Category Archives: Eczema

Researchers from the La Jolla Institute for Allergy and Immunology in California have discovered a key player in the cellular interactions leading to eczema, a chronic inflammatory skin condition affecting more than 14 million Americans. The skin of sufferers becomes inflamed or irritated and is marked by redness, itchiness, and dry, cracked skin.

In a study published January 10th 2014 in the journal Cell Reports, Toshiaki Kawakami, M.D., Ph.D. and colleagues provide information that supports for the first time in humans the long-held theory that mast cells are a key culprit in causing eczema, also known as atopic dermatitis. These cells, sometimes called mastocytes and labrocytes, are known to foster allergies although on the plus side, they also help with wound healing and defend against pathogens.

According to a release from the institute, the team also showed that a cellular protein known as STAT5 plays a pivotal role in the development of eczema by triggering major increases in mast cells in the skin of some eczema sufferers. The discovery opens the door to creating new therapies to prevent or better treat eczema based on blocking STAT5 in mast cells.

The release quotes Kawakami as saying, "We found that the number of mast cells, which we have previously shown to be important in mouse atopic dermatitis, is increased in human patients. We also showed that these mast cells contain high levels of the active form of STAT5."

Kawakami says this finding is a continuation of his nearly 10-year effort to pinpoint the cascade of key cellular actions involved in eczema. His latest study enabled human confirmation of his earlier findings in mouse models. "We now know that, in eczema, the mechanisms we found in mice are also operative in human disease," he said.

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Cause of Eczema Discovered

Dr Jeevani Hasantha Testimonials-eczema
Eczema patient describes how homeopathy cured him compleately with a very short period at Sajeevi Healing Home.

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Dr Jeevani Hasantha Testimonials-eczema - Video

PUBLIC RELEASE DATE:

9-Jan-2014

Contact: Linda Huynh linda.huynh@nih.gov 301-402-1663 NIH/National Institute of Allergy and Infectious Diseases

A study reports the development of a new mouse model for atopic dermatitis, an inflammatory skin disorder commonly known as eczema. The findings, published in Cell Reports, suggest that mast cells, a type of immune cell, are critical for both spontaneous and allergen-induced eczema. The study, led by researchers at the La Jolla Institute for Allergy and Immunology, was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health.

Eczema is estimated to affect approximately one in five infants and one in fifty adults in the United States. The causes underlying the disorder are unclear. Previous research has suggested a role for imbalanced immune responses and impaired skin defenses, as well as overproduction of thymic stromal lymphopoietin (TSLP), a protein that promotes inflammation. While different mouse models for eczema have been developed, research examining how they are linked to human disease is still ongoing.

In the current study, researchers show that mice lacking phospholipase C-3 (PLC- 3), an enzyme that helps regulate inflammation, develop a skin disorder similar to human eczema, with high levels of TSLP. In this model, disease progression depends on the accumulation of mast cells and the activity of a signaling protein called Stat5. This role for mast cells and Stat5 in eczema was not previously known. The researchers also examined skin lesions of eczema patients and found that some had accumulation of mast cells expressing active Stat5. They identified changes, or polymorphisms, in genes that regulate PLC- 3 and Stat5 that are more common in patients with eczema. With these links to human disease, the targets identified in the mouse model may offer potential new strategies for treating this common disorder in people.

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ARTICLE: T. Ando et al. Critical role for mast-cell Stat5 activity in skin inflammation. Cell Reports. DOI: 10.1016/j.celrep.2013.12.029 (2014).

Marshall Plaut, M.D., chief of the Food Allergy, Atopic Dermatitis and Allergic Mechanisms Section in NIAID's Division of Allergy, Immunology and Transplantation, is available to discuss the findings.

To schedule interviews, please contact Linda Huynh, (301) 402-1663, linda.huynh@nih.gov.

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NIH-funded scientists develop mouse model for atopic dermatitis

PUBLIC RELEASE DATE:

9-Jan-2014

Contact: Bonnie Ward contact@liai.org 619-303-3160 La Jolla Institute for Allergy and Immunology

SAN DIEGO (January 9th, 2014) Researchers from the La Jolla Institute for Allergy and Immunology have revealed a critical player in the cellular interactions leading to eczema a chronic inflammatory skin condition affecting more than 14 million U.S. children and adults.

