Category Archives: Gene Medicine

Introduction

The Group is led byProf Deborah Gill andAssociate ProfSteve Hyde and forms one third of the UK Cystic Fibrosis Gene Therapy Consortium. The main aim of this Consortium of scientists and clinicians, is to make gene therapy for Cystic Fibrosis (CF) lung disease a clinical reality. Early Phase I clinical studies have already demonstrated proof of principle for CF lung gene therapy leading to correction of the CF genetic defect in the epithelium lining the nose and lung of CF patients. The clinical development of new gene therapy formulations for CF and other lung diseases is underway. The cationic lipid GL67A complexed with a novel CFTR expression plasmid has been aerosolized to the lungs of patients with Cystic Fibrosis and has been shown to be sufficiently safe for long-term evaluation. We can now deliver monthly doses of this formulation, over a 12 month period, to determine if this leads to clinical benefit. In parallel we are interested in developing viral vectors for gene delivery to the lungs. We are currently developing a new viral gene therapy vector using Lentivirus pseudotyped with envelope proteins that permit efficient entry into lung cells.

Continue reading here:
Gene Medicine Research Group - Nuffield Division of ...

Track-1 Cell Therapy:

Cell therapyas performed by alternativemedicinepractitioners is very different from the controlled research done by conventionalstem cellmedical researchers. Alternative practitioners refer to their form of cell therapy by several other different names includingxenotransplanttherapy,glandular therapy, and fresh cell therapy. Proponents ofcell therapyclaim that it has been used successfully to rebuild damaged cartilage in joints, repair spinal cord injuries,strengthen a weakenedimmune system, treat autoimmune diseases such as AIDS, and help patients withneurological disorderssuch as Alzheimers disease,Parkinson's diseaseand epilepsy.

Related Conferences:

6th International Conference onTissue Engineering & Regenerative Medicine, Baltimore, USA, Aug 20-22, 2017; 8th World Congress and Expo onCell & Stem Cell Research,Orlando, USA, March 20-22, 2017; 15thWorld Congress on Biotechnology and Biotech Industries Meet,Rome, Italy,March 20-21,2017; 2nd International Conference onGenetic Counselling and Genomic Medicine ,Beijing, China,July 10-12, 2017; International Conference onClinical and Molecular Genetics, Las Vegas, USA, April 24-26, 2017.

Track-2 Gene therapy:

Gene therapyand cell therapy are overlapping fields of biomedical research with the goals of repairing the direct cause of genetic diseases in the DNA orcellularpopulation, respectively. The development of suitablegene therapytreatments for manygenetic diseasesand some acquired diseases has encountered many challenges and uncovered new insights into gene interactions and regulation. Further development often involves uncovering basic scientific knowledge of the affected tissues, cells, and genes, as well as redesigning vectors, formulations, and regulatory cassettes for the genes.Cell therapyis expanding its repertoire of cell types for administration.Cell therapytreatment strategies include isolation and transfer of specific stem cell populations, administration of effector cells, and induction of mature cells to becomepluripotent cells, and reprogramming of mature cells.

Related Conferences:

2nd International Conference onMolecular Biology , London, UK ,June 22-24, 2017; 3rd World Bio Summit & Expo, Abu Dhabi, UAE, June 19-21, 2017; 5th International Conference onIntegrative Biology, London, UK, June 19-21, 2017; 2nd World Congress on Human Genetics, Chicago, USA, July 24-26, 2017; 9th International Conference onGenomics and Pharmacogenomics, Chicago, USA, July 13-14, 2017.

Track-3 Cell and gene therapy products:

Articles containing or consisting ofhuman cellsor tissues that are intended for implantation,transplantation, infusion, or transfer to a human recipient.Gene therapiesare novel and complex products that can offer unique challenges in product development. Hence, ongoing communication between the FDA and stakeholders is essential to meet these challenges.Gene therapy productsare being developed around the world, the FDA is engaged in a number of international harmonization activities in this area.

Examples:Musculoskeletal tissue, skin, ocular tissue, human heart valves;vascular graft, dura mater, reproductive tissue/cells, Stem/progenitor cells,somatic cells, Cells transduced withgene therapyvectors , Combination products (e.g., cells or tissue + device)

Related Conferences:

7th International Conference onPlant Genomics, Bangkok, Thailand, July 03-05, 2017; 15th Euro Biotechnology Congress, Valencia, Spain, June 05-07, 2017; International Conference onIntegrative Medicine & Nutrition, Dubai, UAE, May11-13, 2017; 14th Asia-Pacific Biotech Congress, April 10-12, 2017; Beijing, China,15th Biotechnology Congress, Baltimore, USA, June 22-23, 2017.

