Category Archives: Eczema

A Skin Lymphoma Diagnosis After 20 Years of Suffering

Its itchy; the itching is so bad that I have to keep my nails short; I need to take anti-histamines because I wake up with blood all over my covers due to the fact Ive been scratching myself in the middle of the night.

That is how Vivian Neill, 43, describes the rash that has covered her body for the past 20 years.

The mother-of-two assumed she was dealing with an aggressive case of eczema until the rash started to change colors in 2018, prompting her to visit with her doctor.

A biopsy soon revealed that Neill had not been dealing with eczema for the past two decades but rather a rare and incurable form of skin lymphoma known as cutaneous T-cell lymphoma.

This is one of the very few lymphomas that are found in the skin. There is no cure for the disease at this time, and it can be fatal if tumors start to develop.

The condition affects the skin; it looks like eczema, but what it does is that too many white blood cells are getting produced in my body, but its worse than eczema. It inflames, Neill said of the rash in an interview with Daily Record.

Ive got it over 90% of my body, Ive got red patches everywhere, my whole back is just a big massive patch, it inflames like hives so it can be really, really sore to the point that I cant even put clothes on.

Related: Shattered Mother Says Daughter, 27, Died From Stage IV Cancer After Doctors Insisted She Had Long COVID Despite Negative Tests

Neill said that she struggled in the wake of her surprise diagnosis, in large part because her doctor informed her that she would be living with this condition for the rest of her life.

I was in a very, very bad place after I was diagnosed, and I was very depressed, explained Neill of her mindset after the skin lymphoma diagnosis. I didnt even bother coming out of my bed for about six months, but then I decided to give myself a kick up the butt.

Neill began taking walks to get out of the house and found herself often visiting the peacocks that reside in a local park. She now volunteers at the park, allowing her to spend her free time with the majestic birds.

I cant work anymore; Im not able to have a relationship for the last five or six years because Ive got to concentrate on myself, pointed out Neill. Sometimes I have good and bad days, the fatigue can hit me like a wall, sometimes I stay in bed for four or five days cause I feel sick.

She said that fatigue along with itching and hot flashes are the most difficult things to deal with, especially because they often come without warning.

Neill is taking an oral chemotherapy treatment and will soon be undergoing radiation to dull the effects of the rash caused by her skin lymphoma.

The procedure is called Total Skin Electron Beam Therapy (TSEBT) and it works to kill the white blood cells that are causing the rash that covers her body.

Neill does not deny the reality of the situation, though, noting: Im still going to have the cancer, Im always going to have the cancer, but I want it to be monitored and managed and not cause me as much pain.

TSEBT is a form of radiotherapy that treats the entire skin surface using low-energy beams generated by a linear accelerator.

The beams can only penetrate the skin, meaning that there is no risk of damaging any of the internal organs.

The treatment has successfully treated patients with cutaneous T-cell lymphoma for some time, but it is often used as a last resort after all other treatment options have been exhausted.

How Focused Radiotherapy Treatments Work

Neill is sharing her experience to help other women who may be unsure about symptoms, reminding them that they know their bodies best.

You will know your own body, and if you feel like something is off, like I did for years, push the doctors that little bit more and dont just take their word for it that their diagnosis is right just because they are from the medical profession, stressed Neill.

I am living proof that docs can be wrong for many years, and I am just glad that one (doctor) that took that little bit more time to look at my skin and sent me for a biopsy rather than just flinging more cream at me without even looking my skin over.

Related: Mother With Terminal Cancer Needs Her Lung Drained at the ER But Fears Contracting Covid And Dying: The Brutal Choices Facing Cancer Patients

When Shelia Johnson was diagnosed with cutaneous T-cell lymphoma, she headed straight for the kitchen.

Learn more about SurvivorNet's rigorous medical review process.

Chris is a senior reporter at SurvivorNet. Read More

That is how Vivian Neill, 43, describes the rash that has covered her body for the past 20 years.

A biopsy soon revealed that Neill had not been dealing with eczema for the past two decades but rather a rare and incurable form of skin lymphoma known as cutaneous T-cell lymphoma.

This is one of the very few lymphomas that are found in the skin. There is no cure for the disease at this time, and it can be fatal if tumors start to develop.

The condition affects the skin; it looks like eczema, but what it does is that too many white blood cells are getting produced in my body, but its worse than eczema. It inflames, Neill said of the rash in an interview with Daily Record.

Ive got it over 90% of my body, Ive got red patches everywhere, my whole back is just a big massive patch, it inflames like hives so it can be really, really sore to the point that I cant even put clothes on.

Related: Shattered Mother Says Daughter, 27, Died From Stage IV Cancer After Doctors Insisted She Had Long COVID Despite Negative Tests

Neill said that she struggled in the wake of her surprise diagnosis, in large part because her doctor informed her that she would be living with this condition for the rest of her life.

I was in a very, very bad place after I was diagnosed, and I was very depressed, explained Neill of her mindset after the skin lymphoma diagnosis. I didnt even bother coming out of my bed for about six months, but then I decided to give myself a kick up the butt.

Neill began taking walks to get out of the house and found herself often visiting the peacocks that reside in a local park. She now volunteers at the park, allowing her to spend her free time with the majestic birds.

I cant work anymore; Im not able to have a relationship for the last five or six years because Ive got to concentrate on myself, pointed out Neill. Sometimes I have good and bad days, the fatigue can hit me like a wall, sometimes I stay in bed for four or five days cause I feel sick.

She said that fatigue along with itching and hot flashes are the most difficult things to deal with, especially because they often come without warning.

Neill is taking an oral chemotherapy treatment and will soon be undergoing radiation to dull the effects of the rash caused by her skin lymphoma.

The procedure is called Total Skin Electron Beam Therapy (TSEBT) and it works to kill the white blood cells that are causing the rash that covers her body.

Neill does not deny the reality of the situation, though, noting: Im still going to have the cancer, Im always going to have the cancer, but I want it to be monitored and managed and not cause me as much pain.

TSEBT is a form of radiotherapy that treats the entire skin surface using low-energy beams generated by a linear accelerator.

The beams can only penetrate the skin, meaning that there is no risk of damaging any of the internal organs.

The treatment has successfully treated patients with cutaneous T-cell lymphoma for some time, but it is often used as a last resort after all other treatment options have been exhausted.

How Focused Radiotherapy Treatments Work

Neill is sharing her experience to help other women who may be unsure about symptoms, reminding them that they know their bodies best.

You will know your own body, and if you feel like something is off, like I did for years, push the doctors that little bit more and dont just take their word for it that their diagnosis is right just because they are from the medical profession, stressed Neill.

I am living proof that docs can be wrong for many years, and I am just glad that one (doctor) that took that little bit more time to look at my skin and sent me for a biopsy rather than just flinging more cream at me without even looking my skin over.

Related: Mother With Terminal Cancer Needs Her Lung Drained at the ER But Fears Contracting Covid And Dying: The Brutal Choices Facing Cancer Patients

When Shelia Johnson was diagnosed with cutaneous T-cell lymphoma, she headed straight for the kitchen.

Learn more about SurvivorNet's rigorous medical review process.

Chris is a senior reporter at SurvivorNet. Read More

Read the original here:
Mother, 43, Discovers Rashes Covering Her Body Are Not Eczema But Incurable Skin Lymphoma: I Am Living Proof That Docs Can Be Wrong For Many Years -...

Dupixent (dupilumab) is a prescription brand-name medication. Its approved by the Food and Drug Administration (FDA) to treat the following in certain situations:

Youll likely take Dupixent long term if you and your doctor agree that the drug is working for your condition.

Here are some fast facts about Dupixent:

Like other drugs, Dupixent can cause side effects. Read on to learn about potential common, mild, and serious side effects. For a general overview of Dupixent, including details about its uses, see this article.

Dupixent can cause certain side effects (also known as adverse effects), some of which are more common than others. These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Dupixent in clinical studies. These side effects can vary depending on the condition the drug is being used to treat.