In a study published today, Toshiaki Kawakami, M.D., Ph.D., and his research team provide information which supports for the first time in humans the long-held theory that mast cells are a key culprit in causing eczema, also known as atopic dermatitis. Further, the team showed that a cellular protein, known as STAT5, plays a pivotal role by triggering major increases in mast cells in the skin of some eczema sufferers. The discovery opens the door to creating new therapies to prevent or better treat eczema based on blocking STAT5 in mast cells.

The team conducted its studies using skin samples from eczema patients. "We found that the number of mast cells, which we have previously shown to be important in mouse atopic dermatitis, is increased in human patients," says Kawakami. "We also showed that these mast cells contain high levels of the active form of STAT5."

Kawakami says the researchers also tested their theory on STAT5's importance in mice. "When STAT5 is knocked out in the mast cells (of specially engineered mice), the mice become resistant to atopic dermatitis," says Kawakami. "This indicates that STAT5 regulatory mechanisms in mast cells are important for the pathogenesis of this disease."

The findings were published online in Cell Reports in a paper entitled "Critical role for mast-cell Stat5 activity in skin inflammation." The study was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, under contract number N01 AI40030.

Eczema is a condition in which the skin becomes inflamed or irritated and is marked by redness, itchiness and dry, cracked skin. The exact cause of eczema is unknown, but it's thought to be linked to an overactive response by the body's immune system to allergens and irritants, similar to other allergic diseases such as asthma and food allergy. Eczema is more common in children than adults, since it sometimes resolves with age. About 10.7 percent of U.S. children and 3 percent of adults are estimated to be affected.

Kawakami says this finding is a continuation of his nearly 10-year effort to pinpoint the cascade of key cellular actions involved in eczema. Initially working in mice, his latest study enabled human confirmation of his key findings. "We now know that, in eczema, the mechanisms we found in mice are also operative in human disease," says Kawakami. Along with showing that mast cells and STAT5 drive the eczema process in humans, this study also found an enzyme -- Phospholipase C-beta3 (PLC-3) that can block the activation. PLC-3 has a calming effort on STAT5 and can prevent it from driving up the mast cell numbers, explains Kawakami. "The mast cell numbers are inversely correlated with PLC-3 levels," he says. "The more PLC-3, the fewer the mast cells."

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La Jolla Institute scientist identifies pivotal cellular protein underlying eczema

Eczema cracked lips makeup
Hello everyone, This tutorial gives few little tricks how to make your cracked lips look little better when you absolutely need to go out and look presentabl...

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Eczema cracked lips makeup - Video

WARNING: No information on this website is intended to diagnose, treat, cure or prevent any disease. This home remedies site is intended to be archival in nature. The natural remedies here are submitted by numerous people from around the world, and it is impossible to verify every remedy. As such these home remedies should be used for academic purposes only. Never use any home remedy or other self treatment without being advised to do so by a physician. 239 home remedy submissions for Eczema Submitted by Leslie at 2013-12-04 18:04:03 I had a very bad flair up of eczema on my hands. I have used prescription cortico-steroids in the past. They are prohibitably expensive. I have discovered a cream called Bye Bye Dry, by BabyGanics, in the baby section at Walgreens. Less than a week after I began using the cream the cracks are gone and are not bleeding anymore. Give it a try. Submitted by Katie at 2013-11-05 08:24:04 In recent months I have had a bad case of eczema around my eyes, mouth and all over my hands and arms, I have tried many products and natural remedies and I thought I'd share the ones that worked for me.

Facial eczema:-

Eyes - many websites that I have searched through recommended the Elizabeth Arden 8 hour cream, but for such a small amount it was costing over 25 in Boots. As an alternative I went to Holland and Barratt, they have a brand called Burt's Bees, I got a 50g pot of their sensitive night cream (another 8 hour cream) for around 14 and within 2-3 days my eyes were almost healed. I used the cream as often as necessary and after a week my eyes were no longer red and blotchy, just a little dry, which cleared up with the continued use of this cream.

Mouth - around my mouth I used the Burt's Bees cream, also a very small amount of Fucidin hydrocortisone cream on my lips and at the corners. This was the first area to heal.

