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Category Archives: Genetic Engineering
Germany Is Threatening Biohackers With Prison – Gizmodo
Posted: February 10, 2017 at 2:47 am
Over the last few years, advances in science have made the kind of experiments once only accessible to PhDs with fancy labs far more attainable. College undergrads are constructing gene drives. Anyone can buy a kit on the internet to concoct their own bioluminescent beer.
The German government, it seems, is none too pleased with this development. Two weeks ago its consumer protection office issued a statement making clear just how upset it is: Any science enthusiast doing genetic engineering outside of a licensed facility, it wrote, might face a fine of 50,000 or up to three years in prison.
The statement sent a wave of shock through the DIY bio community.
This is the first time Ive ever heard of a government calling out the DIY community specifically, said Todd Kuiken, a senior research scholar with the Genetic Engineering and Society Center at North Carolina State University.
The law behind the German DIY bio crackdown isnt new. The government was simply reminding so-called biohackers of a long-existing law that forbids genetic engineering experiments outside of laboratories supervised and licensed by the state.
But there is concern over how the pledge to enforce those rules may stymy the growth of the DIY science movement, and whether Germanys statement may inspire other European nations to take a similarly firm stance.
I am worried that the mentality could spread to other countries, said Josiah Zayner, who runs The Odin, a US company that sells DIY CRISPR kits.
Europe is generally much stricter in its regulation of genetic engineering and genetically modified products than the United States. In some countries, it is unclear whether DIY genetic engineering is legal at all.
A spokesperson for Germanys consumer protection office, the BVL, told Gizmodo that officials gathered in November to discuss concerns over the appearance of cheap DIY genetic engineering kits for sale on the internet, and decided it should issue a warning. Companies like The Odin and Amino Labs sell kits that make experimenting with DNA not much more difficult that whipping up a batch of brownies with a box of mix. Amino Labs compact, table-top bacteria lab is even sort of reminiscent of an Easybake oven, with its bright colors and playful name, the DNA Playground.
The statement has to be seen in light of the newly formed DIY biology scene and due to the appearance of low-priced DIY biology kits in online shops, the BVL told Gizmodo, via email.
At the moment, the BVL said it has not used the law to bring any criminal chargers against biohackers, though it may do so in the future.
Its difficult, but not impossible, for an individual in Germany to receive explicit government permission to do genetic engineering experiments outside of a lab. In Ireland, a PhD dropout named Cathal Garvey won such approval from the Irish government back in 2012.
Im pretty sure that laws will prohibit me from continuing my research at a later state, said Bruno Lederer, a German biohacker who hopes that loopholes in the law will allow his work to continue for now. I think its a shame that Id have to do illegal things in order to do independent research.
The BVL conceded that the new rules will make it virtually impossible for a lone scientist to meet the legal requirements to do genetic engineering. To begin with, any lab needs a project manager qualified by academic credentials such as a masters degree in science. Labs also require a commissioner for biological safety who is similarly qualified.
This makes genetic engineering experiments rather unattractive for individuals, the BVLs spokesman said.
Community biology labs, which often receive oversight and advisement from traditional scientists, shouldnt have an issue getting licensed. But not every DIY scientist lives near or has the resources to join a community lab. If the DIY bio movement is about making science accessible to those outside the Ivory Tower of academia, the German governments statement represents a serious roadblock.
If you are not living in a big city, access to a community biolab or an informal learning environment like a maker space is difficult, said Orkan Telhan, whose company, Biorealize, is in the process of developing its own DIY bio kits. There is no doubt that the field has to be regulated to mitigate adverse outcomes, but we need alternative ways to engage new audiences with biology.
In the US, biohackers operate in more of a regulatory gray areaoften regulations do not apply to them simply because no one ever conceived that self-taught scientists would one day pursue sophisticated biology experiments in their garages. But as the DIY community here has grown and sought to not just experiment at home, but sell its creations to the public, it, too, has increasingly faced regulatory run ins. In the US, DIY scientists are subject to the same rules as any other scientists. As in Germany, those regulations can be difficult to comply for an individual to comply with.
I dont think its entirely uncalled for to evaluate some of these spaces like community labs to make sure that they are operating in a safe manner, said Kuiken. I think that they are already operating safely, but currently there is no system in the US to determine that.
Germanys statement does offer one silver lining: it offers the rare clear guidance for what rules biohackers must comply with in order to go about their work legally.
Germany stating their position is a step forward in clarification, said Julie Legault of Amino Labs. Hopefully other countries will clarify their own rules as well.
The only question now is whether those rules will prevent biohackers from continuing with their work at all.
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New method of genetic engineering indispensable tool in … – Phys.org – Phys.Org
Posted: at 2:47 am
February 9, 2017 by Kathryne Metcalf Restriction enzymes are essential tools for recombinant DNA technology that have revolutionized modern biological research, however have limited sequence specificity and availability. The Pyrococcus furiosus Argonaute (PfAgo) based platform for generating artificial restriction enzymes (AREs) is capable of recognizing and cleaving DNA sequences at virtually any arbitrary site and generating defined sticky ends of varying length. Credit: Behnam Enghiad and Huimin Zhao, University of Illinois at UrbanaChampaign
Research by Professor of Chemical and Biomolecular Engineering Huimin Zhao and graduate student Behnam Enghiad at the University of Illinois is pioneering a new method of genetic engineering for basic and applied biological research and medicine. Their work, reported in ACS Synthetic Biology on February 6, has the potential to open new doors in genomic research by improving the precision and adherence of sliced DNA.
"Using our technology, we can create highly active artificial restriction enzymes with virtually any sequence specificity and defined sticky ends of varying length," said Zhao, who leads a synthetic biology research group at the Carl R. Woese Institute for Genomic Biology at Illinois. "This is a rare example in biotechnology where a desired biological function or reagent can be readily and precisely designed in a rational manner."
Restriction enzymes are an important tool in genomic research: by cutting DNA at a specific site, they create a space wherein foreign DNA can be introduced for gene-editing purposes. This process is not only achieved by naturally-occurring restriction enzymes; other artificial restriction enzymes, or AREs, have risen to prominence in recent years. CRISPR-Cas9, a bacterial immune system used for "cut-and-paste" gene editing, and TALENs, modified restriction enzymes, are two popular examples of such techniques.
Though useful in genetic engineering, no AREs generate defined "sticky ends"an uneven break in the DNA ladder-structure that leaves complementary overhangs, improving adhesion when introducing new DNA. "If you can cleave two different DNA samples with the same restriction enzyme, the sticky ends that are generated are complementary," explained Enghiad. "They will hybridize with each other, and if you use a ligase, you can stick them together."
However, restriction enzymes themselves have a critical drawback: the recognition sequence which prompts them to cut is very shortusually only four to eight base pairs. Because the enzymes will cut anywhere that sequence appears, researchers rely on finding a restriction enzyme whose cut site appears only once in the genome of their organism or plasmidan often difficult proposition when the DNA at hand might be thousands of base pairs long.
This problem has been partially solved simply by the sheer number of restriction enzymes discovered: more than 3600 have been characterized, and over 250 are commercially available. "Just in our freezer, for our other research, we have probably over 100 different restriction enzymes," said Enghiad. "We look through them all whenever we want to assemble something ... the chance of finding the unique restriction site is so low.
"Our new technology unifies all of those restriction enzymes into a single system consisting of one protein and two DNA guides. Not only have you replaced them, but you can now target sites that no available restriction enzymes can."
Enghiad and Zhao's new technique creates AREs through the use of an Argonaute protein (PfAgo) taken from Pyrococcus furiosus, an archeal species. Led by a DNA guide, PfAgo is able to recognize much longer sequences when finding its cut site, increasing specificity and removing much of the obstacles posed by restriction enzymes. Further, PfAgo can create longer sticky ends than even restriction enzymes, a substantial benefit as compared to other AREs.
"When we started, I was inspired by a paper about a related proteinTtAgo. It could use a DNA guide to cleave DNA, but only up to 70 degrees," explained Enghiad. "DNA strands start to separate over 75 degrees, which could allow a protein to create sticky ends. If there were a protein that was active at higher temperatures, I reasoned, that protein could be used as an artificial restriction enzyme.
"So I started looking for that, and what I found was PfAgo."
In addition to replacing restriction enzymes in genetic engineering processes, Enghiad and Zhao believe their technology will have broad applications in the biological research. By creating arbitrary sticky ends, PfAgo could make assembly of large DNA molecules easier, and enables cloning of large DNA molecules such as biochemical pathways and large genes.
The application of these techniques is broad-reaching: ranging from discovery of new small molecule drugs to engineering of microbial cell factories for synthesis of fuels and chemicals to molecular diagnostics of genetic diseases and pathogens, which are the areas Zhao and Enghiad are currently exploring.
"Due to its unprecedented simplicity and programmability (a single protein plus DNA guides for targeting), as well as accessibility ... we expect PfAgo-based AREs will become a powerful and indispensable tool in all restriction enzyme or nuclease-enabled biotechnological applications and fundamental biological research," said Zhao. "It is to molecular biology as the CRISPR technology is to cell biology."
Explore further: Prevention of RNA virus replication
More information: Behnam Enghiad et al, Programmable DNA-Guided Artificial Restriction Enzymes, ACS Synthetic Biology (2017). DOI: 10.1021/acssynbio.6b00324
Researchers at Okayama University have successfully cleaved influenza viral RNA to prevent its replication using novel artificial RNA restriction enzymes in laboratory cell cultures. While further improvements are needed, ...
Better tools for manipulating DNA in the laboratory may soon be possible with newly discovered deoxyribozymes (catalytic DNA) capable of cleaving single-stranded DNA, researchers at the University of Illinois say.
Scientists have shed new light on the way superbugs such as MRSA are able to become resistant to treatment with antibiotics.
Genetic engineering of plants, animals and microorganisms such as bacteria typically involves the use of restriction enzymes to 'cut and paste' DNA fragments into certain genetic sequence locations. This process allows scientists ...
Researchers at the University of Minnesota have discovered a molecular security system in human cells that deactivates and degrades foreign DNA. This discovery could open the door to major improvements in genetic engineering ...
By consuming fewer calories, ageing can be slowed down and the development of age-related diseases such as cancer and type 2 diabetes can be delayed. The earlier calorie intake is reduced, the greater the effect. Researchers ...
Research by Professor of Chemical and Biomolecular Engineering Huimin Zhao and graduate student Behnam Enghiad at the University of Illinois is pioneering a new method of genetic engineering for basic and applied biological ...
The bacterial world is rife with unusual talents, among them a knack for producing electricity. In the wild, "electrogenic" bacteria generate current as part of their metabolism, and now researchers at the University of California, ...
Chemists have developed a powerful new method of selectively linking chemicals to proteins, a major advance in the manipulation of biomolecules that could transform the way drugs are developed, proteins are probed, and molecules ...
Understanding how oil and gas molecules, water and rocks interact at the nanoscale will help make extraction of hydrocarbons through hydraulic fracturing more efficient, according to Rice University researchers.
Researchers from the University of Maryland College Park (UMD) and Baltimore (UMB) campuses have developed a blood test that could help doctors more quickly diagnose schizophrenia and other disorders. Their study, "Redox ...
Scientists at The Australian National University (ANU) have controlled wave-generated currents to make previously unimaginable liquid materials for new technological innovations, including techniques to manipulate micro-organisms.