More common side effects in people taking Dupixent for atopic dermatitis (eczema) include:

More common side effects in people taking Dupixent for rhinosinusitis with nasal polyps include:

More common side effects in people taking Dupixent for asthma include:

* For details, see Eye-related side effects in the Side effect specifics section below. For more information, see Eosinophilic conditions in the Side effect specifics section below.

Mild side effects can occur with Dupixent. This list doesnt include all possible mild side effects of the drug. For more information, you can refer to Dupixents patient information.

Mild side effects that have been reported with Dupixent include:

These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking Dupixent and want to tell the FDA about it, visit MedWatch.

* For details, see the Side effect specifics section below. For more information, see Eosinophilic conditions in the Side effect specifics section below.

Dupixent may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to Dupixents patient information.

If you develop serious side effects while taking Dupixent, call your doctor right away. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported with Dupixent include:

* For details about this, see the Side effect specifics section below.

A clinical study showed that side effects from Dupixent were similar whether the drug was used short term or long term.

Most side effects that Dupixent causes are short term. But in rare cases, the drug can cause side effects that may be long lasting. These include eye-related side effects, such as changes in vision and new or worsening eye conditions. The side effects also include vasculitis (swelling and inflammation of blood vessels).

For more information about eye-related side effects and vasculitis, see the Side effect specifics section below.

Dupixent may cause several side effects. Here are some frequently asked questions about the drugs side effects and their answers.

Its unlikely youll gain weight as a side effect from using Dupixent. People using the drug in its original clinical studies didnt report weight gain.

Since the drug was approved, a very small study found a possible link between weight gain and Dupixent treatment in people with atopic dermatitis (eczema). But more research is needed to determine whether Dupixent or a different factor caused the weight gain in the people.

Some other drugs that treat the same conditions Dupixent is prescribed for can cause weight gain. These other drugs include corticosteroids such as prednisone (Rayos, Prednisone Intensol).

If you have questions or concerns about weight gain or your Dupixent treatment, talk with your doctor.

People using Dupixent in clinical studies didnt report hair loss as a side effect.

But since Dupixent was approved, there have been rare reports of people experiencing hair loss after using the drug.

On the other hand, Dupixent has been found to reduce hair loss in some people. Research has looked at people with atopic dermatitis, and a condition called alopecia areata (a genetic cause of hair loss). Dupixent reduced both hair loss and atopic dermatitis. Because of this information, the drug is being studied to see if it can treat hair loss.

At present, its not known if Dupixent can cause hair loss or if the drug may treat hair loss. If youd like to learn more about Dupixent and hair loss, talk with your doctor or pharmacist.

Its not likely that youll have fatigue (low energy) as a side effect of taking Dupixent. People using the drug in clinical studies didnt report having fatigue.

But fatigue is a side effect of a similar drug called mepolizumab (Nucala). Mepolizumab is approved to treat severe eosinophilic asthma.

If you have questions or concerns about your energy level while taking Dupixent, talk with your doctor or pharmacist. They may be able to suggest ways to help boost it.

More common side effects in people taking Dupixent for asthma include:

For a full list of side effects Dupixent may cause in people with asthma, you can view the drugs prescribing information. You can also ask your doctor or pharmacist.

* For more information, see Eosinophilic conditions in the Side effect specifics section below.

Its unlikely youll experience headaches as a side effect from using Dupixent. People using the drug in clinical studies didnt report having headaches.

But headache is a side effect of similar drugs called Fasenra (benralizumab) and Nucala (mepolizumab). These two drugs are approved to treat severe eosinophilic asthma.

If you have questions or concerns about headaches while taking Dupixent, talk with your doctor or pharmacist.

No, cancer isnt known to be a side effect of Dupixent. People using the drug in its clinical studies didnt report developing cancer.

But another drug used to treat asthma, Xolair (omalizumab), may increase your risk of certain types of cancer. These include breast cancer and skin cancer.

If you have concerns about your risk of cancer or questions about Dupixent, talk with your doctor or pharmacist.

Learn more about some of the side effects that Dupixent may cause.

Dupixent could cause ocular (eye-related) side effects, including:

Eye-related side effects werent common in clinical studies.

Symptoms of these side effects can include eye redness, discharge, pain, and watery eyes.

If you experience symptoms of eye-related side effects while taking Dupixent, talk with your doctor immediately. They can help determine the right treatment. This may include having you stop using Dupixent.

* To learn more, see the Precautions for Dupixent section below.

Although joint pain isnt common with Dupixent, it can still occur. This side effect was reported in clinical studies by some people who used the drug for long-term rhinosinusitis with nasal polyps.

People who used Dupixent for atopic dermatitis (eczema) or asthma didnt report joint pain as a side effect.

If you have joint pain while using Dupixent, talk with your doctor. They may be able to recommend a treatment, such as an over-the-counter pain reliever. But if your joint pain doesnt go away, they may recommend you stop using Dupixent.

Eosinophilic conditions are a rare side effect of Dupixent when the drug is used to treat asthma. Examples of eosinophilic conditions are pneumonia and vasculitis (swelling and inflammation in your blood vessels).

Eosinophils are a type of white blood cell that help your body fight infection. Having high levels of eosinophils can cause problems with inflammation.

Symptoms of eosinophilic conditions can include:

If you develop any symptoms linked to eosinophilic conditions while using Dupixent, talk with your doctor right away. If your symptoms feel life threatening or you think youre having a medical emergency, call 911 or your local emergency number right away.

As with most drugs, Dupixent can cause an allergic reaction in some people. This side effect was rare in clinical studies of the drug.

An allergic reaction is different from an injection site reaction, which can occur where you inject Dupixent. With an injection site reaction, you may have symptoms such as pain and swelling.

Symptoms of an allergic reaction can be mild or serious and can include:

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking Dupixent. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number.

Be sure to talk with your doctor about your health history before you take Dupixent. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. The conditions and factors to consider include:

Parasitic infection. Dupixent may reduce your immune systems ability to fight a parasitic infection. If you have a parasitic infection (such as a tapeworm), it will need to be treated before you can use Dupixent. Your doctor can give you more information about parasitic infection and possible treatment options.

Asthma attack. Dupixent cannot be used to treat sudden asthma attacks. Dupixent can help relieve asthma symptoms, so you have fewer and less severe asthma attacks. But the drug does not treat asthma attacks themselves.

Allergic reaction. You should not use Dupixent if youve ever had an allergic reaction to Dupixent or any of its ingredients. Talk with your doctor about which other treatments are better choices for you.

There are no known interactions between consuming alcohol and taking Dupixent.

But alcohol may worsen the conditions Dupixent is used to treat. For this reason, talk with your doctor about your condition and how alcohol may affect it. They can offer advice about how much alcohol is safe for you to consume.

Heres some information about pregnancy, breastfeeding, and Dupixent treatment.

Pregnancy. Its not known whether its safe to use Dupixent while pregnant. If you and your doctor agree that using the medication is the best option for you while pregnant, you may want to join a pregnancy registry. The registry monitors the health of people who use Dupixent during pregnancy. To learn more or sign up, call 877-311-8972 or visit the registry website. You can also talk with your doctor.

Breastfeeding. Its not known whether Dupixent passes into human breast milk or is safe to use while breastfeeding. Your doctor can advise you on the pros and cons of the medication. They can also recommend healthy feeding options for your child.

Like most medications, Dupixent may cause side effects. Most side effects caused by Dupixent are mild and typically go away on their own. However, there are some rare but serious side effects reported by people using the drug in clinical studies.

If youd like to learn more about Dupixent, talk with your doctor or pharmacist. They can help answer any questions you have about side effects of taking the drug.

Besides talking with your doctor, you can do some research on your own. These articles might help:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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Dupixent: Side effects and what to do about them - Medical News Today

PORTSMOUTH, N.H., Sept. 15, 2021 /PRNewswire/ -- WaterWipes, the world's purest baby wipes, has launched ABCs of Baby Skin, a comprehensive and dermatologist-approved resource to help parents access trusted information as they care for their babies' delicate skin.

