Category Archives: Eczema

Essential oils are commonly used in the treatment of acne, rosacea, eczema, and other skin conditions. A good example is rosemary essential oil, which may help destroy Propionibacterium acnes, the bacterium responsible for acne breakouts, reports a 2007 study published in Planta Medica. You may also try tea tree oil for its antibacterial and anti-inflammatory effects. This natural remedy is rich in terpenes, limonene, and other phytochemicals that may help kill common bacterial strains like P. acnes, S. aureus, Lactobacillus, and E. coli, according to 2015 research featured in the journal Clinical Microbiology Reviews.

Another option is lavender essential oil, which can accelerate healing and prevent acne scars. David Karlak and Susan Griffin-Black, two experts interviewed by Byrdie, also recommend cypress, rosehip seed, or jojoba oil. For example, rose oil contains farnesol, a compound that soothes dry skin and reduces excess sebum, notes Griffin-Black.

Remember to dilute your favorite essential oils with a carrier oil before applying them to the skin. These products are very concentrated and may cause irritation if used undiluted. As a general rule, add one drop of essential oil for every three drops of coconut, avocado, or olive oil, suggests doTerra. Lavender essential oil can be used as is, but it's best to dilute it if you have sensitive skin.

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Holistic Acne Treatments That Are Better Than What You've Been Doing - The List

A call centre operator plagued by such virulent eczema she was left balding, bedbound and slept in a balaclava to stop her oozing face from sticking to the pillow says a life-changing 9 cream cleared her skin overnight.

While Kimberley Reardon, 30, suffered with mild baby eczema until she was three-years-old, it did not flare-up again until her teens and it was only in her 20s that her catastrophic problems began and she was covered from head-to-toe in red raw patches of the dry, flaking skin condition.

For the next decade, her eczema frequently developed into painful, weeping sores and saw Kimberley trying numerous steroid creams.

However, the treatements would work only briefly, before the angry conditionreturned with such vigour she would be unable to move without her skin weeping or peeling.

After several hospitalisations, infections and periods of being bedbound, by March 2022 Kimberley, who lives with her boyfriend of 12 years, healthcare assistant, Scott Hannah, 31, had lost hope only for her mum to stumble upon 8.99 Balmonds Skin Salvation cream that practically cleared her skin overnight.

Kimberley, of Hamilton, South Lanarkshire, Scotland, said: I was exhausted and hopeless. It felt like it was never ending.

I had spent nearly 10 years in chronic pain and itwas an achievement for me to just get myself washed and dressed in the morning.

I have tried so many creams that dont work, so when my mum suggested I tried this one, I was very sceptical about it working.

But, when I woke up the next day, my face was almost clear it was unbelievable.

Kimberley Reardon, 30, in May 2018, before her skin spiraled out of control (Collect/PA Real Life)

Despite suffering with mild baby eczema, her skin complaints only really started in her teens.

She said: My parents would usually use a cream on me as a baby which would work, but then the eczema appeared again when I was going through exams at 15.

It started on my back and spread to the creases in my elbows, with patches of redness.

It bothered me, but it hadnt spread to my face at that point, so I could just hide it.

Kimberleys eczema covering her face and neck in March 2020 (Collect/PA Real Life)

To ease the eczema, Kimberley was prescribed a steroid cream which was steadily increased in dosage to match her increasing flare ups. But hitting 20, the steroid creams seemed to stop working and during the next three years her condition intensified and spread to her face.

Kimberley Reardon, 30, and Scott Hannah, 31, have been together for 12 years (Collect/PA Real Life)

She said: I was studying for my social sciences degree at university, working part-time in a call centre and caring for my grandad because he was poorly and he had pneumonia.

Stress was definitely a trigger for my eczema, which went from some scaly patches to covering my whole body in red, inflamed dry skin that was just falling off my face.