Track-4 Cellular therapy:

Cellular therapy, also calledlive cell therapy, cellular suspensions, glandular therapy, fresh cell therapy, sick cell therapy,embryonic cell therapy, andorgan therapy- refers to various procedures in which processed tissue from animal embryos, foetuses or organs, is injected or taken orally. Products are obtained from specific organs or tissues said to correspond with the unhealthy organs or tissues of the recipient. Proponents claim that the recipient's body automatically transports the injected cells to thetarget organs, where they supposedly strengthen them and regenerate their structure. The organs and glands used in cell treatment include brain, pituitary,thyroid, adrenals, thymus, liver,kidney, pancreas, spleen, heart,ovary, testis, and parotid. Several different types of cell or cell extract can be given simultaneously - some practitioners routinely give up to 20 or more at once.

Related Conferences:

3rd International Conference onSynthetic Biology, Munich, Germany, July 20-21, 2017; 5th International Conference and Exhibition onCell and Gene Therapy,Madrid, Spain,Mar 2-3, 2017;International Conference onCell Signalling and Cancer Therapy,Paris, France,Aug 20-22, 2017; 7th Annual Conference on Stem Cell and Regenerative Medicine, Paris, France,Aug 04-05, 2016;3rd International Conference & Exhibition onTissue Preservation and Bio banking, Baltimore, USA,June 29-30, 2017.

Track-5 Cancer gene therapy:

Cancer therapiesare drugs or other substances that block the growth and spread ofcancerby interfering with specific molecules ("molecular targets") that are involved in the growth, progression, and spread ofcancer. Many cancer therapies have been approved by the Food and Drug Administration (FDA) to treat specific types of cancer. The development of targetedtherapiesrequires the identification of good targets that is, targets that play a key role in cancer cell growth and survival. One approach to identify potential targets is to compare the amounts of individualproteinsin cancer cells with those in normal cells.Proteinsthat are present in cancer cells but not normal cells or that are more abundant incancercells would be potential targets, especially if they are known to be involved incell growthor survival.

Related Conferences:

2nd Biotechnology World Convention,London, UK,May 25-27, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; 9th International Conference onCancer Genomics, Chicago, USA, May 29-31, 2017; 6th International Conference onTissue Engineering & Regenerative Medicine, Baltimore, USA, Aug 20-22, 2017; 8th World Congress and Expo onCell & Stem Cell Research, Orlando, USA, March 20-22, 2017.

Track-6 Nano therapy:

Nano Therapymay be defined as the monitoring, repair, construction and control of human biological systems at themolecular level, using engineerednanodevicesand nanostructures. Basic nanostructured materials, engineeredenzymes, and the many products of biotechnology will be enormously useful in near-term medical applications. However, the full promise ofnanomedicineis unlikely to arrive until after the development of precisely controlled or programmable medical Nano machines andnanorobots.

Related Conferences:

15thWorld Congress on Biotechnology and Biotech Industries Meet ,Rome, Italy,March 20-21, 2017 ;2nd International Conference onGenetic Counselling and Genomic Medicine ,Beijing, China,July 10-12, 2017; International Conference onClinical and Molecular Genetics, Las Vegas, USA, April 24-26, 2017; 15th Euro Biotechnology Congress, Valencia, Spain, June 05-07, 2017; International Conference onIntegrative Medicine & Nutrition, Dubai, UAE, May11-13, 2017.

Track-7 Skin cell therapy:

Stem cellshave newly become a huge catchphrase in theskincarebiosphere. Skincare specialists are not usingembryonic stem cells; it is impossible to integrate live materials into a skincare product. Instead, scientists are creating products with specialized peptides andenzymesor plantstem cellswhich, when applied topically on the surface, help to protect the human skinstem cellsfrom damage and deterioration or stimulate the skins own stem cells. Currently, the technique is mainly used to save the lives of patients who have third degree burns over very large areas of their bodies.

Related Conferences:

5th International Conference and Exhibition onCell and Gene Therapy,Madrid,Spain,Mar 2-3, 2017;International Conference onCell Signalling and Cancer Therapy,Paris, France,Aug 20-22, 2017;2nd Biotechnology World Convention,London, UK,May 25-27, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; 9th International Conference onCancer Genomics, Chicago, USA, May 29-31, 2017.

Track-8 HIV gene therapy:

Highly activeantiretroviral therapydramatically improves survival inHIV-infected patients. However, persistence of HIV in reservoirs has necessitated lifelong treatment that can be complicated bycumulative toxicities, incomplete immune restoration, and the emergence of drug-resistant escapemutants. Cell and gene therapies offer the promise of preventing progressiveHIV infectionby interfering with HIV replication in the absence of chronicantiviral therapy.

Related Conferences:

3rd International Conference onSynthetic Biology, Munich, Germany, July 20-21, 2017; International Conference onIntegrative Medicine & Nutrition, Dubai, UAE, May11-13, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; International Conference onCell Signalling and Cancer Therapy,Paris, France,Aug 20-22, 2017;7th Annual Conference on Stem Cell and Regenerative Medicine,Paris,France,Aug 04-05, 2016.