New and expectant parents often feel unprepared and not fully equipped to recognize common baby skin conditions such as diaper rash, eczema, baby acne, cradle cap, milk spots and teething rash. In fact, research by WaterWipes found that when their baby has diaper rash, one of the most common baby skin conditions1, 56% of parents are worried their baby is in distress or pain. With the ABCs of Baby Skin, WaterWipes hopes to reassure and empower parents to recognize and help support their baby if they experience a common skin condition.

The collection of 26 baby skin-related topics (one for each letter of the alphabet), provides parents with practical advice and expert videos on how to identify and manage some of the most common baby skin conditions. All content is validated by consultant dermatologist, Dr. Alexis Granite, to provide parents with medically accurate and robust guidance on how to look after their babies' skin, no matter how sensitive it might be. Parents can access the resource at abc.waterwipes.com.

"Looking after your little one's skin can be a challenge, especially as there are so many different baby skin conditions out there," said Dr. Granite. "If your baby or toddler experiences an unexpected mark or rash, it can sometimes leave you feeling overwhelmed or confused. Most baby skin conditions are perfectly normal, and with the right support, parents can feel empowered to identify and look after their little one's skin. With the launch of WaterWipes' ABCs of Baby Skin resource, parents have access to practical advice at their fingertips. Of course, if parents are ever worried, they should speak to their healthcare professional."

Story continues

"As a company we recognize the many challenges that parents face and looking after their babies' delicate skin is one of these," said Eimear Gorman, Brand Acceleration Director, WaterWipes North America. "That's why, we are delighted to launch the WaterWipes ABCs of Baby Skin resource. At WaterWipes, we want parents to feel empowered that they can do the best for their babies' skin, and we are committed to helping provide parents with advice to help them do just this; as well as provide the best products to gently care for and protect their babies' sensitive skin."

WaterWipes are available in the United States and Canada across all major retailers.

For more information, visit: abc.waterwipes.com.

Media ContactsMichelle Sachsmichelle.sachs@thebrooklynbrothers.com (908) 655-8359

1The parenting survey was conducted by OnePoll research amongst 8,000 respondents from UK, ROI, USA, Canada, Australia, New Zealand, France, Portugal, Spain, Italy, Germany and the UAE. All respondents were parents of at least one child aged 0-2 years old. The research fieldwork took place between April 14th 26th, 2021.

About WaterWipesWaterWipes, the world's purest baby wipes, made using unique water technology, contain just two ingredients, 99.9% purified water and a drop of fruit extract. They have been specifically developed to be purer than cloth and water while offering the convenience of a wipe. They provide gentle cleansing for the most delicate newborn skin and even premature babies' skin.

*WaterWipes is a cosmetic product, not intended to diagnose, treat, cure or prevent any medical condition.

About the ABCs of Baby Skin The ABCs of Baby Skin has been launched by WaterWipes to provide practical advice on how to care for baby's most common skin conditions, no matter how sensitive their baby's skin might be.

Please note, the information provided should not be considered a diagnostic tool. For any concerns, parents are advised to speak directly to their healthcare provider.

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WaterWipes, The World's Purest Baby Wipes, Launches the 'ABCs of Baby Skin' to Alleviate Stress & Empower Parents to Feel Confident Caring for...

1.Plain Language SummaryKey Message

The Medicines and Healthcare products Regulatory Agency (MHRA) and the Commission on Human Medicines (CHM) has reviewed the available safety evidence for the risk of topical steroid withdrawal reactions, which have been associated with the use of topical corticosteroids.

This review has concluded that when used correctly, topical corticosteroid medicines are safe and effective treatments for skin disorders. However, if used very often or continually for a prolonged time, there have been reports of withdrawal reactions after they are stopped. A particularly severe type of topical steroid withdrawal reaction has been reported with skin redness (or a spectrum of colour changes or change in normal skin tone) and burning worse than the original condition.

It is important to follow the advice provided with topical corticosteroid medicines and to contact your doctor if your skin condition doesnt improve or gets worse, including after you stop using a topical corticosteroid.

Steroids are natural chemicals produced by the body and also are manufactured to be used as medicines. There are different types of steroids. The most common type used to treat skin disorders are the corticosteroids.

If a corticosteroid is used on the skin, this is known as a topical corticosteroid. These may come in the form of creams, ointments, lotions, mousses, shampoos, gels or tapes.

Topical corticosteroids may be used to treat skin disorders such as:

Examples of topical corticosteroid medicines include beclometasone, betamethasone, clobetasol, hydrocortisone, mometasone, and triamcinolone.

The MHRA received an enquiry from a patient representative to the Yellow Card scheme about the risk of topical steroid withdrawal reactions, which triggered this assessment.

We conducted a comprehensive review of the evidence available. We considered side effects reported to us by patients and healthcare professionals, in addition to information published by researchers and other medicines regulators. We considered whether action should be taken to reduce the risk of these events.

We also sought advice on the review from our experts and from dermatologists and skin charities. The findings and recommendations of the review are summarised in this report.

When used correctly, topical corticosteroid medicines are safe and effective treatments for skin disorders. Correct use includes using these medicines to treat certain skin conditions for short periods of time, or with short breaks in treatment over an extended period.

There is growing evidence of topical steroid withdrawal reactions if they are used continually for a long time. We are unable to estimate the frequency of these reactions. However, given the number of patients who use topical corticosteroids, we understand that these effects occur very infrequently. however they can be debilitating and long lasting.

Information about these reactions will be added to the product information provided to healthcare professionals and patients. We have also produced additional materials for patients and healthcare professionals about the best way to minimise the risks of these reactions with topical corticosteroids and what to do if they occur.

The Medicines and Healthcare products Regulatory Agency (MHRA) is the government agency responsible for regulating medicines and medical devices in the UK. We continually review the safety of all medicines in the UK and inform healthcare professionals and the public of the latest updates. The Commission on Human Medicines (CHM) advises government ministers and the MHRA on the safety, efficacy and quality of medicines.

The aim of our Safety Public Assessment Reports is to discuss evidence-based assessments of safety issues for a particular drug or drug class.

The following report provides a summary of the review of available safety data regarding topical steroid withdrawal reactions, which have been associated with topical corticosteroid medicines. A glossary is provided for an explanation of the terms used in this report.

We received an enquiry to the Yellow Card scheme regarding red skin syndrome, which triggered this assessment. Red skin syndrome is a term used by patients for side effects seen after stopping topical corticosteroids that were used for prolonged periods of time. These reactions are also referred to as steroid addiction, topical steroid withdrawal, red burning skin, and steroid dermatitis. In this report, we use the term topical steroid withdrawal reactions.

Topical corticosteroids are used to treat the symptoms of many skin disorders, such as eczema, dermatitis, and psoriasis. Topical corticosteroids may also be combined with other medicines to treat bacterial or fungal infections.

Examples of topical corticosteroid medicines include beclometasone, betamethasone, clobetasol, hydrocortisone, mometasone, and triamcinolone.

Topical corticosteroids are available in multiple forms including creams, lotions, gels, mousses, ointments, or solutions. They are commonly used treatments for many dermatological conditions and are generally considered very safe and effective.

Mild corticosteroids, such as hydrocortisone, can be bought over the counter from pharmacies for use in older children and adults, whereas stronger or more potent types of corticosteroids are only available on prescription. Corticosteroids for skin problems in children younger than 10 years are available only on prescription.

Topical steroid withdrawal reactions have been reported in long-term users of topical corticosteroids after they stop use (Rapaport and Lebwohl, 2003; Hajar and others, 2015; Gust and others, 2016; Sheary 2016 and 2018). Symptoms noted include redness of the skin, a burning sensation, and itchiness. This may then be followed by skin peeling (Gust and others, 2016), which appears to be distinct from a flare-up of the underlying condition.

At the time of the review, topical steroid withdrawal reactions were not acknowledged as a side effect of corticosteroids in commonly used UK clinical materials and patients described to the MHRA encountering difficulties with diagnosis.