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Chan Zuckerberg Biohub Awards $50M+ to 47 Investigators – Genetic Engineering & Biotechnology News
Posted: February 9, 2017 at 5:49 am
The Chan Zuckerberg Biohub (CZ Biohub) said today it will commit more than $50 million to fund human disease research by its first cohort of 47 investigators from the faculty of the University of California, Berkeley, Stanford University, and the University of California, San Francisco (UCSF).
Each investigator will receive a five-year appointment and up to $1.5 million toward life science research in their areas of expertise. CZ Biohub said the investigators were selected from several academic departments at the three universities, including biology, chemistry, computer science, engineering, mathematics, and physics.
An international panel of 60 scientists and engineers evaluated more than 700 applications, the Biohub said.
CZ Biohub investigators share our vision of a planet without disease. To realize this vision, we are giving some of the worlds most creative and brilliant researchers access to groundbreaking technology and the freedom to pursue high-risk research, Joseph DeRisi, Ph.D., of UCSF, co-president of the Biohub, said in a statement.
CZ Biohub investigators will challenge traditional thinking in pursuit of radical discoveries that will make even the most stubborn and deadly diseases treatable, added Dr. DeRisi, who co-leads the Biohub with Stephen Quake, D.Phil., of Stanford University.
The investigators have agreed to make their draft publications widely available through pre-print servers to ensure the rapid dissemination of research results, the Biohub said.
Open science will also be advanced, the Biohub added, through plans to establish share technology platforms where Bay Area scientists can further their research and advance efforts to fight disease.
In addition to its investigator program, the Biohub is pursuing large-scale collaborative projects that include an Infectious Disease Initiative and the Cell Atlas.
The Biohub says that its scientists and engineers will apply advanced technologies to fight against infectious diseases with research focused on four key areas: new detection technologies, new treatments, new ways to prevent infection, and new approaches to rapid response when new threats emerge.
Through the Cell Atlas project, the Biohub aims to build an international collaboration that will map the cell types of the human body. The map, which will be available to researchers worldwide, is intended to help researchers gain new insights into cell biology related to the causes of human disease, potentially leading to new therapies.
The Biohub was launched when Mark Zuckerberg and his wife, Priscilla Chan, M.D., set aside $600 million over 10 years toward a research center that will foster collaborations by professionals across multiple disciplines, including engineers, computer scientists, biologists, chemists, and other innovators.
The Biohub was one of two projects announced in September by the Chan Zuckerberg Initiative, named for the pediatrician and the Facebook founder, chairman, and CEO. The Initiative also committed $3 billion toward basic research over the next decade, with the audacious goal of curing, preventing, or managing all diseases by the end of the century.
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Will Biotechnology Regulations Squelch Food and Farming Innovation? – Genetic Literacy Project
Posted: February 7, 2017 at 9:53 pm
Jon Entine, Executive Director, Genetic Literacy Project,oversaw the assignments and the editing of this series
INTRODUCTION:
Genetically engineered crops and animals (GMOs) have been a controversial public issue since the first products were introduced in the 1990s. They have posed unique challenges for governments to regulate. Although most working scientists in the field hold the opinion that genetic engineering, for the most part, is part of a continuum of the human manipulation of our food supply thats gone on for thousands of years, critics contend differently.
Many crop biotechnology skeptics frame their concerns in quasi-religious terms, as a violation of nature or fears that the increased use of GE foods will lead to a corporate takeover of our seed and food systems, and the adoption of an ecologically destructive industrialized agriculture system. GMOs have become a symbol of the battle over what our global, regional and local food systems should look like going forward.
The clout of the food movement that vocally rejects many aspects of conventional farming has exponentially increased since then, promoted by mainstream journalists, scientists and non-profit groups from Michael Pollan to Consumers Union to the Environmental Working Group. Organic leaders and lobbyists, such as Gary Hirshberg, founder of Stonyfield Organics and Just Label It, openly demonize conventional food and farming in defiance of their commitments agreed to in the 1990s that organic food would not be promoted at the expense of conventional agriculture. Attempts to reign in the unchecked influence of the conventional food critics have repeatedly failed; over much of the past decade, theyve had a sympathetic ear in Washington. Partly in response to the prevailing winds, the USDA has evolved increasingly byzantine regulatory structures when it comes to new GE products.
The Genetic Literacy Project 10-part series Beyond the Science II (Beyond the Science I can be viewed here) commences with this introductory article. Leading scientists, journalists and social scientists explore the ramifications of genetic engineering and so-called new breeding technologies (NBTs), specifically gene-editing technologies such as CRISPR. We will post two articles each week, on Tuesday and Wednesday, over the next 5 weeks.
Regulation is at the heart of this ongoing debate. Many scientists and entrepreneurs have come to view the two key agencies regulating GE in the United States the Food and Drug Administration and Department of Agriculture as places where innovation goes to die. Thats an exaggeration, but not without some truth; regulations are inherently political, and the winds have been blowing against technological breakthroughs in agriculture for much of the last decade. On average, it takes upwards of $125 million and 7-10 years for the Agriculture Department to approve a trait, exhausting almost half of a new products 20-year patent protection. No wonder the agricultural sector is consolidating, and most new products are innovated by larger corporations.
The regulatory climate may be changing, perhaps radically, in the United States and possibly in the United Kingdom, as the result of recent elections.
Many of the old rules and regulations regulating GE crops were set up in the 1980s and early 1990s. They are arguably creaky, overly-restrictive and do not account for dramatic increases in our understanding of how genetic engineering works and the now clear consensus on their safety.
Now with NBTs, which are largely unregulated since the techniques were not foreseen 30 years ago when regulations were first formulated, agricultural genetic research is at an inflection point: Will governments make the same mistake that they did previously and regulate innovation almost out of existence, or will they incorporate reasonable risk-risk and risk-benefit calculations in evaluating which technological advances should proceed with limited regulations?
Decisions on these issues will shape not only food and farming in Europe, North America and the industrialized nations, but the food insecure developing world, which looks to the West for regulatory guidance.
Gene Editing and Animals
The second article in our series, by University of California animal geneticist Alison Van Eenennaam, addresses the challenges of regulating genetically engineered animals. She focuses on dehorned cows, which have been developed without gene editing over many years with, at times, less than optimal results. Should gene editing be evaluated on a case-by-case basis triggered by the novelty of the traits, or should the entire process be heavily regulated the general approach favored by the European Union in regulating more conventional genetic engineering?
Pesticide Debate: How Should Agricultural Chemicals Be Regulated to Encourage Sustainability?
Dave Walton, an Iowa farmer, discusses the brouhaha that has erupted in recent years over the use of glyphosate, the active ingredient in the weed killer originally developed under patent by Monsanto. Many GMO critics are now expressing concerns over pesticide use in conventional agriculture, using glyphosate as a proxy for attacking the technology. Are their concerns appropriate? Walton, who grows both GE and non-GE crops and is director of the Iowa Soybean Association, has used glyphosate on his farm since the introduction of herbicide resistant crops in 1996. He uses on average a soda-sized cup of glyphosate per acre, and the use of the herbicide has allowed him to switch from more toxic chemicals. Most strikingly he discusses the sustainability impact if a glyphosate ban is imposed, as many activists are calling for.
Plant pathologist Steve Savage challenges us to think in a more nuanced way about a popular belief that organic farming is ecologically superior to conventional agriculture. The Agricultural Department has been a fractious mess in recent years in its efforts to oversee and encourage new breeding technologies. When the Clinton administration oversaw the founding of the National Organics Standards Board in 1995, USDA officials extracted the commitment from organic industry that the alternative farming system would not be promoted at the expense of conventional agriculture. After all, study after study, then and now, has established that organic farming offers no safety nor clear ecological benefits.
Let me be clear about one thing, said former Secretary of Agriculture Dan Glickman in December 2000. The organic label is not a statement about food safety, nor is organic a value judgment about nutrition or quality.
But thats not whats happened.
Regulations and the NGO Problem in Africa and Asia
While GE crops were pioneered in the United States and embraced in other western coun- tries outside of Europe, there has been resistance in regions of the world where these innovations could arguably bring the most impact: Africa and poorer sections of Asia. Ma- haletchumy Arujanan, executive director of Malaysian Biotechnology Information Centre and editor-in-chief of The Petri Dish, the first science newspaper in Malaysia, takes on the emerging Asian food security crisis posed by a parallel rise in population and living (and food consumption) standards. She reviews the successes and failures in various countries, and the effective campaigns by anti-GMO NGOs, mostly European funded, to block further biotech innovation.
Margaret Karembu, director of International Service for the Acquisition of Agribiotech Applications, Africa regional office (ISSSA) AfriCenter based in Nairobi, has found a similar pattern of mostly European-funded NGOs attempting to sabotage research and spread misinformation about the basic science of crop biotechnology. Africa is the ultimate organic experiment, and farmers have failed miserably using family agro-ecology techniques for decades. Cracks are beginning to form in the anti-GMO wall erected across the continent and there are hopes that young people will be attracted to farming, lured by the introduction of GE crops and other innovations.
Public Opinion and GMOs
Brandon McFadden, assistant professor in the Food and Resource Economics Department, University of Florida, addresses the complex views of consumers regarding innovation and GE foods. The public has a widely distorted perception of what genetic engineering entails, which helps explain why consumers remain so skeptical about technological innovation in farming.
Julie Kelly, a contributing writer to numerous publications including the Wall Street Journal, National Review and the GLP, takes on Hollywood in her analysis of the celebrity embrace of the anti-GMO movement. Who are the movers and shakers manipulating public opinion in favor of the organic movement and against conventional agriculture? Is the celebrity-backed science misinformation campaign working?
Future of GM Research and How the Public Debate May Evolve
Paul Vincelli, extension professor and Provosts Distinguished Service Professor at the University of Kentucky, has been perturbed about the attack on independent university researchers for working with the biotechnology industry over the years. By law, land grant university scientists are required to work with all stakeholders, particularly corporations who are developing the products used by farmers, including organic farmers. No, scientists who partner with corporations in research and product development are not shills. He rejects the knee jerk belief, advanced by many activist critics of GE crops, that corporate funding necessarily corruptsscience and should be banned.
Finally, risk expert David Ropeik has an optimistic take on the future. He believes 2016 may have been a turning point in the debate over GE foods. Technology rejectionists, from Greenpeace to labeling activists, are sounding increasingly shrill and less scientific. Gene editing, he believes, could undercut claims that GE foods are unsafe because they are unnatural. He is convinced, perhaps optimistically, that GE opponents will soon be viewed as science denialists.
We will see.
Anti-GMO critics cite opinion polls and the votes of anti-GMO legislators in Europe and elsewhere as proof that genetic engineering should be curtailed and more heavily regulated. Thats a rickety platform if one believes in science, however; science is not a popularity contest.
The Genetic Literacy Project is a 501(c)(3) non profit dedicated to helping the public, journalists, policy makers and scientists better communicate the advances and ethical and technological challenges ushered in by the biotechnology and genetics revolution, addressing both human genetics and food and farming. We are one of two websites overseen by the Science Literacy Project; our sister site, the Epigenetics Literacy Project, addresses the challenges surrounding emerging data-rich technologies.Jon Entineis the founder of the Science Literacy Project.
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Cheaper blue jeans that are better for the environment? Genetic engineering can make it happen – Genetic Literacy Project
Posted: February 6, 2017 at 2:49 pm
Editors note: This piece is written byDr. Miller, a physician and molecular biologist, who was the founding director of the FDAs Office of Biotechnology.