Track-9 Diabetes for gene therapy:

Cell therapyapproaches for this disease are focused on developing the most efficient methods for the isolation ofpancreasbeta cells or appropriatestem cells, appropriate location forcell transplant, and improvement of their survival upon infusion. Alternatively, gene andcell therapyscientists are developing methods to reprogram some of the other cells of the pancreas to secreteinsulin. Currently ongoingclinical trialsusing these gene andcell therapystrategies hold promise for improved treatments of type I diabetes in the future. The firstgene therapyapproach to diabetes was put forward shortly after the cloning of theinsulingene. It was proposed that non-insulin producing cells could be made into insulin-producingcells using a suitable promoter and insulin gene construct, and that these substitute cells could restore insulin production in type 1 and some type 2 diabetics.

Related Conferences:

15thWorld Congress on Biotechnology and Biotech Industries Meet ,Rome, Italy,March 20-21, 2017;6th International Conference onTissue Engineering & Regenerative Medicine, Baltimore, USA, Aug 20-22, 2017; 8th World Congress and Expo onCell & Stem Cell Research, Orlando, USA, March 20-22, 2017; 14th Asia-Pacific Biotech Congress,Beijing, China,April 10-12, 2017;5th International Conference onIntegrative Biology, London, UK, June 19-21, 2017.

Track-10 Viral gene therapy:

Converting avirusinto a vector Theviral life cyclecan be divided into two temporally distinct phases: infection and replication. Forgene therapyto be successful, an appropriate amount of a therapeutic gene must be delivered into the target tissue without substantial toxicity. Eachviral vectorsystem is characterized by an inherent set of properties that affect its suitability for specific gene therapy applications. For some disorders, long-term expression from a relatively small proportion of cells would be sufficient (for example, genetic disorders), whereas otherpathologiesmight require high, but transient,gene expression. For example, gene therapies designed to interfere with a viral infectious process or inhibit the growth ofcancer cellsby reconstitution of inactivated tumour suppressor genes may require gene transfer into a large fraction of theabnormal cells.

Related Conferences:

3rd International Conference onSynthetic Biology, Munich, Germany, July 20-21, 2017;5th International Conference and Exhibition onCell and Gene Therapy,Madrid, Spain,Mar 2-3, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; 9th International Conference onCancer Genomics, Chicago, USA, May 29-31, 2017; 14th Asia-Pacific Biotech Congress,Beijing, China,April 10-12, 2017.

Track-11 Stem cell therapies:

Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries and other health-related conditions. Their potential is evident in the use ofblood stem cellsto treat diseases of the blood, a therapy that has saved the lives of thousands of children withleukaemia; and can be seen in the use ofstem cellsfor tissue grafts to treat diseases or injury to the bone, skin and surface of the eye. Some bone, skin andcorneal(eye) injuries and diseases can be treated bygraftingor implanting tissues, and the healing process relies on stem cells within thisimplanted tissue.

Related Conferences:

2nd World Congress on Human Genetics, Chicago, USA, July 24-26, 2017; 2nd International Conference onGenetic Counselling and Genomic Medicine ,Beijing, China,July 10-12, 2017; International Conference onClinical and Molecular Genetics, Las Vegas, USA, April 24-26, 2017; 2nd International Conference onMolecular Biology,London, UK,June 22-24, 2017; 15th Biotechnology Congress, Baltimore, USA, June 22-23, 2017.

Track-12 Stem cell preservation:

The ability to preserve the cells is critical to theirclinicalapplication. It improves patient access to therapies by increasing the genetic diversity of cells available. In addition, the ability to preserve cells improves the "manufacturability" of acell therapyproduct by permitting the cells to be stored until the patient is ready for administration of the therapy, permitting inventory control of products, and improving management of staffing atcell therapyfacilities. Finally, the ability to preservecell therapiesimproves the safety of cell therapy products by extending the shelf life of a product and permitting completion of safety and quality control testing before release of the product for use. preservation permits coordination between the manufacture of the therapy and patient care regimes.

Related Conferences:

7th Annual Conference on Stem Cell and Regenerative Medicine,Paris, France,Aug 04-05, 2016; 2nd Biotechnology World Convention,LONDON, UK,May 25-27, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; 9th International Conference onCancer Genomics, Chicago, USA, May 29-31, 2017; 3rd International Conference onSynthetic Biology, Munich, Germany, July 20-21, 2017.

Track-13 Stem cell products:

The globalstemcell,Stem cell productsmarket will grow from about $5.6 billion in 2013 to nearly $10.6 billion in 2018, registering a compound annual growth rate (CAGR) of 13.6% from 2013 through 2018.This trackdiscusses the implications ofstemcellresearchand commercial trends in the context of the current size and growth of thepharmaceutical market, both in global terms and analysed by the most important national markets.

Related Conferences:

6th International Conference onTissue Engineering & Regenerative Medicine, Baltimore, USA, Aug 20-22, 2017; 8th World Congress and Expo onCell & Stem Cell Research, Orlando, USA, March 20-22, 2017; 15thWorld Congress on Biotechnology and Biotech Industries Meet,Rome, Italy,March 20-21, 2017; 2nd International Conference onGenetic Counselling and Genomic Medicine ,Beijing, China,July 10-12, 2017; International Conference onClinical and Molecular Genetics, las vegas, USA, April 24-26, 2017.