Kimberleys arm was red raw in December 2020 (Collect/PA Real Life)

She added: My arms looked like red sleeves, while my legs were also covered and my neck was incredibly sore.

It was unmanageable. I was trying to use creams, emollients and moisturisers and wrapping myself in bandages, to try and help them to be absorbed into my skin.

Diagnosed with severe and widespread erythema at 23 a rash caused by injured or inflamed blood capillaries, usually in response to a drug, disease or infection Kimberleys skin became worse and worse.

Kimberley Reardon, 30, with makeup on for the first time in years (Collect/PA Real Life)

I wasnt functioning at all, I was exhausted, she said.

I felt ruined, like my body was fighting against me constantly.

It felt like I had severe sunburn over my whole body as if it was burning me from the inside out.

Kimberleys hand raw and peeling earlier this year, in April 2022 (Collect/PA Real Life)

After years fighting the eczema without success, Kimberley felt depressed, although she still tried to go out and have a normal life.

She said: I remember putting foundation on the top of my hands to try and cover the red patches,

One time a woman saw my hand when I pushed the lift button at work and she said, Oh! Have you been burnt? I felt so embarrassed.

I started wearing foundation to try and cover the patches, as well as long sleeves and big jumpers, even in the summer to try and hide my skin.

Kimberleys skin flaking and peeling in September 2020 (Collect/PA Real Life)

I felt so out of control of my skin that I started to micromanage everything else that I could to compensate.

Even though it hurt to move, I was hoovering six times a day to clear my skin up.

I was in so much pain, but I became obsessive about things.

I couldnt leave dishes out and I became totally over the top with cleaning and constantly checking my money, even though I knew I could pay my bills.

Kimberley Reardon, 30, with her boyfriend, Scott Hannah, 31(Collect/PA Real Life)

In 2018, Kimberleys skin condition became so bad she was hospitalised.

She said: My mum took one look at me and was horrified.

Ninety five per cent of my body was covered in red, swollen and burning skin.

I was losing too much fluid through my skin, where I was oozing out.

Kimberley Reardon on March 13, 2022 (Collect/PA Real Life)

She added: And the doctors said I was critically ill. My skin was so weak and I wasnt able to regulate my temperature.

After two weeks on an IV drip in hospital, Kimberley was placed on immunosuppressants and five months of oral steroids, to try and tame her excruciating eczema.

And when 2020 hit, she found herself completely bedbound.

Kimberley Reardon, 30, in March 2018, covering her red hands in foundation (Collect/PA Real Life)

She said: From January to March, my skin was the worst it had even been.

Doctors doubled my doses of immunosuppressants but nothing worked.

I had to have spare sheets to change and lie on every few hours. I was ruining the bed sheets where my skin was so flaky and oozy.

I was spending hours lying in really hot baths, because they seemed to be the only thing that relieved my skin, although it would be worse when I got out.

Kimberley said it was a blessing working from home in lockdown because of the pain and fear of judgement (Collect/PA Real Life)

She added: I was crying constantly and I didnt look like me at all.

I would think, Am I ever going to get better, is this it?'

When the March 2020 lockdown came in, it was a saving grace for Kimberley, as she was able to better manage her pain while she was working from home.

Prescribed new immunosuppressants, her skin briefly cleared but even then, she was plagued with a litany of other side effects.

Kimberley Reardon, 30, struggled immensely with her skin in 2020 (Collect/PA Real Life)

My skin was amazing but I was having other problems, she said.I was vomiting all the time, sleeping all the time and I couldnt keep food down.

Then, in July 2020, her skin flared up again so severely that she was hospitalised once more and signed off work for five months.

She said: I was bitten by an insect, which caused an abscess and cellulitis, a bacterial skin infection, because I had no immunity.

Kimberley trying to get through the pain in August 2020(Collect/PA Real Life)

Kimberley added: I was in hospital for two weeks on a drip again and antibiotics, followed by another three weeks of antibiotics at home.