Topical corticosteroids are safe and highly effective treatments when used correctly. As with any medicine, topical corticosteroids can cause side effects, although not everybody gets these.We conducted a comprehensive review to assess the evidence available. We considered data from Yellow Card reports, in addition to information from the published literature and other medicines regulators. The review considered whether regulatory action was needed to minimise the risk of these events.

We sought advice and endorsement on the assessment from the Gastroenterology, Rheumatology, Immunology and Dermatology and Pharmacovigilance Expert Advisory Groups of the Commission on Human Medicines. Clinical experts in dermatology and skin charities were invited to participate in these discussions.

The findings and recommendations of the review are summarised in this report.

The Yellow Card scheme run by the MHRA is the UK system for collecting and monitoring information on safety concerns such as suspected side effects involving medicines. Suspected side effects are reported by health professionals and the public, including patients, carers and parents. All Yellow Card reports received are entered onto the MHRAs adverse drug reaction database so that they are available for signal detection.

We aimed to identify suspected spontaneous reports of topical steroid withdrawal reactions associated with topical corticosteroids on the Yellow Card database.

It is important to note that a reported reaction or case does not necessarily mean it has been caused by the drug or vaccine, only that the reporter had a suspicion it may have. Underlying or concurrent illnesses may be responsible and such events can also be coincidental. Additionally, it is also important to note that the number of reports received via the Yellow Card scheme does not directly equate to the number of people who suffer adverse reactions, and therefore cannot be used to determine the incidence of a reaction. Adverse drug reaction reporting rates are influenced by the seriousness of these reports, their ease of recognition, the extent of use of a particular drug or vaccine and may be stimulated by promotion and publicity about a drug or vaccine.

Identifying cases in the database was challenging because there is no official recognition of topical steroid withdrawal reactions and the MedDRA clinical coding system does not currently include topical steroid withdrawal reactions or other related terms. Therefore, we searched for possible cases in association with a number of different topical corticosteroids (beclometasone, betamethasone, clobetasol, hydrocortisone, mometasone, triamcinolone) using the below MedDRA search criteria:

The search included Yellow Cards reported between 1963 (inception of the database) and 29 January 2020.

The criteria for narrowing down these cases to definitive cases of topical steroid withdrawal reactions are difficult since many of the symptoms are listed individually for topical corticosteroids and some cases may be not related to these reactions. Additionally, rebound psoriasis is listed and although similar, this term does not fully capture topical steroid withdrawal reactions, which also occur outside the context of psoriasis. Therefore, only cases that have a clear timeline of worsening symptoms or increasing use of stronger steroids or multiple symptoms were included.

There may be more cases within the MHRA Yellow Card database that are potentially topical steroid withdrawal reactions, but due to a lack of information we cannot determine them as such at this time.

For the purposes of this review, cases that were considered indictive of topical steroid withdrawal reactions were referred to as probable cases by the lead MHRA reviewers. There are also some cases that could be considered topical steroid withdrawal reactions, but lack sufficient information to be determined as probable and so these have been classed as possible cases. It should be noted that this does not refer to whether the reactions were directly caused by the medicine.

We identified 55 reports categorised as probable topical steroid withdrawal reactions in the Yellow Card database and a further 62 cases of possible topical steroid withdrawal reactions.

It is important to note that some of the cases may be listed for multiple steroids as often patients are switched by healthcare professionals from one product to another in increasing strength to try and resolve the symptoms. As a result, the numbers of cases for each steroid medicine in Table 1 are not directly comparable, and a higher number of reports should not be interpreted as a larger risk being present for individual steroid medicines.

Assessment of information provided by these reports is provided in Discussion.

We aimed to identify relevant published scientific studies or reports about topical steroid withdrawal. To identify relevant papers, the PubMed search engine was used to identify citations from MEDLINE, life science journals, and online books published up to February 2020.

Search terms used were red skin syndrome, burning skin, and topical corticosteroids, withdrawal. Dates of inclusion were studies published up to February 2020. No other date limiters were used. Only papers referring to reactions on withdrawal of topical corticosteroids were reviewed; all other papers were excluded. Only English-language papers were reviewed.

There are difficulties in identifying information on topical steroid withdrawal reactions within the published literature due to different terminologies being used and a lack of recognition of the issue. This is perhaps to be expected as topical steroid withdrawal reactions may be under-recognised.

The following papers were identified:

Rapaport (1999) had previously reported on 100 patients with chronic eyelid dermatitis, which did not resolve until all topical and systemic corticosteroids had been discontinued. All patients had been treated with topical corticosteroids in the long term, often with escalating dosage and frequency of application. In many cases a severe burning sensation was the main characteristic reported. Patch testing did not reveal any allergens.

In their 2003 paper, Rapaport and Lebwohl present cases in which other body areas were affected, including cases of burning face syndrome, red scrotum syndrome, and chronic eczema. The authors concluded that in all of these cases, corticosteroids had been applied long term and resulted in a characteristic pattern of corticosteroid addiction.

The authors state that when dermatitis first developed, many of the patients self-prescribed over-the-counter 1% hydrocortisone cream or ointment. For those who sought medical consultation, many had been given moderate-strength corticosteroids initially, but in the recent years before publication, potent corticosteroid preparations were commonly prescribed at the outset. When pruritus or rash persisted or when rash recurred, stronger corticosteroids or more frequent application had been recommended.

The authors described that in the initial phases, the corticosteroids were usually effective, and patients felt relief for weeks to months. However, as time passed many patients required systemic corticosteroids at increasingly frequent intervals, some every 6 to 10 weeks. Daily topical treatment only maintained tolerance of symptoms and mild diminution of the rash. Patients complained that corticosteroids were not working anymore. The authors stated that by this point, the initial limited areas of dermatitis had expanded significantly. The itch had mostly disappeared but had been replaced by severe burning, which was only relieved by further topical corticosteroid application. The appearance of the dermatitis changed and was more of a hyperaemia.

Cork and colleagued reviewed evidence for epidermal barrier dysfunction in atopic dermatitis. They postulated that topical corticosteroids disrupt the epidermal barrier causing an initiation of cytokine cascade followed by an inflammatory response. This was suggested as a possible mechanism of rebound flare in atopic dermatitis, which is not uncommon. The authors cite red burning syndrome as an extreme form of rebound flare and that this is further exacerbated by continued use of topical corticosteroids.

The authors proposed a possible mechanism could be that a potent topical corticosteroid causes a thinning of the naturally thin stratum corneum on the face. They postulated that this increased thinning allows more allergens to penetrate, inducing persistent flares of the atopic dermatitis. As a result, the patient uses more topical corticosteroid to treat the flare, but this causes further thinning of the stratum corneum and, consequently, greater allergen penetration, causing more flares. A vicious circle is therefore established.

Following an increasing number of patient enquiries to the National Eczema Society, Hajar and colleagues sought to review the current evidence regarding addiction and withdrawal of topical steroid withdrawal. Cases without a clear temporal association were excluded, as were case series without a definitive number of cases and reviews of expert opinion.

Overall 34 case series were identified, all of which were deemed to be of very low quality, with the oldest article published in 1969 and the most recent in 2013. However, the papers contained information on 1,207 cases of topical steroid withdrawal reactions.

The authors concluded that topical steroid withdrawal generally occurs after prolonged or inappropriate use of topical corticosteroids. They divided topical steroid withdrawal reactions into 2 distinct morphologic syndromes: erythematoedematous and papulopustular.

They reported that the erythematoedematous type develops more frequently in patients who have underlying chronic eczematous conditions such as atopic dermatitis and seborrheic dermatitis; is characterised by erythema, scaling, and oedema; and is generally accompanied by a burning sensation. The papulopustular type is more common in patients who are using topical corticosteroids for pigmentary disorders or acneiform conditions.