Track-14 Genetically inherited diseases:

Agenetic diseaseis any disease that is caused by an abnormality in an individual'sgenome, the person's entiregeneticmakeup. The abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a grosschromosome abnormalityinvolving the addition or subtraction of an entirechromosomeor set of chromosomes.Most genetic diseases are the direct result of a mutation in one gene. However, one of the most difficult problems ahead is to find out how genes contribute to diseases that have a complex pattern ofinheritance, such as in the cases of diabetes,asthma,cancerandmental illness. In all these cases, no one gene has the yes/no power to say whether a person has a disease or not. It is likely that more than one mutation is required before the disease is manifest, and a number of genes may each make a subtle contribution to a person's susceptibility to a disease; genes may also affect how a person reacts toenvironmental factors.

Related Conferences:

15th Biotechnology Congress, Baltimore, USA, June 22-23, 2017; 3rd International Conference onSynthetic Biology, Munich, Germany, July 20-21, 2017; 5th International Conference and Exhibition onCell and Gene Therapy,Madrid, Spain,Mar 2-3, 2017; International Conference onCell Signalling and Cancer Therapy,paris, France,Aug 20-22, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017.

Track-15 Plant stem cells:

Plantshave emerged as powerful production platforms for the expression of fully functional recombinantmammalian proteins. These expression systems have demonstrated the ability to produce complexglycoproteinsin a cost-efficient manner at large scale. The full realization of thetherapeuticpotential of stem cells has only recently come into the forefront ofregenerative medicine. Stem cells are unprogrammed cells that can differentiate into cells with specific functions.Regenerative therapiesare used to stimulate healing and might be used in the future to treat various kinds of diseases.Regenerative medicinewill result in an extended healthy life span. A fresh apple is a symbol for beautiful skin. Hair greying for example could be shown to result from the fact that themelanocyte stem cellsin the hair follicle have died off.

Related Conferences:

9th International Conference onGenomics and Pharmacogenomics, Chicago, USA, July 13-14, 2017; 7th International Conference onPlant Genomics, Bangkok, Thailand, July 03-05, 2017; 15th Euro Biotechnology Congress, Valencia, Spain, June 05-07, 2017; 5th International Conference and Exhibition onCell and Gene Therapy,Madrid, Spain,Mar 2-3, 2017; 3rd International Conference & Exhibition onTissue Preservation and Bio banking,Baltimore, USA,June 29-30, 2017.

Track-16 Plant stem cell rejuvenation:

Asplantscannot escape from danger by running or taking flight, they need a special mechanism to withstandenvironmental stress. What empowers them to withstand harsh attacks and preserve life is the stem cell. According to Wikipedia, plantstem cellsnever undergo theagingprocess but constantly create new specialized and unspecialized cells, and they have the potential to grow into any organ, tissue, or cell in the body. The everlasting life is due to the hormones auxin andgibberellin. British scientists found that plant stem cells were much more sensitive toDNAdamage than other cells. And once they sense damage, they trigger death of these cells.

Rejuvenate with Plant Stem Cells

Detoxifyand release toxins on a cellular level. Nourishyour body with vital nutrients. Regenerateyour cells and diminish the effects of aging.

Related Conferences:

International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; 14th Asia-Pacific Biotech Congress,Beijing, China,April 10-12, 2017; 15th Biotechnology Congress, Baltimore, USA, June 22-23, 2017; 3rd International Conference onSynthetic Biology, Munich, Germany,July 20-21, 2017; 5th International Conference and Exhibition on Cell and Gene Therapy,Madrid, Spain,Mar 2-3, 2017.

Track-17 Clinical trials in cell and gene therapy:

Aclinical trialis a research study that seeks to determine if a treatment is safe and effective. Advancing new cell andgene therapies(CGTs) from the laboratory into early-phaseclinical trialshas proven to be a complex task even for experienced investigators. Due to the wide variety ofCGTproducts and their potential applications, a case-by-case assessment is warranted for the design of each clinical trial.

Objectives:Determine thepharmacokineticsof this regimen by the persistence of modified T cells in the blood of these patients, Evaluate theimmunogenicityof murine sequences in chimeric anti-CEA Ig TCR, Assess immunologic parameters which correlate with the efficacy of this regimen in these patients, Evaluate, in a preliminary manner, the efficacy of this regimen in patients with CEA bearingtumours.

Related Conferences:

2nd Biotechnology World Convention,London, UK,May 25-27, 2017; International Conference on Animal and Human Cell Culture, Jackson Ville, USA, Sep 25-27, 2017; 9th International Conference onCancer Genomics, Chicago, USA, May 29-31, 2017; 8th World Congress and Expo onCell & Stem Cell Research, Orlando, USA, March 20-22, 2017; 15thWorld Congress on Biotechnology and Biotech Industries Meet,Rome, Italy,March 20-21, 2017.