Hands and arms - my hands have been a long term eczema sore spot, especially my palms which crack and bleed. The creams that were prescribed to me were; Cetraben emollient cream (used as much as needed, general moisturiser, especially good to use in cotton gloves at night), Fucidin hydrocortisone cream. However, the cream that has healed my hands completely is Mometasone Furoate Cream (0.1% w/w). Improvement to my hands was apparent overnight! If you cannot get these creams on prescription, other things that I have tried include, Aveeno daily moisturising lotion around 5 in Boots, Badedas shower and bath gels, my eczema is aggravated by water, I found I could soak in the bath for as long as possible using Badedas. Also porridge oats work when used in the bath (cut off the foot of a pair of tights and fill with porridge oats then tie it up, either attach to the tap or just dropped in the bath while it fills, the porridge oat moisture really soothe the skin). I really hope these ideas work for you as well as they have done for me!

Someone else please please please try and vote my reply if it works for you. I work for neither Boots nor Bio-Oil, just want to share to help someone else.

It truly has been a miracle for our son. Because he takes such a small dose, it it not too expensive. $5-10 a month, since one bottle lasts 4-8 months. I do not sell this product but I can tell you where to get it. 🙂

We have also had success with Body By Vi Shake Mix. Froggzzz@gmail.com

-While things that make you sweat like sports may do well to be avoided remember that exercise helps reduce stress, and I know a lot of us find our conditions are aggravated by stress. This is the most stressful my life has ever been and my eczema is awful. I don't like to, but I've resorted to prednisone just to get some relief. I ride my bike everywhere though and while the sweating doesn't help the workout does. Exercise reduces stress which reduces eczema.

-Activated quercetin has been extremely helpful in managing my allergies, asthma and eczema during lower-allergy-activity seasons. During spring and summer I often have to be on benadryl and sudafed and inhalers and prednisone. But the rest of the year I rely on activated quercetin. It's extremely effective in supporting histamine response and immune response. And it's not a drug (find it in natural stores in the supplements section).

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Home Remedies for Eczema - My Home Remedies - Home Remedy Forum

(WTVM) -

With the low temperatures we've seen over the last few days, many organizations around the Chattahoochee Valley have lent a helping hand to people in need of a warm place to stay.

Five shelters opened their doors, some to anyone in need. A warming station was also set up at one shelter allowing the homeless a place to come in and warm up from the bitter cold.

At least 20 other deaths around the country are being blamed on the frigid weather.

Since the weather has returned to normal, the warming station at the SafeHouse closed at 5 p.m. Wednesday evening. The following shelters in the city have resumed their normal operations:

Valley Rescue Mission - Shelter for Men 2093 2nd Ave., Columbus, Ga. (706)322-8267 On Wednesday evening, Valley Rescue will have 6-10 additional beds of emergency shelter for men.

Salvation Army - Shelter for Men 1718 2nd Ave., Columbus, Ga. (706)327-0275 The Salvation Army will provide additional bed space on Wednesday. A limited number of blankets and sleeping bags have been available for distribution.

House of Mercy - Shelter for men, women and children 1532 3rd Ave., Columbus, Ga. (706)322-6463 House of Mercy will open their chapel for men, women and children to provide for additional emergency shelter on Wednesday evening.

Trinity House - Shelter for Women and children On Wednesday evening, Trinity will provide additional bed space for homeless women and children. Please call (706)641-8485 for information and assistance.

Damascus Way - Shelter for women and children. 1200 11th Ave., Columbus, Ga. (706)653-2061, ext. 3.

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Come in from the cold: Shelters open additional spaces for homeless on Tues. Jan. 7

Calcutta News.Net - Wednesday 8th January, 2014

Violence against women, wife battery, honour killings and even foeticide among the Indian diaspora in Canada are a cause of worry, say Indo-Canadian delegates at a diaspora meet here. They added that they strive to help the Indian immigrants get assimilated into the mainstream. Molly Banerjei, a businesswoman from Toronto, told IANS: "Domestic violence is rampant among the Indian ...

Calcutta News.Net - Wednesday 8th January, 2014

Despite perceptions in some quarters outside that India is losing its momentum of growth achieved in the past decade, there is no need to worry, Prime Minister Manmohan Singh said Wednesday. "There is a perception in some quarters outside India that the country is losing its momentum of the past decade," he said while addressing the inaugural ceremony of the 12th Pravasi Bhartiya Divas, the ...

Calcutta News.Net - Wednesday 8th January, 2014

Computer science undergraduates have developed image based mobile phone alerts, connected to the Weather Research and Forecasting system, which could help prevent casualties in India. India has a mobile phone subscriber base exceeding 929 million people and this is expected to touch 1.15 billion by the end of 2014. An alert system developed for mobiles could reach an estimated 97 per cent of ...