They reported that the papulopustular withdrawal subtype is more likely in patients who develop steroid rosacea, but this is not a prerequisite condition for this subtype. The papulopustular variant can be differentiated from the erythematoedematous subtype by the prominent features of pustules and papules, along with erythema, but less frequently swelling, oedema, burning, and stinging.

The authors state that care should be taken since confusing the signs and symptoms of atopic dermatitis for steroid withdrawal could lead to unnecessary withholding of necessary anti-inflammatory therapy. However they state that a clinician should favour a diagnosis of topical steroid withdrawal over a flare-up of the underlying atopic dermatitis if:

The authors also highlight the issue of nomenclature with the following names used to describe this entity: facial corticosteroid addictive dermatitis, red skin syndrome, topical corticosteroid induced rosacea-like dermatitis, steroid addiction syndrome, steroid withdrawal syndrome, steroid dermatitis, post-laser peel erythema, status cosmeticus, red scrotum syndrome, chronic actinic dermatitis, anal atrophoderma, chronic eczema, corticosteroid addiction, light-sensitive seborrheid, perioral dermatitis, rosacea-like dermatitis, steroid rosacea, and steroid dermatitis resembling rosacea.

Juhasz and others (2017) is a follow-up paper to the review by Hajar (2015); specifically looking at topical steroid withdrawal in children. The study reviewed the literature and social media.

The authors literature search yielded no studies on or reporting classic topical steroid withdrawal reactions in children. However, periorificial dermatitis, which is generally a steroid-induced disorder in children, was reported in more than 320 cases.

Of 142 social media blogs on topical steroid withdrawal reactions, 26 were blogs discussing children, the majority of these (18) were from the USA, with 4 being from the UK. The review included 27 cases.

Duration of topical steroid use ranged from 2 months to 12 years. 56% of children had been prescribed topical steroids at 12 months of age or younger. Of the 11 types of topical steroids initially prescribed, 73% were of the mid-potency to high-potency class, with 30% being over-the-counter hydrocortisone. Despite signs and symptoms, only 6 cases (22%) reported that a medical provider had given them the diagnosis of topical steroid addiction or topical steroid withdrawal reactions. All caregivers provided their children with treatment for topical steroid addiction or withdrawal symptoms, which included discontinuation of topical corticosteroid use.

The authors concluded that topical steroid withdrawal reactions occur in children and can result from discontinuing topical steroids used for as little as 2 months. The authors reported that resultant signs and symptoms can last longer than 12 months, even with short duration of use. The authors acknowledged the lack of peer reviewed research of topical steroid withdrawal reactions in the paediatric population, nevertheless they concluded that the data indicates a need for guidelines pertaining to the safe use of topical steroids and counselling of patients for the signs and symptoms of topical steroid withdrawal reactions.

This paper by Sheary reviews some individual cases and the literature, including the review by Hajar above. The author concludes that the issue is under recognised and that most cases are caused by prolonged or inappropriate use of topical corticosteroids. The table below is reported as the common features of topical steroid withdrawal reactions.

The author concludes that the safe use of topical steroids is an effective treatment; however, as recommended by the US National Eczema Association, daily use should be limited to 2 to 4 weeks with tapering of use after that.

This paper by Sheary highlighted that concerns about topical steroid withdrawal reactions are leading some patients to cease long-term topical corticosteroid therapy and that diagnostic criteria for this condition do not exist. The author therefore examined the demographics and outcomes in adult patients who believe they are experiencing topical steroid withdrawal reactions following discontinuation of chronic overuse of topical corticosteroids.

This was a retrospective cohort study of patients in an Australian general practice presenting with this clinical scenario between January 2015 and February 2018. Women were 56% of the 55 patients seen, and ages ranged from 20 to 66 years (with a mean age of 32 years; and median age of 30 years). 66% had an original diagnosis of atopic dermatitis. 60% had used potent topical corticosteroids on the face, and 42% had a history of oral corticosteroid use for skin symptoms. Burning pain was reported in 65%; all had widespread areas of red skin; and so-called elephant wrinkles or red sleeve.

The author concluded that patients with a history of long-term topical corticosteroids overuse may experience symptoms and signs described as withdrawal reactions on stopping topical corticosteroids.

We also considered information to prescribers or patients on topical steroid withdrawal reactions from other regulators.

Only Medsafe (New Zealand) had information available to prescribers on topical corticosteroid withdrawal. The information refers to an infrequent rebound effect that can occur once a topical steroid has been discontinued. This reaction can occur after prolonged, inappropriate, and/or frequent use or abuse of moderate-potency to high-potency topical corticosteroids.

Corresponding guidance from the New Zealand Dermatological Society lists the symptoms of topical steroid withdrawal and advises that the higher the potency, the longer the period of application (in other words, more than 1 year), and the more frequent the application (more than once a day), the more likely that withdrawal reactions may occur.

We conducted a comprehensive review to assess the evidence available. We considered data from Yellow Card reports, in addition to information from the published literature and guidance from other medicines regulators.

We identified 55 reports in the Yellow Card database that are probable reports of topical steroid withdrawal reactions and 62 further reported reactions potentially indicative of topical steroid withdrawal reactions.

The cases have been reported over a wide time-period, and the majority of reports are from patients. The terms used for reporting are reactions that are already listed in the product information, which impacts how we detect newly emerging safety concerns to medicines. Since the reports are mostly from patients, most cases use colloquial terminology and have been added to the database with the side effects reported in the case rather than with the term topical steroid withdrawal or withdrawal. Most of these side effects are already listed individually for topical corticosteroids.

The lack of a consistent terminology has also been raised within the literature and has potentially led to the condition being under-represented. Many of the reports we have received have the recurring theme that patients found the information on topical steroid withdrawal reactions for themselves rather than receiving a diagnosis from a healthcare professional.

In some patients, the adverse reactions appear to present while the topical corticosteroid is still being used. These cases may not relate to topical steroid withdrawal reactions and may represent allergic reactions (possibly to multiple topical corticosteroids), patients developing a different skin condition or some form of tolerance. However, this cannot be determined from the information available.

Topical steroid withdrawal reactions are thought to result from prolonged, frequent, and inappropriate use of moderate to high-potency topical corticosteroids. It has been reported that these reactions develop after application of a topical steroid at least daily for more than a year. To date, they have not been reported with normal use, such as treating certain skin conditions for short periods of time, or with short breaks in treatment over an extended period (Rapaport and Lebwohl 2003, Hajar and others, 2015, Juhasz and others, 2017, Sheary, 2018).

People with atopic dermatitis are thought to be most at risk of developing topical steroid withdrawal reactions (Hajar and others, 2015).

Juhasz (2017) reported that the signs and symptoms occur within days to weeks after discontinuation of long-term topical steroid treatment.

The signs of the specific type of topical steroid withdrawal reactions reported by Hajar (2015) and Sheary (2016) are:

Sheary (2018) postulated that the basis for the skin redness seen in these patients is due to an elevation in blood nitric oxide levels, which widens blood vessels, increasing blood flow to the skin. It has also been proposed that topical corticosteroids disrupt the epidermal barrier causing an initiation of cytokine cascade followed by an inflammatory response (Cork and others 2006). Topical corticosteroids are known to constrict blood vessels in the skin and therefore some reddening of the skin would be expected on withdrawal. However, this specific kind of topical steroid withdrawal reaction could be an extreme form of this reaction.

These adverse events are experienced by patients shortly after stopping treatment, with a rebound of the original eczema that then spreads further. A rebound reaction on discontinuation is well recognised in the treatment of psoriasis and this is reflected in the product information of most topical corticosteroids. However, rebound in the context of eczema or atopic dermatitis is not mentioned in the product information of most topical corticosteroids. Rebound reactions may still benefit from treatment with a topical corticosteroid.