I was bedbound, I barely got up and my poor boyfriend was carrying me to the toilet and running the bath for me.

I barely got changed, as it would take me hours to get dressed.

I lost my hair from the stress on my head, eyebrows and even my eyelashes.

And I didnt sleep for months because of the pain.

I was bedbound, I barely got up and my poor boyfriend was carrying me to the toilet and running the bath for me

Kimberley tried to go cold turkey without any medication to see if her body could heal itself, but nothing seemed to improve.

My face was covered, my body was covered, she said.

My boyfriend had to care for me, I couldnt do anything.

I spent my days in pain, just watching TV, or I sat in the bath for hours for some relief.

The worst thing for me was feeling like such a burden.

Kimberley Reardon, 30, with her clear skin in May 2022 (Collect/PA Real Life)

In a bid to help moisturising remedies to be absorbed and to stop her skin from weeping on everything, Kimberley would wrap herself up like a parcel.

She said: I was living in my eczema jammies, with long sleeves and long legs.

I would use bandages for my neck and my mum even got me a balaclava to sleep in at night, to stop my face sticking onto my pillows where it wept so much.

Kimberley felt very grateful for the support from her boyfriend, family and friends, but still felt mortified by her situation.

I was so embarrassed, I was completely mortified to be seen, she said.

If I went for a walk, I would just stare at the ground and never look anyone in the eye.

My boyfriend would always be so lovely. Whenever I started to feel bad, he would always bring me straight back up again.

In another attempt to clear her skin, in December 2020 Kimberley was prescribed a biologic an injection which targets the gene that causes inflammation which for three months cleared her skin.

Kimberley Reardon, 30, in September 2020 compared to now, with clear skin (Collect/PA Real Life)

I felt amazing, she said.

I was fatigued and achy from the side effects, but I felt so happy that something was working.

I had my first date night since 2019 at Frankie and Bennys with my boyfriend.

But, just as things were looking up, she developed a fungal infection across her arms and chest in February 2021.

It was so itchy. I was scratching so much I was ripping my skin off

She said: It was so itchy. I was scratching so much I was ripping my skin off.

So desperate to find something that worked, Kimberley even tried cryotherapy the use of extreme cold to freeze abnormal tissue for six weeks in July 2021.

She said: Once a week, I would stand in this freezing chamber, with temperatures at minus 110 to reduce inflammation.

It didnt work, it made me go purple, but I tried it as I was so desperate to do something and so scared of being bedbound again.

Just when she believed there was nothing else left to try, Kimberleys mum, Janey Reardon, 56, a retired receptionist, discovered the 9 cream in March this year.

Picking up a 30ml bottle for 8.99, she handed it to her daughter who cautiously applied some to a small patch on her finger.

She said: There had been no reaction in an hour, so I thought hopefully it would be okay.

I slathered it on and overnight and when I got up, my face was almost clear.

I couldnt believe it.

Using the cream every day, within one week, Kimberley was astounded to see that her skin was still miraculously clear.

And for the first time since 2019, she felt confident enough about her appearance to go to a coffee shop alone.

She said: I had a green tea in the coffee shop and for the first time in as long as I could remember, I wasnt worrying about people looking at my face.I had three date nights that week, one at the cinema and two foodie dates.

Even just going for a walk again was amazing.

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Woman left balding and bedbound by chronic eczema clears the condition with a 9 face cream - The Independent

BARCELONA, Spain, June 7, 2022 /PRNewswire/ -- Almirall S.A. (BME: ALM) today announced topline results from one-year analyses of the efficacy and safety of lebrikizumab, an investigational IL-13 inhibitor for the treatment of patients with moderate-to-severe atopic dermatitis (AD). The new findings from the Phase 3 clinical trials (ADvocate 1 and 2) showed eight out of ten patients who achieved clinical response (EASI-75*) with lebrikizumab monotherapy at 16 weeks maintained skin clearance at one year of treatment with the once every two weeks or four weeks regimen. Additionally, patients treated with lebrikizumab maintained itch relief across the two trials over the one-year period. These results build upon positive datafrom the 16-week, double-blind, placebo-controlled part of the ADvocate program.

