Category Archives: Eczema

PUBLIC RELEASE DATE:

5-May-2014

Contact: Jack Stonebridge pr@kcl.ac.uk 020-784-83202 King's College London

Eczema caused by defects in the skin could reduce the risk of developing skin cancer, according to new research by King's College London. The immune response triggered by eczema could help prevent tumour formation by shedding potentially cancerous cells from the skin.

There is ongoing debate surrounding allergic diseases and their impact on the likelihood of developing cancer, with some studies suggesting that eczema is associated with a reduced risk of skin cancer. However, it is difficult to draw firm conclusions based on studies of human populations because eczema symptoms vary in severity and drugs used to treat the condition might also influence cancer. Published today in eLife, the study by researchers at King's College London is the first to show that allergy caused by the skin defects could actually protect against skin cancer.

Skin cancer is a common and growing problem, accounting for one in every three cancers diagnosed worldwide, according to the World Health Organization. Recent findings suggest that malignant melanoma, the most dangerous form of skin cancer, is now five times more common in the UK than it was in the 1970s.

Eczema can result from the loss of structural proteins in the outermost layers of the skin, leading to a defective skin barrier. Genetically engineered mice lacking three skin barrier proteins ('knock-out' mice) were used in the King's study to replicate some of the skin defects found in eczema sufferers.

The researchers, funded by the Medical Research Council (MRC), the Wellcome Trust and Cancer Research UK, compared the effects of two cancer-causing chemicals in normal mice and mice with the barrier defect (the knock-out mice). The number of benign tumours per mouse was six times lower in knock-out mice than in normal mice. The findings suggest that defects in the epidermal barrier protected the genetically engineered mice against benign tumour formation.

Researchers found that both types of mice were equally susceptible to acquiring cancer-causing mutations. However, an exaggerated inflammatory reaction in knock-out mice led to enhanced shedding of potentially cancerous cells from the skin. This cancer-protective mechanism bears similarities to that which protects skin from environmental assaults such as bacteria.

Professor Fiona Watt, Director of the Centre for Stem Cells and Regenerative Medicine, said: 'We are excited by our findings as they establish a clear link between cancer susceptibility and an allergic skin condition in our experimental model. They also support the view that modifying the body's immune system is an important strategy in treating cancer.

Original post:
Having eczema may reduce your risk of skin cancer

ECZEMA sufferers may have less chance of developing skin cancer, research published today suggests.

The study, published in eLife, is the first to show that eczema symptoms could actually protect against skin cancer, experts at Kings College London said. Previous studies have suggested a link but it has been tough to stand up.

The researchers found the immune response triggered by the skin condition could stop tumours forming by shedding potentially cancerous cells.

Genetically engineered mice lacking three skin proteins knockout mice were used to replicate skin defects found in eczema sufferers.

The scientists studied the effects of two cancer-causing chemicals and found the number of benign tumours per mouse was six times lower in knockout mice than normal ones.

Both types of mice were equally prone to cancer-causing mutations, Kings College said, but an exaggerated inflammatory reaction in knockout mice led to more shedding of potentially cancerous cells from the skin.

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