In many cases the worsening of the skin condition has been interpreted as a need for stronger topical corticosteroids. It can be difficult to differentiate between a worsening of a condition (which would benefit from the use of topical steroids) and topical steroid withdrawal. However, as stated by Hajar (2015) and identified by our review of the literature, a topical steroid withdrawal reaction should be suspected as distinct from a flare-up of the underlying atopic dermatitis if the following features are present:

From the reports the MHRA has received, patients have stated that they found the diagnosis themselves and that they had difficulty getting a diagnosis from a healthcare professional. This could be due a lack of awareness or a lack of recognition of the condition. As stated by Rathi and Souza (2012), topical corticosteroids are a vital tool for the treatment of dermatological conditions. However, if they are used inappropriately and without adequate supervision, there is a risk of reduced patient confidence and therefore compliance in the use of these products.

Many of the symptoms associated with topical steroid withdrawal reactions are listed individually within the patient information leaflets for topical steroids. These include inflammation and/or infection of the hair follicles, thinning of the skin, red marks with associated prickly heat, loss of skin colour, burning, stinging, itching or tingling.

Even though the current product information for topical corticosteroids may list some of the individual symptoms of topical steroid withdrawal reactions, there is no mention of reactions occurring after cessation of treatment. Therefore, following confirmation that topical steroid withdrawal reactions are a side effect that patients and prescribers need to be aware of, it was considered appropriate to update product information to better reflect the possible reactions that can be experienced.

There is a growing body of evidence that reactions associated with topical steroid withdrawal can occur following long-term or incorrect use of topical corticosteroids, particularly those of moderate to high potency. Correct use includes using these medicines to treat certain skin conditions for short periods of time, or with short breaks in treatment over an extended period.

We are unable to estimate the frequency of these reactions. However, given the number of patients who use topical corticosteroids, we understand reports of severe withdrawal reactions to be very infrequent. There are reports of severe withdrawal reactions taking the form of a dermatitis with intense redness (or a spectrum of colour changes or change in normal skin tone), stinging, and burning that can spread beyond the initial treatment area.

The information provided to both healthcare professionals and patients should reflect these reactions, especially with respect to eczema and dermatitis. Therefore, a strengthening of the information within the product information is considered appropriate, together with communication and consultation with other bodies.

After working with experts in the field and patient representatives, we have requested relevant marketing authorisation holders add the following to their product information:

Section 4.4 Special warnings and precautions for use

Long term continuous or inappropriate use of topical steroids can result in the development of rebound flares after stopping treatment (topical steroid withdrawal syndrome). A severe form of rebound flare can develop which takes the form of a dermatitis with intense redness, stinging and burning that can spread beyond the initial treatment area. It is more likely to occur when delicate skin sites such as the face and flexures are treated. Should there be a reoccurrence of the condition within days to weeks after successful treatment a withdrawal reaction should be suspected. Reapplication should be with caution and specialist advise is recommended in these cases or other treatment options should be considered.

Section 4.8 Undesirable effects

Skin and Subcutaneous Tissue Disorders - Not known (cannot be estimated from available data) Withdrawal reactions - redness of the skin which may extend to areas beyond the initial affected area, burning or stinging sensation, itch, skin peeling, oozing pustules. (see section 4.4)

Section 2 What you need to know before use

If there is a worsening of your condition during use consult your prescriber you may be experiencing an allergic reaction, have an infection or your condition requires a different treatment.

If you experience a recurrence of your condition shortly after stopping treatment, within 2 weeks, do not restart using the cream/ointment without consulting your prescriber unless your prescriber has previously advised you to so. If your condition has resolved and on recurrence the redness extends beyond the initial treatment area and you experience a burning sensation, please seek medical advice before restarting treatment.

Section 4 Possible side effects

Steroid withdrawal reaction:

If used continuously for prolonged periods a withdrawal reaction may occur on stopping treatment with some or all of the following features: redness of the skin which can extend beyond the initial area treated, a burning or stinging sensation, intense itching, peeling of the skin, oozing open sores.

Section 2 What you need to know before use

If your condition worsens during use consult a pharmacist or doctor you may be experiencing an allergic reaction, have an infection or your condition requires a different treatment.

If you experience a recurrence of your condition shortly after stopping treatment, within 2 weeks, do not restart using the cream/ointment without consulting a pharmacist or doctor. If your condition has resolved and on recurrence the redness extends beyond the initial treatment area and you experience a burning sensation please seek medical advice before restarting treatment.

Read the original here:
Topical steroid withdrawal reactions: a review of the evidence - GOV.UK

The human body is pretty incredible. As we learn more about how different parts interact, it becomes even more amazing. There is growing interest in how our gut and skin communicate with each other.

The gut-skin axis refers to all the connections between our skin and digestive system. The skin and digestive tract both interact with our inner and outer environments. This means theyre in constant communication with the world around us and the world inside of us.

Much of this communication is done through our bodys microbiome. Our microbiome includes trillions of bacteria, fungi, and other living things. They live in and on our body, mainly in our gut and on our skin.

These microbes play an important role in our health. An imbalance in either the skin or gut microbes often affects the other. Alterations in the microbiome are seen in a variety of health conditions. These include mental health conditions, irritable bowel syndrome (IBS), diabetes, and skin conditions.

Eczema is an inflammatory skin condition. People with eczema have some distinct differences in their microbiomes. We are still finding out how our microbes can be modified to support better health. The hope is that this information can help to find better treatments for eczema.

Treatment for eczema is no longer just about targeting your skin. Its possible that changing your gut microbiome may improve your skin, too.

The makeup of the microbiome starts from birth. There are a number of factors that influence the colonies that set up residence in your gut and on your skin.

These include:

Theres no one single healthy microbiome. One healthy person will not have the same microbiome as another healthy person.

Research has noted distinct differences in the microbiome of people with certain diseases. Its unclear what happens first.

In babies and children, eczema can be an early sign of allergy risk. Eczema and allergies are both triggered by an abnormal immune response.

The immune system usually only responds to a true threat such as a virus or harmful bacteria. It will send out an army of inflammatory proteins to fight off an invader. With allergies or eczema, the immune system gets triggered by something that shouldnt trigger it.

Babies with eczema are more likely to develop food allergies or asthma. Allergy testing is often recommended for babies and children with eczema. Removing any allergens from the diet will often improve the skin.

Children with eczema have different skin bacteria compared with children without eczema.

Studies of the gut microbiome support the idea that skin and gut health are connected. Children without eczema have more gut microbiome diversity compared with those with eczema. Greater diversity in the gut microbiome is often a sign of better health.

Sometimes children grow out of eczema. In adults, especially older adults, several changes naturally occur in the skin. This alters the skins microbiome to favor more beneficial bacteria. This crowds out many of the inflammatory bacteria associated with eczema. This may explain why some cases of eczema improve with age.

There are theories that changing the gut microbiome could improve eczema. Everyones microbiome is slightly different. Its impossible to know what the perfect microbiome would look like to prevent or manage eczema.

There is also the ongoing question of what comes first. Does something cause a shift in the microbiome, leading to disease? Or does the disease cause a change in the microbiome?

Common treatments for eczema include topical creams or narrow band ultraviolet treatment. These are found to change the skins microbiome. They promote healthy bacteria and reduce inflammatory bacteria on the skin. This relieves eczema symptoms.

You may have heard about fecal transplants. This is when gut bacteria from a healthy donor are delivered into the gut of someone else. Its been done to restore healthy gut bacteria in people with inflammatory bowel disease (IBD) or Clostridium difficile (C. diff) infection.

Skin microbiome transplants may be the next thing. Research is exploring whether it may help to treat eczema. In theory, healthy donor skin bacteria could restore balance to the skin microbiome. There is still more work to do before this becomes a routine practice.

Probiotic supplements can be helpful for people with digestive symptoms. With skin and gut microbes so connected, could oral probiotics also support skin health? There are theories that changing gut bacteria with probiotics may improve skin, too. So far, there are no results to support this idea.

A 2018 Cochrane review explored 39 randomized controlled trials on this topic. The review looked at whether oral probiotics would improve eczema. There were no trials that showed significant improvement in eczema with probiotic supplements.

At this point, theres no specific probiotic supplement to improve eczema. With further research, its possible that could change.