"We are pleased to witness how lebrikizumab has proven over a year its potential to be a leading option for the treatment of atopic dermatitis. ADvocate 1 and 2 results add to the exciting, growing body of evidence from our Phase 3 clinical trial program and demonstrate that this medicine may provide much-needed relief for those seeking new treatment options. We look forward to continuing our collaboration with Lilly and advancing in our clinical program, aiming to obtain approval in the European Union," stated Karl Ziegelbauer, Ph.D., Almirall's Chief Scientific Officer.

AD, or atopic eczema, is a chronic, relapsing, heterogenous skin disease characterized by intense itching, dry skin and inflammation that can be present on any part of the body.1-2 Lebrikizumab is a novel, monoclonal antibody (mAb) that binds to the interleukin-13 (IL-13) protein with high affinity to specifically prevent the formation of IL-13R1/IL-4R(Type 2 receptor) which blocks downstream signaling through the IL-13 pathway.3-7 IL-13 plays the central role in AD, promoting Type 2 inflammation that drives skin barrier dysfunction, itch, skin thickening and infection.8-10

In ADvocate 1, 79% of patients who received lebrikizumab every four weeks and 79% of patients who received lebrikizumab every two weeks maintained 75% or greater skin improvement (EASI-75) at one year of treatment. Additionally, 85% of patients who received lebrikizumab every four weeks and 77% of patients who received lebrikizumab every two weeks maintained EASI-75 response in ADvocate 2 at one year of treatment.

The frequency of adverse events and the overall safety profile among these patients treated with lebrikizumab were consistent with the induction phase of the trials as well as previous lebrikizumab studies in AD. No new safety signals were observed in this patient population.

"In these studies, patients treated with lebrikizumab maintained skin clearance and lasting relief from intense itch at one year. We look forward to providing an important new medicine and helping patients find the relief they so desperately seek from the varied and debilitating symptoms of this disease, contingent upon FDA approval," said Lotus Mallbris, M.D., Ph.D., vice president of global immunology development and medical affairs at Eli Lilly and Company.

With these data, Almirall plans to submit a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) for lebrikizumab in AD in the second half of 2022. Lilly also plans to submit an application to the U.S. Food and Drug Administration (FDA) this year, followed by submissions to other regulatory agencies around the world.

These studies are part of the comprehensive clinical development program for lebrikizumab in AD evaluating more than 2,000 patients. Full one-year results from the Phase 3 monotherapy studies will be disclosed at upcoming congresses and in publications in 2022. Additional Phase 3 clinical trials are enrolling for lebrikizumab in AD.

Almirall has licensed the rights to develop and commercialize lebrikizumab for the treatment of dermatology indications, including AD, in Europe. Lilly has exclusive rights for development and commercialization of lebrikizumab in the United States and the rest of the world outside Europe.

*EASI=Eczema Area and Severity Index, EASI-75=75 percent reduction in EASI from baseline to Week 16