Genetic engineers have developed a way to produce the two principal components [of blue jeans], cotton fabric and indigo dye, for less money and soon will make commercial blue jean production cheaper than ever.
Bt cotton helps farmers to control major peststhe cotton and pink bollworm and the tobacco budwormwhich account for a quarter of all crop destruction due to insects. From 1996 through 2014, this technology increased cotton yields by an average of 17.3%
Bt cotton is also environmentally friendly. With conventional cotton, farmers control insects by applying huge amounts of chemical pesticides known to harm birds, fish and other aquatic organisms. Lessening the need for pesticides also reduces farm workers exposure to those chemicals.
The other main ingredient in bluejeans, indigo dye, is usually produced synthetically through a complex, multistep process performed with highly toxic chemicals. It requires special facilities and precautions to protect workers and the environment. But indigo dye can also be made using genetically engineered bacteria. This process has fewer steps, uses water instead of toxic organic solvents, incorporates corn syrup as the primary starting material, and yields nontoxic waste products. While it is not yet efficient enough for commercial use, stay tuned.
Instead of accepting critics unsubstantiated claims, consumers should be demanding [genetic engineerings] wider application in agriculture and other industries.
The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:Youd Look Good in Designer Genes
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Genetic Engineering: CRISPR Technology Makes Cows Resist … – Medical Daily
Posted: at 2:49 pm
Scientists have used a gene-editing technology to make cows more resistant to tuberculosis.
The researchers used a tool called CRISPR-Cas9, by which scientists can make changes to DNA in order to potentially make creatures more resistant to diseases, correct detrimental genetic mutations and other applications. In this case, they inserted a gene into cows that would make them resistant to bovine tuberculosis, then successfully bred that resistance into their offspring. Their findings were reported in the journal Genome Biology, with the authors saying the result demonstrates a possible use of the technology and contributes to the concept of gene-editing for agricultural purposes.
Read: The Danger of a Genetically Engineered Virus
Importantly, our method produced no off-target effects on the cow genetics, lead author Dr. Yong Zhang explained, according to the Daily Mail.
A gene-editing technology has created cows that are resistant to tuberculosis. Pixabay. public domain
The researchers from Northwest A&F University in Xianyang, China, wrote in their study that those off-target effects unintended and unrelated results are an issue when it comes to animals whose genes have been purposely modified.
Although it holds great potential to cure or treat disease and other ailments, CRISPR remains a controversial technology, with some people fearing it will be used to create designer babies or be used for unethical purposes.
Source: Zhang Y, Gao Y, Wu H, et al. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biology. 2017.
See also:
How Milk Is Made and Why Humans Drink It
6 Signs of Lactose Intolerance
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Genetic Engineering: CRISPR Technology Makes Cows Resist ... - Medical Daily
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Saving the flavors of centuries: against Flavr Savr and the genetic engineering of taste – Slow food
Posted: at 2:49 pm
Several years ago, in its Retro Report section, the New York Times posted an old video about the genetically modified Flavr Savr tomato, which was developed by Calgene and launched on to the market in 1994 only to be withdrawn a few years later. The video includes clips of a television program from the time. An intrigued woman is shown two tomatoes picked 30 days earlier, neither of which has been refrigerated. The first tomato is perfect: round, bright red and with no signs of softening. The second has wrinkly skin and a dulled color, clearly rotten. The perfect tomato is a Flavr Savr, engineered to maintain the texture, juiciness and color of a freshly picked tomato for longer. However, despite its apparent perfection and characteristics which, from a commercial point of view, should have certainly made it a success, the Flavr Savr vanished not long after it appeared. Why? Because it was missing the one feature more important than any other: flavor.
Fast forward to today, and the latest cover of Science magazine features Tastier Tomatoes, which hints at the research being conducted by a large group of scientists to design a truly perfect tomato with the texture, juiciness and color of a freshly picked tomato, and indeed, the flavor of heirloom tomato varieties.
The premise of the study is that modern commercial tomato varieties are substantially less flavorful than heirloom varieties. Over time, agricultural research has focused on improving the characteristics that determine whether different varieties are commercially successful: yield, disease resistance and firmness. All at the expense of flavor. Often, the tomatoes we buy taste of nothing. They seem like fake fruit, all too perfect to look at, but flavorless. To fix this fault, the team of scientists have studied the characteristics that most affect the flavor of the product, sequencing the whole genome of 398 modern, heirloom and wild varieties. They then selected 160 tomato samples from 100 varieties and grew them in the laboratory, harvested them and submitted them to extensive taste testing by 100 people. The participants voted for the tomatoes based on flavor and, by comparing this information with their genetic analyses, the scientists determined which genes were associated with flavors that the public enjoyed.
Is a new future taking shape for a fruit that the FAO considers to be one of the most high-value in the world? Maybe. A laboratory-made future, completely removed from the land and restricted by private patents, like all genetically modified products. Slow Food on the other hand, supports a different kind of research, namely what farmers have been doing for around 10,000 years: selecting seeds, conserving them, propagating them and developing varieties suited to different soils and climates, based on traditional knowledge. Work that, over centuries, improves the yield, flavor and nutritional value of crops, without compromising biodiversity and, on the contrary, gradually enriching it.
Examples of these crops are cataloged in the Ark of Taste and among Slow Food Presidia: the Platense tomato from Argentina which, despite its far superior flavor compared with commercial tomatoes, has to deal with intense competition from high-yield hybrid varieties that can be produced all year round; the Smooth Skin Geraldton tomato from Australia, which is suffering due to the appearance of greenhouses in Melbourne and Adelaide which enable tomato production all year round; Kurtovo Konare pink tomatoes, whose survival is under threat from foreign varieties with higher yields that are more suited to being transported; and the Torre Canne Regina tomato, grown without irrigation using organic methods in Apulia, which faces almost unbeatable commercial competition from greenhouse-grown cherry tomatoes. We could mention dozens of other such examples of tomatoes that farmers have developed over centuries through careful selection, rather than artificially engineered in the laboratory. And we would prefer a future where the value of naturally flavorful tomatoes is appreciated once more.
Images: Science Magazine, Western Gardens
First offical Slow Food conference in Iran
Slow Food rememebers Predrag Matvejevic
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Saving the flavors of centuries: against Flavr Savr and the genetic engineering of taste - Slow food
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Genetic Engineering – News – Science – The New York Times
Posted: January 29, 2017 at 10:43 pm
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Genetic Engineering - News - Science - The New York Times
Posted in Genetic Engineering
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Genetically modified food – Wikipedia
Posted: December 21, 2016 at 6:43 pm
Genetically modified foods or GM foods, also known as genetically engineered foods, are foods produced from organisms that have had changes introduced into their DNA using the methods of genetic engineering. Genetic engineering techniques allow for the introduction of new traits as well as greater control over traits than previous methods such as selective breeding and mutation breeding.[1]
Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its unsuccessful Flavr Savr delayed-ripening tomato.[2][3] Most food modifications have primarily focused on cash crops in high demand by farmers such as soybean, corn, canola, and cotton. Genetically modified crops have been engineered for resistance to pathogens and herbicides and for better nutrient profiles. GM livestock have been developed, although as of November 2013 none were on the market.[4]
There is a scientific consensus[5][6][7][8] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[9][10][11][12][13] but that each GM food needs to be tested on a case-by-case basis before introduction.[14][15][16] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[17][18][19][20] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[21][22][23][24]
However, there are ongoing public concerns related to food safety, regulation, labelling, environmental impact, research methods, and the fact that some GM seeds are subject to intellectual property rights owned by corporations.[25]
Genetically modified foods, GM foods or genetically engineered foods, are foods produced from organisms that have had changes introduced into their DNA using the methods of genetic engineering as opposed to traditional cross breeding.[26][27] In the US, the Department of Agriculture (USDA) and the Food and Drug Administration (FDA) favor the use of "genetic engineering" over "genetic modification" as the more precise term; the USDA defines genetic modification to include "genetic engineering or other more traditional methods."[28][29]
According to the World Health Organization, "Genetically modified organisms (GMOs) can be defined as organisms (i.e. plants, animals or microorganisms) in which the genetic material (DNA) has been altered in a way that does not occur naturally by mating and/or natural recombination. The technology is often called 'modern biotechnology' or 'gene technology', sometimes also 'recombinant DNA technology' or 'genetic engineering'. ... Foods produced from or using GM organisms are often referred to as GM foods."[26]
Human-directed genetic manipulation of food began with the domestication of plants and animals through artificial selection at about 10,500 to 10,100 BC.[30]:1 The process of selective breeding, in which organisms with desired traits (and thus with the desired genes) are used to breed the next generation and organisms lacking the trait are not bred, is a precursor to the modern concept of genetic modification (GM).[30]:1[31]:1 With the discovery of DNA in the early 1900s and various advancements in genetic techniques through the 1970s[32] it became possible to directly alter the DNA and genes within food.
The first genetically modified plant was produced in 1983, using an antibiotic-resistant tobacco plant.[33] Genetically modified microbial enzymes were the first application of genetically modified organisms in food production and were approved in 1988 by the US Food and Drug Administration.[34] In the early 1990s, recombinant chymosin was approved for use in several countries.[34][35] Cheese had typically been made using the enzyme complex rennet that had been extracted from cows' stomach lining. Scientists modified bacteria to produce chymosin, which was also able to clot milk, resulting in cheese curds.[36]
The first genetically modified food approved for release was the Flavr Savr tomato in 1994.[2] Developed by Calgene, it was engineered to have a longer shelf life by inserting an antisense gene that delayed ripening.[37] China was the first country to commercialize a transgenic crop in 1993 with the introduction of virus-resistant tobacco.[38] In 1995, Bacillus thuringiensis (Bt) Potato was approved for cultivation, making it the first pesticide producing crop to be approved in the USA.[39] Other genetically modified crops receiving marketing approval in 1995 were: canola with modified oil composition, Bt maize, cotton resistant to the herbicide bromoxynil, Bt cotton, glyphosate-tolerant soybeans, virus-resistant squash, and another delayed ripening tomato.[2]
With the creation of golden rice in 2000, scientists had genetically modified food to increase its nutrient value for the first time.[40]
By 2010, 29 countries had planted commercialized biotech crops and a further 31 countries had granted regulatory approval for transgenic crops to be imported.[41] The US was the leading country in the production of GM foods in 2011, with twenty-five GM crops having received regulatory approval.[42] In 2015, 92% of corn, 94% of soybeans, and 94% of cotton produced in the US were genetically modified strains.[43]
The first genetically modified animal to be approved for food use was AquAdvantage salmon in 2015.[44] The salmon were transformed with a growth hormone-regulating gene from a Pacific Chinook salmon and a promoter from an ocean pout enabling it to grow year-round instead of only during spring and summer.[45]
In April 2016, a white button mushroom (Agaricus bisporus) modified using the CRISPR technique received de facto approval in the United States, after the USDA said it would not have to go through the agency's regulatory process. The agency considers the mushroom exempt because the editing process did not involve the introduction of foreign DNA.[46]
The most widely planted GMOs are designed to tolerate herbicides. By 2006 some weed populations had evolved to tolerate some of the same herbicides. Palmer amaranth is a weed that competes with cotton. A native of the southwestern US, it traveled east and was first found resistant to glyphosate in 2006, less than 10 years after GM cotton was introduced.[47][48][49]
Genetically engineered organisms are generated and tested in the laboratory for desired qualities. The most common modification is to add one or more genes to an organism's genome. Less commonly, genes are removed or their expression is increased or silenced or the number of copies of a gene is increased or decreased.