There may be some promise with synbiotics. Synbiotic supplements include both probiotics and prebiotics. Probiotics are the healthy bacteria and prebiotics are food to nourish the probiotics. This combination may increase the odds of certain bacteria thriving in the gut.

A 2016 meta-analysis looked at whether synbiotics could be helpful for those with eczema. It showed that specific synbiotics could help treat dermatitis in children aged 1 year and older. More research is needed to learn whether synbiotics may play a role in eczema prevention.

People with eczema have more Staphylococcus aureus (S. aureus) bacteria on their skin. This bacteria is associated with greater inflammation. The more severe the eczema, the greater amount of S. aureus bacteria are present.

There are several species of helpful bacteria that live on the skin. Many act as barriers to prevent harmful invaders from entering the body. Some bacteria actually have antimicrobial properties to block pathogens. The population of S. aureus makes it harder for beneficial bacteria to live on affected areas of the skin.

There are things that you can do to support gut health. At this point, its not known exactly what the best gut microbiome is for eczema. People with eczema and other inflammatory conditions tend to have less diverse microbiomes.

Certain lifestyle choices can support greater diversity within your microbiome:

We have trillions of bacteria, fungi, and other living things that live in and on our body. This makes up our microbiome. Most of these microorganisms live on our skin and in our gut. These microorganisms are in constant communication. This is known as the gut-skin axis.

Everyones microbiome is a little different and there isnt one perfect microbiome. There are distinct changes seen with certain conditions. People with eczema have different bacteria colonies compared to people without eczema.

There is hope that changing these colonies may play a part in treating eczema. Many current treatments reduce inflammatory bacteria and support the growth of helpful bacteria. There are things you can do to support a healthy and diverse gut microbiome. This may improve skin health, too.

Read more:
Eczema and the Gut-Skin Axis: What's the Link? - Healthline

Eczema is a condition that can make your skin itchy and red. For some, the eczema goes beyond the surface and can be a life long health issue that needs to be managed daily.

Julia Holman and dermatologist Dr. Leslie Storey of the Valley Skin Institute go way back. Julias been her patient for more than half her life about 15 years. Julia has moderate to severe eczema.

My eczema is actually due to my food allergies. So both go hand and hand My eczemas also related to like, stress, so if im stressed, youre gonna see more scratch marks on me, said Julia.

Shes had it since she was a baby.

When I was younger, it was most severe inside my arms and behind my legs. And as I got older, the eczema got worse in different areas, so like on top of my feet and my scalp, Julia stated.

Dr. Storey commented, Eczema is an inflammatory condition of the skin. Its kinda a catch all term, some people will use it for just a rash, some people will use it for something called atopic dermatitis, and its inflammation of the skin from various things that can make it inflamed Anywhere from 15 to 20 percent of the population will have eczema; a lot of kids will have it under the age of five and they actually can outgrow it.

Dr. Storey said every patients experience with eczema varies.

Eczemas a rollercoaster. You do not cure it by any stretch, and you have times where you are super flared and then you have times when youre doing okay and sometimes theres no rhyme or reason, said Dr. Storey.

She said petroleum jelly is best for dry skin, followed by a lotion or cream.

Dr. Storey continued, Your bread and butter, your daily routine with your skin is going to be moisturize, moisturize, moisturize. And you have to find what works in your life, and then you have this kind of middle ground where, are you gonna flare, are you coming off of a flare, so well do a lighter steroid or a non-steroid prescription and when youre flared, well pound it with a steroid.

But for some like Julia, moisturizing her skin is only the beginning.

I just feel like I want to scratch my skin off, and just take my skin off, and so especially on really hot days like today, the first thing Ill do when I go home is take a cold shower. It calms my skin down, and so my skin is wet, so then I hydrate after my shower, said Julia.

Julia has found that a topical steroid plus an injectable medication every two weeks has helped manage her eczema. Shes grateful for healthcare providers like Dr. Storey who go above and beyond to care for their patients.

My favorite thing about Dr. Storey, and Im not kidding when I say, shes my life coach. She would treat me and hear whats working and whats not working, and care for me medically, and then ask how Im doing, and my personal life and academically, ended Julia.

Dr. Story concluded, More than ever we have a lot of treatment options. And so I would say, dont give up by any stretch. With that being said, theres no magic bullet. It takes a lot of work on the patients behalf and the patients family and on their doctor, or their provider that theyre seeing.

Symptoms of eczema include:-dry or itchy skin-red to brownish-gray patches-small raised bumps-thickened, cracked, scaly skin-areas of swelling

Here is the original post:
MedWatch Today: How to Live with Severe Eczema - YourCentralValley.com

They say you dont truly understand something until youve experienced it yourself, and thats certainly been true for me. After spending nearly a decade writing about beauty, I have only recently come to know how challenging it can be to find beauty products that wont irritate sensitive skin.

Earlier this summer, I found myself facing eczema for the first time in my life. I suddenly had raised, rough patches on my cheeks and eyelids, and these never-ending flaky patches around my forehead that my dermatologist recently diagnosed as seborrheic dermatitis. Fun.

I went from using a varied regimen of serums and creams to a very pared down routine thats so bland it blends into my white medicine cabinet. The same goes for my hair products and makeup, which is what were going to dive into now.

In the throes of another flare up, I had the chance to speak with Allan Avendao, who is a celebrity makeup artist to Addison Rae, Vanessa Hudgens and Sarah Hyland among others. Though Ive long admired his work on Instagram, I was especially excited to talk to Allan because he is also intimately familiar with the difficulties of navigating the beauty aisles with a skin condition; hes had plaque psoriasis, which is a chronic autoimmune disease that appears on the surface of the skin as raised, red, itchy patches, since he was a kid.

Here are some of the key takeaways I learned from our convo.

One of the top offenders when it comes to causing irritation is fragrance. (A few other culprits to watch for are parabens, formaldehydes and alcohol.) Fragrance is found in many, if not most, beauty products, so youll need to look carefully at the ingredient lists to make sure its not hiding there.

On the flip side, some ingredients you want in your products are hyaluronic acid, glycerin and ceramides. These hydrating ingredients help draw in moisture and lock it in, which is crucial because dehydrated skin is more prone to inflammation.

So, before you proceed with any makeup, always make sure to gently cleanse (never scrub) your face and follow up with a layer of moisturizer to prep your skin.

Finally, when youre dealing with sensitive skin or skin conditions like eczema or psoriasis, its always good practice to patch test any new products before you commit to a full face.

Whether its a new foundation or a blush, apply a small amount of it to the inside of your wrist and see if your skin reacts to the formula. If it causes any sort of irritation to your wrist, its likely going to do the same to your face. If theres no reaction, you can proceed.

OK, so this isnt technically makeup, but sunscreen is a must, and this derm-approved formula also has enough tint in it to even out the reddest tones on your skin. Plus, its very moisturizing and leaves a subtle glow behind. Most importantly, it doesnt trigger a reaction thanks to its fragrance-free and zinc oxide-based formula. (Note: Physical sunscreens tend to work better for those of us with sensitive skin.)

Buy it ($39)

On days where I want just a little more coveragebe it under my eyes or over any splotchesIll tap a small amount of this creamy stick wherever its needed. The formula is easy to blend and quickly blurs out any areas of discoloration to create a more even-looking finish. Currently its available in 20 shades and is formulated to EU standards, which are among the strictest, and eliminates any ingredients that might trigger inflammation such as artificial fragrance.

Buy it ($38)

With a tagline that states: Designed for sensitive skin, made for all, I had high hopes that this would be safe for me to use. Thankfully, it passed the patch test and Ive been able to enjoy this buttery blush without any issues. The six shades can be sheered out or built up to your desired level of color and the results are always natural looking.

Buy it ($20)

This highlighter has won many awards (and picked up many celebrity fans) over the years thanks to the soft, never sparkly glow it leaves on your skin. With a streamlined ingredient list thats mostly made up of castor seed and coconut oil, you can put it on your skin without having to worry about aggravating it.