About ADvocate 1 and ADvocate 2 and the Phase 3 Program

ADvocate 1andADvocate 2are 52-week randomized, double-blind, placebo-controlled, parallel-group, global, Phase 3 studies designed to evaluate lebrikizumab as monotherapy in adult and adolescent patients (aged 12 to less than 18 years of age and weighing at least 40 kg) with moderate-to-severe AD.During the 16-week treatment period, patients received lebrikizumab 500-mg initially and at two weeks, followed by lebrikizumab 250-mg or placebo every two weeks. In the maintenance period, patients with moderate-to-severe AD who achieved a clinical response after 16 weeks of lebrikizumab treatment were re-randomized to receive lebrikizumab every two weeks or every four weeks or placebo for an additional 36 weeks.Patients who required rescue treatment during the induction period or who did not achieve clinical response (lebrikizumab non-responders) at 16 weeks received lebrikizumab every two weeks for an additional 36 weeks.The primary endpoints were measured by an Investigator Global Assessment (IGA) score of clear (0) or almost clear (1) skin with a reduction of at least two points from baseline and at least 75 percent change in baseline in the Eczema Area and Severity Index (EASI-75) score at 16 weeks. EASI measures extent and severity of the disease. Key secondary endpoints were measured by IGA, EASI, the Pruritus Numeric Rating Scale, Sleep-Loss due to Pruritus and the Dermatology Life Quality Index.

The U.S. Food and Drug Administration (FDA) granted lebrikizumab Fast Track designation in AD in December 2019. The lebrikizumab Phase 3 program consists of five key global studies including two monotherapy studies, a combination study (ADhere), as well as long-term extension (ADjoin) and adolescent open label (ADore) studies.

About Lebrikizumab

Lebrikizumab is a novel, investigational, monoclonal antibody designed to bind IL-13 with high affinity to specifically prevent the formation of the IL-13R1/IL-4R heterodimer complex and subsequent signaling, thereby inhibiting the biological effects of IL-13 in a targeted and efficient fashion. IL-13 is the central pathogenic mediator of AD, promoting Type 2 inflammation that drives skin barrier dysfunction, itch, skin thickening and infection.6-8

About Almirall

Almirall is a global biopharmaceutical company focused on skin health. We collaborate with scientists and healthcare professionals to address patient's needs through science to improve their lives. Our Noble Purpose is at the core of our work: "Transform the patients' world by helping them realize their hopes and dreams for a healthy life". We invest in differentiated and ground-breaking medical dermatology products to bring our innovative solutions to patients in need.

The company, founded in 1943 and headquartered in Barcelona, is publicly traded on the Spanish Stock Exchange and is a member of the IBEX35 (ticker: ALM). Throughout its 79-year history, Almirall has retained a strong focus on the needs of patients. Currently, Almirall has a direct presence in 21 countries and strategic agreements in over 70, with about 1,800 employees. Total revenues in 2021 were 836.5 million euros.

For more information, please visit almirall.com

Legal warning

This document includes only summary information and is not intended to be exhaustive. The facts, figures and opinions contained in this document, in addition to the historical ones, are "forward-looking statements". These statements are based on the information currently available and the best estimates and assumptions that the Company considers reasonable. These statements involve risks and uncertainties beyond the control of the Company. Therefore, actual results may differ materially from those declared by such forward-looking statements. The Company expressly waives any obligation to revise or update any forward-looking statements, goals or estimates contained in this document to reflect any changes in the assumptions, events or circumstances on which such forward-looking statements are based, unless required by the applicable law.

1Weidinger S, Novak N. Lancet. 2016;387:1109-1122.2Langan SM, et al. Arch Dermatol. 2008;142:1109.3Moyle M, et al. Exp Dermatol. 2019;28(7):756-768.4 Ultsch M, et al. J Mol Biol. 2013;425(8):1330-1339.5Zhu R, et al. Pulm Pharmacol Ther. 2017;46:88-98.6Simpson EL, et al. J Am Acad Dermatol. 2018;78(5):863-871.e11.7Okragly A, et al. Comparison of the Affinity and in vitro Activity of Lebrikizumab, Tralokinumab, and Cendakimab. Presented at the Inflammatory Skin Disease Summit, New York, November 3-6, 2021.8Tsoi L, et al. Journal of Investigative Dermatology. 2019;139(7):1480-1489.9Ratnarajah K, et al. Journal of Cutaneous Medicine and Surgery. 2021;25(3):315-328.10Bieber T. Allergy. 2020;75(1):54-62.

Logo - https://mma.prnewswire.com/media/1217694/Almirall_Logo.jpg

SOURCE Almirall, S.A.