Track-18 Molecular epigenetics:

Epigeneticsis the study of heritable changes in thephenotypeof a cell or organism that are not caused by its genotype. The molecular basis of anepigeneticprofile arises from covalent modifications of protein andDNAcomponents ofchromatin. The epigenetic profile of a cell often dictates cell fate, as well as mammalian development,agingand disease. Epigenetics has evolved to become the science that explains how the differences in the patterns ofgene expressionin diverse cells or tissues are executed and inherited.

Related Confderences:

5th International Conference onIntegrative Biology, London, UK, June 19-21, 2017; 2nd World Congress on Human Genetics, Chicago, USA, July 24-26, 2017; 9th International Conference onGenomics and Pharmacogenomics, Chicago, USA, July 13-14, 2017; International Conference onIntegrative Medicine & Nutrition, Dubai, UAE, May11-13, 2017; 14th Asia-Pacific Biotech Congress,Beijing, China,April 10-12, 2017.

Track-19 Bioengineering therapeutics:

The goals ofbioengineeringstrategies for targetedcancertherapies are (1) to deliver a high dose of an anticancer drug directly to a cancer tumour, (2) to enhance drug uptake by malignant cells, and (3) to minimize drug uptake by non-malignant cells. In ESRD micro electro mechanical systems andnanotechnologyto create components such as robust silicon Nano pore filters that mimic natural kidney structure for high-efficiency toxin clearance. It also usestissue engineeringto build a miniature bioreactor in which immune-isolated human-derived renal cells perform key functions, such as reabsorption of water and salts.In drug delivery for a leading cause ofblindness, photo-etching fabrication techniques from themicrochipindustry to create thin-film and planar micro devices (dimensions in millionths of meters) with protectivemedicationreservoirs andnanopores(measured in billionths of meters) for insertion in the back of the eye to deliver sustained doses of drug across protective retinalepithelial tissuesover the course of several months.

Related Conferences:

6th International Conference onTissue Engineering & Regenerative Medicine, Baltimore, USA, Aug 20-22, 2017; 8th World Congress and Expo onCell & Stem Cell Research, Orlando, USA, March 20-22, 2017; 15thWorld Congress on Biotechnology and Biotech Industries Meet,Rome, Italy,March 20-21, 2017; 2nd International Conference onGenetic Counselling and Genomic Medicine ,Beijing, China,July 10-12, 2017; International Conference onClinical and Molecular Genetics, Las Vegas, USA, April 24-26, 2017.

Track-20 Advanced gene therapy:

Advanced therapiesare different fromconventional medicines, which are made from chemicals or proteins.Gene-therapymedicines:these contain genes that lead to atherapeuticeffect. They work by inserting 'recombinant' genes into cells, usually to treat a variety of diseases, including genetic disorders, cancer or long-term diseases.Somatic-cell therapymedicines:these contain cells or tissues that have been manipulated to change their biological characteristics.Advanced Cell &Gene Therapyprovides guidanceinprocess development, GMP/GTP manufacturing,regulatory affairs, due diligence and strategy, specializing in cell therapy,gene therapy, and tissue-engineeredregenerative medicineproducts.

Related Conferences:

9th International Conference onGenomics and Pharmacogenomics, Chicago, USA, July 13-14, 2017; 7th International Conference onPlant Genomics, Bangkong,Thailand, July 03-05, 2017; International Conference onIntegrative Medicine & Nutrition, Dubai, UAE, May11-13, 2017; 14th Asia-Pacific Biotech Congress, Beijing,China,April 10-12, 2017; 2nd World Congress on Human Genetics, Chicago, USA, July 24-26, 2017.

Link:
5th International Conference and Exhibition on Cell and ...

Access small molecules as chemical tools and for drug discovery.

Small Molecule Discovery Center

LEARN MORE >

Learn the basic principles of pharmacokinetics.

Pharmacokinetics for Pharmaceutical Scientists Course

LEARN MORE >

Explore tools to characterize and interpret genomic data.

Sequence Analysis and Consulting Service

LEARN MORE >

Sign up for cell phone tips to make your home safer from poisons.

California Poison Control System

LEARN MORE>

What meds are you taking and why?

Well make a list.

MedList Clinic

LEARN MORE >

Request state-of-the-art NMR spectroscopy for research.

Nuclear Magnetic Resonance Laboratory

LEARN MORE >

Receive an email newsletter about personalized medicine and health outcomes.

TRANSPERS Center

LEARN MORE >

Request renewable antibodies for human transcription factors and membrane proteins.

Antibiome Center

LEARN MORE >

Request mass spectrometry sample analysis.

National Bio-Organic Biomedical Mass Spectrometry Resource Center

LEARN MORE >

Be in the vanguard of medical product development and regulation.

American Course on Drug and Regulatory Sciences

LEARN MORE >

Access software tools for molecular visualization and analysis.

Resource for Biocomputing, Visualization, and Informatics

LEARN MORE >

Explore our capabilities for developing nano-scale biomedical tools and devices.