Calcutta News.Net - Wednesday 8th January, 2014

A sugar-sweetened beverage (SSB) tax can help reduce the rise in obesity and type 2 diabetes rates in India, a new study has suggested. Sanjay Basu and colleagues, from Stanford University, USA, estimated that a 20 per cent SSB tax across India could avert 11.2 million cases of overweight/obesity and 400,000 cases of type 2 diabetes between 2014 and 2023, based on the current rate of increases ...

Calcutta News.Net - Tuesday 7th January, 2014

Many Muslims in Delhi are very happy with the arrival of Arvind Kejriwal and his Aam Aadmi Party (AAP) on the political scene. But Muslims, who always had a representation in the Sheila Dikshit cabinet, are disappointed that there is no Muslim in Kejriwal's cabinet. Muslims themselves are to be blamed for this. Prior to and during the Delhi elections, Kejriwal left no stone unturned to court ...

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(WTVM) -

Many health problems are commonly associated with cold weather, such as coughs and the flu, and even hypothermia. But one physical issue that often gets overlooked this time of year is eczema and other itchy, burning skin conditions caused by the dryness in the winter air.

Dr. Ella Amador from MyCare Urgent Care in Columbus stopped by the WTVM studio and offered several tips for avoiding nose bleeds, eczema and extremely dry skin this winter.

1. Avoid turning the thermostat up too high. When the temperature drops outside, it's natural to want to raise it extra high inside. "We want to raise it to a comfortable 74 to 78 degrees," says Amador. However, the added heat can make the air even dryer, creating worse issues for your skin.

2. Run a humidifier in the room. "The cold weather doesn't permit for good moisture retention in your skin," says Amador. "Kids will have nose bleeds. Your skin would also be dry. So, I generally recommend keeping a humidifier in the room, just in case."

3. Keep showers short and not too hot. Another easy way to get warm is to take a long, hot shower. The heat feels great, but Amador says, "It strips away the natural oils in your skin."

4. Avoid using harsh soaps. Amador says soaps that are heavily scented can be particularly harsh on the skin. A good, mild soap is best for dry, wintry weather.

5. Pat dry instead of rubbing your skin. This can also help retain the skin's natural oils.

6. Find a good moisturizer. Never underestimate the power of a good lotion or body cream. Amador advises using an unscented lotion liberally after taking a shower or bath.

The winter months do not have to be itchy season. While some of these tips may mean avoiding the usual quick fixes for getting warm, they could also mean that you're able to be more comfortable in your own skin.

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6 ways to avoid dry skin problems this winter

PUBLIC RELEASE DATE:

7-Jan-2014

Contact: Maria Jenmalm, Professor maria.jenmalm@liu.se 46-702-378-970 Linkping University

Low gut microbial diversity in the intestines of infants can increase the risk for asthma development. These are the findings of the age 7 follow-up in a multi-year study led by researchers at Linkping University.

In 2011 the results of a comprehensive survey of the intestinal microbiota of allergic and healthy children were published. In the samples from the infancy period, the degree of variation and diversity of the bacteria strains was significantly lower among those who had developed allergic eczema when they were two years old.

A follow-up study was conducted when the 47 participating infants reached their seventh birthday. By then eight of them 17% were suffering from chronic asthma. 28% had hay fever, 26% still had eczema, and 34% reacted to the allergens in a skin prick test. But it was only the asthma cases that could be connected to low intestinal microbial diversity at the age of one week and one month, according to the results now being published in the scientific journal Clinical & Experimental Allergy.

It might seem a bit of a stretch to think the contents of the intestines could influence what happens in the airways. The results of this study, however, give further credence to this connection, which has previously been demonstrated in animal studies.

"A high diversity of gut microbiota during the first months of life seems to be important for the maturation of the immune system," says Thomas Abrahamsson, paediatrician and researcher at Linkping University, and principal author of the article. The hypothesis is that in order to function effectively, the immune system needs to be "trained" by large numbers of different microorganisms. In the absence of sufficient stimulation from large numbers of different bacteria, the system may overreact to innocuous antigens it encounters.

A high gut microbial diversity has also been shown to strengthen the barrier function of the mucous membrane.

"We are speculating that a deficient maturity of the immune system at an earlier age and a less efficient mucosa barrier function can open the way to certain types of viral infection that can be linked to the development of asthma," says senior author Maria Jenmalm, professor of experimental allergology.

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Low diversity of bacteria may increase the risk for asthma