Buy it ($38)

Eyelid eczema makes it difficult to wear most eyeshadows, which is why I was ecstatic when this palette passed my patch test. As it turns out, many of Tartes products are mineral-based, which is often recommended for people with sensitive skin. Each of the 12 shades in the palette are also infused with Amazonian clay to give them a creamier consistency and better color payoff. From a warm taupe to a chestnut brown (and multiple shades of bronze, tan and peach in-between), you can easily create different looks to fit any occasion.

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And for the finishing touch, Ive been wearing this buttery lip gloss from Minori. There are four, universally flattering shades to choose from, but I find myself wearing Juneberry the most, which is a cool pink with a subtle shimmer. The gloss itself is velvety and hydrating on your lips and leaves nary a flake behind.

Buy it ($22)

RELATED: The 25 Best Lip Glosses to Keep Your Lips Plump, But Not Sticky

Read the original:
The Best Makeup for Sensitive Skin, According to a Beauty Editor with Eczema - PureWow

Pfizer (NYSE:PFE) recently reported positive results for its experimental drug abrocitinib in a late-stage study targeting eczema, an inflammatory skin disease also known as atopic dermatitis. The study featured a head-to-head comparison between Pfizer's drug and Dupixent, which is marketed by Sanofi (NASDAQ:SNY) and Regeneron (NASDAQ:REGN).

Could Pfizer beat Sanofi and Regeneron in the eczema market? That's the topic of discussion inthis Motley Fool Live video recorded on Sept. 1, 2021, with Motley Fool contributors Keith Speights and Brian Orelli.

Keith Speights: Let's turn to some non-COVID news for some big players in the COVID-19 market. Pfizer recently reported its top-line results from a phase 3 study of abrocitinib. This study was a head-to-head comparison between abrocitinib and Sanofi'sand Regeneron'sDupixent in treating eczema (or atopic dermatitis).

Brian, what do you think about Pfizer's news here? Does the company have a chance of even beating Sanofi and Regeneron in the eczema market?

Brian Orelli: This was a top-line result, all we know is that the trial was successful, we don't actually have any data.

The study measured the percent of patients who had a four-point improvement on a scale that measures itching. Then they also measured the percent of patients who had a 90 percent clearance of their eczema.

Abrocitinib beat Dupixent on both of those endpoints. We just don't know by how much and obviously, the delta there and how many more people were helped. This obviously is going to be very important, but Pfizer's saving that data for a medical meeting or for a publication. Well, efficacy is certainly important, so is safety.

Abrocitinib is in the JAK class, which is has been marred with safety issues since the post-marketing study of Pfizer's Xeljanz showed that the drug had a higher rate of cardiovascular issues and also higher rates of cancer. There were two deaths in this study that was just published.

One was COVID-19 related, so probably not that big of a deal. But the other one was an intracranial hemorrhage and cardiorespiratory arrest. That's clearly cardiovascular. The investigators characterize it as unrelated to the drug. But I think it's just going to add fuel to this fire with the safety issues with JAK inhibitors.

Ever since, abrocitinib is under FDA review for eczema. The FDA has put off a decision on the drug. The PDUFA date has already passed. The goal that the FDA sets for itself to make a decision and it let that PDUFA date pass, because it's still reviewing the Xeljanz data. So it's going to make it a decision on the Xeljanz data and then make a decision on abrocitinib and a few other JAK inhibitors that also are under review that should have already had a decision for. We'll have to wait and see what warning abrocitinib gets before we can really know how well it can compete against Dupixent.

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WEDNESDAY, Sept. 8, 2021 (HealthDay News) -- Eczema doesn't just irritate kids' skin. The often disfiguring condition may also be tied to depression, anxiety and sleep difficulties, new research warns.

A study of more than 11,000 British children and teens found that those with severe eczema were twice as likely to become clinically depressed as eczema-free kids.

"Eczema is an itchy red skin disease," said study author Dr. Katrina Abuabara, an associate professor of dermatology at the University of California, San Francisco.

But it's complex.

"The disease course and severity can be quite variable," explained Abuabara. "It often presents in early childhood, but can occur at any age. It tends to be episodic, flaring up, then remitting, but these cycles can be chronic over years.

"For many children, the disease seems to improve by their teen years, but we've found that some continue to have episodic disease into adulthood," she added.

Risk goes up among those with a family history of the disease or related conditions like asthma and allergies. And the condition "is quite common, affecting up to 20% of kids and 10% of adults," Abuabara noted.

Among the children she and her colleagues started tracking in 1991, the annual prevalence of eczema -- also known as atopic dermatitis -- ranged from 14% to 19% between the ages of 3 and 18.

Roughly 22% to 40% developed a moderate or severe form of the disease; the rest of the cases were mild.

In addition to being linked to a doubling of depression risk, severe eczema also doubled the risk for the kind of depressive and/or anxiety-linked behaviors that typically indicate underlying emotional and psychological difficulties. Severe cases also drove up the odds for sleep troubles.

The depressed children were more likely to be female, and from a higher social class, the authors found.

Mild and moderate eczema were not linked to a higher risk for childhood depression, the team stressed. But among children as young as 4, even less serious cases of eczema were associated with a 29% to 84% spike in the risk for internalizing behaviors.

That's concerning, Abuabara and her colleagues noted, because children who struggle with depression and/or brewing emotional turmoil may face a higher risk for depression, anxiety and poor overall health as adults.

"Many parents of children with eczema will tell you it can be a deceptively devastating disease," Abuabara said.

"Eczema has long been known to cause sleep disturbances which impact the whole family," she added, "and certainly can take a toll on emotional well-being. Increasingly, studies are revealing that some types of eczema are more than 'skin deep', and can impact overall health in a variety of ways."

In general, "skin disease is well known to affect patients' quality of life and cause depression," agreed Dr. Robert Kirsner, chairman of the department of dermatology and cutaneous surgery at the University of Miami Miller School of Medicine.

Children are often thought to be relatively resilient in that respect, said Kirsner, who was not part of the study team.

But "understandably, severe eczema, even in children, can cause depression and associated internalizing symptoms such as low self-esteem, fear and worrying," he said.

Of note is the finding that even "less severely affected patients apparently are emotionally affected by disease, and may internalize their feelings and manifest symptoms," Kirsner said.

This suggests "more aggressive, expert treatment for even mild eczema might improve the lives of children, and has potential for longer term mental health benefits," he added.

What can parents do?

Abuabara said they should strive to get the best care possible, not only for eczema itself but for the emotional hardship it may trigger.

"If you have a child with eczema that you're concerned about, it is important to talk to their doctor about optimizing their eczema treatment and to ask about behavioral screening and support through their clinic and/or school," Abuabara said.

The findings appear in the Sept. 1 online edition of JAMA Dermatology.

More information

There's more on eczema at the National Eczema Association.

SOURCES: Katrina Abuabara, MD, MSCE, associate professor, dermatology, University of California, San Francisco, and associate adjunct professor of epidemiology, University of California, Berkeley School of Public Health; Robert Kirsner, MD, PhD, chairman and professor, department of dermatology and cutaneous surgery, University of Miami Miller School of Medicine, and director, University of Miami Hospital and Clinics Wound Center; JAMA Dermatology, Sept. 1, 2021, online

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Eczema Can Take Toll on Child's Mental Health - HealthDay News

Over 70 percent of the immune system is located within the gut, so eliminating any possible food allergies from the diet could help to reduce the high levels of circulating IgE.

The most common food allergies in patients with eczema are milk, egg, and peanuts, according to Claire.

She said: Eliminating these allergens from the diet for at least two weeks, before slowly reintroducing them one by one should provide clues to which ones, if any, are causing symptoms or flare-ups.

If eliminating any food groups from the diet, especially with infants and young children, I would strongly recommend seeking the advice of a local registered Nutritional Therapist as you do this, to reduce the likelihood of nutritional deficiencies.

If the infant is still being breastfed, the mother may wish to try an elimination diet whilst looking for corresponding symptoms in the infants skin condition.

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