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Almirall: Eight out of Ten Patients Maintained Skin Clearance at One Year in Lebrikizumab Atopic Dermatitis Monotherapy Trials - PR Newswire UK

Tile Warehouse has surveyed the UK public to determine who abides by the five-second rule, and how its perceived differently across the country. This so-called rule says food is OK to eat if you pick it up in five seconds or less.

Results have revealed that the threat of contamination isnt stopping Brits from eating fallen food, with almost six in 10 (59%) agreeing that they would still eat food that had touched the floor. Of those who agreed, one in six (16%) preferred to only leave food for four to five seconds, following the favoured rule's steps.

Just over 1% claimed that they would eat food left on the floor for up to one minute. Even more shockingly, one in 20 people (5%) claimed that they would eat the food no matter how long it had been left on the floor.

The study found that women (56%) were less likely to eat food off the floor than men (61%). It seems that generational divides also extend to the five-second rule, with millennials (aged 24-42) the most likely to leave food on the floor the longest.

Members of this generation gave seven seconds as the average amount of time they would comfortably leave food on the floor before eating it. A closer look at the regions found that those in Scotland were likely to leave food on the floor for the longest amount of time with an average of 10 seconds.

In second place was Greater London, with residents admitting they would leave their food on the floor for a maximum of six seconds at a time. The research was conducted by Censuswide among 2,000 general consumers aged 18 and over in May 2022.

For more stories from where you live, visit InYourArea.

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Poll: Six in 10 people would eat food that has fallen on the floor - Coventry Live

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The itch that rashes: Treating and understanding eczema - El Paso Inc.

Jessica Simpson is famous for speaking her truth and that includes sharing details about her life with eczema.

I experienced it in junior high and high school, and after cheerleading, I would just put on my letter[man] jacket or a sweatshirt because people would hug me and be like, What is that on your arm? recalled the singer turned fashion mogul in an interview with People.

Im open about my insecurities and my flaws, and if I can help inspire anybody to feel better about themselves, thats why Im here, she added.

Simpsons willingness to discuss her challenges with atopic dermatitis (the most common form of eczema) has helped shine a light on a condition that many people would prefer to hide.

In fact, the emotional impact of the condition, along with the physical discomfort, may increase a persons risk of new depression and anxiety, according to a study published in 2020 in the Journal of Allergy and Clinical Immunology.

While eczema is common in children and young adults, it can appear at any age. The condition seems to affect the same number of female and male children, but studies have shown it is more common in adult women than men.

Simpson isnt the only superstar who has been candid about her private struggles with this skin condition that 1 in 10 Americans develop at some point during their lifetime. Here are some household names with atopic dermatitis.

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Celebrities With Eczema Speak Out - Everyday Health

Study findings provide evidence that preventative antibiotics improve health outcomes for babies and mothers, investigator say.

New research results showed that antibiotics given to women before a caesarean birth have no effect on the risk of early childhood conditions, such as asthma or eczema, according to investigators at the Universities of Birmingham and Warwick.

The results further support recommendations made by the National Institute for Health and Care Excellence (NIHCE), which claims that preventative antibiotics should be offered to mothers before undergoing C-sections. Updated in 2011, the guidance was created to minimize the risk of infection and notes that the mother will get the most benefit from antibiotics given shortly before C-sections compared with after the babys cord is clamped.

Although caesarean birth is common, so no known health harms are noted, if antibiotics are given before clamping the babys cord, it can cross the placenta and affect microbes in the babys gut. The microbes include bacteria that are expected to benefit the development and health of the immune system.

The research team compared the risk of allergy-related conditions in the first 5 years after birth in children born by both before and after the change in NIHCE guidelines, using records from several children born between 2006 and 2018 in United Kingdom-wide health care databases.

The results suggest that the policy of preventative antibiotics before a C-section has no effect on the risk of these early childhood conditions developing.