Once satisfactory strains are produced, the producer applies for regulatory approval to field-test them, called a "field release." Field-testing involves cultivating the plants on farm fields or growing animals in a controlled environment. If these field tests are successful, the producer applies for regulatory approval to grow and market the crop. Once approved, specimens (seeds, cuttings, breeding pairs, etc.) are cultivated and sold to farmers. The farmers cultivate and market the new strain. In some cases, the approval covers marketing but not cultivation.
According to the USDA, the number of field releases for genetically engineered organisms has grown from four in 1985 to an average of about 800 per year. Cumulatively, more than 17,000 releases had been approved through September 2013.[50]
Papaya was genetically modified to resist the ringspot virus. 'SunUp' is a transgenic red-fleshed Sunset papaya cultivar that is homozygous for the coat protein gene PRSV; 'Rainbow' is a yellow-fleshed F1 hybrid developed by crossing 'SunUp' and nontransgenic yellow-fleshed 'Kapoho'.[51] The New York Times stated, "in the early 1990s, Hawaiis papaya industry was facing disaster because of the deadly papaya ringspot virus. Its single-handed savior was a breed engineered to be resistant to the virus. Without it, the states papaya industry would have collapsed. Today, 80% of Hawaiian papaya is genetically engineered, and there is still no conventional or organic method to control ringspot virus."[52] The GM cultivar was approved in 1998.[53] In China, a transgenic PRSV-resistant papaya was developed by South China Agricultural University and was first approved for commercial planting in 2006; as of 2012 95% of the papaya grown in Guangdong province and 40% of the papaya grown in Hainan province was genetically modified.[54]
The New Leaf potato, a GM food developed using naturally occurring bacteria found in the soil known as Bacillus thuringiensis (Bt), was made to provide in-plant protection from the yield-robbing Colorado potato beetle.[55] The New Leaf potato, brought to market by Monsanto in the late 1990s, was developed for the fast food market. It was withdrawn in 2001 after retailers rejected it and food processors ran into export problems.[56]
As of 2005, about 13% of the Zucchini (a form of squash) grown in the US was genetically modified to resist three viruses; that strain is also grown in Canada.[57][58]
In 2011, BASF requested the European Food Safety Authority's approval for cultivation and marketing of its Fortuna potato as feed and food. The potato was made resistant to late blight by adding resistant genes blb1 and blb2 that originate from the Mexican wild potato Solanum bulbocastanum.[59][60] In February 2013, BASF withdrew its application.[61]
In 2013, the USDA approved the import of a GM pineapple that is pink in color and that "overexpresses" a gene derived from tangerines and suppress other genes, increasing production of lycopene. The plant's flowering cycle was changed to provide for more uniform growth and quality. The fruit "does not have the ability to propagate and persist in the environment once they have been harvested," according to USDA APHIS. According to Del Monte's submission, the pineapples are commercially grown in a "monoculture" that prevents seed production, as the plant's flowers aren't exposed to compatible pollen sources. Importation into Hawaii is banned for "plant sanitation" reasons.[62]
In 2014, the USDA approved a genetically modified potato developed by J.R. Simplot Company that contained ten genetic modifications that prevent bruising and produce less acrylamide when fried. The modifications eliminate specific proteins from the potatoes, via RNA interference, rather than introducing novel proteins.[63][64]
In February 2015 Arctic Apples were approved by the USDA,[65] becoming the first genetically modified apple approved for sale in the US.[66]Gene silencing is used to reduce the expression of polyphenol oxidase (PPO), thus preventing the fruit from browning.[67]
Corn used for food and ethanol has been genetically modified to tolerate various herbicides and to express a protein from Bacillus thuringiensis (Bt) that kills certain insects.[68] About 90% of the corn grown in the U.S. was genetically modified in 2010.[69] In the US in 2015, 81% of corn acreage contained the Bt trait and 89% of corn acreage contained the glyphosate-tolerant trait.[43] Corn can be processed into grits, meal and flour as an ingredient in pancakes, muffins, doughnuts, breadings and batters, as well as baby foods, meat products, cereals and some fermented products. Corn-based masa flour and masa dough are used in the production of taco shells, corn chips and tortillas.[70]
Genetically modified soybean has been modified to tolerate herbicides and produce healthier oils.[71] In 2015, 94% of soybean acreage in the U.S. was genetically modified to be glyphosate-tolerant.[43]
Starch or amylum is a polysaccharide produced by all green plants as an energy store. Pure starch is a white, tasteless and odourless powder. It consists of two types of molecules: the linear and helical amylose and the branched amylopectin. Depending on the plant, starch generally contains 20 to 25% amylose and 75 to 80% amylopectin by weight.[72]
Starch can be further modified to create modified starch for specific purposes,[73] including creation of many of the sugars in processed foods. They include:
Lecithin is a naturally occurring lipid. It can be found in egg yolks and oil-producing plants. it is an emulsifier and thus is used in many foods. Corn, soy and safflower oil are sources of lecithin, though the majority of lecithin commercially available is derived from soy.[74][75][76][pageneeded] Sufficiently processed lecithin is often undetectable with standard testing practices.[72][not in citation given] According to the FDA, no evidence shows or suggests hazard to the public when lecithin is used at common levels. Lecithin added to foods amounts to only 2 to 10 percent of the 1 to 5 g of phosphoglycerides consumed daily on average.[74][75] Nonetheless, consumer concerns about GM food extend to such products.[77][bettersourceneeded] This concern led to policy and regulatory changes in Europe in 2000,[citation needed] when Regulation (EC) 50/2000 was passed[78] which required labelling of food containing additives derived from GMOs, including lecithin.[citation needed] Because of the difficulty of detecting the origin of derivatives like lecithin with current testing practices, European regulations require those who wish to sell lecithin in Europe to employ a comprehensive system of Identity preservation (IP).[79][verification needed][80][pageneeded]
The US imports 10% of its sugar, while the remaining 90% is extracted from sugar beet and sugarcane. After deregulation in 2005, glyphosate-resistant sugar beet was extensively adopted in the United States. 95% of beet acres in the US were planted with glyphosate-resistant seed in 2011.[81] GM sugar beets are approved for cultivation in the US, Canada and Japan; the vast majority are grown in the US. GM beets are approved for import and consumption in Australia, Canada, Colombia, EU, Japan, Korea, Mexico, New Zealand, Philippines, Russian Federation and Singapore.[82] Pulp from the refining process is used as animal feed. The sugar produced from GM sugarbeets contains no DNA or proteinit is just sucrose that is chemically indistinguishable from sugar produced from non-GM sugarbeets.[72][83] Independent analyses conducted by internationally recognized laboratories found that sugar from Roundup Ready sugar beets is identical to the sugar from comparably grown conventional (non-Roundup Ready) sugar beets. And, like all sugar, sugar from Roundup Ready sugar beets contains no genetic material or detectable protein (including the protein that provides glyphosate tolerance).[84]
Most vegetable oil used in the US is produced from GM crops canola,[85]corn,[86][87]cotton[88] and soybeans.[89] Vegetable oil is sold directly to consumers as cooking oil, shortening and margarine[90] and is used in prepared foods. There is a vanishingly small amount of protein or DNA from the original crop in vegetable oil.[72][91] Vegetable oil is made of triglycerides extracted from plants or seeds and then refined and may be further processed via hydrogenation to turn liquid oils into solids. The refining process[92] removes all, or nearly all non-triglyceride ingredients.[93] Medium-chain triglycerides (MCTs) offer an alternative to conventional fats and oils. The length of a fatty acid influences its fat absorption during the digestive process. Fatty acids in the middle position on the glycerol molecules appear to be absorbed more easily and influence metabolism more than fatty acids on the end positions. Unlike ordinary fats, MCTs are metabolized like carbohydrates. They have exceptional oxidative stability, and prevent foods from turning rancid readily.[94]
Livestock and poultry are raised on animal feed, much of which is composed of the leftovers from processing crops, including GM crops. For example, approximately 43% of a canola seed is oil. What remains after oil extraction is a meal that becomes an ingredient in animal feed and contains canola protein.[95] Likewise, the bulk of the soybean crop is grown for oil and meal. The high-protein defatted and toasted soy meal becomes livestock feed and dog food. 98% of the US soybean crop goes for livestock feed.[96][97] In 2011, 49% of the US maize harvest was used for livestock feed (including the percentage of waste from distillers grains).[98] "Despite methods that are becoming more and more sensitive, tests have not yet been able to establish a difference in the meat, milk, or eggs of animals depending on the type of feed they are fed. It is impossible to tell if an animal was fed GM soy just by looking at the resulting meat, dairy, or egg products. The only way to verify the presence of GMOs in animal feed is to analyze the origin of the feed itself."[99]
A 2012 literature review of studies evaluating the effect of GM feed on the health of animals did not find evidence that animals were adversely affected, although small biological differences were occasionally found. The studies included in the review ranged from 90 days to two years, with several of the longer studies considering reproductive and intergenerational effects.[100]
Rennet is a mixture of enzymes used to coagulate milk into cheese. Originally it was available only from the fourth stomach of calves, and was scarce and expensive, or was available from microbial sources, which often produced unpleasant tastes. Genetic engineering made it possible to extract rennet-producing genes from animal stomachs and insert them into bacteria, fungi or yeasts to make them produce chymosin, the key enzyme.[101][102] The modified microorganism is killed after fermentation. Chymosin is isolated from the fermentation broth, so that the Fermentation-Produced Chymosin (FPC) used by cheese producers has an amino acid sequence that is identical to bovine rennet.[103] The majority of the applied chymosin is retained in the whey. Trace quantities of chymosin may remain in cheese.[103]
FPC was the first artificially produced enzyme to be approved by the US Food and Drug Administration.[34][35] FPC products have been on the market since 1990 and as of 2015 had yet to be surpassed in commercial markets.[104] In 1999, about 60% of US hard cheese was made with FPC.[105] Its global market share approached 80%.[106] By 2008, approximately 80% to 90% of commercially made cheeses in the US and Britain were made using FPC.[103]
In some countries, recombinant (GM) bovine somatotropin (also called rBST, or bovine growth hormone or BGH) is approved for administration to increase milk production. rBST may be present in milk from rBST treated cows, but it is destroyed in the digestive system and even if directly injected into the human bloodstream, has no observable effect on humans.[107][108][109] The FDA, World Health Organization, American Medical Association, American Dietetic Association and the National Institutes of Health have independently stated that dairy products and meat from rBST-treated cows are safe for human consumption.[110] However, on 30 September 2010, the United States Court of Appeals, Sixth Circuit, analyzing submitted evidence, found a "compositional difference" between milk from rBGH-treated cows and milk from untreated cows.[111][112] The court stated that milk from rBGH-treated cows has: increased levels of the hormone Insulin-like growth factor 1 (IGF-1); higher fat content and lower protein content when produced at certain points in the cow's lactation cycle; and more somatic cell counts, which may "make the milk turn sour more quickly."[112]
Genetically modified livestock are organisms from the group of cattle, sheep, pigs, goats, birds, horses and fish kept for human consumption, whose genetic material (DNA) has been altered using genetic engineering techniques. In some cases, the aim is to introduce a new trait to the animals which does not occur naturally in the species, i.e. transgenesis.
