lucy Owen

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B3 Selective Breeding and Genetic Engineering - Video

1. Introduction - Gender Equations In FreeThought (Malayalam) By Rukshana Mahamood
A feminist student #39;s take on the gender roles and representation of genders across realms of thought. Rukshana Mahamood is an undergraduate student of Genetic Engineering in Chennai. Aspiring...

By: Kerala Freethinkers Forum Official

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1. Introduction - Gender Equations In FreeThought (Malayalam) By Rukshana Mahamood - Video