Biomedical Micro and Nanotechnology Core

LEARN MORE >

Find resources for learning how to help your patients stop using tobacco.

Rx for Change

LEARN MORE >

Go here to see the original:
School of Pharmacy | UCSF

Gene: The basic biological unit of heredity. A segment of deoxyribonucleic acid (DNA) needed to contribute to a function.

An official definition: According to the official Guidelines for Human Gene Nomenclature, a gene is defined as "a DNA segment that contributes to phenotype/function. In the absence of demonstrated function a gene may be characterized by sequence, transcription or homology."

DNA: Genes are composed of DNA, a molecule in the memorable shape of a double helix, a spiral ladder. Each rung of the spiral ladder consists of two paired chemicals called bases. There are four types of bases. They are adenine (A), thymine (T), cytosine (C), and guanine (G). As indicated, each base is symbolized by the first letter of its name: A, T, C, and G. Certain bases always pair together (AT and GC). Different sequences of base pairs form coded messages.

The gene: A gene is a sequence (a string) of bases. It is made up of combinations of A, T, C, and G. These unique combinations determine the gene's function, much as letters join together to form words. Each person has thousands of genes -- billions of base pairs of DNA or bits of information repeated in the nuclei of human cells --which determine individual characteristics (genetic traits).

The chromosome: Genes are arranged in precise arrays all along the length of 23 pairs of much larger structures: the chromosomes. One chromosome in each pair comes from the mother and the other one from the father. The chromosomes in any particular pair look like each other, except in a boy. There is one pair of chromosomes, which usually settles the sex of the individual. This pair has two X chromosomes in females and one X and one Y chromosome in males.

The X and Y chromosomes: These chromosomes -- the X and Y are always capitalized -- are the sex chromosomes. All the other chromosomes in the human chromosome complement are numbered from 1 to 22 and are called the autosomes (literally, the other chromosomes).

History of the gene: 1869-1970:

View original post here:
Gene definition - MedicineNet - Health and Medical ...

Ongoing Safety Initiatives

Pivotal clinical trials evaluate if a medicine is safe and effective enough to receive FDA approval for marketing. Even after approval, there is still a lot to learn about the medicine. For example, understanding the particular efficacy and safety profile of a medicine for pediatric uses or in the elderly.

In addition, doctors and patients may use our medicines in ways we have not already studied. So, we often conduct real world studies to assess the emerging risks and benefits of our medicine in larger or more diverse populations.

Medicines can have more than one single use. They may be used in different ways for the same disease or across diseases. A good example of this is cancer, where the biology often tells us that a medicine for treating one type of cancer could potentially work in another.

Approval initiates additional research by doctors worldwide. We may opt to partner with doctors at universities and hospitals to support these investigator-sponsored trials. And in doing so, understand the potential and limitation of a new medicine across may different diseases, dosing regimens and drug combinations.

Approval signals our ability to deliver our medicines to the patients who need it. But beyond the physical delivery, when one of our medicines is prescribed, we have a dedicated team of people who can help patients understand the range of support services we provide.

We offer coverage and co-pay support as well as patient assistance to make sure that healthcare coverage isnt a barrier to patients seeking our medicines. Whenever possible, we make sure that people can get the medicines they need, regardless of their ability to pay.

Read the rest here:
Genentech : Making Medicine

Drug-gene testing is also called pharmacogenomics, or pharmacogenetics. All terms characterize the study of how your genes affect your bodys response to medications. The word pharmacogenomics is combined from the words pharmacology (the study of the uses and effects of medications) and genomics (the study of genes and their functions).

Your body has thousands of genes that you inherited from your parents. Genes determine which characteristics you have, such as eye color and blood type. Some genes are responsible for how your body processes medications. Pharmacogenomic tests look for changes or variants in these genes that may determine whether a medication could be an effective treatment for you or whether you could have side effects to a specific medication.

Patient Information: Pharmacogenomics Finding the Right Medication for You

Pharmacogenomic testing is one tool that can help your health care provider determine the best medication for you. Your health care provider also considers other factors such as your age, lifestyle, other medications you are taking and your overall health when choosing the right treatment for you.

The purpose of pharmacogenomic testing is to find out if a medication is right for you. A small blood or saliva sample can help determine:

The laboratory looks for changes or variants in one or more genes that can affect your response to certain medications.

Each person would need to have the same specific pharmacogenomic test only once because your genetic makeup does not change over time. However, you may need other pharmacogenomics tests if you take another medication. Each medication is associated with a different pharmacogenomics test. Keep track of all your test results and share them with your health care providers.

The need for pharmacogenomics testing is determined on an individual basis. If your pharmacogenomic test results suggest you may not have a good response to a medication, your family members may have a similar response. Mayo Clinic recommends you share this information with your family members. Your health care provider can also provide recommendations for family members who may benefit from having testing.