A 2003 review published on behalf of Food Standards Australia New Zealand examined transgenic experimentation on terrestrial livestock species as well as aquatic species such as fish and shellfish. The review examined the molecular techniques used for experimentation as well as techniques for tracing the transgenes in animals and products as well as issues regarding transgene stability.[113]
Some mammals typically used for food production have been modified to produce non-food products, a practice sometimes called Pharming.
A GM salmon, awaiting regulatory approval[114][115][116] since 1997,[117] was approved for human consumption by the American FDA in November 2015, to be raised in specific land-based hatcheries in Canada and Panama.[118]
The use of genetically modified food-grade organisms as recombinant vaccine expression hosts and delivery vehicles can open new avenues for vaccinology. Considering that oral immunization is a beneficial approach in terms of costs, patient comfort, and protection of mucosal tissues, the use of food-grade organisms can lead to highly advantageous vaccines in terms of costs, easy administration, and safety. The organisms currently used for this purpose are bacteria (Lactobacillus and Bacillus), yeasts, algae, plants, and insect species. Several such organisms are under clinical evaluation, and the current adoption of this technology by the industry indicates a potential to benefit global healthcare systems.[119]
There is a scientific consensus[120][121][122][123] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[124][125][126][127][128] but that each GM food needs to be tested on a case-by-case basis before introduction.[129][130][131] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[132][133][134][135]
Opponents claim that long-term health risks have not been adequately assessed and propose various combinations of additional testing, labeling[136] or removal from the market.[137][138][139][140] The advocacy group European Network of Scientists for Social and Environmental Responsibility (ENSSER), disputes the claim that "science" supports the safety of current GM foods, proposing that each GM food must be judged on case-by-case basis.[141] The Canadian Association of Physicians for the Environment called for removing GM foods from the market pending long term health studies.[137] Multiple disputed studies have claimed health effects relating to GM foods or to the pesticides used with them.[142]
The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[143][144][145][146] Countries such as the United States, Canada, Lebanon and Egypt use substantial equivalence to determine if further testing is required, while many countries such as those in the European Union, Brazil and China only authorize GMO cultivation on a case-by-case basis. In the U.S. the FDA determined that GMO's are "Generally Recognized as Safe" (GRAS) and therefore do not require additional testing if the GMO product is substantially equivalent to the non-modified product.[147] If new substances are found, further testing may be required to satisfy concerns over potential toxicity, allergenicity, possible gene transfer to humans or genetic outcrossing to other organisms.[26]
Government regulation of GMO development and release varies widely between countries. Marked differences separate GMO regulation in the U.S. and GMO regulation in the European Union.[148] Regulation also varies depending on the intended product's use. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.[149]
In the U.S., three government organizations regulate GMOs. The FDA checks the chemical composition of organisms for potential allergens. The United States Department of Agriculture (USDA) supervises field testing and monitors the distribution of GM seeds. The United States Environmental Protection Agency (EPA) is responsible for monitoring pesticide usage, including plants modified to contain proteins toxic to insects. Like USDA, EPA also oversees field testing and the distribution of crops that have had contact with pesticides to ensure environmental safety.[150][bettersourceneeded] In 2015 the Obama administration announced that it would update the way the government regulated GM crops.[151]
In 1992 FDA published "Statement of Policy: Foods derived from New Plant Varieties." This statement is a clarification of FDA's interpretation of the Food, Drug, and Cosmetic Act with respect to foods produced from new plant varieties developed using recombinant deoxyribonucleic acid (rDNA) technology. FDA encouraged developers to consult with the FDA regarding any bioengineered foods in development. The FDA says developers routinely do reach out for consultations. In 1996 FDA updated consultation procedures.[152][153]
As of 2015, 64 countries require labeling of GMO products in the marketplace.[154]
US and Canadian national policy is to require a label only given significant composition differences or documented health impacts, although some individual US states (Vermont, Connecticut and Maine) enacted laws requiring them.[155][156][157][158] In July 2016, Public Law 114-214 was enacted to regulate labeling of GMO food on a national basis.
In some jurisdictions, the labeling requirement depends on the relative quantity of GMO in the product. A study that investigated voluntary labeling in South Africa found that 31% of products labeled as GMO-free had a GM content above 1.0%.[159]
In Europe all food (including processed food) or feed that contains greater than 0.9% GMOs must be labelled.[160]
Testing on GMOs in food and feed is routinely done using molecular techniques such as PCR and bioinformatics.[161]
In a January 2010 paper, the extraction and detection of DNA along a complete industrial soybean oil processing chain was described to monitor the presence of Roundup Ready (RR) soybean: "The amplification of soybean lectin gene by end-point polymerase chain reaction (PCR) was successfully achieved in all the steps of extraction and refining processes, until the fully refined soybean oil. The amplification of RR soybean by PCR assays using event-specific primers was also achieved for all the extraction and refining steps, except for the intermediate steps of refining (neutralisation, washing and bleaching) possibly due to sample instability. The real-time PCR assays using specific probes confirmed all the results and proved that it is possible to detect and quantify genetically modified organisms in the fully refined soybean oil. To our knowledge, this has never been reported before and represents an important accomplishment regarding the traceability of genetically modified organisms in refined oils."[162]
According to Thomas Redick, detection and prevention of cross-pollination is possible through the suggestions offered by the Farm Service Agency (FSA) and Natural Resources Conservation Service (NRCS). Suggestions include educating farmers on the importance of coexistence, providing farmers with tools and incentives to promote coexistence, conduct research to understand and monitor gene flow, provide assurance of quality and diversity in crops, provide compensation for actual economic losses for farmers.[163]
The genetically modified foods controversy consists of a set of disputes over the use of food made from genetically modified crops. The disputes involve consumers, farmers, biotechnology companies, governmental regulators, non-governmental organizations, environmental and political activists and scientists. The major disagreements include whether GM foods can be safely consumed, harm the environment and/or are adequately tested and regulated.[138][164] The objectivity of scientific research and publications has been challenged.[137] Farming-related disputes include the use and impact of pesticides, seed production and use, side effects on non-GMO crops/farms,[165] and potential control of the GM food supply by seed companies.[137]
The conflicts have continued since GM foods were invented. They have occupied the media, the courts, local, regional and national governments and international organizations.
The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.
Domingo, Jos L.; Bordonaba, Jordi Gin (2011). "A literature review on the safety assessment of genetically modified plants" (PDF). Environment International. 37: 734742. doi:10.1016/j.envint.2011.01.003. PMID21296423. In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as the respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents a notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies.
Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment" (PDF). Science, Technology, & Human Values. 40: 132. doi:10.1177/0162243915598381. I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.
And contrast:
Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology: 15. doi:10.3109/07388551.2015.1130684. ISSN0738-8551. PMID26767435. Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.
The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality.
and
Yang, Y.T.; Chen, B. (2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture. 96: 18511855. doi:10.1002/jsfa.7523. PMID26536836. It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011).
Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food... Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.
Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.
Pinholster, Ginger (October 25, 2012). "AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers"". American Association for the Advancement of Science. Retrieved February 8, 2016.
"REPORT 2 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH (A-12): Labeling of Bioengineered Foods" (PDF). American Medical Association. 2012. Retrieved March 19, 2016. Bioengineered foods have been consumed for close to 20 years, and during that time, no overt consequences on human health have been reported and/or substantiated in the peer-reviewed literature.
GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.
"Genetically modified foods and health: a second interim statement" (PDF). British Medical Association. March 2004. Retrieved March 21, 2016. In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.
When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.
Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.
The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.
The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.
Domingo, Jos L.; Bordonaba, Jordi Gin (2011). "A literature review on the safety assessment of genetically modified plants" (PDF). Environment International. 37: 734742. doi:10.1016/j.envint.2011.01.003. PMID21296423. In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as the respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents a notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies.
Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment" (PDF). Science, Technology, & Human Values. 40: 132. doi:10.1177/0162243915598381. I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.
And contrast:
Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology: 15. doi:10.3109/07388551.2015.1130684. ISSN0738-8551. PMID26767435. Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.
The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality.
and
Yang, Y.T.; Chen, B. (2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture. 96: 18511855. doi:10.1002/jsfa.7523. PMID26536836. It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011).
Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food... Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.
Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.
Pinholster, Ginger (October 25, 2012). "AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers"". American Association for the Advancement of Science. Retrieved February 8, 2016.
"REPORT 2 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH (A-12): Labeling of Bioengineered Foods" (PDF). American Medical Association. 2012. Retrieved March 19, 2016. Bioengineered foods have been consumed for close to 20 years, and during that time, no overt consequences on human health have been reported and/or substantiated in the peer-reviewed literature.
GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.
"Genetically modified foods and health: a second interim statement" (PDF). British Medical Association. March 2004. Retrieved March 21, 2016. In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.
When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.
Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.
The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.