Maternal infections, such as wound infection, can be a risk in the period immediately after birth. Preventative antibiotics are of most benefit to the mother if given before the caesarean section is carried out, lead study author Dana Sumilo, MD, said in a statement. There is no known harm from these antibiotics to the babies born by caesarean birth, and our findings also suggest no effect on the risk of health conditions, such as asthma and eczema in early childhood.

Further, Andrew Shennan, clinical director at NIHR Clinical Research Network South London, added that these new findings are promising and provide more evidence that preventative antibiotics improve health outcomes for mothers and babies.

This arms clinicians with key evidence enabling them to ensure antibiotics are used wisely and at the optimum point for the most effective treatments, he said in the statement.

Reference

Antibiotics given shortly before caesarean birth not linked to asthma and eczema in young children. EurekAlert! News release. May 18, 2022. Accessed May 23, 2022. https://www.eurekalert.org/news-releases/952933

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Antibiotics Given Before C-sections Are Not Linked to Asthma, Eczema in Young Children - Pharmacy Times

THURSDAY, June 2, 2022 (HealthDay News) -- There are no differences in effectiveness between the four main types of moisturizers for childhood eczema, according to a study published online May 23 in The Lancet Child & Adolescent Health.

Matthew J. Ridd, Ph.D., from the University of Bristol in the United Kingdom, and colleagues compared the clinical effectiveness and safety of the four main emollient types. Children (aged 6 months to 12 years) with eczema were randomly assigned to lotions (137 children), creams (140 children), gels (135 children), and ointments (138 children).

The researchers observed no difference in eczema severity between emollient types over 16 weeks. Results remained unchanged even with multiple imputation, sensitivity, and subgroup analyses. There were also no differences seen in total number of adverse events between the treatment groups (36, 39, 40, and 35 percent for lotions, creams, gels, and ointments, respectively). However, stinging was less common with ointments (9 percent) compared with lotions (20 percent), creams (17 percent), and gels (19 percent).

"A study of this type has been long overdue. It has not been in the interest of the manufacturers to directly compare types of moisturizer in the way we have done in this trial," Ridd said in a statement. "Our findings challenge conventions about how often moisturizers need to be applied, which types are less likely to cause problems and which patients should be recommended certain types."

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Lotion, Cream, Gel, and Ointment Similarly Effective for Childhood Eczema - HealthDay News

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Eczema Skin-Care Products Market, By Type

Atopic Dermatitis Contact eczema Seborrheic eczema Nummular eczema Neurodermatitis Stasis dermatitis Dyshidrotic eczema

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Lotions and Ointments Cleansers Detergents Humidifiers

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Eczema Skin-Care Products Market Size, Scope and Forecast | Alliance Pharma Plc., Bausch Health Companies Inc., Bayer AG., AbbVie Inc., Eli Lilly and...

Ceramides are lipid molecules that play an important role in the structure and barrier function of the skin, such as preventing moisture loss and protecting against environmental damage. Although the body produces ceramides, levels in the skin decline with age.

When ceramide levels decline, it can lead to drier, more sensitive skin or other issues. However, people can take supplements or use skin care products that contain ceramides to replenish their levels. Some research suggests that these may help improve skin health.

Keep reading to learn more about ceramides, their benefits, and potential drawbacks for the skin.

Ceramides a type of lipid made of sphingosine and a fatty acid constitute about 50% of the intercellular stratum corneum lipids. These are the lipids between the cells of the top layer of the epidermis.

Ceramides play a role in brain and nervous system development but are also important in maintaining healthy skin. They create a barrier that helps prevent moisture loss keeping skin hydrated, plump, and supple. The barrier also protects the skin from harmful irritants, bacteria, and other environmental toxins.

Learn more about the skin and its structure here.

Ceramides have multiple benefits for skin health.

The natural aging process and the overuse of harsh soaps or exfoliants can lead to ceramide loss in the skin.