Current limitations of pharmacogenomics testing include:

The cost of pharmacogenomics testing varies depending on which test is ordered and your health insurance coverage. To help you determine test costs and coverage:

A federal law called the Genetic Information Nondiscrimination Act (GINA) generally makes it illegal for health insurance companies to discriminate against you based on your genetic information. This federal law does not protect you against genetic discrimination by life insurance, disability insurance or long-term care insurance companies. Some states have laws in this area.

More here:
Drug-Gene Testing - Mayo Clinic Research

Bookshelf

A collection of biomedical books that can be searched directly or from linked data in other NCBI databases. The collection includes biomedical textbooks, other scientific titles, genetic resources such as GeneReviews, and NCBI help manuals.

A resource to provide a public, tracked record of reported relationships between human variation and observed health status with supporting evidence. Related information intheNIH Genetic Testing Registry (GTR),MedGen,Gene,OMIM,PubMedand other sources is accessible through hyperlinks on the records.

A registry and results database of publicly- and privately-supported clinical studies of human participants conducted around the world.

An archive and distribution center for the description and results of studies which investigate the interaction of genotype and phenotype. These studies include genome-wide association (GWAS), medical resequencing, molecular diagnostic assays, as well as association between genotype and non-clinical traits.

An open, publicly accessible platform where the HLA community can submit, edit, view, and exchange data related to the human major histocompatibility complex. It consists of an interactive Alignment Viewer for HLA and related genes, an MHC microsatellite database, a sequence interpretation site for Sequencing Based Typing (SBT), and a Primer/Probe database.

A searchable database of genes, focusing on genomes that have been completely sequenced and that have an active research community to contribute gene-specific data. Information includes nomenclature, chromosomal localization, gene products and their attributes (e.g., protein interactions), associated markers, phenotypes, interactions, and links to citations, sequences, variation details, maps, expression reports, homologs, protein domain content, and external databases.

A collection of expert-authored, peer-reviewed disease descriptions on the NCBI Bookshelf that apply genetic testing to the diagnosis, management, and genetic counseling of patients and families with specific inherited conditions.

Summaries of information for selected genetic disorders with discussions of the underlying mutation(s) and clinical features, as well as links to related databases and organizations.

A voluntary registry of genetic tests and laboratories, with detailed information about the tests such as what is measured and analytic and clinical validity. GTR also is a nexus for information about genetic conditions and provides context-specific links to a variety of resources, including practice guidelines, published literature, and genetic data/information. The initial scope of GTR includes single gene tests for Mendelian disorders, as well as arrays, panels and pharmacogenetic tests.

A database of known interactions of HIV-1 proteins with proteins from human hosts. It provides annotated bibliographies of published reports of protein interactions, with links to the corresponding PubMed records and sequence data.

A compilation of data from the NIAID Influenza Genome Sequencing Project and GenBank. It provides tools for flu sequence analysis, annotation and submission to GenBank. This resource also has links to other flu sequence resources, and publications and general information about flu viruses.

A portal to information about medical genetics. MedGen includes term lists from multiple sources and organizes them into concept groupings and hierarchies. Links are also provided to information related to those concepts in the NIH Genetic Testing Registry (GTR), ClinVar,Gene, OMIM, PubMed, and other sources.

A project involving the collection and analysis of bacterial pathogen genomic sequences originating from food, environmental and patient isolates. Currently, an automated pipeline clusters and identifies sequences supplied primarily by public health laboratories to assist in the investigation of foodborne disease outbreaks and discover potential sources of food contamination.

A database of human genes and genetic disorders. NCBI maintains current content and continues to support its searching and integration with other NCBI databases. However, OMIM now has a new home at omim.org, and users are directed to this site for full record displays.

A database of citations and abstracts for biomedical literature from MEDLINE and additional life science journals. Links are provided when full text versions of the articles are available via PubMed Central (described below) or other websites.

A digital archive of full-text biomedical and life sciences journal literature, including clinical medicine and public health.

A collection of clinical effectiveness reviews and other resources to help consumers and clinicians use and understand clinical research results. These are drawn from the NCBI Bookshelf and PubMed, including published systematic reviews from organizations such as the Agency for Health Care Research and Quality, The Cochrane Collaboration, and others (see complete listing). Links to full text articles are provided when available.

A collection of resources specifically designed to support the research of retroviruses, including a genotyping tool that uses the BLAST algorithm to identify the genotype of a query sequence; an alignment tool for global alignment of multiple sequences; an HIV-1 automatic sequence annotation tool; and annotated maps of numerous retroviruses viewable in GenBank, FASTA, and graphic formats, with links to associated sequence records.

A summary of data for the SARS coronavirus (CoV), including links to the most recent sequence data and publications, links to other SARS related resources, and a pre-computed alignment of genome sequences from various isolates.

An extension of the Influenza Virus Resource to other organisms, providing an interface to download sequence sets of selected viruses, analysis tools, including virus-specific BLAST pages, and genome annotation pipelines.

View original post here:
Genetics & Medicine - Site Guide - NCBI

My Philosophy and Approach to Wellness... As an internist in the Rochester, New York area with 35 years of knowledge and experience, I strive to meet the personal needs of each of my patients through a preventive healthcare model, sometimes compared to concierge care.