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Genetically modified food - Wikipedia
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Free genetic engineering Essays and Papers – 123helpme
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Title Length Color Rating The Effects of Genetic Engineering on Agriculture - Genetic engineering is a way in which specific genes for an animal or plant can be extracted, and reproduced to form a new animal or plant. These new organisms will express the required trait for that gene. This practice is a very controversial topic within the scientific world. It is being implemented in various areas such as agriculture even though there are many alternatives that can be found for genetic engineered crops, such as organic materials and reducing leeching of the soil. The controversy regarding this practice occurs as it is believed to contribute both negative and positive implications and dangers, not only to oneself but the environment as a whole.... [tags: Genetic Engineering ] :: 5 Works Cited 1303 words (3.7 pages) Strong Essays [preview] Pros and Cons of Genetic Engineering - Genetic Engineering is highly controversial since some people believe that genetic engineering is playing God. 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[tags: Genetic Engineering ] :: 7 Works Cited 1806 words (5.2 pages) Term Papers [preview] Genetic Engineering in Humans - Author Chuck Klosterman said, The simple truth is that were all already cyborgs more or less. Our mouths are filled with silver. Our nearsighted pupils are repaired with surgical lasers. We jam diabetics full of delicious insulin. Almost 40 percent of Americans now have prosthetic limbs. We see to have no qualms about making post-birth improvements to our feeble selves. Why are we so uncomfortable with pre-birth improvement? Despite Klostermans accurate observation, there are reasons people are wearisome toward pre-birth enhancement.... [tags: Genetic Engineering ] 859 words (2.5 pages) Better Essays [preview] Genetic Engineering: The Impact of Human Manipulation - The scenes of a science fiction movie show presumably unrealistic scientific inventions. 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This was a major discovery that trickles down to the modern era of Genetics. Current scientists have pioneered new ways to decode human DNA, beating the $3 billion government-run Genome project to its goal.... [tags: Genetic Engineering ] :: 10 Works Cited 1335 words (3.8 pages) Strong Essays [preview] Human Genetic Engineering in Beneficial to Society - Even after thousands of years of evolution, the human race is not perfect: it is ravaged by disease and limited by nature. Yet, in recent times, researchers have begun to ascertain an advanced understanding of the underlying genetic code of humanity. The Human Genome Project, now complete, has provided a map of the intricacies in human DNA, allowing researchers to begin looking at the purpose of each gene. When combined with selective embryo implantation, which is used occasionally today to avoid hereditary diseases or to choose gender, genetic discoveries can become a sort of artificial evolution.... [tags: Pro Human Genetic Engineering] :: 8 Works Cited 1484 words (4.2 pages) Powerful Essays [preview] Genetic Engineering - Just imagine the scene: and newlywed wife and husband are sitting down with a catalog, browsing joyously, pointing and awing at all the different options, fantasizing about all the possibilities that could become of their future. Is this a catalog for new furniture. No. This catalog for all features, phenotype and genotype, for the child they are planning to have. It is basically a database for parents to pick and choose all aspects of their children, from the sex of the child, to looks, and even to personality traits.... [tags: Genetic Engineering] 1131 words (3.2 pages) Good Essays [preview] Genetic Engineering - Genes are, basically, the blueprints of our body which are passed down from generation to generation. 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If engineering of this caliber were to be used for anything other than the advancement of the human race, the effects could be devastating. If precautions are not implemented on this science, parents might use it solely for eugenic purposes.... [tags: Genetic Engineering Essays] 773 words (2.2 pages) Better Essays [preview] Genetic Engineering: The Next Technological Leap or a Disruption to the Natural Order of Our Planet? - While walking down the produce aisle at your local grocery store, have you ever questioned where the assortment of goods came from. When asked, perhaps your first thought would likely be from a local farm or orchard. But what if I were to tell you that those very goods could in fact be from a far less obvious third choice. What if someone told you that those pretty peaches on display were meticulously grown in a laboratory to bring forth predetermined traits. As futuristic as it may sound, this type of technology is no longer science fiction but has become a new reality.... [tags: Genetic Engineering ] :: 3 Works Cited 936 words (2.7 pages) Better Essays [preview] The Need for Policy Makers to Regulate Human Genetic Engineering - Human genetic engineering (HGE), a prevalent topic for scientists in research, is the process of manipulating genes in the human genome. Potentially, scientists can use the process of HGE to alter many biological and psychological human traits by gene modification. Currently, however, there is a large deficiency in information regarding HGE and its effects to the human body; creating a need for scientists to conduct more research and tests. Because of the many unknowns involving HGE it is necessary for policy makers to regulate HGE for the use by scientists.... [tags: Human Genetic Engineering] :: 2 Works Cited 1249 words (3.6 pages) Strong Essays [preview] The Pros and Cons of Genetic Engineering - Genetic engineering is a process in which scientists transfer genes from one species to another totally unrelated species. Usually this is done in order to get one organism to produce proteins, which it would not naturally produce. The genes taken from one species, which code for a particular protein, are put into cells of another species, using a vector. This can result in the cells producing the desired protein. It is used for producing proteins which can be used by humans, such as insulin for diabetics and is also used to make organisms better at surviving, for example genetically modifying a plant so that it can survive in acidic soil.... [tags: Genetic Engineering Essays] 1054 words (3 pages) Better Essays [preview] Genetic Engineering: The Controversy of Genetic Screening - The Controversy of Genetic Screening Craig Ventor of Celera Genomics, Rockville, MD, and Francis Collins of the National Institutes of Health and Wellcome Trust, London, England, simultaneously presented the sequence of human DNA in June of 2000, accomplishing the first major endeavor of the Human Genome Project (HGP) (Ridley 2). As scientists link human characteristics to genes-segments of DNA found on one or more of the 23 human chromosomes-prospects for genetic engineering will increase dramatically.... [tags: Genetic Engineering Essays] :: 4 Works Cited 1609 words (4.6 pages) Powerful Essays [preview] An Enhanced Genotype: Ethical Issues Involved with Genetic Engineering and their Impact as Revealed by Brave New World - An Enhanced Genotype: Ethical Issues Involved with Genetic Engineering and their Impact as Revealed by Brave New World Human society always attempts to better itself through the use of technology. Thus far, as a species, we have already achieved much: mastery of electronics, flight, and space travel. However, the field in which the most progress is currently being made is Biology, specifically Genetic Engineering. In Aldous Huxleys Brave New World, humanity has taken control of reproduction and biology in the same way that we have mastered chemistry and physics.... [tags: Genetic Engineering ] :: 6 Works Cited 2288 words (6.5 pages) Term Papers [preview] The Benefits of Genetic Engineering - Outline I. Thesis statement: The benefits of genetic engineering far outweigh its potential for misuse. II. Genetic Engineering A. Definition of Genetic Engineering. (#6) B. Who invented Genetic Engineering Gregor Mendel (Christopher Lampton #7) Thomas Hunt Morgan (Christopher Lampton #7) III. Benefits of Genetic Engineering A. Genetic Screening (Laurence E. Karp #4) B. Gene Therapy (Renato Dulbecco #6) C. Cloning D. Genetic Surgery (Christopher Lampton #7) E. Benefits in Agriculture (David Pimentel and Maurizio G.... [tags: Genetic Engineering Research Papers] :: 15 Works Cited 2500 words (7.1 pages) Strong Essays [preview] The Benefits of Genetic Engineering - The selective Engineering of Genetics is invaluable to the health and happiness of humans. The importance of this issue has played second fiddle to the arguments, for and against genetic engineering. This essay will discuss the impact of genetic engineering on everyday life, for example genetic disorders, disease and how its impact on life in the world today. Although the opinions differ greatly, the benefits are substantial. Firstly, an increasing importance is being placed on the role of genetic engineering in the use of riding the incidence of genetic disorders.... [tags: Genetic Engineering Essays] :: 8 Works Cited 1176 words (3.4 pages) Strong Essays [preview] The Benefits of Genetic Engineering - What exactly is genetic engineering. A simple definition of genetic engineering is the ability to isolate DNA pieces that contain selected genes of other species(Muench 238). Genetic engineering has been the upcoming field of biology since the early nineteen seventies. The prosperous field has benefits for both the medical and also the agricultural field. The diminishing of diseases, especially congenital disorders, reduction of pollution, eradication of world hunger, and increased longevity are just some of the possibilities which scientists foresee.... [tags: Genetic Engineering Essays] 1146 words (3.3 pages) Strong Essays [preview] Genetic Engineering Is Not Ethical - For many years, genetic engineering has been a topic in heated debates. Scientists propose that genetic engineering far outweighs its risks in benefits and should be further studied. Politicians argue that genetic engineering is largely unethical, harmful, and needs to have strong limitations. Although genetic engineering may reap benefits to modern civilization, it raises questions of human ethics, morality, and the limitations we need to set to protect humanity. Though there is harsh criticism from politicians, scientists continue to press forward saying that genetic engineering is of utmost importance to help and improve society.... [tags: Genetic Engineering is Immoral ] :: 5 Works Cited 1490 words (4.3 pages) Strong Essays [preview] Is Genetic Engineering Ethically Correct? - Over the past few years, genetic engineering has come a long way from its roots. What spawned as just a project for understanding has now become quite powerful. An article written by Michael Riess aided me in gaining some knowledge of the ethical dilemmas faced in the field of genetic engineering. Suppose you and your partner both discover that you are carriers of a genetic defect known as cystic fibrosis, and the two of you are expecting a baby. Genetic screening gives you the opportunity to use antenatal diagnosis to see if the baby will have cystic fibrosis or not (Reiss).... [tags: Genetic Engineering Essays] :: 2 Works Cited 715 words (2 pages) Strong Essays [preview] The Benefits of Genetic Engineering - The engineering of deoxyribonucleic acid (DNA) is entirely new, yet genetics, as a field of science, has fascinated mankind for over 2,000 years. Man has always tried to bend nature around his will through selective breeding and other forms of practical genetics. Today, scientists have a greater understanding of genetics and its role in living organisms. Unfortunately, some people are trying to stop further studies in genetics, but the research being conducted today will serve to better mankind tomorrow.... [tags: Genetic Engineering Essays] 1109 words (3.2 pages) Strong Essays [preview] The Benefits of Genetic Engineering - Many people are envied or deprecated because of certain traits they are born with. Those that are envied are a select few, which in turn is why they are envied. When one child in a nursery has a toy, he is coveted by all the other children in the nursery. He will be idolized, and nearly every child will want to be his friend. However, there will also those that want the toy for themselves. The children that are jealous will do whatever they can to get the toy. The jealous children often resort to violence, and this is true in all aspects of life.... [tags: Genetic Engineering Essays] 975 words (2.8 pages) Strong Essays [preview] Genetic Engineering and the Media - Genetic engineering and its related fields have stimulated an extremely controversial scientific debate about cloning for the last decade. With such a wide range of public opinions, it is hard to find any middle ground. Some feel that improving the genes of future children will help mankind make a major evolutionary step forward. Others agree that there could be dangerous unforeseen consequences in our genetic futures if we proceed with such endeavors. A third group warns that the expense of genetic enhancement will further separate the wealthy from the poor and create a super race. Popular magazines and the Internet are two of the major arenas in which this debate has been hotly cont... [tags: Genetic Engineering Essays] :: 21 Works Cited 1731 words (4.9 pages) Powerful Essays [preview] The FDA Should Prohibit Genetic Engineering - Abstract: Recent developments in genomic research have enabled humans to manipulate the genes of living organisms with genetic engineering. Scientists have used this momentous technology in environmental and most recently, agricultural spheres. However, the United States Food and Drug Administration (FDA) does not require that genetically altered foods be labeled as such. As a result, there is no protection against humans' ability to construct organisms that nature never intended to exist and to threaten nature's carefully balanced environment. Is it ethically responsible for the government to allow scientists to continue with these advances if they do not understand their consequences.... [tags: Genetic Engineering, Genetic Ethics] :: 10 Works Cited 2439 words (7 pages) Powerful Essays [preview] Genetic Engineering is Immoral - Genetic engineering gives the power to change many aspects of nature and could result in a lot of life-saving and preventative treatments. Today, scientists have a greater understanding of genetics and its role in living organisms. However, if this power is