When ceramide levels decline, the stratum corneum or protective outer barrier of the skin becomes compromised, and tiny cracks can form. This breakdown in the skin barrier can make it easier for infection and skin inflammation to occur.

Replenishing lost ceramides keeps the skin barrier healthy and functioning as it should.

Ceramides can lock in moisture and boost hydration. When skin is dehydrated, it can become rough, and cracks can develop.

When the skins barrier becomes compromised, it can lead to transepidermal epidermal water loss (TEWL). This water loss refers to the amount of water that passes through the epidermis, a layer in the skin, and evaporates on the skins surface. As a result of TEWL, the skin may then become dry and inflamed with an increased risk of developing inflammatory conditions such as psoriasis, acne, and eczema.

Research shows that ceramide cream can significantly decrease TEWL, which, in turn, boosts skin hydration and improves barrier function.

Some studies also suggest that using ceramide moisturizers in conjunction with acne treatment can help combat the dry skin and irritation these treatments cause.

Increasing hydration also helps soften and smoothen the skin, which improves its overall look and feel.

As people age, their skin changes as it loses structural proteins, such as collagen, elastin, and keratin. This, and the other processes involved in the degradation of the skin barrier, leads to thinner skin and visible signs of aging such as wrinkles, lines, and sagging.

Ceramides have water-retaining properties that prevent moisture loss from the skin. Hydrated skin can help minimize the appearance of fine lines and wrinkles, which are often more visible when the skin is dry.

Ceramide creams can also stimulate the production of keratinocytes, which make keratin. The increase of keratin helps rejuvenate the skin barrier and reduce signs of aging.

Exposure to sunlight and UV rays is responsible for 90% of the visible skin changes such as wrinkles, fine lines, and pigmentary changes. Dermatologists refer to this as photoaging, and it is the direct result of cumulative sun damage over a lifetime.

A 2021 study found that using ceramide-containing moisturizers and sunscreens can protect the skin against UV damage to the skin barrier. In addition, the products seemed to improve skin hydration, help maintain normal cell turnover, and combat redness and hyperpigmentation.

Topical ceramides typically work well for most skin types, are safe for most people, and are not likely to cause side effects.

However, individuals should be aware that certain cosmetic products often contain multiple ingredients besides ceramides.

Therefore, as with any new addition to a skin care routine, performing a patch test before using it on a large area is good practice. This involves applying a small amount of product on an area of skin and waiting 24 hours for any reaction.

People should be aware that ceramide dietary supplements may contain allergens, such as gluten, soy nuts, or fish.

Natural ceramides are found in the skin, whereas skin care products can contain synthetic ceramides.

Plant-derived ceramides can support skin ceramides and are chemically similar. Foods that may contain ceramides include:

Various products contain ceramides, including:

Ceramides 2 and 3 often appear in the ingredients labels of products designed for the face and neck.

Ceramides may appear as ceramide AP, ceramide EOP, ceramide NG, ceramide NP, ceramide NS, and phytosphingosine, in the ingredients list of over the counter products. The label may also list sphingosine, an organic chemical compound involved in making ceramides.

Ceramides are lipids that play a central role in skin structure. They improve the barrier function, which helps prevent moisture loss and keeps the skin hydrated and supple.

The skin barrier also protects the body from harmful pathogens, irritants, and environmental toxins. Therefore, infections and other skin conditions can develop if it is compromised.

As people age, they naturally lose ceramides. However, a person can boost ceramide levels through topical ceramide creams or dietary supplements. These products may help improve skin health, boost barrier function and hydration, protect against harmful UV rays, and rejuvenate aging skin.

Typically, ceramides are safe. They are not likely to cause serious side effects. Although before using, people should perform a patch test on a small area of skin to check if they are sensitive to any ingredient in the product.

Excerpt from:
What are the benefits of ceramides for the skin? - Medical News Today