Located in Pittsford, New York, my primary care practice serves patients in Monroe County, as well as locations between Buffalo and Syracuse and south of Rochester. I am affiliated with Rochester General Hospital. If hospitalized, I will visit you and coordinate your care with specialists at Strong Memorial, Highland and Unity hospitals. I regularly collaborate with the leading specialists in cardiology, neurology, psychiatry and geriatrics.

As a private internal medicine physician, my patients receive same-day or next-day visits in an unhurried, relaxed office where I can listen, diagnose and help you achieve your optimal health through wellness and prevention.I am never too busy to see you, and that includes house calls.I am just a phone call away, including evenings and weekends. I believe a very strong doctor-patient relationship is essential in achieving the best plan for healthy living and prevention of illness.

I believe that diet and exercise are essential components in achieving good health and I practice what I preach. I enjoy organic gardening and exercise regularly by swimming laps.My staff is very welcoming, efficient and will personally answer your calls and questions.I invite you to call my office and allow my staff to arrange a complimentary face-to-face office visit. Let me understand your health goals and show you how my proactive and personalized approach to healthcare will improve your life.

Click to Enlarge

Dr. Zito is one of those rare doctors that actually takes the time to LISTEN to his patients. He gets to the root of what works an...

Feel very comfortable with Dr. Zito and his expanations of my problems

Dr Zito has been our family primary care doctor ever since we moved to USA from UK, He and his staff has been are extremely caring...

I was in the hospital and the on call cardiologist said that I was fine to be discharged even after my complaining of severe pain ...

See original here:
Gene M. Zito, MD - Internal Medicine Doctor in Pittsford ...

Assistant Professor of Clinical Pathology and Dermatology Director of Dermatopathology

Dr. Kim is an assistant professor of dermatology and pathology at USC where he serves as the director of dermatopathology. He joined the Keck School of Medicine in July 2008.

Dr. Kim has lived and trained in many parts of the United States. Most recently, he completed a dermatopathology fellowship at Northwestern University in Chicago. Prior to that, he joined the faculty at Indiana University Department of Dermatology in Indianapolis.

Dr. Kim completed his dermatology residency at New York University in Manhattan where he also served as chief resident. He earned his undergraduate and medical degrees from Duke University and Indiana University, respectively.

Dr. Kim has earned numerous academic distinctions during his career. In addition to these distinctions, Dr. Kim has also won awards for community service leadership. Dr. Kim cares for patients with all types of dermatologic conditions. He is also available for dermatopathology consultations.

More here:
Keck Medicine of USC - Gene H. Kim

Introduction

The Academies have provided leadership in the past on controversial new areas of genetic research, such as recombinant DNA technology, human embryonic stem cell research, human cloning, and gain-of-function research. In keeping with these past efforts, the National Academy of Sciences and the National Academy of Medicine have launched a new initiative to inform decision making related to recent advances in human gene-editing research. [Learn about related Academies studies and reports on genetic research]

The initiative includesan international summit to convene global experts to discuss the scientific, ethical, and governance issues associated with human gene-editing research, as well as a comprehensive studyby a multidisciplinary, international committee that will examine the scientific underpinnings and clinical, ethical, legal, and social implications of human gene editing. The committee will issue a report in 2016 with findings and recommendations for the responsible use of human gene-editing research.

Latest News

Upcoming Public Meeting in Paris The consensus committee will host a public meeting in Paris on April 29 focusing on the principles underlying human gene editing governance and policy.This event will be held one day after a workshop on the current scientific activities and regulatory landscape for human gene editing in the European Union, organized by the Federation of European Academies of Medicine. Both meetings will be held at the French National Academy of Medicine.'Subscribe for Updates' to receive updates about the meeting agendas, speakers, and webcast availability.

Slides and Videos from the February MeetingOn Feb. 11, the NAS/NAM Human Gene Editing consensus committee heard input from select stakeholder groups, includingpublic engagement experts, affected communities, industry, regulatory bodies, and members of the public who came to share their perspectives. Presentation slides and recorded videos of the talks and discussions are now available online.

Summary of International Summit Now Available A Meeting in Brief is now available that summarizes the December International Summit on Human Gene editing.

More News

About This Initiative

Powerful new gene-editing technologies, such as CRISPR-Cas9, hold great promise for advancing science and treating disease, but they also raise concerns and present complex challenges, particularly because of their potential to be used to make genetic changes that could be passed on to future generations, thereby modifying the human germline.

The National Academy of Sciences and the National Academy of Medicine's human gene-editing initiative will provide researchers, clinicians, policymakers, and societies around the world with a comprehensive understanding of human gene editing to help inform decision making about this research and its application.

Subscribe to our mailing list for updates by clicking on the button below.Questions about the initiative should be directed togeneediting@nas.edu.

See the rest here:
Home | Human Gene-Editing Initiative - National-Academies.org