misused, the damage could be very great. Therefore, although genetic engineering is a field that should be explored, it needs to be strictly regulated and tested before being put into widespread use. Genetic engineering has also, opened the door way to biological solutions for world problems, as well as aid for body malfunctions.... [tags: Genetic Engineering Essays] 423 words (1.2 pages) Strong Essays [preview] Genetic Engineering is Unethical - Just as the success of a corporate body in making money need not set the human condition ahead, neither does every scientific advance automatically make our lives more meaningful'; (Wald 45). These words were spoken by a Nobel Prize winning biologist and Harvard professor, George Wald, in a lecture given in 1976 on the Dangers of Genetic Engineering. This quotation states that incredible inventions, such as genetic engineering, are not always beneficial to society. Genetic engineering is altering the genetic material of cells and/or organisms in order to make them capable of making new substances or performing new functions'; (Wald 45).... [tags: Genetic Engineering is Immoral] :: 3 Works Cited 1141 words (3.3 pages) Better Essays [preview] Genetic Engineering is Unethical - Genetic engineering is a technology that has been created to alter DNA of different species to try and make them more improved. This essay will discuss the eugenics, the religious point of view about genetic engineering, genetically modified food and the genetic screening of embryos. In this essay it will be said wether genetic engineering is ethical or unethical. During 1924 Hitler said that everyone needs to be blond hair, blue eyes and white. This is known as Eugenics, thanks to a new science known as biotechnology in a few decades.... [tags: Genetic Engineering Essays] 492 words (1.4 pages) Strong Essays [preview] Genetic Engineering: Playing God - Current technology has made what once seemed impossible, mapping the human genome, a reality within the next decade. What began over forty years ago with the discovery of the basic structure of DNA has evolved into the Human Genome Project. This is a fifteen-year, three billion dollar effort to sequence the entire human genetic code. The Project, under the direction of the U.S. National Institute of Health and the department of Energy is ahead of schedule in mapping what makes up an individual's genetic imprint.... [tags: Genetic Engineering Essays] 634 words (1.8 pages) Strong Essays [preview] Genetic Engineering: Playing God - Regenerating extinct species, engineering babies that are born without vital body organs, this is what the use of genetic engineering brings to the world. In Greek myth, an chimera was a part lion, part goat, part dragon that lived in Lycia; in real life, its an animal customized with genes of different species. In reality, it could be a human-animal mixture that could result in horror for the scientific community. In myth the chimera was taken down by the warrior Bellerophon, the biotech version faces platoons of lawyers, bioethicists, and biologists (Hager).... [tags: Genetic Engineering Essays] :: 8 Works Cited 1804 words (5.2 pages) Strong Essays [preview] Genetic Engineering Research Paper - I. Introduction In the past three decades, scientists have learned how to mix and match characteristics among unrelated creatures by moving genes from one creature to another. This is called genetic engineering. Genetic Engineering is prematurely applied to food production. There are estimates that food output must increase by 60 percent over the next 25 years to keep up with demand. Thus, the result of scientist genetically altering plants for more consumption. The two most common methods for gene transfer are biological and electromechanical.... [tags: Science Biology Genetic Engineering Essays] :: 3 Works Cited 1347 words (3.8 pages) Strong Essays [preview] Human Genetic Engineering: Unnatural Selection - Introduction Technology has a significant influence across the world, as it has become a fast growing field. Modern biotechnology has been in the major forefront of this influence. From the discovery of DNA to the cloning of various animals, the study of genetic engineering has changed the way society views life. However, does genetic engineering have the capacity to influence the world to its best abilities. Products, which are genetically engineered, may cause severe negative effects on our society.... [tags: Genetic Engineering Essays] :: 3 Works Cited 1509 words (4.3 pages) Strong Essays [preview] Genetic Engineering - At the Roslin Institute in Edinburgh, Scotland, Dr. Keith Campbell, director of embryology at PPL therapeutics in Roslin, and his colleague Dr. Ian Wilmut worked together on a project to clone a sheep, Dolly, from adult cells. On February 22, 1997, they finally succeeded. Dolly was the only lamb born from 277 fusions of oocytes with udder cells. Wilmut says there were so many failures because it is difficult to ensure that the empty oocytes and the donor cell are at the same stage of the cell division cycle.To clone Dolly, basically scientists took an unfertilized egg cell, removed the nucleus, replaced it with cells taken from the organism to be cloned, put it into an empty egg cell which... [tags: Genetic Engineering Essays] 1446 words (4.1 pages) Strong Essays [preview] Genetic Engineering: Our Key to a Better World - What is genetic engineering one might ask and why is there so much moral controversy surrounding the topic. Genetic engineering as defined by Pete Moore, "is the name given to a wide variety of techniques that have one thing in common: they all allow the biologist to take a gene from one cell and insert it into another" (SS1). Such techniques included in genetic engineering (both "good" and "bad") are, genetic screening both during the fetal stage and later in life, gene therapy, sex selection in fetuses, and cloning.... [tags: Genetic Engineering Essays] :: 3 Works Cited 1117 words (3.2 pages) Better Essays [preview] Genetic Engineering and Cryonic Freezing: A Modern Frankenstein? - Genetic Engineering and Cryonic Freezing: A Modern Frankenstein. In Mary Shelley's Frankenstein, a new being was artificially created using the parts of others. That topic thus examines the ethics of "playing God" and, though written in 1818, it is still a relevant issue today. Genetic engineering and cryogenic freezing are two current technologies related to the theme in the novel of science transcending the limits of what humans can and should do. Genetic engineering is widely used today.... [tags: Genetic Engineering Essay Examples] :: 5 Works Cited 1507 words (4.3 pages) Powerful Essays [preview] Genetic Engineering: The Tremendous Benefits Outweigh the Risks - Wouldn't it be great to improve health care, improve agriculture, and improve our quality of life. Genetic engineering is already accomplishing those things, and has the potential to accomplish much more. Genetic engineering, also referred to as biotechnology, is a fairly new science where the genes of an organism are modified to change the features of an organism or group of organisms. Genes are found in the DNA (deoxyribonucleic acid) of an organism, and each gene controls a specific trait of an organism.... [tags: Genetic Engineering Essay Examples] :: 7 Works Cited 2253 words (6.4 pages) Powerful Essays [preview] Genetic Engineering Brings More Harm Than Good - Until the recent demise of the Soviet Union, we lived under the daily threat of nuclear holocaust extinguishing human life and the entire biosphere. Now it looks more likely that total destruction will be averted, and that widespread, but not universally fatal, damage will continue to occur from radiation accidents from power plants, aging nuclear submarines, and perhaps the limited use of tactical nuclear weapons by governments or terrorists. What has gone largely unnoticed is the unprecedented lethal threat of genetic engineering to life on the planet.... [tags: Genetic Engineering Essays] 1953 words (5.6 pages) Strong Essays [preview] Genetic Engineering New Teeth - The article I read was about some scientists that were able to grow teeth inside rats bodies. This project was led by Pamela C. Yelick, a scientist for Forsyth Institute, and the project was conducted in Massachusetts. Joseph P. Vacanti, a tissue engineer at Massachusetts General Hospital, and Yelick had the idea for the experiment. Vacanti had previously worked with rats and he found that cells will naturally organize themselves into tissues and other complex structures if they are placed in the right environment.... [tags: Genetic Engineering Essays] 736 words (2.1 pages) Strong Essays [preview] Ethics of Human Cloning and Genetic Engineering - INTRODUCTION When the Roslin Institute's first sheep cloning work was announced in March 1996 the papers were full of speculation about its long-term implications. Because of this discovery, the medias attention has focused mainly on discussion of the possibility, of cloning humans. In doing so, it has missed the much more immediate impact of this work on how we use animals. It's not certain this would really lead to flocks of cloned lambs in the fields of rural America, or clinically reproducible cuts of meat on the supermarket shelves.... [tags: Genetic Engineering Essays] :: 9 Works Cited 1845 words (5.3 pages) Strong Essays [preview] We Must Educate Ourselves Before Passing Laws Restricting Cloning and Genetic Engineering - Biotechnology and genetic engineering involve the cloning of animal cells and organisms, but they also involve the alteration of an organism in an effort to make it more perfect, whether it is a crop, an animal, or even a human being. Obviously the cloning of humans or the cloning of human cells is much different than the cloning of genetically superior livestock or a better quality, higher yielding food crop, and people throughout the world realize this. The cloning of human beings has become one of the worst fears in our society today and for that reason many laws have been passed throughout European countries and North America in an effort to ban human cloning.... [tags: Genetic Engineering Essays] :: 4 Works Cited 1937 words (5.5 pages) Powerful Essays [preview] The Benefits of Human Genetic Engineering - Pre-implantation genetic diagnosis is a revolutionary procedure that utilizes in vitro fertilization to implant a healthy egg cell into the mothers uterus after it is screened for mutations or other abnormalities. That way, only healthy eggs can develop to term and become beautiful, bouncing boys or girls. Designer babies have a bright future in the face of science because they are genetically engineered to be: disease free; viable donors for a sibling or parent; and with optional elimination of any severe cosmetic disorders that might develop,without risk to human diversity in the future.... [tags: Pre-implantation genetic diagnosis, PGD] :: 6 Works Cited 1650 words (4.7 pages) Powerful Essays [preview] Genetic Engineering The Perfect Child - Modern society has an unquestionable preoccupation with perfection. Indulging in our vanities with things such as plastic surgery, veneers, botox, collagen, hair dye, and so on, have become a part of the socially acceptable norm. People do these things, and more, in an attempt to become their ideal selves. However, many are taking these practices to a completely new extreme, and are not stopping at just altering their own physical characteristics. With recent advances in medical science and technology, couples are now able to genetically modify embryos to create their ideal children.... [tags: Pre-Implantation Genetic Diagnosis] :: 2 Works Cited 1022 words (2.9 pages) Strong Essays [preview] The Morals and Ethics of Genetic Engineering - Introduction Widely considered a revolutionary scientific breakthrough, genetic engineering has been on a path toward changing the world since its introduction in 1973 by Stanley Cohen and Herbert Boyer (What). However, as genetic engineering slowly permeates the lives of humanity, the morals and ethics behind what are now common practices are entering public attention, and as a culture we are left to question whether the change brought on by such a discovery bring benefits and positive change, or damage and destruction.... [tags: genetics, theology, bioethics, DNA, GMOs] :: 13 Works Cited 3322 words (9.5 pages) Research Papers [preview] The Human Genetic Engineering Debate - Science is moving forward at an increasing rate every day. Just in the past decade, there have been numerous new discoveries in astronomy, chemistry, geology, paleontology, and many more scientific fields. However, some of the fastest growing subjects are in the field of biological sciences, more specifically genetics. Over the past twenty years a new genetic science known as genetic engineering has come to prominence. Genetic engineering is the direct manipulation of an organisms genome using biotechnology, including a humans genome.... [tags: Genetics, Science Ethics] :: 9 Works Cited 1838 words (5.3 pages) Better Essays [preview] Genetic Engineering in the Modern World - Advances in biotechnology can be looked at two ways; both, positive and negative. People can also differ in what would qualify as a positive and negative way. Some may think that tinkering with Deoxyribonucleic acid also know as DNA, should not be allowed at all for any reason. Others may believe that manipulating human DNA can have many different beneficial outcomes. Biotechnology and genetic engineering can be looked at in two very different ways; can either be misused or unethical or it can be beneficial, ethical, and used for the better kind.... [tags: biotechnology, DNA, abortion] :: 1 Works Cited 966 words (2.8 pages) Better Essays [preview] Genetic Engineering and the Pursuit of Perfection - Research Paper Rough Draft In the year 2050, a young boy nervously rehearses what hes going to say as he approaches the cheerleader hes been too nervous to approach for the past month. But as he draws near, a jock pushes his books out of his hands. Hes teased, being the school wimp. They call him names like undesirable, god-child, and in-valid. Of course nobody cares for a less-than-perfect child whose genetic makeup was left to fate. With the introduction of genetic engineering into society, people like this young boy simply have no hope for competing against the likes of the genetically reimagined, perfect jock, people engineered to be unflawed.... [tags: Perfection, Body Image, Technology] :: 10 Works Cited 1898 words (5.4 pages) Powerful Essays [preview] Genetic Engineering: Pros and Cons - Our world has finally begun its long-predicted descent into the depths of chaos. We may not yet realize it, but more and more problems plague the very state of our humanity with each passing day, such as cancer, famine, genetic disorders, and social elitism. It seems as though there is little hope, although a new solution has finally emerged, in the form of genetic engineering. It is apparent, however, that currently we cannot proceed, because while there are an abundant amount of advantages to genetic engineering, it is not a utopian process; criticism includes its practicality, theological implications, and changes in modern social structure.... [tags: Eugenics, Ethics] :: 5 Works Cited 1212 words (3.5 pages) Strong Essays [preview] Is Genetic Engineering Ethically Right? - Described at its most simple, ethics can be described as a socially constructed set of behaviours and beliefs deemed either acceptable or unacceptable by the vast majority of people. Ethical beliefs can vary somewhat from person to person and are ever changing and malleable (www.ncbi.nlm.gov/pubmed/15289521). There are three main ethical theories used by present day philosophers; these are Meta-ethics, Normative ethics and Applied ethics. Meta-ethics focuses on the nature of moral judgement and the foundation of ethical principles.... [tags: DNA, gene, diabetis] :: 10 Works Cited 1191 words (3.4 pages) Strong Essays [preview] Genetic Engineering and the Public - Genetic Engineering and the Publics Uses of Genetic Engineering Opinions about genetic engineering range from disgust to awe. These opinions may also depend on what type of animal is being genetically manipulated, how such manipulation is being done, and for what reasons. In California, pet fish that have been genetically altered to fluoresce (glofish) have been restricted for sale.[1] Yet, for the rest of the United States these fish are found in several species, varieties and morphs. In California, Commissioner of Californias Fish and Game, Sam Schuchat, felt that there was a difference in genetic modification depending on the use of the product made.[2] The use of genetic engineering f... [tags: Stake Holders, Science, Dialogue] :: 6 Works Cited 877 words (2.5 pages) Better Essays [preview] Genetic Engineering: A Good Thing? - Today there are many definitions of Genetic Engineering, such as Genetic Engineering is a laboratory technique used by scientists to change the DNA of living organisms (Kowalski) and Genetic Engineering refers to the modification or manipulation of a living organisms genes (Genetic). No matter the wording all definitions of genetic engineering refers to somehow changing an organisms genetic identity. Many people today support genetic engineering because it has many potential benefits for today's society; however, it also has many potential threats associated with it.... [tags: argumentative, persuasive, informative] :: 19 Works Cited 1928 words (5.5 pages) Powerful Essays [preview] Genetic Engineering and its Drawbacks - In the past few years, there have been numerous technological advances, one of them being genetic engineering. Scientists are experimenting with genes and animals to create everything from a Day-Glo pet fish to a pig whose liver could be used in a liver transplant for humans. Scientists argue that genetic engineering can be used to test medicinal products without putting humans at risk, to battle diseases and to make a body with a stronger immune system, amongst many other reasons, which they claim are to improve the outcome of the human race.... [tags: gene, transplant, animal testing] :: 9 Works Cited 911 words (2.6 pages) Better Essays [preview] The Perfect Child: Genetic Engineering - Have you ever wondered what it would be like if you could produce the perfect child. You picked their eye color, hair color, body type, even intelligence level. Instead of waiting nine months to see what your child looks like; you will already know because you chose their outer appearance. Improvements in science, has given way to the idea of allowing people to choose their offsprings physical attributes. This new concept is known as designer babies. A designer baby according to the oxford dictionary is a baby whose genetic makeup has been artificially selected by genetic engineering, combined with in vitro fertilization to ensure the presence or absence of particular genes or characteris... [tags: Designer Babies, Stem Cells] :: 5 Works Cited 899 words (2.6 pages) Better Essays [preview] Cons of Genetic Modification of Plants - In our everyday lives we have a substantial need for food. Everyone on planet earth needs food to survive from day to day, so engineers have begun mutating plants and crops to create a better source of nutrition to the population. Scientists are pushing the boundaries in order to create the most bountiful crops and, in turn, healthier people. Imagine what could happen if there were larger harvests, more succulent fruits and nutritious vegetables. Our imagination can run wild with the endless possibilities of genetic alteration of food.... [tags: Genetic Engineering ] :: 5 Works Cited 1011 words (2.9 pages) Strong Essays [preview] Germline Engineering and Reprogenetic Technologies - Modern technologies are constantly advancing in a multitude of ways to the degree that scientists have gained enough knowledgeable about the human genome to be able to find specific genes during the embryonic stage of reproduction. Scientists have already begun to use this knowledge to allow parents the ability to select the sex of their child and screen for genetic diseases via preimplantation genetic diagnosis (PGD) with in vitro fertilization (IVF). Sex-selection has already created world-wide discussion regarding the ethics of such a situation.... [tags: Genetic Engineering ] :: 4 Works Cited 2055 words (5.9 pages) Term Papers [preview] Genetic Engineering and Experimentation - ... However, Ill be using it in the context that it is the experimentation of genetic engineering to see if its safe for the public. While you might think genetic engineering/experimentation is all fun and games while youre having your genes modified to make you smarter, or prettier, or something like that, there are consequences and dangers that can come with that modification. Then again, once perfected, genetic engineering could do a lot of good for humanity and society in general. Eliminate diseases, fix mental and psychological disabilities, maybe even (and semi-hopefully) keep people from being outright stupid.... [tags: Science, Controversy] :: 4 Works Cited 880 words (2.5 pages) Better Essays [preview] The Genetic Engineering Debate - In recent discussions of genetic engineering, a controversial issue has been whether genetic engineering is ethical or not. In The Person, the Soul, and Genetic Engineering, JC Polkinghorne discusses about the moral status of the very early embryo and therapeutic cloning. J. H. Brookes article Commentary on: The Person, the Soul, and Genetic Engineering comments and state opinions that counter Polkinghornes article. On the other hand John Harriss Goodbye Dolly? The Ethics of Human Cloning examines the possible uses and abuses of human cloning and draw out the principal ethical dimensions, both of what might be done and its meaning, and of public and official response (353).... [tags: Ethical Dilemma, Embryos With Dignity] :: 4 Works Cited 1403 words (4 pages) Powerful Essays [preview] Ethics of Genetic Modification Technology - Modern society is on the verge of a biotechnological revolution: the foods we eat no longer serve simply to feed us, but to feed entire nations, to withstand natural disasters, and to deliver preventative vaccination. Much of this technology exists due to the rapid development of genetic modification, and todays genetically modified crops are only the tip of the proverbial iceberg. Says Robert T. Fraley, chief technology officer for biotech giant Monsanto, Its like computers in the 1960s. We are just at the beginning of the explosion of technology we are going to see." Biotechnologys discontents are numerous and furious, declaring the efforts of corporations of Monsanto to be dangerous... [tags: Genetic Engineering] 776 words (2.2 pages) Better Essays [preview] Xerosotmia and genetic engineering - All around the globe, predominantly in the United States and in Europe, there are technological advances in science that affects the way people live. In recent years, genetically modified organisms (GMOs) have replaced peoples diet with genetically altered foods, which has affected human health. In a broad view, GMOs are created by splicing genes of different species that are combined through genetic engineering, consequently improving the resulting organism. Large corporations who choose to use Xerosotmia i i make larger profits with less time and effort involved (ABNE).... [tags: biology, genetically modified organisms] :: 4 Works Cited 1309 words (3.7 pages) Powerful Essays [preview] The Dangers of Genetic Engineering - Genetically manipulating genes to create certain traits in a human embryo is impossible at this point. Perhaps it will never happen. It is not inevitable in the long run, as some scientists pragmatically point out. (Embgen). It is, however, something that dominates modern day discussion concerning genetics and therefore must be addressed with care and consideration. There are many ways that gene manipulation could come about. Advances in spermatogenesis as well as the field of assisted reproductive technology, as seen in In Vitro Fertilization clinics, point toward methods that could house the systematic alteration of genetic information in reproductive cells. Transpl... [tags: Genetic Manipulation Essays] :: 5 Works Cited 1033 words (3 pages) Strong Essays [preview] Engineering the Perfect Human - For centuries, mankind has been fascinated by the idea of perfection. In recent decades, the issue has been raised regarding the perfect human and whether scientists are able to engineer and create this. Attempts have been made in the past to engineer this said perfect human, through eugenics and scientific racism, but until now, these attempts have been ineffective. Only now, with modern technology, are scientists able to make more significant progress in altering the human genome to the produce desired characteristics of perfection.... [tags: Genetic Engineering ] :: 21 Works Cited 1831 words (5.2 pages) Term Papers [preview] Can Genetic Modification Benefit Humanity? - Throughout the course of human history, new technological advancements have always created opposing views, and conflict between the different groups that hold them. Today, one of the greatest technological controversies is over the morals and practicality of genetically modifying crops and animals. Reasons for doing so vary from making them more nutritious to making plants more bountiful to allowing organisms to benefit humans in ways never before possible. Genetic engineering is a process in which genes within the DNA of one organism are removed and placed into the DNA of another, a reshuffling of genesfrom one species to another (Steinbrecher qtd.... [tags: Genetic Engineering] 1676 words (4.8 pages) Powerful Essays [preview] Genetic Engineering - In the field of animal and human genetic engineering there is much more speculation, than fact, because very little has actually been tested in the real world. Firstly, theres a big question mark over safety of genetic engineering. In addition, genetic engineering can cause greater problems than that what we have today. Moreover, we can create a injustice world between Designer vs Non-designer children. Furthermore, genetic engineering is a type of murder because of the process of genetically modifying a baby.... [tags: designer babies, perfect baby] :: 5 Works Cited 911 words (2.6 pages) Better Essays [preview] Genetic Engineering - Imagine a world where diseases can be found and prevented before they happen. This would be a future possibility if genetic engineering became more advanced. Genetic engineering is when parts of DNA are spliced into another piece of DNA which give new traits to the organism containing the DNA. Through continued research in the field of genetics, techniques such as mapping genomes and splicing DNA can be used beneficially to improve on existing organisms and their traits. To help understand genetic engineering, it is important to understand its history.... [tags: Cloning] :: 4 Works Cited 894 words (2.6 pages) Better Essays [preview] Genetic Engineering - In the 21st century, times are changing. Everyday objects are becoming perfect with alterations to their system. These alterations are not only occurring on man-made objects, but also on natural organisms, such as newborn babies. Science has come a long way to being able to have the capability to alter pre-born babies to a parents desire. There are four arguments that can be considered when discussing this topic, including nature and three others. While many scientific minds are all for creating perfection in a child, many different groups of minds are arguing this act against nature should be abolished from scientists minds.... [tags: Ethics] 888 words (2.5 pages) Better Essays [preview] Genetic Engineering - I, as a Christian, believe that the traits of a child are a blessing to a parent in one-way or another. Although I hold this true, I actually wouldnt mind being able to design my own baby. I mean, I could root out all of the bad traits, and add the ones I want. I would make my child a girl with olive skin, brown hair, bright green eyes, and to have the dancing feet of Fosse, the facial expressions of Liz Taylor, and the vocal chords of Lea Michelle. I want her to be a star of the screen or stage.... [tags: controversy, genes, physical traits, flaws] :: 3 Works Cited 890 words (2.5 pages) Better Essays [preview] Genetic Engineering - Moore's law, the statement that technologies will double every two years is a very thought-provoking inception for technologist and scientist (Moore's Law par.1). Numerous people are thrilled about this commandment while others are petrified. Why an individual might be troubled by technology one might inquire. Well there are many arguments that claim that technology is contrary to itself, nature, and humans. The unpretentious fact is technology is cohesive within the humanoid existence and will linger as time travels on.... [tags: genetically modified foods] :: 13 Works Cited 1461 words (4.2 pages) Powerful Essays [preview] Human Genetic Engineering: Dreams and Nightmares - Technological breakthroughs and advancements have occurred so rapidly since the dawn of the information age, that one often overlooks the great power humanity holds over the building blocks of life itself. While our understanding and mapping of Deoxyribonucleic acid (DNA) sequences has been slow coming since Friedrich Mieschers isolation of the double-helix shaped molecule, efforts in recent decades to map the human genome have opened many doors to the potential manipulation of lifes basic elements.... [tags: human genome, human genetics, cloning] :: 7 Works Cited 1162 words (3.3 pages) Strong Essays [preview]
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